SHIMIZU Toshihiko 清水利彦

… Alternative Names

Researcher Number	40265799
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2018: 慶應義塾大学, 医学部(信濃町), 講師 2007 – 2015: Keio University, 医学部, 講師 1995 – 1998: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Neurology / Pain science / Neurology Except Principal Investigator Neurology / Pain science
Keywords	Principal Investigator 片頭痛 / TRPV1 / 血小板 / 三叉神経 / CGRP / セロトニンレセプター / 遺伝子解析 / セロトニンレセプター / サブスタンP / サブスタンスP受容体 … More Except Principal Investigator 片頭痛 / 皮質拡延性抑制 / HMGB1 / 三叉神経節 / アポトーシス / 大脳皮質性拡延性抑制 / 三叉神経血管系 / TRPV1受容体 / ERK / ミトコンドリア / 三叉神経節ニューロン / オートファジー / ミトファジー / TRPV1 / カプサイシン / 神経修復機構 / リソソーム / アナンダマイド / 神経障害性疼痛 / ミクログリア / Toll-like receptor / 侵害性刺激 Less

慢性疼痛が皮質拡延性に及ぼす影響－片頭痛の病態解析Principal Investigator
- Principal Investigator
  
  清水利彦
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Keio University
Analysis of pain disease model-associated mitochondrial abnormalities in primary sensory neurons
- Principal Investigator
  
  Shibata Mamoru
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Keio University
Trigeminal contribution to the neurogenic inflammation in the dura materPrincipal Investigator
- Principal Investigator
  
  Shimizu Toshihiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Keio University
Research on migraine pathophysiology related to cortical spreading depression
- Principal Investigator
  
  SUZUKI Norihiro
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Keio University
The role of ASIC for pathophysiology of migrainePrincipal Investigator
- Principal Investigator
  
  SHIMIZU Toshihiko
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Keio University
片頭痛におけるサブスタンスP受容体の関与Principal Investigator
- Principal Investigator
  
  清水利彦
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Keio University
片頭痛患者におけるセロトニンレセプターの遺伝子解析Principal Investigator
- Principal Investigator
  
  清水利彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Keio University
片頭痛患者における自律神経機能の検討-主に血管反応性の変化について-Principal Investigator
- Principal Investigator
  
  清水利彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Keio University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] 頭痛，内科学2012
- Author(s)
  清水利彦
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-22390182
[Book] 脳神経外科学　改訂11版　4章頭痛2012
- Author(s)
  清水利彦
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-22390182
[Book] 緊急時の神経症候とその対処法　１．頭痛，神経疾患最新の治療2012-20142012
- Author(s)
  清水利彦
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-22390182
[Book] 片頭痛．日本薬理学会　編集　実践治療薬2012
- Author(s)
  清水利彦
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-22390182
[Book] 片頭痛の分類,臨床症状,診断,薬物療法,非薬物療法.アクチュアル脳・神経疾患の臨床.識る診る治す頭痛のすべて(鈴木則宏編集)2011
- Author(s)
  清水利彦
- Publisher
  中山書店,東京
- Data Source
  KAKENHI-PROJECT-22390182
[Book] 閃輝暗点はなぜ中心から周辺に移動するのか、なぜ片頭痛がおこるのか?眼のサイエンス,眼疾患の謎(根木昭、田野保雄、坪田一男、大鹿哲郎編)2010
- Author(s)
  清水利彦、鈴木則宏
- Publisher
  文光堂、東京
- Data Source
  KAKENHI-PROJECT-22390182
[Book] これでわかる頭痛診療-頭痛外来でのノウハウとコツ2010
- Author(s)
  鈴木則宏、清水利彦、柴田護
- Publisher
  南江堂、東京
- Data Source
  KAKENHI-PROJECT-22390182
[Book] Biological sciences related to headache. In the Handbook of Clinical Neurology Vol.97 Headache(ed by Michael J.Aminoff, Francois Boller, Dick F.Swaab)2010
- Author(s)
  Shimizu T, Suzuki N
- Publisher
  Elsevier Amsterdam
- Data Source
  KAKENHI-PROJECT-22390182
[Book] 6.片頭痛は脳梗塞のリスクですか?棚橋紀夫, 北川泰久(編).脳卒碗診療こんなときどうするQ&A2008
- Author(s)
  清水利彦
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19591005
[Journal Article] Functional interactions between transient receptor potential M8 and transient receptor potential V1 in the trigeminal system: Relevance to migraine pathophysiology.2018
- Author(s)
  Kayama Y, Shibata M, Takizawa T, Ibata K, Shimizu T, Ebine T, Toriumi H, Yuzaki M, Suzuki N.
- Journal Title
  
