Kinoshita Ichiro 木下一郎

… Alternative Names

KINOSHITA Ichiro 木下一郎

Less

Researcher Number	40343008
Other IDs
External Links
Affiliation (Current)	2025: 北海道大学, 大学病院, 教授
Affiliation (based on the past Project Information) *help	2019 – 2025: 北海道大学, 大学病院, 教授 2017 – 2018: 北海道大学, 医学研究院, 准教授 2016: 北海道大学, 医学研究科, 准教授 2012 – 2015: 北海道大学, 医学(系)研究科(研究院), 准教授 2014: 北海道大学, 大学院医学研究科, 准教授 … More 2012: 北海道大学, 大学院・医学研究科, 准教授 2011: 北海道大学, 医学(系)研究科(研究院), 講師 2007 – 2010: 北海道大学, 大学院・医学研究科, 講師 2006: Hokkaido University, Graduate SChool of Medicine, Lecturer, 大学院医学研究科, 講師 2004 – 2005: 北海道大学, 大学院・医学研究科, 講師 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor diagnosis
Keywords	Principal Investigator 肺癌 / EZH2 / HDAC / c-jun / AP-1 / EGFR / ヒストン修飾酵素 / ヒストン修飾 / 分子標的薬 / エピジェネティクス … More / 幹細胞 / 癌幹細胞 / cJun / 転写因子 / 治療効果予測 / 分子標的治療 / 遺伝子再構成 / オンコジェニックドライバー融合遺伝子 / 包括的がんゲノムプロファイリング検査 / CDK4/6 / KDM5 / Everolimus / 固形がん / everolimus / MTOR / CDK4/6 inhibitor / HDAC inhibitor / SMARCA4 / SWI/SNF / 抗癌薬耐性 / エピゲノム / 薬剤耐性 / PBIT / JARID1 / 脱メチル化酵素 / transformation / transcription factor / molecular biology / gene therapy / lung cancer / トランスフォーメーション / 分子生物学 / 遺伝子治療 / 非小細胞肺癌 / side population / SAHA / DZNep / ｃJun / mcm4 / 癌遺伝子 / インテグリンα6 / 癌 / 遺伝子 / マイクロアレイ / MCM4 / 分子標的 … More Except Principal Investigator 肺癌 / 非小細胞肺癌 / 免疫チェックポイント阻害薬 / 小細胞肺癌 / AKR1B10 / α1,6-フコース転移酵素 / 糖転移酵素 / irAE / CD73 / トリプルネガティブ / 効果予測 / がん免疫療法 / Tumor mutational burden / SWI/SNF複合体遺伝子 / 治療効果予測バイオマーカー / 免疫チェックポイント阻害薬(ICI) / SWI/SNF変異 / 治療標的 / Prox1 / Numbの機能 / Numb / 組織系 / 肺扁平上皮癌 / 肺腺癌 / EGFR mutation / biomarker / lung cancer / タバコ発癌 / 扁平上皮癌 / 喫煙 / EGF受容体遺伝子変異 / 分子マーカー / フェルスター共鳴エネルギー移動 / バイオイメージング / FRETバイオセンサー / 薬剤耐性 / EGFR-TKI / 国際情報交換 / Lung cancer / Bcl2 family / Ｂｉｍ / Ｎｏｔｃｈ / Notch / 併用治療効果 / alfa1,6-フコース転移酵素 / alfa 1-6フコース転移酵素 / 糖転移酵素〓1-6fucosyltransferase / 糖鎖 / バイオマーカー Less

Frequency of driver gene rearrangements forming functional fusion genes and therapeutic targetability in solid tumorsPrincipal Investigator
- Principal Investigator
  
  木下一郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Hokkaido University
小細胞肺癌におけるmidkineを標的とした汎用性の高い治療開発の検討
- Principal Investigator
  
  榊原純 (小西純)
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hokkaido University
免疫関連因子CD73のトリプルネガティブ乳癌周術期治療効果・有害事象との関連性の検討
- Principal Investigator
  
  高橋將人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hokkaido University
A Study on Predicting the Effectiveness of Cancer Immunotherapy
- Principal Investigator
  
  菊地順子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Hokkaido University
小細胞肺癌におけるProx1によるNotch pathwayの制御機構、治療開発
- Principal Investigator
  
  榊原純 (小西純)
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hokkaido University
Optimization of treatment strategy with EZH2 inhibitor for solid cancer with SWI/SNF alterationPrincipal Investigator
- Principal Investigator
  
  Kinoshita Ichiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Hokkaido University
Numb has distinct roles in lung adenocarcinoma and squamous cell carcinomaus us
- Principal Investigator
  
  sakakibara jun
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hokkaido University
Development of potential therapy using histone modifying enzyme inhibitor to overcome drug resistance of non-small lung cancerPrincipal Investigator
- Principal Investigator
  
  Kinoshita Ichiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Combined inhibition of stem cell markers and histone modification enzymes in non-small cell lung cancerPrincipal Investigator
- Principal Investigator
  
