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Kinoshita Ichiro  木下 一郎

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KINOSHITA Ichiro  木下 一郎

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Researcher Number 40343008
Other IDs
External Links
Affiliation (Current) 2025: 北海道大学, 大学病院, 教授
Affiliation (based on the past Project Information) *help 2019 – 2025: 北海道大学, 大学病院, 教授
2017 – 2018: 北海道大学, 医学研究院, 准教授
2016: 北海道大学, 医学研究科, 准教授
2012 – 2015: 北海道大学, 医学(系)研究科(研究院), 准教授
2014: 北海道大学, 大学院医学研究科, 准教授 … More
2012: 北海道大学, 大学院・医学研究科, 准教授
2011: 北海道大学, 医学(系)研究科(研究院), 講師
2007 – 2010: 北海道大学, 大学院・医学研究科, 講師
2006: Hokkaido University, Graduate SChool of Medicine, Lecturer, 大学院医学研究科, 講師
2004 – 2005: 北海道大学, 大学院・医学研究科, 講師 Less
Review Section/Research Field
Principal Investigator
Respiratory organ internal medicine / Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor diagnosis
Keywords
Principal Investigator
肺癌 / EZH2 / HDAC / c-jun / AP-1 / EGFR / ヒストン修飾酵素 / ヒストン修飾 / 分子標的薬 / エピジェネティクス … More / 幹細胞 / 癌幹細胞 / cJun / 転写因子 / CDK4/6 / KDM5 / Everolimus / 固形がん / everolimus / MTOR / CDK4/6 inhibitor / HDAC inhibitor / SMARCA4 / SWI/SNF / 抗癌薬耐性 / エピゲノム / 薬剤耐性 / PBIT / JARID1 / 脱メチル化酵素 / transformation / transcription factor / molecular biology / gene therapy / lung cancer / トランスフォーメーション / 分子生物学 / 遺伝子治療 / 非小細胞肺癌 / side population / SAHA / DZNep / cJun / mcm4 / 癌遺伝子 / インテグリンα6 / 癌 / 遺伝子 / マイクロアレイ / MCM4 / 分子標的 … More
Except Principal Investigator
肺癌 / 非小細胞肺癌 / 免疫チェックポイント阻害薬 / AKR1B10 / α1,6-フコース転移酵素 / 糖転移酵素 / irAE / CD73 / トリプルネガティブ / 効果予測 / がん免疫療法 / Tumor mutational burden / SWI/SNF複合体遺伝子 / 治療効果予測バイオマーカー / 免疫チェックポイント阻害薬(ICI) / SWI/SNF変異 / 治療標的 / Prox1 / 小細胞肺癌 / Numbの機能 / Numb / 組織系 / 肺扁平上皮癌 / 肺腺癌 / EGFR mutation / biomarker / lung cancer / タバコ発癌 / 扁平上皮癌 / 喫煙 / EGF受容体遺伝子変異 / 分子マーカー / フェルスター共鳴エネルギー移動 / バイオイメージング / FRETバイオセンサー / 薬剤耐性 / EGFR-TKI / 国際情報交換 / Lung cancer / Bcl2 family / Bim / Notch / Notch / 併用治療効果 / alfa1,6-フコース転移酵素 / alfa 1-6フコース転移酵素 / 糖転移酵素〓1-6fucosyltransferase / 糖鎖 / バイオマーカー Less
  • Research Projects

    (16 results)
  • Research Products

    (73 results)
  • Co-Researchers

    (22 People)
  •  固形がんのドライバー遺伝子再構成が機能融合遺伝子を形成する頻度と治療標的性の解明Principal Investigator

    • Principal Investigator
      木下 一郎
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Hokkaido University
  •  免疫関連因子CD73のトリプルネガティブ乳癌周術期治療効果・有害事象との関連性の検討

    • Principal Investigator
      高橋 將人
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Hokkaido University
  •  A Study on Predicting the Effectiveness of Cancer Immunotherapy

    • Principal Investigator
      菊地 順子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Hokkaido University
  •  小細胞肺癌におけるProx1によるNotch pathwayの制御機構、治療開発

    • Principal Investigator
      榊原 純 (小西純)
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Hokkaido University
  •  Optimization of treatment strategy with EZH2 inhibitor for solid cancer with SWI/SNF alterationPrincipal Investigator

    • Principal Investigator
      Kinoshita Ichiro
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Hokkaido University
  •  Numb has distinct roles in lung adenocarcinoma and squamous cell carcinomaus us

    • Principal Investigator
      sakakibara jun
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Hokkaido University
  •  Development of potential therapy using histone modifying enzyme inhibitor to overcome drug resistance of non-small lung cancerPrincipal Investigator

    • Principal Investigator
      Kinoshita Ichiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Hokkaido University
  •  Combined inhibition of stem cell markers and histone modification enzymes in non-small cell lung cancerPrincipal Investigator

    • Principal Investigator
      Kinoshita Ichiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Hokkaido University
  •  Study on EGFR-TKI resistance using FRET biosensor