  Cephalalgia
  
  Volume: 38(5) Pages: 833-845
- DOI
  10.1177/0333102417712719
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06461, KAKENHI-PROJECT-26460706, KAKENHI-PROJECT-15H05772
[Journal Article] Signaling Pathways Relevant to Nerve Growth Factor-induced Upregulation of Transient Receptor Potential M8 Expression.2017
- Author(s)
  Kayama Y, Shibata M, Takizawa T, Ibata K, Nakahara J, Shimizu T, Toriumi H, Yuzaki M, Suzuki N.
- Journal Title
  
  Neuroscience
  
  Volume: 367 Pages: 178-188
- DOI
  10.1016/j.neuroscience.2017.10.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460706
[Journal Article] High-mobility group box 1 (HMGB1) is an important mediator of microglial activation induced by cortical spreading depression.2017
- Author(s)
  Takizawa T., Shibata M., Kayama Y., Shimizu T., Toriumi H., Ebine T., Unekawa M., Koh A., Yoshimura A., Suzuki N.
- Journal Title
  
  J Cereb Blood Flow Metab
  
  Volume: 37 Pages: 890-901
- DOI
  10.1177/0271678x16647398
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26350981, KAKENHI-PROJECT-26460706
[Journal Article] Repetitive trigeminal nociceptive stimulation in rats increases their susceptibility to cortical spreading depression.2016
- Author(s)
  Toriumi H, Shimizu T, Ebine T, Takizawa T, Kayama Y, Koh A, Shibata M, Suzuki N
- Journal Title
  
  Neurosci Res
  
  Volume: 106 Pages: 74-78
- DOI
  10.1016/j.neures.2015.12.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460726
[Journal Article] Temporal profiles of high-mobility group box 1 expression levels after cortical spreading depression in mice.2016
- Author(s)
  Takizawa T, Shibata M, Kayama Y, Toriumi H, Ebine T, Koh A, Shimizu T, Suzuki N
- Journal Title
  
  Ｃｅｐｈａｌａｌｇｉａ
  
  Volume: 印刷中 Pages: 44-52
- DOI
  10.1177/0333102415580100
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22390182, KAKENHI-PROJECT-25460726, KAKENHI-PROJECT-26460706
[Journal Article] Alterations in the threshold of the potassium concentration to evoke cortical spreading depression during the natural estrous cycle in mice.2016
- Author(s)
  Taeko Ebine, Haruki Toriumi, Toshihiko Shimizu, Miyuki Unekawa, Tsubasa Takizawa, Yohei Kayama, Mamoru Shibata, Norihiro Suzuki
- Journal Title
  
  Neurosci. Res.
  
  Volume: 112 Pages: 57-62
- DOI
  10.1016/j.neures.2016.06.001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08996, KAKENHI-PROJECT-26350981
[Journal Article] Adult-onset recurrent painful ophthalmoplegic neuropathy displaying atypical oculomotor nerve gadolinium-enhancement pattern in the orbit and cavernous sinus.2016
- Author(s)
  Takizawa T, Shibata M*, Fujiwara H, Shimizu T, Momoshima S, Suzuki N.
- Journal Title
  
  Cephalalgia
  
  Volume: 36 Pages: 199-200
- DOI
  10.1177/0333102415583987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460706
[Journal Article] Temporal profiles of high-mobility group box 1 expression levels after cortical spreading depression in mice.2015
- Author(s)
  Takizawa T, Shibata M, Kayama Y, Toriumi H, Ebine T, Koh A, Shimizu T, Suzuki.
- Journal Title
  
  Cephalalgia
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460706
[Journal Article] 国際頭痛分類改訂版βのポイント2014
- Author(s)
  清水利彦
- Journal Title
  
  日本頭痛学会誌
  
  Volume: 41 Pages: 21-25
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] 片頭痛を分類する．2014
- Author(s)
  清水利彦
- Journal Title
  
  日本頭痛学会誌
  
  Volume: 41 Pages: 121-125
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] 群発頭痛の治療に関する最近の進歩2013
- Author(s)
  清水利彦
- Journal Title
  
  臨床神経学
  
  Volume: 53 Pages: 1131-1133
- NAID
  130004505360
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] Activation of extracellular signal-regulated kinase in the trigeminal ganglion following both treatment of the dura mater with capsaicin and cortical spreading depression.2013
- Author(s)
  Iwashita T, Shimizu T, Shibata M, Toriumi H, Ebine T, Funakubo M, Suzuki N.
- Journal Title
  
  Neurosci Res.
  
