HORIKAWA Yohei 堀川洋平

Researcher Number	40361232
Affiliation (based on the past Project Information) *help	2009 – 2012: Akita University, 医学部, 講師 2010: 秋田大学, 大学院・医学系研究科, 講師 2006: 秋田大, 医学部, 助手 2003 – 2005: 秋田大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Urology Except Principal Investigator Urology
Keywords	Principal Investigator PSA / 遺伝子多型 / IGFBP3 / IGF-I / gene polymorphism / Prostate cancer / IGFBP-3遺伝子 / PSA遺伝子 / IGFBP3遺伝子 / IGF-I遺伝子 … More / 前立腺癌 / 尿路上皮癌 / 腎細胞癌 / 尿路上皮がん / マイクロRNA / 上皮細胞増殖因子受容体 / E-カドヘリン / 膀胱癌 … More Except Principal Investigator 前立腺癌 / 遺伝子多型 / Genetic polymorphism / Chromosomal alteration / Prostate cancer / 染色体異常 / 腫瘍微小環境 / 分子生物学 / MCP-1 / TWEAK / 高カロリー食 / IGF-1 / 腎細胞癌 / 高脂肪食 / 肥満 / 免疫染色 / IGF-I受容体 / IGF-I / 予後診断 / SNPパネル / 治療標的分子 / SNPアレイ / 予後予測 / 腫瘍学 / ヨード放射線療法 / 遺伝子治療 / NIS / 放射線療法 Less

Delineation of Molecular Mechanisms and Identification of Molecular Therapeutic Targets underlying Progression of Urologic Cancers Associated with High Fat or High Calorie Diet
- Principal Investigator
  
  HABUCHI Tomonori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Akita University
Exploratory study of prognostic and therapeutic target moleculars in advanced prostate cancer
- Principal Investigator
  
  TSUCHIYA Norihiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Akita University
MicroRNA related gene polymorphisms and its function in urinary tract urothelial carcinoma and renal cell carcinomaPrincipal Investigator
- Principal Investigator
  
  HORIKAWA Yohei
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Akita University
膀胱癌におけるE-カドヘリンと上皮細胞増殖因子受容体との関連Principal Investigator
- Principal Investigator
  
  堀川洋平
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Akita University
泌尿器癌を標的としたNIS遺伝子導入^<131>I放射線内照射療法の確立
- Principal Investigator
  
  HABUCHI Tomonori
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Urology
- Research Institution
  Akita University
Exploration for novel biologic markers which predict progression and prognosis of prostate cancer based on chromosomal alterations.
- Principal Investigator
  
  TSUCHIYA Norihiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Akita University
Analysis of IGF-I related gene polymorphisms and their impact on prostate cancer in Japanese populationPrincipal Investigator
- Principal Investigator
  
  HORIKAWA Yohei, 王立忠
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Akita University

All 2012 2011 2010 2009 2008 2005

All Journal Article Presentation

[Journal Article] A high-fat diet enhances proliferation of prostate cancer cells and activates MCP-1/CCR2 signaling2012
- Author(s)
  Huang M, Narita S, Numakura K, Tsuruta H, Saito M, Inoue T, Horikawa Y, Tsuchiya N, Habuchi T.
- Journal Title
  
  Prostate
  
  Volume: 72(16) Pages: 1779-88
- Data Source
  KAKENHI-PROJECT-22390302
[Journal Article] Antitumor effect of sunitinib against skeletal metastatic renal cell carcinoma through inhibition of osteoclast function2012
- Author(s)
  Maita S, Yuasa T, Tsuchiya N, Mitobe Y, Narita S, Horikawa Y, Hatake K, Fukui I, Kimura S, Maekawa T, Habuchi T.
- Journal Title
  
  Int J Cancer
  
  Volume: 130(3) Pages: 677-84
- Data Source
  KAKENHI-PROJECT-22390302
[Journal Article] Outcome, clinical prognostic factors and genetic predictors of adverse reactions of intermittent combination chemotherapy with docetaxel estramustine phosphate and carboplatin for castration-resistant prostate cancer2012
- Author(s)
  Narita S, Tsuchiya N, Yuasa T, Maita S, Obara T, Numakura K, Tsuruta H, Saito M, Inoue T, Horikawa Y, Satoh S, Habuchi T.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 17(3) Pages: 204-11
- NAID
  10030951423
- Data Source
  KAKENHI-PROJECT-22390302
[Journal Article] Antitumor effect of sunitinib against skeletal metastatic renal cell carcinoma through inhibition of osteoclast function.2011
- Author(s)
  Maita S, Yuasa T, Tsuchiya N, Mitobe Y, Narita S, Horikawa Y, et al.
- Journal Title
  
  Int J Cancer Epub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791486
[Journal Article] A Novel Strategy for Evasion of NK Cell Immunity by Tumours Expressing Core2 O-glycans2011
- Author(s)
  Tsuboi S, Sutoh M, Hatakeyama S, Hiraoka N, Habuchi T, Horikawa Y, Hashimoto Y, Yoneyama T, Mori K, Koie T, Nakamura T, Saitoh H, Yamaya K, Funyu T, Fukuda M, Ohyama C.
- Journal Title
  
  EMBO J.
  
