Nishimura Masaki 西村正樹

… Alternative Names

NISHIMURA Masaki 西村正樹

西村正樹ニシムラマサキ

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Researcher Number	40322739
Other IDs
External Links
Affiliation (Current)	2025: 滋賀医科大学, 神経難病研究センター, 客員教授
Affiliation (based on the past Project Information) *help	2024: 滋賀医科大学, 神経難病研究センター, 客員教授 2019 – 2023: 滋賀医科大学, 神経難病研究センター, 教授 2016: 滋賀医科大学, 神経難病研究センター, 教授 2014 – 2015: 滋賀医科大学, 分子神経科学研究センター, 教授 2013: 滋賀医科大学, 分子神経科学研究センタ-, 准教授 … More 2011 – 2013: 滋賀医科大学, 分子神経科学研究センター, 准教授 2007: Shiga University of Medical Science, 分子神経科学研究センター, 准教授 2006: 滋賀医科大学, 分子神経科学研究センター, 助教授 2000 – 2004: 滋賀医科大学, 分子神経科学研究センター, 助教授 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 51030:Pathophysiologic neuroscience-related / Studies on the Super-Aging Society / Pathological medical chemistry / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology Except Principal Investigator Medium-sized Section 58:Society medicine, nursing, and related fields / Pathological medical chemistry / Laboratory animal science / Functional biochemistry
Keywords	Principal Investigator アルツハイマー病 / アミロイドβ / γセクレターゼ / βアミロイド / プレセニリン / Presenilin / ニカストリン / 先制医療 / 老化 / γ-secretase … More / Nicastrin / 認知症 / FAM3C / ILEI / 予防的介入 / 遺伝子発現制御 / APP / ゲノム編集 / リスク遺伝子 / 老年期認知症 / 加齢 / リスク因子 / 並体結合 / 脳 / 循環因子 / Amyloidβ / Alzheimer's disease / β-amyloid / Alzheimer disease / γセレクターゼ / 神経変性疾患 / 神経科学 / シナプス / トランスジェニック・マウス / 神経疾患 / CRB2 … More Except Principal Investigator 認知症 / アミロイドβ / アルツハイマー病 / γセクレターゼ / 日本人一般住民 / 潜在性動脈硬化 / 疫学 / AI / MRI / βアミロイド / セクレターゼ / アミロイド蛋白 / 治療 / 調節蛋白 / アミロイドβ蛋白 / 疾患モデル / 霊長類 / AAVベクター / カニクイザル / アデノ随伴ウイルス / タンパク質分秋 / 細胞応答 / sシグナル伝達 / RIP Less

老化関連因子が脳Aβ蓄積を促進する分子メカニズムの解析Principal Investigator
- Principal Investigator
  
  西村正樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
認知症予測の網羅的モデル開発のための一般集団における脳画像長期追跡疫学研究
- Principal Investigator
  
  三浦克之
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Shiga University of Medical Science
Identification of circulating factors triggering molecular pathological processes of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Nishimura Masaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Studies on the Super-Aging Society
- Research Institution
  Shiga University of Medical Science
Development of preventive therapy for Alzheimer's disease by modification in expressional levels of the risk genesPrincipal Investigator
- Principal Investigator
  
  Nishimura Masaki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
Neuron-specific mechanism for production and secretion of amyloid-beta and therapeutic regulation of its depositionPrincipal Investigator
- Principal Investigator
  
  NISHIMURA Masaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Model animals by nonhuman primate for Alzheimer disease, hyper expression of mutant amyloid precursor protein and formation of senile plaques in the brain
- Principal Investigator
  
  NAKAMURA Shinichiro
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Shiga University of Medical Science
Development of therapeutic strategy for Alzheimer's disease by targeting amyloid precursor protein C99Principal Investigator
- Principal Investigator
  
  NISHIMURA Masaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Functional analysis of the novel modulator of gamma secretase
- Principal Investigator
  
  HASEGAWA Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shiga University of Medical Science
長鎖アミロイドβ生成の調節メカニズム解明とその抑制法開発Principal Investigator
- Principal Investigator
  
  西村正樹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
RIPによる細胞内情報伝達機構
- Principal Investigator
  
  鈴木利治
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Clarification of the mechanism underlying y-secretase cleavage by presenilin complexesPrincipal Investigator
- Principal Investigator
  
  NISHIMURA Masaki
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
Clarification of Molecular Mechanism For-AmyloidβGeneration in Alzheimer's DiseasePrincipal Investigator
- Principal Investigator
  
  NISHIMURA Masaki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shiga University of Medical Science
アルツハイマー病プレセニリン複合体の構成蛋白同定と機能解析に関する研究Principal Investigator
- Principal Investigator
  
  西村正樹
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science

[Book] The Neuroscience of Dementia2020
- Author(s)
  Nishimura M, Watanabe N, Mitsuishi Y, Hibino E, Nakano M, Liu L, Sugi T
- Publisher
  Elsevier
- ISBN
  9780128160435
- Data Source
  KAKENHI-PROJECT-19K21585
[Book] タンパク質発現解析-免疫組織化学法に法補的な手法-. 「組織細胞化学2014」2014
- Author(s)
  西村正樹
- Publisher
  日本組織細胞化学会(印刷中)
- Data Source
  KAKENHI-PROJECT-23500445
[Book] 日本臨床増刊号認知症学(上)-その解明と治療の最新知見-2011
- Author(s)
  西村正樹. Nicastrin
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-23500445
[Journal Article] Brain <scp>p3‐Alcβ</scp> peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide2023
- Author(s)
  Hata S, Saito H, Kakiuchi T, Fukumoto D, Yamamoto S, Kasuga K, Kimura A, Moteki K, Abe R, Adachi S, Kinoshita S, Yoshizawa-Kumagaye K, Nishio H, Saito T, Saido TC, Yamamoto T, Nishimura M, Taru H, Sobu Y, Ohba H, Nishiyama S, Harada N, Ikeuchi T, Tsukada H, Ouchi Y, Suzuki T
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: - Issue: 5 Pages: 1-15
- DOI
  10.15252/emmm.202217052
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0143, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-20H03600, KAKENHI-PROJECT-22K06597, KAKENHI-PROJECT-23K06840, KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-22K15270, KAKENHI-PROJECT-23K26790
[Journal Article] Human FAM3C restores memory-based thermotaxis of Caenorhabditis elegans famp-1/m70.4 loss-of-function mutants.2022
- Author(s)
  Nakano M, Imamura R, Sugi T, Nishimura M.
- Journal Title
  
