Taguchi Takaaki 田口貴章

… Alternative Names

Researcher Number	80409383
Other IDs
Affiliation (Current)	2021: 国立医薬品食品衛生研究所, 食品部, 室長
Affiliation (based on the past Project Information) *help	2017 – 2019: 国立医薬品食品衛生研究所, 食品部, 室長 2010: 武蔵野大学, 薬学研究所, 講師 2007 – 2009: Musashino University, 薬学研究所, 助教 2006: 武蔵野大学, 薬学研究所, 助手
Review Section/Research Field	Principal Investigator Living organism molecular science / Natural medicines Except Principal Investigator Living organism molecular science
Keywords	Principal Investigator 放線菌 / アクチノロジン / 生合成 / hydroxylase / monooxygenase / actVA-ORF5 / actVA-ORF6 / ランドマイシン / 酸素添加 / 水酸化 … More Except Principal Investigator 抗生物質 / 生合成 / 放線菌 / フラビン酵 / 酸素添加 / フラビン酵素 / 酵素添加 Less

Biosynthetic studies of aromatic polyketides to overcome tetracyclin-resistance of Escherichia coli.Principal Investigator
- Principal Investigator
  
  Taguchi Takaaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  National Institute of Health Sciences
Functional analysis of the enzymes involved in the structural modification of polyketides and its application to the production of novel scaffolds
- Principal Investigator
  
  ICHINOSE Koji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Musashino University
Functional Studies on Monooxygenase/Hydroxylase involved in the biosyntheses of aromatic polyketidesPrincipal Investigator
- Principal Investigator
  
  TAGUCHI Takaaki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Musashino University

All 2020 2019 2017 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Unveiling Two Consecutive Hydroxylations: Mechanisms of Aromatic Hydroxylations Catalyzed by Flavin-Dependent Monooxygenases for the Biosynthesis of Actinorhodin and Related Antibiotics2020
- Author(s)
  Hashimoto Makoto、Taguchi Takaaki、Ishikawa Kazuki、Mori Ryuichiro、Hotta Akari、Watari Susumu、Katakawa Kazuaki、Kumamoto Takuya、Okamoto Susumu、Ichinose Koji
- Journal Title
  
  ChemBioChem
  
  Volume: 21 Pages: 623-627
- DOI
  10.1002/cbic.201900490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03385, KAKENHI-PROJECT-17K08350
[Journal Article] Biosynthesis of Actinorhodin and Related Antibiotics : Discovery of Alternative Routes for Quinone Formation Encoded in the act Gene Cluster.2009
- Author(s)
  Susumu Okamoto, Takaaki Taguchi, Kozo Ochi, Koji Ichinose
- Journal Title
  
  Chem.Biol. 16
  
  Pages: 226-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20510205
[Journal Article] Biosynthesis of Actinorhodin and Related Antibiotics : Discovery of Alternative Routes for Quinone Formation Encoded in the act Gene Cluster2009
- Author(s)
  Okamoto, S., Taguchi, T., Ochi, K., Ichinose, K.
- Journal Title
  
  Chem. Biol 16
  
  Pages: 226-236
- Data Source
  KAKENHI-PROJECT-18710189
[Journal Article] Actinoperylone, a novel perylene-quinone-type shunt product, from a deletion mutant of the actVA-ORF5 and ORF6 genes for actinorhodin biosynthesis in Streptomyces coelicolor A3(2).2008
- Author(s)
  Taguchi, T., Okamoto, S., Itoh, T., Ebizuka, Y., Ochi, K, Ichinose, K
- Journal Title
  
  Tetrahedron Lett. 49,
  
  Pages: 1208-1211
- Data Source
  KAKENHI-PROJECT-18710189
[Journal Article] Actinoperylone, a novel perlenequinone-type shunt product, from a deletion mutant of the actVA-ORF5 and ORF6 genes for actinorhodin biosynthesis in Streptomyces coelicolor A3(2)2008
- Author(s)
  Takaaki Taguchi
- Journal Title
  
  Tetrahedron Letters 49
  
  Pages: 1208-1211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18710189
[Journal Article] Possible involvement of ActVI-ORFA in transcriptional regulation of actVI tailoring-step genes for actinorhodin biosynthesis2007
- Author(s)
  Takaaki Taguchi, Susumu Okamoto, Alexander Lezhava, Aiying Li, Kozo Ochi, Yutaka Ebizuka, Koji Ichinose
- Journal Title
  
