MAEHAMA Tomohiko 前濱朝彦

… Alternative Names

Maehama Tomohiko 前濱朝彦

前濱朝彦マエハマトモヒコ

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Researcher Number	40322755
Other IDs	https://orcid.org/0000-0002-9685-2317
External Links
Affiliation (Current)	2025: 昭和大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2024: 昭和大学, 医学部, 教授 2016 – 2020: 神戸大学, 医学研究科, 准教授 2015: 国立感染症研究所, 細胞化学部, 室長 2006 – 2012: 国立感染症研究所, 細胞化学部, 室長 2005: (財)東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 … More 2005: 東京都臨床総合研究所, 薬理学部門, 研究員 2004 – 2005: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 2003: TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH, THE TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE, INVESTIGATOR, 研究員 2003: (財)東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 2001 – 2002: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / Biological Sciences / Basic Section 43030:Functional biochemistry-related Except Principal Investigator Cell biology / Functional biochemistry / Pathological medical chemistry
Keywords	Principal Investigator シグナル伝達 / 核小体ストレス / PICT1 / GTP結合タンパク質 / タンパク質合成 / イノシトールリン脂質 / 脂質 / リボソーム病 / ストレス応答 / リボソームストレス … More / ＰＩＣＴ１ / Gタンパク質 / G蛋白質 / 細胞情報伝達機構 / 発現制御 / 蛋白質 / mTOR / GTP結合蛋白質 / ランダム変異 / タンパク質分解 / 感染症 / ウイルス / 細胞内シグナル伝達 / 癌抑制遺伝子 / 酵素 / 癌 … More Except Principal Investigator PIP5Kγ661 / PIP5Kβ / Signal transduction / シグナル伝達 / NGF / ERK / ホスホリパーゼD / Endocytosis / Synaptic vesicle / AP-2 adaptor complex / Spine / Signaling lipid-producing enzyme / アナフィラキシー / 高次脳機能 / ノックアウトマウス / ヒスタミン放出反応 / 肥満細胞 / PIP5K / 脂質シグナル分子 / 脂質性シグナル分子産生酵素 / エンドサイトーシス / シナプス小胞 / AP-2複合体 / スパイン / 脂質性シグナル分子産生酵 / Neuronal adhesion molecule / Cerebellar granule cells / PC 12 cells / Neurite / Phospholipase D / 一級アルコール / 神経細胞接着分子 / 軸索伸長 / 小脳顆粒細胞 / 神経接着分子 / 小脳果顆粒細胞 / PC12細胞 / 神経軸策 / PTEN / PICT1 / 癌抑制遺伝子 Less

Study on the molecular mechanism of nucleolar stress responsePrincipal Investigator
- Principal Investigator
  
  前濱朝彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Showa University
Study of PICT1-mediated nucleolar stress response and tumorigenesisPrincipal Investigator
- Principal Investigator
  
  Maehama Tomohiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Kobe University
Nucleolar stress sensing in the nucleolusPrincipal Investigator
- Principal Investigator
  
  Maehama Tomohiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
  National Institute of Infectious Diseases
Analyses of intracellular signals using a novel activation method for small GTPasesPrincipal Investigator
- Principal Investigator
  
  MAEHAMA Tomohiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  National Institute of Infectious Diseases
G蛋白質の迅速な活性化手法の開発Principal Investigator
- Principal Investigator
  
  前濱朝彦
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  National Institute of Infectious Diseases
栄養素感知システムを構成するGサイクル制御の解明Principal Investigator
- Principal Investigator
  
  前濱朝彦
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
A study on lipid dynamics during pathogen infectionPrincipal Investigator
- Principal Investigator
  
  MAEHAMA Tomohiko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Institute of Infectious Diseases
FACSを利用した新規なタンパク質機能モチーフ探索法の開発Principal Investigator
- Principal Investigator
  
  前濱朝彦
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  National Institute of Infectious Diseases
Rheb GEFの同定とその活性化機構の解析Principal Investigator
- Principal Investigator
  
  前濱朝彦
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
新規癌抑制候補遺伝子による発癌制御の検討
- Principal Investigator
  
