Shinmura Kazuya 新村和也

… Alternative Names

新村和也シンムラカズヤ

SHINMURA Kazuya 新村和也

Less

Researcher Number	40321880
Other IDs
Affiliation (Current)	2025: 浜松医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2024 – 2025: 浜松医科大学, 医学部, 教授 2022: 浜松医科大学, 医学部, 教授 2020 – 2021: 浜松医科大学, 医学部, 准教授 2008 – 2018: Hamamatsu University School of Medicine, 医学部, 准教授 2007: Hamamatsu University School of Medicine, 医学部, 助教 … More 2004: 国立大学法人浜松医科大学, 医学部, 特別研究員(PD) 2001 – 2002: 国立がんセンター, 研究所・生物学部, 研究員 2000: 国立がんセンター, 生物学部, 研究員 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Basic Section 49030:Experimental pathology-related / Experimental pathology / Pathological medical chemistry / Biological Sciences Except Principal Investigator Basic Section 49020:Human pathology-related / Digestive surgery
Keywords	Principal Investigator 中心体過剰複製 / 中心体 / DNA修復 / MUTYH / がん / 染色体不安定性 / DNAグリコシラーゼ / MYH遺伝子 / 遺伝子多型 / WDR62 … More / 遺伝子増幅 / 胃がん / SGOL1 / PLK4 / 中心体サイクル / B[a]PDE / 突然変異 / SNP / OGG1遺伝子 / 塩基除去修復 / 8-ヒドロキシグアニン / がん易罹患性 / 感受性因子 / 胃悪性リンパ腫 / NEIL1遺伝子 / 中心体・一次繊毛 / 腫瘍 / Shhシグナル経路 / 唾液腺腫瘍 / 電子顕微鏡 / 電界放出型走査電子顕微鏡 / 肺腫瘍 / 一次繊毛 / ナノスーツ法 / salivary gland tumor / lung cancer / primary cilia / electron microscopy / NanoSuit method / 予後 / 肺腺癌 / 8-bromoguanine / 染色体コピー数異常 / STIL / 中心体局在 / DNA グリコシラーゼ / POLQ / 中心体数的異常 / MUTYH関連ポリポーシス / DNA付加体 / DNA修復酵素遺伝子 / TDG / 予後不良因子 / ラギング染色体 / STK15 / NEIL / SASS6 / DNA repair / Centrosome amplification / 肺がん / 大腸がん / 色体不安定性 / AID / SUMO化 / EML4 / ヌクレオフオスミン / hSgol / P53 / がん抑制遺伝子 / EML4-ALK / 非小細胞肺がん / hSgo1 / ベンゾピレン / NORE1A / p53 / 翻訳効率 / OGGI遺伝子 / 突然変異率 / 前進突然変異 … More Except Principal Investigator ナノスーツ / 病理切片 / CLEM / 生体蛍光蛋白 / アルプミン / 免疫不全マウス / キメラマウス / トランスジェニックマエス / レトロウィルス / 化学発癌 / 癌遺伝子 / レンチウィルス / 遺伝子導入 / 細胞移植 / トランスジェニックマウス / 化学発ガン / 肝細胞癌 / マウス / ヒト肝細胞 Less

新規組織型群である一次繊毛陽性腫瘍の病理学的病態解明Principal Investigator
- Principal Investigator
  
  新村和也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Hamamatsu University School of Medicine
Establishment of Multimodal Translational Pathology Using NanoSuit-Scanning Electron Microscopy
- Principal Investigator
  
  河崎秀陽
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Hamamatsu University School of Medicine
Identification of novel tumor morphological features on HE-stained slides by electron microscopy observation using the NanoSuit methodPrincipal Investigator
- Principal Investigator
  
  Shinmura Kazuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Hamamatsu University School of Medicine
Characteristics of human cancers showing high-level centrosome amplification and their sensitivity to drugs targeting centrosome amplificationPrincipal Investigator
- Principal Investigator
  
  Shinmura Kazuya
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Hamamatsu University School of Medicine
Study on the mechanism underlying the centrosome amplification induced by DNA repair abnormality in cancerPrincipal Investigator
- Principal Investigator
  
  Shinmura Kazuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Hamamatsu University School of Medicine
Study on the abnormal centrosome regulation, leading to the chromosome instability in cancerPrincipal Investigator
- Principal Investigator
  
  SHINMURA Kazuya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Hamamatsu University School of Medicine
Generation of mice in which the mouse hepatocytes are replaced with the human hepaocytes and its application
- Principal Investigator
  
