NAGANO SEIICHI 長野清一

… Alternative Names

NAGANO Seiichi 長野清一

長野清一ナガノセイイチ

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Researcher Number	40362727
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 特任教授(常勤) 2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第五部, 客員研究員
Affiliation (based on the past Project Information) *help	2021 – 2024: 大阪大学, 大学院医学系研究科, 寄附講座教授 2017 – 2019: 大阪大学, 医学系研究科, 准教授 2017: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第五部, 室長 2016: 大阪大学, 医学系研究科, 講師 2015: 国立研究開発法人国立精神・神経医療研究センター, 疾病研究第5部, 室長 … More 2015: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第五部, 室長 2012 – 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第五部, 室長 2010 – 2011: 独立行政法人国立精神・神経医療研究センター, 神経研究所・疾病研究第五部, 室長 2004 – 2005: 大阪大学, 医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52020:Neurology-related / Complex systems / Medium-sized Section 52:General internal medicine and related fields / Biological Sciences Except Principal Investigator Basic Section 57060:Surgical dentistry-related / General internal medicine(including psychosomatic medicine)
Keywords	Principal Investigator 筋萎縮性側索硬化症 / 前頭側頭葉変性症 / TDP-43 / 局所翻訳 / mRNA / IMAC / CCS / 銅 / SOD1 / 鉄代謝 … More / フェリチン / シングルセル解析 / スプライシング / RNA-seq / 神経軸索 / リボソーム蛋白質mRNA / リボソーム蛋白質 / 軸索輸送 / 神経突起輸送 / 神経突起 / RNA / システイン / 蛍光X線分析 … More Except Principal Investigator 遺伝子治療 / 咀嚼障害 / 筋萎縮性側索硬化症 / ALS / タウ / βアミロイド / 認知症 / ゲノム編集 / 遺伝子 / 糖尿病 / アルツハイマー病 Less

患者組織由来RNA-seqの統合的解析によるALS病態関連因子の同定Principal Investigator
- Principal Investigator
  
  長野清一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Development of a Novel ALS Therapeutic Strategy Targeting Primary Sensory Neurons
- Principal Investigator
  
  関壮樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Osaka University
細胞種特異的スプライシング変化を介したALS発症機序の解明Principal Investigator
- Principal Investigator
  
  長野清一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Osaka University
神経細胞内鉄代謝障害に基づく筋萎縮性側索硬化症の病態解明Principal Investigator
- Principal Investigator
  
  長野清一
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Osaka University
Elucidation of the pathogenesis and development of the treatment strategy of ALS/FTLD focusing on the local translation in neuronal axonsPrincipal Investigator
- Principal Investigator
  
  長野清一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Investigation of ALS/FTLD pathogenesis based on translational deterioration due to ribosome dysfunction in axonsPrincipal Investigator
- Principal Investigator
  
  NAGANO Seiichi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
Investigation of key molecules involved in bidirectional interactions between diabetes and dementia
- Principal Investigator
  
  SATO Naoyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  National Center for Geriatrics and Gerontology
  Osaka University
Pathogenesis of TDP-43 proteinopathy based on the transport defect of target mRNAPrincipal Investigator
- Principal Investigator
  
  Nagano Seiichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry
Elucidation of the neuronal toxicity mechanism by TDP-43 based on dysfunction of the nucleocytoplasmic shuttlingPrincipal Investigator
- Principal Investigator
  
  NAGANO Seiichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry
家族性筋萎縮性側索硬化症における変異SOD1特異的銅親和性の解析Principal Investigator
- Principal Investigator
  
  長野清一
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
家族性筋萎縮性側索硬化症における変異SOD1特異的銅親和性の解析Principal Investigator
- Principal Investigator
  