  PNAS Nexus
  
  Volume: 1 Issue: 5 Pages: 1-11
- DOI
  10.1093/pnasnexus/pgac242
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03546
[Journal Article] Transcriptional downregulation of FAM3C/ILEI in the Alzheimer’s brain.2022
- Author(s)
  Watanabe N, Nakano M, Mitsuishi Y, Hara N, Mano T, Iwata A, Murayama S, Suzuki T, Ikeuchi T, Nishimura M
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 31 Issue: 1 Pages: 122-132
- DOI
  10.1093/hmg/ddab226
- NAID
  120007186913
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19K16912, KAKENHI-PROJECT-19K17027, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-20H03587, KAKENHI-PROJECT-20K16491, KAKENHI-PROJECT-16H06277
[Journal Article] Bex1 is essential for ciliogenesis and harbours biomolecular condensate-forming capacity2022
- Author(s)
  Hibino Emi、Ichiyama Yusuke、Tsukamura Atsushi、Senju Yosuke、Morimune Takao、Ohji Masahito、Maruo Yoshihiro、Nishimura Masaki、Mori Masaki
- Journal Title
  
  BMC Biology
  
  Volume: 20 Issue: 1 Pages: 1-21
- DOI
  10.1186/s12915-022-01246-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07788, KAKENHI-PROJECT-22K19499, KAKENHI-PUBLICLY-22H05643, KAKENHI-PROJECT-19H03546
[Journal Article] Extracellular release of ILEI/FAM3C and amyloid-β is associated with the activation of distinct synapse subpopulations.2021
- Author(s)
  Nakano M, Mitsuishi Y, Liu L, Watanabe N, Hibino E, Hata S, Saito T, Saido C T, Murayama S, Kasuga K, Ikeuchi K, Suzuki T, Nishimura M
- Journal Title
  
  Journal of Alzheimer’s disease
  
  Volume: 80 Issue: 1 Pages: 159-174
- DOI
  10.3233/jad-201174
- NAID
  120007019774
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16912, KAKENHI-PROJECT-20K16491, KAKENHI-PROJECT-18H02566, KAKENHI-PROJECT-18K07384, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546
[Journal Article] A Potential Defense Mechanism Against Amyloid Deposition in Cerebellum2021
- Author(s)
  Shahnur Alam, Masaki Nakano, Seiko Ishihara, Nobuto Kakuda, Tomohiro Miyasaka, Hina Uchiyama, Yuuna Shirai, Mohammad Moniruzzaman, Takashi Saito, Takaomi C. Saido, Masaki Nishimura, Satoru Funamoto
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 535 Pages: 25-32
- DOI
  10.1016/j.bbrc.2020.12.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16912, KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546
[Journal Article] Gm14230 controls Tbc1d24-cytoophidia and neuronal cellular juvenescence2021
- Author(s)
  Morimune T, Tano A, Tanaka Y, Yukiue H, Yamamoto T, Maruo Y, Nishimura M, Tooyama I, Mori M
- Journal Title
  
  PLoS ONE
  
  Volume: 16 Issue: 4 Pages: 1-14
- DOI
  10.1371/journal.pone.0248517
- NAID
  120007034814
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PUBLICLY-19H04774, KAKENHI-PROJECT-18K07788, KAKENHI-PROJECT-18K07818, KAKENHI-PROJECT-19H03546
[Journal Article] Neuroepithelial cell competition triggers loss of cellular juvenescence2020
- Author(s)
  Jam Faidruz Azura、Morimune Takao、Tsukamura Atsushi、Tano Ayami、Tanaka Yuya、Mori Yasuhiro、Yamamoto Takefumi、Nishimura Masaki、Tooyama Ikuo、Mori Masaki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-21
- DOI
  10.1038/s41598-020-74874-4
- NAID
  120006901557
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07788, KAKENHI-PROJECT-19K21585, KAKENHI-PUBLICLY-19H04774, KAKENHI-PROJECT-19H03546
[Journal Article] Enhanced amyloid-β generation by γ-secretase complex in detergent-resistant membrane microdomains with reduced cholesterol levels2020
- Author(s)
  Hata S, Hu A, Piao Y, Nakaya T, Taru H, Morishima-Kawashima M, Murayama S, Nishimura M, Suzuki T.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 29 Issue: 3 Pages: 382-393
- DOI
  10.1093/hmg/ddz297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PUBLICLY-18H04851, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18H02566, KAKENHI-PROJECT-18K07384
[Journal Article] Generation of transgenic cynomolgus monkeys overexpressing the gene for amyloid-β precursor protein2020
- Author(s)
  Seita Y, Morimura T, Watanabe N, Iwatani C, Tsuchiya H, Nakamura S, Suzuki T, Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: - Issue: 1 Pages: 45-60
- DOI
  10.3233/jad-191081
- NAID
  120006859791
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17K08077, KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-17K17812, KAKENHI-PROJECT-20K21370, KAKENHI-PROJECT-19K16023, KAKENHI-PROJECT-20K16491, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-18H02566
[Journal Article] Decrease in p3‐Alcβ37 and p3‐Alcβ40, products of Alcadein β generated by γ‐secretase cleavages, in aged monkeys and patients with Alzheimer's disease2019
- Author(s)
  Hata S、Omori C、Kimura A、Saito H、Kimura N、Gupta V、Pedrini S、Hone E、Chatterjee P、Taddei K、Kasuga K、Ikeuchi T、Waragai M、Nishimura M、Hu A、Nakaya T、Meijer L、Maeda M、Yamamoto T、Masters CL、Rowe CC、Ames D、Yamamoto K、Martins RN、Gandy S、Suzuki T
- Journal Title
  