  MIURA Naoyuki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Hamamatsu University School of Medicine
Study on the abnormal centrosome regulation, leading to the chromosome instability in cancerPrincipal Investigator
- Principal Investigator
  
  SHINMURA Kazuya
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Hamamatsu University School of Medicine
胃悪性リンパ腫および胃がんの感受性因子に関する分子病理学的研究Principal Investigator
- Principal Investigator
  
  新村和也
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Experimental pathology
- Research Institution
  Hamamatsu University School of Medicine
ヒト塩基除去修復酵素の遺伝子多型に基づく活性の個体差に関する研究Principal Investigator
- Principal Investigator
  
  新村和也
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
ヒト塩基除去修復酵素の遺伝子多型に基づく活性の個体差に関する研究Principal Investigator
- Principal Investigator
  
  新村和也
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

[Book] Centrosome Abnormality and Human Lung Cancer in Lung Diseases - Selected State of the Art Reviews2012
- Author(s)
  Shinmura K
- Total Pages
  18
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-22590356
[Book] Centrosome Abnormality and Human Lung Cancer in Lung Diseases - Selected State of the Art Reviews、Irusen EM (Ed.)2012
- Author(s)
  Shinmura K, Sugimura H
- Publisher
  InTech, Rijeka, Croatia
- Data Source
  KAKENHI-PROJECT-22590356
[Journal Article] Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation2021
- Author(s)
  Shinmura K, Kusafuka K, Kawasaki H, Kato H, Hariyama T, Tsuchiya K, Kawanishi Y, Funai K, Misawa K, Mineta H, Sugimura H
- Journal Title
  
  Journal of Pathology
  
  Volume: - Issue: 5 Pages: 519-530
- DOI
  10.1002/path.5688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07445, KAKENHI-PROJECT-17K08784, KAKENHI-PROJECT-20K07390
[Journal Article] Diagnosis of Ion-Exchange Resin Depositions in Paraffin Sections Using Corrective Light and Electron Microscopy-NanoSuit Method2021
- Author(s)
  Ooishi Mako、Yamada Satoshi、Itoh Toshiya、Meguro Shiori、Yagi Haruna、Kosugi Isao、Iwashita Toshihide、Shinmura Kazuya、Misawa Kiyoshi、Hariyama Takahiko、Kawasaki Hideya
- Journal Title
  
  Diagnostics
  
  Volume: 11 Issue: 7 Pages: 1193-1193
- DOI
  10.3390/diagnostics11071193
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08784, KAKENHI-PROJECT-20K07390, KAKENHI-PROJECT-20K07445, KAKENHI-PROJECT-21K06947, KAKENHI-PROJECT-21K07816
[Journal Article] Defective repair capacity of variant proteins of the DNA glycosylase NTHL1 for 5-hydroxyuracil, an oxidation product of cytosine2019
- Author(s)
  Shinmura K, Kato H, Kawanishi Y, Goto M, Tao H, Yoshimura K, Nakamura S, Misawa K, Sugimura H
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 131 Pages: 264-273
- DOI
  10.1016/j.freeradbiomed.2018.12.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08709
[Journal Article] Reduced expression of the DNA glycosylase gene MUTYH is associated with an increased number of somatic mutations via a reduction in the DNA repair capacity in prostate adenocarcinoma.2017
- Author(s)
  Shinmura K, Kato H, Kawanishi Y, Yoshimura K, Igarashi H, Goto M, Tao H, Inoue Y, Sugiyama T, Furuse H, Ozono S, Sugimura H
- Journal Title
  
  Mol Carcinog
  
  Volume: 56(2) Issue: 2 Pages: 781-788
- DOI
  10.1002/mc.22509
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08709
[Journal Article] WDR62 overexpression is associated with a poor prognosis in patients with lung adenocarcinoma.2017
- Author(s)
  Shinmura K, Kato H, Kawanishi Y, Igarashi H, Inoue Y, Yoshimura K, Nakamura S, Fujita H, Funai K, Tanahashi M, Niwa H, Ogawa H, Sugimura H
- Journal Title
  
  Mol Carcinog
  
  Volume: 印刷中 Issue: 8 Pages: 1984-1991
- DOI
  10.1002/mc.22647
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08709, KAKENHI-PROJECT-16K15256
[Journal Article] Mutation Spectrum Induced by 8-Bromoguanine, a Base Damaged by Reactive Brominating Species, in Human Cells2017
- Author(s)
  Shinmura Kazuya、Kato Hisami、Goto Masanori、Tao Hong、Inoue Yusuke、Nakamura Satoki、Yoshida Haruki、Tsuzaki Emi、Sugimura Haruhiko
- Journal Title
  