  Volume: 30(15) Pages: 3173-85
- Data Source
  KAKENHI-PROJECT-22390302
[Journal Article] Two survivin polymorphisms are cooperatively associated with bladder cancer susceptibility2011
- Author(s)
  Kawata N, Tsuchiya N, Horikawa Y, Inoue T, Tsuruta H, Maita S, Sato S, Mitobe Y, Narita S, Habuchi T.
- Journal Title
  
  Int J Cancer
  
  Volume: 129(8) Pages: 1872-80
- Data Source
  KAKENHI-PROJECT-22390302
[Journal Article] Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome2011
- Author(s)
  Huang M, Narita S, Tsuchiya N, Ma Z, Numakura K, Obara T, Tsuruta H, Saito M, Inoue T, Horikawa Y, Satoh S, Habuchi T.
- Journal Title
  
  Carcinogenesis
  
  Volume: 32(11) Pages: 1589-96
- Data Source
  KAKENHI-PROJECT-22390302
[Journal Article] Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma.2010
- Author(s)
  Lin J, Horikawa Y, Tamboli P, et al
- Journal Title
  
  Carcinogenesis 31
  
  Pages: 1805-1812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791486
[Journal Article] Clinical significance of polymorphism and expression of chromogranin a and endothelin-1 in prostate cancer2010
- Author(s)
  Ma Z, Tsuchiya N, Yuasa T, Huang M, Obara T, Narita S, Horikawa Y, Tsuruta H, Saito M, Satoh S, Ogawa O, Habuchi T.
- Journal Title
  
  J Urol
  
  Volume: 184(3) Pages: 1182-8
- Data Source
  KAKENHI-PROJECT-22390302
[Journal Article] Two survivin polymorphisms are cooperatively associated with bladder cancer susceptibility.2010
- Author(s)
  Kawata N, Tsuchiya N, Horikawa Y, et al.
- Journal Title
  
  Int J Cancer Epub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791486
[Journal Article] Clinical significance of polymorphism and expression of chromogranin A and endothelin-1 in prostate cancer.2010
- Author(s)
  Ma Z, Tsuchiya N, Yuasa T, Huang M, Obara T, Narita S, Horikawa Y, et al.
- Journal Title
  
  J Urol 184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791486
[Journal Article] Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma.2010
- Author(s)
  Lin J, Horikawa Y., et al.
- Journal Title
  
  Carcinogenesis
  
  Volume: 31 Pages: 1805-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791486
[Journal Article] Clinical significance of a single nucleotide polymorphism and allelic imbalance of matrix metalloproteinase-1 promoter region in prostate cancer2009
- Author(s)
  Tsuchiya N, Narita S, Kumazawa T, Inoue T, Ma Z, Tsuruta H, Saito M, Horikawa Y, Yuasa T, Satoh S, Ogawa O, Habuchi T.
- Journal Title
  
  Oncol Rep
  
  Volume: 22(3) Pages: 493-9
- Data Source
  KAKENHI-PROJECT-22390302
[Journal Article] The novel tumor-suppressor Mel-18 in prostate cancer: Its functional polymorphism, expression, and clinical significance2009
- Author(s)
  Wang W, Yuasa T, Tsuchiya N, Ma Z, Maita S, Narita S, Kumazawa T, Inoue T, Tsuruta H, Horikawa Y, Saito M, Hu W, Ogawa O, Habuchi T
- Journal Title
  
  Int J Cancer
  
  Volume: 125(12) Pages: 2836-43
- Data Source
  KAKENHI-PROJECT-22390302
[Journal Article] Upreguration of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis.2009
- Author(s)
  Chen Y, Zhang H, Gou X, Horikawa Y, Xing J, Chen Z.
- Journal Title
  
  Cancer Lett 278
  
  Pages: 113-121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791486
[Journal Article] The novel tumor-suppressor Mel-18 in prostate cancer :its functional polymorphism, expression and clinical significance.2009
- Author(s)
  Wang W, Yuasa T, Tsuchiya N, Ma Z, Maita S, Narita S, Kumazawa T, Inoue T, Tsuruta H, Horikawa Y, et al.
- Journal Title
  
