Ohora Masatsugu 大洞將嗣

… Alternative Names

OH-HORA Masatsugu 大洞將嗣

大洞将嗣オオホラマサツグ

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Researcher Number	40351506
Other IDs
Affiliation (Current)	2025: 埼玉医科大学, 医学部, 教授 2025: 順天堂大学, 大学院医学研究科, 非常勤講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 順天堂大学, 大学院医学研究科, 先任准教授 2018 – 2020: 順天堂大学, 医学(系)研究科(研究院), 先任准教授 2013 – 2017: 九州大学, 生体防御医学研究所, 准教授 2009 – 2012: Tokyo Medical and Dental University, 歯と骨のGCOE拠点, GCOE拠点形成特任教員 2011: 東京医科歯科大学, 歯と骨のＧＣＯＥ拠点, ＧＣＯＥ拠点形成特任教員 2010: Tokyo Medical and Dental University, その他 2002 – 2003: 関西医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Immunology / Basic Section 49070:Immunology-related / General pharmacology / Biological Sciences Except Principal Investigator Orthodontics/Pediatric dentistry / Immunology
Keywords	Principal Investigator カルシウム / T細胞 / 制御性T細胞 / イオンチャネル / シグナル情報伝達 / T細胞分化 / サイトカイン / リンパ球分化 / 翻訳 / ミネラル … More / リンパ球 / 初期分化 / βセレクション / betaセレクション / シグナル情報伝達系 / 受容体・チャネル / 免疫シグナル伝達 / ヒストン脱メチル化 / IL-4 / ヘルパーT細胞 / 免疫寛容 / 樹状細胞 / カルシウムシグナル / 腸管上皮細胞間リンパ球 / iNKT細胞 / 自己免疫 … More Except Principal Investigator BCR / 外胚葉異形成症 / カルシウムシグナル / 歯科矯正学 / 唾液腺 / エナメル質 / 歯 / カルシウムイオン / STIM1 / ストア作動性カルシウム流入 / immune response / B lymphocyte development / signal transduction / effector molecules / adaptor molecules / 抗原反応 / ノックアウトマウス / PLC-γ2 / BLNK / c-Rel / 転写因子 / アダプター分化 / B細胞活性 / CD40 / BANK / B細胞活性化 / B細胞分化 / PI3キナーゼ / BCAP / 免疫応答 / Bリンパ球分化 / シグナル伝達 / エフェクター分子 / アダプター分子 Less

Elucidation of molecular mechanisms of lymphopoiesis by essential minerals through TRPM7Principal Investigator
- Principal Investigator
  
  大洞將嗣
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Juntendo University
Elucidation of novel molecular mechanisms of early T cell development by regulation of intracellular ion homeostasisPrincipal Investigator
- Principal Investigator
  
  Masatsugu Oh-hora
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Juntendo University
Molecular basis for the mechanism of ectodermal dysplasia caused by abnormal calcium signaling
- Principal Investigator
  
  Haruyama Naoto
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Kyushu University
Elucidation of molecular mechanisms of the selection and maturation of thymocytesPrincipal Investigator
- Principal Investigator
  
  Oh-hora Masatsugu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Kyushu University
Calcium signal as a potential clinical target for breast cancerPrincipal Investigator
- Principal Investigator
  
  Masatsugu Oh-hora
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
Elucidation of the role of calcium signaling on peripheral immune tolerance.Principal Investigator
- Principal Investigator
  
  OH-HORA Masatsugu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kyushu University
  Tokyo Medical and Dental University
T系列細胞群の分化・機能におけるカルシウム流入制御機構の解明Principal Investigator
- Principal Investigator
  
  大洞將嗣
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
カルシウム流入制御機構を介した自己免疫疾患発症機序の理解と解析Principal Investigator
- Principal Investigator
  
  大洞將嗣
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
Quantitative and qualitative regulation of cellular signaling in immune system
- Principal Investigator
  
  KUROSAKI Tomohiro
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  RIKEN
  Kansai Medical University

