Nagashima Kazuaki 長嶋一昭

… Alternative Names

NAGASHIMA Kazuaki 長嶋一昭

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Researcher Number	40324628
Other IDs
External Links
Affiliation (Current)	2025: 京都大学, 医学研究科, 客員研究員
Affiliation (based on the past Project Information) *help	2017 – 2020: 京都大学, 医学研究科, 客員研究員 2018: 京都大学, 医学研究科, 講師 2016: 京都大学, 医学研究科, 講師 2012 – 2015: 京都大学, 医学(系)研究科(研究院), 講師 2012: 京都大学, 大学院・医学研究科, 講師 … More 2010 – 2011: 京都大学, 医学研究科, 講師 2009: Kyoto University, 大学院・医学研究科, 助教 2007 – 2009: Kyoto University, Graduate School of Medicine, Assistant Professor 2004 – 2006: 京都大学, 医学研究科, 助手 2001 – 2002: 京都大学, 医学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Metabolomics / Metabolomics Except Principal Investigator Metabolomics / Biological Sciences
Keywords	Principal Investigator ATP / 糖代謝異常 / KATPチャネル / 糖尿病 / 膵島細胞 / K_<ATP>チャネル / 膵β細胞 / イオンチャネル / エネルギー・糖代謝異常 / 不均一性 … More / 糖代謝 / K_ATP チャネル / 糖質代謝異常 / エネルギー / 薬剤反応性 / 遺伝子 / 糖尿病学 / モデル化 / in silico / インスリン分泌促進薬 … More Except Principal Investigator イオンチャネル / 膵β細胞 / ion channel / membrane transport / ABC protein / lipid / protein / gene / 膜輸送 / ABC蛋白質 / 脂質 / 蛋白質 / 遺伝子 / intracelluar ATP concentration / intracellular Ca^<2+> concentration / exocytotic system / priming effect / glucose / insulin secretion / pancreatic β cell / pancreatic islet / ブドウ島 / 細胞内ATP濃度 / 細胞内Ca^<2+>濃度 / 開口放出機構 / プライミング効果 / ブドウ糖 / インスリン分泌 / 膵ランゲルハンス氏島 / 活性酸素 / 生理学 / 一酸化窒素 / カルシウム / TRPチャネル / 酸素受容器 / チャネル / ハイポキシア / 神経系 / アストロサイト / 酸素受容 / 低酸素 / イメージング / 細胞シグナル / 活性酸素種 / 酸素 / TGF-β / 遺伝子変異 / 転写因子 / アポトーシス / clusterin / TSC-22 / インスリン / 酸化ストレス / 2型糖尿病 Less

Metabolic and functional analysis of pancreatic islet cells using the fluorescent ATP probe gene knock-in mousePrincipal Investigator
- Principal Investigator
  
  NAGASHIMA KAZUAKI
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Molecular physiological studies of in vivo hypoxia niche: formation, sensing and adaptation
- Principal Investigator
  
  Mori Yasuo
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Functional analysis of pancreatic beta-cells in metabolic disorders using the fluorescent ATP probe gene transgenic mousePrincipal Investigator
- Principal Investigator
  
  NAGASHIMA KAZUAKI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Real-time measurement of intracellular ATP concentration using novel fluorescent ATP probe.Principal Investigator
- Principal Investigator
  
  NAGASHIMA Kazuaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Mutations in genes encoding the K_<ATP> channel and their influence on efficacy of insulinotropic agents.Principal Investigator
- Principal Investigator
  
  NAGASHIMA Kazuaki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
in silico 膵β細胞およびα細胞の機能的統合モデルの構築Principal Investigator
- Principal Investigator
  
  長嶋一昭
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Molecular Basis of Novel Membrane Transport Mechanism
- Principal Investigator
  
  INAGAKI Nobuya
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Kyoto University
  Akita University
酸化ストレスに基づく膵β細胞障害のシグナル伝達経路の解明
- Principal Investigator
  
  井原裕
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Okayama Prefectural University
インスリン分泌促進薬の薬理特性、および結合部位に基づくクラス分類の試みPrincipal Investigator
- Principal Investigator
  
  長嶋一昭
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
The mechanism of glucose-induced time-dependent potentiation of insulin secretion from pancreatic β cells and its alteration in diabetic state
- Principal Investigator
  
  FUJIMOTO Shimpei
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KYOTO UNIVERSITY