  Kinoshita Ichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Study on EGFR-TKI resistance using FRET biosensor
- Principal Investigator
  
  Akita Hirotoshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Combined antitumor effec ot g-secretase inbitiro and ABT-737
- Principal Investigator
  
  SAKAKIBARA Jun
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Targeted therapy for cancer stem-like cells of non-small cell lung cancers with inhibition of the cJun transcription factorPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Ichiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Alteration of fucosylation and biomarker development in lung cancer
- Principal Investigator
  
  AKITA Hirotoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnosis
- Research Institution
  Hokkaido University
Identification of novel molecular targets for lung cancer based on different sensitivity to AP-1 blockadePrincipal Investigator
- Principal Investigator
  
  KINOSHITA Ichiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
肺癌および随伴肺疾患における糖転移酵素の発現異常に関する研究
- Principal Investigator
  
  AKITA Hirotoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Research on Molecular Therapeutic Targets and Biomarkers for the Diagnosis and Stratification in Lung Cancer
- Principal Investigator
  
  AKITA Hirotoshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Growth inhibition of non-small cell lung cancer cells by AP-1 blockade using a cJun dominant negative mutant, TAM67Principal Investigator
- Principal Investigator
  
  KINOSHITA Ichiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  HOKKAIDO UNIVERSITY

[Journal Article] EGFR inhibition in EGFR-mutant lung cancer cells perturbs innate immune signaling pathways in the tumor microenvironment.2023
- Author(s)
  Shiiya A, Noguchi T, Tomaru U, Ariga S, Takashima Y, Ohhara Y, Taguchi J, Takeuchi S, Shimizu Y, Kinoshita I, Koizumi T, Matsuno Y, Shinagawa N, Sakakibara-Konishi J, Dosaka-Akita H
- Journal Title
  
  Cancer Sci
  
  Volume: 114 Issue: 4 Pages: 1270-1283
- DOI
  10.1111/cas.15701
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07691, KAKENHI-PROJECT-23K24099
[Journal Article] Effect of comprehensive cancer genomic profiling on therapeutic strategies and clinical outcomes in patients with advanced biliary tract cancer: A prospective multicenter study2022
- Author(s)
  Takada Kohichi、Kubo Tomohiro、Kikuchi Junko
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 12 Pages: 99-99
- DOI
  10.3389/fonc.2022.988527
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08080, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-20H03655, KAKENHI-PROJECT-20K07691
[Journal Article] Clinical significance of comprehensive genomic profiling tests covered by public insurance in patients with advanced solid cancers in Hokkaido, Japan2021
- Author(s)
  Kikuchi Junko、Ohhara Yoshihito、Takada Kohichi、Kinoshita Ichiro
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: - Issue: 5 Pages: 753-761
- DOI
  10.1093/jjco/hyaa277
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08397, KAKENHI-PROJECT-20K07691, KAKENHI-PROJECT-19K09818
[Journal Article] Impact of clinical targeted sequencing on endocrine responsiveness in estrogen receptor-positive, HER2-negative metastatic breast cancer2021
- Author(s)
  Hagio K, Amano T, Hayashi H, Takeshita T, Oshino T, Kikuchi J, Ohhara Y, Yabe I, Kinoshita I, Nishihara H, Yamashita H
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 8109-8109
- DOI
  10.1038/s41598-021-87645-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07691
[Journal Article] Pharmacokinetics, safety, and efficacy of trastuzumab deruxtecan with concomitant ritonavir or itraconazole in patients with HER2-expressing advanced solid tumors2021
- Author(s)
  Takahashi S, Karayama M, Takahashi M, Watanabe J, Minami H, Yamamoto N, Kinoshita I, Lin CC, Im YH, Achiwa I, Kamiyama E, Okuda Y, Lee C, Bang YJ
- Journal Title
  
  Clin Cancer Res
  
  Volume: 27 Issue: 21 Pages: 5771-5780
- DOI
  10.1158/1078-0432.ccr-21-1560
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07691
[Journal Article] Expression of the immunoproteasome subunit β5i in non-small cell lung carcinomas2020
- Author(s)
  Kiuchi Takayuki、Tomaru Utano、Ishizu Akihiro、Imagawa Makoto、Iwasaki Sari、Suzuki Akira、Otsuka Noriyuki、Ohhara Yoshihito、Kinoshita Ichiro、Matsuno Yoshihiro、Dosaka-Akita Hirotoshi、Kasahara Masanori
- Journal Title
  