[Book] 医学のあゆみ2019
- Author(s)
  大洞将嗣
- Total Pages
  251
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-18K07178
[Book] Calcium entry channels in non-excitable cells2017
- Author(s)
  Oh-hora M, Lu X.
- Total Pages
  19
- Publisher
  CRC press
- Data Source
  KAKENHI-PROJECT-26293108
[Book] Chronic Inflammation (Miyasaka M. and Takatsu K., Editors)2016
- Author(s)
  Oh-hora M.
- Total Pages
  14
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-26293108
[Book] 医学のあゆみ2014
- Author(s)
  大洞将嗣
- Total Pages
  2
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-26670125
[Book] 医学のあゆみ2014
- Author(s)
  大洞将嗣
- Total Pages
  2
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-26293108
[Book] イラストで徹底理解するシグナル伝達キーワード事典2012
- Author(s)
  大洞将嗣、黒崎知博
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23590565
[Book] イラストで徹底理解する　シグナル伝達キーワード事典2012
- Author(s)
  大洞将嗣、黒崎知博
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23590565
[Book] イラストで徹底理解する　シグナル伝達キーワード事典2012
- Author(s)
  大洞将嗣、高柳広
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23590565
[Book] イラストで徹底理解するシグナル伝達キーワード事典2012
- Author(s)
  大洞将嗣、高柳広
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23590565
[Journal Article] Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury2024
- Author(s)
  Jo-Watanabe A, Inaba T, Osada T, Hashimoto R, Nishizawa T, Okuno T, Ihara S, Touhara K, Hattori N, Oh-Hora M, Nureki O, Yokomizo T
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 1530-1530
- DOI
  10.1038/s41467-024-45579-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07255, KAKENHI-PROJECT-21H04798, KAKENHI-PROJECT-23K21384
[Journal Article] Orai2 channel regulates prostaglandin E2 production in TNFα/IL1α‐stimulated astrocytes2022
- Author(s)
  Nakajima Hiroki、Fujita Sayaka、Kakae Masashi、Nagayasu Kazuki、Oh‐hora Masatsugu、Shirakawa Hisashi、Kaneko Shuji
- Journal Title
  
  Glia
  
  Volume: 70 Issue: 9 Pages: 1666-1680
- DOI
  10.1002/glia.24188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07064, KAKENHI-PROJECT-21K19334, KAKENHI-PROJECT-23K21384
[Journal Article] Selective suppression of IL-10 transcription by calcineurin in dendritic cells through inactivation of CREB2021
- Author(s)
  Lu Xiuyuan、Oh-hora Masatsugu、Takeda Kiyoshi、Yamasaki Sho
- Journal Title
  
  International Immunology
  
  Volume: 34 Issue: 4 Pages: 197-206
- DOI
  10.1093/intimm/dxab112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00505, KAKENHI-PROJECT-23K21384
[Journal Article] Stromal Interaction Molecule Deficiency in T Cells Promotes Spontaneous Follicular Helper T Cell Development and Causes Type 2 Immune Disorders2019
- Author(s)
  Oh-hora Masatsugu、Lu Xiuyuan、Shiokawa Moe、Takayanagi Hiroshi、Yamasaki Sho
- Journal Title
  
  The Journal of Immunology
  
  Volume: 0 Issue: 9 Pages: 2616-2627
- DOI
  10.4049/jimmunol.1700610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-18K07178, KAKENHI-PROJECT-17H04087
[Journal Article] Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3?stimulated murine basophils2019
- Author(s)
  Yoshikawa Soichiro、Oh-hora Masatsugu、Hashimoto Ryota、Nagao Toshihisa、Peters Louis、Egawa Mayumi、Ohta Takuya、Miyake Kensuke、Adachi Takahiro、Kawano Yohei、Yamanishi Yoshinori、Karasuyama Hajime
- Journal Title
  
  Science Signaling
  
  Volume: 12 Issue: 576
- DOI
  10.1126/scisignal.aav2060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05786, KAKENHI-PROJECT-18K07178, KAKENHI-PROJECT-19K07501, KAKENHI-PROJECT-19K07620, KAKENHI-PROJECT-19H01025, KAKENHI-PROJECT-18K15180
[Journal Article] Stim1 Regulates Enamel Mineralization and Ameloblast Modulation2017
- Author(s)
  Y. Furukawa, N. Haruyama, M. Nikaido, M. Nakanishi, N. Ryu, M. Oh-Hora, K. Kuremoto, K. Yoshizaki, Y. Takano, I. Takahashi
- Journal Title
  