[Book] 食後高血糖の病態から各経口薬の特徴と併用療法の実際をみる2013
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  Life Style Medicine(in press)
- Data Source
  KAKENHI-PROJECT-22590977
[Book] スルホニル尿素薬. 糖尿病の分子標的と治療薬辞典2013
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22590977
[Book] 新生児糖尿病. International Review of Diabetes2012
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-22590977
[Book] SU 薬と速効型インスリン分泌促進薬. 糖尿病学イラストレイテッド2012
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22590977
[Book] 新生児糖尿病の病態・診断・治療. 最新臨床糖尿病学(下)2012
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-22590977
[Book] 最新臨床糖尿病学(上)2012
- Author(s)
  長嶋一昭, 他
- Publisher
  日本臨床社(印刷中)
- Data Source
  KAKENHI-PROJECT-22590977
[Book] 経口糖尿病治療薬の新展開-病態プロファイルと最適薬剤選択の決め手2012
- Author(s)
  長嶋一昭, 他
- Publisher
  フジメディカル出版(印刷中)
- Data Source
  KAKENHI-PROJECT-22590977
[Book] 最新臨床糖尿病学(下)2012
- Author(s)
  長嶋一昭, 他
- Publisher
  日本臨床社(印刷中)
- Data Source
  KAKENHI-PROJECT-22590977
[Book] SU 薬と速効型インスリン分泌促進薬(グリニド)-薬剤構造から薬理特性および薬効を考える-.糖尿病治療薬のサイエンス2012
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-22590977
[Book] 糖尿病学イラストレイテッド2012
- Author(s)
  長嶋一昭, 他
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22590977
[Book] 糖尿病治療薬のサイエンス2012
- Author(s)
  長嶋一昭, 他
- Publisher
  南山堂(印刷中)
- Data Source
  KAKENHI-PROJECT-22590977
[Book] 長嶋一昭、稲垣暢也2011
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  医学出版
- Data Source
  KAKENHI-PROJECT-22590977
[Book] ガイドライン外来診療20112011
- Author(s)
  長嶋一昭
- Total Pages
  16
- Publisher
  日経メディカル開発
- Data Source
  KAKENHI-PROJECT-22590977
[Book] 糖尿病とイオンチャネル. 細胞2011
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-22590977
[Book] 糖尿病レクチャー2010
- Author(s)
  長嶋一昭, 他
- Total Pages
  6
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-22590977
[Book] 糖尿病ナビゲーター(第2版)2010
- Author(s)
  長嶋一昭, 他
- Total Pages
  2
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-22590977
[Book] 糖尿病診療のABC2010
- Author(s)
  長嶋一昭, 他
- Total Pages
  5
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-22590977
[Book] 経口糖尿病薬-作用機序とエビデンス1.-;スルホニル尿素薬. 治療学2010
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  ライフサイエンス出版
- Data Source
  KAKENHI-PROJECT-19591047
[Book] 治療学2010
- Author(s)
  長嶋一昭
- Total Pages
  4
- Publisher
  ライフサイエンス出版
- Data Source
  KAKENHI-PROJECT-19591047
[Book] インスリン分泌における KATP チャネルの役割. 糖尿病ナビゲーター(第2版)2010
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-22590977
[Book] インスリン分泌促進薬2009
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  日本内科学会雑誌
- Data Source
  KAKENHI-PROJECT-19591047
[Book] 日本内科学会雑誌2009
- Author(s)
  長嶋一昭
- Total Pages
  5
- Publisher
  社団法人日本内科学会
- Data Source
  KAKENHI-PROJECT-19591047
[Book] 糖尿病ナビゲーター2009
- Author(s)
  長嶋一昭
- Total Pages
  2
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-19591047
[Book] 特集:糖尿病治療薬Up to Date. 2. インスリン分泌促進薬の作用機序とトピックス(インスリン分泌調節機構、新生児糖尿病を含めて)2009
- Author(s)
  田中大祐、長嶋一昭、稲垣暢也
- Publisher
  医学出版
- Data Source
  KAKENHI-PROJECT-19591047
[Book] 内分泌・糖尿病科2008
- Author(s)
  長嶋一昭
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-19591047
[Book] KATPチャネルを介するインスリン分泌機構, 日本臨床増刊新時代の糖尿病学(1)-病因・診断・治療研究の進歩-第2版2008
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-19591047
[Book] 新生児糖尿病の成因と治療2008
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  協和企画
- Data Source
  KAKENHI-PROJECT-19591047
[Book] 日本臨床増刊新時代の糖尿病学(1)-病因・診断・治療研究の進歩-第2版2008
- Author(s)
  長嶋一昭
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-19591047
[Book] 種々のSU薬の相違点内分泌・糖尿病科2008
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-19591047
[Book] Diabetes Journal2008
- Author(s)
  長嶋一昭
- Publisher
  協和企画
- Data Source
  KAKENHI-PROJECT-19591047
[Book] 最新医学2007
- Author(s)
  長嶋一昭
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-19591047
[Book] 新生児糖尿病治療の新展開-スルホニル尿素薬の有効性-2007
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-19591047
[Book] Diabetes Frontier2007
- Author(s)
  長嶋一昭
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-19591047
[Book] インスリン分泌におけるKATPチャネルの役割, カラー版糖尿病学基礎と臨床2007
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-19591047
[Book] ABCタンパク質の異常と疾患, 血糖調節にかかわるSUR-低血糖症と糖尿病-2007
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-19591047
[Book] 臨床薬剤の糖代謝への影響;抗不整脈薬2007
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-19591047
[Book] カラー版糖尿病学基礎と臨床2007
- Author(s)
  長嶋一昭
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-19591047
[Book] 糖尿病カレントライブラリー(6)2006
- Author(s)
  長嶋一昭, 稲垣暢也
- Total Pages
  239
- Publisher
  分光堂
- Data Source
  KAKENHI-PROJECT-16790508
[Book] インスリン分泌促進薬2006
- Author(s)
  長嶋一昭, 稲垣暢也
- Total Pages
  120
- Publisher
  フジメディカル出版
- Data Source
  KAKENHI-PROJECT-16790508
[Book] 糖尿病カレントライブラリー4 糖尿病と遺伝子2005
- Author(s)
  長嶋一昭, 他
- Total Pages
  3
- Publisher
  分光堂
- Data Source
  KAKENHI-PROJECT-15GS0301
[Book] Diabetes Frontier 16(5) ATP感受性K^+チャネル.2005
- Author(s)
  長嶋一昭, 他.
- Total Pages
  5
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-16790508
[Book] K_<ATP>チャネルによるインスリン分泌と糖尿病別冊医学のあゆみ「イオンチャネルの最前線」2005
- Author(s)
  長嶋一昭, 他.
- Total Pages
  6
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-16790508
[Book] Surgery Frontier K_<ATP>チャネルと血糖調節2005
- Author(s)
  長嶋一昭, 他.
- Total Pages
  4
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-16790508
[Book] 別冊・医学のあゆみK_<ATP>チャンネルによるインスリン分泌と糖尿病.イオンチャネル最前線update2005
- Author(s)
  長嶋一昭, 他
- Total Pages
  5
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-15GS0301
[Book] 糖尿病カレントライブラリー(4) 糖尿病と遺伝子遺伝子異常による血糖異常;Kir6.22005
- Author(s)
  長嶋一昭, 他.
- Total Pages
  4
- Publisher
  分光堂
- Data Source
  KAKENHI-PROJECT-16790508
[Book] 内分泌・糖尿病科2004
- Author(s)
  長嶋一昭, 稲垣暢也
- Total Pages
  5
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-16790508
[Book] 稲垣暢也. SU 薬とインクレチン関連薬併用による低血糖. 経口糖尿病治療薬の新展開-病態プロファイルと最適薬剤選択の決め手
- Author(s)
  長嶋一昭、稲垣暢也
- Publisher
  フジメディカル出版
- Data Source
  KAKENHI-PROJECT-22590977
[Journal Article] Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model2020
- Author(s)
  Tatsuoka H, Sakamoto S, Yabe D, Kabai R, Kato U, Okumura T, Botagarova A, Tokumoto S, Usui R, Ogura M, Nagashima K, Mukai E, Fujtani Y, Watanabe A, Inagaki N
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 12 Pages: 101774-101774
- DOI
  10.1016/j.isci.2020.101774
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09021, KAKENHI-PROJECT-20K21616, KAKENHI-PROJECT-20K17531, KAKENHI-PROJECT-20H03463, KAKENHI-PROJECT-16K09746, KAKENHI-PROJECT-18H02826, KAKENHI-PROJECT-19H03217
[Journal Article] GPR40 activation initiates store-operated Ca2+ entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells2019
- Author(s)
  Usui R, Yabe D, Fauzi M, Goto H, Botagarova A, Tokumoto S, Tatsuoka H, Tahara Y, Kobayashi S, Manebe T, Baba Y, Kurosaki T, Herrera PL, Ogura M, Nagashima K, Inagaki N
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Issue: 1 Pages: 15562-15562
- DOI
  10.1038/s41598-019-52048-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09746, KAKENHI-PROJECT-19K06901, KAKENHI-PROJECT-19K09021, KAKENHI-PROJECT-19K22537, KAKENHI-PROJECT-19K23966, KAKENHI-PUBLICLY-19H04876, KAKENHI-PROJECT-19H01028, KAKENHI-PROJECT-18H02626, KAKENHI-PROJECT-19H03321, KAKENHI-PROJECT-17K09825, KAKENHI-PROJECT-18K19447
[Journal Article] Src regulates insulin secretion and glucose metabolism by influencing subcellular localization of glucokinase in pancreatic β-cells.2016
- Author(s)
  Sato H, Nagashima K, Ogura M, Sato Y, Tahara Y, Ogura K, Yamano G, Sugizaki K, Fujita N, Tatsuoka H, Usui R, Mukai E, Fujimoto S, Inagaki N.
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 7 Issue: 2 Pages: 171-178
- DOI
  10.1111/jdi.12407
- NAID
  120005770743
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461330, KAKENHI-PROJECT-25461346, KAKENHI-PROJECT-25293210, KAKENHI-PROJECT-16H05326
[Journal Article] Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β cell mass via epigenetic modification of Cdkn1c.2015
- Author(s)
  Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Kawada Y, Bartolome A, Hashimoto N, Matsuda T, Koyanagi-Kimura M, Kanno A, Hirota Y, Hosooka T, Nagashima K, Nishimura W, Inoue H, Matsumoto M, Higgins MJ, Yasuda K, Inagaki N, Seino S, Kasuga M, Kido Y.
- Journal Title
  