  Volume: 77 Pages: 110-119
- DOI
  10.1016/j.neures.2013.08.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390182, KAKENHI-PROJECT-24590732
[Journal Article] Differential cellular localization of antioxidant enzymes in the trigeminal ganglion.2013
- Author(s)
  Sato H, Shibata M, Shimizu T, Shibata S, Haruki T, Ebine T, Kuroi T, Iwashita T, Funakubo M, Kayama Y, Akazawa C, Wajima K, Nakagawa T. Okano H. Suzuki N
- Journal Title
  
  Neuroscience.
  
  Volume: 248 Pages: 345-348
- DOI
  10.1016/j.neuroscience.2013.06.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00978, KAKENHI-PROJECT-22390182, KAKENHI-PROJECT-24500447, KAKENHI-PROJECT-24590732
[Journal Article] 片頭痛の病態生理2012
- Author(s)
  清水利彦
- Journal Title
  
  神経内科
  
  Volume: 77 Pages: 331-336
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] 片頭痛病態研究の展開と新たな治療への展望2012
- Author(s)
  清水利彦, 鈴木則宏
- Journal Title
  
  Brain and Nerve
  
  Volume: 64 Pages: 59-64
- NAID
  40019143190
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] Reduction of TRPV1 expression in the trigeminal system by botulinum neurotoxin type-A.2012
- Author(s)
  Shimizu T
- Journal Title
  
  Neurobiol Dis.
  
  Volume: 48 Pages: 367-378
- DOI
  10.1016/j.nbd.2012.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390182, KAKENHI-PROJECT-24590732
[Journal Article] Developmental and circulatory profile of the diploic veins2011
- Author(s)
  Toriumi H, Shimizu T, et al
- Journal Title
  
  Microvascular Research
  
  Volume: 81 Pages: 97-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591005
[Journal Article] 片頭痛における慢性化のメカニズム2011
- Author(s)
  清水利彦
- Journal Title
  
  日本頭痛学会誌
  
  Volume: 38 Pages: 56-58
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] 片頭痛の病態研究および治療に関する最近の知見2011
- Author(s)
  清水利彦、柴田護、鈴木則宏
- Journal Title
  
  臨床神経
  
  Volume: 51 Pages: 103-109
- NAID
  10031163984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] Developmental and circulatory profile of the diploic veins2011
- Author(s)
  Toriumi H, Shimizu T, Shibata M, Unekawa M, Tomita Y, Tomita M, Suzuki N
- Journal Title
  
  Microvascular Res. Vol 81
  
  Pages: 97-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591005
[Journal Article] 片頭痛の病態研究および治療に関する最近の知見2011
- Author(s)
  清水利彦,柴田護,鈴木則宏
- Journal Title
  
  臨床神経学 51巻
  
  Pages: 103-109
- NAID
  10031163984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591005
[Journal Article] 外来での頭痛のみかた-危ない頭痛の鑑別2011
- Author(s)
  小泉健三, 清水利彦, 鈴木則宏
- Journal Title
  
  診断と治療
  
  Volume: 99 Pages: 1237-1241
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] 頭痛.症状からアプローチするプライマリケア2011
- Author(s)
  小泉健三, 清水利彦, 鈴木則宏
- Journal Title
  
  日本医師会雑誌
  
  Volume: 140
- NAID
  40019021150
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] TRPV1発現量に応じたカプサイシン刺激時の細胞死誘導機構片頭痛慢性化への関与2011
- Author(s)
  舟久保恵美, 柴田護, 清水利彦, 岩下達雄, 鳥海春樹, 鈴木則宏
- Journal Title
  
  日本頭痛学会誌
  
  Volume: 38 Pages: 21-24
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] Developmental and circulatory profile of the diploic veins2011
- Author(s)
  Toriumi H, Shimizu T, Shibata M, Unekawa M, Tomita Y, Tomita M, Suzuki N
- Journal Title
  
  Microvascular Research
  
  Volume: 81 Pages: 97-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] 小児の片頭痛は大人の片頭痛と同じ病態ですか?2010
- Author(s)
  清水利彦
- Journal Title
  
  Clinical Neuroscience.
  