  鈴木聡
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Akita University
PICT-1による癌抑制遺伝子産物PTENの活性制御機構の解析Principal Investigator
- Principal Investigator
  
  前濱朝彦
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
STUDIES ON FUNCTION AND SHIGNALING MECHANISM OF LIPID SIGNALING MOLECULE-PRODUCING ENZYME FOR ESTABLISHMENT OF HIGHLY ORGANIZED BRAIN FUNCTION
- Principal Investigator
  
  KANAHO Yasunori
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  UNIVERSITY OF TSUKUBA
  Tokyo Metropolitan Organization for Medical Research
STUDY ON FUNCTION OF PHOSPHOLIPASE D2 IN NEURITE REMODELING
- Principal Investigator
  
  KANAHO Yasunori
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH
癌抑制遺伝子PTENの変異による細胞癌化メカニズムの解明Principal Investigator
- Principal Investigator
  
  前濱朝彦
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research

[Journal Article] YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma2020
- Author(s)
  Omori Hirofumi、Nishio Miki、Masuda Muneyuki、Miyachi Yosuke、Ueda Fumihito、Nakano Takafumi、Sato Kuniaki、Mimori Koshi、Taguchi Kenichi、Hikasa Hiroki、Nishina Hiroshi、Tashiro Hironori、Kiyono Tohru、Mak Tak Wah、Nakao Kazuwa、Nakagawa Takashi、Maehama Tomohiko、Suzuki Akira
- Journal Title
  
  Science Advances
  
  Volume: 6 Issue: 12 Pages: 3324-3324
- DOI
  10.1126/sciadv.aay3324
- NAID
  120006818745
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06132, KAKENHI-PROJECT-18K06232, KAKENHI-PROJECT-18K08638, KAKENHI-PROJECT-17H01566, KAKENHI-PROJECT-18K15240, KAKENHI-PROJECT-20K09621, KAKENHI-PROJECT-20K20661, KAKENHI-PUBLICLY-20H05039, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-19H03715, KAKENHI-PROJECT-20H03381
[Journal Article] Dynamism of PI4-Phosphate during Interactions with Human Erythrocytes in Entamoeba histolytica2020
- Author(s)
  Watanabe Natsuki、Nakada-Tsukui Kumiko、Maehama Tomohiko、Nozaki Tomoyoshi
- Journal Title
  
  Microorganisms
  
  Volume: 8 Issue: 7 Pages: 1050-1050
- DOI
  10.3390/microorganisms8071050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05353, KAKENHI-PROJECT-18H02650, KAKENHI-PROJECT-19H03463, KAKENHI-PROJECT-18K06132
[Journal Article] 哺乳類Hippo経路による細胞接着の制御と細胞競合2020
- Author(s)
  前濱朝彦、西尾美希、鈴木聡
- Journal Title
  
  医学のあゆみ
  
  Volume: 274 Pages: 457-462
- Data Source
  KAKENHI-PROJECT-18K06132
[Journal Article] The role of Hippo-YAP signaling in squamous cell carcinomas.2020
- Author(s)
  Tomohiko Maehama , Miki Nishio , Junji Otani , Tak Wah Mak , Akira Suzuki
- Journal Title
  
  Cancer science
  
  Volume: 112 Issue: 1 Pages: 51-60
- DOI
  10.1111/cas.14725
- NAID
  120006950333
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07572, KAKENHI-PROJECT-20K07590, KAKENHI-PROJECT-20K20661, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-18K06132
[Journal Article] Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.2020
- Author(s)
  Miki Nishio , Yoko To , Tomohiko Maehama , Yukari Aono , Junji Otani , Hiroki Hikasa , Akihiro Kitagawa , Koshi Mimori , Takehiko Sasaki , Hiroshi Nishina , Shinya Toyokuni , John P Lydon , Kazuwa Nakao , Tak Wah Mak , Tohru Kiyono , Hidetaka Katabuchi , Hironori Tashiro , Akira Suzuki
- Journal Title
  