  Proceedings of the National Acaddemy of Scienceof the United States of America
  
  Volume: 112(27) Issue: 27 Pages: 8332-8337
- DOI
  10.1073/pnas.1422104112
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461351, KAKENHI-PROJECT-26461382, KAKENHI-PUBLICLY-15H01373, KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-15H04851, KAKENHI-PROJECT-25461346, KAKENHI-PROJECT-25461352, KAKENHI-PROJECT-26670599, KAKENHI-PROJECT-26282022
[Journal Article] インスリン分泌機構とその破綻2015
- Author(s)
  長嶋一昭、稲垣暢也
- Journal Title
  
  医学のあゆみ
  
  Volume: 252 Pages: 377-382
- Data Source
  KAKENHI-PROJECT-25461346
[Journal Article] BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis2014
- Author(s)
  Beguin P, Nagashima K, Mahalakshmi RN, Vigot R, Matsunaga A, Miki T, Ng MY, Ng YJ, Lim CH, Tay HS, Hwang LA, Firsov D, Tang BL, Inagaki N, Mori Y, Seino S, Launey T, Hunziker W
- Journal Title
  
  J Cell Biol
  
  Volume: 205 Issue: 2 Pages: 233-249
- DOI
  10.1083/jcb.201304101
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-25293210, KAKENHI-PROJECT-25461346, KAKENHI-PLANNED-26111004
[Journal Article] Palmitate induces reactive oxygen species production andβ-cell dysfunction by activating NADPH oxidase via Src signaling2014
- Author(s)
  Sato Y, Fujimoto S, Mukai E, Sato H, Tahara Y, Ogura K, Yamano G, Ogura M, Nagashima K, Inagaki N
- Journal Title
  
  J Diabetes Investig
  
  Volume: 5 Issue: 1 Pages: 19-26
- DOI
  10.1111/jdi.12124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591308, KAKENHI-PROJECT-25461330, KAKENHI-PROJECT-25461346
[Journal Article] Glucose-stimulated single pancreatic islets sustain increased cytosolic ATP levels during initial Ca2+ influx and subsequent Ca2+ oscillations2013
- Author(s)
  Tanaka T, Nagashima K, Inagaki N, Kioka H, Takashima S, Fukuoka H, Noji H, Kakizuka A and Imamura H
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Issue: 4 Pages: 2205-2216
- DOI
  10.1074/jbc.m113.499111
- NAID
  120005689188
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23115002, KAKENHI-PROJECT-23249016, KAKENHI-PROJECT-24657101, KAKENHI-PROJECT-25251016, KAKENHI-PROJECT-25461346, KAKENHI-PLANNED-26111004
[Journal Article] Exome sequencing identifies a new candidate mutation for susceptibility to diabetes in a family with highly aggregated type 2 diabetes2013
- Author(s)
  Tanaka D, Nagashima K, Sasaki M, Funakoshi S, Kondo Y, Yasuda K, Koizumi A, Inagaki N
- Journal Title
  
  Mol. Genet. Metabol.
  
  Volume: 109(1) Issue: 1 Pages: 112-117
- DOI
  10.1016/j.ymgme.2013.02.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249020, KAKENHI-PROJECT-22390185, KAKENHI-PROJECT-22590977, KAKENHI-PROJECT-23659329
[Journal Article] Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity.2013
- Author(s)
  Suzuki K, Harada N, Yamane S, Nakamura Y, Sasaki K, Nasteska D, Joo E, Shibue K, Harada T, Hamasaki A, Toyoda K, Nagashima K, Inagaki N.
- Journal Title
  
  J Biol Chem.
  
  Volume: 288 Issue: 3 Pages: 1929-1938
- DOI
  10.1074/jbc.m112.423137
- NAID
  120005373090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390185, KAKENHI-PROJECT-22590975, KAKENHI-PROJECT-22590976, KAKENHI-PROJECT-22590977, KAKENHI-PROJECT-25293210, KAKENHI-PROJECT-25461344, KAKENHI-PROJECT-25461345, KAKENHI-PROJECT-25461878
[Journal Article] Reduction of reactive oxygen species ameliorates metabolism-secretion coupling in islets of diabetic GK rats by suppressing lactate overproduction2013
- Author(s)
  Sasaki M, Fujimoto S, Sato Y, Nishi Y, Mukai E, Yamano G, Sato H, Tahara Y, Ogura K, Nagashima K, Inagaki N
- Journal Title
  
  Diabetes
  
  Volume: 62 Issue: 6 Pages: 1996-2003
- DOI
  10.2337/db12-0903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590977, KAKENHI-PROJECT-23591308, KAKENHI-PROJECT-25293210, KAKENHI-PROJECT-25461330, KAKENHI-PROJECT-25461346, KAKENHI-PROJECT-25670258
[Journal Article] 新生児糖尿病2012
- Author(s)
  長嶋一昭, 他
- Journal Title
  
  International Review of Diabetes
  
  Volume: (印刷中)
- Data Source
  KAKENHI-PROJECT-22590977
[Journal Article] その他の特定の機序、疾患による糖尿病2011
- Author(s)
  長嶋一昭, 他
- Journal Title
  
  内分泌・糖尿病・代謝内科
  
  Pages: 44-52
- Data Source
  KAKENHI-PROJECT-22590977
[Journal Article] 新生児糖尿病2011
- Author(s)
  長嶋一昭, 他
- Journal Title
  
  月刊糖尿病
  
  Pages: 58-64
- Data Source
  KAKENHI-PROJECT-22590977
[Journal Article] 糖尿病の新しい診断基準.その他の特定の機序、疾患による糖尿病2011
- Author(s)
  長嶋一昭, 他
- Journal Title
  
  内分泌・糖尿病・代謝内科
  
  Volume: 31 Pages: 44-52
- Data Source
  KAKENHI-PROJECT-22590977
[Journal Article] 糖尿病とイオンチャネル2011
- Author(s)
  長嶋一昭, 他
- Journal Title
  
  細胞
  
  Pages: 420-423
- Data Source
  KAKENHI-PROJECT-22590977
[Journal Article] GCKR mutations in Japanese families with clustered type 2 diabetes2011
- Author(s)
  Tanaka D, Nagashima K, Sasaki M, Yamada C, Funakoshi S, Akitomo K, Takenaka K, Harada K, Koizumi A, M, Inagaki N
- Journal Title
  