  Oxidative Medicine and Cellular Longevity
  
  Volume: 2017 Issue: 1 Pages: 1-11
- DOI
  10.1155/2017/7308501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08709
[Journal Article] Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer.2016
- Author(s)
  Shinmura K, Kato H, Kawanishi Y, Igarashi H, Goto M, Tao H, Inoue Y, Nakamura S, Misawa K, Mineta H, Sugimura H.
- Journal Title
  
  Oxidative Medicine and Cellular Longevity
  
  Volume: 2016 Issue: 1 Pages: 1546392-1546392
- DOI
  10.1155/2016/1546392
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460476, KAKENHI-PROJECT-26670187, KAKENHI-PROJECT-26462599, KAKENHI-PROJECT-16K11228
[Journal Article] Functional Evaluation of Nine Missense-Type Variants of the Human DNA Glycosylase Enzyme MUTYH in the Japanese Population.2016
- Author(s)
  Shinmura K, Kato H, Goto M, Yamada H, Tao H, Nakamura S, Sugimura H.
- Journal Title
  
  Hum Mutat.
  
  Volume: 37 Issue: 4 Pages: 350-353
- DOI
  10.1002/humu.22949
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-25460476, KAKENHI-PROJECT-15K21054
[Journal Article] SASS6 overexpression is associated with mitotic chromosomal abnormalities and a poor prognosis in patients with colorectal cancer2015
- Author(s)
  Shinmura K, Kato H, Kawanishi Y, Nagura K, Kamo T, Okubo Y, Inoue Y, Kurabe N, Du C, Iwaizumi M, Kurachi K, Nakamura T, Sugimura H
- Journal Title
  
  Oncology Reports
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460476
[Journal Article] Human DNA glycosylase enzyme TDG repairs thymine mispaired with exocyclic etheno-DNA adducts2014
- Author(s)
  Goto M, Shinmura K, Matsushima Y, Ishino K, Yamada H, Totsuka Y, Matsuda T, Nakagama H, Sugimura H
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 76 Pages: 136-146
- DOI
  10.1016/j.freeradbiomed.2014.07.044
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460476, KAKENHI-PROJECT-26460469, KAKENHI-PROJECT-26670187
[Journal Article] TNK2 gene amplification is a novel predictor of a poor prognosis in patients with gastric cancer2014
- Author(s)
  Shinmura K, Sugimura H et al.
- Journal Title
  
  J Surg Oncol
  
  Volume: 109(3) Issue: 3 Pages: 189-97
- DOI
  10.1002/jso.23482
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659161, KAKENHI-PROJECT-25460384, KAKENHI-PROJECT-25460476, KAKENHI-PROJECT-221S0001
[Journal Article] PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer2014
- Author(s)
  Shinmura K, Kurabe N, Goto M, Yamada H, Natsume H, Konno H, Sugimura H
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 41 Issue: 10 Pages: 6635-6644
- DOI
  10.1007/s11033-014-3546-2
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460476, KAKENHI-PROJECT-221S0001
[Journal Article] Impaired 8-hydroxyguanine repair activity of MUTYH variant p. Arg109Trp found in a Japanese patient with early-onset colorectal cancer2014
- Author(s)
  Shinmura, K., Goto, M., Tao, H., Kato, H., Suzuki, R., Nakamura, S., Matsuda, T., Yin, G., Morita, M., Kono, S., Sugimura, H.
- Journal Title
  
  Oxidative Medicine and Cellular Longevity
  
  Volume: 2014 Pages: 617351-617351
- DOI
  10.1155/2014/617351
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23221006, KAKENHI-PROJECT-25460384, KAKENHI-PROJECT-25460476, KAKENHI-PROJECT-221S0001
[Journal Article] In silico evaluation of nonsynonymous single nucleotide polymorphisms in the TDG gene, which is involved in base excision repair2014
- Author(s)
  Shinmura K, Kato H, Goto M, Du C, Inoue Y, Nakamura S, Sugimura H
- Journal Title
  
  Annals of Clinical Pathology
  
  Volume: 2 Pages: 1014-1014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460476
[Journal Article] SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers2013
- Author(s)
  Matsuura S, Kahyo T, Shinmura K, Iwaizumi M, Yamada H, Funai K, Kobayashi J, Tanahashi M, Niwa H, Ogawa H, Takahashi T, Inui N, Suda T, Chida K, Watanabe Y, *Sugimura H.
- Journal Title
  