  長野清一
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Osaka University

[Book] 今日の治療指針2020
- Author(s)
  長野清一，望月秀樹．
- Total Pages
  2192
- Publisher
  医学書院
- ISBN
  9784260039390
- Data Source
  KAKENHI-PROJECT-16K09690
[Book] Annual Review 神経 20182018
- Author(s)
  長野清一、望月秀樹
- Total Pages
  344
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-16K09690
[Book] 神経変性疾患ハンドブック2018
- Author(s)
  長野清一，望月秀樹．
- Total Pages
  406
- Publisher
  南江堂
- ISBN
  9784524256174
- Data Source
  KAKENHI-PROJECT-16K09690
[Book] Novel Aspects of Amyotrophic Lateral Sclerosis2016
- Author(s)
  Nagano S, Araki T.
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-25461302
[Book] Update on amyotrophic lateral sclerosis2016
- Author(s)
  Nagano S, Araki T.
- Total Pages
  278
- Publisher
  InTech Publisher
- Data Source
  KAKENHI-PROJECT-16K09690
[Book] 実験医学別冊「マウス表現型解析スタンダード」2016
- Author(s)
  長野清一，金井雅裕，永井義隆．
- Total Pages
  351
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-16K09690
[Book] Oxidative modifications of Cu, Zn-superoxide dismutase (SOD1)-the relevance to amyotrophic lateral sclerosis (ALS). In "Amyotrophic Lateral Sclerosis"2012
- Author(s)
  Nagano S.
- Total Pages
  718
- Publisher
  InTech Publisher
- Data Source
  KAKENHI-PROJECT-22590932
[Book] Amyotrophic Lateral Sclerosis2012
- Author(s)
  Nagano S
- Publisher
  InTech Publisher
- Data Source
  KAKENHI-PROJECT-22590932
[Journal Article] Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.2024
- Author(s)
  Ueda T, Takeuchi T, Fujikake N, Suzuki M, Minakawa EN, Ueyama M, Fujino Y, Kimura N, Nagano S, Yokoseki A, Onodera O, Mochizuki H, Mizuno T, Wada K, Nagai Y.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 12 Issue: 1 Pages: 20-20
- DOI
  10.1186/s40478-024-01729-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K19762, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PROJECT-21H02840
[Journal Article] 筋萎縮性側索硬化症におけるmRNA神経軸索輸送を介した局所翻訳機構の役割．2023
- Author(s)
  長野清一．
- Journal Title
  
  細胞
  
  Volume: 55 Pages: 858-861
- Data Source
  KAKENHI-PROJECT-21H02841
[Journal Article] Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism2023
- Author(s)
  Choong Chi-Jing、Aguirre Cesar、Kakuda Keita、Beck Goichi、Nakanishi Hiroki、Kimura Yasuyoshi、Shimma Shuichi、Nabekura Kei、Hideshima Makoto、Doi Junko、Yamaguchi Keiichi、et al.
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 145 Issue: 5 Pages: 573-595
- DOI
  10.1007/s00401-023-02555-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-20K06910, KAKENHI-PROJECT-23K24212, KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K15709, KAKENHI-PROJECT-22K07516, KAKENHI-PROJECT-22K07538, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K23848
[Journal Article] Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.2023
- Author(s)
  Takeuchi T., Maeta K., Xin D., Oe Y., Takeda A., Inoue M., Nagano S., Fujihara T., Matsuda S., Ishigaki S., Sahashi K., Minakawa E.N., Mochizuki H., Neya M., Sobue G., *Nagai Y.
- Journal Title
  
  Mol. Ther. Nucleic Acids
  
  Volume: 31 Pages: 353-366
- DOI
  10.1016/j.omtn.2023.01.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K18265, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811
[Journal Article] 神経変性疾患に対する遺伝子治療の現況．2023
- Author(s)
  長野清一，望月秀樹．
- Journal Title
  
  医学のあゆみ
  
  Volume: 285 Pages: 435-439
- Data Source
  KAKENHI-PROJECT-23K18265
[Journal Article] RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.2023
- Author(s)
  Shimizu M, Shiraishi N, Tada S, Sasaki T, Beck G, Nagano S, Kinoshita M, Sumi H, Sugimoto T, Ishida Y, Koda T, Ishikura T, Sugiyama Y, Kihara K, Kanakura M, Nakajima T, Takeda S, Takahashi MP, Yamashita T, Okuno T, Mochizuki H.
- Journal Title
  