  Alzheimer's & Dementia: Translational Research & Clinical Interventions
  
  Volume: 5 Issue: 1 Pages: 740-750
- DOI
  10.1016/j.trci.2019.09.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07384, KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-19K21585, KAKENHI-PUBLICLY-18H04851, KAKENHI-PROJECT-17H03574, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-16K08237, KAKENHI-PROJECT-18H02566
[Journal Article] Lipid class composition of membrane and raft fractions from brains of individuals with Alzheimer's disease2019
- Author(s)
  Kawatsuki A, Morita S-Y, Watanabe N, Hibino E, Mitsuishi Y, Sugi T, Murayama S, Nishimura M.
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 20 Pages: 100704-100704
- DOI
  10.1016/j.bbrep.2019.100704
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-17K17812, KAKENHI-PROJECT-16H06277
[Journal Article] 新規内在性γセクレターゼ結合因子ILEI/FAM3Cによるアミロイドβ産生制御2017
- Author(s)
  西村正樹
- Journal Title
  
  実験医学『認知症研究の新時代』
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-26430070
[Journal Article] アミロイドβ産生を抑制する分泌型タンパク質ILEI/FAM3Cによるアルツハイマー病の次世代診断・治療2017
- Author(s)
  西村正樹
- Journal Title
  
  分子精神医学
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-26430070
[Journal Article] Immunohistochemical detection of the delayed formation of non-fibrillar large amyloid-β aggregates.2016
- Author(s)
  Ochiishi T, Itakura A, Liu L, Akatsu H, Kohno H, Nishimura M, Yoshimune K
- Journal Title
  
  Genes to Cells
  
  Volume: 21 Issue: 2 Pages: 200-211
- DOI
  10.1111/gtc.12332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430070
[Journal Article] 抗認知症薬剤開発の現状と展望2016
- Author(s)
  西村正樹
- Journal Title
  
  総合リハビリテーション
  
  Volume: 44 Pages: 29-34
- Data Source
  KAKENHI-PROJECT-26430070
[Journal Article] Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body2016
- Author(s)
  Seita Y, Tsukiyama T, Iwatani C, Tsuchiya H, Matsushita J, Azami T, Okahara J, Nakamura S, Hayashi Y, Hitoshi S, Itoh Y, Imamura T, Nishimura M, Tooyama I, Miyoshi H, Saitou M, Ogasawara K, Sasaki E, Ema M
- Journal Title
  
  Scientific Reports
  
  Volume: 2 Issue: 1 Pages: 24868-24868
- DOI
  10.1038/srep24868
- NAID
  130007023590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26640053, KAKENHI-PROJECT-15K21080, KAKENHI-PROJECT-16H04671, KAKENHI-PROJECT-26430070, KAKENHI-PROJECT-26870282, KAKENHI-PROJECT-16K14578
[Journal Article] Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.2016
- Author(s)
  Liu L, Watanabe N, Akatsu H, Nishimura M.
- Journal Title
  
  Neuroscience
  
  Volume: 330 Pages: 236-246
- DOI
  10.1016/j.neuroscience.2016.05.050
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430070, KAKENHI-PROJECT-15K18375
[Journal Article] Presynaptic localization of the γ-secretase-inhibiting protein p24α2 in the mammalian brain.2015
- Author(s)
  Liu L, Fujino K, Nishimura M
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 133 Issue: 3 Pages: 422-431
- DOI
  10.1111/jnc.13000
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430070, KAKENHI-PROJECT-15K18375
[Journal Article] The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-beta precursor.2014
- Author(s)
  Hasegawa, H., L. Liu, I. Tooyama, S. Murayama and M. Nishimura
- Journal Title
  
  Nat Commun
  
  Volume: 5 Issue: 1 Pages: 3917-3917
- DOI
  10.1038/ncomms4917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23300155, KAKENHI-PROJECT-23500445, KAKENHI-PROJECT-23590359, KAKENHI-PROJECT-26430070
[Journal Article] OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.2014
- Author(s)
  Han J, Jung S, Jang J, Kam TI, Choi H, Kim BJ, Nah J, Jo DG, Nakagawa T, Nishimura M, Jung YK.
- Journal Title
  
  Cellular and Molecular Life Sciences
  
  Volume: 未定 Issue: 13 Pages: 2561-2576
- DOI
  10.1007/s00018-013-1515-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500445, KAKENHI-PROJECT-26500006
[Journal Article] Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue2012
- Author(s)
  Matsushima T
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 23 Pages: 19715-19724
- DOI
  10.1074/jbc.m111.334847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240039, KAKENHI-PROJECT-22590055, KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23500445, KAKENHI-PROJECT-23790069, KAKENHI-PROJECT-24790062, KAKENHI-PUBLICLY-23113701
[Journal Article] Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Abeta generation in Alzheimer's disease2012
- Author(s)
  Saito Y
- Journal Title
  
  Mol Neurodegener
  
  Volume: 7 Issue: 1 Pages: 50-50
- DOI
  10.1186/1750-1326-7-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240039, KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-22390224, KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23500445, KAKENHI-PROJECT-23659564, KAKENHI-PROJECT-23790069, KAKENHI-PROJECT-24300133, KAKENHI-PUBLICLY-23113701
[Journal Article] γセクレターゼ複合体に作用しAβ産生を制御する内在性タンパク質2012
- Author(s)
  西村正樹
- Journal Title
  