  Cancer science
  
  Volume: 111 Issue: 10 Pages: 3576-3578
- DOI
  10.1111/cas.14581
- NAID
  120006892076
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07572, KAKENHI-PROJECT-20K07590, KAKENHI-PROJECT-20K09621, KAKENHI-PROJECT-20K20661, KAKENHI-PUBLICLY-20H05039, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-19H03715, KAKENHI-PROJECT-20H03381, KAKENHI-PROJECT-18K06132, KAKENHI-PROJECT-18K06232, KAKENHI-PROJECT-16H06276
[Journal Article] Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency2019
- Author(s)
  Nishio Miki、Miyachi Yousuke、Otani Junji、Tane Shoji、Omori Hirofumi、Ueda Fumihito、Togashi Hideru、Sasaki Takehiko、Mak Tak Wah、Nakao Kazuwa、Fujita Yasuyuki、Nishina Hiroshi、Maehama Tomohiko、Suzuki Akira
- Journal Title
  
  The FASEB Journal
  
  Volume: 33 Issue: 4 Pages: 5548-5560
- DOI
  10.1096/fj.201802005r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15211, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-16K08626, KAKENHI-PROJECT-18K06132, KAKENHI-PROJECT-18K06219, KAKENHI-ORGANIZER-15H05897, KAKENHI-PUBLICLY-18H04764, KAKENHI-PUBLICLY-19H04965, KAKENHI-PROJECT-17H01566, KAKENHI-PROJECT-18H03994, KAKENHI-PROJECT-17H03980, KAKENHI-PROJECT-19K22508, KAKENHI-PLANNED-15H05899
[Journal Article] MOB1 regulates thymocyte egress and T‐cell survival in mice in a YAP1‐independent manner2019
- Author(s)
  Kato Wakako、Nishio Miki、To Yoko、Togashi Hideru、Mak Tak Wah、Takada Hidetoshi、Ohga Shouichi、Maehama Tomohiko、Suzuki Akira
- Journal Title
  
  Genes to Cells
  
  Volume: 24 Issue: 7 Pages: 485-495
- DOI
  10.1111/gtc.12704
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06132, KAKENHI-PROJECT-18K06219, KAKENHI-PUBLICLY-18H04764, KAKENHI-PUBLICLY-19H04965, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-19H03613
[Journal Article] Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica2019
- Author(s)
  Nakada-Tsukui Kumiko、Watanabe Natsuki、Maehama Tomohiko、Nozaki Tomoyoshi
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 9 Pages: 150-150
- DOI
  10.3389/fcimb.2019.00150
- NAID
  120006649617
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06132, KAKENHI-PROJECT-19H03463, KAKENHI-PROJECT-18H02650
[Journal Article] Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9.2018
- Author(s)
  Goto H, Nishio M, To Y, Oishi T, Miyachi Y, Maehama T, Nishina H, Akiyama H, Mak TW, Makii Y, Saito T, Yasoda A, Tsumaki N, Suzuki A.
- Journal Title
  
  Development
  
  Volume: 145 Issue: 6 Pages: 159244-159244
- DOI
  10.1242/dev.159244
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08626, KAKENHI-PROJECT-17K16188, KAKENHI-PROJECT-15K07020, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-17H01400
[Journal Article] MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene2017
- Author(s)
  Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, Nishie W, Sasaki T, Maehama T, Nishina H, Mimori K, Nakano T, Shimizu H, Mak TW, Nakao K, Nakanishi Y, Suzuki A
- Journal Title
  
  Oncogene
  
  Volume: 印刷中 Issue: 29 Pages: 4201-4211
- DOI
  10.1038/onc.2017.58
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15495, KAKENHI-PROJECT-15K19026, KAKENHI-PROJECT-15K07020, KAKENHI-PROJECT-16K08626, KAKENHI-PROJECT-17K19608, KAKENHI-PUBLICLY-16H01576, KAKENHI-PUBLICLY-17H05996, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-17H01566, KAKENHI-PROJECT-15H04921, KAKENHI-PROJECT-17H03982, KAKENHI-PROJECT-26640081
[Journal Article] Hippo vs. Crab: tissue-specific functions of the mammalian Hippo pathway2017
- Author(s)
  M. Nishio, T. Maehama, H. Goto, K. Nakatani, W. Kato, H. Omori, Y. Miyachi, H. Togashi, Y. Shimono and A. Suzuki
- Journal Title
  
