SAKUMA Ichiro 佐久間一郎

Researcher Number	40260393
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2004: 北海道大学, 医学部付属病院, 講師 2004: Hokkaido Univ., Cardiovascular Med., Assistant Professor, 医学部附属病院, 講師 2004: Hokkaido University Hospital, Lec., 病院, 講師 2003: 北海道大学, 医学部・歯学部付属病院, 講師 2003: 北海道大学, 医学部・歯学部附属病院, 講師 … More 2002: 北海道大学, 医学部附属病院, 講師 1999 – 2001: 北海道大学, 医学部・附属病院, 講師 1999: Hokkaido University, School of Medicine, Assistant Professor, 医学部, 講師 1997 – 1998: 北海道大学, 医学部, 助手 1994 – 1995: 北海道大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies / Obstetrics and gynecology / Circulatory organs internal medicine / Public health/Health science Except Principal Investigator Gender / Psychiatric science / Anesthesiology/Resuscitation studies / Circulatory organs internal medicine / Obstetrics and gynecology
Keywords	Principal Investigator S-ニトロソヘモグロビン / 一酸化窒素 / ヘモグロビン修飾体 / 人工赤血球 / パーフルオロカーボン / ポリエチレングリコール / 血小板粘着能 / 血小板凝集能 / nitric oxide / artificial red blood cell … More / Advanced glycosylation endproduct / 卵巣摘出 / ラット / エストロゲン / PERFLUOROCARBON / S-NITROSOHEMOGLOBIN / POLYETHYLENE GLYCOL / PLATELET ADHESIBILITY / PLATELET AGGRIGABILITY / NITRIC OXIDE / MODIFIED HEMOGLOBIN / ARTIFICIAL RED BLOOD CELL / ヘモクロビン修飾体 / perfluorocarbon / s-nitrosohemoglobin / polyethylene glycol / platelet adhesion / platelet aggregation / hemoglobin derivative / connexin / ovariectomy / estrogen / resting membrane potential / mesenteric artery / rat / potassium channel / endothelium-derived hyperpolarizing factor / 腸間脈動脈 / カリウムチャネル / コネキシン / 静止膜電位 / 腸間膜動脈 / カリウムチャンネル / 内皮由来過分極因子 / microdialysis method / S-nitrosohemoglobin / vascular endothelial cell / artificial oxygen carrier / modified hemoglobin / 人工酸素供与体 / マイクロダイアリシス法 / 血管内皮細胞 / 人工酸素体 / Plasminoge activator inhibitor-1 / Coronary microvasculopathy / Acetylcholine / Insulin / Endothelium-derived hyperpolarizing factor / Aminoguanidine / Diabetes mellitus / β交感神経 / 心臓 / advanced glycosylation endproduct / Plasminogen activator inhibitor-1 / 冠微小血管障害 / アセチルコリン / インスリン / 内皮依存性過分極因子 / アミノグアニジン / 糖尿病 / アポトーシス / eNOS / VEGF / 脳血管 / 冠動脈 / 医療経済学 / 医療統計学 / 医療費 / アルツハイマー病 / 骨粗鬆症 / 虚血性心疾患 / ホルモン補充療法 / 女性ホルモン … More Except Principal Investigator Atherosclerosis / 一酸化窒素 / エストロゲン受容体 / Metabolic Syndrome / Single Nucleotide Polymorphism / Comprehensive Geriatric Assessment / Postmenopausal Women / Hormone Replacement Therapy / 遺伝子解析 / 動脈硬化症 / メタボリック症候群 / 遺伝子変異 / 高齢者総合機能評価 / 閉経後女性 / ホルモン補充療法 / gonadectomy / frontal cortex / estrogen receptors / androgen receptors / neurosteroids / HD / AD / 血管増殖因子 / ADHDモデルラット / 軽度発達障害 / 去勢 / 大脳前頭皮質機能 / アンドロゲン受容体 / 神経ステロイド / 多動性障害 / 注意欠陥 / perfluorocarbon / s-nitrosohemoglobin / polyethylene glycol / platelet adhesion / platelet aggregation / nitric oxide / hemoglobin derivative / artificial red blood cell / セロトニン / パーフルオロカーボン / S-ニトロソヘモグロビン / ポリエチレングリコール / 血小板粘着能 / 血小板凝集能 / ヘモグロビン修飾体 / 人工赤血球 / Adeno Virus / Gene Therapy / Inducible nitric oxide synthase / Endothelial nitric oxide synthase / 構造機能解析 / 一酸化窒素合成酵素 / 血管内超音波 / 遺伝子導入 / 動脈硬化退縮 / アデノウイルス / 動脈硬化 / 遺伝子治療 / 誘導型NO合成酵素 / 内皮型NO合成酵素 / caspase-3 / Akt / eNOS / KDR / VEGF / 脳毛細血管 / 遺伝子改変マウス Less

A Study on Mechanisms of Regional Differences of Side Effects of Hormone Replacement Treatment (HRT)
- Principal Investigator
  
  HAYASHI Toshio
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gender
- Research Institution
  Nagoya University
脳毛細血管構築制御に関わるエストロゲン受容体サブタイプの遺伝子改変動物による解明
- Principal Investigator
  