  Sci Adv
  
  Volume: 9 Issue: 47 Pages: 1-17
- DOI
  10.1126/sciadv.adg3193
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K07539, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PROJECT-23K21405, KAKENHI-PROJECT-23K27517
[Journal Article] Crosstalk between Oxidatibve Stress and Aging in Neurodegeneration Disorders.2023
- Author(s)
  Abdelhamid RF, Nagano S.
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 5 Pages: 753-753
- DOI
  10.3390/cells12050753
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811
[Journal Article] 筋萎縮性側索硬化症におけるmRNA神経軸索輸送を介した局所翻訳機構の役割．2023
- Author(s)
  長野清一．
- Journal Title
  
  細胞
  
  Volume: 55 Pages: 858-861
- Data Source
  KAKENHI-PROJECT-23K18265
[Journal Article] 神経変性疾患に対する遺伝子治療の現況．2023
- Author(s)
  長野清一，望月秀樹．
- Journal Title
  
  医学のあゆみ
  
  Volume: 285 Pages: 435-439
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Journal Article] Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles2023
- Author(s)
  Kakuda Keita、Ikenaka Kensuke、Kuma Akiko、Doi Junko、Aguirre Cesar、Wang Nan、Ajiki Takahiro、Choong Chi-Jing、Kimura Yasuyoshi、Badawy Shaymaa Mohamed Mohamed、Shima Takayuki、Nakamura Shuhei、Baba Kousuke、Nagano Seiichi、Nagai Yoshitaka、Yoshimori Tamotsu、Mochizuki Hideki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 121 Issue: 1
- DOI
  10.1073/pnas.2312306120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18255, KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K15709, KAKENHI-PROJECT-22KJ2105, KAKENHI-PROJECT-22K07516, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PLANNED-21H05145, KAKENHI-PROJECT-22H04982, KAKENHI-PROJECT-21H02428, KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K24212
[Journal Article] 筋萎縮性側索硬化症におけるmRNA神経軸索輸送を介した局所翻訳機構の役割．2023
- Author(s)
  長野清一．
- Journal Title
  
  細胞
  
  Volume: 55 Pages: 858-861
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Journal Article] 神経変性疾患に対する遺伝子治療の展望．2023
- Author(s)
  長野清一，望月秀樹．
- Journal Title
  
  実験医学増刊「いま新薬で加速する神経変性疾患研究」
  
  Volume: 41 Pages: 2020-2026
- Data Source
  KAKENHI-PROJECT-23K18265
[Journal Article] 神経変性疾患に対する遺伝子治療の現況．2023
- Author(s)
  長野清一，望月秀樹．
- Journal Title
  
  医学のあゆみ
  
  Volume: 285 Pages: 435-439
- Data Source
  KAKENHI-PROJECT-21H02841
[Journal Article] 神経変性疾患に対する遺伝子治療の展望．2023
- Author(s)
  長野清一，望月秀樹．
- Journal Title
  
  実験医学増刊「いま新薬で加速する神経変性疾患研究」
  
  Volume: 41 Pages: 2020-2026
- Data Source
  KAKENHI-PROJECT-21H02841
[Journal Article] An Exploratory Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS): Protocol for a Multicenter, Open-Labeled, 24-Week, Single-Group Study.2023
- Author(s)
  Haji S, Fujita K, Oki R, Osaki Y, Miyamoto R, Morino H, Nagano S, Atsuta N, Kanazawa Y, Matsumoto Y, Arisawa A, Kawai H, Sato Y, Sakaguchi S, Yagi K, Hamatani T, Kagimura T, Yanagawa H, Mochizuki H, Doyu M, Sobue G, Harada M, Izumi Y.
- Journal Title
  
  JMIR Res Protoc.
  