  Journal of Clinical Pathology
  
  Volume: 74 Issue: 5 Pages: 300-306
- DOI
  10.1136/jclinpath-2020-206618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07691, KAKENHI-PROJECT-20K21512, KAKENHI-PROJECT-18H02629
[Journal Article] Evaluating the immunoproteasome as a potential therapeutic target in cisplatin-resistant small cell and non-small cell lung cancer2020
- Author(s)
  Shoji T, Kikuchi E, Kikuchi J, Takashima Y, Furuta M, Takahashi H, Tsuji K, Maeda M, Kinoshita I, Dosaka-Akita H, Sakakibara-Konishi J, Konno S
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: in print Issue: 5 Pages: 843-853
- DOI
  10.1007/s00280-020-04061-9
- NAID
  120007032615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-18K08130, KAKENHI-PROJECT-19K23876, KAKENHI-PROJECT-19K23903
[Journal Article] Bromodomain and extraterminal domain inhibition synergizes with WEE1‐inhibitor AZD1775 effect by impairing nonhomologous end joining and enhancing DNA damage in nonsmall cell lung cancer2020
- Author(s)
  Takashima Yuta、Kikuchi Eiki、Kikuchi Junko、Suzuki Motofumi、Kikuchi Hajime、Maeda Makie、Shoji Tetsuaki、Furuta Megumi、Kinoshita Ichiro、Dosaka‐Akita Hirotoshi、Sakakibara‐Konishi Jun、Konno Satoshi
- Journal Title
  
  International Journal of Cancer
  
  Volume: 146 Issue: 4 Pages: 1114-1124
- DOI
  10.1002/ijc.32515
- NAID
  120006958367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-18K08130, KAKENHI-PROJECT-19K23876
[Journal Article] Clinical impact of a cancer genomic profiling test using an in‐house comprehensive targeted sequencing system2020
- Author(s)
  Hayashi Hideyuki、Tanishima Shigeki、Fujii Kyoko、Mori Ryo、Okada Chihiro、Yanagita Emmy、Shibata Yuka、Matsuoka Ryosuke、Amano Toraji、Yamada Takahiro、Yabe Ichiro、Kinoshita Ichiro、Komatsu Yoshito、Dosaka‐Akita Hirotoshi、Nishihara Hiroshi
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 10 Pages: 3926-3937
- DOI
  10.1111/cas.14608
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07691, KAKENHI-PROJECT-17K15910
[Journal Article] DLL3 regulates the migration and invasion of small cell lung cancer by modulating Snail2019
- Author(s)
  Furuta Megumi、Kikuchi Hajime、Shoji Tetsuaki、Takashima Yuta、Kikuchi Eiki、Kikuchi Junko、Kinoshita Ichiro、Dosaka‐Akita Hirotoshi、Sakakibara‐Konishi Jun
- Journal Title
  
  Cancer Science
  
  Volume: in print Issue: 5 Pages: 1599-1608
- DOI
  10.1111/cas.13997
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-18K08130
[Journal Article] A phase II study of carboplatin, pemetrexed, and bevacizumab followed by erlotinib and bevacizumab maintenance for non-squamous non-small cell lung cancer with wild-type EGFR (HOT1101)2018
- Author(s)
  Takashina T, Asahina H, Oizumi S, Yamada N, Harada M, Takamura K, Yokouchi H, Harada T, Honjo O, Ogi T, Morikawa N, Kinoshita I, Honda R, Nakano K, Kanazawa K, Amano T, Dosaka-Akita H, Isobe H, Nishimura M
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 23 Issue: 6 Pages: 1060-1069
- DOI
  10.1007/s10147-018-1318-z
- NAID
  120006651802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09639
[Journal Article] Updated survival outcomes of NEJ005/TCOG0902: a randomised phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations.2018
- Author(s)
  Oizumi S, Sugawara S, Minato K, Harada T, Inoue A, Fujita Y, Maemondo M, Watanabe S, Ito K, Gemma A, Demura Y, Fukumoto S, Isobe H, Kinoshita I, Morita S, Kobayashi K, Hagiwara K, Aiba K, Nukiwa T.
- Journal Title
  
  ESMO Open
  
  Volume: 3(2) Issue: 2 Pages: e000313-e000313
- DOI
  10.1136/esmoopen-2017-000313
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09562, KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-15K09164, KAKENHI-PROJECT-15K09168, KAKENHI-PROJECT-15K09237
[Journal Article] Numb has distinct function in lung adenocarcinoma and squamous cell carcinoma2018
- Author(s)
  Kikuchi Hajime、Sakakibara-Konishi Jun、Furuta Megumi、Kikuchi Eiki、Kikuchi Junko、Oizumi Satoshi、Hida Yasuhiro、Kaga Kichizo、Kinoshita Ichiro、Dosaka-Akita Hirotoshi、Nishimura Masaharu
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 50 Pages: 29379-29391
- DOI
  10.18632/oncotarget.25585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-18K08130
[Journal Article] Clinicopathologic Features and Immune Microenvironment of Non?Small-cell Lung Cancer With Primary Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors2018
- Author(s)
  Takashima Yuta、Sakakibara-Konishi Jun、Hatanaka Yutaka、Hatanaka Kanako C.、Ohhara Yoshihito、Oizumi Satoshi、Hida Yasuhiro、Kaga Kichizo、Kinoshita Ichiro、Dosaka-Akita Hirotoshi、Matsuno Yoshihiro、Nishimura Masaharu
- Journal Title
  