    • Principal Investigator
      Akita Hirotoshi
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Hokkaido University
  •  Combined antitumor effec ot g-secretase inbitiro and ABT-737

    • Principal Investigator
      SAKAKIBARA Jun
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Hokkaido University
  •  Targeted therapy for cancer stem-like cells of non-small cell lung cancers with inhibition of the cJun transcription factorPrincipal Investigator

    • Principal Investigator
      KINOSHITA Ichiro
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Hokkaido University
  •  Alteration of fucosylation and biomarker development in lung cancer

    • Principal Investigator
      AKITA Hirotoshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor diagnosis
    • Research Institution
      Hokkaido University
  •  Identification of novel molecular targets for lung cancer based on different sensitivity to AP-1 blockadePrincipal Investigator

    • Principal Investigator
      KINOSHITA Ichiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Hokkaido University
  •  肺癌および随伴肺疾患における糖転移酵素の発現異常に関する研究

    • Principal Investigator
      AKITA Hirotoshi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Hokkaido University
  •  Research on Molecular Therapeutic Targets and Biomarkers for the Diagnosis and Stratification in Lung Cancer

    • Principal Investigator
      AKITA Hirotoshi
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Hokkaido University
  •  Growth inhibition of non-small cell lung cancer cells by AP-1 blockade using a cJun dominant negative mutant, TAM67Principal Investigator

    • Principal Investigator
      KINOSHITA Ichiro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      HOKKAIDO UNIVERSITY

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All Journal Article Presentation

  • [Journal Article] EGFR inhibition in EGFR-mutant lung cancer cells perturbs innate immune signaling pathways in the tumor microenvironment.2023

    • Author(s)
      Shiiya A, Noguchi T, Tomaru U, Ariga S, Takashima Y, Ohhara Y, Taguchi J, Takeuchi S, Shimizu Y, Kinoshita I, Koizumi T, Matsuno Y, Shinagawa N, Sakakibara-Konishi J, Dosaka-Akita H
    • Journal Title

      Cancer Sci

      Volume: 114 Issue: 4 Pages: 1270-1283

    • DOI

      10.1111/cas.15701

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07691, KAKENHI-PROJECT-23K24099
  • [Journal Article] Effect of comprehensive cancer genomic profiling on therapeutic strategies and clinical outcomes in patients with advanced biliary tract cancer: A prospective multicenter study2022

    • Author(s)
      Takada Kohichi、Kubo Tomohiro、Kikuchi Junko
    • Journal Title

      Frontiers in Oncology

      Volume: 12 Pages: 99-99

    • DOI

      10.3389/fonc.2022.988527

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08080, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-20H03655, KAKENHI-PROJECT-20K07691
  • [Journal Article] Clinical significance of comprehensive genomic profiling tests covered by public insurance in patients with advanced solid cancers in Hokkaido, Japan2021

    • Author(s)
      Kikuchi Junko、Ohhara Yoshihito、Takada Kohichi、Kinoshita Ichiro
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: - Issue: 5 Pages: 753-761

    • DOI

      10.1093/jjco/hyaa277

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08397, KAKENHI-PROJECT-20K07691, KAKENHI-PROJECT-19K09818
  • [Journal Article] Impact of clinical targeted sequencing on endocrine responsiveness in estrogen receptor-positive, HER2-negative metastatic breast cancer2021

    • Author(s)
      Hagio K, Amano T, Hayashi H, Takeshita T, Oshino T, Kikuchi J, Ohhara Y, Yabe I, Kinoshita I, Nishihara H, Yamashita H
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 8109-8109

    • DOI

      10.1038/s41598-021-87645-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07691
  • [Journal Article] Pharmacokinetics, safety, and efficacy of trastuzumab deruxtecan with concomitant ritonavir or itraconazole in patients with HER2-expressing advanced solid tumors2021

    • Author(s)
      Takahashi S, Karayama M, Takahashi M, Watanabe J, Minami H, Yamamoto N, Kinoshita I, Lin CC, Im YH, Achiwa I, Kamiyama E, Okuda Y, Lee C, Bang YJ
    • Journal Title

      Clin Cancer Res

      Volume: 27 Issue: 21 Pages: 5771-5780

    • DOI

      10.1158/1078-0432.ccr-21-1560

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07691
  • [Journal Article] Expression of the immunoproteasome subunit β5i in non-small cell lung carcinomas2020

    • Author(s)
      Kiuchi Takayuki、Tomaru Utano、Ishizu Akihiro、Imagawa Makoto、Iwasaki Sari、Suzuki Akira、Otsuka Noriyuki、Ohhara Yoshihito、Kinoshita Ichiro、Matsuno Yoshihiro、Dosaka-Akita Hirotoshi、Kasahara Masanori
    • Journal Title

      Journal of Clinical Pathology

      Volume: 74 Issue: 5 Pages: 300-306

    • DOI

      10.1136/jclinpath-2020-206618

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07691, KAKENHI-PROJECT-20K21512, KAKENHI-PROJECT-18H02629
  • [Journal Article] Evaluating the immunoproteasome as a potential therapeutic target in cisplatin-resistant small cell and non-small cell lung cancer2020

