DEGUCHI Yoshiharu 出口芳春

… Alternative Names

DEGUCHI Yoshlharu 出口芳春

Less

Researcher Number	40254255
Other IDs
External Links
Affiliation (Current)	2025: 帝京大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2010 – 2025: 帝京大学, 薬学部, 教授 2007 – 2008: Teikyo University, 薬学部, 教授 2005: Teikyo University, School of Pharmaceutical Sciences, Professor, 薬学部, 教授 2002 – 2004: 帝京大学, 薬学部, 助教授 2000: Hokkaido College of Pharmacy, Department of Biopharmaceutics, Assistant Professor, 薬学部, 講師 1995 – 1999: 静岡県立大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Medical pharmacy / 応用薬理学・医療系薬学 / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator 血液脳関門 / トランスポーター / ヒトiPS細胞 / blood-brain barrier / 血液脳関門モデル細胞 / 脳移行性 / 不死化細胞株 / ヒト不死化脳毛細血管内皮細胞 / ヒトiPS細胞由来脳毛細血管内皮細胞 / bFGF … More / エンドサイトーシス / ヘパラン硫酸プロテオグリカン / FGFレセプター / 塩基性線維芽細胞成長因子 / probenecid / プロベネシド / 排出輸送 / モノカルボン酸輸送系 / 脳灌流法 / ヒト血液脳関門モデル細胞 / ヒト脳移行性 / 有機カチオン性薬物 / 有機カチオントランスポーター / ヒトiPS細胞由来脳関門細胞 / ３次元チップ / マイクロフィジオロジカルシステム / 血液脳脊髄液関門モデル細胞 / ヒト不死化脳脊髄液関門細胞 / ヒト脳脊髄液関門細胞 / ヒトiPS細胞由来脳毛細血管内皮細胞様細胞 / ３次元培養チップ / 薬物輸送機能 / 定量的PCR / 方向性輸送 / トランスウェル2次元培養 / 高分子デリバリー / P-糖たんぱく質 / トランスウェル / ドラッグデリバリーシステム / 高分子輸送 / 不死化脳毛細血管内皮細胞 / 輸送性レセプター / 有機カチオン-プロトン交換輸送系 / 塩基性薬物 / 基質認識性 / プロトン-有機カチオン交換輸送系 / ヒトiPS由来脳毛細血管内皮細胞 / ヒト脳毛細血管モデル / 薬物認識性 / 有機カチオン輸送系 / neuroprotection / stroke / FGFRs-expressing cells / FGF receptor / delayed neuronal death / ammonal model for ischemia / 脳保護機 / 脳保護機構 / 脳卒中 / FGFRs恒常発現株 / 遅発性細胞死 / 虚血動物 / endocytosis / basic fibroblast growth factor / opioid peptides / peptide transport system / immortalized cells / heparan sulfate proteoglycan / adsorptive-mediated transport / パーレカン / 免疫染色 / ペプチド / 塩基性繊維芽細胞成長因子 / カチオン性ペプチド / 吸着介在型輸送 / オピオイドペプチド / ペプチド輸送系 / 吸着介在性輸送 / Transport for Large Molecule / FGF Receptor / Heparan Sulfate Proteoglycan / Immortalized Culture Cells / Endocytosis / Basic Fibroblast Growth Factor / Drug Efflux Transport / Blood-Brain Barrier / トランスサイトーシス / ヘパリン / 血管脳関門排出輸送 / 血管脳関門 / 高分子輸送能 / 薬物排出輸送 / prodrug / improvement of CNS delivery / 6-mercaptopurine / ketoprofen / Alzheimer's disease / BBB efflux transport / anion transport system / グリセロール / 脳内代謝 / 脳送達法 / アセチルコリンエステラーゼ阻害薬 / ペプチド性薬物 / 脳移行性改善 / 6-メルカプトプリン / プロドラッグ / 脳移行性改善法 / ケトプロフェン / 血液脳関門排出輸送 / アルツハイマー病 / アニオン輸送系 / salicylate / organic anion drugs / monocarboxylic acid transporter / microdialysis / efflux transport / brain perfusion / 脳細胞間液 / 脳内薬物動態 / 排出過程 / マイクロダイアリシス / 酸性薬物 / サリチル酸 / フロー培養システム / 循環培養システム / 発現解析 / 輸送特性 / 遺伝子抑制 / RNAiライブラリー / ヒト由来不死化細胞株 / スケールアップ / 遺伝子解析 / カチオン性薬物 / ヒト細胞株 / OCTN2 / siRNA / TR-BBB13 / PMAT / モノアミン / 有機カチオン性物質 / PAMT / ピリラミン / 薬物動態学 … More Except Principal Investigator トランスポーター / 血液脳関門 / 薬物相互作用の予測 / 内因性バイオマーカー / 生理学的薬物速度論（PBPK）モデル / 薬物相互作用 / 内在性バイオマーカー / 生理学的薬物速度論モデル（PBPK） / 薬物間相互作用 / BBB in vitroモデル / Exosome / transfer DDS / 抗体医薬 / 脳 / 脳微小透析法 / オキシコドン / オピオイド受容体 / オピオイド鎮痛薬 / オピオイド / transporter / opioid / siRNA / OCTN2 / carnitne / organic cation / blood-brain barrier / 交換輸送体 / カチオン / 鎮痛薬 / 有機カチオン Less

医薬工の技術連携による脳関門統合マイクロ生体模倣システムの開発Principal Investigator
- Principal Investigator
  
  出口芳春
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Teikyo University
脳内神経細胞への抗体医薬送達を実現するtransfer DDSの創出
- Principal Investigator
  
  安楽泰孝
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Institute of Science Tokyo
Integrated development of quantitative prediction methods for complex drug-drug interactions involving transporters
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Josai International University
Creation and clinical application of 3D brain barrier chips using human iPS cellsPrincipal Investigator
- Principal Investigator
  
  出口芳春
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Teikyo University
Functional elucidation of human blood-brain barrier using iPS-derived brain microvascular entdothelial cellsPrincipal Investigator
- Principal Investigator
  
  Deguchi Yoshiharu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Teikyo University
Elucidation of the drug recognition properties and molecular entities of the organic cation-proton exchange system at the human blood-brain barrierPrincipal Investigator
- Principal Investigator
  
  Deguchi Yoshiharu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Transport aross the blood-brain barrier in relation to CNS actions of opioid analgesics
- Principal Investigator
  