  Mol. Genet. Metab
  
  Volume: 102 Issue: 4 Pages: 453-460
- DOI
  10.1016/j.ymgme.2010.12.009
- NAID
  120002970864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590977
[Journal Article] DPP-4阻害薬の現状と展望2010
- Author(s)
  長嶋一昭, 他
- Journal Title
  
  臨床栄養
  
  Volume: 117 Pages: 753-757
- Data Source
  KAKENHI-PROJECT-22590977
[Journal Article] Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism2010
- Author(s)
  Shimodahira M, Fujimoto S, Mukai E, Nakamura Y, Nishi Y, Sasaki M, Sato Y, Sato H, Hosokawa M, Nagashima K, Seino Y, Inagaki N.
- Journal Title
  
  J Endocrinol 204(1)
  
  Pages: 37-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591047
[Journal Article] Ketosis-Prone糖尿病緩解期における経静脈的糖負荷のインスリン分泌への影響について2010
- Author(s)
  長嶋一昭, 他
- Journal Title
  
  International Review of Diabetes
  
  Volume: 2 Pages: 140-141
- Data Source
  KAKENHI-PROJECT-22590977
[Journal Article] Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species2010
- Author(s)
  Fujita Y, Hosokawa M, Fujimoto S, Mukai E, Abudukadier A, Obara A, Ogura M, Nakamura Y, Toyoda K, Nagashima K, Seino Y, Inagaki N.
- Journal Title
  
  Diabetologia (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591047
[Journal Article] 新たに取り上げられた遺伝子異常による糖尿病2010
- Author(s)
  長嶋一昭, 他
- Journal Title
  
  月刊糖尿病
  
  Volume: 2 Pages: 68-73
- Data Source
  KAKENHI-PROJECT-22590977
[Journal Article] Nuclear transport of Kir/Gem requires specific signals, importin a5 and is regulated by calmodulin and predicted serine phosphorylations2007
- Author(s)
  Mahalakshmi RN, Nagashima K, Ng MY, Inagaki N, Hunziker W, Beguin P.
- Journal Title
  
  Traffic 8(9)
  
  Pages: 1150-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591047
[Journal Article] Sulfonylurea and glinide reduce insulin content, functional expression of K (ATP) channels, and accelerate2007
- Author(s)
  Takahashi A, Nagashima K, et al.
- Journal Title
  
  Diabetes Res Clin Pract (in press)
- Data Source
  KAKENHI-PROJECT-16790508
[Journal Article] Sulfonylurea and glinide reduce insulin content, functional expression of KATP channels, and accelerate apoptotic β-cell death in the chronic phase2007
- Author(s)
  Takahashi A, Nagashima K, Hamasaki A, Kuwamura N, Kawasaki Y, Ikeda H, Yamada Y, Inagaki N, Seino Y.
- Journal Title
  
  Diabetes Res Clin Pract 77(3)
  
  Pages: 343-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591047
[Journal Article] Adult pancreatic islets require differential pax6 gene dosage.2007
- Author(s)
  Hamasaki A, Yamada Y, Kurose T, Ban N, Nagashima K, et al.
- Journal Title
  
  Biochem Biophys Res Commun 353(1)
  
  Pages: 40-46
- Data Source
  KAKENHI-PROJECT-16790508
[Journal Article] Gatifloxacin acutely stimulates insulin secretion and chronically suppresses insulin biosynthesis.2006
- Author(s)
  Yamada C, Nagashima K, et al.
- Journal Title
  
  Eur J Pharmacol. 553(1-3)
  
  Pages: 67-72
- Data Source
  KAKENHI-PROJECT-16790508
[Journal Article] Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion.2006
- Author(s)
  Kawaguchi M, Minami K, Nagashima K, et al.
- Journal Title
  
  J Biol Chem. 281(19)
  
  Pages: 13015-13020
- Data Source
  KAKENHI-PROJECT-16790508
[Journal Article] The C42R mutastron in the Kir6.2(KCNJ11) gene as a cause of transient neonatal diabetes, childhood diabetes, or later-onset, apparently type 2 diabetes mellitus.2005
- Author(s)
  Yorifuji, T, Nagashima, K, kurokawa, K., Mamada, M., Kawai, M., Oishi, M., Akazawa, Y., Hosokawa, M., Yamada, Y, Inagaki, N., Nakahata, T.
- Journal Title
  
  J. Clin. Endocr. Metab. 90
  
  Pages: 3174-3178
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15GS0301
[Journal Article] The C42R mutation in the Kir6.2 (KCNJ11) gene as a cause of transient neonatal diabetes, childhood diabetes, or later-onset, apparently type 2 diabetes mellitus.2005
- Author(s)
  Yorifuji T, Nagashima K, et al.
- Journal Title
  
  J Clin Endocrinol Metab. 90(6)
  
  Pages: 3174-3178
- Data Source
  KAKENHI-PROJECT-16790508
[Journal Article] Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G protein Rem2.2005
- Author(s)
  Beguin P, Mahalakshmi RN, Nagashima K, et al.
- Journal Title
  
  Biochem J. 390(1)
  
  Pages: 67-75
- Data Source
  KAKENHI-PROJECT-16790508
[Journal Article] Direct inhibition of the interaction between AID and BID of voltage-dependent Ca2+ channels by Gem.2005
- Author(s)
  Saaki T, Shibasaki T, Beguin P, Nagashima K, et al.
- Journal Title
  
  J Biol Chem. 280(10)
  