  服部裕一
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hokkaido University
Pathophysiological roles of Neurosteroids in an animal model of attention-deficit/hyperacivity disorder
- Principal Investigator
  
  TOGASHI Hiroko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  HOKKAIDO UNIVERSITY
エストロゲンによる心臓および脳毛細血管網構築の制御とその生理的役割に関する研究Principal Investigator
- Principal Investigator
  
  佐久間一郎
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hokkaido University
A RESERACH ON DEVELOPMENT AND APPLICATION OF THE CLINICALLY APPRICABLE NEW ARTIFICIALRED BLOOD CELLAND ARTIFICIAL OXYGEN CARRIERPrincipal Investigator
- Principal Investigator
  
  SAKUMA Ichiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  HOKKAIDO UNIVERSITY
A study forthe effects of estrogen on actions ofendothelium-derived hyperpolarizing factorPrincipal Investigator
- Principal Investigator
  
  SAKUMA Ichiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  HOKKAIDO UNIVERSITY
A study on the development and application of clinically available new artificial bloods and artificial oxygen carriersPrincipal Investigator
- Principal Investigator
  
  SAKUMA Ichiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  HOKKAIDO UNIVERSITY
A study on the application of hemoglobin derivatives that possess nitric oxide releasing capacity as artificial red cells
- Principal Investigator
  
  KITABATAKE Akira
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  HOKKAIDO UNIVERSITY
ホルモン補充療法が本邦女性の疾病構造に与える影響及び医療経済学的効果に関する研究Principal Investigator
- Principal Investigator
  
  佐久間一郎
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Public health/Health science
- Research Institution
  Hokkaido University
Investigation of Regression of Atherosclerotic Lesion through Regulation of Nitric Oxide Related Responses -Treatment by Gene Transfer of Nitric Oxide Synthase-
- Principal Investigator
  
  IGUCHI Akihisa
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
Development of modified hemoglobin molecules with regulated nitric oxide quenching action and their application for cardiovascular systemPrincipal Investigator
- Principal Investigator
  
  SAKURA Ichiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  HOKKAIDO UNIVERSITY
REDUCTION OF DIABETIC CARDIOVASCULAROPATHY BY AMINOGUANIDINEPrincipal Investigator
- Principal Investigator
  
  SAKUMA Ichiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  HOKKAIDO UNIVERSITY

All 2004 2003 2000

All Journal Article Book Patent

[Book] ヘモグロビン修飾型人工血液とパーフルオロケミカル. 周術期輸液の最前線2004
- Author(s)
  佐久間一郎
- Total Pages
  307
- Publisher
  真興交易(株)医書出版部
- Data Source
  KAKENHI-PROJECT-14370479
[Book] ヘモグロビン修飾型人工血液とパーフルオロケミカル.周術期輸液の最前線2004
- Author(s)
  佐久間一郎
- Total Pages
  307
- Publisher
  真興交易(株)医書出版部
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370479
[Journal Article] Characterization of regional cerebral blood flow and expression of angiogenic growth factors in the frontal cortex of juvenile male SHRSP and SHR.2004
- Author(s)
  Jesmin S, Togashi H, Mowa CN, Ueno K-I, Yamaguchi Y, Shibayama A, Miyauchi T, Sakuma I, Yoshioka M.
- Journal Title
  
  Brain Research 1030(2)
  
  Pages: 172-182
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390345
[Journal Article] Aromatase is abundantly expressed by neonatal rat penis but downregulated in adulthood.2004
- Author(s)
  Jesmin S, Mowa CH, Sakuma I, Matsuda N, Togashi H, Yoshioka M, Hattori Y, Kitabatake A
- Journal Title
  
  Journal of Molecular Endocrinology 33(2)
  
  Pages: 343-359
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390345
[Journal Article] Brain Expression of VEGF and its Receptors in SHR-SP and Effects of an Endothelin Blocker.2004
- Author(s)
  Jesmin S, Sakuma I, Togashi H, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T.
- Journal Title
  
  Journal Cardiovascular Pharmacology 44(Suppl.1)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390345
[Journal Article] Gonadal hormones and frontocortical expression of vascular endothelial growth factor in male stroke-prone, spontaneously hypertensive rats, a model for attention-deficit/ hyperactivity disorder.2004
- Author(s)
  Jesmin S, Togashi H, Sakuma I, Mowa CN, Ueno K-I, Yamaguchi T, Yoshioka M, Kitabatake A
- Journal Title
  
  Endocrinology 145(9)
  
  Pages: 4330-4343
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390345
[Journal Article] Expression of Endothelin Receptors in the Brainb of SHR-SP and Effects of an Endothelin Blocker.2004
- Author(s)
  Jesmin S, Sakuma I, Togashi H, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T.
- Journal Title
  
  Journal Cardiovascular Pharmacology 44(Suppl.1)
- Data Source
  KAKENHI-PROJECT-15390345
[Journal Article] Aromatase is abundantly expressed by neonatal rat penis but downregulated in adulthood2004
- Author(s)
  Jesmin S, Mowa CH, Sakuma I, Matsuda N, Togashi H, Yoshioka M, Hattori Y., Kitabatake A
- Journal Title
  