  Journal of Dental Research
  
  Volume: 96 Issue: 12 Pages: 1422-1429
- DOI
  10.1177/0022034517719872
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11458, KAKENHI-PROJECT-16K11592, KAKENHI-PROJECT-17K11940, KAKENHI-PROJECT-17K19765, KAKENHI-PROJECT-17H04415, KAKENHI-PROJECT-15H05688, KAKENHI-PROJECT-15K11348
[Journal Article] STIM2 regulates AMPA receptor trafficking and plasticity at hippocampal synapses.2017
- Author(s)
  Yap KA, Shetty MS, Garcia-Alvarez G, Lu B., Alagappan D, Oh-hora M, Sajikumar S, Fivaz M.
- Journal Title
  
  Neurobiol Learn Mem
  
  Volume: 138 Pages: 54-61
- DOI
  10.1016/j.nlm.2016.08.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293108
[Journal Article] Impaired spatial memory and enhanced long-term potentiation in mice with forebrain-specific ablation of the Stim genes.2015
- Author(s)
  Garcia-Alvarez G, Shetty MS, Lu B, Yap KA, Oh-hora M, Sajikumar S, Bichler Z, Fivaz M.
- Journal Title
  
  Front Behav Neurosci.
  
  Volume: 9
- DOI
  10.3389/fnbeh.2015.00180
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670125, KAKENHI-PROJECT-26293108
[Journal Article] Crossreactive αβ T cell receptors are the predominant targets of thymocyte negative selection.2015
- Author(s)
  McDonald BD, Bunker JJ, Erickson SA, Oh-hora M, Bendelac A.
- Journal Title
  
  Immunity
  
  Volume: 43 Issue: 5 Pages: 859-869
- DOI
  10.1016/j.immuni.2015.09.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670125, KAKENHI-PROJECT-26293108
[Journal Article] C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation.2015
- Author(s)
  Miyake Y, Masatsugu OH, Yamasaki S.
- Journal Title
  
  J Immunol.
  
  Volume: 194 Issue: 11 Pages: 5366-74
- DOI
  10.4049/jimmunol.1402429
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-25460593, KAKENHI-PROJECT-26670125, KAKENHI-PROJECT-26293099, KAKENHI-PROJECT-26293108
[Journal Article] Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses.2015
- Author(s)
  Kiyotake R, Oh-Hora M, Ishikawa E, Miyamoto T, Ishibashi T, Yamasaki S.
- Journal Title
  
  J Biol Chem.
  
  Volume: 290 Issue: 42 Pages: 25322-32
- DOI
  10.1074/jbc.m115.645234
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-26670125, KAKENHI-PROJECT-26293099, KAKENHI-PROJECT-26293108
[Journal Article] Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.2014
- Author(s)
  Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Oh-hora, M., Kodama, T., Tanaka, S., Bluestone, JA. and Takayanagi, H.
- Journal Title
  
  Nature Medicine
  
  Volume: 20 Issue: 1 Pages: 62-68
- DOI
  10.1038/nm.3432
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590565, KAKENHI-PROJECT-23689075, KAKENHI-ORGANIZER-24111001, KAKENHI-PUBLICLY-24117725, KAKENHI-PROJECT-24390412, KAKENHI-PROJECT-25670188, KAKENHI-PROJECT-25670228, KAKENHI-PROJECT-25670636, KAKENHI-PROJECT-25670773
[Journal Article] Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria.2014
- Author(s)
  Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-Hora M, Akashi K, Yamasaki S.
- Journal Title
  
  Immunity
  
  Volume: 41 Issue: 3 Pages: 402-13
- DOI
  10.1016/j.immuni.2014.08.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130002, KAKENHI-PROJECT-23390101, KAKENHI-PROJECT-25253069, KAKENHI-PROJECT-25293192, KAKENHI-PROJECT-25460593, KAKENHI-PROJECT-25461168, KAKENHI-PROJECT-25461178, KAKENHI-PLANNED-26110006, KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-26293089, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-26293099, KAKENHI-PROJECT-26293108, KAKENHI-PROJECT-26670125, KAKENHI-PROJECT-26670213
[Journal Article] Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry2013
- Author(s)
  Oh-hora, M., et al.
- Journal Title
  
  Immunity
  
  Volume: 38 Issue: 5 Pages: 1-15
- DOI
  10.1016/j.immuni.2013.02.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590565, KAKENHI-PROJECT-23229005
[Journal Article] STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice2012
- Author(s)
  Li, T., et al.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 32 Issue: 15 Pages: 3009-3017
- DOI
  10.1128/mcb.06599-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590565
[Journal Article] STIM1 juxtaposes ER to phagosomes, generating Ca(2+) hotspots that boost phagocytosis2012
- Author(s)
  Nunes, P., et al.
- Journal Title
  