  Okura Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Development of a novel experimental evaluation method for predicting the drug delivery to the brain in humanPrincipal Investigator
- Principal Investigator
  
  DEGUCHI YOSHIHARU
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
The Blood-Brain Barrier Transport Mechanism Controlling Analgesic Effects of Opioid Drugs in the Central Nervous System
- Principal Investigator
  
  OKURA Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Prediction of the human brain distribution for the central nervous system drugs using a novel human immortalized brain capillary endothelial cellsPrincipal Investigator
- Principal Investigator
  
  DEGUCHI Yoshiharu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Identification and Functional Characterization of Pyrilamine Transporter, an Organic Cation TransporterPrincipal Investigator
- Principal Investigator
  
  DEGUCHI Yoshlharu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Functional Changes in the Blood-Brain Barrier and Neuroprotective Effects in the Brain IschemiaPrincipal Investigator
- Principal Investigator
  
  DEGUCHI Yoshiharu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Functional and Molecular Analysis of Peptide/Protein Transport System in the Blood-Brain BarrierPrincipal Investigator
- Principal Investigator
  
  DEGUCHI Yoshiharu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Teikyo University
Control of the drug efflux transport from the brain utilizing the transport function for the large molecules〜Principal Investigator
- Principal Investigator
  
  DEGUCHI Yoshiharu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Hokkaido College of Pharmacy
  University of Shizuoka
Development of Novel CNS Drug Delivery System by Regulating the BBB Efflux Transport SystemPrincipal Investigator
- Principal Investigator
  
  DEGUCHI Yoshiharu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  University of Shizuoka
Quantitative Evaluation of Blood-Brain Barrier Efflux Transport of DrugsPrincipal Investigator
- Principal Investigator
  
  DEGUCHI Yoshiharu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  University of Shizuoka

[Book] コンパス生物薬剤学（改訂第３版）2021
- Author(s)
  出口芳春, et al.
- Total Pages
  285
- Publisher
  南江堂
- ISBN
  9784524403745
- Data Source
  KAKENHI-PROJECT-19K07231
[Book] コンパス生物薬剤学2016
- Author(s)
  出口芳春
- Total Pages
  7
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-25460199
[Book] 薬の生体内運命（改訂第６版）2015
- Author(s)
  出口芳春
- Total Pages
  22
- Publisher
  ネオメディカル
- Data Source
  KAKENHI-PROJECT-25460199
[Book] 薬物分布実験法　脳関門2014
- Author(s)
  黄倉崇、出口芳春
- Total Pages
  13
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-25460199
[Book] 細胞工学　トロイの木馬抗体を用いた中枢作用型タンパク質・遺伝子医薬開発の最前線2013
- Author(s)
  黄倉崇、出口芳春
- Total Pages
  2
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-25460199
[Book] 遺伝子医学MOOK別冊-ペプチド・タンパク性医薬品の新規DDS製剤の開発と応用-2011
- Author(s)
  出口芳春
- Total Pages
  7
- Publisher
  メディカル・ドゥ
- Data Source
  KAKENHI-PROJECT-22590144
[Book] 遺伝子医学 MOOK 別冊 -ペプチド・タンパク性医薬品の新規 DDS 製剤の開発と応用2011
- Author(s)
  出口芳春
- Total Pages
  280
- Publisher
  メディカル・ドゥ
- Data Source
  KAKENHI-PROJECT-22590144
[Book] コンパス生物薬剤学(脳への移行、胎児への移行と胎盤関門)2010
- Author(s)
  出口芳春
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-22590144
[Book] 血液脳関門トランスポーターと創薬、トランスポーター科学の最前線、(辻彰編)2008
- Author(s)
  出口芳春
- Total Pages
  119
- Data Source
  KAKENHI-PROJECT-19590161
[Book] トランスポーター科学最前線2007
- Author(s)
  出口芳春
- Total Pages
  15
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-19590161
[Book] 分布(辻彰編)2007
- Author(s)
  出口芳春
- Total Pages
  98
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-19590161
[Book] Transport of basic peptides at the blood-brain barrier In Handbook of Biologically Active Peptides(Ed. by Abba J.Kastin)2006
- Author(s)
  Deguchi Y. et al.
- Publisher
  Elsevier, San Diego
- Data Source
  KAKENHI-PROJECT-16590123
[Book] In Handbook of Biologically Active Peptides, Et. by Abba J. Kastin, Elsevier, San Diego, pp. 1461-1466.2006
- Author(s)
  Deguchi Y. et al.
- Total Pages
  6
- Publisher
  Transport of basic peptides at the blood-brain barrier
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590123
[Journal Article] Expression and functional characterization of SLC transporters in brain microvascular endothelial cells derived from human induced pluripotent stem cells2019
- Author(s)
  Yuma Tega, Toshiki Kurosawa, Kei Higuchi, Tomoko Yamaguchi, Takashi Nakakura, Tatsuki Mochizuki, Hiroyuki Kusuhara, Kenji Kawabata, Yoshiharu Deguchi
- Journal Title
  
  Fluids and Barriers of the CNS
  
  Volume: 16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07231
[Journal Article] The Blood-Brain Barrier Transport Mechanism Controlling Analgesic Effects of Opioid Drugs in CNS2015
- Author(s)
  黄倉　崇、樋口　慧、出口芳春
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 135 Issue: 5 Pages: 697-702
- DOI
  10.1248/yakushi.14-00234-2
- NAID
  130005066918
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2015-05-01
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590213, KAKENHI-PROJECT-15K08080, KAKENHI-PROJECT-25460199
[Journal Article] Proton-Coupled Organic Cation Antiporter-Mediated Uptake of Apomorphine Enantiomers in Human Brain Capillary Endothelial Cell Line hCMEC/D32014
- Author(s)
  Okura T, Higuchi K, Kitamura A, Deguchi Y
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 37 Issue: 2 Pages: 286-291
- DOI
  10.1248/bpb.b13-00773
- NAID
  130003382121
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590213, KAKENHI-PROJECT-25460199
[Journal Article] Endothelin-1 Receptors in Rat Tissues: Characterization by Bosentan, Ambrisentan and CI-10202014
- Author(s)
  Yokoyama Y, Osano A, Hayashi H, Itoh K, Okura T, Deguchi Y, Ito Y, Yamada S
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 37 Issue: 3 Pages: 461-465
- DOI
  10.1248/bpb.b13-00881
- NAID
  130003390952
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460199
[Journal Article] Functional Expression of Organic Cation/carnitine Transporter 2 (OCTN2/<i>SLC22A5)</i> in Human Brain Capillary Endothelial Cell Line hCMEC/D3, a Human Blood-brain Barrier Model2014
- Author(s)
  Okura T, Kato S, Deguchi Y
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 29 Issue: 1 Pages: 69-74
- DOI
  10.2133/dmpk.DMPK-13-RG-058
- NAID
  130004463347
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590213, KAKENHI-PROJECT-25460199
[Journal Article] Characterization of the carriermediated transport of ketoprofen, a nonsteroidal anti-inflammatory drug, in rabbit cornea epithelium cells2013
- Author(s)
  Fujii S. Deguchi Y. et al
- Journal Title
  