  Volume: 12 Pages: e42032-e42032
- DOI
  10.2196/42032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07359, KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-23K06975, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811
[Journal Article] 神経変性疾患に対する遺伝子治療の展望．2023
- Author(s)
  長野清一，望月秀樹．
- Journal Title
  
  実験医学増刊「いま新薬で加速する神経変性疾患研究」
  
  Volume: 41 Pages: 2020-2026
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Journal Article] Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1.2022
- Author(s)
  Eltahir MK, Nakamori M, Hattori S, Kimura T, Mochizuki H, Nagano S.
- Journal Title
  
  PLoS One
  
  Volume: 17 Issue: 7 Pages: e0269683-e0269683
- DOI
  10.1371/journal.pone.0269683
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02841
[Journal Article] piRNA/PIWI Protein Complex as a Potential Biomarker in Sporadic Amyotrophic Lateral Sclerosis2022
- Author(s)
  Abdelhamid Rehab F.、Ogawa Kotaro、Beck Goichi、Ikenaka Kensuke、Takeuchi Eriko、Yasumizu Yoshiaki、Jinno Jyunki、Kimura Yasuyoshi、Baba Kousuke、Nagai Yoshitaka、Okada Yukinori、Saito Yuko、Murayama Shigeo、Mochizuki Hideki、Nagano Seiichi
- Journal Title
  
  Molecular Neurobiology
  
  Volume: 59 Issue: 3 Pages: 1693-1705
- DOI
  10.1007/s12035-021-02686-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06910, KAKENHI-PROJECT-22K07538, KAKENHI-PROJECT-22K07550, KAKENHI-PROJECT-19K07988, KAKENHI-PROJECT-21H02841, KAKENHI-PROJECT-22H04923
[Journal Article] Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis.2022
- Author(s)
  Ikenaka K, Maeda Y, Hotta Y, Nagano S, Yamada S, Ito D, Torii R, Kakuda K, Tatebe H, Atsuta N, Aguirre C, Kimura Y, Baba K, Tokuda T, Katsuno M, Kimura K, Sobue G, Mochizuki H.
- Journal Title
  
  Eur J Neurol.
  
  Volume: 29（5） Issue: 5 Pages: 1410-1416
- DOI
  10.1111/ene.15254
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07359, KAKENHI-PROJECT-21H02841
[Journal Article] MDMX elevation by a novel Mdmx?p53 interaction inhibitor mitigates neuronal damage after ischemic stroke2022
- Author(s)
  Yan Haomin、Sasaki Tsutomu、Kanki Hideaki、Hirata Yoshiyuki、Nishiyama Kumiko、Hisada Sunao、Matsumura Shigenobu、Nagaoka Yasuo、Sumiyoshi Takaaki、Nagano Seiichi、Nakata Akiko、Yoshida Minoru、Uesato Shinichi、Mochizuki Hideki
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 21110-21110
- DOI
  10.1038/s41598-022-25427-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07414, KAKENHI-PROJECT-21H02841, KAKENHI-PROJECT-19H05640
[Journal Article] Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson’s disease2022
- Author(s)
  Hideshima Makoto、Kimura Yasuyoshi、Aguirre Cesar、Kakuda Keita、Takeuchi Toshihide、Choong Chi-Jing、Doi Junko、Nabekura Kei、Yamaguchi Keiichi、Nakajima Kichitaro、Baba Kousuke、Nagano Seiichi、Goto Yuji、Nagai Yoshitaka、Mochizuki Hideki、Ikenaka Kensuke
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 351-351
- DOI
  10.1038/s41598-021-04131-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17034, KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-21H02841
[Journal Article] Characteristic Features of FUS Inclusions in Spinal Motor Neurons of Sporadic Amyotrophic Lateral Sclerosis.2020
- Author(s)
  Ikenaka K, Ishigaki S, Iguchi Y, Kawai K, Fujioka Y, Yokoi S, Abdelhamid RF, Nagano S, Mochizuki H, Katsuno M, Sobue G.
- Journal Title
  
