Kojima Hirotada 小島裕正

… Alternative Names

小島裕正コジマヒロタダ

KOJIMA Hirotada 小島裕正

Less

Researcher Number	40336772
Other IDs
Affiliation (Current)	2025: 大阪公立大学, 大学院医学研究科, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 大阪公立大学, 大学院医学研究科, 講師 2015 – 2020: 大阪市立大学, 大学院医学研究科, 講師 2013 – 2014: 大阪市立大学, 医学(系)研究科(研究院), 講師 2011: 大阪市立大学, 大学院・医学研究科, 講師 2011: 大阪市立大学, 大学院医学研究科, 助教 2007 – 2011: Osaka City University, 大学院・医学研究科, 助教
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 48040:Medical biochemistry-related / Pathological medical chemistry Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Chemistry related to living body
Keywords	Principal Investigator サイトカイン / シグナル伝達 / がん / 亜急性硬化性全脳炎 / 麻疹ウイルス / 細胞内情報伝達 / 細胞老化 / 癌 / 分子標的療法 / プロテオーム / 免疫 / 細胞医科学 … More Except Principal Investigator … More 亜急性硬化性全脳炎 / 麻疹ウイルス / ウイルス / アイソフォーム1と2 / 抗がん剤 / Fas / スプラーシング制御 / S1-1 nuclear body targeting sequence / 核移行配列 / がん危険遺伝子 / アポトーシス関連遺伝子 / 転写制御 / スプライシング制御 / RBM10 / S1-1 / プロセシング / RNA Less

麻疹ウイルスH蛋白の変異による神経病原性および受容体利用能の変化Principal Investigator
- Principal Investigator
  
  小島裕正
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka Metropolitan University
麻疹ウイルスH蛋白の変異による神経病原性およびレセプター利用能の変化
- Principal Investigator
  
  綾田稔
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka Metropolitan University
がん発症過程における炎症性サイトカインによるRBM10リン酸化の意義の解明Principal Investigator
- Principal Investigator
  
  小島裕正
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Osaka City University
Development of a novel treatment for neuroviral infections using an experimental measles virus infection system as a model
- Principal Investigator
  
  AYATA Minoru
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka City University
Role of STAT3 in cytokine-induced senescencePrincipal Investigator
- Principal Investigator
  
  Kojima Hirotada
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka City University
The splicing factor and diseases caused by its anomaly
- Principal Investigator
  
  INOUE Akira
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Osaka City University
Mechanism of cytokine-induced cellular senescencePrincipal Investigator
- Principal Investigator
  
  KOJIMA Hirotada
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka City University
Molecular mechanism for the regulation of NLKPrincipal Investigator
- Principal Investigator
  
  KOJIMA Hirotada
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka City University

All 2021 2017 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] Tumor Dormancy and Cellular Quiescence and Senescence, Cancer, and Noncancer Pathologies : Interleukin-6 Induces Premature Senescence Involving the STAT3 and Insulin-Like Growth Factor-Binding Protein 52013
- Author(s)
  Kojima H, Kunimoto H, Inoue T, Nakajima K.Aging
- Publisher
  (in press)
- Data Source
  KAKENHI-PROJECT-21590316
[Journal Article] Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition.2014
- Author(s)
  Suematsu T, Li Y, Kojima H, Nakajima K, Oshimura M, Inoue T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 3 Pages: 588-594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460392
[Journal Article] SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors.2014
- Author(s)
  Inoue T, Nakayama Y, Li Y, Matsumori H, Takahashi H, Kojima H, Wanibuchi H, Katoh M, Oshimura M.
- Journal Title
  
  FEBS J.
  
  Volume: 11 Pages: 2623-2637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460392
[Journal Article] S1-1/RBM10: Multiplicity and cooperativity of nuclear localisation domains.2013
- Author(s)
  Xiao SJ, Wang LY, Kimura M, Kojima H　.et al.
- Journal Title
  
  Biol Cell.
  