  Clinical Lung Cancer
  
  Volume: 19 Issue: 4 Pages: 352-359
- DOI
  10.1016/j.cllc.2018.02.004
- NAID
  120006649179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09639
[Journal Article] Combined antitumor effect of γ-secretase inhibitor and ABT-737 in Notch-expressing non-small cell lung cancer2017
- Author(s)
  Sakakibara-Konishi J, Ikezawa Y, Oizumi S, Kikuchi J, Kikuchi E, Mizugaki H, Kinoshita I, Dosaka-Akita H, Nishimura M
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 22 Issue: 2 Pages: 481-487
- DOI
  10.1007/s10147-016-1060-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461175
[Journal Article] A randomized phase II trial of erlotinib vs. S-1 as a third- or fourth-line therapy for patients with wild-type EGFR non-small cell lung cancer (HOT1002)2017
- Author(s)
  Ikezawa Y, Asahina H, Oizumi S, Watanabe M, Takamura K, Kawai Y, Yamada N, Harada T, Kinoshita I, Fujita Y, Miyauchi E, Ogi T, Amano T, Furuta M, Sakakibara-Konishi J, Nishihara H, Dosaka-Akita H, Isobe H, Nishimura M; Hokkaido Lung Cancer Clinical Study Group
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 80 Issue: 5 Pages: 955-963
- DOI
  10.1007/s00280-017-3432-4
- NAID
  120006533131
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-15K09164
[Journal Article] A phase II study of bevacizumab with carboplatin-pemetrexed in non-squamous non-small cell lung carcinoma patients with malignant pleural effusions: North East Japan Study Group Trial NEJ013A.2016
- Author(s)
  Usui K, Sugawara S, Nishitsuji M, Fujita Y, Inoue A, Mouri A, Watanabe H, Sakai H, Kinoshita I, Ohhara Y, Maemondo M, Kagamu H, Hagiwara K, Kobayashi K
- Journal Title
  
  Lung Cancer
  
  Volume: 99 Pages: 131-136
- DOI
  10.1016/j.lungcan.2016.07.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293196, KAKENHI-PROJECT-26461175
[Journal Article] Combined inhibition of EZH2 and HDACs as a potential epigenetic therapy for non-small cell lung cancer cells2016
- Author(s)
  Takashina T, Kinoshita I, Kikuchi J, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Nishimura M, and Dosaka-Akita H
- Journal Title
  
  Cancer Sci
  
  Volume: （in press）
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461175
[Journal Article] Novel signaling collaboration between TGF-beta and adaptor protein Crk facilitates EMT in human lung cancer2016
- Author(s)
  Elmansuri AZ, Tanino MA, Mahabir R, Wang L, Kimura T, Nishihara H, Kinoshita I, Dosaka-Akita H, Tsuda M and Tanaka S
- Journal Title
  
  Oncotarget
  
  Volume: （in press） Issue: 19 Pages: 27094-107
- DOI
  10.18632/oncotarget.8314
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-15K15106, KAKENHI-PROJECT-25460471, KAKENHI-PROJECT-26670414, KAKENHI-PROJECT-15K08359, KAKENHI-PROJECT-16K08703
[Journal Article] The coordinated actions of TIM-3 on cancer and myeloid cells in the regulation of tumorigenicity and clinical prognosis in clear cell renal cell carcinomas2015
- Author(s)
  Komohara Y, Morita T, Annan DA, Horlad H, Ohnishi K, Yamada S, Nakayama T, Kitada S, Suzu S, Kinoshita I, Dosaka-Akita H, Akashi K, Takeya M, Jinushi M
- Journal Title
  
  Cancer Immunol Res
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461175
[Journal Article] Randomized phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations: NEJ005/TCOG0902.2015
- Author(s)
  Sugawara S, Oizumi S, Minato K, Harada T, Inoue A, Fujita Y, Maemondo M, Yoshizawa H, Ito K, Gemma A, Nishitsuji M, Harada M, Isobe H, Kinoshita I, Morita S, Kobayashi K, Hagiwara K, Kurihara M, Nukiwa T; North East Japan Study Group and Tokyo Cooperative Oncology Group
- Journal Title
  
  Ann Oncol.
  
