HORIBA Mitsuru 堀場充

Researcher Number	40345913
Other IDs
Affiliation (based on the past Project Information) *help	2007 – 2008: Nagoya University, 環境医学研究所, 准教授 2003 – 2006: Nagoya University, Res. Inst. Of Environ. Med., Assistant Professor, 環境医学研究所, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine
Keywords	Principal Investigator ミッドカイン / apoptosis / アポトーシス / ミッドカイン(MK) / remodeling / midkine / 虚血性心筋障害 / リモデリング / -> mice / MK^<- … More / myocardial injury / Midkine / 心筋虚血再灌流傷害 / ミッドカイン (MK) / MKノックアウトマウス / 心筋虚血再灌流障害 / シグナル伝達 / 下肢虚血モデル / 血菅新生 / 閉塞性末梢動脈疾患 / 新生血管 / 下肢虚血 / 血管病態学 … More Except Principal Investigator heart / current / mRNA / calcium / L-type / T-type / mouse / development / signaling cascade / remodeling / Cardiac ion channel / イオンチャネル / アルドステロン / 心肥大 / 培養心筋 / T型Ca^<2+>チャネル / 心臓 / シグナリング / リモデリング / 心筋イオンチャネル / マウス / カルシウムチャネル / イオシチャネル / 心筋細胞 / 発達 Less

Therapeutic agent for occlusive peripheral vascular diseasePrincipal Investigator
- Principal Investigator
  
  HORIBA Mitsuru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
Intracellular signaling for the genesis of cardiac ion channel remodeling in pathological heart
- Principal Investigator
  
  YASUI Kenji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
Midkine plays a protective role against cardiac remodelingPrincipal Investigator
- Principal Investigator
  
  HORIBA Mitsuru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reactionPrincipal Investigator
- Principal Investigator
  
  HORIBA Mitsuru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
Mechanisms of electrophysiological differentiation of cardiac cells during development
- Principal Investigator
  
  YASUI Kenji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University

All 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Patent

[Journal Article] Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction.2009
- Author(s)
  Takenaka H*, Horiba M*, 他7名, Kodama I, Kadomatsu K.
- Journal Title
  
  Am J Physiol Heart Circ Physiol. 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590860
[Journal Article] T-type Ca2+ channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin-NFAT3 activation as well as L-type Ca2+ channel blockers.2008
- Author(s)
  Horiba, Takao, Ueda N, Opthof T, 他6名
- Journal Title
  
  Life Science 82
  
  Pages: 554-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590860
[Journal Article] T-type Ca^<2+> channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin-NFAT3 activation as well as L-type Ca^<2+> channel blockers2008
- Author(s)
  Mitsuru Horiba, Muto Takao, Ueda Norihiro, Opthof Tobias, Keiko Miwa, Mayumi Hojo, Lee Jong-Kook, Kamiya Kaichiro, Kodama Itsuo, Kenji Yasui
- Journal Title
  
  Life Science 82(11-12)
  
  Pages: 554-60
- Data Source
  KAKENHI-PROJECT-19590860
[Journal Article] Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction2008
- Author(s)
  Takenaka H*, Horiba M*, Ishiguro H, Sumida A, Hojo M, Usui A, Akita T, Sakuma S, Ueda Y, Kodama I, Kadomatsu K
- Journal Title
  
  Am J Physiol Heart Circ Physiol 296(2)
  
  Pages: 462-9
- Data Source
  KAKENHI-PROJECT-19590860
[Journal Article] Aldosterone modulates If current through gene expression in cultured neonatal rat ventricular myocytes2007
- Author(s)
  Muto Takao, Ueda Norihiro, Opthof Tobias, Ohkusa Tomoko, Nagata Kozo, Suzuki Shinsuke, Tsuji Yukiomi, Horiba Mitsuru, Lee Jong-Kook, Honjo Haruo, Kamiya Kaichiro, Kodama Itsuo, Yasui Kenji
- Journal Title
  
  Am J Physiol Heart Circ Physiol 293(5)
  
  Pages: 2710-8
- Data Source
  KAKENHI-PROJECT-19590860
[Journal Article] Aldosterone modulates If current through gene expression in cultured neonatal rat ventricular myocytes.2007
- Author(s)
  Muto T, Ueda N, Opthof T, Ohkusa T, Nagata K, Suzuki S, Tsuji Y, Horiba M, Lee J-K, Honjo H, Kamiya K, Kodama I, Yasui K.
- Journal Title
  