  Genes to Cells
  
  Volume: 22 Issue: 1 Pages: 6-31
- DOI
  10.1111/gtc.12461
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26400205, KAKENHI-PROJECT-15K14381, KAKENHI-PROJECT-15K19026, KAKENHI-PROJECT-15K07020, KAKENHI-PROJECT-16K08626, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-17H01400
[Journal Article] Targeting the Hippo signalling pathway for cancer treatment2016
- Author(s)
  K. Nakatani, T. Maehama, M. Nishio, H. Goto, W. Kato, H. Omori, Y. Miyachi, H. Togashi, Y. Shimono and A. Suzuki
- Journal Title
  
  J. Biochem.
  
  Volume: 161 Pages: 237-244
- DOI
  10.1093/jb/mvw074
- NAID
  40021162008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26400205, KAKENHI-PROJECT-15K14381, KAKENHI-PROJECT-15K19026, KAKENHI-PROJECT-15K07020
[Journal Article] PTEN2015
- Author(s)
  前濱朝彦、鈴木聡
- Journal Title
  
  日本臨牀増刊号
  
  Volume: 73 Pages: 285-290
- Data Source
  KAKENHI-PROJECT-15K07020
[Journal Article] PTEN：脂質ホスファターゼとしての機能と発がんへの関与2015
- Author(s)
  前濱朝彦、鈴木聡
- Journal Title
  
  実験医学増刊
  
  Volume: 15 Pages: 157-163
- Data Source
  KAKENHI-PROJECT-15K07020
[Journal Article] 核小体を起点としp53を制御する新規分子PICT1による細胞増殖制御機構2013
- Author(s)
  西尾美希、河原康一、佐々木雅人、前濱朝彦、佐々木雄彦、三森功士、森正樹、鈴木聡
- Journal Title
  
  実験医学増刊
  
  Volume: 31 Pages: 127-134
- Data Source
  KAKENHI-PROJECT-23657095
[Journal Article] A new PICTure of nucleolar stress2012
- Author(s)
  Suzuki A, Kogo R, Kawahara K, Sasaki M, Nishio M, Maehama T, Sasaki T, Mimori K, Mori M.
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Issue: 4 Pages: 632-7
- DOI
  10.1111/j.1349-7006.2012.02219.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592132, KAKENHI-PROJECT-23657095, KAKENHI-PROJECT-24240120, KAKENHI-PUBLICLY-24112515
[Journal Article] Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL112011
- Author(s)
  Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wang J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Zhu Y, Prives C, Nakano T, Mak TW, Sasaki T, Maehama T, Mori M, Suzuki A
- Journal Title
  
  Nat Med
  
  Volume: 17 Issue: 8 Pages: 944-951
- DOI
  10.1038/nm.2392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501257, KAKENHI-PROJECT-23592132, KAKENHI-PROJECT-23657095
[Journal Article] An improved method for cell-to-cell transmission of infectious prion.2010
- Author(s)
  Tanaka, M., Hara, H., Nishina, H., Hanada, K., Hagiwara, K., Maehama, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370058
[Journal Article] アミノ酸感知シグナル -mTOR活性化の分子機構-2009
- Author(s)
  前濱朝彦
- Journal Title
  
  アミノ酸研究 3
  
  Pages: 5-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21657035
[Journal Article] アミノ酸感知シグナル2009
- Author(s)
  前濱朝彦
- Journal Title
  
  細胞工学 28
  
  Pages: 760-764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20054024
[Journal Article] アミノ酸感知シグナル-mTOR活性化の分子機構-2009
- Author(s)
  前濱朝彦
- Journal Title
  
  アミノ酸研究 3
  
  Pages: 5-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20054024
[Journal Article] アミノ酸感知シグナル2009
- Author(s)
  前濱朝彦
- Journal Title
  
  細胞工学 28
  
  Pages: 760-764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370058
[Journal Article] アミノ酸感知シグナル -mTOR活性化の分子機構-2009
- Author(s)
  前濱朝彦
- Journal Title
  