  Volume: 26(5) Issue: 5 Pages: 888-94
- DOI
  10.1093/annonc/mdv063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-15K09164
[Journal Article] Factors associated with a poor response to gefitinib in the NEJ002 study: Smoking and the L858R mutation.2015
- Author(s)
  Fukuhara T, Yoshizawa H et al.
- Journal Title
  
  Lung Cancer
  
  Volume: 88 Issue: 2 Pages: 181-6
- DOI
  10.1016/j.lungcan.2015.02.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591156, KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-15K09164, KAKENHI-PROJECT-15K09237, KAKENHI-PROJECT-15K15320
[Journal Article] Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers2015
- Author(s)
  Honma R, Kinoshita I, Miyoshi E, Tomaru U, Matsuno Y, Shimizu Y, Takeuchi S, Kobayashi Y, Kaga K, Taniguchi N, Dosaka-Akita H
- Journal Title
  
  Oncology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461175
[Journal Article] CD133 expression: a potential prognostic marker for non-small cell lung cancers2014
- Author(s)
  Mizugaki H, Sakakibara-Konishi J, Kikuchi J, Moriya J, Hatanaka KC, Kikuchi E, Kinoshita I, Oizumi S, Dosaka-Akita H, Matsuno Y and Nishimura M
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 19 Issue: 2 Pages: 254-259
- DOI
  10.1007/s10147-013-0541-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591132
[Journal Article] Cancer stem-like cells derived from chemoresistant tumors have a unique capacity to prime tumorigenic myeloid cells.2014
- Author(s)
  Yamashina T, Baghdadi M, Yoneda A, Kinoshita I, Suzu S, Dosaka-Akita H, Jinushi M.
- Journal Title
  
  Cancer Research
  
  Volume: 74 Issue: 10 Pages: 2698-2709
- DOI
  10.1158/0008-5472.can-13-2169
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23591132, KAKENHI-PUBLICLY-25112701, KAKENHI-PUBLICLY-25130701, KAKENHI-PROJECT-26290050, KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-26670183
[Journal Article] Updated Overall Survival Results from A Randomized Phase III Trial Comparing Gefitinib with Carboplatin-Paclitaxel for Chemo-Naive Non-Small Cell Lung Cancer with Sensitive EGFR Gene Mutations (NEJ002)2013
- Author(s)
  Inoue A, Kobayashi K, Maemondo M, et al
- Journal Title
  
  Ann Oncol
  
  Volume: 24 Issue: 1 Pages: 54-9
- DOI
  10.1093/annonc/mds214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790746, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-24240042, KAKENHI-PROJECT-24591156, KAKENHI-PROJECT-24591184, KAKENHI-PROJECT-24659396
[Journal Article] TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance.2013
- Author(s)
  Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M
- Journal Title
  
  Immunity
  
  Volume: 39 Issue: 6 Pages: 1070-1081
- DOI
  10.1016/j.immuni.2013.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-24790479, KAKENHI-PUBLICLY-25112701, KAKENHI-PUBLICLY-25130701, KAKENHI-PROJECT-25293089, KAKENHI-PROJECT-25461503
[Journal Article] Expression of Bim, Noxa, and Puma in non-small cell lung cancer.2012
- Author(s)
  Sakakibara-Konishi J, Oizumi S, Kikuchi J, Kikuchi E, Mizugaki H, Kinoshita I, Dosaka-Akita H, Nishimura M
- Journal Title
  
  BMC Cancer.
  
  Volume: 12 Issue: 1 Pages: 286-286
- DOI
  10.1186/1471-2407-12-286
- NAID
  120004756336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591146
[Journal Article] Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells2012
- Author(s)
  Kikuchi J, Takashina T, Kinoshita I, Kikuchi E, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Marquez VE, Nishimura M, Dosaka-Akita H
- Journal Title
  
  Lung Cancer
  
  Volume: 78 Issue: 2 Pages: 138-143
- DOI
  10.1016/j.lungcan.2012.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591132
[Journal Article] ATM-mediated DNA damage signals mediate immune escape through integrin αvβ3-dependent mechanisms.2012
- Author(s)
  Jinushi M
- Journal Title
  
  Cancer Res
  
  Volume: 72 Issue: 1 Pages: 56-65
- DOI
  10.1158/0008-5472.can-11-2028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390113, KAKENHI-PROJECT-21689031, KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132
[Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. S.2012
- Author(s)
  Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J. V. Gorman, J. D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi.
- Journal Title
  
  Nat. Immunol.
  
  Volume: 13 Issue: 9 Pages: 832-842
- DOI
  10.1038/ni.2376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04616, KAKENHI-PROJECT-21390113, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390090, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-23659196, KAKENHI-PUBLICLY-23114501
[Journal Article] Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer2011
- Author(s)
  Kikuchi J, Kinoshita I, Shimizu Y, Kikuchi E, Takeda K, Aburatani H, Oizumi S, Konishi J, Kaga K, Matsuno Y, Birrer MJ, Nishimura M and Dosaka-Akita H
- Journal Title
  
  Lung Cancer
  
  Volume: 72 Issue: 2 Pages: 229-237
- DOI
  10.1016/j.lungcan.2010.08.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591132
[Journal Article] Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis2011
- Author(s)
  Takeda K, Kinoshita I, Shimizu Y, Matsuno Y, Shichinohe T and Dosaka-Akita H
- Journal Title
  