  Pages: 9308-9312
- Data Source
  KAKENHI-PROJECT-16790508
[Journal Article] Cdk5-dependent regulation of glucose-stimulated insulin secretion.2005
- Author(s)
  Wei FY, Nagashima K, et al.
- Journal Title
  
  Nature Med. 11(10)
  
  Pages: 1104-1108
- NAID
  130005447816
- Data Source
  KAKENHI-PROJECT-16790508
[Journal Article] The C42R mutation in the Kir6.2(KCNJ11)gene as a cause of transient neonatal diabetes, childhood diabetes, or later-onset, apparently type 2 diabetes mellitus2005
- Author(s)
  Yorifuji, T., Nagashima.K., Kurokawa, K., Mamada, M., Kawai, M., Oishi, M., Akazawa, Y., Hosokawa, M., Yamada, Y., Inagaki, N., and Nakahata, T.
- Journal Title
  
  J.Clin.Endocr.Metab. 90
  
  Pages: 3174-3178
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15GS0301
[Journal Article] 14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity.2005
- Author(s)
  Beguin P, Mahalakshmi RN, Nagashima K, et al.
- Journal Title
  
  J Cell Sci. 118
  
  Pages: 1923-1934
- Data Source
  KAKENHI-PROJECT-16790508
[Journal Article] Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action.2005
- Author(s)
  Zhou H, Yamada Y, Tsukiyama K, Miyawaki K, Hosokawa M, Nagashima K, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 335(3)
  
  Pages: 937-942
- Data Source
  KAKENHI-PROJECT-16790508
[Journal Article] GIP is the Major Insulinotropic Factor in K_<ATP> Null Mice.2004
- Author(s)
  Tsukiyama K, Yamada Y, Miyawaki K, Hamasaki A, Nagashima K et al.
- Journal Title
  
  Eur J Endocrinol 151(3)
  
  Pages: 407-412
- Data Source
  KAKENHI-PROJECT-16790508
[Journal Article] Sulfonylurea and non-sulfonylurea hypoglycemic agents : pharmachological properties and tissue slectivity2004
- Author(s)
  Nagashima K, Takahashi A, Ikeda H, et al.
- Journal Title
  