  アミノ酸研究 3
  
  Pages: 5-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370058
[Journal Article] アミノ酸感知シグナル2009
- Author(s)
  前濱朝彦
- Journal Title
  
  細胞工学 28
  
  Pages: 760-764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21657035
[Journal Article] Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid-induced migration by isoproterenol in glioma cells.2009
- Author(s)
  Malchinkhuu, E., Sato, K., Maehama, T., Ishiuchi, S., Yoshimoto, Y., Mogi, C., Kimura, T., Kurose, H., Tomura, H., Okajima, F.
- Journal Title
  
  Mol. Biol. Cell 20
  
  Pages: 5156-5165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370058
[Journal Article] アミノ酸感知シグナル-mTOR活性化の分子機構-2009
- Author(s)
  前濱朝彦
- Journal Title
  
  アミノ酸研究 3
  
  Pages: 5-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370058
[Journal Article] あらたな癌抑制遺伝子PICT-1/GLTSCR22008
- Author(s)
  前濱朝彦
- Journal Title
  
  医学のあゆみ 224
  
  Pages: 172-173
- Data Source
  KAKENHI-PROJECT-18057028
[Journal Article] RalA functions as an indispensable signal mediator for the nutrient-sensing system2008
- Author(s)
  Maehama, T.
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 35053-35059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370058
[Journal Article] RalA functions as an indispensable signal mediator for the nutrient-sensing system.2008
- Author(s)
  Maehama, T., Tanaka, M., Nishina, H., Murakami, M., Kanaho, Y., Hanada, K.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 35053-35059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370058
[Journal Article] あらたな癌抑制遺伝子PICT-1/GLTSCR22008
- Author(s)
  前濱朝彦
- Journal Title
  
  医学のあゆみ 224
  
  Pages: 172-173
- Data Source
  KAKENHI-PROJECT-19370058
[Journal Article] RalA functions as an indispensable singnal mediator for the untrient-sensing system2008
- Author(s)
  Maehama, T.
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 35053-35059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19657044
[Journal Article] あらたな癌抑制遺伝子PICT-1/GLTSCR22008
- Author(s)
  前浜朝彦
- Journal Title
  
  医学のあゆみ 224
  
  Pages: 172-173
- Data Source
  KAKENHI-PROJECT-19657044
[Journal Article] S1P2 receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.2008
- Author(s)
  Malchinkhuu, E., Sato, K., Maehama, T., Mogi, C., Tomura, H., Ishiuchi, S., Yoshimoto, Y., Kurose, H., Okajima, F.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 366
  
  Pages: 963-968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370058
[Journal Article] あらたな癌抑制遺伝子PICT-1/GLTSCR22008
- Author(s)
  前濱朝彦、岡原史明、金保安則
- Journal Title
  
  医学のあゆみ 224
  
  Pages: 172-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370058
[Journal Article] RalA functions as an indispensable signal mediator for the nutrient-sensing system2008
- Author(s)
  Maehama, T.
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 35053-35059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20054024
[Journal Article] PTEN:its deregulation and tumorigenesis2007
- Author(s)
  Maehama, T.
- Journal Title
  
  Biol.Pharm.Bull. 30
  
  Pages: 1624-1627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19657044
[Journal Article] PTEN:its deregulation and tumorigenesis2007
- Author(s)
  Maehama, T
- Journal Title
  
  Biol.Pharm.Bull 30
  
  Pages: 1624-1627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18057028
[Journal Article] PTEN: its deregulation and tumorigenesis.2007
- Author(s)
  Maehama, T.
- Journal Title
  
  Biol. Pharm. Bull. 30
  
  Pages: 1624-1627
- NAID
  110006380239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370058
[Journal Article] PTEN:its deregulation and tumorigenesis2007
- Author(s)
  Maehama, T.
- Journal Title
  
  Biol.Pharm.Bull. 30
  
  Pages: 1624-1627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370058
[Journal Article] リン脂質ボスファターゼPTENの新しい活性調節機構2006
- Author(s)
  前濱朝彦
- Journal Title
  