  Curr Biol
  
  Volume: 22 Issue: 21 Pages: 1990-1997
- DOI
  10.1016/j.cub.2012.08.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590565
[Journal Article] STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome2012
- Author(s)
  Cheng, KT., et al
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109 Issue: 36 Pages: 14544-14549
- DOI
  10.1073/pnas.1207354109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590565
[Journal Article] Stanninocalcin 2 is a negative modulator of store-operated calcium entry2011
- Author(s)
  Zeiger, W., Ito, D., Swetlik, C., Oh-hora, M., Villereal, ML. and Thinakaran, G.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 31 Issue: 18 Pages: 3710-3722
- DOI
  10.1128/mcb.05140-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590565, KAKENHI-PROJECT-23591254
[Journal Article]2011
- Author(s)
  Nakashima, T., et al
- Journal Title
  
  Nat Med
  
  Volume: 17 Issue: 10 Pages: 1231-1234
- DOI
  10.1038/nm.2452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00131, KAKENHI-PUBLICLY-22021014, KAKENHI-PROJECT-23590565
[Journal Article] The calcium/NEAT pathway : role in development and function of regulatory T cells.2009
- Author(s)
  Oh-hora M., Rao A.
- Journal Title
  
  Microbes Infecs. 11
  
  Pages: 612-619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890069
[Journal Article] Calcium signaling in the development and function of T-lineage cells.2009
- Author(s)
  Oh-hora M.
- Journal Title
  
  Immunol Rev. 231
  
  Pages: 210-224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890069
[Journal Article] Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation.2004
- Author(s)
  Aiba, Y., Oh-hora, M., Kiyonaka, S., Kimura, Y., Hijikata, A., Mori, Y., Kurosaki, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.U.S.A. 101
  
  Pages: 16612-16617
- Data Source
  KAKENHI-PROJECT-13854013
[Journal Article] Requirement for Ras Guanine Nucleotide Releasing Protein 3 in coupling PLC-ν2 to Ras in B cell receptor signaling.2003
- Author(s)
  Oh-hora, M. et al.
- Journal Title
  
  J.Exp.Med. 198
  
  Pages: 1841-1851
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854013
[Journal Article] Requirement for Ras Guanine Nucleotide Releasing Protein 3 in coupling PLC-γ2 to Ras in B cell receptor signaling.2003
- Author(s)
  Oh-hora, M. et al.
- Journal Title
  