  Dementia Japan
  
  Volume: 26(1) Pages: 44-50
- Data Source
  KAKENHI-PROJECT-23500445
[Journal Article] Age-related modulation of γ-secretase activity in non-human primate brains2012
- Author(s)
  Nishimura M, Nakamura S, Kimura N, Liu L, Suzuki T, Tooyama I
- Journal Title
  
  J Neurochem
  
  Volume: 123(1) Pages: 21-28
- NAID
  120005713696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500445
[Journal Article] Age-related modulation of γ-secretase activity in non-human primate brains2012
- Author(s)
  Nishimura M
- Journal Title
  
  J Neurochem
  
  Volume: 123 Issue: 1 Pages: 21-28
- DOI
  10.1111/j.1471-4159.2012.07884.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240039, KAKENHI-PROJECT-23300155, KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23500445, KAKENHI-PUBLICLY-23113701
[Journal Article] Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr^<668> residue2012
- Author(s)
  Matsushima T, Saito Y, Elliott JI, Iijima-Ando K, Nishimura M, Kimura N, Hata S, Yamamoto T, Nakaya T, Suzuki T
- Journal Title
  
  J Biol Chem
  
  Volume: 287(23) Pages: 19715-19724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500445
[Journal Article] γセクレターゼ複合体に作用しAβ産生を制御する内在性タンパク質2012
- Author(s)
  西村正樹
- Journal Title
  
  Dementia Japan
  
  Volume: 26(1) Pages: 44-50
- Data Source
  KAKENHI-PROJECT-23300155
[Journal Article] Hyperpolarization-activated cyclic nucleotide gated channels : a potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease2012
- Author(s)
  Saito Y, Inoue T, Zhu G, Kimura N, Okada M, Nishimura M, Kimura N, Murayama S, Kaneko S, Shigemoto R, Imoto1 K, Suzuki T
- Journal Title
  
  Mol Neurodegener
  
  Volume: 7 Pages: 50-50
- NAID
  120005133364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500445
[Journal Article] Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease : Evidence for γ-secretase dysfunction2011
- Author(s)
  Hata S, Fujishige S, Araki Y, Taniguchi M, Urakami K, Peskind E, Akatsu H, Araseki M, Yamamoto K, Martins RN, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, Leverenz J, Fagan A, Goate A, Bateman R, Holtzman DM, Yamamoto T, Nakaya N, Gandy S, Suzuki T
- Journal Title
  
  Ann Neurol
  
  Volume: 69(6) Pages: 1026-1031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500445
[Journal Article] Potent amyloidogenicity and pathogenicity of Aβ432011
- Author(s)
  Takashi Saito, Takahiro Suemoto, Nathalie Brouwers, Kristel Sleegers, Satoru Funamoto, Naomi Mihira, Yukio Matsuba, Kazuyuki Yamada, Per Nilsson, Jiro Takano, Masaki Nishimura, Nobuhisa Iwata, Christine Van Broeckhoven, Yasuo Ihara, Takaomi C Saido
- Journal Title
  
  Nature Neuroscience
  
  Volume: 14 Issue: 8 Pages: 1023-1032
- DOI
  10.1038/nn.2858
- NAID
  120006985066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379, KAKENHI-PROJECT-23300155, KAKENHI-PROJECT-23500445, KAKENHI-PROJECT-23680039
[Journal Article] Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease : evidence for γ-secretase dysfunction2011
- Author(s)
  Hata S
- Journal Title
  
  Ann.Neurol.
  
  Volume: 69 Issue: 6 Pages: 1026-1031
- DOI
  10.1002/ana.22343
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590055, KAKENHI-PROJECT-22659011, KAKENHI-PROJECT-22890001, KAKENHI-PUBLICLY-23113701, KAKENHI-PROJECT-23300155, KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23500445
[Journal Article] Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter2011
- Author(s)
  Matsuo A, Bellier JP, Nishimura M, Yasuhara O, Saito N, Kimura H
- Journal Title
  
  J Biol Chem
  
  Volume: 286(7) Pages: 5836-5845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500445
[Journal Article] アルツハイマー病に対するメマンチン治療2011
- Author(s)
  西村正樹
- Journal Title
  
  医事新報
  
  Volume: 4537 Pages: 62-63
- Data Source
  KAKENHI-PROJECT-23500445
[Journal Article] Potent amyloidogenicity and pathogenicity of Aβ432011
- Author(s)
  Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC
- Journal Title
  
  Nat Neurosci
  
  Volume: 14(8) Pages: 1023-1032
- NAID
  120006985066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500445
[Journal Article] Regulated Intramembrane Proteolysisとγセクレクーゼ2008
- Author(s)
  西村正樹
- Journal Title
  
  Cognition and Dementia 7・1
  
  Pages: 14-22
- Data Source
  KAKENHI-PROJECT-18023019
[Journal Article] 家族性アルツハイマー病の原因遺伝子プレセニリン2008
- Author(s)
  西村正樹
- Journal Title
  
  日本臨床増刊号
  
  Pages: 144-149
- Data Source
  KAKENHI-PROJECT-18023019
[Journal Article] Random mutagenesis of presenilin 1 identifies novel mutants exclusively generating long amyloid β peptides.2005
- Author(s)
  Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, Nishimura M.
- Journal Title
  
  J Biol Chem 280(19)
  
  Pages: 19070-19077
- NAID
  120005713693
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2.2005
- Author(s)
  Wang HQ, Nakaya Y, Du Z, Yamane T, Shirane M, Kudo T, Takeda M, Takebayashi K, Noda Y, Nakayama KI, Nishimura M.
- Journal Title
  
  Hum Mol Genet 14(13)
  
  Pages: 1889-1902
- NAID
  120005713692
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] β-and γ-secretases as therapeutic targets for Alzheimer's disease.2004
- Author(s)
  Nishimura M.
- Journal Title
  