  Int J Cancer 15
  
  Pages: 2836-2843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791486
[Journal Article] A genetic polymorphism of the osteoprotegerin gene is associated with an increased risk of advanced prostate cancer2008
- Author(s)
  Narita N, Yuasa T, Tsuchiya N, Kumazawa T, Narita S, Inoue T, Ma Z, Saito M, Horikawa Y, Satoh S, Ogawa O, Habuchi T
- Journal Title
  
  BMC Cancer
  
  Volume: 8 Pages: 224-224
- Data Source
  KAKENHI-PROJECT-22390302
[Journal Article] Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prostate cancer in a Japanese population2008
- Author(s)
  Ma Z, Tsuchiya N, Yuasa T, Inoue T, Kumazawa T, Narita S, Horikawa Y, Tsuruta H, Obara T, Saito M, Satoh S, Ogawa O, Habuchi T.
- Journal Title
  
  Int J Cancer
  
  Volume: 123(11) Pages: 2574-2579
- Data Source
  KAKENHI-PROJECT-22390302
[Journal Article] CA repeat polymorphism in the insulin-like growth factor-I gene is associated with increased risk of prostate cancer and benign prostatic hyperplasia.2005
- Author(s)
  Tsuchiya N, Wang L, Horikawa Y et al.
- Journal Title
  
  International Journal of Oncology. 26(1)
  
  Pages: 225-231
- Data Source
  KAKENHI-PROJECT-15591667
[Journal Article] CA repeat polymorphism in the insulin-like growth factor-I gene is associated with increased risk of prostate cancer and benign prostatic hyperplasia.2005
- Author(s)
  Tsuchiya N, Wang L, Horikawa Y et al.
- Journal Title
  
  International Journal of Oncology 26(1)
  
  Pages: 225-231
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591667
[Presentation] Prediction of survival in metastatic prostate cancer patients by single nucleotide polymorphisms of cancer-associated genes2012
- Author(s)
  Yohei Horikawae, et al.
- Organizer
  International EAUN Meeting
- Place of Presentation
  Paris
- Year and Date
  2012-02-25
- Data Source
  KAKENHI-PROJECT-21592029
[Presentation] Functional genetic polymorphisms in the CYP19 gene decrease the risk of prostate cancer and alter the response to androgen deprovation therapy2012
- Author(s)
  Kanda, S., Tsuchiya, N., Kou, M., Chiba, S., Satoyoshi, K., Maita, S., Numakura, K., Obara, T., Inoue, T., Narita, S., Horikawa, Y., Satoh, S.and Habuchi, N.
- Organizer
  The 107th annual meeting of the American Urological Association
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-22390302
[Presentation] Stimulation of macrophage inhibitory cytokine-1 by palmitic acid activates prostate cancer cell invasiveness2012
- Author(s)
  Huang, M., Narita, S., Maita, S., Numakura, K., Obara, T., Inoue, T., Horikawa, Y., Satoh, S.and Habuchi, T.
- Organizer
  The 107th annual meeting of the American Urological Association
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-22390302
[Presentation] Prediction of Survival in Metastatic Prostate Cancer Patients by SNP Array Analysis of Cancer-Associated Genes2011
- Author(s)
  Tsuchiya, N., Matsui, S., Narita, S., Inoue, T., Numakura, K., Horikawa, Y., Hatakeyama, S., Ogawa, O., Arai, Y., Saito, S., Ohyama, C., Habuchi, T.
- Organizer
  The 106th Annunal Meeting of the American Urological Association
- Place of Presentation
  Washisnton DC, USA
- Data Source
  KAKENHI-PROJECT-22390302
[Presentation] Prostate cancer progression under high fat diet is enhanced by the MCP-1/CCR2 signaling2011
- Author(s)
  Huang, M., Narita, S., Numakura, K., Tsuruta, H., Saito, M., Inoue, T., Horikawa, Y., Tsuchiya, N., Habuchi, T.
- Organizer
  The 106th Annunal Meeting of the American Urological Association
- Place of Presentation
  Washisnton DC, USA
- Data Source
  KAKENHI-PROJECT-22390302
[Presentation] INSULIN-LIKE GROWTH FACTOR-I (IGF-I) POLYMORPHISMS PREDICT THE SURVIVAL OF PROSTATE CANCER PATIENTS WITH BONE METASTASIS AT INITIAL PRESENTATION2010
- Author(s)
  Tsuchiya, N., Narita, S., Ma, Z., Horikawa, Y., Tsuruta, H., Numakura, K., Saito, M., Satoh, S., Inoue, T., Ogawa, O., Habuchi. T.
- Organizer
  The 105th Annual Meeting of the American Urological Association
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-22390302
[Presentation] Polymorphisms in the XRCC1 and MDM2 genes may be associated with recurrence in non-muscle invasive bladder cancer.2010
- Author(s)
  Horikawa Y, et al.
- Organizer
  The 106st Annual Meeting of the American Urological Association
- Place of Presentation
  April, Sanfrancisco
- Data Source
  KAKENHI-PROJECT-21791486
[Presentation] GENETIC POLYMORPHISM INFLUENCES INDIVIDUAL VARIATIONS IN SERUM TESTOSTERONE LEVELS IN PROSTATE CANCER PATIENTS TREATED WITH ANDROGEN DEPRIVATION THERAPY2010
- Author(s)
  Narita, S., Numakura, K., Obara, T., Tsuruta, H., Saito, M., Horikawa, Y., Tsuchiya, N., Habuchi, T.
- Organizer
  The 105th Annual Meeting of the American Urological Association, May
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-22390302
[Presentation] TWEAK-FN14 SIGNALING REGULATES ANDROGEN-INDEPENDENT PROSTATE CANCER CELL INVASIVENESS AND CORRELATES WITH POOR PATIENT OUTCOME2010
- Author(s)
  Mingguo, H., Narita, S., Ma, Z., Numakura, K., Obara, T., Tsuruta, H., Saito, M., Horikawa, Y., Tsuchiya, N., Habuchi, T.
- Organizer
  The 105th Annual Meeting of the American Urological Association
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-22390302
[Presentation] Clinical implications of the MDM2 SNP309 and p53 Arg72Pro polymorphisms in trantitional cell carcinoma of the bladder.2009
- Author(s)
  Horikawa Y, et al.
- Organizer
  The 105st Annual Meeting of the American Urological Association
- Place of Presentation
  April, Chicago
- Data Source
  KAKENHI-PROJECT-21791486