    • Author(s)
      Shoji T, Kikuchi E, Kikuchi J, Takashima Y, Furuta M, Takahashi H, Tsuji K, Maeda M, Kinoshita I, Dosaka-Akita H, Sakakibara-Konishi J, Konno S
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: in print Issue: 5 Pages: 843-853

    • DOI

      10.1007/s00280-020-04061-9

    • NAID

      120007032615

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-18K08130, KAKENHI-PROJECT-19K23876, KAKENHI-PROJECT-19K23903
  • [Journal Article] Bromodomain and extraterminal domain inhibition synergizes with WEE1‐inhibitor AZD1775 effect by impairing nonhomologous end joining and enhancing DNA damage in nonsmall cell lung cancer2020

    • Author(s)
      Takashima Yuta、Kikuchi Eiki、Kikuchi Junko、Suzuki Motofumi、Kikuchi Hajime、Maeda Makie、Shoji Tetsuaki、Furuta Megumi、Kinoshita Ichiro、Dosaka‐Akita Hirotoshi、Sakakibara‐Konishi Jun、Konno Satoshi
    • Journal Title

      International Journal of Cancer

      Volume: 146 Issue: 4 Pages: 1114-1124

    • DOI

      10.1002/ijc.32515

    • NAID

      120006958367

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-18K08130, KAKENHI-PROJECT-19K23876
  • [Journal Article] Clinical impact of a cancer genomic profiling test using an in‐house comprehensive targeted sequencing system2020

    • Author(s)
      Hayashi Hideyuki、Tanishima Shigeki、Fujii Kyoko、Mori Ryo、Okada Chihiro、Yanagita Emmy、Shibata Yuka、Matsuoka Ryosuke、Amano Toraji、Yamada Takahiro、Yabe Ichiro、Kinoshita Ichiro、Komatsu Yoshito、Dosaka‐Akita Hirotoshi、Nishihara Hiroshi
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 10 Pages: 3926-3937

    • DOI

      10.1111/cas.14608

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07691, KAKENHI-PROJECT-17K15910
  • [Journal Article] DLL3 regulates the migration and invasion of small cell lung cancer by modulating Snail2019

    • Author(s)
      Furuta Megumi、Kikuchi Hajime、Shoji Tetsuaki、Takashima Yuta、Kikuchi Eiki、Kikuchi Junko、Kinoshita Ichiro、Dosaka‐Akita Hirotoshi、Sakakibara‐Konishi Jun
    • Journal Title

      Cancer Science

      Volume: in print Issue: 5 Pages: 1599-1608

    • DOI

      10.1111/cas.13997

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-18K08130
  • [Journal Article] A phase II study of carboplatin, pemetrexed, and bevacizumab followed by erlotinib and bevacizumab maintenance for non-squamous non-small cell lung cancer with wild-type EGFR (HOT1101)2018

    • Author(s)
      Takashina T, Asahina H, Oizumi S, Yamada N, Harada M, Takamura K, Yokouchi H, Harada T, Honjo O, Ogi T, Morikawa N, Kinoshita I, Honda R, Nakano K, Kanazawa K, Amano T, Dosaka-Akita H, Isobe H, Nishimura M
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 23 Issue: 6 Pages: 1060-1069

    • DOI

      10.1007/s10147-018-1318-z

    • NAID

      120006651802

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09639
  • [Journal Article] Updated survival outcomes of NEJ005/TCOG0902: a randomised phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations.2018

    • Author(s)
      Oizumi S, Sugawara S, Minato K, Harada T, Inoue A, Fujita Y, Maemondo M, Watanabe S, Ito K, Gemma A, Demura Y, Fukumoto S, Isobe H, Kinoshita I, Morita S, Kobayashi K, Hagiwara K, Aiba K, Nukiwa T.
    • Journal Title

      ESMO Open

      Volume: 3(2) Issue: 2 Pages: e000313-e000313

    • DOI

      10.1136/esmoopen-2017-000313

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09562, KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-15K09164, KAKENHI-PROJECT-15K09168, KAKENHI-PROJECT-15K09237
  • [Journal Article] Numb has distinct function in lung adenocarcinoma and squamous cell carcinoma2018

    • Author(s)
      Kikuchi Hajime、Sakakibara-Konishi Jun、Furuta Megumi、Kikuchi Eiki、Kikuchi Junko、Oizumi Satoshi、Hida Yasuhiro、Kaga Kichizo、Kinoshita Ichiro、Dosaka-Akita Hirotoshi、Nishimura Masaharu
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 50 Pages: 29379-29391

    • DOI

      10.18632/oncotarget.25585

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-18K08130
  • [Journal Article] Clinicopathologic Features and Immune Microenvironment of Non?Small-cell Lung Cancer With Primary Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors2018