  Igaku no Ayumi 208(5)
  
  Pages: 443-448
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] Alzheimer病 : Aβの生成抑制による治療戦略2004
- Author(s)
  西村正樹
- Journal Title
  
  最新医学 59・7
  
  Pages: 1574-1580
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] PEN-2 enhances y-cleavage after presenilin heterodimer formation.2004
- Author(s)
  Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, Yanagisawa K, Komano H.
- Journal Title
  
  J Neurochem 90(6)
  
  Pages: 1402-1413
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] Alzheimer病:Aβの生成抑制による治療戦略2004
- Author(s)
  西村正樹
- Journal Title
  
  最新医学 59・7
  
  Pages: 1574-1580
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] Coordinated metabolism of Alcadein and amyloid β-protein precursor regulates FE65-dependent gene transactivation.2004
- Author(s)
  Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T.
- Journal Title
  
  J Biol Chem 279(23)
  
  Pages: 24343-24354
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] βおよびγセクレターゼを標的としたAlzheimer病の分子治療2004
- Author(s)
  西村正樹
- Journal Title
  
  医学のあゆみ 208・5
  
  Pages: 443-448
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] Therapeutric strategy for Alzheimer disease : Inhibition of Amyloid β generation.2004
- Author(s)
  Nishimura M.
- Journal Title
  
  Saishin Igaku 59(7)
  
  Pages: 1574-1580
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] Aβの産生とその調節メカニズム2004
- Author(s)
  西村正樹
- Journal Title
  
  Molecular Medicine 41・4
  
  Pages: 409-415
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] New therapy for Alzheimer disease by inhibition of amyloid p production.2004
- Author(s)
  Nishimura M, eds.Kanazawa I, Shibasaki H, Tohgi H.
- Journal Title
  
  Advanced Medicine in Neurology 348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] Generation of Amyloid β and its regulatory mechanism.2004
- Author(s)
  Nishimura M.
- Journal Title
  
  Mol Med (Japan) 41(4)
  
  Pages: 409-415
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] Follistatin-related gene (FLRG) expression in human endometrium : sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells.2003
- Author(s)
  Wang HQ, Takebayashi K, Tsuchida K, Nishimura M, Noda Y.
- Journal Title
  
  J Clin Endocrinol Metab 88(9)
  
  Pages: 4432-4439
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] Normal brain development in PS1 hypomorphic mice with markedly reduced y-secretase cleavage of βAPP.2002
- Author(s)
  Rozmahel R, Huang J, Chen F, Liang Y, Nguyen V, Ikeda M, Levesque G, Yu G, Nishimura M, Mathews P, Schmidt SD, Mercken M, Bergeron C, Westaway D, St George-Hyslop P.
- Journal Title
  
  Neurobiol Aging 23(2)
  
  Pages: 187-194
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] Nicastrin binds to membrane-tethered Notch.2001
- Author(s)
  Chen F, Yu G, Arawaka S, Nishimura M, Kawarai T, Yu H, Tandon A, Supala A, Song YQ, Rogaeva E, Milman P, Sato C, Yu C, Janus C, Lee J, Song L, Zhang L, Fraser PE, St George-Hyslop PH.
- Journal Title
  
  Nature Cell Biol 3(8)
  
  Pages: 751-754
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] Presenilin-nicastrin complexes and γ-secretase in Alzheimer's disease.2001
- Author(s)
  Nishimura M.
- Journal Title
  
  Igaku no Ayumi 198(5)
  
  Pages: 369-372
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] Presenilin function : connections to Alzheimer's disease and signal transduction.2001
- Author(s)
  Fraser PE, Yu G, Levesque L, Nishimura M, Yang DS, Mount HT, Westaway D, St George-Hyslop PH.
- Journal Title
  
  Biochem Soc Symp (67)
  
  Pages: 89-100
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Journal Article] アルツハイマー病プレセニリン-ニカストリン複合体とγセクレターゼ2001
- Author(s)
  西村正樹
- Journal Title
  
