Mese Hiroshi 目瀬浩

… Alternative Names

目瀬浩メセヒロシ

MESE Hiroshi 目瀬浩

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Researcher Number	40325098
Other IDs
Affiliation (Current)	2025: 岡山大学, 歯学部, 客員研究員
Affiliation (based on the past Project Information) *help	2012: 岡山大学, 医歯(薬)学総合研究科, 准教授 2007: Okayama University, GRADUATE SCHOOL OF MEDICINE, DENTISTRY AND PHARMACEUTICAL SCIENCES, ASSOCIATE PROFESSOR 2005 – 2006: OKAYAMA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, DENTISTRY AND PHARMACEUTICAL SCIENCES, ASSOCIATE PROFESSOR, 大学院・医歯薬学総合研究科, 助教授 2003 – 2004: OKAYAMA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE AND DENTISTRY, ASSOCIATE PROFESSOR, 大学院・医歯学総合研究科, 助教授 2002: OKAYAMA UNIVERSITY, DENTAL SCHOOL, LECTURER, 歯学部附属病院, 講師 2001: Okayama University, GRADUATE SCHOOL OF MEDICINE AND DENTISTRY, INSTRUCTOR, 大学院・医歯学総合研究科, 助手 2000: 岡山大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Surgical dentistry / Surgical dentistry Except Principal Investigator Surgical dentistry / Surgical dentistry
Keywords	Principal Investigator 固形癌内部環境 / CDDP(シスプラチン)耐性 / HIF-1α / DNAミスマッチ修復 / ヌクレオチド除去修復 / glucose-starved stress / stress conditions in solid tumors / CDDP (Cisplatin) resistance / Caspase-3 / SAPK … More / JNK1 / Glucose-regulated proteins (GRPs) / グルコース飢餓 / DNA修復機構 / 低酸素環境 / DNA repair mechanism / hvnoxia / solid cancer internal environment / CDDP (Cisnlatin) resistance / グルコース飢餓環境 / NIF-1α / シスプラチン(CDDP)耐性 / DNA mismatch repair (MMR) / nucleotide excision repair (NER) / hypoxia / 低酸素 / Apoptosis / CCDP(シスプラチン)耐性 / Glicose-regulated proteins(GRPs) / アポトーシス / ERCC1 / シスプラチン（CDDP）耐性 … More Except Principal Investigator 口腔扁平上皮癌 / 口腟扁平上皮癌 / methionine aminopeptidase-2 / 分子標的治療 / oral squamous cell carcinoma / VEGF-C / PD-ECGF / VEGF / angiogenesis inhibitor / TNP-470 / 血管新生阻害剤 / 高カルシウム血症 / oral squamous cell carsinoma / doc-1 / microarray / transfection / bone destruction / bone invasion / siRNA / osteoclastic bone resorption / 遺伝子 / 高カルシウム / 遺伝子発現 / 血管新生 / 骨破壊 / マイクロアレイ / si RNA / 破骨細胞性骨吸収 / Cisplatin(CDDP) / HIF-1 α / molecular target therapy / hypoxia / stress conditions solid tumors / 低酸素環境 / シスプラチン(CDDP) / HIF-1α / 低酸素 / 固形癌内部環境 / angiogenic factor / tumor suppressor gene p16 and p53 / 脱メチル化剤 / 遺伝子導入 / 癌抑制遺伝子p16 / 血管新生因子 / 癌抑制遺伝子p53及びp16 / PTHrP / bone disease / bone resorption / hypercalcemia / osteoclast / 血管新生障害剤 / 副甲状腺ホルモン関連蛋白 / 骨代謝性疾患 / 骨吸収 / 破骨細胞 / metastasis / invasion / tumor suppressor gene / efficacy / gene therapy / oral cancer / アデノウイルスベクター / 非ウイルスベクター / 口腟癌 / 浸潤・転移 / 癌抑制遺伝子 / 導入効率 / 遺伝子治療 / 口腔癌 Less

Research Projects
(9 results)
Co-Researchers
(8 People)

固形癌特有の低酸素環境に依存するシスプラチン耐性機構の検討Principal Investigator
- Principal Investigator
  
  目瀬浩
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Okayama University
ANALYSIS OF CISPLATIN RESISTANT TARGET FACTOR UNDER STRESS CONDITIOS IN SOLID TUMORPrincipal Investigator
- Principal Investigator
  