  J. Pharm. Pharmacol
  
  Volume: 65 Pages: 171-180
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] Functional expression of a protoncoupled organic cation (H^+/OC) antiporter in humam brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model2013
- Author(s)
  Shimomura K, Okura T, Deguchi Y, et al
- Journal Title
  
  Fluids. Barrier. CNS
  
  Volume: 10:8 Pages: 1-10
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] Measurement of glomerular filtration rate by rapid intravenous injection of a newly developed insulin fraction2011
- Author(s)
  Maeda Y, Deguchi Y, et al
- Journal Title
  
  Journal of Rural Medicine
  
  Volume: 6 Pages: 9-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] The blood-brain barrier as a focus of drug metabolism and Pharmacokinetics2011
- Author(s)
  Deguchi Y
- Journal Title
  
  Drug Metab. Pharmacokin
  
  Volume: 26 Pages: 1-1
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodonein vitro and invivo2011
- Author(s)
  Sadiq, MW and Deguchi Y et al
- Journal Title
  
  J. Pharm. Sci
  
  Volume: 100 Pages: 3912-3923
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] The blood-brain barrier as a focus of drug metabolism and pharmacokinetics2011
- Author(s)
  Deguchi Y
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 26 Pages: 1-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] Measurement of glomerular filtration rate by rapid intravenous injection of a newly developed insulin fraction2011
- Author(s)
  Maeda Y and Deguchi Y et al
- Journal Title
  
  J. Rural Med
  
  Volume: 6 Pages: 9-15
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers2011
- Author(s)
  Okura T and Deguchi Y et al
- Journal Title
  
  J. Pharm. Sci
  
  Volume: 100 Pages: 3923-3938
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier and antinociceptive effect2010
- Author(s)
  Okura T, and Deguchi Y, et al
- Journal Title
  
  J. Pharm. Sci
  
  Volume: 99 Pages: 467-474
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier and antinociceptive effect.2010
- Author(s)
  Okura T, Deguchi Y, et al.
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 99 Pages: 467-474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone2008
- Author(s)
  Okura T, Hattori A, Takano Y, Sato T, Hammarlund-Udenaes M, Terasaki T, Deguchi Y.
- Journal Title
  
  Drug Metab. Dispos 36
  
  Pages: 2005-2005
- Data Source
  KAKENHI-PROJECT-19590161
[Journal Article] Involvement of the pyrilamine transporter, a putative organic cationtransporter, in blood-brain barrier transport of oxycodone.2008
- Author(s)
  Okura T, Deguchi Y, et al.
- Journal Title
  
  Drug Metab. Dispos. 36
  
  Pages: 2005-2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590161
[Journal Article] Comparative evaluation of antinociceptive potency of morphine and morphine-6ss-glucuronide by simultaneous measurements of spinal concentration2007
- Author(s)
  Okura T, Komiyama N, Morita Y, Deguchi Y, Yamada S.
- Journal Title
  
  Life Sci 80
  
  Pages: 1319-1319
- Data Source
  KAKENHI-PROJECT-19590161
[Journal Article] Blood-brain barrier transport of pramipexole, a dopamine D2 agonist2007
- Author(s)
  Okura T. Ito R, Ishiguro N, Tamai I, Deguchi Y.
- Journal Title
  
  Life Sci. 80
  
  Pages: 1564-1564
- Data Source
  KAKENHI-PROJECT-19590161
[Journal Article] Comparative measurement of spinal CSF microdialysate concentrations and concomitant antinociception of morphine and morphine-6b-glucuronide in rats2007
- Author(s)
  Okura T, Deguchi Y, et. al.
- Journal Title
  
  Life Science 80
  
  Pages: 1319-1326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590161
[Journal Article] Blood-brain barrier transport of pramipexole, a dopamine D2 agonist2007
- Author(s)
  Okura T, Deguchi Y, et. al.
- Journal Title
  
  Life Science 80
  
  Pages: 1564-1571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590161
[Journal Article] Transport of basic peptides at the blood-brain barrier2006
- Author(s)
  Deguchi Y. et al.
- Journal Title
  
  In Handbook of Biologically Active Peptides (Ed. by Abba J.Kastin) (Elsevier, San Diego)
  
  Pages: 1461-1466
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590123
[Journal Article] Blood-Brain Barrier Transport and Neuroprotective Effect of a novel cationic VIP analogue2005
- Author(s)
  Deguchi Y. et al.
- Journal Title
  
  Drug Metabol.Rev.Biotransform.Dispos.Xenobio. 37 suppl.2
  
  Pages: 273-273
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590123
[Journal Article] Blood-Brain Barrier Transport and Neuroprotective Effect of a novel cationic VIP analogue2005
- Author(s)
  Deguchi Y. et al.
- Journal Title
  
  Drug Metabol. Rev. Biotransform. Dispos. Xenobio. 37 Suppl. 2
  
  Pages: 273-273
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590123
[Journal Article] Blood-Brain Barrier Transport and Neuroprotective Effect of a novel cationic VIP analogue2005
- Author(s)
  Deguchi Y. et al.
- Journal Title
  
  Drug Metabol.Rev.Biotransform.Dispos.Xenobio. 37 Suppl.2
  
  Pages: 273-273
- Data Source
  KAKENHI-PROJECT-16590123
[Journal Article] Blood-brain barrier permeability of novel [D-Arg^2]dermorphin (1-4) analogues2004
- Author(s)
  Deguchi Y. et al.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 310(1)
  
  Pages: 177-184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590123
[Journal Article] Blood-brain barrier permeability of novel [D-Arg^2]dermorphin (1-4) analogues2004
- Author(s)
  Deguchi Y. et al.
- Journal Title
  
