ICHINOSE Koji 市瀬浩志

… Alternative Names

市瀬浩志イチノセコウジ

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Researcher Number	40282610
Other IDs
External Links
Affiliation (Current)	2022: 武蔵野大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2022: 武蔵野大学, 薬学部, 教授 2005 – 2012: 武蔵野大学, 薬学研究所, 教授 1997 – 2003: 東京大学, 大学院・薬学系研究科, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / Living organism molecular science / Chemical pharmacy / Science and Engineering / 化学系薬学 / Basic Section 47050:Environmental and natural pharmaceutical resources-related Except Principal Investigator Science and Engineering / Natural medicines
Keywords	Principal Investigator 放線菌 / 抗生物質 / 生合成 / 生合成遺伝子 / ゲノムシークエンス / 天然有機化合物 / ポリケタイド / 酸素添加 / actinomycetes / ステロイドサポニン … More / クローニング / 単子葉植物 / 機能発現 / 配糖体 / ステロイドサポリン / cDNAクローニング / 立体化学制御 / フラビン酵 / フラビン酵素 / 酵素添加 / ゲノム / ポリケイタイド / 再構成 / デオキシ糖 / deoxysugar / antibiotics / biosynthetic genes / 酵素 / 酸化還元 / 糖 / antibiotic / biosynthesis / enzyme / oxido-reduction / ナフトキノン / 二次代謝 / 官能基化 / 二量化 / モデリング / 変異型酵素 / 機能解析 / フラビン / 酵素解析 / 生合成酵素 / 高度官能基化 / 基質認識 … More Except Principal Investigator ポリケタイド / 生合成 / 生合成酵素 / 生合成遺伝子 / 機能発現 / ポリケタイド合成酵素 / 糸状菌 / トリテルペン / トリテルペン合成酵素 / カルコン / スチルベン / オキシドスクワレン / サポニン / ポロケタイド / 酵素 / メラニン / 分生子 / ソラナピロン / Aspergillno fumigatuo / 合成酵素 / 色素 / biosynthetic enzyme / biosynthetic gene / functional expression / polyketide / polyketide synthase / filamentous fungi / triterpene / triterpene synthase / アクチノロジン / 酸素添加 / 水酸化 / エノイル還元 / テトラサイクリン耐性率 / テトラサイクリン / 酵素機能 / タンパク精製 / 放線菌 / 連続水酸化反応 / 抗生物質 / 薬剤耐性 Less

Generation of highly functionalized naphthoquiones based on the mechanistic understanding of biosynthetic enzymesPrincipal Investigator
- Principal Investigator
  
  市瀬浩志
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Musashino University
Biosynthetic studies of aromatic polyketides to overcome tetracyclin-resistance of Escherichia coli.
- Principal Investigator
  
  Taguchi Takaaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  National Institute of Health Sciences
アクノロジン生産完全再構成系による単機能反復型生合成反応の網羅的分子機構解明Principal Investigator
- Principal Investigator
  
  市瀬浩志
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  Musashino University
芳香族ポリケタイド生合成マシナリー再構築に向けた比較ゲノム機能解析Principal Investigator
- Principal Investigator
  
  市瀬浩志
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Musashino University
Functional analysis of the enzymes involved in the structural modification of polyketides and its application to the production of novel scaffoldsPrincipal Investigator
- Principal Investigator
  
  ICHINOSE Koji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Musashino University
Production of novel biologically active molecules based on the functional analysis of glycosylation enzymes related to secondary metabolismPrincipal Investigator
- Principal Investigator
  
  ICHINOSE Koji
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Musashino University
ゲノム研究基軸放線菌における抗生物質生合成鍵酵素の構造予測と機能解析Principal Investigator
- Principal Investigator
  
  市瀬浩志
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
ゲノム研究基軸放線菌における抗生物質生合成遺伝子機能の網羅的解析Principal Investigator
- Principal Investigator
  
  市瀬浩志
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Functional Analysis of Genes Encoding Glycosyltransferases Involved in the Biosynthesis of Deoxysugar-containing AntibioticsPrincipal Investigator
- Principal Investigator
  
  ICHINOSE Koji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  化学系薬学
- Research Institution
  The University of Tokyo
ゲノム研究基軸放線菌における抗生物質生合成遺伝子機能の網羅的解析Principal Investigator
- Principal Investigator
  
  市瀬浩志
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
ゲノム研究基軸放線菌における抗生物質生合成遺伝子機能の網羅的解析Principal Investigator
- Principal Investigator
  