  Sci Rep
  
  Volume: 3 Issue: 1 Pages: 3012-3012
- DOI
  10.1038/srep03012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22134005, KAKENHI-PROJECT-24659161, KAKENHI-PROJECT-25250017, KAKENHI-PROJECT-25460476, KAKENHI-PROJECT-221S0001
[Journal Article] Impaired suppressive activities of human MUTYH variant proteins against oxidative mutagenesis2012
- Author(s)
  Shinmura K, Goto M, Tao H, Matsuura S, Matsuda T, Sugimura H
- Journal Title
  
  World J Gastroenterol
  
  Volume: 18 Issue: 47 Pages: 6935-6942
- DOI
  10.3748/wjg.v18.i47.6935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590356, KAKENHI-PROJECT-22790378, KAKENHI-PROJECT-24659161
[Journal Article] Role of base excision repair enzyme MUTYH in the repair of 8-hydroxyguanine and MUTYH-associated polyposis (MAP)2012
- Author(s)
  Shinmura K, Goto M, Tao H, Sugimura H
- Journal Title
  
  Hereditary Genet
  
  Volume: 1 Pages: 111-111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590356
[Journal Article] Role of base excision repair enzyme MUTYH in the repair of 8-hydroxyguanine and MUTYH-associated polyposis (MAP)2012
- Author(s)
  Shinmura K
- Journal Title
  
  Hered Genet
  
  Volume: 1 Issue: 03 Pages: 1000111-1000111
- DOI
  10.4172/2161-1041.1000111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590356
[Journal Article] Aberrant expression and mutation-inducing activity of AID in human lung cancer2011
- Author(s)
  Shinmura K, Igarashi H, Goto M, Tao H, Yamada H, Matsuura S, Tajima M, Matsuda T, Yamane A, Funai K, Tanahashi M, Niwa H, Ogawa H, Sugimura H
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 18 Issue: 7 Pages: 2084-2092
- DOI
  10.1245/s10434-011-1568-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590356, KAKENHI-PROJECT-22790378, KAKENHI-PROJECT-23221006
[Journal Article] Detection of kinase amplifications in gastric cancer archives using fluorescence in situ hybridization2011
- Author(s)
  Kiyose S, Nagura K, Tao H, Igarashi H, Yamada H, Goto M, Maeda M, Kurabe N, Suzuki M, Tsuboi M, Kahyo T, Shinmura K, Hattori N, Sugimura H
- Journal Title
  
  Pathol Int
  
  Volume: 62 Issue: 7 Pages: 477-484
- DOI
  10.1111/j.1440-1827.2012.02832.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590356, KAKENHI-PROJECT-24659161
[Journal Article] A novel tumor-derived SGOL1 variant causes abnormal mitosis and unstable chromatid cohesion2011
- Author(s)
  Kahyo T, Iwaizumi M, Shinmura K, Matsuura S, Nakamura T, Watanabe Y, Yamada H, Sugimura H
- Journal Title
  
  Oncogene
  
  Volume: 30 Issue: 44 Pages: 4453-4463
- DOI
  10.1038/onc.2011.152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590356
[Journal Article] Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer2011
- Author(s)
  Shinmura, et.Al
- Journal Title
  
  The Journal of Pathology
  
  Volume: 225 Issue: 3 Pages: 414-423
- DOI
  10.1002/path.2953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790383, KAKENHI-PROJECT-22590356, KAKENHI-PROJECT-22790378, KAKENHI-PROJECT-23221006
[Journal Article] Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma2011
- Author(s)
  Shinmura K, Tao H, Nagura K, Goto M, Matsuura S, Mochizuki T,SuzukiK, Tanahashi M, Niwa H, Ogawa H, Sugimura H
- Journal Title
  
  Lung Cancer
  
  Volume: 71 Issue: 1 Pages: 19-27
- DOI
  10.1016/j.lungcan.2010.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590356
[Journal Article] EML4-ALK fusion transcripts in immunohistochemically ALK-positive non-small cell lung carcinomas.2010
- Author(s)
  Shinmura K, Kageyama S, Igarashi H, Kamo T, Mochizuki T, Suzuki K, Tanahashi M, Niwa H, Ogawa H, Sugimura H
- Journal Title
  