  Diabetes Res Clin Pract 66(S1)
- Data Source
  KAKENHI-PROJECT-16790508
[Presentation] Store-operated Ca2+ entry activated by STIM1 plays an essential role in GPR40-mediated GIIS potentiation2019
- Author(s)
  Usui R, Yabe D, Fauzi M, Goto H, Botagarova A, Tokumoto S, Tatsuoka H, Tahara Y, Kobayashi S, Manabe T, Baba Y, Kurosaki T, Ogura M, Nagashima K, Inagaki N
- Organizer
  American Diabetes Association the 79th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09746
[Presentation] ER Ca2+ sensor, stromal interaction molecule 1 (STIM1) plays an important role in GPR40-mediated potentiation of glucose-induced insulin secretion.2018
- Author(s)
  Usui R, Yabe D, Goto H, Fauzi M, Botagarova A, Tokumoto S, Tatsuoka H, Tahara Y, Ogura M, Nagashima K, Inagaki N
- Organizer
  Asian Islet Biology and Incretin 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09746
[Presentation] The role of ER Ca2+sensor, stromal interaction molecule 1 (STIM1) in GPR40-mediated potentiation of glucose-induced insulin secretion.2018
- Author(s)
  Usui R, Yabe D, Goto H, Fauzi M, Tokumoto S, Tatsuoka H, Tahara Y, Ogura M, Nagashima K, Inagaki N
- Organizer
  54th Annual Meeting of the European Association for the Study of Diabetes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09746
[Presentation] ATP and Ca2+ dynamics in pancreatic β-cells:Ex vivo analysis using ATP biosensor GO-ATeam12017
- Author(s)
  Usui R, Yabe D, Fauzi M,Tokumoto S, Tatsuoka H, Tahara Y, Ogura M, Nagashima K, Inagaki N.
- Organizer
  The 9th Scientific Meeting of the Asian Association for the Study of Diabetes (AASD)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09746
[Presentation] Genetic and epigenetic programs for regenerating pancreatic beta-cells following partial pancreatectomy in mice2017
- Author(s)
  Tatsuoka H, Nakamura M, Yabe D, Usui R, Muhammad F, Tokumoto S, Tahara Y, Ogura M, Nagashima K, Watanabe A, Inagaki N
- Organizer
  Kyoto Diabetes Mini-Symposium: Beta Cell Replacement Strategies.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09746
[Presentation] 蛍光ATPプローブ遺伝子ノックインマウスを用いた膵β細胞内代謝解析2016
- Author(s)
  杉崎和, 山本正道, 龍岡久登, 臼井亮太, 今村博臣, 田原裕美子, 小倉かさね, 佐藤広規, 佐藤雄一, 小倉雅仁, 長嶋一昭, 稲垣暢也.
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K09746
[Presentation] 新生児糖尿病の発症原因遺伝子と機能解析2014
- Author(s)
  長嶋一昭
- Organizer
  51回日本糖尿病学会近畿地方会
- Place of Presentation
  大阪
- Year and Date
  2014-10-25
- Invited
- Data Source
  KAKENHI-PROJECT-25461346
[Presentation] 糖尿病治療における経口血糖降下薬の最近の進歩2014
- Author(s)
  長嶋一昭
- Organizer
  京都府医師会学術講演会
- Place of Presentation
  京都
- Year and Date
  2014-11-15
- Invited
- Data Source
  KAKENHI-PROJECT-25461346
[Presentation] Genetic and functional analyses of KATP channel gene mutations in patients with neonatal diabetes in Japan2013
- Author(s)
  Nagashima K, Yorifuji T, Tanaka D, Inagaki N
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京(船堀)
- Data Source
  KAKENHI-PROJECT-22590977
[Presentation] 蛍光ATPバイオセンサーを用いたインスリン分泌細胞内ATPのダイナミクスの計測2013
- Author(s)
  田中喬, 長嶋一昭, 稲垣暢也, 野地博行, 垣塚彰, 今村博臣.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  神奈川県
- Data Source
  KAKENHI-PROJECT-25461346
[Presentation] Genetic and functional analyses of KATP channel gene mutations in patients with neonatal diabetes in Japan.2013
- Author(s)
  Nagashima K
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22590977
[Presentation] 日本人新生児糖尿病の発症頻度、発症原因遺伝子および遺伝子変異部位による薬効変化に関する検討2012
- Author(s)
  長嶋一昭、佐々木真弓、田中大祐、稲垣暢也
- Organizer
  第55回日本糖尿病学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590977
[Presentation] Molecular analyses of Japanese patients with neonatal diabetes.2012
- Author(s)
  Nagashima K
- Organizer
  9th International Diabetes Federation Western Pacific Region Congress/ 4th Scientific Meeting of the Asian Association for the Study of Diabetes.
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22590977
[Presentation] 蛍光プローブを用いた膵β細胞内ATPおよびCa2+濃度同時測定の試み.2012
- Author(s)
  長嶋一昭
- Organizer
  第55回日本糖尿病学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590977
[Presentation] 蛍光プローブを用いた膵 β細胞内 ATP および Ca^<2+>濃度同時測定の試み2012
- Author(s)
  長嶋一昭、今村博臣、田中喬、田中大祐、稲垣暢也
- Organizer
  第55回日本糖尿病学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590977
[Presentation] Molecular analyses of Japanese patients with neonatal diabetes2012
- Author(s)
  Nagashima K, Yorifuji T, Sasaki M, Tanaka D, Ogura K, Sato H, Tahara Y, Yamano G, Sato Y, Sugizaki K, Ogura M, Inagaki N
- Organizer
  9th International Diabetes Federation Western Pacific Region Congress/ 4th Scientific Meeting of the Asian Association for the Study of Diabetes