  J. Pharmacol. Exp. Ther. 310(1)
  
  Pages: 177-184
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590123
[Patent] 多能性幹細胞由来脳血管内皮細胞及びその製造方法2022
- Inventor(s)
  川端健二、山口朋子、出口芳春
- Industrial Property Rights Holder
  川端健二、山口朋子、出口芳春
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-178573
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-23K24052
[Patent] 多能性幹細胞由来脳毛細血管内皮細胞及びその製造方法2021
- Inventor(s)
  川端健二、山口朋子、出口芳春
- Industrial Property Rights Holder
  川端健二、山口朋子、出口芳春
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-178573
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K07231
[Presentation] ヒトiPS細胞由来脳毛細血管内皮細胞におけるP-gpの発現および機能の改善2022
- Author(s)
  佐孝大樹、黒澤俊樹、山口朋子、宮野綾華、久保義行、川端健二、大槻純男、出口芳春、ヒトiPS細胞由来脳毛細血管内皮細胞におけるP-gpの発現および機能の改善
- Organizer
  第37回　日本薬物動態学会年会（横浜）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24052
[Presentation] MDR1遺伝子導入ヒトiPS細胞由来血液脳関門モデル細胞の作製と機能解析2022
- Author(s)
  佐孝大樹、黒澤俊樹、山口朋子、宮野綾華、久保義行、川端健二、大槻純男、出口芳春
- Organizer
  第43回　生体膜と薬物の相互作用シンポジウム（北海道）
- Data Source
  KAKENHI-PROJECT-23K24052
[Presentation] P-gp発現ヒトiPS細胞由来脳毛細血管内皮細胞における輸送体機能評価2022
- Author(s)
  佐孝大樹、黒澤俊樹、山口朋子、久保義行、川端健二、出口芳春
- Organizer
  日本薬学会第142年会（名古屋）
- Data Source
  KAKENHI-PROJECT-19K07231
[Presentation] ヒトiPS細胞由来血液脳関門モデルのMPSへの展開2022
- Author(s)
  出口芳春、黒澤俊樹、佐孝大樹、久保義行
- Organizer
  第37回　日本薬物動態学会年会（横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-23K24052
[Presentation] ヒトiPS細胞由来血液脳関門モデル細胞を用いた3次元フロー培養システムの構築2022
- Author(s)
  黒澤俊樹、佐孝大樹、出堀泰之、冨原裕美、青山和誠、天野信之、久保義行、出口芳春
- Organizer
  第43回　生体膜と薬物の相互作用シンポジウム（北海道）
- Data Source
  KAKENHI-PROJECT-23K24052
[Presentation] ヒトiPS細胞由来脳毛細血管内皮細胞を用いた3次元BBB-on-a-chipの構築と評価2022
- Author(s)
  黒澤俊樹、手賀悠真、佐孝大樹、出堀泰之、冨原裕美、青山和誠、久保義行、天野信之、出口芳春
- Organizer
  細胞アッセイ研究会シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07231
[Presentation] ２次元および３次元培養ヒトiPS細胞由来血液脳関門モデルを用いたトランスポーター機能評価2021
- Author(s)
  黒澤俊樹、出口芳春
- Organizer
  第36回　日本薬物動態学会年会（高崎）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07231
[Presentation] ヒトiPS細胞由来脳毛細血管内皮細胞を用いた3次元実験モデルの構築2021
- Author(s)
  黒澤俊樹、手賀悠真、佐孝大樹、出堀泰之、冨原裕美、天野信之、出口芳春
- Organizer
  日本薬剤学会第36年会（徳島）
- Data Source
  KAKENHI-PROJECT-19K07231
[Presentation] 3次元培養におけるヒトiPS細胞由来脳毛細血管内皮細胞のLAT1の輸送機能2021
- Author(s)
  佐孝大樹、黒澤俊樹、手賀悠真、出堀泰之、久保義行、天野信之、出口芳春
- Organizer
  第36回日本薬物動態学会年会（高崎）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07231
[Presentation] P糖タンパク質欠損が血液脳関門恒常性に与える影響2020
- Author(s)
  古西修希、出口芳春、et al.
- Organizer
  日本薬剤学会第35年会（熊本）
- Data Source
  KAKENHI-PROJECT-19K07231
[Presentation] ヒトiPS細胞由来血液脳関門モデルを用いた6-mercaptopurineの輸送機構解析2020
- Author(s)
  黒澤俊樹、出口芳春、et al.
- Organizer
  日本薬剤学会第35年会（熊本）
- Data Source
  KAKENHI-PROJECT-19K07231
[Presentation] Human BBB-on-a-chipによる化合物の中枢移行性評価2020
- Author(s)
  出口芳春
- Organizer
  第27回HAB研究機構学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07231
[Presentation] Evaluation of Transporter Function in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.2019
- Author(s)
  Toshiki Kurosawa, Yuma Tega, Tomoko Yamaguchi, Tatsuki Mochizuki, Yasuhiro Hayashi, Atsushi Yamashita, Hiroyuki Kusuhara, Kenji Kawabata, Yoshiharu Deguchi
- Organizer
  The 6th International Symposium on BioimagingThe 28th Annual Meeting of the Bioimaging Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07231
[Presentation] ヒトiPS由来脳毛細血管内皮細胞におけるP糖タンパク質の発現誘導2019
- Author(s)
  佐孝大樹、黒澤俊樹、手賀悠真、高野真史、橘高敦史、出口芳春
- Organizer
  第63回薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K07231
[Presentation] Functional investigation of SLC35F2 as a drug transporterin primate blood brain barrier model cells.2019
- Author(s)
  Tatsuki Mochizuki, Tadahaya Mizuno, Kei Higuchi, Yuma Tega, Toshiki Kurosawa, Tomoko Yamaguchi, Kenji Kawabata, Yoshiharu Deguchi, Hiroyuki Kusuhara
- Organizer
  第34日本薬物動態学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07231
[Presentation] ヒトiPS細胞由来脳毛細血管内皮細胞における6-mercaptopurineの輸送機構解析2019
- Author(s)
  黒澤俊樹、手賀悠真、山口朋子、川端健二、望月達貴、井上勝央、楠原洋之、出口芳春
- Organizer
  第41回　生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07231
[Presentation] ヒトiPS細胞由来脳毛細血管内皮細胞におけるトランスポーターの機能的発現2018
- Author(s)
  8.手賀悠真、黒澤俊樹、樋口　慧、山口朋子、川端健二、出口芳春
- Organizer
  日本薬剤学会第33 年会（静岡）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] Investigation of SLC35F2 drug transport function in mouse brain and primate BBB models.2018
- Author(s)
  4.Tatsuki Mochizuki, Tadahaya Mizuno, Kei Higuchi, Yuma Tega, Toshiki Kurosawa, Tomoko Yamaguchi, Kenji Kawabata, Yoshiharu Deguchi, Hiroyuki Kusuhara
- Organizer
  第33JSSX第22MDO合同年会（金沢）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] 血液脳関門透過性を有するヒストン脱アセチル化酵素阻害剤の探索研究2018
- Author(s)
  2.住吉孝明，平中誠弥，手賀悠真，樋口慧，黒澤俊樹，出口芳春，本間光貴，新真由美，伊藤昭博，吉田稔，長岡康夫
- Organizer
  第36回メディシナルケミストリーシンポジウム（京都）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] ヒト血液脳関門モデル細胞を用いたH+/有機カチオン交換輸送体の基質スクリーニング2018
- Author(s)
  1.手賀悠真，北村　敦，大町蕗子，黒澤俊樹，樋口慧，板垣文雄，出口芳春
- Organizer
  第３回トランスポーター研究会関東部会（千葉）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] Characterization of mesoridazine transport in human cerebral microvessel endothelial cells, hCMEC/D32018
- Author(s)
  6.Yasuyuki Debori1, Tomoko Igari, Masanori Nakakariya, Nobuyuki Amano, Yuma Tega, Kei Higuchi, Takashi Okura and Yoshiharu Deguchi
- Organizer
  第33JSSX第22MDO合同年会（金沢）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] ゲノム編集ヒト血液脳関門細胞における薬物輸送機能評価2018
- Author(s)
  7.樋口　慧、手賀悠真、黒澤俊樹、濱弘太郎、横山和明、出口芳春
- Organizer
  日本薬剤学会第33 年会（静岡）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] Screening of proton-coupled organic cation antiporter substrates using hCMEC/D3 cells: an in vitro human blood-brain barrier model2018
- Author(s)
  5.Atsushi Kitamura, Yuma Tega, Toshiki Kurosawa, Kei Higuchi, Yoshiharu Deguchi
- Organizer
  第33JSSX第22MDO合同年会（金沢）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] CRISPR-Cas9システムを用いたヒト血液脳関門細胞の排出輸送系ノックアウト2017
- Author(s)
  樋口　慧、手賀悠真、黒澤俊樹、濱弘太郎、横山和明、出口芳春
- Organizer
  日本薬学会第137年回（仙台）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] ヒトiPS由来脳毛細血管内皮細胞における薬物輸送能の解明2017
- Author(s)
  黒澤俊樹、手賀悠真、樋口　慧、山口朋子、川端健二、出口芳春