  医学のあゆみ 198・5
  
  Pages: 369-372
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210067
[Patent] アミロイドβタンパク質が異常に蓄積する疾患の治療及び/又は予防用の医薬組成物2013
- Inventor(s)
  西村正樹
- Industrial Property Rights Holder
  滋賀医科大学
- Filing Date
  2013-12-13
- Overseas
- Data Source
  KAKENHI-PROJECT-23500445
[Patent] アミロイドβタンパク質が異常に蓄積する疾患の治療及び／又は予防用の医薬組成物2013
- Inventor(s)
  西村正樹
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-12-13
- Overseas
- Data Source
  KAKENHI-PROJECT-23500445
[Patent] アミロイドβタンパク質が異常に蓄積する疾患の治療及び／又は予防用の医薬組成物2012
- Inventor(s)
  西村正樹
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-277068
- Filing Date
  2012-12-19
- Data Source
  KAKENHI-PROJECT-23500445
[Patent] アミロイドβタンパク質が異常に蓄積する疾患の治療及び/又は予防用の医薬組成物2012
- Inventor(s)
  西村正樹
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Number
  2012-277068
- Filing Date
  2012-12-19
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] PresenilinによるAβ産生のデュアル制御メカニズム2022
- Author(s)
  西村正樹,渡邊直希,中野将希
- Organizer
  第41回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] ニコチン受容体活性化のAPP代謝に与える影響2022
- Author(s)
  中野将希、三ツ石弥千代、斉藤貴志、西道隆臣、西村正樹
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] 新規Aβ産生抑制分子ILEIの発現低下によるアルツハイマー病リスクの検証2022
- Author(s)
  渡邊直希,中野将希.西村正樹
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Aβ代謝に与えるニコチン性アセチルコリン受容体活性化の影響2022
- Author(s)
  中野将希,斉藤貴志,西道隆臣,西村正樹
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Extracellular release of ILEI/FAM3C and Aβ is associated with the activation of distinct synapse subpopulation.2021
- Author(s)
  Nakano M, Mitsuishi Y, Liu L, Watanabe N, Saito T, Saido TC, Suzuki T, Nishimura M
- Organizer
  AAIC 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21585
[Presentation] Aβ産生抑制分子ILEI/FAM3Cの発現制御機構2021
- Author(s)
  渡邊直希、村山繁雄、西村正樹
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Extracellular release of ILEI/FAM3C and Aβ is associated with the activation of distinct synapse subpopulation.2021
- Author(s)
  Nakano M, Mitsuishi Y, Liu L, Watanabe N, Saito T, Saido TC, Suzuki T, Nishimura M
- Organizer
  AAIC 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Aβ産生抑制分子ILEI/FAM3Cの発現制御機構2021
- Author(s)
  渡邊直希、村山繁雄、西村正樹
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K21585
[Presentation] ニコチン性アセチルコリン受容体刺激がAβ産生に与える影響2021
- Author(s)
  中野将希、斉藤貴志、西道隆臣、西村正樹．
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K21585
[Presentation] ニコチン性アセチルコリン受容体刺激がAβ産生に与える影響2021
- Author(s)
  中野将希、斉藤貴志、西道隆臣、西村正樹．
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Aβ産生を抑制するFAM3C/ILEIは線虫において記憶学習に関連する2020
- Author(s)
  中野将希、杉拓磨、西村正樹
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] なぜAβ沈着は大脳で多く小脳で少ないのか？―小脳からの盛んなAβ排出ー2020
- Author(s)
  Alam Shahnur、中野将希、石原聖子、宮坂知宏、角田伸人、斉藤貴志、西道隆臣、西村正樹、舟本　聡
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K21585
[Presentation] なぜAβ沈着は大脳で多く小脳で少ないのか？―小脳からの盛んなAβ排出ー2020
- Author(s)
  Alam Shahnur、中野将希、石原聖子、宮坂知宏、角田伸人、斉藤貴志、西道隆臣、西村正樹、舟本　聡
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Extracellular release of ILEI/FAM3C and Aβ is associated with the activation of distinct synapse subpopulation2020
- Author(s)
  Nakano M, Mitsuishi Y, Watanabe N, Saito T, Saido TC, Suzuki T, Nishimura M
- Organizer
  AAIC 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21585
[Presentation] アルツハイマー脳におけるラフトの脂質変化とγセクレターゼの局在・機能変化2020
- Author(s)
  羽田沙緒里、胡安琪、村山繁雄、森島真帆、西村正樹、鈴木利治
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Extracellular release of ILEI/FAM3C and Aβ is associated with the activation of distinct synapse subpopulation.2020
- Author(s)
  Nakano M, Mitsuishi Y, Watanabe N, Saito T, Saido TC, Suzuki T, Nishimura M
- Organizer
  AAIC 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] β産生を抑制するILEI/FAM3Cの転写制御メカニズム解析2020
- Author(s)
  渡邊直希、中野将希、西村正樹
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K21585
[Presentation] Aβ産生を抑制するILEI/FAM3Cの転写制御メカニズム解析2020
- Author(s)
  渡邊直希、中野将希、西村正樹
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Aβ産生を抑制するFAM3C/ILEIは線虫において記憶学習に関連する2020
- Author(s)
  中野将希、杉拓磨、西村正樹
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K21585
[Presentation] アルツハイマー脳におけるラフトの脂質変化とγセクレターゼの局在・機能変化2020
- Author(s)
  羽田沙緒里、胡安琪、村山繁雄、森島真帆、西村正樹、鈴木利治
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K21585
[Presentation] Synaptic activity-dependent release of presynaptic ILEI/FAM3C.2019
- Author(s)
  Nakano M, Mitsuishi Y, Watanabe N, Hibino E, Saito T, Saido TC, Suzuki T, Nishimura M.
- Organizer
  AAIC 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21585
[Presentation] 大脳皮質におけるILEI/FAM3CおよびAβの間質液への分泌様式に関する比較検討2019
- Author(s)
  中野将希, 三ツ石弥千代, 渡邊直希, 日比野絵美, 斉藤貴志, 西道隆臣, 鈴木利治, 西村正樹
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] 大脳皮質におけるILEI/FAM3CおよびAβの間質液への分泌様式に関する比較検討2019
- Author(s)
  中野将希, 三ツ石弥千代, 渡邊直希, 日比野絵美, 斉藤貴志, 西道隆臣, 鈴木利治, 西村正樹
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K21585
[Presentation] 脳Aβ産生の制御にはたらく分子の探索と解析2019
- Author(s)
  西村正樹
- Organizer
  第46回日本脳科学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K21585
[Presentation] 脳Aβ産生の制御にはたらく分子の探索と解析2019
- Author(s)
  西村正樹
- Organizer
  第46回日本脳科学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Presynaptic ILEI/FAM3C is released in an activity-dependent manner like Aβ exocytosis2019
- Author(s)
  中野将希、三ツ石弥千代、渡邊直希、日比野絵美、杉拓磨、斉藤貴志、西道隆臣、鈴木利治、西村正樹
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Synaptic activity-dependent release of presynaptic ILEI/FAM3C2019
- Author(s)
  Nakano M, Mitsuishi Y, Watanabe N, Hibino E, Saito T, Saido TC, Suzuki T, Nishimura M.
- Organizer
  AAIC 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Presynaptic ILEI/FAM3C is released in an activity-dependent manner like Aβ exocytosis2019
- Author(s)
  中野将希、三ツ石弥千代、渡邊直希、日比野絵美、杉拓磨、斉藤貴志、西道隆臣、鈴木利治、西村正樹
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-19K21585
[Presentation] ILEI in the pathogenesis of Alzheimer’s disease.2017
- Author(s)
  Nishimura M.
- Organizer
  Niigata University Brin Institute International Symposium
- Place of Presentation
  Niigata
- Year and Date
  2017-03-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430070
[Presentation] γセクレターゼ複合体の結合タンパク質解析．2016
- Author(s)
  西村正樹
- Organizer
  第21回病態プロテアーゼ学会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-26430070
[Presentation] Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.2016
- Author(s)
  Nishimura M, Liu L, Watanabe N, Akatsu H.
- Organizer
  Alzheimer’s Association International Conference 2016
- Place of Presentation
  Toronto
- Year and Date
  2016-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430070
[Presentation] Brain distribution and subcellular localization of ILEI/FAM3C and its reduction with aging.2016
- Author(s)
  Watanabe N, Liu L, Nishimura M.
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26430070
[Presentation] Amyloid‐β蓄積を抑制するILEI/FAM3Cのニューロンにおける発現とアルツハイマー病脳における発現低下2016
- Author(s)
  渡邊直希, 劉磊, 赤津裕康, 西村正樹.