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22590977
[Presentation] Functional analysis of KCNJ11 mutation in neonatal diabetes2011
- Author(s)
  Nagashima K, Tohru Yorifuji T, Sasaki M, Tanaka D, Inagaki N
- Organizer
  3th Asian Association for the Study ofDiabetes (AASD)
- Place of Presentation
  北京(中国)
- Data Source
  KAKENHI-PROJECT-22590977
[Presentation] 本邦における新生児糖尿病発症頻度および発症原因遺伝子に関する検討2011
- Author(s)
  長嶋一昭, 他
- Organizer
  第54回日本糖尿病学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590977
[Presentation] Functional analysis of KCNJ11 mutation in neonatal diabetes2011
- Author(s)
  Nagashima K, et al
- Organizer
  3th Asian Association for the study of Diabetes
- Place of Presentation
  北京(中国)
- Data Source
  KAKENHI-PROJECT-22590977
[Presentation] 本邦における新生児糖尿病発症頻度に関する全国アンケート調査2010
- Author(s)
  長嶋一昭, 他
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-22590977
[Presentation] 脂質異常症を合併した2型糖尿病患者2010
- Author(s)
  細川雅也、浜崎暁洋、藤本新平、長嶋一昭、原島伸一、藤田義人、豊田健太郎、山田千積、原田範雄、幣憲一郎、稲垣暢也
- Organizer
  第13回日本病態栄養学会年次学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] 新規電位依存性Ca2+チャネル調節因子の同定および膵β細胞インスリン分泌調節への影響に関する検討2009
- Author(s)
  長嶋一昭, Pascal Beguin, Walter Hunziker, 稲垣暢也
- Organizer
  第52回日本糖尿病学会総年次学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] A P1198L mutation in ABCC8 gene decreases ATP sensitivity of the KATP channel and causes permanent neonatal diabetes2009
- Author(s)
  Takagi T, Furuta H, Miyawaki M, Nagashima K, Nishi M, Sasaki H, Inagaki N, Yoshikawa N, Nanjo K.
- Organizer
  The 11th Symposium on Molecular Diabetology in Asia
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2009-12-19
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] 2型糖尿病候補遺伝子KCNQ1の膵β細胞に及ぼす役割の検討2009
- Author(s)
  渋谷由紀、木戸良明、淺原俊一郎、松田友和、竹田章彦、井上妙、小柳真希、長嶋一昭、清野進、春日雅人
- Organizer
  第52回日本糖尿病学会総年次学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] 代謝調節機構解析に基づく細胞機能制御基盤技術2009
- Author(s)
  山野言、長嶋一昭、藤本新平、稲垣暢也
- Organizer
  第2回公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] Kir6.2遺伝子異常糖尿病での遺伝子変異部位の違いによる薬剤反応性変化についての比較検討2008
- Author(s)
  長嶋一昭
- Organizer
  第51回日本糖尿病学会
- Place of Presentation
  東京都千代田区
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] Kir6. 2遺伝子異常糖尿病の遺伝子変異部位による薬剤反応性変化に関する検討2008
- Author(s)
  長嶋一昭、佐々木真弓、中村靖彦、桑村尚充、河崎祐貴子、稲垣暢也
- Organizer
  第3回トランスポーター研究会年会
- Place of Presentation
  京都
- Year and Date
  2008-06-08
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] インスリン分泌と栄養シグナルに関する検討2008
- Author(s)
  長嶋一昭
- Organizer
  シンポジウム糖尿病
- Place of Presentation
  東京
- Year and Date
  2008-04-19
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] Kir6. 2遺伝子異常糖尿病での遺伝子変異部位の違いによる薬剤反応性変化についての比較検討2008
- Author(s)
  長嶋一昭、佐々木真弓、中村靖彦、桑村尚充、河崎祐貴子、稲垣暢也
- Organizer
  第51回日本糖尿病学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] インスリン分泌と栄養シグナルに関する検討2008
- Author(s)
  長嶋一昭
- Organizer
  シンポジウム糖尿病
- Place of Presentation
  東京都千代田区
- Year and Date
  2008-04-19
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] Kir6.2遺伝子異常糖尿病の遺伝子変異部位による薬剤反応性変化に関する検討2008
- Author(s)
  長嶋一昭
- Organizer
  第3回トランスポーター研究会年会
- Place of Presentation
  京都府京都市
- Year and Date
  2008-06-08
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] Diversity of the pharmacological profile in oral insulinotropic agents.2007
- Author(s)
  Nagashima K
- Organizer
  14th Japan-Korea Symposium on DiabetesMellitus
- Place of Presentation
  京都府京都市
- Year and Date
  2007-10-06
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] Diversity of the pharmacological profile in oral insulinotropic agents2007
- Author(s)
  Nagashima K.
- Organizer
  14th Japan-Korea Symposium on Diabetes Mellitus
- Place of Presentation
  Kyoto
- Year and Date
  2007-10-06
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] HMG-CoA還元酵素阻害薬(スタチン)による潜在的膵β細胞インスリン分泌抑制作用に関する検討2007
- Author(s)
  長嶋一昭、桑村尚充、常宝成、高橋輝、河崎祐貴子, 山田祐一郎, 清野裕、稲垣暢也
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] HMG-CoA還元酵素阻害薬(スタチン)による潜在的膵β細胞インスリン分泌抑制作用に関する検討2007
- Author(s)
  長嶋一昭
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2007-05-26
- Data Source
  KAKENHI-PROJECT-19591047
[Presentation] Chronic Administration of Apple Procyanidins Ameliorate Insulin Resistance through the suppression of inflammation in Diabetic ob/ob Mice.
- Author(s)
  Ogura K, Nagashima K, Shoji T, Sato Y, Tahara Y, Yamano G, Sato H, Sugizaki K, Fujita N, Ogura M, Mukai E, Fujimoto S, Inagaki N.
- Organizer
  American Diabetes Association(ADA) 72nd Scientific Sessions (ADA)
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-06-13 – 2014-06-17
- Data Source
  KAKENHI-PROJECT-25461346