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム（金沢）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] Gene expression and　function of drug transporters in brain microvascular endothelial cells derived from human iPS cells2017
- Author(s)
  Toshiki Kurosawa, Yuma Tega, Kei Higuchi, Tomoko Yamaguchi, Kenji Kawabata, Yoshiharu Deguchi
- Organizer
  第32日本薬物動態学会年会（東京）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] ヒト血液脳関門プロトン/有機カチオンアンチポーターの機能制御因子の解析2017
- Author(s)
  樋口　慧、近藤麻美、上松祐貴、黒澤俊樹、黄倉　崇、出口芳春
- Organizer
  日本薬学会第137年回
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] ヒト血液脳関門プロトン/有機カチオンアンチポーターの機能制御因子の解析2017
- Author(s)
  〇樋口　慧、近藤麻美、上松祐貴、黒澤俊樹、黄倉　崇、出口芳春
- Organizer
  日本薬学会第137年会
- Place of Presentation
  宮城県仙台市仙台国際センター
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] H+/有機カチオン交換輸送体を標的としたHDAC阻害剤の脳へのデリバリー2017
- Author(s)
  手賀悠真、平中誠弥、樋口慧、出口芳春、伊藤昭博、吉田稔、長岡康夫、住吉孝明
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム（金沢）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] 血液脳関門におけるバレニクリンの輸送解析2016
- Author(s)
  樋口　慧、黒澤俊樹、黄倉　崇、楠原洋之、出口芳春
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム（名古屋）
- Place of Presentation
  名古屋
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] Transport characteristics of varenicline in the blood-brain barrier2016
- Author(s)
  Kurosawa T, Higuchi K, Okura T, Kusuhara H, Deguchi Y.
- Organizer
  日本薬物動態学会第31年会
- Place of Presentation
  長野県松本市キッセイ文化ホール
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Transport characteristics of varenicline in the blood-brain barrier2016
- Author(s)
  Toshiki Kurosawa, Kei Higuchi, Takashi Okura, Hiroyuki Kusuhara, and Yoshiharu Deguchi
- Organizer
  第31日本薬物動態学会年会（松本）
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] Histamine H1-receptor signaling in human blood-brain barrier cells2015
- Author(s)
  Takashi Okura, Kei Higuchi, Manami Ueno , Hironao Ito, Asami Kondo, Yoshiharu Deguchi
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  東京（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Blood-to-brain transport of apomorphine enantiomers by proton-coupled organic cation antiporter at the blood-brain barrier2015
- Author(s)
  Okura T, Higuchi K, Kitamura A, Deguchi Y
- Organizer
  11th International Conference on Cerebral Vascular Biology
- Place of Presentation
  Paris (France)
- Year and Date
  2015-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Gene expression profiles in hCMEC/D3 cells with different transport activities of proton/organic cation antiporter2015
- Author(s)
  Kei Higuchi, Takashi Okura, Yuki Uematsu, Asami Kondo, Hironao Ito, Yoshiharu Deguchi
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  東京（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Histamine H1-receptor signaling in human blood-brain barrier cells2015
- Author(s)
  Okura T, Higuchi K, Ueno M, Ito H, Kondo A, Deguchi Y
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Analysis of gene expression profiles related to the transport activity of the proton/organic cation antiport system in hCMEC/D3 cells2015
- Author(s)
  Higuchi K, Okura T, Uematsu Y, Kondo A, Ito H, Deguchi Y
- Organizer
  Barcelona BioMed Conference, Blood Brain Barrier
- Place of Presentation
  Barcelona (Spain)
- Year and Date
  2015-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Gene expression profiles in hCMEC/D3 cells with different transport activities of proton/organic cation antiporter2015
- Author(s)
  Higuchi K, Okura T, Uematsu Y, Kondo A, Ito H, Deguchi Y
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Memantine uptake mediated by a functionally diverse proton-coupled organic cation antiporter in human brain endothelial cells2015
- Author(s)
  Higuchi K, Okura T, Deguchi Y
- Organizer
  The Asian Federation for Pharmaceutical Sciences (AFPS) Conference 2015
- Place of Presentation
  Bangkok (Thailand)
- Year and Date
  2015-11-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Involvement of functionally diverse proton-coupled organic cation antiporter in blood-brain barrier transport of memantine2015
- Author(s)
  Kei Higuchi, Atsushi Kitamura, Takashi Okura, Yoshiharu Deguchi
- Organizer
  11th Cerebral Vascular Biology International Conference
- Place of Presentation
  パリ
- Year and Date
  2015-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Blood-to-brain transport of apomorphine enantiomers by proton-coupled organic cation antiporter at the blood-brain barrier2015
- Author(s)
  Takashi Okura, Kei Higuchi, Atsushi Kitamura, Yoshiharu Deguchi
- Organizer
  11th Cerebral Vascular Biology International Conference
- Place of Presentation
  パリ
- Year and Date
  2015-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Involvement of functionally diverse proton-coupled organic cation antiporter in blood-brain barrier transport of memantine2015
- Author(s)
  Higuchi K, Kitamura A, Okura T, Deguchi Y
- Organizer
  11th International Conference on Cerebral Vascular Biology
- Place of Presentation
  Paris (France)
- Year and Date
  2015-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] 麻薬性鎮痛薬の中枢効果を制御する血液脳関門輸送機構2014
- Author(s)
  黄倉　崇、樋口　慧、出口芳春
- Organizer
  日本薬学会第134年会シンポジウム
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] アポモルヒネの高い脳移行性を担う血液脳関門輸送のインビボ解析2014
- Author(s)
  黄倉　崇、佐藤樹夏、樋口　慧、北村　敦、柄谷礼人、久保敬史、小林俊生、櫻庭美菜子、出口芳春
- Organizer
  第58回薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] hCMEC/D3細胞を用いたカクテル法によるH+/有機カチオン交換輸送体基質探索の基礎的検討2014
- Author(s)
  樋口　慧、北村　敦、黄倉　崇、出口芳春
- Organizer
  日本薬学会第13４年会
- Place of Presentation
  熊本大学（熊本）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] 脳マイクロダイアリシス法による薬物カクテルの脳移行性評価2014
- Author(s)
  北村敦、黒澤俊樹、樋口慧、黄倉崇、福島貴人、祖父江佳奈、出口芳春
- Organizer
  第58回薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] 尿酸トランスポーターURAT1の脳内局在解析2013
- Author(s)
  富岡　直子, 道志　勝, 市田公美, 森崎隆幸, 出口芳春, 細山田　真
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] A proton-coupled organic cation antiporter mediated transport of apomorphine in human brain endothelial cell line hCMEC/D32013
- Author(s)
  Takashi Okura, Kei Higuchi, Atsushi Kitamura, Yoshiharu Deguchi