    • Author(s)
      Takashima Yuta、Sakakibara-Konishi Jun、Hatanaka Yutaka、Hatanaka Kanako C.、Ohhara Yoshihito、Oizumi Satoshi、Hida Yasuhiro、Kaga Kichizo、Kinoshita Ichiro、Dosaka-Akita Hirotoshi、Matsuno Yoshihiro、Nishimura Masaharu
    • Journal Title

      Clinical Lung Cancer

      Volume: 19 Issue: 4 Pages: 352-359

    • DOI

      10.1016/j.cllc.2018.02.004

    • NAID

      120006649179

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09639
  • [Journal Article] Combined antitumor effect of γ-secretase inhibitor and ABT-737 in Notch-expressing non-small cell lung cancer2017

    • Author(s)
      Sakakibara-Konishi J, Ikezawa Y, Oizumi S, Kikuchi J, Kikuchi E, Mizugaki H, Kinoshita I, Dosaka-Akita H, Nishimura M
    • Journal Title

      Int J Clin Oncol

      Volume: 22 Issue: 2 Pages: 481-487

    • DOI

      10.1007/s10147-016-1060-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461175
  • [Journal Article] A randomized phase II trial of erlotinib vs. S-1 as a third- or fourth-line therapy for patients with wild-type EGFR non-small cell lung cancer (HOT1002)2017

    • Author(s)
      Ikezawa Y, Asahina H, Oizumi S, Watanabe M, Takamura K, Kawai Y, Yamada N, Harada T, Kinoshita I, Fujita Y, Miyauchi E, Ogi T, Amano T, Furuta M, Sakakibara-Konishi J, Nishihara H, Dosaka-Akita H, Isobe H, Nishimura M; Hokkaido Lung Cancer Clinical Study Group
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 80 Issue: 5 Pages: 955-963

    • DOI

      10.1007/s00280-017-3432-4

    • NAID

      120006533131

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-15K09164
  • [Journal Article] A phase II study of bevacizumab with carboplatin-pemetrexed in non-squamous non-small cell lung carcinoma patients with malignant pleural effusions: North East Japan Study Group Trial NEJ013A.2016

    • Author(s)
      Usui K, Sugawara S, Nishitsuji M, Fujita Y, Inoue A, Mouri A, Watanabe H, Sakai H, Kinoshita I, Ohhara Y, Maemondo M, Kagamu H, Hagiwara K, Kobayashi K
    • Journal Title

      Lung Cancer

      Volume: 99 Pages: 131-136

    • DOI

      10.1016/j.lungcan.2016.07.003

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293196, KAKENHI-PROJECT-26461175
  • [Journal Article] Combined inhibition of EZH2 and HDACs as a potential epigenetic therapy for non-small cell lung cancer cells2016

    • Author(s)
      Takashina T, Kinoshita I, Kikuchi J, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Nishimura M, and Dosaka-Akita H
    • Journal Title

      Cancer Sci

      Volume: (in press)

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26461175
  • [Journal Article] Novel signaling collaboration between TGF-beta and adaptor protein Crk facilitates EMT in human lung cancer2016

    • Author(s)
      Elmansuri AZ, Tanino MA, Mahabir R, Wang L, Kimura T, Nishihara H, Kinoshita I, Dosaka-Akita H, Tsuda M and Tanaka S
    • Journal Title

      Oncotarget

      Volume: (in press) Issue: 19 Pages: 27094-107

    • DOI

      10.18632/oncotarget.8314

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-15K15106, KAKENHI-PROJECT-25460471, KAKENHI-PROJECT-26670414, KAKENHI-PROJECT-15K08359, KAKENHI-PROJECT-16K08703
  • [Journal Article] The coordinated actions of TIM-3 on cancer and myeloid cells in the regulation of tumorigenicity and clinical prognosis in clear cell renal cell carcinomas2015

    • Author(s)
      Komohara Y, Morita T, Annan DA, Horlad H, Ohnishi K, Yamada S, Nakayama T, Kitada S, Suzu S, Kinoshita I, Dosaka-Akita H, Akashi K, Takeya M, Jinushi M
    • Journal Title

      Cancer Immunol Res

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461175
  • [Journal Article] Randomized phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations: NEJ005/TCOG0902.2015

    • Author(s)
      Sugawara S, Oizumi S, Minato K, Harada T, Inoue A, Fujita Y, Maemondo M, Yoshizawa H, Ito K, Gemma A, Nishitsuji M, Harada M, Isobe H, Kinoshita I, Morita S, Kobayashi K, Hagiwara K, Kurihara M, Nukiwa T; North East Japan Study Group and Tokyo Cooperative Oncology Group
    • Journal Title

      Ann Oncol.