1. HABUCHI Tomonori (00293861)

# of Collaborated Projects: 5 results

# of Collaborated Products: 18 results
2. TSUCHIYA Norihiko (70282176)

# of Collaborated Projects: 5 results

# of Collaborated Products: 18 results
3. NARITA Shintaro (40396552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. OHYAMA Chikara (80282135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. YUASA Takeshi (00314162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. NANJO Hiroshi (70250892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TOGASHI Hisafumi (30361231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 柿沼秀秋 (70323144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 王立忠 (00344755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 佐藤一成 (90270842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HORIKAWA Yohei 堀川 洋平

Research Projects

Research Products

Co-Researchers

Delineation of Molecular Mechanisms and Identification of Molecular Therapeutic Targets underlying Progression of Urologic Cancers Associated with High Fat or High Calorie Diet

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploratory study of prognostic and therapeutic target moleculars in advanced prostate cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MicroRNA related gene polymorphisms and its function in urinary tract urothelial carcinoma and renal cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

膀胱癌におけるE-カドヘリンと上皮細胞増殖因子受容体との関連Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

泌尿器癌を標的としたNIS遺伝子導入^<131>I放射線内照射療法の確立

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploration for novel biologic markers which predict progression and prognosis of prostate cancer based on chromosomal alterations.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of IGF-I related gene polymorphisms and their impact on prostate cancer in Japanese populationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A high-fat diet enhances proliferation of prostate cancer cells and activates MCP-1/CCR2 signaling2012

Author(s)

Journal Title

Data Source

[Journal Article] Antitumor effect of sunitinib against skeletal metastatic renal cell carcinoma through inhibition of osteoclast function2012

Author(s)

Journal Title

Data Source

[Journal Article] Outcome, clinical prognostic factors and genetic predictors of adverse reactions of intermittent combination chemotherapy with docetaxel estramustine phosphate and carboplatin for castration-resistant prostate cancer2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Antitumor effect of sunitinib against skeletal metastatic renal cell carcinoma through inhibition of osteoclast function.2011

Author(s)

Journal Title

Data Source

[Journal Article] A Novel Strategy for Evasion of NK Cell Immunity by Tumours Expressing Core2 O-glycans2011

Author(s)

Journal Title

Data Source

[Journal Article] Two survivin polymorphisms are cooperatively associated with bladder cancer susceptibility2011

Author(s)

Journal Title

Data Source

[Journal Article] Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome2011

Author(s)

Journal Title

Data Source

[Journal Article] Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma.2010

Author(s)

Journal Title

Data Source

[Journal Article] Clinical significance of polymorphism and expression of chromogranin a and endothelin-1 in prostate cancer2010

HORIKAWA Yohei 堀川洋平