  Volume: 105 Pages: 162-174
- Data Source
  KAKENHI-PROJECT-25460392
[Journal Article] IL-6-STAT3 signaling and premature senescence.2013
- Author(s)
  Kojima H, Inoue T, Kunimoto H, Nakajima K.
- Journal Title
  
  JAKSTAT
  
  Volume: 2 Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460392
[Journal Article] The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts2012
- Author(s)
  Kojima H, Kunimoto H, Inoue T, Nakajima K
- Journal Title
  
  Cell Cycle
  
  Volume: 11 Issue: 4 Pages: 730-739
- DOI
  10.4161/cc.11.4.19172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590316, KAKENHI-PROJECT-23570005
[Journal Article] SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis.2011
- Author(s)
  Li Y, Matsumori H, Nakayama Y, Osaki M, Kojima H, Kurimasa A, ItoH, Mori S, Katoh M, Oshimura M, Inoue T.
- Journal Title
  
  Genes Cells.
  
  Volume: 16 Pages: 34-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590316
[Journal Article] SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis2011
- Author(s)
  Li Y, Matsumori H, Nakayama Y, Osaki M, Kojima H,, Kurimasa A, Ito H, Mori S, Katoh M, Oshimura M, Inoue T
- Journal Title
  
  Genes Cells
  
  Volume: 16 Issue: 1 Pages: 34-45
- DOI
  10.1111/j.1365-2443.2010.01460.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590316
[Journal Article] Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphory-lation of phospho-Tyr705 largely through TC452011
- Author(s)
  Ryohei Wakahara, Hiroyuki Kunimoto, Kanae Tanino, Hirotada Kojima, Akira Inoue, Haruo Shintaku and Koichi Nakajima
- Journal Title
  
  Genes to Cells
  
  Volume: 17 Issue: 2 Pages: 132-145
- DOI
  10.1111/j.1365-2443.2011.01575.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21550162, KAKENHI-PROJECT-21590316, KAKENHI-PROJECT-21590317
[Journal Article] 【サイトカインと疾患 : あらたな病態モデルから治療へ】サイトカインシグナル伝達機構 JAK-STATの標準経路と非標準経路モデル2010
- Author(s)
  中嶋弘一, 小島裕正
- Journal Title
  