      Volume: 26(5) Issue: 5 Pages: 888-94

    • DOI

      10.1093/annonc/mdv063

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-15K09164
  • [Journal Article] Factors associated with a poor response to gefitinib in the NEJ002 study: Smoking and the L858R mutation.2015

    • Author(s)
      Fukuhara T, Yoshizawa H et al.
    • Journal Title

      Lung Cancer

      Volume: 88 Issue: 2 Pages: 181-6

    • DOI

      10.1016/j.lungcan.2015.02.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591156, KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-15K09164, KAKENHI-PROJECT-15K09237, KAKENHI-PROJECT-15K15320
  • [Journal Article] Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers2015

    • Author(s)
      Honma R, Kinoshita I, Miyoshi E, Tomaru U, Matsuno Y, Shimizu Y, Takeuchi S, Kobayashi Y, Kaga K, Taniguchi N, Dosaka-Akita H
    • Journal Title

      Oncology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461175
  • [Journal Article] CD133 expression: a potential prognostic marker for non-small cell lung cancers2014

    • Author(s)
      Mizugaki H, Sakakibara-Konishi J, Kikuchi J, Moriya J, Hatanaka KC, Kikuchi E, Kinoshita I, Oizumi S, Dosaka-Akita H, Matsuno Y and Nishimura M
    • Journal Title

      Int J Clin Oncol

      Volume: 19 Issue: 2 Pages: 254-259

    • DOI

      10.1007/s10147-013-0541-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Journal Article] Cancer stem-like cells derived from chemoresistant tumors have a unique capacity to prime tumorigenic myeloid cells.2014

    • Author(s)
      Yamashina T, Baghdadi M, Yoneda A, Kinoshita I, Suzu S, Dosaka-Akita H, Jinushi M.
    • Journal Title

      Cancer Research

      Volume: 74 Issue: 10 Pages: 2698-2709

    • DOI

      10.1158/0008-5472.can-13-2169

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23591132, KAKENHI-PUBLICLY-25112701, KAKENHI-PUBLICLY-25130701, KAKENHI-PROJECT-26290050, KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-26670183
  • [Journal Article] Updated Overall Survival Results from A Randomized Phase III Trial Comparing Gefitinib with Carboplatin-Paclitaxel for Chemo-Naive Non-Small Cell Lung Cancer with Sensitive EGFR Gene Mutations (NEJ002)2013

    • Author(s)
      Inoue A, Kobayashi K, Maemondo M, et al
    • Journal Title

      Ann Oncol

      Volume: 24 Issue: 1 Pages: 54-9

    • DOI

      10.1093/annonc/mds214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790746, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-24240042, KAKENHI-PROJECT-24591156, KAKENHI-PROJECT-24591184, KAKENHI-PROJECT-24659396
  • [Journal Article] TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance.2013

    • Author(s)
      Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M
    • Journal Title

      Immunity

      Volume: 39 Issue: 6 Pages: 1070-1081

    • DOI

      10.1016/j.immuni.2013.09.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-24790479, KAKENHI-PUBLICLY-25112701, KAKENHI-PUBLICLY-25130701, KAKENHI-PROJECT-25293089, KAKENHI-PROJECT-25461503
  • [Journal Article] Expression of Bim, Noxa, and Puma in non-small cell lung cancer.2012

    • Author(s)
      Sakakibara-Konishi J, Oizumi S, Kikuchi J, Kikuchi E, Mizugaki H, Kinoshita I, Dosaka-Akita H, Nishimura M
    • Journal Title

      BMC Cancer.

      Volume: 12 Issue: 1 Pages: 286-286

    • DOI

      10.1186/1471-2407-12-286

    • NAID

      120004756336

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591146
  • [Journal Article] Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells2012

    • Author(s)
      Kikuchi J, Takashina T, Kinoshita I, Kikuchi E, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Marquez VE, Nishimura M, Dosaka-Akita H
    • Journal Title

      Lung Cancer

      Volume: 78 Issue: 2 Pages: 138-143

    • DOI

      10.1016/j.lungcan.2012.08.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Journal Article] ATM-mediated DNA damage signals mediate immune escape through integrin αvβ3-dependent mechanisms.2012

    • Author(s)
      Jinushi M
    • Journal Title

      Cancer Res

      Volume: 72 Issue: 1 Pages: 56-65

    • DOI

      10.1158/0008-5472.can-11-2028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390113, KAKENHI-PROJECT-21689031, KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132
  • [Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. S.2012

    • Author(s)
      Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J. V. Gorman, J. D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi.
    • Journal Title

      Nat. Immunol.