  Volume: 28 Pages: 1195-1195
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] 片頭痛の病態2010
- Author(s)
  清水利彦
- Journal Title
  
  神経内科
  
  Volume: 72 Pages: 127-132
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] 光刺激による片頭痛増悪のメカニズムについて2010
- Author(s)
  清水利彦
- Journal Title
  
  Headache Clinical & Science
  
  Volume: 1 Pages: 12-13
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] 頭痛の分類と診断・治療2010
- Author(s)
  清水利彦, 鈴木則宏
- Journal Title
  
  からだの科学
  
  Volume: 265 Pages: 200-203
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] 頭痛の原因と診断2010
- Author(s)
  小泉健三、清水利彦、鈴木則宏
- Journal Title
  
  臨床と研究
  
  Volume: 1027 Pages: 1021-1026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] TRPV1受容体と片頭痛2010
- Author(s)
  清水利彦
- Journal Title
  
  日本頭痛学会誌
  
  Volume: 37 Pages: 32-34
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] 新しい頭痛疾患.めまいと頭痛:その原因と治療法2010
- Author(s)
  清水利彦、鈴木則宏
- Journal Title
  
  レジデント
  
  Volume: 3 Pages: 82-86
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] 頭痛.初診外来における初期治療2010
- Author(s)
  岩下達彦、清水利彦、鈴木則宏
- Journal Title
  
  診断と治療増刊号
  
  Volume: 98 Suppl Pages: 2-9
- Data Source
  KAKENHI-PROJECT-22390182
[Journal Article] 頭痛片頭痛を中心に.2008
- Author(s)
  清水利彦
- Journal Title
  
  実験治療 691
  
  Pages: 124-128
- Data Source
  KAKENHI-PROJECT-19591005
[Journal Article] 神経原性炎症のメカニズム研究.2008
- Author(s)
  清水利彦
- Journal Title
  
  カレントテラピー 26
  
  Pages: 887-890
- Data Source
  KAKENHI-PROJECT-19591005
[Journal Article] 片頭痛の最新のトピックス-薬物治療の問題点と今後望まれる薬剤2008
- Author(s)
  清水利彦
- Journal Title
  
  日薬理誌 131
  
  Pages: 210-214
- NAID
  10024382193
- Data Source
  KAKENHI-PROJECT-19591005
[Journal Article] Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat.2007
- Author(s)
  Shimizu T
- Journal Title
  
  Brain Res 1173
  
  Pages: 84-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591005
[Journal Article] Distribution and origin of TRPV1 receptor-containing nerve ffibers in the dura mater of rat2007
- Author(s)
  Shimizu T
- Journal Title
  
  Brain Res 1173
  
  Pages: 84-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591005
[Journal Article] Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat2007
- Author(s)
  Shimizu T, Toriumi H, Sato H, Shibata M, Nagata E, Gotoh K, Suzuki N
- Journal Title
  
  Brain Res. Vol.1173
  
  Pages: 84-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591005
[Journal Article] 片頭痛の発症メカニズム説2007
- Author(s)
  清水利彦
- Journal Title
  