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] 尿酸トランスポーターURAT1 の脳内局在解析2013
- Author(s)
  富岡直子、出口芳春ら
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] R(-)-Apomorphine transport into human brain endothelial cells by a proton-coupled organic cation antiporter2013
- Author(s)
  Takashi Okura, Kei Higuchi, Atsushi Kitamura, Yoshiharu Deguchi
- Organizer
  第28回日本薬物動態学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] ヒト血液脳関門におけるアポモルヒネのプロトン交換輸送機構2013
- Author(s)
  黄倉　崇、樋口慧、出口芳春
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインク愛知（名古屋）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] トランスポーターを利用した薬物の脳移行　－ヒト血液脳関門におけるメマンチンの輸送機構解析－2013
- Author(s)
  樋口　慧、黄倉　崇、出口芳春
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインク愛知（名古屋）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] ヒト血液脳関門におけるアポモルヒネのプロトン交換輸送機構2013
- Author(s)
  黄倉　崇、樋口　慧、出口芳春
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] ヒト血液脳関門細胞hCMEC/D3におけるメマンチンの輸送特性2013
- Author(s)
  樋口　慧、北村敦、黄倉　崇、出口芳春
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Investigation of the organic cation/carnitine transporter in human brain endothelial cells by small interfering RNA2012
- Author(s)
  Okura T and Deguchi Y
- Organizer
  第27回日本薬物動態学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒト脳毛細血管内皮細胞(hCMEC/D3) を用いた有機カチオン/カルニチントランスポーターの機能解析2012
- Author(s)
  黄倉崇、加藤清香、出口芳春
- Organizer
  日本薬剤学会第27 年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] The existence of H^+-coupled organic cation antiporter (the pyrilamine transporter) at the in vitro human blood-brain barrier cells2012
- Author(s)
  Deguchi Y, et al
- Organizer
  薬物動態国際シンポジューム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒト脳毛細血管内皮細胞株（hCMEC/D3）を用いた有機カチオン/カルニチントランスポーターの機能解析2012
- Author(s)
  黄倉　崇、加藤清香、出口芳春
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] Investigation of the organic cation/carnitine transporter in human brain endothelial cells by small interfering RNA2012
- Author(s)
  Takashi Okura, Yoshiharu Deguchi
- Organizer
  第27回日本薬物動態学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] In vitro試験に基いたヒト脳D2受容体占有率の予測2012
- Author(s)
  呉　春勇、楠原洋之、出口芳春、杉山雄一
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒト脳毛細血管内皮細胞株 hCMEC/D3 を用いたカチオン性薬物のヒト血液脳関門透過性予測の試み2012
- Author(s)
  黄倉崇、樋口慧、出口芳春ら
- Organizer
  日本動物実験代替学会第25回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒト脳毛細血管内皮細胞株hCMEC/D3を用いたカチオン性薬物のヒト血液脳関門透過性予測の試み2012
- Author(s)
  黄倉　崇、下村慶太、樋口慧、Pierre-Oliver Couraud、出口芳春
- Organizer
  日本動物実験代替学会第25回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] In vitro 試験に基いたヒト脳 D2 受容体占有率の予測2012
- Author(s)
  呉春勇、楠原洋之、出口芳春、杉山雄一
- Organizer
  日本薬剤学会第27 年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒト脳毛細血管内皮細胞(hCMEC/D3)を用いた有機カチオン/カルニチントランスポーターの機能解析2012
- Author(s)
  黄倉崇、加藤清香、出口芳春
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒト脳毛細血管内皮細胞株hCMEC/D3を用いたカチオン性薬物のヒト血液脳関門透過性予測の試み2012
- Author(s)
  黄倉崇、下村慶太、樋口　慧、Pierre-Oliver Couraud、出口芳春
- Organizer
  日本動物実験代替学会第25回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒト血液脳関門細胞における有機カチオン関連トランスポーターの発現と機能2011
- Author(s)
  黄倉崇、出口芳春, ら
- Organizer
  日本薬学会131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo2011
- Author(s)
  Deguchi Y, et al
- Organizer
  Asian Federation of Pharmaceutical Science 2011
- Place of Presentation
  Kuala Lumpur
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] RNA干渉法を用いたヒト血液脳関門細胞における有機カチオン輸送体の機能解析2011
- Author(s)
  黄倉崇、出口芳春, ら
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] RNA 干渉法を用いたヒト血液脳関門細胞で機能する有機カチオン輸送体の探索2011
- Author(s)
  黄倉崇、出口芳春ら
- Organizer
  第6回トランスポーター研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] RNA 干渉法を用いたヒト血液脳関門細胞における有機カチオン輸送体の機能解析2011
- Author(s)
  黄倉崇、出口芳春ら
- Organizer
  日本薬剤学会第26 年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] マウス血液脳関門およびグリア細胞におけるカチオントランスポーターの局在解析2011
- Author(s)
  森本理代、出口芳春ら
- Organizer
  日本薬学会 131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] Localization and functional roles of organic cation/carnitine transporter at the blood-brain barrier2011
- Author(s)
  Sayaka K, Deguchi Y, et al
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒト血液脳関門細胞における有機カチオン関連トランスポーターの発現と機能2011
- Author(s)
  黄倉崇、出口芳春ら
- Organizer
  日本薬学会 131 年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] RNA干渉法を用いたヒト血液脳関門細胞で機能する有機カチオン輸送体の探索2011
- Author(s)
  黄倉崇、出口芳春, ら
- Organizer
  第6回トランスポーター研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] マウス血液脳関門およびグリア細胞におけるカチオントランスポーターの局在解析2011
- Author(s)
  森本理代、出口芳春, ら
- Organizer
  日本薬学会131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] 脳関門システムにおけるカチオントランスポーターの局在解析2011
- Author(s)
  森本理代、出口芳春, ら
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] 脳関門システムにおけるカチオントランスポーターの局在解析2011
- Author(s)
  森本理代、出口芳春ら
- Organizer
  日本薬剤学会第26 年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] Drug-drug interactions between oxycodone and adjuvant analgesics at the blood-brain barrier2009
- Author(s)
  Takashi Okura, Yusuke Nakazawa, Asami Hattori, Tetsuya Terasaki and Yoshiharu Deguchi
- Organizer
  8th ISSX/22th JSSX Joint Meeting
- Place of Presentation
  abstract
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Expression and functional characterization of plasma membrane monoamine transporter(PMAT)in the rat BBB2008
- Author(s)
  Yoshiharu Deguchi, et.al.
- Organizer
  11^<th> International SymPosium on Signal Transduction in the Blood-Brain Barrier
- Place of Presentation
  オランダ・アムステルダム
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Plasma membrane monoamine transporter (PMAT) mediates the efflux transport of organic cations in the brain barrier system2008
- Author(s)
  Takenori Sato, Yoshiharu Deguchi, et al
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Takashi Okllra Yoshiharu Deguchi et.al.2008
- Author(s)
  Takashi Okllra Yoshiharu Deguchi et.al.
- Organizer
  11^<th> International Symposium on Signal Transduction in the Blood-Brain Barrier
- Place of Presentation
  オランダ・アムステルダム