  Exp Ther Med 1
  
  Pages: 271-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] 大腸癌においてシュゴシン(hSgo1)の低下は染色体不安定性を誘導する2010
- Author(s)
  岩泉守哉、新村和也、山田英孝、伊熊睦博、椙村春彦
- Journal Title
  
  INTESTINE
  
  Volume: 14 Pages: 320-322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590356
[Journal Article] Adenine DNA glycosylase activity of 14 Human MutY homolog (MUTYH) variant proteins found in patients with colorectal of osis and cancer2010
- Author(s)
  Goto M, Shinmura K, et al.
- Journal Title
  
  Hum Mutat
  
  Volume: 31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590356
[Journal Article] Adenine DNA glycosylase activity of 14 Human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer2010
- Author(s)
  Goto M, Shinmura K, Nakabeppu Y, Tao H, Yamada H, Tsuneyoshi T, Sugimura H
- Journal Title
  
  Hum Mutat
  
  Volume: 31 Issue: 11 Pages: 1861-1874
- DOI
  10.1002/humu.21363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590356, KAKENHI-PROJECT-22790378
[Journal Article] EML4-ALK fusion transcripts in immunohistochemically ALK-positive non-small cell lung carcinomas2010
- Author(s)
  Shinmura K, et al.
- Journal Title
  
  Exp Ther Med 1
  
  Pages: 271-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer.2009
- Author(s)
  Iwaizumi M, Shinmura K, Mori H, Yamada H, Suzuki M, Kitayama Y, Igarashi H, Nakamura T, Suzuki H, Watanabe Y, Hishida A, Ikuma M, Sugimura H
- Journal Title
  
  Gut 58
  
  Pages: 249-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] Altered expression of the human base excision repair gene NTH1 in gastric cancer.2009
- Author(s)
  Goto M, Shinmura K, Igarashi H, Kobayashi M, Konno H, Yamada H, Iwaizumi M, Kageyama S, Tsuneyoshi T, Tsugane S, Sugimura H
- Journal Title
  
  Carcinogenesis 30
  
  Pages: 1345-1352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] Association between genetic polymorphisms of the base excision repair gene MUTYH and increased colorectal cancer risk in a Japanese population.2008
- Author(s)
  Tao H, Shinmura K, Suzuki M, Kono S, Mibu R, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, Futami K, Yasunami Y, Maekawa T, Takenaka K, Ichimiya H, Imaizumi N, Sugimura H
- Journal Title
  
  Cancer Sci 99
  
  Pages: 355-360
- NAID
  10024002605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to benzo[a]pyrene diol epoxide (B[a]PDE).2008
- Author(s)
  Shinmura K, Iwaizumi M, Igarashi H, Nagura K, Yamada H, Suzuki M, Fukasawa K, Sugimura H
- Journal Title
  
  J Pathol 216
  
  Pages: 365-374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to benzo[a]pyrene diol epoxide (B[a]PDE)2008
- Author(s)
  Shinmura K, et.al.
- Journal Title
  
  J Pathol 216
  
  Pages: 365-374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas.2008
- Author(s)
  Shinmura K, Kageyama S, Tao H, Bunai T, Suzuki M, Kamo T, Takamochi K, Suzuki K, Tanahashi M, Niwa H, Ogawa H, Sugimura H
- Journal Title
  
  Lung Cancer 61
  
  Pages: 163-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication.2007
- Author(s)
  Shinmura K, Bennett RA, Tarapore P, Fukasawa K
- Journal Title
  
  Oncogene 26
  
  Pages: 2939-2944
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival.2007
- Author(s)
  Liu X, Liu Z, Jang SW, Ma Z, Shinmura K, Kang S, Dong S, Chen J, Fukasawa, K, Ye K
- Journal Title
  
  Proc Natl Acad Sci USA 104
  
  Pages: 9679-9684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication2007
- Author(s)
  Shinmura K, et. al.
- Journal Title
  
  Oncogene 26
  
  Pages: 2939-2944
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] Identification and characterization of a novel germ line p53 mutation in familial gastric cancer in the Japanese population.2007
- Author(s)
  Yamada H, Shinmura K, Okudela K, Goto M, Suzuki M, Kuriki K, Tsuneyoshi T, Sugimura H
- Journal Title
  
  Carcinogenesis 28
  
  Pages: 2013-2018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] EPHA2/EFNA1 expression in human gastric cancer.2005
- Author(s)
  Nakamura R., Shinmura K., Sugimura H.et al.
- Journal Title
  