  Anticancer Res
  
  Volume: 31 Pages: 263-270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591132
[Journal Article] Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.2011
- Author(s)
  Kikuchi J, Kinoshita I, Birrer MJ, Dosaka-Akita H
- Journal Title
  
  Lung Cancer. 72
  
  Pages: 229-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590909
[Journal Article] Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells2011
- Author(s)
  Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H, Yagita H, Takaoka A, Tahara H.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 108巻 Issue: 30 Pages: 12425-30
- DOI
  10.1073/pnas.1106645108
- NAID
  10030575946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249069, KAKENHI-PROJECT-21689031, KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132
[Journal Article] Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.2010
- Author(s)
  Kikuchi J, Kinoshita I, et.al.
- Journal Title
  
  Lung Cancer
  
  Volume: 172(9月(Epub))
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590909
[Journal Article] Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance.2010
- Author(s)
  Kikuchi J, Kinoshita I, Dosaka-Akita H
- Journal Title
  
  Cancer 116
  
  Pages: 3015-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590909
[Journal Article] Distinctive expression of the polycomb group proteins Bmil polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance.2010
- Author(s)
  Kikuchi J, Kinoshita I, et.al.
- Journal Title
  
  Cancer
  
  Volume: 116 Pages: 3015-3024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590909
[Journal Article] Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells.2008
- Author(s)
  Kikuchi J, Kinoshita I, Birrer MJ, Dosaka-Akita H
- Journal Title
  
  Br J Cancer 99(12)
  
  Pages: 2013-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590909
[Journal Article] 肺癌の遺伝子異常2004
- Author(s)
  木下一郎, 他
- Journal Title
  