  市瀬浩志
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Functional Analysis of Biosynthetic Enzymes for Natural Products
- Principal Investigator
  
  EBIZUKA Yutaka
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
ステロイドサポニンの生合成機構解明を基軸とする薬用遺伝子資源の探索と利用Principal Investigator
- Principal Investigator
  
  市瀬浩志
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
放射菌ポリケタイド系配糖体抗生物質の合理的分子設計とその生産Principal Investigator
- Principal Investigator
  
  市瀬浩志
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo

All 2020 2019 2017 2012 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Unveiling Two Consecutive Hydroxylations: Mechanisms of Aromatic Hydroxylations Catalyzed by Flavin-Dependent Monooxygenases for the Biosynthesis of Actinorhodin and Related Antibiotics2020
- Author(s)
  Hashimoto Makoto、Taguchi Takaaki、Ishikawa Kazuki、Mori Ryuichiro、Hotta Akari、Watari Susumu、Katakawa Kazuaki、Kumamoto Takuya、Okamoto Susumu、Ichinose Koji
- Journal Title
  
  ChemBioChem
  
  Volume: 21 Pages: 623-627
- DOI
  10.1002/cbic.201900490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03385, KAKENHI-PROJECT-17K08350
[Journal Article] Practical procedures for genetic manipulation systems for medermycin-producing Streptomyces sp.AM-7161.2010
- Author(s)
  Huiqun Deng, Xiaofeng Cai, Jianxin Peng, Huazhu Hong, Koji Ichinose, Aiying Li
- Journal Title
  
  J.Basic Microbiol. 50
  
  Pages: 299-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20510205
[Journal Article] Biosynthesis of Actinorhodin and Related Antibiotics : Discovery of Alternative Routes for Quinone Formation Encoded in the act Gene Cluster.2009
- Author(s)
  Susumu Okamoto, Takaaki Taguchi, Kozo Ochi, Koji Ichinose
- Journal Title
  
  Chem.Biol. 16
  
  Pages: 226-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20510205
[Journal Article] Actinoperylone, a novel perylenequinone-type shunt product, form a deletion mutant of the actVA-ORF5 and ORF6 genes for actinorhodin biosynthesis in Streptomyces coelicolor A3(2)2008
- Author(s)
  Takaaki Taguchi., Susumu Okamoto, Takayuki Itoh, Yutaka Ebizuka, Kozo Ochi, Koji Ichinose
- Journal Title
  
  Tetrahedron Lett. 49
  
  Pages: 1208-1211
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510184
[Journal Article] Actinorhodin Biosynthesis : Structural Requirements for Post-PKS Tailoring Intermediates Revealed by Functional Analysis of ActVI-ORF1 Reductase.2007
- Author(s)
  Takayuki Itoh, Takaaki Taguchi, Meriel R. Kimberley, Kevin I. Booker-Milburn, G. Richard Stephenson, Yutaka Ebizuka, Koji Ichinose
- Journal Title
  
  Biochemistry 46
  
  Pages: 8181-8188
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510184
[Journal Article] Functional Studies on a Ketoreductase Gene from Streptomyces sp.AM-7161 to Control the Stereochemistry in Medermycin Biosynthesis.2005
- Author(s)
  Aiying Li, Takayuki Itoh, Takaaki Taguchi, Ting Xiang, Yutaka Ebizuka, Koji Ichinose
- Journal Title
  
  Bioorganic & Medicinal Chemistry 13
  
  Pages: 6856-6863
- Data Source
  KAKENHI-PROJECT-17510184
[Journal Article] Functional studies on a ketoreductase gene from Streptomyces sp. AM-7161 to control the stereochemistry in medermycin biosynthesis2005
- Author(s)
  Aiying Li, Takayuki Itoh, Takaaki Taguchi, Ting Xiang., Yutaka Ebizuka, Koji Ichinose
- Journal Title
  
