NAKAYAMA Nobuaki 中山伸朗

… Alternative Names

中山伸朗ナカヤマノブアキ

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Researcher Number	40292015
Other IDs
Affiliation (Current)	2025: 埼玉医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2013 – 2015: 埼玉医科大学, 医学部, 准教授 2004: Saitama Medical School, Department of Medicine, Assistant Professor, 医学部, 講師 2003: 埼玉医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator Serine protease / Acetaminophen / Ethanol / HepG2 cells / Apoptosis / セリンプロテアーゼ / アセトアミノフェン / エタノール / HepG2細胞 / アポトーシス … More Except Principal Investigator … More Huh7 / ポリメラーゼ / B型慢性肝炎 / 核酸アナログ / cyclingprobereal-timePCR / nucleotide analogs / nucleoside / terminal protein domain / polymerase / HCV / HBV Less

The aa15-17 amino acid sequence in the terminal protein domain of HBV polymerase as a viral factor affect-ing in vivo as well as in vitro replication activity of the virus.
- Principal Investigator
  
  Mochida Satoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical University
Apoptosis via new serine proteases and its intracellular signaling events.Principal Investigator
- Principal Investigator
  
  NAKAYAMA Nobuaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical School

All 2016 2015 2014 2013 2003 Other

All Journal Article Presentation Other

[Journal Article] Nationwide prospective and retrospective surveys for hepatitis B virus reactivation during immunosuppressive therapies.2016
- Author(s)
  Mochida S, Nakao M, Nakayama N, Uchida Y, Nagoshi S, Ido A, Mimura T, Harigai M, Kaneko H, Kobayashi H, Tsuchida T, Suzuki H, Ura N, Nakamura Y, Bessho M, Dan K, Kusumoto S, Sasaki Y, Fujii H, Suzuki F, Ikeda K, Yamamoto K, Takikawa H, Tsubouchi H, Mizokami M.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: Feb 1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] Development of rare RAVs that are extremely tolerant against NS5A inhibitors during daclatasvir/asunaprevir therapy via a two-hit mechanism.2016
- Author(s)
  Uchida Y, Kouyama J, Naiki K, Sugawara K, Inao M, Imai Y, Nakayama N, Mochida S.
- Journal Title
  
  Hepatology Research
  
  Volume: Feb 15 Issue: 12 Pages: 1234-1246
- DOI
  10.1111/hepr.12673
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] Significance of variants associated with resistance to NS5A inhibitors in Japanese patients with genotype 1b hepatitis C virus infection as evaluated using cycling-probe real-time PCR combined with direct sequencing.2016
- Author(s)
  Uchida Y, Kouyama J, Naiki K, Sugawara K, Ando S, Nakaoa M, Motoya D, Inao M, Imai Y, Nakayama N, Mochida S.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 51 Issue: 3 Pages: 260-270
- DOI
  10.1007/s00535-015-1106-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] Prospective randomized study comparing enhancement of the antiviral efficacy between vitamin D3 (cholecalciferol) and 1α(OH) D3 (alfacalcidol) in combination with pegylated interferon plus ribavirin for patients with chronic hepatitis C.2015
- Author(s)
  Mizuno Y, Nakayama N, Inao M, Funyu J, Asabe S, Tomita K, Nishikawa K, Hosoda Y, Tanaka M, Hashimoto Y, Takabayashi H, Yakabi K, Koshima K, Mochida S
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] Multicenter prospective study to optimize the efficacy of triple therapy with telaprevir in patients with genotype 1b HCV infection according to an algorithm based on the drug adherence, IL28B gene allele and viral response: the AG & RGT Trial.2015
- Author(s)
  Sugawara K, Koushima Y, Inao M, Nakayama N, Nagoshi S, Yakabi K, Tamano M, Asabe S, Mishikawa K, Harada Y, Sekine C, Fukuya Y, Funtny J, Hashimoto Y, Mochida S
- Journal Title
  
  Hepatol Res
  
  Volume: in press Issue: 11 Pages: 1091-1099
- DOI
  10.1111/hepr.12475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] Telaprevir-Induced, but not Pegylated Interferon-Associated, Retinopathy as a Noteworthy Adverse Effect during Triple Antiviral Therapy in Patients with Chronic Hepatitis C.2014
- Author(s)
  Sugawara K, Inao M, Nakayama N, Mochida S.
- Journal Title
  