      Volume: 13 Issue: 9 Pages: 832-842

    • DOI

      10.1038/ni.2376

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J04616, KAKENHI-PROJECT-21390113, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390090, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-23659196, KAKENHI-PUBLICLY-23114501
  • [Journal Article] Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer2011

    • Author(s)
      Kikuchi J, Kinoshita I, Shimizu Y, Kikuchi E, Takeda K, Aburatani H, Oizumi S, Konishi J, Kaga K, Matsuno Y, Birrer MJ, Nishimura M and Dosaka-Akita H
    • Journal Title

      Lung Cancer

      Volume: 72 Issue: 2 Pages: 229-237

    • DOI

      10.1016/j.lungcan.2010.08.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Journal Article] Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis2011

    • Author(s)
      Takeda K, Kinoshita I, Shimizu Y, Matsuno Y, Shichinohe T and Dosaka-Akita H
    • Journal Title

      Anticancer Res

      Volume: 31 Pages: 263-270

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Journal Article] Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.2011

    • Author(s)
      Kikuchi J, Kinoshita I, Birrer MJ, Dosaka-Akita H
    • Journal Title

      Lung Cancer. 72

      Pages: 229-37

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590909
  • [Journal Article] Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells2011

    • Author(s)
      Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H, Yagita H, Takaoka A, Tahara H.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108巻 Issue: 30 Pages: 12425-30

    • DOI

      10.1073/pnas.1106645108

    • NAID

      10030575946

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249069, KAKENHI-PROJECT-21689031, KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132
  • [Journal Article] Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.2010

    • Author(s)
      Kikuchi J, Kinoshita I, et.al.
    • Journal Title

      Lung Cancer

      Volume: 172(9月(Epub))

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590909
  • [Journal Article] Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance.2010

    • Author(s)
      Kikuchi J, Kinoshita I, Dosaka-Akita H
    • Journal Title

      Cancer 116

      Pages: 3015-24

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590909
  • [Journal Article] Distinctive expression of the polycomb group proteins Bmil polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance.2010

    • Author(s)
      Kikuchi J, Kinoshita I, et.al.
    • Journal Title

      Cancer

      Volume: 116 Pages: 3015-3024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590909
  • [Journal Article] Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells.2008

    • Author(s)
      Kikuchi J, Kinoshita I, Birrer MJ, Dosaka-Akita H
    • Journal Title

      Br J Cancer 99(12)

      Pages: 2013-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590909
  • [Journal Article] 肺癌の遺伝子異常2004

    • Author(s)
      木下一郎, 他
    • Journal Title

      呼吸と循環 52・10

      Pages: 1059-1064

    • Data Source
      KAKENHI-PROJECT-16590729
  • [Presentation] The Predictive Potential of Comprehensive SWI/SNF Gene Analysis in Immunotherapy for Malignant Melanoma2024

    • Author(s)
      杢 里花, 野口 卓郎 , 菊地 順子 , 有賀 伸, 木下 一郎
    • Organizer
      日本臨床腫瘍学会総会
    • Data Source
      KAKENHI-PROJECT-22K07292
  • [Presentation] TRK融合陽性の消化器がん患者におけるラロトレクチニブの長期有効性と安全性2022

    • Author(s)
      木下 一郎, Garralda Elena, Hong David S., Xu Ruihua, Deeken John, Italiano Antonine, Liu Tianshu, Calvo Ferrandiz Aitana, Patel Jyoti D., Lee Dae Ho, Norenberg Ricarda, Burcoveanu Domnita-Ileana, Mussi Chiara E., Drilon Alexander, Shen Li
    • Organizer
      第60会日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07691
  • [Presentation] TRK融合陽性の消化器がん患者におけるラロトレクチニブの有効性と安全性2021

    • Author(s)
      木下 一郎, Boni Valentina, Drilon Alexander, Deeken John F., Cabanas Elena G., Chung Hyun C., Oh Do-Youn, Patel Jyoti D., Xu Ruihua, Norenberg Ricarda, Brega Nicoletta, Dima Laura, Hong David S., Berlin Jordan
    • Organizer
      第59回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07691
  • [Presentation] Clinical sequencing with insurance-covered genomic profiling tests in patients with advanced solid cancers in Hokkaido2021

    • Author(s)
      Junko Kikuchi, ‥, Ichiro Kinoshita
    • Organizer
      18th Annual Meeting of Japanese Society of Medical Oncology
    • Data Source
      KAKENHI-PROJECT-20K07691
  • [Presentation] CGP 検査前後の患者に対する意思決定支援(がんゲノム医療中核拠点病院)2021

    • Author(s)
      木下一郎
    • Organizer
      第6 回日本がんサポーティブケア学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07691
  • [Presentation] JARID1 family inhibitor reduces generation of drug resistant EGFR-mutation positive lung cancer cells2019

    • Author(s)
      Ariga S, Kinoshita I, Kikuchi J, Shimizu S, Dosaka-Akita H
    • Organizer
      110th Annual Meeting of the American Association for Cancer Research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09639
  • [Presentation] ヒストン脱メチル化酵素JARID1阻害薬による非小細胞肺癌細胞のEGFR-TKI耐性化の抑制2019

    • Author(s)
      有賀 伸, 木下 一郎, 菊地 順子, 清水 康, 秋田 弘俊,
    • Organizer
      第60回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K09639
  • [Presentation] A phase II study of trastuzumab monotherapy in pretreated patients with non-small cell lung cancers (NSCLCs) harboring HER2 alterations: HOT1303-B trial2018