  薬局 58
  
  Pages: 2175-2178
- Data Source
  KAKENHI-PROJECT-19591005
[Presentation] Development of photophobia-like behaviors after cortical spreading depression in mice2018
- Author(s)
  Kitagawa S,Shibata M, Unekawa M, Kayama Y, Hua TC , Shimizu T,Suzuki N, Nakahara J
- Organizer
  第46回日本頭痛学会総会
- Data Source
  KAKENHI-PROJECT-16K08996
[Presentation] TRPV1（シンポジウム3「頭痛の病態に関わるホットな分子たち」）2017
- Author(s)
  清水利彦
- Organizer
  第45回日本頭痛学会総会
- Data Source
  KAKENHI-PROJECT-16K08996
[Presentation] Facial TRPM8 stimulation ameliorates thermal hyperalgesia in a mouse migraine model.2017
- Author(s)
  Kayama S, Shibata M, Takizawa T, Shimizu T, Toriumi H, Ebine T, Suzuki N.
- Organizer
  IHC2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460706
[Presentation] Cortical spreading depression alters the progranulin expression in cortical neurons.2017
- Author(s)
  Kitagawa S, Takizawa T, Kayama Y, Toriumi H, Shimizu T, Shibata M, Suzuki N.
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460706
[Presentation] Temporal profiles of TRPM8 and TRPV1 expression in the trigeminal ganglion neurons after CFA-induced inflammation.2016
- Author(s)
  Kayama Y, Shibata M, Takizawa T, Shimizu T, Toriumi H, Ebine T, Suzuki N.
- Organizer
  EHMTIC2016
- Place of Presentation
  Glasgow (Scotland)
- Year and Date
  2016-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460706
[Presentation] Distribution of the calcitonin gene-related peptide receptors in the sphenopalatine ganglion of rat.2015
- Author(s)
  Koh A, Shimizu T, Shibata M, Takizawa T, Kayama Y, Ebine T, Toriumi H, Suzuki N
- Organizer
  17th Congress of the International Headache Society 2015 (IHC2015)
- Place of Presentation
  Valencia, Spain
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460726
[Presentation] Microglial activation by multiple inductions of cortical spreading depression.2015
- Author(s)
  Takizawa T, Shibata M, Kayama Y, Shimizu T, Toriumi H, Ebine T, Koh A, Suzuki N.
- Organizer
  Congress of the International Headache Society 2015 (IHC2015)
- Place of Presentation
  Valencia, Spain
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460726
[Presentation] Microglial activation by multiple inductions of cortical spreading depression.2015
- Author(s)
  Takizawa T, Shibata M, Kayama Y, Shimizu T, Toriumi H, Ebine T, Koh A, Suzuki N.
- Organizer
  17th Congress of the International Headache Society 2015
- Place of Presentation
  Valencia, Spain
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460726
[Presentation] Differential cellular localization of antioxidant enzymes in the trigeminal ganglion.2014
- Author(s)
  Shibata M, Sato H, Shimizu T, Shibata S, Toriumi H, Ebine T, Kuroi T, Iwashita T, Funakubo M, Kayama Y, Akazawa C, Wajima K, Nakagawa T, Okano H, Suzuki N.
- Organizer
  Pan-Asian/Pan-American Program, American Headache Society 2014, June 2014, Los Angeles.
- Place of Presentation
  Hyatt Regency Century Plaza, Los Angeles, USA
- Year and Date
  2014-06-26
- Invited
- Data Source
  KAKENHI-PROJECT-26460706
[Presentation] 国際頭痛分類改訂版βのポイント．2013
- Author(s)
  清水利彦
- Organizer
  第41回日本頭痛学会
- Place of Presentation
  岩手県盛岡市
- Invited
- Data Source
  KAKENHI-PROJECT-25460726
[Presentation] 脳硬膜の神経原性炎症における三叉神経侵害刺激の関与について．2013
- Author(s)
  海老根妙子、鳥海春樹、滝沢翼、萱間洋平、黄杏里、柴田　護、清水利彦、鈴木則宏
- Organizer
  第41回日本頭痛学会
- Place of Presentation
  岩手県盛岡市
- Data Source
  KAKENHI-PROJECT-25460726
[Presentation] The effects of Botulinum toxin type A on the trigeminal TRPV1 containing neurons innervating the dura mater of rat.2012
- Author(s)
  Shimizu T
- Organizer
  European Headache and Migraine Trust International Congress 2012
- Place of Presentation
  英国，ロンドン
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] The effect of botulinum neurotoxin type A on TRPV1 expression in the trigeminal system2012
- Author(s)
  Shimizu T
- Organizer
  The 4th Asian Regional Conference for Headache 2012
- Place of Presentation
  台湾・台北
- Invited
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] TRPV1 expression in the trigeminal system is decreased by botulinum neurotoxin type-A2012
- Author(s)
  Shimizu T
- Organizer
  54th Annual Scientific Meeting of American Headache Society Americans and Asian Pacific Joint Symposium
- Place of Presentation
  米国，ロサンゼルス
- Invited
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] 三叉神経系の活性化によるCortical Spreading Depressionへの影響2011
- Author(s)
  小泉健三、畝川美悠紀、鳥海春樹、柴田護、清水利彦、黒井俊哉、佐藤仁、舟久保恵美, 岩下達雄, 鈴木則宏
- Organizer