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Plasma membrane monoamine trans- Porter(PMAT)mediates the efflux transport of org anic cations in the brain barrier system2008
- Author(s)
  Takenori Sato, Yoshiharu Deguchi.et.al.
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] 血液脳関門に高発現する新規有機カチオントランスポーター(PMAT)のクローニングと輸送機能解析2008
- Author(s)
  高野祐輔、黄倉崇、出口芳春ら
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] The pyrilamine transporter functions as the multispecific organic cation transporter at the blood-brain barrier2008
- Author(s)
  Keita Shimomura, Yoshiharu Deguchi, et al
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] カチオントランスポーターPMATの脳関門における発現と輸送機能解析2008
- Author(s)
  佐藤武則, 出口芳春, 他
- Organizer
  日本薬剤学会第23年会
- Place of Presentation
  札幌
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Expression and functional characterization of plasma membrane monoamine transporter (PMAT) in the rat blood-brain barrier2008
- Author(s)
  Yoshiharu Deguchi, et al
- Organizer
  11^<th> International Symposium on Signal Transduction in the Blood-Brain Barrier
- Place of Presentation
  オランダ・アムステルダム
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] The pyrilamine transPorter functions as the multispecific organic cation transporter at the blood-brain barrier2008
- Author(s)
  Keita Shimomura, Yoshiharu Deguchi et.al.
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Blood-brain barrier transport and pharmacological effect of opioids2008
- Author(s)
  Takashi Okura, Yoshiharu Deguchi, et al
- Organizer
  11^<th> International Symposium on Signal Transduction in the Blood-Brain Barrier
- Place of Presentation
  オランダ・アムステルダム
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Involvement of H+/organic cation antiporter in the blood-brain barrier transport of cationic drugs2007
- Author(s)
  Yoshiharu Deguchi
- Organizer
  10th International Symposium, Signal Transduction in the Blood-Brain Barrier
- Place of Presentation
  Postdam/Germany
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Blood-brain barrier transport of oxycodone, an opioid receptor agonist2007
- Author(s)
  Asami Hattori, Takashi Okura, Yusuke Nakazawa Margareta Hammarlund-Udenaes, Tetsuya Terasaki, Yoshiharu Deguchi
- Organizer
  The 5th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects, Shizuoka p.95
- Place of Presentation
  abstract form
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Involvement of H+/0rganic cation antiporter in the blood-brain barrier transport of cationic drugs2007
- Author(s)
  Deguchi Y
- Organizer
  10th International Symposium, Signal Transduction in the Blood-Brain Barrier
- Place of Presentation
  Postdam/Germany
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] H+/organic cation antiporter is involved in the blood-brain barrier transport of cationic drugs2007
- Author(s)
  Deguchi Y, et. al.
- Organizer
  4th World Conference on Drug Absorption, Transport and Delivery
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Expression and transport function of ratplasma membrane transporter(rPMAT)in the brain barrler system2007
- Author(s)
  黄倉崇、出口芳春ら
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] 血液脳関門におけるカチオン性薬物トランスポーターの機能および輸送分子の解析2007
- Author(s)
  出口芳春、黄倉崇、服部麻美、鈴木俊英、寺崎哲也
- Organizer
  講演要旨集.p.405(2007)
- Place of Presentation
  日本薬剤学会(大宮)
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] 麻薬性鎮痛薬オキシコドンと鎮痛補助薬の相互作用解析2007
- Author(s)
  黄倉崇、中澤佑介、服部麻美、寺崎哲也、出口芳春
- Organizer
  講演要旨集, p.343(2007)
- Place of Presentation
  日本薬剤学会(大宮)
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] H+/organic cation antiporter is involved in the blood-brain barrier transport of cationic drugs2007
- Author(s)
  Yoshiharu Deguchi, Takashi Okura, et.al.
- Organizer
  4th World Conference on Drug Absorption, Transport and Delivery
- Place of Presentation
  Kanazawa
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] 血液脳関門におけるカチオン性薬物トランスポーターの機能および輸送分子の解析2007
- Author(s)
  出口芳春, ら
- Organizer
  日本薬剤学会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] 脳関門におけるrat plasmame mebrane transporter(rPMAT)の発現と輸送機能2007
- Author(s)
  高野祐輔、黄倉崇、出口芳春ら
- Organizer
  トランスポーター研究会第1回関東部会
- Place of Presentation
  横浜
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] ヒト血液脳関門のトラマドール輸送における
- Author(s)
  北村　敦、樋口　慧、黄倉　崇、出口　芳春
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  帝京大学板橋キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] IN VIVO AND IN VITRO TRANSPORT OF APOMORPHINE ENANTIOMERS ACROSS THE BLOOD-BRAIN BARRIER
- Author(s)
  Kitamura A, Higuchi K, Okura T, Deguchi Y
- Organizer
  19th North American ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] 脳マイクロダイアリシス法を用いたカクテル投与による薬物の脳移行性評価
- Author(s)
  北村敦、樋口慧、黄倉崇、祖父江佳奈、福島貴人、出口芳春
- Organizer
  日本薬剤学会第29年回
- Place of Presentation
  埼玉
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] A proton-coupled organic cation antiporter mediated transport of apomorphine in human brain capillary endothelial cell line hCMEC/D3
- Author(s)
  Takashi Okura, Kei Higuchi, Atsushi Kitamura, Yoshiharu Deguchi
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東北大学片平キャンパス(仙台）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] TRANSPORT CHARACTERISTICS OF TRAMADOL AT THE BLOOD-BRAIN BARRIER
- Author(s)
  Yoshiharu Deguchi, Atsushi Kitamura, Kei Higuchi, Takashi Okura
- Organizer
  19ｔｈ North American ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] TRANSPORT CHARACTERISTICS OF TRAMADOL AT THE BLOOD-BRAIN BARRIER
- Author(s)
  Deguchi Y, Kitamura A, Higuchi K, Okura T
- Organizer
  19th North American ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] IN VIVO AND IN VITRO TRANSPORT OF APOMORPHINE ENANTIOMERS ACROSS THE BLOOD-BRAIN BARRIER
- Author(s)
  Takashi Okura, Kei Higuchi, Atsushi Kitamura, Yoshiharu Deguchi
- Organizer
  19ｔｈ North American ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] プロトン交換輸送体によるアポモルヒネのヒト血液脳関門輸送
- Author(s)
  黄倉　崇、樋口　慧、北村敦、出口芳春
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  タワーホール船堀（東京
- Data Source
  KAKENHI-PROJECT-25460199
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]