  J Neuropathol Exp Neurol
  
  Volume: 79 Issue: 4 Pages: 370-377
- DOI
  10.1093/jnen/nlaa003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-17K09753, KAKENHI-PROJECT-18K07367, KAKENHI-PROJECT-20H03589
[Journal Article] Altered immunoreactivity of ErbB4, a causative gene product for ALS19, in the spinal cord of patients with sporadic ALS2019
- Author(s)
  Takahashi Yuji、Uchino Akiko、Shioya Ayako、Sano Terunori、Matsumoto Chihiro、Numata‐Uematsu Yurika、Nagano Seiichi、Araki Toshiyuki、Murayama Shigeo、Saito Yuko
- Journal Title
  
  Neuropathology
  
  Volume: 39 Issue: 4 Pages: 268-278
- DOI
  10.1111/neup.12558
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08006, KAKENHI-PROJECT-19K16970, KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-16H06277
[Journal Article] Critical role of CRAG, a splicing variant of centaurin-γ3/AGAP3, in ELK1-dependent SRF activation at PML bodies.2019
- Author(s)
  Nagashima S, Takeda K, Shiiba I, Higashi M, Fukuda T, Tokuyama T, Matsushita N, Nagano S, Araki T, Kaneko M, Shioi G, Inatome R, Yanagi S.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 20107-20107
- DOI
  10.1038/s41598-019-56559-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-17K08793, KAKENHI-PROJECT-19K16527
[Journal Article] Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid.2019
- Author(s)
  2. Kakuda K, Ikenaka K, Araki K, So M, Aguirre C, Kajiyama Y, Konaka K, Noi K, Baba K, Tsuda H, Nagano S, Ohmichi T, Nagai Y, Tokuda T, El-Agnaf O, Ogi H, Goto Y, Mochizuki H.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 6001-6001
- DOI
  10.1038/s41598-019-42399-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-17K16122, KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-16K09716, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-18H02718, KAKENHI-PROJECT-18H02741
[Journal Article] Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A.2019
- Author(s)
  3. Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
- Journal Title
  
  Neurosci Res
  
  Volume: 139 Pages: 63-68
- DOI
  10.1016/j.neures.2018.08.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-17K19945, KAKENHI-PROJECT-17H00892, KAKENHI-PROJECT-16H06276
[Journal Article] 筋萎縮性側索硬化症とRNA代謝異常．2019
- Author(s)
  長野清一，望月秀樹．
- Journal Title
  
  日本医事新報
  
  Volume: 4964 Pages: 48-48
- Data Source
  KAKENHI-PROJECT-16K09690
[Journal Article] Structurally Distinct α‐Synuclein Fibrils Induce Robust Parkinsonian Pathology2019
- Author(s)
  Hayakawa Hideki、Nakatani Rie、Ikenaka Kensuke、Aguirre Cesar、Choong Chi‐Jing、Tsuda Hiroshi、Nagano Seiichi、Koike Masato、Ikeuchi Takeshi、Hasegawa Masato、Papa Stella M.、Nagai Yoshitaka、Mochizuki Hideki、Baba Kousuke
- Journal Title
  
  Movement Disorders
  
  Volume: 35 Issue: 2 Pages: 256-267
- DOI
  10.1002/mds.27887
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09299, KAKENHI-PROJECT-18H02718, KAKENHI-PROJECT-18H02741, KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16K19512, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325
[Journal Article] 筋萎縮性側索硬化症に対する肝細胞増殖因子を用いた治験．2019
- Author(s)
  長野清一，割田　仁，望月秀樹，青木正志．
- Journal Title
  
  神経治療学
  
  Volume: 36 Pages: 462-464
- NAID
  130007834999
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09690
[Journal Article] A clinicopathological study of ALS with L126S mutation in the SOD1 gene presenting with isolated inferior olivary hypertrophy2019
- Author(s)
  Hideshima Makoto、Beck Goichi、Yamadera Misaki、Motoyama Yuichi、Ikenaka Kensuke、Kakuda Keita、Tsuda Hiroshi、Nagano Seiichi、Fujimura Harutoshi、Morii Eiichi、Murayama Shigeo、Mochizuki Hideki
- Journal Title
  