1. IMAMURA Hiromi (20422545)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. Mori Yasuo (80212265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. FUJIMOTO Shimpei (00333576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. INAGAKI Nobuya (30241954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. UEDA Kazumitsu (10151789)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KATO Hiroaki (90204487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMADA Katsuya (40241666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 井原裕 (50322160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 黒瀬健 (90264374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 笹川貴代 (10254567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 矢部大介 (60378643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 坂信広 (90333921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAGAMATSU go

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAKUBO keiyo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MORI masayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KUROKAWA tatsuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SAKAGUCHI reiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TOYODA Kentarou

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. NISHIMURA Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 向英里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 野地博行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 小泉昭夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 清野進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 小倉雅仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagashima Kazuaki 長嶋 一昭

NAGASHIMA Kazuaki 長嶋 一昭

Research Projects

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Metabolic and functional analysis of pancreatic islet cells using the fluorescent ATP probe gene knock-in mousePrincipal Investigator

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Molecular physiological studies of in vivo hypoxia niche: formation, sensing and adaptation

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Functional analysis of pancreatic beta-cells in metabolic disorders using the fluorescent ATP probe gene transgenic mousePrincipal Investigator

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Real-time measurement of intracellular ATP concentration using novel fluorescent ATP probe.Principal Investigator

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Mutations in genes encoding the K_<ATP> channel and their influence on efficacy of insulinotropic agents.Principal Investigator

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in silico 膵β細胞およびα細胞の機能的統合モデルの構築Principal Investigator

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Molecular Basis of Novel Membrane Transport Mechanism

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酸化ストレスに基づく膵β細胞障害のシグナル伝達経路の解明

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インスリン分泌促進薬の薬理特性、および結合部位に基づくクラス分類の試みPrincipal Investigator

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The mechanism of glucose-induced time-dependent potentiation of insulin secretion from pancreatic β cells and its alteration in diabetic state

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[Book] 食後高血糖の病態から各経口薬の特徴と併用療法の実際をみる2013

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[Book] スルホニル尿素薬. 糖尿病の分子標的と治療薬辞典2013

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[Book] 新生児糖尿病. International Review of Diabetes2012

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[Book] SU 薬と速効型インスリン分泌促進薬. 糖尿病学イラストレイテッド2012

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Nagashima Kazuaki 長嶋一昭

NAGASHIMA Kazuaki 長嶋一昭