  第39回日本頭痛学会総会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] 三叉神経系の活性化によるCortical Spreading Depressionへの影響.2011年11月埼玉.日本頭痛学会誌38:227,20112011
- Author(s)
  鳥海春樹、海老根妙子、黒井俊哉、佐藤仁, 舟久保恵美、岩下達雄、小泉健三、柴田護、清水利彦、鈴木則宏
- Organizer
  第39回日本頭痛学会総会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] A型ボツリヌス毒素は三叉神経節ニューロンのTRPV1細胞膜発現を低下させる-抗片頭痛薬効機序との関連2011
- Author(s)
  柴田護、清水利彦、岩下達雄、鳥海春樹、舟久保恵美、小泉健三、佐藤仁、黒井俊哉、鈴木則宏
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] Botulinum neurotoxin type A reduces TRPV1 expression in trigeminal ganglion neurons by inhibiting TRPV1 plasma membrane trafficking2011
- Author(s)
  Shibata M, Shimizu T, Iwashita T, Toriumi H, Funakubo M, Koizumi K, Sato H, Kuroi T, Suzuki N
- Organizer
  15^<th> Congress of the International Headache Society
- Place of Presentation
  ベルリン,ドイツ
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] The effect of acute trigeminal activation on CSD threshold2011
- Author(s)
  Toriumi H, Kuroi T, Sato H, Funakubo M, Iwashita T, Koizumi K, Shibata M, Shimizu T, Suzuki N
- Organizer
  15^<th> Congress of the International Headache Society
- Place of Presentation
  ベルリン,ドイツ
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] 三叉神経領域におけるA型ボツリヌス毒素投与によるラット疼痛行動抑制効果について2011
- Author(s)
  舟久保恵美, 柴田護, 清水利彦, 岩下達雄, 鳥海春樹, 海老根妙子, 佐藤仁, 黒井俊哉, 小泉健三, 鈴木則宏
- Organizer
  第39回日本頭痛学会総会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] Excess TRPV1 stimulation leads to the induction of autophagy2010
- Author(s)
  Shibata M, Shimizu T, Funakubo M, Iwashita T, Toriumi H, Koizumi K, Itoh Y, Suzuki N
- Organizer
  Neuroscience Meeting 2010
- Place of Presentation
  San Diego
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] 脳神経系の自律神経節におけるRAMP-1の分布-片頭痛の病態への関与の可能性ついて2010
- Author(s)
  小泉健三, 清水利彦, 柴田護, 鳥海春樹, 岩下達雄, 舟久保恵美, 鈴木則宏
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] エタノールによるTRPV1を介したカスパーゼ-8活性化-片頭痛病態への関与(日本頭痛学会誌37:191,2010)2010
- Author(s)
  舟久保恵美, 柴田護, 清水利彦, 岩下達雄, 鳥海春樹, 佐藤仁, 黒井俊哉, 小泉健三, 鈴木則宏
- Organizer
  第38回日本頭痛学会総会
- Place of Presentation
  東京
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] TRPV1による侵害受容で引き起こされる細胞死の誘導機構-片頭痛病態との関連性2010
- Author(s)
  柴田護、舟久保恵美、清水利彦、岩下達雄、鳥海春樹、鈴木則宏
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] 大規模疫学調査による大学病院職員における頭痛の実態2010
- Author(s)
  鈴木則宏、石川良樹、五味慎太郎、伊東信彦、三宅仁、渡邉茂、横山雅子、清水利彦、柴田護
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] 慢性片頭痛病態モデルを用いたラット三叉神経尾側核の免疫組織化学染色検討(日本頭痛学会誌37:192,2010)2010
- Author(s)
  黒井俊哉, 鳥海春樹, 佐藤仁, 舟久保恵美, 岩下達雄, 小泉健三, 柴田護, 清水利彦, 鈴木則宏
- Organizer
  第38回日本頭痛学会総会
- Place of Presentation
  東京
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] RPV1高発現時のカプサイシン刺激による細胞死誘導機構-片頭痛病態への関与2010
- Author(s)
  舟久保恵美, 柴田護, 清水利彦, 岩下達雄, 鳥海春樹, 小泉健三, 鈴木則宏
- Organizer
  第32回日本疼痛学会
- Place of Presentation
  京都
- Year and Date
  2010-07-03
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] 片頭痛における慢性化のメカニズム2010
- Author(s)
  清水利彦
- Organizer
  第38回日本頭痛学会総会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-19591005
[Presentation] 閉経後の片頭痛患者の特徴に関する実態調査.(日本頭痛学会誌37:238,2010)2010
- Author(s)
  牧田和也, 平沢晃, 柴田護, 清水利彦, 青木大輔, 鈴木則宏
- Organizer
  第38回日本頭痛学会総会
- Place of Presentation
  東京
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] A型ボツリヌス毒素の片頭痛予防効果に関する研究-TRPV1受容体の関与2010
- Author(s)
  清水利彦, 柴田護, 鳥海春樹, 岩下達雄, 舟久保恵美, 小泉健三, 鈴木則宏
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] 脳硬膜侵害刺激による三叉神経節神経細胞におけるERKリン酸化の経時変化2010
- Author(s)
  岩下達雄, 清水利彦, 柴田護, 鳥海春樹, 舟久保恵美, 鈴木則宏
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] 脳硬膜侵害刺激による三叉神経節神経細胞におけるERKリン酸化の経時変化2010
- Author(s)
  岩下達雄,清水利彦
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-19591005
[Presentation] TRPV1高発現時のカプサイシン刺激によるカスパーゼ2の活性化.(日本頭痛学会誌37:194,2010)2010
- Author(s)
  佐藤仁, 柴田護, 清水利彦, 岩下達雄, 鳥海春樹, 小泉健三, 舟久保恵美, 黒井俊哉, 鈴木則宏
- Organizer
  第38回日本頭痛学会総会
- Place of Presentation
  東京
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] TRPV1受容体を介した三叉神経の侵害刺激がCSD発生に及ぼす影響.(日本頭痛学会誌37:193,2010)2010
- Author(s)
  鳥海春樹, 畝川美悠紀, 黒井俊哉, 佐藤仁、舟久保恵美, 岩下達雄, 小泉健三, 柴田護, 清水利彦, 鈴木則宏
- Organizer
  第38回日本頭痛学会総会
- Place of Presentation
  東京
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] A型ボツリヌス毒素の三叉神経節におけるTRPV1発現への影響-投与量による比較検討-2009
- Author(s)
  清水利彦
- Organizer
  第37回日本頭痛学会総会
- Place of Presentation
  宇都宮
- Year and Date
  2009-11-29
- Data Source
  KAKENHI-PROJECT-19591005
[Presentation] A型ボツリヌス毒素の三叉神経節におけるTRPV1 発現への影響-投与量による比較検討-2009
- Author(s)
  清水利彦
- Organizer
  第37回日本頭痛学会総会
- Place of Presentation
  宇都宮
- Year and Date
  2009-11-29
- Data Source
  KAKENHI-PROJECT-19591005
[Presentation] The effect of Botulinum toxin type A on the TRPV1 receptor in the trige minal ganglion of the rat.2008