1. OKURA Takashi (80326123)

# of Collaborated Projects: 6 results

# of Collaborated Products: 69 results
2. HIGUCHI Kei (10625304)

# of Collaborated Projects: 4 results

# of Collaborated Products: 40 results
3. 黒澤俊樹 (90839466)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
4. 川端健二 (50356234)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. KATO Sayaka (70505940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. HOSOYAMADA MAKOTO (00291659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMASHITA Atsushi (80230415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 平田圭一 (80424852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中谷絵理子 (90803916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 手賀悠真 (50809043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
11. 安楽泰孝 (60581585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 劉学瑩 (30777470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 杉山雄一 (80090471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 前田和哉 (00345258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 加藤将夫 (30251440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 吉門崇 (70535096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 萩原将也 (00705056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 久保義行 (20377427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
19. 功刀浩 (40234471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Yamaguchi Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
21. Kusuhara Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

DEGUCHI Yoshiharu 出口 芳春

DEGUCHI Yoshlharu 出口 芳春

Research Projects

Research Products

Co-Researchers

医薬工の技術連携による脳関門統合マイクロ生体模倣システムの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳内神経細胞への抗体医薬送達を実現するtransfer DDSの創出

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated development of quantitative prediction methods for complex drug-drug interactions involving transporters

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Creation and clinical application of 3D brain barrier chips using human iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional elucidation of human blood-brain barrier using iPS-derived brain microvascular entdothelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the drug recognition properties and molecular entities of the organic cation-proton exchange system at the human blood-brain barrierPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transport aross the blood-brain barrier in relation to CNS actions of opioid analgesics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel experimental evaluation method for predicting the drug delivery to the brain in humanPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Blood-Brain Barrier Transport Mechanism Controlling Analgesic Effects of Opioid Drugs in the Central Nervous System

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prediction of the human brain distribution for the central nervous system drugs using a novel human immortalized brain capillary endothelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and Functional Characterization of Pyrilamine Transporter, an Organic Cation TransporterPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional Changes in the Blood-Brain Barrier and Neuroprotective Effects in the Brain IschemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional and Molecular Analysis of Peptide/Protein Transport System in the Blood-Brain BarrierPrincipal Investigator

Principal Investigator

Project Period (FY)

DEGUCHI Yoshiharu 出口芳春

DEGUCHI Yoshlharu 出口芳春

[Book] 薬物分布実験法　脳関門2014

[Book] 細胞工学　トロイの木馬抗体を用いた中枢作用型タンパク質・遺伝子医薬開発の最前線2013