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26430070
[Presentation] Aβ産生抑制タンパク質ILEI/FAM3Cの脳内発現様式と加齢に伴う発現減少2016
- Author(s)
  渡邊直希, 劉磊, 赤津裕康, 西村正樹.
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26430070
[Presentation] Aβ産生を抑制するタンパク質ILEIの哺乳類脳内発現．2015
- Author(s)
  劉　磊、村山繁雄、西村正樹
- Organizer
  第34回日本認知症学会
- Place of Presentation
  青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26430070
[Presentation] Aβ generation is regulated by p24α2 at the presynaptic terminals.2015
- Author(s)
  Liu L, Nishimura M
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26430070
[Presentation] Pre-synaptic localization of p24α2 in the mammalian brain.2015
- Author(s)
  Liu L, Nishimura M
- Organizer
  第56回日本神経科学会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26430070
[Presentation] ILEIはアルツハイマー病モデルマウスのアミロイド沈着と記憶障害を軽減させる2014
- Author(s)
  劉磊, 長谷川浩史, 遠山育夫, 村山繁雄, 西村正樹
- Organizer
  第33回日本認知症学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590359
[Presentation] ILEI はアルツハイマー病モデルマウスのアミロイド沈着と記憶障害を軽減させる2014
- Author(s)
  劉磊, 長谷川浩史, 遠山育夫, 村山繁雄, 西村正樹
- Organizer
  第33回日本認知症学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] p24α2 interacts with γ-secretase complex at presynaptic terminals.2014
- Author(s)
  Nishimura M, Liu L, Fujino K.
- Organizer
  Alzheimer’s Association International Conference 2014
- Place of Presentation
  Copenhagen、デンマーク王国
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] Expression of p24α2 in mammalian brain.2014
- Author(s)
  Nishimura M, Lei Liu.
- Organizer
  Experimental Biology 2014
- Place of Presentation
  San Diego、アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] ILEI はAPP-C99 を不安定化することによりアミロイドβ産生を減少させる2014
- Author(s)
  劉磊, 長谷川浩史, 遠山育夫, 村山繁雄, 西村正樹
- Organizer
  第37回日本神経科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] ILEIはAPP-C99を不安定化することによりアミロイドβ産生を減少させる2014
- Author(s)
  劉磊, 長谷川浩史, 遠山育夫, 村山繁雄, 西村正樹
- Organizer
  第37回日本神経科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590359
[Presentation] p24α2 interacts with γ-secretase complex at presynaptic terminals2014
- Author(s)
  Nishimura M, Liu L, Fujino K
- Organizer
  Alzheimer's Association International Conference 2014
- Place of Presentation
  Copenhagen
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] Expression of p24α2 in mammalian brain2014
- Author(s)
  Nishimura M, Liu L
- Organizer
  Experimental Biology 2014
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] Modulation of Aβ42 production2013
- Author(s)
  Nishimura M
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] Modulation of Aβ42 production.2013
- Author(s)
  Nishimura M.
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  Kyoto
- Invited
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] γセクレターゼ活性阻害タンパク質p24α2のシナプス局在2013
- Author(s)
  劉　磊、西村正樹
- Organizer
  日本認知症学会
- Place of Presentation
  長野県松本市
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] Age-related modulation of γ-secretase activity in monkey brains.2012
- Author(s)
  Nishimura M, Nakamura S, Kimura N, Liu L, Suzuki T, Tooyama I.
- Organizer
  Alzheimer’s Association International Conference 2012
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] Membrane microdomain localization of APP C-terminal fragments regulated by phosphorylation at cytoplasmic Thr668 residue2012
- Author(s)
  Matsushima T, Saito Y, Nishimura M, Kimura N, Hata S, Suzuki T
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancouver
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] Age-related modulation of γ-secretase activity in monkey brains2012
- Author(s)
  Nishimura M, Nakamura S, Kimura N, Liu L, Suzuki T, Tooyama I
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancouver
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] 加齢に伴うカニクイザル脳γセクレターゼ活性の修飾 : Aβ42 産生比の増加2012
- Author(s)
  西村正樹, 劉磊, 中村紳一朗, 木村展之, 鈴木利治, 遠山育夫
- Organizer
  第31回日本認知症学会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter2011
- Author(s)
  Matsuo A, Bellier JP, Nishimura M, Yasuhara O, Saito N, Kimura H
- Organizer
  The 8th IBRO World Congress of Neuroscience
- Place of Presentation
  Florence
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] Interaction of p24α2 with γ-secretase complex attenuates γ-cleavage of APP.2011
- Author(s)
  Nishimura M, et al.
- Organizer
  Alzheimer’s Association International Conference 2011
- Place of Presentation
  Paris
- Data Source
  KAKENHI-PROJECT-23590359
[Presentation] Interaction of p24α2 with γ-secretase complex attenuates γ-cleavage of APP.2011
- Author(s)
  Nishimura M, et al.
- Organizer
  Alzheimer’s Association International Conference 2011
- Place of Presentation
  Paris
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] Interaction of p24a2 with γ-secretase complex attenuates γ-cleavage of APP2011
- Author(s)
  Nishimura M, Liu L, Hasegawa H
- Organizer
  Alzheimer's Association International 2011 Conference on Alzheimer's Disease
- Place of Presentation
  フランス、パリ
- Year and Date
  2011-07-18
- Data Source
  KAKENHI-PROJECT-23300155
[Presentation] Interaction of p24α2 with γ-secretase complex attenuates γ-cleavage of APP2011
- Author(s)
  Nishimura M, Liu L, Hasegawa H
- Organizer
  Alzheimer's Association International Conference 2011
- Place of Presentation
  Paris
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] CRB2 binds to presenilin complexes resulting in inhibited secretion of Amyloid-β peptides2007
- Author(s)
  Nishimura, M., et. al.
- Organizer
  The 26th Meeting of Japanese Society for Dementia Research
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-18023019
[Presentation] ILEIはアルツハイマー病モデルマウスのアミロイド沈着と記憶障害を軽減させる
- Author(s)
  劉　磊、長谷川浩史、遠山育夫、村山繁雄、西村正樹
- Organizer
  第33回日本認知症学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26430070
[Presentation] ILEI reduces amyloid-β generation by destabilizing APP-C99
- Author(s)
  Liu L, Hiroshi Hasegawa H, Tooyama I, Murayama S, Nishimura M
- Organizer
  第37回日本神経科学会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26430070
[Presentation] p24α2 interacts with γ-secretase complex at presynaptic terminals
- Author(s)
  Nishimura M, Liu L, Fujino K
- Organizer
  Alzheimer’s Association International Conference 2014
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-07-12 – 2014-07-17
- Data Source
  KAKENHI-PROJECT-26430070
[Presentation] Neuronal ILEI reduces amyloid-β production by destabilizing amyloid precursor protein
- Author(s)
  Nishimura M, Liu L, Tooyama I
- Organizer
  The 12th International Conference on Alzheimer's & Parkison's Diseases
- Place of Presentation
  Nice, France
- Year and Date
  2015-03-18 – 2015-03-22
- Data Source
  KAKENHI-PROJECT-26430070
[Presentation] Expression of p24α2 in mammalian brain
- Author(s)
  Nishimura M, Liu L
- Organizer
  Experimental Biology 2014
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-04-26 – 2014-04-30
- Data Source
  KAKENHI-PROJECT-26430070