  呼吸と循環 52・10
  
  Pages: 1059-1064
- Data Source
  KAKENHI-PROJECT-16590729
[Presentation] The Predictive Potential of Comprehensive SWI/SNF Gene Analysis in Immunotherapy for Malignant Melanoma2024
- Author(s)
  杢里花, 野口卓郎 , 菊地順子 , 有賀伸, 木下一郎
- Organizer
  日本臨床腫瘍学会総会
- Data Source
  KAKENHI-PROJECT-22K07292
[Presentation] TRK融合陽性の消化器がん患者におけるラロトレクチニブの長期有効性と安全性2022
- Author(s)
  木下一郎, Garralda Elena, Hong David S., Xu Ruihua, Deeken John, Italiano Antonine, Liu Tianshu, Calvo Ferrandiz Aitana, Patel Jyoti D., Lee Dae Ho, Norenberg Ricarda, Burcoveanu Domnita-Ileana, Mussi Chiara E., Drilon Alexander, Shen Li
- Organizer
  第60会日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07691
[Presentation] TRK融合陽性の消化器がん患者におけるラロトレクチニブの有効性と安全性2021
- Author(s)
  木下一郎, Boni Valentina, Drilon Alexander, Deeken John F., Cabanas Elena G., Chung Hyun C., Oh Do-Youn, Patel Jyoti D., Xu Ruihua, Norenberg Ricarda, Brega Nicoletta, Dima Laura, Hong David S., Berlin Jordan
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07691
[Presentation] Clinical sequencing with insurance-covered genomic profiling tests in patients with advanced solid cancers in Hokkaido2021
- Author(s)
  Junko Kikuchi, ‥, Ichiro Kinoshita
- Organizer
  18th Annual Meeting of Japanese Society of Medical Oncology
- Data Source
  KAKENHI-PROJECT-20K07691
[Presentation] CGP 検査前後の患者に対する意思決定支援（がんゲノム医療中核拠点病院）2021
- Author(s)
  木下一郎
- Organizer
  第6 回日本がんサポーティブケア学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07691
[Presentation] JARID1 family inhibitor reduces generation of drug resistant EGFR-mutation positive lung cancer cells2019
- Author(s)
  Ariga S, Kinoshita I, Kikuchi J, Shimizu S, Dosaka-Akita H
- Organizer
  110th Annual Meeting of the American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09639
[Presentation] ヒストン脱メチル化酵素JARID1阻害薬による非小細胞肺癌細胞のEGFR-TKI耐性化の抑制2019
- Author(s)
  有賀伸, 木下一郎, 菊地順子, 清水康, 秋田弘俊,
- Organizer
  第60回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09639
[Presentation] A phase II study of trastuzumab monotherapy in pretreated patients with non-small cell lung cancers (NSCLCs) harboring HER2 alterations: HOT1303-B trial2018
- Author(s)
  Kinoshita I, Goda T, Watanabe K, Maemondo M, Oizumi S, Amano T, Hatanaka Y, Matsuno Y, Nishihara H, Asahina H, Harada T, Goto K, Isobe H, Nishimura M, Dosaka-Akita H
- Organizer
  European Society for Medical Oncology 2018 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09639
[Presentation] DLL3 regulates migration and invasion of Small Cell Lung Cancer2018
- Author(s)
  Megumi Furuta1, Jun Sakakibara-Konishi1, Tetsuaki Shoji1, Yuta Takashima1, Hajime Kikuchi 1, Eiki Kikuchi1, Junko Kikuchi1, Ichiro Kinoshita2, Hirotoshi Dosaka-Akita2, Masaharu Nishimura1
- Organizer
  AACR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08130
[Presentation] JARID1ファミリー阻害薬はEGFR変異陽性肺癌細胞株の薬剤耐性化を緩和する2018
- Author(s)
  有賀伸, 木下一郎, 菊地順子, 清水康, 秋田弘俊
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09639
[Presentation] JARIDファミリー阻害薬の非小細胞肺癌細胞株に対する効果2017
- Author(s)
  有賀伸、木下一郎、菊地順子、清水康、秋田弘俊
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09639
[Presentation] 非小細胞肺癌におけるヒストン修飾酵素阻害療法に関する研究2017
- Author(s)
  木下一郎、秋田弘俊
- Organizer
  第二回北大・部局横断シンポジウム
- Place of Presentation
  北海道大学（北海道・札幌市）
- Invited
- Data Source
  KAKENHI-PROJECT-26461175
[Presentation] EZH2阻害薬とヒストン脱アセチル化酵素（HDAC）阻害薬の併用療法の非小細胞肺癌（NSCLC）細胞に対する抗腫瘍効果2014
- Author(s)
  木下一郎，高階太一、菊地順子、榊原純、大泉聡史、西村正治、秋田弘俊
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  TKPガーデンシティ仙台（宮城県・仙台市）
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-26461175
[Presentation] Prognostic significance of 〓1,6 fucosyltransferase (〓1,6 FT) in non-small cell lung cancers (NSCLCs).2013
- Author(s)
  Honma R, Dosaka-Akita H, Kinoshita I
- Organizer
  2013 Annual Meeting of American Society of Clinical Oncology (ASCO).
- Place of Presentation
  McCormick Place (シカゴ、米国).
- Year and Date
  2013-06-01
- Data Source
  KAKENHI-PROJECT-22501029
[Presentation] Role of polycomb group protein EZH2 in lung cancer2012
- Author(s)
  Kinoshita I
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  教育文化会館, 札幌市
- Year and Date
  2012-09-19
- Invited
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Pharmacologic disruption of polycomb group protein EZH2 via 3-Deazaneplanocin A inhibits growth of non-small cell lung cancer cells2012
- Author(s)
  Kinoshita I
- Organizer
  5th Asia Pacific Lung Cancer Conference
- Place of Presentation
  Hilton Fukuoka Sea Hawk, Fukuoka
- Year and Date
  2012-11-26
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Decreased expression of GMD in non-small cell lung cancers (NSCLCs).2011
- Author(s)
  Honma R, Dosaka-Akita H, Kinoshita I
- Organizer
  102nd Annual Meeting of AmericanAssociation of Cancer Research (AACR).
- Place of Presentation
  Orange CountyConvention Center(オーランド、米国)
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-22501029
[Presentation] Growth inhibition of non-small cell lung cancer cells by the histone methyltransferase ezh2 inhibitor 3-deazaneplanocin2011
- Author(s)
  Kinoshita I
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場, 名古屋市
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Growth inhibition of non-small cell lung cancer cells by the histone methyltransferase ezh2 inhibitor 3-deazaneplanocin2011
- Author(s)
  Kinoshita I
- Organizer
  9th International Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  Hokkaido University, Sapporo
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Growth inhibition of non-small cell lung cancer cells by the histone methyltransferase ezh2 inhibitor 3-deazaneplanocin2011
- Author(s)
  Kinoshita I, Kikuchi J, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Nishimura M, Dosaka-Akita H
- Organizer
  9th International Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  北海道大学（札幌市）
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] GDP-mannose-4,6-dehydratase (GMD) and GDP-fucose transporter in non-small cell lung cancers (NSCLCs) : their decreased expression insquamous cell carcinomas by immunohistochemistry.2011
- Author(s)
  Honma R, Dosaka-Akita H, Kinoshita I
- Organizer
  14th World Conference on Lung Cancer of International Association for the Studyof Lung Cancer.
- Place of Presentation
  Amsterdam RAI(アムステルダム、オランダ)
- Year and Date
  2011-07-05
- Data Source
  KAKENHI-PROJECT-22501029
[Presentation] Growth inhibition of non-small cell lung cancer cells by the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin2011
- Author(s)
  木下一郎，菊地順子，菊地英毅, 清水康, 榊原純, 大泉聡史, 西村正治, 秋田弘俊
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知）
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Decreased expression of GMDand GDP-fucose transporter is associated with squamous histology in NSCLCs.2011
- Author(s)
  Honma R, Dosaka-Akita H, Kinoshita I
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場.
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22501029
[Presentation] Distinctive expression of polycomb group proteins Bmil and EZH2 in nonsmall cell lung cancers and their clinical and clinicopathological significance.2010
- Author(s)
  Kikuchi J, Kinoshita I, et.al.
- Organizer
  101th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Washington Convention Center (Washington, DC, USA)
- Year and Date
  2010-04-20
- Data Source
  KAKENHI-PROJECT-20590909
[Presentation] 非小細胞肺癌におけるポリコーム蛋白質Bmi1とEZH2の発現の違いと臨床病理学的意義2010
- Author(s)
  木下一郎, 他
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20590909
[Presentation] The role of minichromosome maintenance (MCM) protein 4 in proliferation and its clinicopathological significance in non-small cell lung cancers (NSCLCs).2009
- Author(s)
  Kinoshita I.
- Organizer
  13th World Conference of Lung Cancer
- Place of Presentation
  San Francisco, USA
- Year and Date
  2009-08-02
- Data Source
  KAKENHI-PROJECT-20590909
[Presentation] The role of minichromosome maintenance(MCM)protein 4 in proliferation and its clinicopathological significance in non-small cell lung cancers(NSCLCs).2009
- Author(s)
  Kinoshita I, et.al.
- Organizer
  13th World Conference of Lung Cancer
- Place of Presentation
  San Francisco, USA
- Year and Date
  2009-08-03
- Data Source
  KAKENHI-PROJECT-20590909
[Presentation] EZH2阻害薬とヒストン脱アセチル化酵素阻害薬の併用療法の非小細胞肺癌細胞に対する抗腫瘍効果の検討
- Author(s)
  高階太一、木下一郎、菊地順子、池澤靖元、榊原純、大泉聡史、西村正治、秋田弘俊
- Organizer
  第54回日本肺癌学会総会
- Place of Presentation
  ホテルニューオータニ（東京）
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Effects of combined epigenetic therapy with EZH2 and HDAC inhibitors on NSCLC cells
- Author(s)
  Takashina T, Kinoshita I, Kikuchi J, Kikuchi E, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Nishimura M and Dosaka-Akita H
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Role of polycomb group protein EZH2 in lung cancer
- Author(s)
  Kinoshita I
- Organizer
  第71会日本癌学会学術総会
- Place of Presentation
  教育文化会館（札幌市）
- Invited
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Effects of combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin and the histone deacetylase inhibitor SAHA on non-small cell lung cancer cells
- Author(s)
  Takashina T, Kinoshita I, Kikuchi J, Shimizu Y, Konishi JS, Oizumi S, Nishimura M and Dosaka-Akita H
- Organizer
  the 105th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  San Diego Conventon Center (San Diego)
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Pharmacologic disruption of polycomb group protein EZH2 via 3-Deazaneplanocin A inhibits growth of non-small cell lung cancer cells
- Author(s)
  Kinoshita I
- Organizer
  5th Asia Pacific Lung Cancer Conference
- Place of Presentation
  Hilton Fukuoka Sea Hawk (Fukuoka)
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] ヒストンメチル化酵素EZH2阻害剤3-deazaneplanocin Aによる非小細胞肺癌細胞株に対する増殖抑制効果の検討
- Author(s)
  高階太一、木下一郎、菊地順子、菊地英毅、清水康、榊原純、大泉聡史、西村正治、秋田弘俊
- Organizer
  第53回日本肺癌学会総会
- Place of Presentation
  岡山コンベンションセンター（岡山市）
- Data Source
  KAKENHI-PROJECT-23591132