  Neuropathology
  
  Volume: Epub Issue: 2 Pages: 191-195
- DOI
  10.1111/neup.12620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02718, KAKENHI-PROJECT-16K09690
[Journal Article] 筋萎縮性側索硬化症とRNA代謝異常2018
- Author(s)
  長野清一、望月秀樹
- Journal Title
  
  日本医事新報
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-16K09690
[Journal Article] 大脳皮質基底核変性症―歴史と概要．2017
- Author(s)
  長野清一，望月秀樹．
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 35 Pages: 302-303
- Data Source
  KAKENHI-PROJECT-16K09690
[Journal Article] Transgenic monkey model of the polyglutamine diseases recapitulating progressive neurological symptoms.2017
- Author(s)
  Tomioka I, Ishibashi H, Minakawa EN, Motohashi HH, Takayama O, Saito Y, Popiel HA, Puentes S, Owari K, Nakatani T, Nogami N, Yamamoto K, Noguchi S, Yonekawa T, Tanaka Y, Fujita N, Suzuki H, Kikuchi H, Aizawa S, Nagano S, Yamada D, Nishino I, Ichinohe N, Wada K, Kohsaka S, Nagai Y, Seki K.
- Journal Title
  
  eNeuro
  
  Volume: 4 Issue: 2 Pages: 0250-56
- DOI
  10.1523/eneuro.0250-16.2017
- NAID
  120007100051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-16K09734, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-26870884, KAKENHI-PLANNED-25117009, KAKENHI-PROJECT-16H06277
[Journal Article] A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: relevance to the pathogenesis of ALS2015
- Author(s)
  Nagano S, Takahashi Y, Yamamoto K, Masutani H, Fujiwara N, Urushitani M, Araki T
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 0n line Issue: 12 Pages: 1-13
- DOI
  10.1093/hmg/ddv093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460386, KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-25461302
[Journal Article] Misfolded SOD1 forms high-density molecular complexes with synaptic molecules in mutant SOD1-linked familial amyotrophic lateral sclerosis cases2012
- Author(s)
  Araki T, Nagano S, Tateno M, Kaido M, Ogata K, Arima K
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 314 Issue: 1-2 Pages: 92-96
- DOI
  10.1016/j.jns.2011.10.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590932
[Journal Article] ショウジョウバエなど小動物を用いた筋萎縮性側索硬化症モデル2012
- Author(s)
  藤掛伸宏, 長野清一, 永井義隆
- Journal Title
  
  神経内科
  
  Volume: 76 Pages: 266-274
- Data Source
  KAKENHI-PROJECT-22590932
[Journal Article] Zn-superoxide dismutase induces oxidative stress through aberrant Cu binding2010
- Author(s)
  Kishigami H, Nagano S, Bush AI, Sakoda S. Monomerized Cu
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 48 Issue: 7 Pages: 945-952
- DOI
  10.1016/j.freeradbiomed.2010.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590932
[Journal Article] Monomerized Cu, Zn-superoxide dismutase induces oxidative stress through aberrant Cu binding.2010
- Author(s)
  Kishigami H, Nagano S, Bush AI, Sakoda S.
- Journal Title
  