1. MATSUO Akinori (20324585)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 中野将希 (00823890)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. NAKAMURA Shinichiro (50307980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. OKADA Takashi (00326823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HASEGAWA Hiroshi (40432299)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 鈴木利治 (80179233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 森島真帆 (50204722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 駒野宏人 (40170378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 矢部大介 (60378643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 石浦章一 (10158743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 岡田尚巳 (00326828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. J・P Bellier (80346022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 渡邊直希 (60769339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
14. 三浦克之 (90257452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中野恭幸 (00362377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中川義久 (00378613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 原田亜紀子 (00451774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 長尾智晴 (10180457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 渡邉嘉之 (20362733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 近藤慶子 (20566567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 鳥居さゆ希 (30773973)

# of Collaborated Projects: 1 results

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22. 漆谷真 (60332326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 門田文 (60546068)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 尾關祐二 (90303768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 吉田和道 (90598921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 矢野裕一朗 (10586241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 椎野顯彦 (50215935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 岡見雪子 (60591401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 辻篤司 (70335173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 安藤朗 (90252395)

# of Collaborated Projects: 1 results

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31. HATA Saori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. TAKANO Jiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. TSUCHIYA Hideaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. OUCHI Yasuomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 長谷川寿一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 村山繁雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 長谷川成人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 森雅樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
39. 伊藤靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 依馬正次

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 小笠原一誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 佐々木えりか

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishimura Masaki 西村 正樹

NISHIMURA Masaki 西村 正樹

西村 正樹 ニシムラ マサキ

Research Projects

Research Products

Co-Researchers

老化関連因子が脳Aβ蓄積を促進する分子メカニズムの解析Principal Investigator

Principal Investigator

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認知症予測の網羅的モデル開発のための一般集団における脳画像長期追跡疫学研究

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Identification of circulating factors triggering molecular pathological processes of Alzheimer's diseasePrincipal Investigator

Principal Investigator

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Development of preventive therapy for Alzheimer's disease by modification in expressional levels of the risk genesPrincipal Investigator

Principal Investigator

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Review Section

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Neuron-specific mechanism for production and secretion of amyloid-beta and therapeutic regulation of its depositionPrincipal Investigator

Principal Investigator

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Model animals by nonhuman primate for Alzheimer disease, hyper expression of mutant amyloid precursor protein and formation of senile plaques in the brain

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Development of therapeutic strategy for Alzheimer's disease by targeting amyloid precursor protein C99Principal Investigator

Principal Investigator

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Functional analysis of the novel modulator of gamma secretase

Principal Investigator

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長鎖アミロイドβ生成の調節メカニズム解明とその抑制法開発Principal Investigator

Principal Investigator

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RIPによる細胞内情報伝達機構

Principal Investigator

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Clarification of the mechanism underlying y-secretase cleavage by presenilin complexesPrincipal Investigator

Principal Investigator

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Review Section

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Clarification of Molecular Mechanism For-AmyloidβGeneration in Alzheimer's DiseasePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

アルツハイマー病プレセニリン複合体の構成蛋白同定と機能解析に関する研究Principal Investigator

Principal Investigator

Nishimura Masaki 西村正樹

NISHIMURA Masaki 西村正樹

西村正樹ニシムラマサキ