  J.Exp.Med. 198
  
  Pages: 1841-1851
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854013
[Presentation] カルシウム流入を介した免疫調節機構とその異常による疾患2023
- Author(s)
  大洞将嗣
- Organizer
  日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K21384
[Presentation] The leukotriene B4-BLT1 axis in neutrophils exacerbates crescentic glomerulonephritis2022
- Author(s)
  Masatsugu Oh-hora, Ryotaro Shioda, Airi Jo-Watanabe, Toshiaki Okuno, Kazuko Saeki, Maiko Nakayama, Yusuke Suzuki, Takehiko Yokomizo
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21384
[Presentation] 炎症性刺激を受けたアストロサイトにおけるOrai2チャネルの機能解明2022
- Author(s)
  中島弘貴，藤田沙也香，抱将史，永安一樹，大洞将嗣，白川久志，金子周司
- Organizer
  第141回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-23K21384
[Presentation] Orai2チャネルは炎症制刺激を受けたアストロサイトにおけるプロスタグランジンE2産生を制御する2022
- Author(s)
  中島弘貴，藤田沙也香，抱将史，永安一樹，大洞将嗣，白川久志，金子周司
- Organizer
  TRPチャネル研究会2022
- Data Source
  KAKENHI-PROJECT-23K21384
[Presentation] T細胞分化におけるイオンチャネルTRPM7の役割2021
- Author(s)
  大洞将嗣、横溝岳彦
- Organizer
  Kyoto T cell Conference
- Data Source
  KAKENHI-PROJECT-23K21384
[Presentation] A critical role of transient receptor melastatin 7 in early T cell development2021
- Author(s)
  Masatsugu Oh-hora and Takehiko Yokomizo
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21384
[Presentation] Stim-deficiency in T cells promotes spontaneous follicular T cell development and causes type 2 immune disorders2019
- Author(s)
  Oh-hora M, Lu X, Shiokawa M, Takayanagi H, Yamasaki S.
- Organizer
  FASEB Science research conferences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07178
[Presentation] Stim1はマウスのエナメル質の石灰化およびエナメル芽細胞成熟期にみられる周期性を制御する2017
- Author(s)
  古川雄亮, 春山直人, 梅田まりこ, 中西正光, 笠法子, 大洞将嗣, 呉本晃一, 吉崎恵悟, 高橋一郎
- Organizer
  第12回九州矯正歯科学会学術大会
- Place of Presentation
  宮崎
- Year and Date
  2017-03-18
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] Loss of store-operated Ca2+ entry in T cells causes autoimmunity through follicular helper T cell activation2017
- Author(s)
  Masatsugu Oh-hora, Xiuyuan Lu, Moe Shiokawa, Sho Yamasaki
- Organizer
  7th International Workshop of Kyoto T cell Conference
- Place of Presentation
  京都
- Year and Date
  2017-03-13
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] ストア作動性Ca2+流入異常による外胚葉異形成症におけるエナメル質形成不全症の発症メカニズム2016
- Author(s)
  古川雄亮, 春山直人, 梅田まりこ, 中西正光, 笠法子, 大洞将嗣, 呉本晃一, 吉崎恵悟, 高橋一郎
- Organizer
  第75回日本矯正歯科学会大会学術大会
- Place of Presentation
  徳島
- Year and Date
  2016-11-07
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] Loss of calcium entry in T cells causes autoimmunity associated with type 2 immune responses2016
- Author(s)
  Masatsugu Oh-hora, Xiuyuan Lu, Moe Shiokawa, Sho Yamasaki
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] STIM2 plays an essential role in IL-4 production by IL-33-timulated basophils2016
- Author(s)
  Soichiro Yoshikawa, Masatsugu Oh-hora, Yoshinori Yamanishi, Hajime Karasuyama
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  那覇
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] STIM-ORAI-mediated control of immune homeostasis2016
- Author(s)
  Oh-hora M, Lu X, Yamasaki S.
- Organizer
  FASEB Science Research Conference
- Place of Presentation
  Lisbon, Portugal
- Year and Date
  2016-06-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] カルシウム流入欠損による濾胞ヘルパーT細胞機能亢進2016
- Author(s)
  大洞将嗣, 陸修遠, 山﨑晶
- Organizer
  Kyoto T cell Conference
- Place of Presentation
  京都
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] Endoplasmic reticulum calcium sensors, Stim1 and Stim2, control dendritic cell functions.2015
- Author(s)
  Soichiro Yoshikawa, Masatsugu Oh-hora, Kensuke Miyake, Lihua Li, Takuya Ohta, Kayo Horiguchi, Yoshinori Yamanishi, Hajime Karasuyama
- Organizer
  NIPS International Workshop, TRPs and SOCs
- Place of Presentation
  岡崎
- Year and Date
  2015-06-04
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] Endoplasmic reticulum calcium sensors, Stim1 and Stim2, control dendritic cell functions.2015
- Author(s)
  Soichiro Yoshikawa, Masatsugu Oh-hora, Kensuke Miyake, Lihua Li, Takuya Ohta, Kayo Horiguchi, Yoshinori Yamanishi, Hajime Karasuyama
- Organizer
  NIPS International Workshop, TRPs and SOCs
- Place of Presentation
  岡崎
- Year and Date
  2015-06-04
- Data Source
  KAKENHI-PROJECT-26670125
[Presentation] T-cell specific loss of store-operated calcium entry causes Th2-type chronic inflammation.2015
- Author(s)
  Masatsugu Oh-hora, Xiuyuan Lu, Sho Yamasaki
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26670125
[Presentation] Deficiency of Stim-dependent Ca2+ entry in T cells promotes IL-4-producing follicular helper T cell differentiation and causes chronic inflammation.2015
- Author(s)
  大洞将嗣, 陸修遠, 山﨑晶
- Organizer
  Kyoto T cell Conference
- Place of Presentation
  京都
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] Deficiency of Stim-dependent Ca2+ entry in T cells promotes IL-4-producing follicular helper T cell differentiation and causes chronic inflammation.2015
- Author(s)
  大洞将嗣, 陸修遠, 山﨑晶
- Organizer
  Kyoto T cell Conference
- Place of Presentation
  京都
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-26670125