- Author(s)
  Shimizu T
- Organizer
  European Hea dache and Migraine Trust International Congress
- Place of Presentation
  London, UK
- Year and Date
  2008-09-07
- Data Source
  KAKENHI-PROJECT-19591005
[Presentation] The effect of Botulinum toxin type A on the TRPVl receptor in the trigeminal ganglion of the rat.2008
- Author(s)
  Shimizu T
- Organizer
  European Headache and Migraine Trust International Congress
- Place of Presentation
  London, UK
- Year and Date
  2008-09-07
- Data Source
  KAKENHI-PROJECT-19591005
[Presentation] The effect of Botulinum toxin type A on the TRPV1 receptor in the trigeminal ganglion of the rat2008
- Author(s)
  清水利彦
- Organizer
  European Headache and Migraine Trust International Congress
- Place of Presentation
  London, UK
- Year and Date
  2008-09-07
- Data Source
  KAKENHI-PROJECT-19591005
[Presentation] ラット脳硬膜におけるTRPV1陽性神経の起源につい2007
- Author(s)
  清水利彦
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-18
- Data Source
  KAKENHI-PROJECT-19591005
[Presentation] ラット脳硬膜におけるTRPV1陽性神経の起源について2007
- Author(s)
  清水利彦
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-18
- Data Source
  KAKENHI-PROJECT-19591005
[Presentation] Effect of nociceptive stimulaiton of the dura mater and cortical spreading depression on the phosphorylation of ERK in the trigeminal ganglion of rat.
- Author(s)
  Shimizu T
- Organizer
  The 5th Asian Regional Conference for Headache 2015
- Place of Presentation
  Chiang Mai, Thailand
- Year and Date
  2015-01-31 – 2015-02-01
- Invited
- Data Source
  KAKENHI-PROJECT-25460726
[Presentation] 脳硬膜および顔面に分布する感覚神経線維の三叉神経節における局在について
- Author(s)
  海老根妙子、鳥海春樹、滝沢翼、萱間洋平、黄杏里、柴田　護、清水利彦、鈴木則宏．
- Organizer
  日本頭痛学会
- Place of Presentation
  下関
- Year and Date
  2014-11-14 – 2014-11-15
- Data Source
  KAKENHI-PROJECT-25460726
[Presentation] Implication of TRPM8 in the TRPV1-mediated trigeminal nociception.
- Author(s)
  Kayama Y, Shibata M, Takizawa T, Shimizu T, Toriumi H, Ebine T, Funakubo M, Iwashita T, Sato H, Suzuki N.
- Organizer
  16th Congress of the International Headache Society 2013
- Place of Presentation
  米国，ボストン
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] 炎症性メディエーター存在下におけるTRPM８発現調節
- Author(s)
  萱間洋平、柴田　護、滝沢翼、清水利彦、鳥海春樹、海老根妙子、黄　杏里、鈴木則宏．
- Organizer
  日本頭痛学会
- Place of Presentation
  海峡メッセ下関（山口県下関市)
- Year and Date
  2014-11-14 – 2014-11-15
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] Effect of nociceptive stimulaiton of the dura mater and cortical spreading depression on the phosphorylation of ERK in the trigeminal ganglion of rat
- Author(s)
  Shimizu T
- Organizer
  The 5th Asian Regional Conference for Headache 2015
- Place of Presentation
  50th years anniversary building, Maharaj Nakorn Chiangmai Hospital, Chiangmai University　（Chiangmai、Thailand)
- Year and Date
  2015-01-31 – 2015-02-01
- Invited
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] 皮質性拡延性抑制後の大脳皮質におけるHMGB1発現誘導
- Author(s)
  滝沢　翼、柴田　護、萱間洋平、海老根妙子、佐藤　仁、黄杏里、鳥海春樹、清水利彦、鈴木則宏.
- Organizer
  第55回日本神経学会総会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] Capsaicin-induced nerve fiber degeneration in the spinal tract of the trigeminal nucleus.
- Author(s)
  Shibata M, Ebine T, Nagai T, Toriumi H, Shimizu T, Iwashita T, Funakubo M, Takizawa T, Kayama Y, Suzuki N.
- Organizer
  16th Congress of the International Headache Society 2013
- Place of Presentation
  米国，ボストン
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] Effect of cortical spreading depression on the phosphorylation of ERK in the trigeminal ganglion of rat.
- Author(s)
  Iwashita T, Shimizu T, Shibata M, Toriumi H, Kayama Y, Ebine T, Takizawa T, Funakubo M, Suzuki N.
- Organizer
  16th Congress of the International Headache Society 2013
- Place of Presentation
  米国，ボストン
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] 皮質拡延性抑制後の大脳皮質におけるHMGB1発現誘導．
- Author(s)
  滝沢　翼、柴田　護、萱間洋平、海老根妙子、清水利彦、鳥海春樹、黄　杏里、清水利彦、鈴木則宏．
- Organizer
  日本頭痛学会
- Place of Presentation
  海峡メッセ下関（山口県下関市)
- Year and Date
  2014-11-14 – 2014-11-15
- Data Source
  KAKENHI-PROJECT-22390182
[Presentation] Expression of high-mobility group box-1 in the cerebral cortex after cortical spreading depression.
- Author(s)
  Takizawa T, Shibata M, Kayama Y, Shimizu T, Toriumi H, Ebine T, Koh A, Suzuki N.
- Organizer
  European Headache and Migraine Trust International Congress 2014
- Place of Presentation
  Bella Center (Cophenhegen, Denmark)
- Year and Date
  2014-09-18 – 2014-09-21
- Data Source
  KAKENHI-PROJECT-22390182