  J Gastroenterol
  
  Volume: 49 Pages: 363-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] Arterial Chemoembolization for Hepatocellular Carcinoma: Comparison of the Therapeutic Efficacies Between Miriplatin and Epirubicin.2014
- Author(s)
  Handa T, Imai Y, Sigawara K, Chikayama T, Nakazawa M, Ando S, Hamaorka K, Inao M, Nakayama N, Mochida S.
- Journal Title
  
  Hepatol Res
  
  Volume: in press Issue: 11 Pages: 1072-1080
- DOI
  10.1111/hepr.12225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] Classification of the etiologies of acute liver failure in Japan: A report by the Intractable Hepato-Biliary Diseases Study Group of Japan.2014
- Author(s)
  Mochida S, Takikawa Y, Nakayama N, Oketani M, Naiki T, Yamagishi Y, Fujiwara K, Ichida T, Tsubouchi H.
- Journal Title
  
  Hepatol Res
  
  Volume: in press Issue: 4 Pages: 365-367
- DOI
  10.1111/hepr.12295
- NAID
  130003393966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] A Possible Novel Genotype HBV Strain Developing Due to Recombination between Genotypes H and B Strains Isolated from a Japanese Patient.2014
- Author(s)
  Uchida Y, Kouyama J, Naiki K, Sugawara K, Inao M, Nakayama N, Mochida S
- Journal Title
  
  Hepatol Res
  
  Volume: in press Issue: 11 Pages: 1130-1141
- DOI
  10.1111/hepr.12238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] SNPs in the promoter region of osteopontin gene as a possible host factor for sex difference in hepatocellular carcinoma development in patients with HCV.2013
- Author(s)
  Hamaoka K, Nagoshi S, Sugawara K, Naiki K, Uchida Y, Inao M, Nakayama N, Fujiwara K, Mochida S.
- Journal Title
  
  Hepatol Int
  
  Volume: 7 Issue: 2 Pages: 683-692
- DOI
  10.1007/s12072-012-9404-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] 薬剤性肝細胞障害におけるアポトーシスの解析2003
- Author(s)
  中山伸朗他
- Journal Title
  
  肝臓 44・Suppl(1)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590682
[Journal Article] Apoptosis in drug-induced liver injuries2003
- Author(s)
  Nakayama N, Matsui A, Nagoshi S, Mochida S, Nakajima J, Koike T, Fujiwara K
- Journal Title
  
  Acta Hepatol Jpn 44 Suppl.1
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590682
[Journal Article] 薬剤性肝細胞障害におけるアポトーシスの解析2003
- Author(s)
  中山伸朗
- Journal Title
  
  肝臓 44・Suppl(1)
- Data Source
  KAKENHI-PROJECT-15590682
[Presentation] Frequent Emergences of Rare RAVs Showing Extreme Resistance to NS5A Inhibitors during Dual Oral Therapy with Daclatasvir Plus Asunaprevir in Patients Previously Receiving Triple Therapy with Simeprevir.2015
- Author(s)
  Yoshihito UCHIDA, Nobuaki NAKAYAMA, Jun-ichi KOUYAMA, Kayoko NAIKI, Hayato UEMURA, Kayoko SUGAWARA, Mie INAO, Satoshi MOCHIDA
- Organizer
  The Liver Meeting, AASLD
- Place of Presentation
  St Francisco,USA
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461010
[Presentation] B型肝炎の治療におけるテノホビルの意義2015
- Author(s)
  中尾将光，中山伸朗，持田　智
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本　ホテル日航熊本（熊本県熊本市）
- Year and Date
  2015-05-19
- Data Source
  KAKENHI-PROJECT-25461010
[Presentation] Clinical Features and Outcome of Patients with Acute Liver Failure and LOHF due to HBV Reactivation during and after Immunosuppressive and/or Anticancer Therapies Enrolled in Nationwide Survey in Japan2015
- Author(s)
  Nobuaki NAKAYAMA, Yoshihito UCHIDA, Masamitsu NAKAO, Hirohito TSUBOUCH, Hjime TAKIKAWA and Satoshi MOCHIDA
- Organizer
  The Liver Meeting, AASLD
- Place of Presentation
  St Francisco,USA
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461010
[Presentation] NS5Aアミノ酸変異を考慮したC型慢性肝疾患の治療戦略とダクラタスビル・アスナプレビル併用療法の有用性2015
- Author(s)
  中山伸朗，内田義人，持田　智
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本　ホテル日航熊本（熊本県熊本市）
- Year and Date
  2015-05-19
- Data Source
  KAKENHI-PROJECT-25461010
[Presentation] Nationwide Prospective Survey in Japan to Clarify the Incidence of Viral Reactivation in Patients with Prior HBV Infection Receiving Immunosuppressive Therapies2015
- Author(s)
  Masaaki NAKAO, Nobuaki NAKAYAMA, Yoshihito UCHIDA, Masashi MIZOKAMI and Satoshi MOCHIDA
- Organizer
  The Liver Meeting, AASLD
- Place of Presentation
  St Francisco,USA
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461010
[Presentation] The aa15-17 Amino Acid Sequence in the Terminal Protein Domain of the Hepatitis B Virus Polymerase as a Viral Factor Affecting Replication Activity of the Virus
- Author(s)
  Yoshihito UCHIDA, Jun-ichi KOUYAMA, Kayoko NAIKI, MasamitsuNAKAO, Nobuaki NAKAYAMA and Satoshi MOCHIDA
- Organizer
  第11回Single Topic Conference
- Place of Presentation
  ホテルグランヴィア広島（広島県広島市）
- Year and Date
  2014-11-20 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-25461010
[Presentation] The aa15-17 Amino Acid Sequence in the Terminal Protein Domain of HBV Polymerase as a Viral Factor Affecting in Vivo as Well as in Vitro Replication Activity of the Virus
- Author(s)
  Uchida Y, Yoshino K, Sugawara K, Kouyama J, Naiki K, Nakayama N, Mochida S
- Organizer
  The liver Meeting 2013 (AASLD)
- Place of Presentation
  Washington,USA
- Data Source
  KAKENHI-PROJECT-25461010
[]