  Free Radical Biology & Medicine
  
  Volume: 48巻 Pages: 945-952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590932
[Journal Article] Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and nerates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease.2004
- Author(s)
  Nagano S, Huang X, Moir RD et al.
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 14673-14678
- Data Source
  KAKENHI-PROJECT-16790488
[Journal Article] Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and nerates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease.2004
- Author(s)
  Nagano S, Huang X, Moir RD et al.
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 14673-14678
- Data Source
  KAKENHI-PROJECT-16015273
[Patent] 筋萎縮性側索硬化症を含む神経疾患の予防剤及び／又は治療剤2018
- Inventor(s)
  望月秀樹、長野清一、佐々木勉、鐘其静、岡田尚巳、平井幸彦
- Industrial Property Rights Holder
  望月秀樹、長野清一、佐々木勉、鐘其静、岡田尚巳、平井幸彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-141692
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K09690
[Patent] TDP-43プロテイノパチー治療用組成物2016
- Inventor(s)
  長野清一、荒木敏之、上山盛夫、永井義隆
- Industrial Property Rights Holder
  長野清一、荒木敏之、上山盛夫、永井義隆
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-087320
- Filing Date
  2016-04-25
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] 神経難病の診断、治療、ケア．2024
- Author(s)
  長野清一．
- Organizer
  阪神北圏域リハビリテーション支援センター研修会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Presentation] 神経難病の診断、治療、ケア．2024
- Author(s)
  長野清一．
- Organizer
  阪神北圏域リハビリテーション支援センター研修会
- Invited
- Data Source
  KAKENHI-PROJECT-23K18265
[Presentation] 神経難病の診断、治療、ケア．2024
- Author(s)
  長野清一．
- Organizer
  阪神北圏域リハビリテーション支援センター研修会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] 筋萎縮性側索硬化症における生命金属の役割．2023
- Author(s)
  長野清一．
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] A case of familial ALS with a novel mutation in the ANXA11 gene.2023
- Author(s)
  Nagano S, Ogawa K, Sakurai R, Ozono T, Ikenaka K, Mochizuki H.
- Organizer
  Pan-Asian Consortium for Treatment and Research in ALS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Presentation] スフェロイド神経培養におけるCa2+振動に対する塩誘導性キナーゼSIKの影響．2023
- Author(s)
  佐々木勉、神吉秀明、河野友裕、池上剛史、西山久美子、久田素、松村成暢、長野清一、望月秀樹．
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] 神経変性疾患における酸化ストレスの役割．2023
- Author(s)
  長野清一．
- Organizer
  第76回日本酸化ストレス学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K18265
[Presentation] 筋萎縮性側索硬化症（ALS）の病態と治療．2023
- Author(s)
  長野清一．
- Organizer
  豊中市薬剤師会Web研修会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] ALSの遺伝子治療に向けた新たな試み．2023
- Author(s)
  長野清一．
- Organizer
  第11回日本難病医療ネットワーク学会学術集会市民公開講座
- Invited
- Data Source
  KAKENHI-PROJECT-23K18265
[Presentation] ALSの遺伝子治療に向けた新たな試み．2023
- Author(s)
  長野清一．
- Organizer
  第29回日本遺伝子細胞治療学会学術集会市民公開講座
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Presentation] 蛋白質翻訳機能の促進による筋萎縮性側索硬化症の新規治療法の開発2023
- Author(s)
  平木友理，長野清一，佐々木勉，福原充子，津中康央，内山進，望月秀樹．
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K18265
[Presentation] パーキンソン病と腸脳相関に関する最新の話題ー慢性便秘症に対する対処法も含めてー．2023
- Author(s)
  長野清一．
- Organizer
  脳神経内科における便秘治療を考える会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Presentation] 蛋白質翻訳機能の促進による筋萎縮性側索硬化症の新規治療法の開発．2023
- Author(s)
  平木友理、長野清一、佐々木勉、福原充子、津中康央、内山進、望月秀樹．
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] 筋萎縮性側索硬化症における生命金属の役割．2023
- Author(s)
  長野清一．
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Presentation] 筋萎縮性側索硬化症（ALS）の病態と治療．2023
- Author(s)
  長野清一．
- Organizer
  豊中市薬剤師会Web研修会
- Invited
- Data Source
  KAKENHI-PROJECT-23K18265
[Presentation] A case of familial ALS with a novel mutation in the ANXA11 gene.2023
- Author(s)