  医学のあゆみ
  
  Volume: 234(5) Pages: 325-330
- Data Source
  KAKENHI-PROJECT-21590316
[Presentation] Regulation of interferon signaling by the V proteins from the Osaka-1 and Osaka-2 SSPE strains of measles virus2021
- Author(s)
  小島裕正、綾田稔
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-16K09994
[Presentation] RBM10の活動度を制御する自己調節機構：S1-1 NB-targeting2017
- Author(s)
  井上晃、國本浩之、王凌宇、肖勝軍、小島裕正
- Organizer
  ConBio2017生命科学系学会合同年会
- Data Source
  KAKENHI-PROJECT-25460392
[Presentation] The role of STAT3 C-terminal region in the regulation of STAT3 stability2014
- Author(s)
  Yang J, Kojima H, Kunimoto H, Nakano S, Nakajima K.
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館 (京都府・京都市)
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-25460392
[Presentation] Phospho-Ser727 of STAT3 shortens the duration of STAT3 activity by enhancing the dephosphorylation of pY705 through nuclear TC452011
- Author(s)
  Wakahara R, Kunimoto H, Kojima H, Nakajima K
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉市
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21590316
[Presentation] Phospho-Ser727 of STAT3 shortens the duration of STAT3 activity by enhancing the dephosphorylation of pY705 through nuclear TC452011
- Author(s)
  Wakahara R, Kunimoto H, Kojima H, Nakajima K
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉市)
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21590316
[Presentation] gp130-Stat3 signaling induces premature cellular senescence2010
- Author(s)
  Kojima H, Kunimoto H, Nakajima K
- Organizer
  第33回日本分子生物学会・第83回日本生化学会大会合同年会
- Place of Presentation
  神戸市
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21590316
[Presentation] Prolonged stimulation of gp130 leads to premature senescence of human diploid fibroblasts2010
- Author(s)
  Kojima H, Kunimoto H, Nakajima K
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-21590316
[Presentation] gp130-Stat3 signaling induces premature cellular senescence2010
- Author(s)
  小島裕正, 國本浩之, 中嶋弘一
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21590316
[Presentation] Prolonged stimulation of gp130 leads to premature senescence of human diploid fibroblasts2010
- Author(s)
  Kojima H, Kunimoto H, Nakajima K
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-21590316
[Presentation] Prolonged stimulation of gp130 leads to premature senescence of human diploid fibroblasts2009
- Author(s)
  Kojima H, Kunimoto H, Nakajima K
- Organizer
  第32回日本分子生物学会年会, パシフィコ横浜
- Place of Presentation
  神奈川県
- Year and Date
  2009-12-17
- Data Source
  KAKENHI-PROJECT-19590284
[Presentation] Prolonged stimulation of gp130 leads to premature senescence of human diploid fibroblasts2009
- Author(s)
  小島裕正
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜 (神奈川)
- Year and Date
  2009-12-17
- Data Source
  KAKENHI-PROJECT-21590316
[Presentation] Prolonged stimulation of gp130 leads to premature senescence of human diploid fibroblasts2009
- Author(s)
  Kojima H, Kunimoto H, Nakajima K
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜市
- Year and Date
  2009-12-17
- Data Source
  KAKENHI-PROJECT-21590316
[Presentation] gp130を介した細胞老化誘導機構の解析2008
- Author(s)
  Kojima H, Nozawa T, Kunimoto H, Nakajima K
- Organizer
  第31回日本分子生物学会・第81回日本生化学会合同年会, 神戸ポートアイランド
- Place of Presentation
  兵庫県
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19590284
[Presentation] Prolonged stimulation of gp130 receptor leads to premature senescence of human diploid fibroblasts.2008
- Author(s)
  小島, 裕正
- Organizer
  BMB 2008
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19590284
[Presentation] S1-1/RBM10: Multiplicity and cooperativity of nuclear localization domains
- Author(s)
  小島裕正
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25460392

1. NAKAJIMA Koichi (00227787)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
2. AYATA Minoru (90222702)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. 井上敏昭 (80305573)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. INOUE Akira (50109857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 瀬戸俊之 (60423878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 桑村充 (20244668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kojima Hirotada 小島 裕正

小島 裕正 コジマ ヒロタダ

KOJIMA Hirotada 小島 裕正

Research Projects

Research Products

Co-Researchers

麻疹ウイルスH蛋白の変異による神経病原性および受容体利用能の変化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

麻疹ウイルスH蛋白の変異による神経病原性およびレセプター利用能の変化

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

がん発症過程における炎症性サイトカインによるRBM10リン酸化の意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel treatment for neuroviral infections using an experimental measles virus infection system as a model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of STAT3 in cytokine-induced senescencePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The splicing factor and diseases caused by its anomaly

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of cytokine-induced cellular senescencePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism for the regulation of NLKPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Tumor Dormancy and Cellular Quiescence and Senescence, Cancer, and Noncancer Pathologies : Interleukin-6 Induces Premature Senescence Involving the STAT3 and Insulin-Like Growth Factor-Binding Protein 52013

Author(s)

Publisher

Data Source

[Journal Article] Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition.2014

Author(s)

Journal Title

Data Source

[Journal Article] SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors.2014

Author(s)

Journal Title

Data Source

[Journal Article] S1-1/RBM10: Multiplicity and cooperativity of nuclear localisation domains.2013

Author(s)

Journal Title

Data Source

[Journal Article] IL-6-STAT3 signaling and premature senescence.2013

Author(s)

Journal Title

Data Source

[Journal Article] The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis.2011

Kojima Hirotada 小島裕正

小島裕正コジマヒロタダ

KOJIMA Hirotada 小島裕正