  Bioorg. Med. Chem. 13
  
  Pages: 6856-6863
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510184
[Presentation] アクチノロジン生合成におけるアリールカップリング反応機構の解析（第1報）2020
- Author(s)
  渡進，橋元誠，田口貴章，石川和樹，岡本晋，市瀬浩志
- Organizer
  日本薬学会第140回年会（京都）
- Data Source
  KAKENHI-PROJECT-19H03385
[Presentation] アクチノロジン生合成における連続水酸化反応機構の解析（第6報）2020
- Author(s)
  網野祐，橋元誠，田口貴章，石川和樹，熊本卓哉，岡本晋，市瀬浩志
- Organizer
  日本薬学会第140回年会（京都）
- Data Source
  KAKENHI-PROJECT-19H03385
[Presentation] アクチノロジン生合成に関与する二機能性酵素の同定と特性解析2019
- Author(s)
  市瀬浩志，田口貴章，淡川孝義，橋元誠，石川和樹，片川和明，熊本卓哉，大西康夫，岡本晋
- Organizer
  第61回天然有機化合物討論会（広島）
- Data Source
  KAKENHI-PROJECT-19H03385
[Presentation] アクチノロジン生合成に関与する二機能性酵素の同定と特性解析2019
- Author(s)
  市瀬浩志，田口貴章，淡川孝義，橋元誠，石川和樹，片川和明，熊本卓哉，大西康夫，岡本晋
- Organizer
  第61回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-17K08350
[Presentation] アクチノロジン生合成における連続水酸化反応機構の解析（第5報）2019
- Author(s)
  橋元誠, 田口貴章，石川和樹，熊本卓哉，岡本晋，市瀬浩志
- Organizer
  第34回（2019年度）日本放線菌学会大会（札幌）
- Data Source
  KAKENHI-PROJECT-19H03385
[Presentation] Actinorhodin生合成に関与する立体特異的エノイル還元酵素の機能解析2019
- Author(s)
  石川和樹、小松薫平、太田千裕、橋元誠、田口貴章、市瀬浩志
- Organizer
  日本薬学会　第139回年会（2019年3月22日　千葉）
- Data Source
  KAKENHI-PROJECT-17K08350
[Presentation] ベンゾイソクロマンキノン系抗生物質生合成に関与するフラビン依存型酸素添加酵素のホモロジーモデリングによる立構造予測と機能選択性解析2019
- Author(s)
  渡進，田口貴章，橋元誠，石川和樹，市瀬浩志
- Organizer
  第63回日本薬学会　関東支部大会（東京）
- Data Source
  KAKENHI-PROJECT-19H03385
[Presentation] アクチノロジン生合成における後期修飾過程のin vitro再構成検討2019
- Author(s)
  田口貴章、橋元誠、石川和樹、岡本晋、市瀬浩志
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K08350
[Presentation] アクチノロジン生合成における連続水酸化反応機構の解析（第3報）2017
- Author(s)
  森隆一郎, 田口貴章, 金井祐城, 丸和稔, 熊本卓哉, 岡本晋, 市瀬浩志
- Organizer
  2017年度（第32回）日本放線菌学会大会（長野）
- Data Source
  KAKENHI-PROJECT-17K08350
[Presentation] Functional Analysis of Oxidative Tailoring Enzymes in the Biosynthesis of Aromatic Polyketides2012
- Author(s)
  Koji Ichinose
- Organizer
  The International Conference of Natural Product Biosynthesis 8th US-Japan Seminar: Enzymology・Structural Biology・Drug Discovery・Genome Mining
- Place of Presentation
  淡路夢舞台国際会議場（兵庫県）
- Data Source
  KAKENHI-PUBLICLY-23108526
[Presentation] Biosynthetic studies on benzoisochromanequineone(BIQ) antibiotics(26) actVA-ORF5 disruptant-2008
- Author(s)
  Takaaki Taguchi, Susumu Okamoto, Takayuki Itoh, Yutaka Ebizuka, Koji Ichinose
- Organizer
  The 127th annual meeting of the pharma-ceutical Society of Japan
- Place of Presentation
  Yokohama
- Year and Date
  2008-03-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510184
[Presentation] Substrate recognition of modification enzymes involved in the biosynthesis of actinomycetes antibiotics2007
- Author(s)
  Koji Ichinose
- Organizer
  The 127th annual meeting of the pharma-ceutical Society of Japan(Sympsium 36)
- Place of Presentation
  Toyama
- Year and Date
  2007-03-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510184
[Presentation] 放線菌抗生物質生合成に関わる構造修飾酵素の基質認識2007
- Author(s)
  市瀬浩志
- Organizer
  日本薬学会第127年会シンポジウム36"生合成機構の解明から有用物質生産系の構築へ"
- Place of Presentation
  富山県民会館(富山)
- Year and Date
  2007-03-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510184
[Presentation] Biosynthetic studies on benzoisochromanequineone(BIQ) antibiotics(26) -Isolation and structural analysis of a novel compound from actVA-ORF5 disruptant-2007
- Author(s)
  Takaaki Taguchi, Susumu Okamoto, Takayuki Itoh, Tomoyo Masuda Yutaka Ebizuka, Koji Ichinose
- Organizer
  The annual meeting of the society for actinomycetes Japan
- Place of Presentation
  Onomichi
- Year and Date
  2007-06-01
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510184
[Presentation] Chemical tools to probe the enantioselectivity of RED1/RED2 reductions in polyketide tailoring steps2006
- Author(s)
  G Richard Stephenson, Emma Brennand, Cole Clissold, Kevin I, Booker-Milburn, Koji Ichinose
- Organizer
  Chemical Biology : Directing Biosynthesis(The Royal Society of Chemistry)
- Place of Presentation
  Cambridge, UK
- Year and Date
  2006-09-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510184
[Presentation] Purification and enzymatic analysis of stereospecific ketoreductase(RED1) involved in actinorhodin biosynthesis2006
- Author(s)
  Takayuki Itoh, Takaaki Taguchi, Yutaka Ebizuka, Koji Ichinose
- Organizer
  International Conference on Biodiversity and Natural Products(ICOB-5 & ISCNP-25)
- Place of Presentation
  Kyoto
- Year and Date
  2006-07-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510184
[Presentation] Functional analysis of a stereospecific ketoreductase involved in actinorhodin biosynthesis2006
- Author(s)
  Koji Ichinose, Takayuki Itoh, Takaaki Taguchi, Yutaka Ebizuka
- Organizer
  10th International Symposium on the Gnetics of Industrial Microorganisms(GIM2006)
- Place of Presentation
  Praque, Czeck
- Year and Date
  2006-06-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510184
[Presentation] Biosynthetic studies on deoxysugar(4) -Functional analysis of deoxyaminosugar biosynthetic genes involved in medermycin biosynthesis2006
- Author(s)
  Makoto Hashimoto, takaaki Taguchi, Koji Ichinose
- Organizer
  The annual meeting of the Japan Society for Bioscience, Biotechnology, and Agrocchemistry
- Place of Presentation
  Kyoto
- Year and Date
  2006-03-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510184
[Presentation] Functional analysis of a stereospecific ketoreductase involved in actinorhodin biosynthesis2006
- Author(s)
  Koji Ichinose
- Organizer
  10th International Symposium on the Gnetics of Industrial Microorganisms(GIM2006)
- Place of Presentation
  プラハ国際会議場(チェコ)
- Year and Date
  2006-06-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510184
[Presentation] Biosynthetic studies on benzoisochromanequineone(BIQ) antibiotics(26) -Purification and enzymatic analysis of act VI-ORFI gene product, RED1-2006
- Author(s)
  Takayuki Itot, Takaaki Taguchi, Yutaka Ebizuka, Koji Ichinose
- Organizer
  The 126th annual meeting of the pharma-ceutical society of Japan
- Place of Presentation
  Sendai
- Year and Date
  2006-03-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510184