  生化学 78
  
  Pages: 133-137
- Data Source
  KAKENHI-PROJECT-16770107
[Journal Article] Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I α.2005
- Author(s)
  J.Sasaki, T.Sasaki, M.Yamazaki, K.Matsuoka, C.Taya, H.Shitara, S.Takasuga, M.Nishio, K.Mizuno, T.Wada, H.Miyazaki, H.Watanabe, R.Iizuka, S.Kubo, S.Murata, T.Chiba, T.Maehama, MA.Frohman, K.Tanaka, JM.Penninger, H.Yonekawa, A.Suzuki, Y.Kanaho
- Journal Title
  
  J.Exp.Med. 201
  
  Pages: 859-870
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370091
[Journal Article] The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation2005
- Author(s)
  H.Miyazaki, M.Yamazaki, H.Watanabe, T.Maehama, T.Yokozeki, Y.Kanaho
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 6834-6837
- Data Source
  KAKENHI-PROJECT-16370091
[Journal Article] Production of research-grade antibody by in vivo electroporation of DNA encoding target protein2005
- Author(s)
  F.Okahara, K.Itoh, M.Ebihara, M.Kobayashi, H.Maruyama, Y.Kanaho, T.Maehama
- Journal Title
  
  Anal. Biochem. 336
  
  Pages: 138-140
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370091
[Journal Article] The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation2005
- Author(s)
  H.Miyazaki, M.Yamazaki, H.Watanabe, T.Maehama, T.Yokozaki, Y.Kanaho
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 6834-6837
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370091
[Journal Article] Production of research-grade antibody by in vivo electroporation of DNA encoding target protein.2005
- Author(s)
  F.Okahara, K.Itoh, M.Ebihara, M.Kobayashi, H.Maruyama, Y.Kanaho, T.Maehama
- Journal Title
  
  Anal.Biochem. 336
  
  Pages: 138-140
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370091
[Journal Article] The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation.2005
- Author(s)
  H.Miyazaki, M.Yamazaki, H.Watanabe, T.Maehama, T.Yokozeki, Y.Kanaho
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 6834-6837
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370091
[Journal Article] Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN2004
- Author(s)
  Maehama, T.他
- Journal Title
  