1. Mochida Satoshi (20219968)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
2. Sugawara Michiko (20406458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. MATSUI Atsushi (40260484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. NAGOSHI Sumiko (50306271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. LNAO Mie (70286037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKAYAMA Nobuaki 中山 伸朗

中山 伸朗 ナカヤマ ノブアキ

Research Projects

Research Products

Co-Researchers

The aa15-17 amino acid sequence in the terminal protein domain of HBV polymerase as a viral factor affect-ing in vivo as well as in vitro replication activity of the virus.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Apoptosis via new serine proteases and its intracellular signaling events.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Nationwide prospective and retrospective surveys for hepatitis B virus reactivation during immunosuppressive therapies.2016

Author(s)

Journal Title

Data Source

[Journal Article] Development of rare RAVs that are extremely tolerant against NS5A inhibitors during daclatasvir/asunaprevir therapy via a two-hit mechanism.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Significance of variants associated with resistance to NS5A inhibitors in Japanese patients with genotype 1b hepatitis C virus infection as evaluated using cycling-probe real-time PCR combined with direct sequencing.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prospective randomized study comparing enhancement of the antiviral efficacy between vitamin D3 (cholecalciferol) and 1α(OH) D3 (alfacalcidol) in combination with pegylated interferon plus ribavirin for patients with chronic hepatitis C.2015

Author(s)

Journal Title

Data Source

[Journal Article] Multicenter prospective study to optimize the efficacy of triple therapy with telaprevir in patients with genotype 1b HCV infection according to an algorithm based on the drug adherence, IL28B gene allele and viral response: the AG & RGT Trial.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Telaprevir-Induced, but not Pegylated Interferon-Associated, Retinopathy as a Noteworthy Adverse Effect during Triple Antiviral Therapy in Patients with Chronic Hepatitis C.2014

Author(s)

Journal Title

Data Source

[Journal Article] Arterial Chemoembolization for Hepatocellular Carcinoma: Comparison of the Therapeutic Efficacies Between Miriplatin and Epirubicin.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Classification of the etiologies of acute liver failure in Japan: A report by the Intractable Hepato-Biliary Diseases Study Group of Japan.2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A Possible Novel Genotype HBV Strain Developing Due to Recombination between Genotypes H and B Strains Isolated from a Japanese Patient.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SNPs in the promoter region of osteopontin gene as a possible host factor for sex difference in hepatocellular carcinoma development in patients with HCV.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 薬剤性肝細胞障害におけるアポトーシスの解析2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Apoptosis in drug-induced liver injuries2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] 薬剤性肝細胞障害におけるアポトーシスの解析2003

Author(s)

Journal Title

Data Source

[Presentation] Frequent Emergences of Rare RAVs Showing Extreme Resistance to NS5A Inhibitors during Dual Oral Therapy with Daclatasvir Plus Asunaprevir in Patients Previously Receiving Triple Therapy with Simeprevir.2015

NAKAYAMA Nobuaki 中山伸朗

中山伸朗ナカヤマノブアキ