  Am J Physiol Heart Circ Physiol 293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590860
[Journal Article] CH-E14 に基づいた心毒性治験のためのQT計測システム2007
- Author(s)
  武藤貴雄, 安井健二, 植田典浩, 堀場充, 神谷香一郎, 児玉逸雄
- Journal Title
  
  Japanese Journal of Electrocardiology Vol.27 No.1
- Data Source
  KAKENHI-PROJECT-19590860
[Journal Article] Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction.2006
- Author(s)
  HORIBA Mitsuru
- Journal Title
  
  Circulation 114
  
  Pages: 1713-1720
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590720
[Journal Article] Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction.2006
- Author(s)
  HORIBA Mitsuru
- Journal Title
  
  Ciculation 114
  
  Pages: 1713-1720
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590721
[Journal Article] Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction2006
- Author(s)
  Mitsuru Horiba
- Journal Title
  
  Circulation 114
  
  Pages: 1713-1720
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590721
[Journal Article] Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction.2006
- Author(s)
  HORIBA Mitsuru
- Journal Title
  
  Ciculation 114
  
  Pages: 1713-1720
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590720
[Journal Article] T-type Ca^<2+> channel blockers prevents cardiac cell hypertrophy through an inhibition of NFAT-3 activation2005
- Author(s)
  Mitsuru Horiba
- Journal Title
  
  Circulation Journal 68(Suppl.I)
  
  Pages: 588-588
- Data Source
  KAKENHI-PROJECT-17590720
[Journal Article] Ca_v3.2 subunit underlies the functional T-type Ca^<2+> channel in murine hearts during the embryonic period.2004
- Author(s)
  NIWA N, YASUI K, OPTHOF T, TAKEMURA H, SHIMIZU A, HORIBA M, (他3), KODAMA I
- Journal Title
  
  American Journal of Physiology : Heart and Circulatory Physiology 286
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590734
[Journal Article] Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period.2004
- Author(s)
  NIWA N, YASUI K, OPTHOF T, TAKEMURA H, SHIMIZU A, HORIBA M, LEE J-K, HONJO H, KAMIYA K, KODAMA I
- Journal Title
  
  Am J Physiol Heart Circ Physiol. 286(6)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590734
[Journal Article] Overexpression of calpastatin by gene transfer prevents troponin I degradation and ameliorates contractile dysfunction in rat hearts subjected to ischemia/reperfusion.2003
- Author(s)
  MAEKAWA A, LEE J-K, NAGAYA T, KAMIYA K, YASUI K, HORIBA M, MIWA K, UZZAMAN M, UEDA Y, KODAMA I
- Journal Title
  
  Journal of Molecular and Cellular Cardiology 35
  
  Pages: 1277-1284
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590734
[Journal Article] Overexpression of calpastatin by gene transfer prevents troponin I degradation and ameliorates contractile dysfunction in rat hearts subjected to ischemia/reperfusion.2003
- Author(s)
  MAEKAWA At, LEE J-K, NAGAYA T, KAMIYA K, YASUI K, HORIBA M, (他3), KODAMA I
- Journal Title
  
  Journal of Molecular and Cellular Cardiology 35
  
  Pages: 1277-1284
- Data Source
  KAKENHI-PROJECT-15590734
[Journal Article] Overexpression of calpastatin by gene transfer prevents troponin I degradation and ameliorates contractile dysfunction in rat hearts subjected to ischem2003
- Author(s)
  MAEKAWA A, LEE J-K, NAGAYA T, KAMIYA K, YASUI K, HORIBA M, (他3), KODAMA I
- Journal Title
  