[Presentation] T-cell specific loss of store-operated calcium entry causes Th2-type chronic inflammation.2015
- Author(s)
  Masatsugu Oh-hora, Xiuyuan Lu, Sho Yamasaki
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] Role of STIM-mediated calcium signaling in immune system2015
- Author(s)
  Masatsugu Oh-hora, Xiuyuan Lu, Sho Yamasaki
- Organizer
  The 10th International Symposium of the Institute Network
- Place of Presentation
  札幌
- Year and Date
  2015-07-23
- Invited
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] Role of STIM-mediated calcium signaling in immune system2015
- Author(s)
  Masatsugu Oh-hora, Xiuyuan Lu, Sho Yamasaki
- Organizer
  The 10th International Symposium of the Institute Network
- Place of Presentation
  札幌
- Year and Date
  2015-07-23
- Invited
- Data Source
  KAKENHI-PROJECT-26670125
[Presentation] ストア作動性カルシウム流入の異常による疾患発症メカニズム2014
- Author(s)
  大洞将嗣、小松紀子、Anjana Rao、高柳広
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] NFAT2-dependent IL-4-producing follicular helper T cells is a critical factor in T_H2 inflammation by the lack of store-operated calcium entry2014
- Author(s)
  Oh-hora, M., Lu, X. and Yamasaki, S.
- Organizer
  Keystone Symposia
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] ストア作動性カルシウム流入による免疫制御2014
- Author(s)
  大洞将嗣
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] NFAT2-dependent IL-4-producing follicular helper T cells is a critical factor in Th2 inflammation by the lack of store-operated calcium entry.2014
- Author(s)
  Masatsugu Oh-hora, Xiuyuan Lu, Sho Yamasaki
- Organizer
  Keystone Symposia
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] ストア作動性カルシウム流入の異常による疾患発症のメカニズム2014
- Author(s)
  9. 大洞将嗣, 小松紀子, Anjana Rao, 高柳広
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] STIM1-mediated store operated Ca^<2+> entry is essential for basophil recruitment in IgE-mediated chronic allergic inflammation2013
- Author(s)
  Yoshikawa, S., Oh-hora, M., Miyake, K., Li, L., Ohta, T., Adachi, T., Horiguchi, K., Kawano, Y. and Karasuyama, H.
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Store-operated calcium entry and T cell development.2013
- Author(s)
  Masatsugu Oh-hora, Noriko Komatsu, Anjana Rao, Hiroshi Takayanagi
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Store-operated calcium entry is crucial for the development of agonist-selected T cells.2013
- Author(s)
  Masatsugu Oh-hora, Noriko Komatsu, Anjana Rao, Hiroshi Takayanagi
- Organizer
  FASEB Science Research Conference
- Place of Presentation
  Nassau, Bahamas
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Store-operated calcium entry is crucial for the development of agonist-selected T cells2013
- Author(s)
  Oh-hora, M., Komatsu, N., Rao, A. and Takayanagi, H.
- Organizer
  FASEB Science Research Conference
- Place of Presentation
  Nassau, Bahamas
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] T細胞分化とストア作動性カルシウム流入2013
- Author(s)
  大洞将嗣、小松紀子、Anjana Rao、高柳広
- Organizer
  第２２回東京免疫フォーラム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Store-operated calcium entry and T cell development2013
- Author(s)
  Oh-hora, M., Komatsu, N., Rao, A. and Takayanagi, H.
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] STIM1を介したストア作動性カルシウム流入は好塩基球の脱顆粒および炎症局所への浸潤に重要である2013
- Author(s)
  三宅健介、吉川宗一郎、大洞将嗣、烏山一
- Organizer
  第63回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Strong TCR/calcium signaling specifically controls the development of regulatory T cell subsets2013
- Author(s)
  大洞将嗣、小松紀子、Stefan Feske、堀昌平、Anjana Rao、高柳広
- Organizer
  Frontiers in Immunology and Inflammation
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] STIM1-mediated store operated Ca2+ entry is essential for basophil recruitment in IgE-mediated chronic allergic inflammation.2013
- Author(s)
  Soichiro Yoshikawa, Masatsugu Oh-hora, Kensuke Miyake, Lihua Li, Takuya Ohta, Takahiro Adachi, Kayo Horiguchi, Yohei Kawano, Hajime Karasuyama
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Search for downstream targets of protein kinase D that is critical for T cell development2013
- Author(s)
  Ishikawa, E., Oh-hora, M., Kurosaki, T., Saito, T. and Yamasaki, S.
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Search for downstream targets of protein kinase D that is critical for T cell development.2013
- Author(s)
  Eri Ishikawa, Masatsugu Oh-hora, Tomohiro Kurosaki, Takasi Saito, Sho Yamasaki
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] T細胞分化とストア作動性カルシウム流入2013
- Author(s)
  大洞将嗣、小松紀子、Anjana Rao、高柳広
- Organizer
  第22回東京免疫フォーラム
- Place of Presentation
  東京
- Year and Date
  2013-03-14
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] STIM1を介したストア作動性カルシウム流入は好塩基球の脱下流および炎症局所への浸潤に重要である2013
- Author(s)
  三宅健介, 吉川宗一郎, 大洞将嗣, 烏山一
- Organizer
  第63回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] STIM依存性カルシウム流入によるT細胞の分化制御2012
- Author(s)
  大洞将嗣
- Organizer
  第122回小児血液腫瘍懇話会
- Place of Presentation
  東京
- Year and Date
  2012-11-02
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Agonist-selected T cell development requires strong TCR/calcium signaling2012
- Author(s)
  大洞将嗣、小松紀子、Stefan Feske、堀昌平、Anjana Rao、高柳広