  Cancer Sci. 96
  
  Pages: 42-47
- NAID
  10015523911
- Data Source
  KAKENHI-PROJECT-04J03680
[Journal Article] A novel STK11 germline mutation in two siblings with Peutz-Jeghers syndrome complicated by primary gastric cancer.2005
- Author(s)
  Shinmura K., Sugimura H.et al.
- Journal Title
  
  Clin.Genet. 67
  
  Pages: 81-86
- Data Source
  KAKENHI-PROJECT-04J03680
[Journal Article] Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity.2004
- Author(s)
  Shinmura K., Sugimura H.et al.
- Journal Title
  
  Hum.Mutat. 24
  
  Pages: 273-274
- Data Source
  KAKENHI-PROJECT-04J03680
[Journal Article] Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer.2004
- Author(s)
  Shinmura K., Sugimura H.et al.
- Journal Title
  
  Carcinogenesis 25
  
  Pages: 2311-2317
- Data Source
  KAKENHI-PROJECT-04J03680
[Journal Article] A novel splice-site variant of the base excision repair gene MYH is associated with production of an aberrant mRNA transcript encoding a truncated MYH protein not localized in the nucleus.2004
- Author(s)
  Tao H., Shinmura K., Sugimura H.et al.
- Journal Title
  
  Carcinogenesis 25
  
  Pages: 1859-1866
- Data Source
  KAKENHI-PROJECT-04J03680
[Journal Article] A novel tumor-derived SGOL1 variant causes abnormal mitosis and unstable chromatid cohesion
- Author(s)
  Kahyo T, Shinmura K, et al.
- Journal Title
  
  Oncogene
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590356
[Journal Article] Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma.
- Author(s)
  Shinmura K, Tao H, Nagura K, Goto M, Matsuura S, Mochizuki T, Suzuki K, Tanahashi M, Niwa H, Ogawa H, Sugimura H
- Journal Title
  
  Lung Cancer (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] EML4-ALK fusion transcripts,but no NPM-,TPM3-,CLTC-,ATIC-,or TFG-ALK fusion transcripts,in non-small cell lung carcinomas
- Author(s)
  Shinmura K, et. al.
- Journal Title
  
  Lung Cancer (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma
- Author(s)
  Shinmura K, et al.
- Journal Title
  
  Lung Cancer (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790286
[Journal Article] Effect of splice-site polymorphisms of the TMPRSS4, NPHP4, and ORCTL4 genes on their mRNA expression.
- Author(s)
  Yamada H., Shinmura K., Sugimura H.et al.
- Journal Title
  
  J.Genet. (In press)
- Data Source
  KAKENHI-PROJECT-04J03680
[Journal Article] Aberrant expression and mutation-inducing activity of AID in human lung cancer
- Author(s)
  Shinmura K, et al.
- Journal Title
  