1. TAGUCHI Takaaki (80409383)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. EBIZUKA Yutaka (90107384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. FUJII Isao (70181302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 石川和樹 (30779822)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 熊本卓哉 (50292678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 橋元誠 (80552893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

ICHINOSE Koji 市瀬 浩志

市瀬 浩志 イチノセ コウジ

Research Projects

Research Products

Co-Researchers

Generation of highly functionalized naphthoquiones based on the mechanistic understanding of biosynthetic enzymesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biosynthetic studies of aromatic polyketides to overcome tetracyclin-resistance of Escherichia coli.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アクノロジン生産完全再構成系による単機能反復型生合成反応の網羅的分子機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

芳香族ポリケタイド生合成マシナリー再構築に向けた比較ゲノム機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of the enzymes involved in the structural modification of polyketides and its application to the production of novel scaffoldsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Production of novel biologically active molecules based on the functional analysis of glycosylation enzymes related to secondary metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ゲノム研究基軸放線菌における抗生物質生合成鍵酵素の構造予測と機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ゲノム研究基軸放線菌における抗生物質生合成遺伝子機能の網羅的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional Analysis of Genes Encoding Glycosyltransferases Involved in the Biosynthesis of Deoxysugar-containing AntibioticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ゲノム研究基軸放線菌における抗生物質生合成遺伝子機能の網羅的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ゲノム研究基軸放線菌における抗生物質生合成遺伝子機能の網羅的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional Analysis of Biosynthetic Enzymes for Natural Products

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ステロイドサポニンの生合成機構解明を基軸とする薬用遺伝子資源の探索と利用Principal Investigator

Principal Investigator

Project Period (FY)

ICHINOSE Koji 市瀬浩志

市瀬浩志イチノセコウジ