  Journal of Molecular Endocrinology 33(2)
  
  Pages: 343-359
- Data Source
  KAKENHI-PROJECT-15390345
[Journal Article] Expression of Endothelin Receptors in the Brain of SHR-SP and Effects of an Endothelin Blocker.2004
- Author(s)
  Jesmin S, Sakuma I, Togashi H, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T.
- Journal Title
  
  Journal Cardiovascular Pharmacology 44(Suppl.1)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390345
[Journal Article] Gonadal hormones and frontocortical expression of vascular endothelial growth factor in male stroke-prone, spontaneously hypertensive rats, a model for attention-deficit/hyperactivity disorder.2004
- Author(s)
  Jesmin S, Togashi H, Sakuma I, Mowa CN, Ueno K-I, Yamaguchi T, Yoshioka M, Kitabatake A
- Journal Title
  
  Endocrinology 145(9)
  
  Pages: 4330-4343
- Data Source
  KAKENHI-PROJECT-15390345
[Journal Article] Hemoglobin-based artificial blood and perfluorochemical.2004
- Author(s)
  Sakuma I
- Journal Title
  
  In Frontier of perioperative fluid infusion
  
  Pages: 169-176
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370479
[Journal Article] NO and pathogenesis. Artificial red blood Cell.2003
- Author(s)
  Sakuma I, Kitabatake A
- Journal Title
  
  Igaku no Ayumi 204(9)
  
  Pages: 631-635
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370479
[Journal Article] NOと病態.人工赤血球2003
- Author(s)
  佐久間一郎, 北畠顕
- Journal Title
  
  医学のあゆみ 204(9)
  
  Pages: 631-635
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370479
[Patent] 一酸化窒素代謝物-ポリオキシアルキレン-ヘモグロビン結合体2000
- Inventor(s)
  北畠顕, 佐久間一郎, 安河内徹, 仲井邦彦
- Industrial Property Rights Holder
  北海道大学, 日本油脂
- Filing Date
  2000-02-06
- Acquisition Date
  2003-12-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370479
[Patent] 一酸化窒素代謝物-ポリオキシアルキレン-ヘモグロビン結合体2000
- Inventor(s)
  北畠顕, 佐久間一郎, 安河内徹, 仲井邦彦
- Industrial Property Rights Holder
  北海道大学, 日本油脂
- Filing Date
  2000-02-08
- Acquisition Date
  2004-09-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370479

1. YOSHIOKA Mitsuhiro (40182729)

# of Collaborated Projects: 6 results

# of Collaborated Products: 8 results
2. TOGASHI Hiroko (20113590)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. NAKAI Kunihiko (00291336)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. FUJII Satoshi (90291228)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. FUKUSHIMA Shohji (80248103)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. FUJIMOTO Seiichiro (60001898)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. IGUCHI Akihisa (20109763)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. HAYASHI Toshio (80303634)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KITABATAKE Akira (00124769)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 服部裕一 (50156361)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. WATANABE Yasuo (10273228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FUKAO Mitsuhiro (10250432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TOHSE Noritsugu (80192657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MAKITA Naomasa (00312356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SUZUKI Yoshikatsu (30254288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KOZAKI Kouiti (80272540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 大塚吉則 (70233187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 岸玲子 (80112449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 松田ひとみ (80173847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 成田寛志 (30228093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 藤野敬史 (20209076)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 富樫広子

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results

SAKUMA Ichiro 佐久間 一郎

Research Projects

Research Products

Co-Researchers

A Study on Mechanisms of Regional Differences of Side Effects of Hormone Replacement Treatment (HRT)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脳毛細血管構築制御に関わるエストロゲン受容体サブタイプの遺伝子改変動物による解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathophysiological roles of Neurosteroids in an animal model of attention-deficit/hyperacivity disorder

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エストロゲンによる心臓および脳毛細血管網構築の制御とその生理的役割に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A RESERACH ON DEVELOPMENT AND APPLICATION OF THE CLINICALLY APPRICABLE NEW ARTIFICIALRED BLOOD CELLAND ARTIFICIAL OXYGEN CARRIERPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study forthe effects of estrogen on actions ofendothelium-derived hyperpolarizing factorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the development and application of clinically available new artificial bloods and artificial oxygen carriersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the application of hemoglobin derivatives that possess nitric oxide releasing capacity as artificial red cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ホルモン補充療法が本邦女性の疾病構造に与える影響及び医療経済学的効果に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of Regression of Atherosclerotic Lesion through Regulation of Nitric Oxide Related Responses -Treatment by Gene Transfer of Nitric Oxide Synthase-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of modified hemoglobin molecules with regulated nitric oxide quenching action and their application for cardiovascular systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

REDUCTION OF DIABETIC CARDIOVASCULAROPATHY BY AMINOGUANIDINEPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ヘモグロビン修飾型人工血液とパーフルオロケミカル. 周術期輸液の最前線2004

Author(s)

Total Pages

Publisher

SAKUMA Ichiro 佐久間一郎