  Ann Surg Oncol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] ナノスーツ技術を応用した光-電子相関顕微鏡(NanoSuit-CLEM)元素分析によるリン酸ランタン沈着の病理診断2022
- Author(s)
  丸山保彦、新村和也、河崎秀陽、安田和世、松田昌範、鈴木誠、新井一守
- Organizer
  第18回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-20K07445
[Presentation] 基底/筋上皮細胞分化を伴う唾液腺腫瘍におけるprimary ciliaの同定と機能2021
- Author(s)
  新村和也、草深公秀、河崎秀陽、加藤寿美、針山孝彦、土屋一夫、川西祐一、船井和仁、三澤清、峯田周幸、椙村春彦
- Organizer
  第67回日本病理学会秋期特別総会
- Data Source
  KAKENHI-PROJECT-20K07445
[Presentation] WDR62過剰発現は肺腺癌患者の予後不良因子となり、また、肺癌細胞の悪性度を増す2017
- Author(s)
  新村和也, 加藤寿美, 川西祐一, 五十嵐久喜, 井上裕介, 船井和仁, 棚橋雅幸, 丹羽宏, 小川博, 椙村春彦
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-16K08709
[Presentation] SASS6高発現は大腸癌のM期染色体異常と患者予後不良と関連性を示す2015
- Author(s)
  新村和也, 加藤寿美, 川西祐一, 加茂隆春, 井上裕介, 倉部誠也, 杜春平, 倉地清隆, 中村利夫, 椙村春彦.
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-25460476
[Presentation] 日本人若年発症大腸がん患者で見つけられた低8-hydroxyguanine修復・突然変異制御活性を示すMUTYH variant2014
- Author(s)
  新村和也、後藤正憲、陶弘、加藤寿美、中村悟己、松田知成、椙村春彦
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25460476
[Presentation] 酸化的損傷塩基の除去修復因子であるDNAグリコシラーゼの活性の個体差・異常とがん化に関する研究2012
- Author(s)
  新村和也
- Organizer
  第58回(平成24年度)日本病理学会秋期特別総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] 非小細胞肺癌におけるSGOL1発現の臨床的意義2012
- Author(s)
  松浦駿, 新村和也, 華表友暁, 乾直輝, 須田隆文, 椙村春彦, 千田金吾
- Organizer
  第52回日本呼吸器学会学術講演会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] 胃癌におけるMUTYHの8-hydroxyguanine誘発変異抑制活性とその発現レベルの予後予測に関する検討2012
- Author(s)
  新村和也、後藤正憲、鈴木雅也、陶弘、山田英孝、五十嵐久喜、松浦駿、前田松喜、今野弘之、松田知成、椙村春彦
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] 酸化的損傷塩基の除去修復因子であるDNAグリコシラーゼの活性の個体差異常とがん化に関する研究2012
- Author(s)
  新村和也
- Organizer
  第58回日本病理学会秋期特別総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] 胃癌におけるMUTYHの8-hydroxyguanine誘発変異抑制活性とその発現レベルの予後予測に関する検討2012
- Author(s)
  新村和也、後藤正憲、椙村春彦
- Organizer
  第65回日本酸化ストレス学会学術集会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] ヒト肺癌における脱アミノ化酵素AIDの異常発現と変異誘導能2011
- Author(s)
  新村和也、五十嵐久喜、後藤正憲、陶弘、山田英孝、松浦駿、小川博、椙村春彦
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] The activity and localization of 14 MUTYH variant proteins found in patients with colorectal polyposis and cancer2011
- Author(s)
  Goto M, Shinmura K, Nakabeppu Y, Tao H, Yamada H, Tsuneyoshi T, Sugimura H
- Organizer
  70th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] Aberrant expression and mutation-inducing activity of AID in human lung cancer2011
- Author(s)
  Shinmura K
- Organizer
  70th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  名古屋国際会議場(名古屋)
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] ヒト肺癌における脱アミノ化酵素AIDの異常発現と変異誘導能2011
- Author(s)
  新村和也
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  パシフィコ横浜(横浜)
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] 大腸ポリポーシスと大腸がんの患者で見つかった14種のMUTYH変異型タンパク質の活性と局在の評価2011
- Author(s)
  後藤正憲、新村和也、中別府雄作、陶弘、山田英孝、常吉俊宏、椙村春彦
- Organizer
  がん予防大会2011(第18回日本がん予防学会、第34回日本がん疫学分子疫学研究会)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] Aberrant expression and mutation-inducing activity of AID in human lung cancer2011
- Author(s)
  Shinmura K, Igarashi H, Goto M, Tao H, Yamada H, Matsuura S, Matsuda T, Ogawa H, Sugimura H
- Organizer
  70th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] Analysis of a novel shugoshin-like 1 variant from colon cancer2010
- Author(s)
  Kahyo T, Iwaizumi M, Yamada H, Shinmura K, Sugimura H
- Organizer
  69th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] Altered expression and the missensepolymorphism of the human base excision repair gene NTH1 in gastric cancer2010
- Author(s)
  Goto M, Shinmura K, Konno H, Sugimura H
- Organizer
  101th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  101th Annual Meeting of the American Association for Cancer Research
- Data Source
  KAKENHI-PROJECT-22590356
[Presentation] 消化管癌におけるシュゴシン(hSgo1)の病理学的変化と染色体不安定性への関与.2009
- Author(s)
  岩泉守哉、新村和也、森弘樹、山田英孝、北山康彦、伊熊睦博、椙村春彦
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19790286
[Presentation] Altered expression of the human base excision repair gene NTH1 in gastric cancer.2009
- Author(s)
  Goto M, Shinmura K, Igarashi H, Kobayashi M, Konno H, Yamada H, Iwaizumi M, Kageyama S, Tsuneyoshi T, Tsugane S, Sugimura H
- Organizer
  68th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19790286
[Presentation] Production of a novel hSgo1 splicing product is a potential cause of down-regulation of wild type hSgo1 in colorectal cancer.2009
- Author(s)
  Iwaizumi M, Shinmura K, Yamada H, Sugimura H
- Organizer
  100th Annual Meeting of the American Association for Cancer Research.
- Place of Presentation
  Denver
- Data Source
  KAKENHI-PROJECT-19790286
[Presentation] ベンゾピレン代謝産物B[a]PDEを処理したp53欠損肺癌細胞株における中心体過剰複製と染色体不安定性の誘導.2009
- Author(s)
  新村和也、岩泉守哉、鈴木雅也、五十嵐久喜、山田英孝、椙村春彦
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19790286
[Presentation] Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to B[a]PDE2008
- Author(s)
  Shinmura K, et.al.
- Organizer
  67th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19790286
[Presentation] 大腸癌においてヒトSgo1の低下は染色体不安定性を誘導する2008
- Author(s)
  岩泉守哉、新村和也、伊熊睦博、椙村春彦
- Organizer
  第16回浜名湖シンポジウム
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-19790286
[Presentation] Human Sgo1 down-regulation and chromosomal instability in colorectal cancer.2008
- Author(s)
  Iwaizumi M, Shinmura K, Mori H, Yamada H, Kitayama Y, Ikuma M, Sugimura H
- Organizer
  67th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19790286
[Presentation] Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to B[a]PDE.2008
- Author(s)
  Shinmura K, Iwaizumi M, Suzuki M, Sugimura H
- Organizer
  67th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19790286
[Presentation] Human Sgo1 downregulation leads to chromosome instability in human colorectal cancer cells.2007
- Author(s)
  Iwaizumi M, Shinmura K, Mori H, Yamada H, Ikuma M, Sugimura H
- Organizer
  66th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19790286
[Presentation] Identification and characterization of a novel germ line p53 mutation in Japanese familial gastric cancer2007
- Author(s)
  Yamada H, Shinmura K, Okudela K, Goto M, Suzuki M, Kuriki K, Tsuneyoshi T, Sugimura H
- Organizer
  66th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19790286
[Presentation] 日本人若年発症大腸がん患者で見つけられた低8-hydroxyguanine修復・突然変異制御活性を示すMUTYH variant
- Author(s)
  新村和也, 後藤正憲, 後藤正憲, 陶弘, 加藤寿美, 中村悟己, 松田知成, 椙村春彦
- Organizer
  第67回日本酸化ストレス学会学術集会
- Place of Presentation
  同志社大学　京都府京都市
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-25460476
[Presentation] SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers
- Author(s)
  Matsuura S, Kahyo T, Shinmura K, Iwaizumi M, Yamada H, Funai K, Niwa H, Takahashi T, Suda T, Watanabe Y, Sugimura H
- Organizer
  73th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  パシフィコ横浜　神奈川県横浜市
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460476