  FEBS Lett. 565
  
  Pages: 43-47
- Data Source
  KAKENHI-PROJECT-16770107
[Presentation] Squamous cell carcinoma onset and progression driven by multistep YAP activation2020
- Author(s)
  Tomohiko Maehama, Miki Nishio, Hirofumi Omori, Akira Suzuki
- Organizer
  The 14th International Conference on Protein Phosphatase
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] YAPの多段階活性化による扁平上皮癌の発症・進展の制御2020
- Author(s)
  前濱朝彦、西尾美希、大森裕文、鈴木聡
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] YAP1/TAZ阻害による抗腫瘍作用を示す天然物の同定2020
- Author(s)
  西尾美希、中谷圭祐、大谷淳二、日笠弘基、前濱朝彦、鈴木聡
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] YAPの多段階活性化による扁平上皮癌の発症・進展の制御2020
- Author(s)
  前濱朝彦、西尾美希、大森裕文、鈴木聡
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] Hippo経路による扁平上皮癌の制御2020
- Author(s)
  前濱朝彦、西尾美希、大森裕文、田代浩徳、中尾一和、鈴木聡
- Organizer
  第57回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] A natural product Alantolactone is a potent YAP1/TAZ inhibitor via ROS production2020
- Author(s)
  Junji Otani, Keisuke Nakatani, Tomohiko Maehama, Miki Nishio, Akira Suzuki
- Organizer
  The 14th International Conference on Protein Phosphatase
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] Regulation of nucleolar stress response and tumorigenesis by PICT12019
- Author(s)
  Maehama Tomohiko、Nishio Miki、Miyachi Yosuke、Suzuki Akira
- Organizer
  Frontiers of Cell Signaling in 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] Hippoシグナル経路による細胞競合機構2019
- Author(s)
  前濱朝彦、西尾美希、宮地洋佑、大谷淳二、上田史仁、富樫英、鈴木聡
- Organizer
  第9回日本プロテインホスファターゼ研究会学術集会
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] The tumor suppressor PTEN: its function and regulation2019
- Author(s)
  Maehama Tomohiko、Nishio Miki、Suzuki Akira
- Organizer
  Tohoku Forum for Creativity "Cancer - from Biology to Acceptance"
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] 核小体ストレスーRNAを介した応答機構2019
- Author(s)
  前濱朝彦、宮地洋佑、西尾美希、大谷淳二、上田史人、鈴木聡
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] 子宮頸がん発症におけるHippo経路の役割2019
- Author(s)
  前濱朝彦、西尾美希、藤庸子、清野透、田代浩徳、鈴木聡
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] Hippoキナーゼ経路による生体制御2018
- Author(s)
  西尾美希、大森裕文、藤庸子、前濱朝彦、田代浩徳、鈴木聡
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] 赤痢アメーバ原虫のホスファチジルイノシトールシグナルと貪食胞成熟の分子機構2018
- Author(s)
  津久井久美子、渡辺菜月、前濱朝彦、野崎智義
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] 子宮におけるがん抑制遺伝子MOB1の機能解析2018
- Author(s)
  青野ゆかり、西尾美希、藤庸子、前濱朝彦、清野透、片渕秀隆、田代浩徳、鈴木聡
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] Hippo経路分子Mob1変異による肝がん発症機構2018
- Author(s)
  西尾美希、大森裕文、藤庸子、中谷圭祐、青野ゆかり、清野透、益田宗幸、中川尚志、片渕秀隆、田代浩徳、前濱朝彦、鈴木聡
- Organizer
  第41回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] がん制御因子PICT1の安定化機構2018
- Author(s)
  宮地洋佑、前濱朝彦、西尾美希、鈴木聡
- Organizer
  第65回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] HECT型E3リガーゼWWP2によるPTEN制御の分子機構解析2018
- Author(s)
  福本未記、前濱朝彦、北山翔太、西尾美希、鈴木聡
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06132
[Presentation] がん制御因子PICT1の安定化機構2017
- Author(s)
  前濱朝彦、宮地洋佑、西尾美希、鈴木聡
- Organizer
  2017年度生命科学系学会合同年次大会ConBio
- Data Source
  KAKENHI-PROJECT-15K07020
[Presentation] Role of Hippo pathway in vivo2017
- Author(s)
  Nishio M, Maehama T, Togashi H, et al.
- Organizer
  神戸大学・ワシントン大学・オスロ大学国際合同シンポジウム
- Place of Presentation
  神戸大学（兵庫県神戸市）
- Year and Date
  2017-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07020
[Presentation] Regulation of nucleolar stress response and tumorigenesis by PICT12017
- Author(s)
  Tomohiko Maehama, Miki Nishio, Yosuke Miyachi, Akira Suzuki
- Organizer
  第２回神大・ワシントン大・オスロ大国際合同シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07020
[Presentation] Role of MOB1A/1B in salivary gland2017
- Author(s)
  Yosuke Miyachi, Miki Nishio, Hiroki Goto, Tomohiko Maehama, Akira Suzuki
- Organizer
  EMBO workshop ‘The Hippo pathway across species and disciplines’
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07020
[Presentation] Hippo signaling pathway affects cell competion in mammalian cells via cell-ECM binding and anchorage-dependent cell proliferation2017
- Author(s)
  Miki Nishio, Tomohiko Maehama, Akira Suzuki
- Organizer
  3rd International Symposium on Cell Competition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07020
[Presentation] 遺伝子改変動物を利用した、形態形成におけるHippo経路の機能解析2016
- Author(s)
  田中雅人、後藤裕樹、前濱朝彦、他
- Organizer
  第48回日本臨床分子形態学会ワークショップⅢ
- Place of Presentation
  くまもと県民交流館パレア（熊本県熊本市）
- Year and Date
  2016-09-23
- Data Source
  KAKENHI-PROJECT-15K07020
[Presentation] Nucleolar stress induces ubiquitin-independent proteasomal degradation of PICT12013
- Author(s)
  Tomohiko Maehama, et al
- Organizer
  10th International Conference on Protein Phosphatase
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23657095
[Presentation] Nucleolar stress induces ubiquitin-independent proteasomal degradation of PICT12013
- Author(s)
  Maehama, T., Kawahara, K., Nishio, M., Suzuki, A
- Organizer
  10th International Conference on Protein Phosphatase
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-23657095
[Presentation] mTORC1制御に関与するGタンパク質群の解析2012
- Author(s)
  前濱朝彦
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23657095
[Presentation] mTORC1制御に関与するGタンパク質群の解析2012
- Author(s)
  前濱朝彦
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23657095
[Presentation] mTORC1制御に関与するGタンパク質群の解析2010
- Author(s)
  前濱朝彦
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21657035
[Presentation] 共培養系を用いた高効率なPrPSc伝播実験系の確立2009
- Author(s)
  田中正彦、原英之、萩原健一、花田賢太郎、仁科博史、前濱朝彦
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-19370058
[Presentation] mTORC1活性化の分子機構-アミノ酸感知シグナル-2009
- Author(s)
  前濱朝彦
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフイコ横浜(横浜市)
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-20054024
[Presentation] Identification of a Ras-family GTPase as an indispensable signal mediator for nutrient sensing and mTORC1 activation2008
- Author(s)
  Maehama, T.
- Organizer
  8th International Conference on Protein Phosphatases
- Place of Presentation
  群馬県前橋市
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-19370058
[Presentation] Identification of a Ras-family GTPase as an indispensable signal mediator for nutrient sensing and mTORC1 activation2008
- Author(s)
  Maehama, T.
- Organizer
  8th International Conference on Protein Phosphatases
- Place of Presentation
  群馬県前橋市
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-20054024
[Presentation] Identification of a Ras-family GTPase as an indispensable signal mediator for nutrient sensing and mTORC1 activation2008
- Author(s)
  Maehama, T.
- Organizer
  8th International Conference on Protein Phosphatases
- Place of Presentation
  Maebashi, Japan
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-19657044
[Presentation] アミノ酸応答の分子機構解析2007
- Author(s)
  前濱朝彦
- Organizer
  第6回生命科学研究会
- Place of Presentation
  千葉県千葉市
- Year and Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-18057028