  FEMS Microbiology Letters (未定)(In press)
- Data Source
  KAKENHI-PROJECT-18710189
[Presentation] アクチノロジン生合成に関与する二機能性酵素の同定と特性解析2019
- Author(s)
  市瀬浩志，田口貴章，淡川孝義，橋元誠，石川和樹，片川和明，熊本卓哉，大西康夫，岡本晋
- Organizer
  第61回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-17K08350
[Presentation] Actinorhodin生合成に関与する立体特異的エノイル還元酵素の機能解析2019
- Author(s)
  石川和樹、小松薫平、太田千裕、橋元誠、田口貴章、市瀬浩志
- Organizer
  日本薬学会　第139回年会（2019年3月22日　千葉）
- Data Source
  KAKENHI-PROJECT-17K08350
[Presentation] アクチノロジン生合成における後期修飾過程のin vitro再構成検討2019
- Author(s)
  田口貴章、橋元誠、石川和樹、岡本晋、市瀬浩志
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K08350
[Presentation] アクチノロジン生合成における連続水酸化反応機構の解析（第3報）2017
- Author(s)
  森隆一郎, 田口貴章, 金井祐城, 丸和稔, 熊本卓哉, 岡本晋, 市瀬浩志
- Organizer
  2017年度（第32回）日本放線菌学会大会（長野）
- Data Source
  KAKENHI-PROJECT-17K08350
[Presentation] アクチノロジン生合成におけるモノオキシゲナーゼ酵素系ActVA-5/ActVBのエポキシ化活性の発見と解析2010
- Author(s)
  田口貴章
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20510205
[Presentation] Actinorhodin及びalunumycinの生合成に関わる二成分系モノオキシゲナーゼの機能解析2010
- Author(s)
  田口貴章
- Organizer
  日本放線菌学会2010年度大会
- Place of Presentation
  東京
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-20510205
[Presentation] アクチノロジン生合成におけるモノオキシゲナーゼ酵素系ActVA-5/ActVBのエポキシ化活性の発見と解析2010
- Author(s)
  田口貴章
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山大学津島キャンパス
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20510205
[Presentation] Actinorhodin及びalunumycinの生合成に関わる二成分系モノオキシゲナーゼの機能解析2010
- Author(s)
  田口貴章
- Organizer
  日本放線菌学会 2010年度大会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-20510205
[Presentation] アクチノロジン生合成における立体特異的還元酵素ActVI-2の機能解析2009
- Author(s)
  田口貴章
- Organizer
  日本薬学会第129年会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-18710189
[Presentation] Discovery of alternative routes for actinorhodin quinone formation2009
- Author(s)
  田口貴章
- Organizer
  15th International Symposium on the Biology of Actinomycetes (ISBA15)
- Place of Presentation
  Shanghai, PRC
- Year and Date
  2009-08-21
- Data Source
  KAKENHI-PROJECT-20510205
[Presentation] Actinorhodin生合成に関わるActVA-5/ActVB酵素系のモノオキシゲナーゼ活性の検討2009
- Author(s)
  田口貴章
- Organizer
  日本放線菌学会2009年度大会
- Place of Presentation
  秋田
- Year and Date
  2009-07-16
- Data Source
  KAKENHI-PROJECT-20510205
[Presentation] ベンゾイソクロマンキノン(BIQ)抗生物質の生合成研究(28)・actVA-ORF5破壊体の生産する新規化合物の単離・構造決定2008
- Author(s)
  田口貴章、岡本晋、伊藤崇敬、海老塚豊、越智幸三、市瀬浩志
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-18710189
[Presentation] Actinorhodin生合成におけるActVA-5,ActVA-6の機能解析2008
- Author(s)
  田口貴章、岡本晋、越智幸三、市瀬浩志
- Organizer
  日本放線菌学会2008年度大会
- Place of Presentation
  山梨
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-18710189
[Presentation] Actinorhodin生合成後期修飾過程における酸素導入に関する新たな知見2008
- Author(s)
  田口貴章
- Organizer
  第50回天然有機化合物討論会
- Place of Presentation
  福岡国際会議場(福岡)
- Year and Date
  2008-09-30
- Data Source
  KAKENHI-PROJECT-18710189
[Presentation] Actinorhodin生合成後期修飾過程における酸素導入に関する新たな知見2008
- Author(s)
  田口貴章
- Organizer
  第5 0回天然有機化合物討論会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2008-09-30
- Data Source
  KAKENHI-PROJECT-20510205
[Presentation] Actinorhodin生合成におけるActVA-5,ActVA-6の機能解析2008
- Author(s)
  田口貴章
- Organizer
  日本放線菌学会2008年度大会
- Place of Presentation
  山梨
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20510205
[Presentation] Actinorhodin生合成におけるActVA-5, ActVA-6の機能解析2008
- Author(s)
  田口貴章
- Organizer
  日本放線菌学会2008年度大会
- Place of Presentation
  フルーツバーク富士屋ホテル(山梨)
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-18710189
[Presentation] Actinorhodin生合成にかかわる立体特異的還元酵素RED1の構造と基質認識機構の予測2008
- Author(s)
  田口貴章
- Organizer
  日本放線菌学会2008年度大会
- Place of Presentation
  フルーツハーク富士屋ホテル(山梨)
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-18710189
[Presentation] ベンゾイソクロマン系抗生物質の生合成研究(28)-actVA-ORF5,6破壊体からの新規化合物の単離・構造決定-2008
- Author(s)
  田口貴章
- Organizer
  日本薬学会第128年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-18710189
[Presentation] Actinorhodin生合成後期修飾過程における酸素導入に関する新たな知見2008
- Author(s)
  田口貴章
- Organizer
  第50回天然有機化合物討論会
- Place of Presentation
  福岡
- Year and Date
  2008-09-30
- Data Source
  KAKENHI-PROJECT-20510205
[Presentation] Actinorhodin生合成後期修飾過程における酸素導入に関する新たな知見2008
- Author(s)
  田口貴章、岡本晋、伊藤崇敬、海老塚豊、越智幸三、市瀬浩志
- Organizer
  第50回天然有機化合物討論会
- Place of Presentation
  福岡
- Year and Date
  2008-09-30
- Data Source
  KAKENHI-PROJECT-18710189
[Presentation] ベンゾイソクロマンキノン(BIQ)抗生物質の生合成研究(27)・actVA-ORF5破壊体の生産する新規化合物の単離と構造解析2007
- Author(s)
  田口貴章、岡本晋、伊藤崇敬、増田智代、海老塚豊、越智幸三、市瀬浩志
- Organizer
  日本放線菌学会2007年度大会
- Place of Presentation
  尾道
- Year and Date
  2007-06-01
- Data Source
  KAKENHI-PROJECT-18710189