1. MIURA Naoyuki (40165965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. UEZATO Tadayoshi (40115465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 河崎秀陽 (90397381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 瀬藤光利 (20302664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 針山孝彦 (30165039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 椙村春彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 松田知成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 中村卓郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 中村祐輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 山田泰広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 加藤秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 中村直哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 高橋隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shinmura Kazuya 新村 和也

新村 和也 シンムラ カズヤ

SHINMURA Kazuya 新村 和也

Research Projects

Research Products

Co-Researchers

新規組織型群である一次繊毛陽性腫瘍の病理学的病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of Multimodal Translational Pathology Using NanoSuit-Scanning Electron Microscopy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel tumor morphological features on HE-stained slides by electron microscopy observation using the NanoSuit methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characteristics of human cancers showing high-level centrosome amplification and their sensitivity to drugs targeting centrosome amplificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the mechanism underlying the centrosome amplification induced by DNA repair abnormality in cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the abnormal centrosome regulation, leading to the chromosome instability in cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of mice in which the mouse hepatocytes are replaced with the human hepaocytes and its application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the abnormal centrosome regulation, leading to the chromosome instability in cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胃悪性リンパ腫および胃がんの感受性因子に関する分子病理学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト塩基除去修復酵素の遺伝子多型に基づく活性の個体差に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト塩基除去修復酵素の遺伝子多型に基づく活性の個体差に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Centrosome Abnormality and Human Lung Cancer in Lung Diseases - Selected State of the Art Reviews2012

Author(s)

Total Pages

Publisher

Data Source

[Book] Centrosome Abnormality and Human Lung Cancer in Lung Diseases - Selected State of the Art Reviews、Irusen EM (Ed.)2012

Author(s)

Publisher

Shinmura Kazuya 新村和也

新村和也シンムラカズヤ

SHINMURA Kazuya 新村和也