1. SASAKI Takehiko (50333365)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KANAHO Yasunori (00214437)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. ITOH Kouichi (30291149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. WATANABE Hiroshi (80356261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YOKOZEKI Takeaki (80373405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 鈴木聡 (10311565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. MIYACHI Yosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. TOGASHI Hideru

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. KAWAHARA Kohichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 大谷淳二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 中尾一和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 津久井久美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山下孝之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 西尾美希

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

MAEHAMA Tomohiko 前濱 朝彦

Maehama Tomohiko 前濱 朝彦

前濱 朝彦 マエハマ トモヒコ

Research Projects

Research Products

Co-Researchers

Study on the molecular mechanism of nucleolar stress responsePrincipal Investigator

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Study of PICT1-mediated nucleolar stress response and tumorigenesisPrincipal Investigator

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Nucleolar stress sensing in the nucleolusPrincipal Investigator

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Analyses of intracellular signals using a novel activation method for small GTPasesPrincipal Investigator

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G蛋白質の迅速な活性化手法の開発Principal Investigator

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栄養素感知システムを構成するGサイクル制御の解明Principal Investigator

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A study on lipid dynamics during pathogen infectionPrincipal Investigator

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FACSを利用した新規なタンパク質機能モチーフ探索法の開発Principal Investigator

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Rheb GEFの同定とその活性化機構の解析Principal Investigator

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新規癌抑制候補遺伝子による発癌制御の検討

Principal Investigator

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PICT-1による癌抑制遺伝子産物PTENの活性制御機構の解析Principal Investigator

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STUDIES ON FUNCTION AND SHIGNALING MECHANISM OF LIPID SIGNALING MOLECULE-PRODUCING ENZYME FOR ESTABLISHMENT OF HIGHLY ORGANIZED BRAIN FUNCTION

Principal Investigator

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STUDY ON FUNCTION OF PHOSPHOLIPASE D2 IN NEURITE REMODELING

Principal Investigator

MAEHAMA Tomohiko 前濱朝彦

Maehama Tomohiko 前濱朝彦

前濱朝彦マエハマトモヒコ