  MESE Hiroshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Okayama University
ANALYSIS OF CISPLATIN RESISTANT TARGET FACTOR UNDER STRESS CONDITIOS IN SOLID TUMORPrincipal Investigator
- Principal Investigator
  
  MESE HIROSHI
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  OKAYAMA UNIVERSITY
Investigation of mechanism of methionine aminopeptidase-2 as a molecular target against cancer-induced bone destruction
- Principal Investigator
  
  SASAKI Akira
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  OKAYAMA UNIVERSITY
ANALYSIS OF APOPTOSIS INDUCED MOLECULAR TARGET THERAPY OF CISPLATIN RESISTANT TUMOR UNDER STRESS CONDITIONSPrincipal Investigator
- Principal Investigator
  
  MESE Hiroshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  OKAYAMA UNIVERSITY
INVESTIGATION OF HIF-1α TARGET MOLECULE THERAPY OF SOLID TUMORUNDER STRESS CONDITIONS
- Principal Investigator
  
  MATSUMURA Tomohiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  OKAYAMA UNIVERSITY
EXPERIMENTAL STUDY OF MECHANISM OF ANGIOGENESIS INHIBITOR, TNP-470 ON THE BONE METABOLISM AND CLINICAL APPROACH FOR HUMORAL HYPERCALCEMIA OF MARIGNANCY.
- Principal Investigator
  
  SASAKI Akira
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  OKAYAMA UNIVERSITY
STUDY OF TUM0R SUPPRESSOR GENE AND ANGIOGENESIS IN ORAL CAJNCER -Effect of the transfection of p53 and p16 tumor suppressor genes on angiogenesis-.
- Principal Investigator
  
  KISHIMOTO Koji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  OKAYAMA UNIVERSITY
EXPERIMENTAL STUDY OF GENE THERAPY FOR ORAL CANCER USING A TUMOR SUPPRESSOR GENE DOC-1.
- Principal Investigator
  
  MATSUMURA Tomohiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  OKAYAMA UNIVERSITY

1. SASKI Akira (00170663)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. MATSUMURA Tomohiro (00028747)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KISHIMOTO Koji (40243480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SHIMO Tsuyoshi (40362991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 伊原木聰一郎 (80549866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大山和彦 (20169080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 新谷悟 (80294429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KUSAKA Masami

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Mese Hiroshi 目瀬 浩

目瀬 浩 メセ ヒロシ

MESE Hiroshi 目瀬 浩

Research Projects

Co-Researchers

固形癌特有の低酸素環境に依存するシスプラチン耐性機構の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ANALYSIS OF CISPLATIN RESISTANT TARGET FACTOR UNDER STRESS CONDITIOS IN SOLID TUMORPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ANALYSIS OF CISPLATIN RESISTANT TARGET FACTOR UNDER STRESS CONDITIOS IN SOLID TUMORPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of mechanism of methionine aminopeptidase-2 as a molecular target against cancer-induced bone destruction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ANALYSIS OF APOPTOSIS INDUCED MOLECULAR TARGET THERAPY OF CISPLATIN RESISTANT TUMOR UNDER STRESS CONDITIONSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

INVESTIGATION OF HIF-1α TARGET MOLECULE THERAPY OF SOLID TUMORUNDER STRESS CONDITIONS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

EXPERIMENTAL STUDY OF MECHANISM OF ANGIOGENESIS INHIBITOR, TNP-470 ON THE BONE METABOLISM AND CLINICAL APPROACH FOR HUMORAL HYPERCALCEMIA OF MARIGNANCY.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

STUDY OF TUM0R SUPPRESSOR GENE AND ANGIOGENESIS IN ORAL CAJNCER -Effect of the transfection of p53 and p16 tumor suppressor genes on angiogenesis-.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

EXPERIMENTAL STUDY OF GENE THERAPY FOR ORAL CANCER USING A TUMOR SUPPRESSOR GENE DOC-1.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mese Hiroshi 目瀬浩

目瀬浩メセヒロシ

MESE Hiroshi 目瀬浩