1. ICHINOSE Koji (40282610)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. 熊本卓哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 橋元誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Taguchi Takaaki 田口 貴章

TAGUCHI Takaaki 田口 貴章

Research Projects

Research Products

Co-Researchers

Biosynthetic studies of aromatic polyketides to overcome tetracyclin-resistance of Escherichia coli.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of the enzymes involved in the structural modification of polyketides and its application to the production of novel scaffolds

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional Studies on Monooxygenase/Hydroxylase involved in the biosyntheses of aromatic polyketidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Unveiling Two Consecutive Hydroxylations: Mechanisms of Aromatic Hydroxylations Catalyzed by Flavin-Dependent Monooxygenases for the Biosynthesis of Actinorhodin and Related Antibiotics2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biosynthesis of Actinorhodin and Related Antibiotics : Discovery of Alternative Routes for Quinone Formation Encoded in the act Gene Cluster.2009

Author(s)

Journal Title

Data Source

[Journal Article] Biosynthesis of Actinorhodin and Related Antibiotics : Discovery of Alternative Routes for Quinone Formation Encoded in the act Gene Cluster2009

Author(s)

Journal Title

Data Source

[Journal Article] Actinoperylone, a novel perylene-quinone-type shunt product, from a deletion mutant of the actVA-ORF5 and ORF6 genes for actinorhodin biosynthesis in Streptomyces coelicolor A3(2).2008

Author(s)

Journal Title

Data Source

[Journal Article] Actinoperylone, a novel perlenequinone-type shunt product, from a deletion mutant of the actVA-ORF5 and ORF6 genes for actinorhodin biosynthesis in Streptomyces coelicolor A3(2)2008

Author(s)

Journal Title

Data Source

[Journal Article] Possible involvement of ActVI-ORFA in transcriptional regulation of actVI tailoring-step genes for actinorhodin biosynthesis2007

Author(s)

Journal Title

Data Source

[Presentation] アクチノロジン生合成に関与する二機能性酵素の同定と特性解析2019

Author(s)

Organizer

Data Source

[Presentation] Actinorhodin生合成に関与する立体特異的エノイル還元酵素の機能解析2019

Author(s)

Organizer

Data Source

[Presentation] アクチノロジン生合成における後期修飾過程のin vitro再構成検討2019

Author(s)

Organizer

Data Source

[Presentation] アクチノロジン生合成における連続水酸化反応機構の解析（第3報）2017

Author(s)

Organizer

Data Source

[Presentation] アクチノロジン生合成におけるモノオキシゲナーゼ酵素系ActVA-5/ActVBのエポキシ化活性の発見と解析2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Actinorhodin及びalunumycinの生合成に関わる二成分系モノオキシゲナーゼの機能解析2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] アクチノロジン生合成におけるモノオキシゲナーゼ酵素系ActVA-5/ActVBのエポキシ化活性の発見と解析2010

Author(s)

Organizer

Place of Presentation

Taguchi Takaaki 田口貴章

TAGUCHI Takaaki 田口貴章