    • Author(s)
      Kinoshita I, Goda T, Watanabe K, Maemondo M, Oizumi S, Amano T, Hatanaka Y, Matsuno Y, Nishihara H, Asahina H, Harada T, Goto K, Isobe H, Nishimura M, Dosaka-Akita H
    • Organizer
      European Society for Medical Oncology 2018 Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09639
  • [Presentation] DLL3 regulates migration and invasion of Small Cell Lung Cancer2018

    • Author(s)
      Megumi Furuta1, Jun Sakakibara-Konishi1, Tetsuaki Shoji1, Yuta Takashima1, Hajime Kikuchi 1, Eiki Kikuchi1, Junko Kikuchi1, Ichiro Kinoshita2, Hirotoshi Dosaka-Akita2, Masaharu Nishimura1
    • Organizer
      AACR
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08130
  • [Presentation] JARID1ファミリー阻害薬はEGFR変異陽性肺癌細胞株の薬剤耐性化を緩和する2018

    • Author(s)
      有賀 伸, 木下 一郎, 菊地 順子, 清水 康, 秋田 弘俊
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K09639
  • [Presentation] JARIDファミリー阻害薬の非小細胞肺癌細胞株に対する効果2017

    • Author(s)
      有賀伸、木下一郎、菊地順子、清水康、秋田弘俊
    • Organizer
      第58回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K09639
  • [Presentation] 非小細胞肺癌におけるヒストン修飾酵素阻害療法に関する研究2017

    • Author(s)
      木下一郎、秋田弘俊
    • Organizer
      第二回北大・部局横断シンポジウム
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26461175
  • [Presentation] EZH2阻害薬とヒストン脱アセチル化酵素(HDAC)阻害薬の併用療法の非小細胞肺癌(NSCLC)細胞に対する抗腫瘍効果2014

    • Author(s)
      木下一郎,高階太一、菊地順子、榊原純、大泉聡史、西村正治、秋田弘俊
    • Organizer
      第18回日本がん分子標的治療学会学術集会
    • Place of Presentation
      TKPガーデンシティ仙台(宮城県・仙台市)
    • Year and Date
      2014-06-26
    • Data Source
      KAKENHI-PROJECT-26461175
  • [Presentation] Prognostic significance of 〓1,6 fucosyltransferase (〓1,6 FT) in non-small cell lung cancers (NSCLCs).2013

    • Author(s)
      Honma R, Dosaka-Akita H, Kinoshita I
    • Organizer
      2013 Annual Meeting of American Society of Clinical Oncology (ASCO).
    • Place of Presentation
      McCormick Place (シカゴ、米国).
    • Year and Date
      2013-06-01
    • Data Source
      KAKENHI-PROJECT-22501029
  • [Presentation] Role of polycomb group protein EZH2 in lung cancer2012

    • Author(s)
      Kinoshita I
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      教育文化会館, 札幌市
    • Year and Date
      2012-09-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Presentation] Pharmacologic disruption of polycomb group protein EZH2 via 3-Deazaneplanocin A inhibits growth of non-small cell lung cancer cells2012

    • Author(s)
      Kinoshita I
    • Organizer
      5th Asia Pacific Lung Cancer Conference
    • Place of Presentation
      Hilton Fukuoka Sea Hawk, Fukuoka
    • Year and Date
      2012-11-26
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Presentation] Decreased expression of GMD in non-small cell lung cancers (NSCLCs).2011

    • Author(s)
      Honma R, Dosaka-Akita H, Kinoshita I
    • Organizer
      102nd Annual Meeting of AmericanAssociation of Cancer Research (AACR).
    • Place of Presentation
      Orange CountyConvention Center(オーランド、米国)
    • Year and Date
      2011-04-05
    • Data Source
      KAKENHI-PROJECT-22501029
  • [Presentation] Growth inhibition of non-small cell lung cancer cells by the histone methyltransferase ezh2 inhibitor 3-deazaneplanocin2011

    • Author(s)
      Kinoshita I
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場, 名古屋市
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Presentation] Growth inhibition of non-small cell lung cancer cells by the histone methyltransferase ezh2 inhibitor 3-deazaneplanocin2011

    • Author(s)
      Kinoshita I
    • Organizer
      9th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      Hokkaido University, Sapporo
    • Year and Date
      2011-09-30
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Presentation] Growth inhibition of non-small cell lung cancer cells by the histone methyltransferase ezh2 inhibitor 3-deazaneplanocin2011

    • Author(s)
      Kinoshita I, Kikuchi J, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Nishimura M, Dosaka-Akita H
    • Organizer
      9th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      北海道大学(札幌市)
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Presentation] GDP-mannose-4,6-dehydratase (GMD) and GDP-fucose transporter in non-small cell lung cancers (NSCLCs) : their decreased expression insquamous cell carcinomas by immunohistochemistry.2011

    • Author(s)
      Honma R, Dosaka-Akita H, Kinoshita I
    • Organizer
      14th World Conference on Lung Cancer of International Association for the Studyof Lung Cancer.
    • Place of Presentation
      Amsterdam RAI(アムステルダム、オラ ンダ)
    • Year and Date
      2011-07-05
    • Data Source
      KAKENHI-PROJECT-22501029
  • [Presentation] Growth inhibition of non-small cell lung cancer cells by the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin2011