1. AKITA Hirotoshi (70222528)

# of Collaborated Projects: 7 results

# of Collaborated Products: 14 results
2. SAKAKIBARA Jun (50374278)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. 畑中佳奈子 (10399834)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 畑中豊 (30589924)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SHIMIZU Yasushi (10374513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. JINUSHI Masahisa (40318085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. Ohba Yusuke (30333503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YAMAZAKI Koichi (20312358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 三善英知 (20322183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 菊地順子 (40739637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 天野虎次 (20374514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 高橋將人 (50374343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 野口卓郎 (40814554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 富岡伸元 (80399899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. GENMA Akihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. INOUE Kenich

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. YOSHIZAWA Hirohisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 各務博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 高田弘一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 小林国彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 田原秀晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 井上彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kinoshita Ichiro 木下 一郎

KINOSHITA Ichiro 木下 一郎

Research Projects

Research Products

Co-Researchers

Frequency of driver gene rearrangements forming functional fusion genes and therapeutic targetability in solid tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Optimization of treatment strategy with EZH2 inhibitor for solid cancer with SWI/SNF alterationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of potential therapy using histone modifying enzyme inhibitor to overcome drug resistance of non-small lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Combined inhibition of stem cell markers and histone modification enzymes in non-small cell lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Targeted therapy for cancer stem-like cells of non-small cell lung cancers with inhibition of the cJun transcription factorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of novel molecular targets for lung cancer based on different sensitivity to AP-1 blockadePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Kinoshita Ichiro 木下一郎

KINOSHITA Ichiro 木下一郎