- Organizer
  第４１回日本免疫学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] 小胞体カルシウムセンサーSTIMによるT細胞分化制御2012
- Author(s)
  大洞将嗣
- Organizer
  第8回骨免疫ワークショップ
- Place of Presentation
  東京
- Year and Date
  2012-11-02
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Agonist-selected T cell development requires strong TCR/calcium signaling2012
- Author(s)
  大洞将嗣、小松紀子、高柳広
- Organizer
  第２２回KTCC
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] STIM1-mediated store operated Ca^2+ entry is essential for basophil recruitment in IgE-mediated chronic allergic inflammation2012
- Author(s)
  Yoshikawa, S., Egawa, M., Oh-hora, M., Adachi, T., Horiguchi, K., Li, L., Ohta, T., Kawano, Y., Minagishi, Y. and Karasuyama, H.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Agonist-selected T cell development requires strong TCR/calcium signaling2012
- Author(s)
  Oh-hora, M.,Komastu, N., Feske, S.,Hori, S., Rao, A. and Takayanagi, H.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Lineage-specific requirement of store-operated calcium entry in T cell lineage development2011
- Author(s)
  大洞将嗣
- Organizer
  第21回KTCC
- Place of Presentation
  京都
- Year and Date
  2011-06-10
- Data Source
  KAKENHI-PUBLICLY-22021014
[Presentation] Lineage-specific requirement of store-operated calcium entry in T cell lineage development2011
- Author(s)
  大洞　将嗣
- Organizer
  第21回KTCC
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Agonist-selected T cell development requires strong TCR/calcium signaling2011
- Author(s)
  大洞将嗣、小松紀子、高柳広
- Organizer
  第22回Kyoto T cell conference (KTCC)
- Place of Presentation
  京都
- Year and Date
  2011-06-10
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Different Ca^<2+> sensitivity of the development of T-lineage cells2010
- Author(s)
  Oh-hora M., et al.
- Organizer
  Keystone Symposia
- Place of Presentation
  Breckenridge, Colorado, USA
- Data Source
  KAKENHI-PROJECT-21890069
[Presentation] Lineage-specific requirement of store-operated calcium entry in T-lineage development2010
- Author(s)
  Oh-hora, M., et al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PUBLICLY-22021014
[Presentation] 免疫系におけるストア作動性カルシウム流入の生理的な役割2010
- Author(s)
  大洞将嗣
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PUBLICLY-22021014
[Presentation] 小胞体カルシウムセンサーSTIM によるT細胞分化制御
- Author(s)
  大洞将嗣
- Organizer
  第８回骨免疫ワークショップ
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23590565
[Presentation] Endoplasmic reticulum calcium sensors, Stim1 and Stim2, control dendritic cell functions.
- Author(s)
  Oh-hora M, Lu X, Mori D, Yamasaki S.
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] Calcium signaling in chronic inflammation.
- Author(s)
  Oh-hora M, Lu X, Yamasaki S.
- Organizer
  24th Hot Spring Harbor International Symposium
- Place of Presentation
  福岡
- Year and Date
  2014-11-07 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] Endoplasmic reticulum calcium sensors, Stim1 and Stim2, control dendritic cell functions.
- Author(s)
  Oh-hora M, Lu X, Mori D, Yamasaki S.
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26670125
[Presentation] Molecular mechanism of Ca2+ influx by IgE/antigen stimulation in basophils.
- Author(s)
  Yoshikawa S, Oh-hora M, Wakamori M, Miyake K, Li L, Horiguchi K, Ohta T, Adachi T, Yamanashi Y, Karasuyama H.
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] Molecular mechanism of Ca2+ influx by IgE/antigen stimulation in basophils.
- Author(s)
  Yoshikawa S, Oh-hora M, Wakamori M, Miyake K, Li L, Horiguchi K, Ohta T, Adachi T, Yamanashi Y, Karasuyama H.
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26670125
[Presentation] Mechanism of chronic inflammation by the lack of store-operated calcium entry.
- Author(s)
  Oh-hora M, Lu X, Yamasaki S, Takayanagi H.
- Organizer
  FASEB Science Research Conference
- Place of Presentation
  Nassau, Bahamas
- Year and Date
  2014-06-01 – 2014-06-06
- Data Source
  KAKENHI-PROJECT-26670125
[Presentation] Dectin-2 recognizes mycobacterial lipoarabinomannan and contributes to host defense during infection.
- Author(s)
  Yonekawa A, Saijo S, Miyake Y, Ishikawa E, Suzukawa M, Yoneyama M, Oh-hora M, Yamasaki S.
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26293108
[Presentation] Dectin-2 recognizes mycobacterial lipoarabinomannan and contributes to host defense during infection.
- Author(s)
  Yonekawa A, Saijo S, Miyake Y, Ishikawa E, Suzukawa M, Yoneyama M, Oh-hora M, Yamasaki S.
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26670125
[Presentation] Calcium signaling in chronic inflammation.
- Author(s)
  Oh-hora M, Lu X, Yamasaki S.
- Organizer
  24th Hot Spring Harbor International Symposium
- Place of Presentation
  福岡
- Year and Date
  2014-11-07 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-26670125
[Presentation] Mechanism of chronic inflammation by the lack of store-operated calcium entry.
- Author(s)
  Oh-hora M, Lu X, Yamasaki S, Takayanagi H.
- Organizer
  FASEB Science Research Conferences
- Place of Presentation
  Nassau, Bahamas
- Year and Date
  2014-06-01 – 2014-06-06
- Data Source
  KAKENHI-PROJECT-26293108