1. SHIBATA Mamoru (60286466)

# of Collaborated Projects: 4 results

# of Collaborated Products: 49 results
2. TORIUMI Haruki (30528203)

# of Collaborated Projects: 2 results

# of Collaborated Products: 30 results
3. SUZUKI Norihiro (10158975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 43 results
4. KOIZUMI Kenzo (30439070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
5. FUNAKUBO Megumi (90548538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
6. EBINE Taeko

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 柚崎通介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 畝川美悠紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 芝田晋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 岡野栄之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMIZU Toshihiko 清水 利彦

清水 利彦 シミズ トシヒコ

Research Projects

Research Products

Co-Researchers

慢性疼痛が皮質拡延性に及ぼす影響－片頭痛の病態解析Principal Investigator

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Analysis of pain disease model-associated mitochondrial abnormalities in primary sensory neurons

Principal Investigator

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Trigeminal contribution to the neurogenic inflammation in the dura materPrincipal Investigator

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Research on migraine pathophysiology related to cortical spreading depression

Principal Investigator

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The role of ASIC for pathophysiology of migrainePrincipal Investigator

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片頭痛におけるサブスタンスP受容体の関与Principal Investigator

Principal Investigator

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片頭痛患者におけるセロトニンレセプターの遺伝子解析Principal Investigator

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片頭痛患者における自律神経機能の検討-主に血管反応性の変化について-Principal Investigator

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[Book] 頭痛，内科学2012

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[Book] 脳神経外科学 改訂11版 4章頭痛2012

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[Book] 緊急時の神経症候とその対処法 １．頭痛，神経疾患最新の治療2012-20142012

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[Book] 片頭痛．日本薬理学会 編集 実践治療薬2012

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[Book] 片頭痛の分類,臨床症状,診断,薬物療法,非薬物療法.アクチュアル脳・神経疾患の臨床.識る診る治す頭痛のすべて(鈴木則宏編集)2011

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[Book] 閃輝暗点はなぜ中心から周辺に移動するのか、なぜ片頭痛がおこるのか?眼のサイエンス,眼疾患の謎(根木昭、田野保雄、坪田一男、大鹿哲郎編)2010

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[Book] これでわかる頭痛診療-頭痛外来でのノウハウとコツ2010

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SHIMIZU Toshihiko 清水利彦

清水利彦シミズトシヒコ

[Book] 脳神経外科学　改訂11版　4章頭痛2012

[Book] 緊急時の神経症候とその対処法　１．頭痛，神経疾患最新の治療2012-20142012

[Book] 片頭痛．日本薬理学会　編集　実践治療薬2012