    • Author(s)
      木下一郎,菊地順子,菊地英毅, 清水康, 榊原純, 大泉聡史, 西村正治, 秋田弘俊
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Presentation] Decreased expression of GMDand GDP-fucose transporter is associated with squamous histology in NSCLCs.2011

    • Author(s)
      Honma R, Dosaka-Akita H, Kinoshita I
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場.
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-22501029
  • [Presentation] Distinctive expression of polycomb group proteins Bmil and EZH2 in nonsmall cell lung cancers and their clinical and clinicopathological significance.2010

    • Author(s)
      Kikuchi J, Kinoshita I, et.al.
    • Organizer
      101th Annual Meeting of the American Association for Cancer Research
    • Place of Presentation
      Washington Convention Center (Washington, DC, USA)
    • Year and Date
      2010-04-20
    • Data Source
      KAKENHI-PROJECT-20590909
  • [Presentation] 非小細胞肺癌におけるポリコーム蛋白質Bmi1とEZH2の発現の違いと臨床病理学的意義2010

    • Author(s)
      木下一郎, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-20590909
  • [Presentation] The role of minichromosome maintenance (MCM) protein 4 in proliferation and its clinicopathological significance in non-small cell lung cancers (NSCLCs).2009

    • Author(s)
      Kinoshita I.
    • Organizer
      13th World Conference of Lung Cancer
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2009-08-02
    • Data Source
      KAKENHI-PROJECT-20590909
  • [Presentation] The role of minichromosome maintenance(MCM)protein 4 in proliferation and its clinicopathological significance in non-small cell lung cancers(NSCLCs).2009

    • Author(s)
      Kinoshita I, et.al.
    • Organizer
      13th World Conference of Lung Cancer
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2009-08-03
    • Data Source
      KAKENHI-PROJECT-20590909
  • [Presentation] EZH2阻害薬とヒストン脱アセチル化酵素阻害薬の併用療法の非小細胞肺癌細胞に対する抗腫瘍効果の検討

    • Author(s)
      高階太一、木下一郎、菊地順子、池澤靖元、榊原純、大泉聡史、西村正治、秋田弘俊
    • Organizer
      第54回日本肺癌学会総会
    • Place of Presentation
      ホテルニューオータニ(東京)
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Presentation] Effects of combined epigenetic therapy with EZH2 and HDAC inhibitors on NSCLC cells

    • Author(s)
      Takashina T, Kinoshita I, Kikuchi J, Kikuchi E, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Nishimura M and Dosaka-Akita H
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Presentation] Role of polycomb group protein EZH2 in lung cancer

    • Author(s)
      Kinoshita I
    • Organizer
      第71会日本癌学会学術総会
    • Place of Presentation
      教育文化会館(札幌市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Presentation] Effects of combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin and the histone deacetylase inhibitor SAHA on non-small cell lung cancer cells

    • Author(s)
      Takashina T, Kinoshita I, Kikuchi J, Shimizu Y, Konishi JS, Oizumi S, Nishimura M and Dosaka-Akita H
    • Organizer
      the 105th Annual Meeting of the American Association for Cancer Research
    • Place of Presentation
      San Diego Conventon Center (San Diego)
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Presentation] Pharmacologic disruption of polycomb group protein EZH2 via 3-Deazaneplanocin A inhibits growth of non-small cell lung cancer cells

    • Author(s)
      Kinoshita I
    • Organizer
      5th Asia Pacific Lung Cancer Conference
    • Place of Presentation
      Hilton Fukuoka Sea Hawk (Fukuoka)
    • Data Source
      KAKENHI-PROJECT-23591132
  • [Presentation] ヒストンメチル化酵素EZH2阻害剤3-deazaneplanocin Aによる非小細胞肺癌細胞株に対する増殖抑制効果の検討

    • Author(s)
      高階太一、木下一郎、菊地順子、菊地英毅、清水康、榊原純、大泉聡史、西村正治、秋田弘俊
    • Organizer
      第53回日本肺癌学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Data Source
      KAKENHI-PROJECT-23591132
  • 1.  AKITA Hirotoshi (70222528)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 14 results
  • 2.  SAKAKIBARA Jun (50374278)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 3.  畑中 佳奈子 (10399834)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  畑中 豊 (30589924)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  SHIMIZU Yasushi (10374513)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 6.  JINUSHI Masahisa (40318085)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 7.  Ohba Yusuke (30333503)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  YAMAZAKI Koichi (20312358)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  三善 英知 (20322183)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  菊地 順子 (40739637)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  天野 虎次 (20374514)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  高橋 將人 (50374343)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  野口 卓郎 (40814554)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  富岡 伸元 (80399899)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  GENMA Akihiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  INOUE Kenich
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  YOSHIZAWA Hirohisa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  各務 博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  高田 弘一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 20.  小林 国彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  田原 秀晃
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  井上 彰
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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