1. KUROSAKI Tomohiro (50178125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. HIKIDA Masaki (60228715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Haruyama Naoto (70359529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 小迫英尊 (10291171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 山崎哲男 (90330208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 井鍋一則 (30309215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 寺尾文恵 (10510018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 吉崎恵悟 (10507982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 二階堂まりこ (40707618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 山崎晶

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
11. 高野吉郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 長田貴宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 宮本智文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 烏山一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 田中真二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 赤司浩一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 永安一樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohora Masatsugu 大洞 將嗣

OH-HORA Masatsugu 大洞 將嗣

大洞 将嗣 オオホラ マサツグ

Research Projects

Research Products

Co-Researchers

Elucidation of molecular mechanisms of lymphopoiesis by essential minerals through TRPM7Principal Investigator

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Elucidation of novel molecular mechanisms of early T cell development by regulation of intracellular ion homeostasisPrincipal Investigator

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Molecular basis for the mechanism of ectodermal dysplasia caused by abnormal calcium signaling

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Elucidation of molecular mechanisms of the selection and maturation of thymocytesPrincipal Investigator

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Calcium signal as a potential clinical target for breast cancerPrincipal Investigator

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Elucidation of the role of calcium signaling on peripheral immune tolerance.Principal Investigator

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T系列細胞群の分化・機能におけるカルシウム流入制御機構の解明Principal Investigator

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Research Institution

カルシウム流入制御機構を介した自己免疫疾患発症機序の理解と解析Principal Investigator

Principal Investigator

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Research Institution

Quantitative and qualitative regulation of cellular signaling in immune system

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[Book] 医学のあゆみ2019

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[Book] Calcium entry channels in non-excitable cells2017

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[Book] Chronic Inflammation (Miyasaka M. and Takatsu K., Editors)2016

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[Book] 医学のあゆみ2014

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Total Pages

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Ohora Masatsugu 大洞將嗣

OH-HORA Masatsugu 大洞將嗣

大洞将嗣オオホラマサツグ

[Book] イラストで徹底理解する　シグナル伝達キーワード事典2012

[Book] イラストで徹底理解する　シグナル伝達キーワード事典2012