  Journal of Molecular and Cellular Cardiology 35
  
  Pages: 1277-1284
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590734
[Patent] 一酸化窒素合成酵素活性化剤2008
- Inventor(s)
  堀場, 門松, 児玉, 村松, 石黒, 竹中, 住田
- Industrial Property Rights Holder
  名古屋大学
- Filing Date
  2008-04-08
- Overseas
- Data Source
  KAKENHI-PROJECT-19590860
[Patent] 非虚血性心筋障害に対する医薬2008
- Inventor(s)
  堀場, 門松, 原田, 竹中, 石黒, 住田, 蝶野
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Number
  2008-284918
- Filing Date
  2008-11-06
- Data Source
  KAKENHI-PROJECT-19590860
[Patent] 一酸化窒素合成酵素活性化剤2008
- Inventor(s)
  堀場充, 他6名
- Industrial Property Rights Holder
  名古屋大学
- Filing Date
  2008-04-08
- Overseas
- Data Source
  KAKENHI-PROJECT-19590860
[Patent] 閉塞性末梢血管疾患治療剤、およびその利用2006
- Inventor(s)
  堀場充
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Number
  2006-286848
- Filing Date
  2006-10-20
- Data Source
  KAKENHI-PROJECT-17590721
[Patent] 心筋障害又は心不全の治療もしくは予防組成物2005
- Inventor(s)
  堀場充, 門松健治, 児玉逸雄
- Industrial Property Rights Holder
  名古屋大学
- Filing Date
  2005-12-06
- Data Source
  KAKENHI-PROJECT-17590721
[Patent] ミッドカインによる心筋障害予防および治療への応用2003
- Inventor(s)
  堀場充, 児玉逸雄, 門松健治, 村松喬
- Industrial Property Rights Holder
  堀場充, 児玉逸雄
- Industrial Property Number
  2003-343805
- Filing Date
  2003-08-29
- Acquisition Date
  2003-11-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590734
[Presentation] MK gene transfer causes amelioration of cardiac remodeling after myocardial infarction2009
- Author(s)
  SUMIDA Arihiro, HORIBA Mitsuru, ISHIGURO Hisaaki, TAKENAKA Hiroharu, HARADA Masahide, UEDA Norihiro, LEE Jong-Kook, KAMIYA Kaichiro, KADOMATSU Kenji, KODAMA Itsuo
- Organizer
  The 73^<rd> Annual Scientific Meeting of the Japanese Circulation
- Place of Presentation
  Osaka, Japan
- Year and Date
  2009-03-21
- Data Source
  KAKENHI-PROJECT-19590860
[Presentation] Midkine prevents cardiac remodeling in rabbit congestive heart failure through its anti-apoptotic effect2009
- Author(s)
  HARADA Masahide, TSUJI Yukiomi, SUMIDA Arihiro, HOJO Mayumi, KAMIYA Kaichiro, KODAMA Itsuo, HORIBA Mitsuru
- Organizer
  The 73^<rd> Annual Scientific Meeting of the Japanese Circulation
- Place of Presentation
  Osaka, Japan
- Year and Date
  2009-03-22
- Data Source
  KAKENHI-PROJECT-19590860
[Presentation] Midkine gene transfer ameliorates ischemic cardiomyopathy through enhancements of neovascularization via Akt/PI3 kinase and ERK pathways and anti-apoptosis by regulating Bcl-2 and bax2008
- Author(s)
  SUMIDA Arihiro, HORIBA Mitsuru, ISHIGURO Hisaaki, TAKENAKA Hiroharu, UEDA Norihiro, LEE Jong-Kook, MUROHARA Toyoaki, KADOMATSU Kenji, KODAMA Itsuo
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2008-11-10
- Data Source
  KAKENHI-PROJECT-19590860
[Presentation] Midkine gene transfer ameliorates ischemic cardiomyopathy through enhancements of neovascularization via Akt/PI3 kinase and ERK pathways and anti-apoptosis by regulating Bcl-2 and bax.2008
- Author(s)
  SUMIDA Arihiro, HORIBA Mitsuru
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  New Orleans, LA, US
- Year and Date
  2008-11-10
- Data Source
  KAKENHI-PROJECT-19590860

1. KODAMA Ituo (30124720)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
2. KADOMATU Kenji (80204519)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. YASUI Kenji (70283471)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. LEE Jong-kook (60303608)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MURAMATSU Takashi (00030891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HORIBA Mitsuru 堀場 充

Research Projects

Research Products

Co-Researchers

Therapeutic agent for occlusive peripheral vascular diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Intracellular signaling for the genesis of cardiac ion channel remodeling in pathological heart

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Midkine plays a protective role against cardiac remodelingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of electrophysiological differentiation of cardiac cells during development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction.2009

Author(s)

Journal Title

Data Source

[Journal Article] T-type Ca2+ channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin-NFAT3 activation as well as L-type Ca2+ channel blockers.2008

Author(s)

Journal Title

Data Source

[Journal Article] T-type Ca^<2+> channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin-NFAT3 activation as well as L-type Ca^<2+> channel blockers2008

Author(s)

Journal Title

Data Source

[Journal Article] Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction2008

Author(s)

Journal Title

Data Source

[Journal Article] Aldosterone modulates If current through gene expression in cultured neonatal rat ventricular myocytes2007

Author(s)

Journal Title

Data Source

[Journal Article] Aldosterone modulates If current through gene expression in cultured neonatal rat ventricular myocytes.2007

Author(s)

Journal Title

Data Source

[Journal Article] CH-E14 に基づいた心毒性治験のためのQT計測システム2007

Author(s)

Journal Title

Data Source

[Journal Article] Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction.2006

Author(s)

Journal Title

HORIBA Mitsuru 堀場充