  Nagano S, Ogawa K, Sakurai R, Ozono T, Ikenaka K, Mochizuki H.
- Organizer
  34th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Presentation] 蛋白質翻訳機能の促進による筋萎縮性側索硬化症の新規治療法の開発．2023
- Author(s)
  平木友理、長野清一、佐々木勉、福原充子、津中康央、内山進、望月秀樹．
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Presentation] 筋萎縮性側索硬化症における生命金属の役割．2023
- Author(s)
  長野清一．
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K18265
[Presentation] A case of familial ALS with a novel mutation in the ANXA11 gene.2023
- Author(s)
  Nagano S, Ogawa K, Sakurai R, Ozono T, Ikenaka K, Mochizuki H.
- Organizer
  Pan-Asian Consortium for Treatment and Research in ALS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18265
[Presentation] ALSの遺伝子治療に向けた新たな試み．2023
- Author(s)
  長野清一．
- Organizer
  第29回日本遺伝子細胞治療学会学術集会市民公開講座
- Invited
- Data Source
  KAKENHI-PROJECT-23K18265
[Presentation] ALSの遺伝子治療に向けた新たな試み．2023
- Author(s)
  長野清一．
- Organizer
  第11回日本難病医療ネットワーク学会学術集会市民公開講座
- Invited
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] パーキンソン病と腸脳相関に関する最新の話題ー慢性便秘症に対する対処法も含めてー．2023
- Author(s)
  長野清一．
- Organizer
  脳神経内科における便秘治療を考える会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] スフェロイド神経培養におけるCa2+振動に対する塩誘導性キナーゼSIKの影響2023
- Author(s)
  佐々木勉，神吉秀明，河野友裕，池上剛史，西山久美子，久田素，松村成暢，長野清一，望月秀樹．
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K18265
[Presentation] A case of familial ALS with a novel mutation in the ANXA11 gene.2023
- Author(s)
  Nagano S, Ogawa K, Sakurai R, Ozono T, Ikenaka K, Mochizuki H.
- Organizer
  34th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18265
[Presentation] Role of axonal mRNA transport and translational regulation in neurodegenerative diseases.2023
- Author(s)
  Nagano S.
- Organizer
  第64回日本神経病理学会総会学術研究会、第66回日本神経化学会大会合同大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Presentation] 筋萎縮性側索硬化症（ALS）の病態と治療．2023
- Author(s)
  長野清一．
- Organizer
  豊中市薬剤師会Web研修会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Presentation] Role of axonal mRNA transport and translational regulation in neurodegenerative diseases.2023
- Author(s)
  Nagano S.
- Organizer
  第64回日本神経病理学会総会学術研究会、第66回日本神経化学会大会合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K18265
[Presentation] ALSの遺伝子治療に向けた新たな試み．2023
- Author(s)
  長野清一．
- Organizer
  第29回日本遺伝子細胞治療学会学術集会市民公開講座
- Invited
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] スフェロイド神経培養におけるCa2+振動に対する塩誘導性キナーゼSIKの影響．2023
- Author(s)
  佐々木勉、神吉秀明、河野友裕、池上剛史、西山久美子、久田素、松村成暢、長野清一、望月秀樹．
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Presentation] ALSの遺伝子治療に向けた新たな試み．2023
- Author(s)
  長野清一．
- Organizer
  第11回日本難病医療ネットワーク学会学術集会市民公開講座
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Presentation] Role of axonal mRNA transport and translational regulation in neurodegenerative diseases.2023
- Author(s)
  Nagano S.
- Organizer
  第64回日本神経病理学会総会学術研究会、第66回日本神経化学会大会合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] 神経変性疾患における酸化ストレスの役割．2023
- Author(s)
  長野清一．
- Organizer
  第76回日本酸化ストレス学会学術集会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04811
[Presentation] パーキンソン病と腸脳相関に関する最新の話題ー慢性便秘症に対する対処法も含めてー．2023
- Author(s)
  長野清一．
- Organizer
  脳神経内科における便秘治療を考える会
- Invited
- Data Source
  KAKENHI-PROJECT-23K18265
[Presentation] A case of familial ALS with a novel mutation in the ANXA11 gene.2023
- Author(s)
  Nagano S, Ogawa K, Sakurai R, Ozono T, Ikenaka K, Mochizuki H.
- Organizer
  34th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] 神経変性疾患における酸化ストレスの役割．2023
- Author(s)
  長野清一．
- Organizer
  第76回日本酸化ストレス学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] A case of familial ALS with a novel mutation in the ANXA11 gene.2023
- Author(s)
  Nagano S, Ogawa K, Sakurai R, Ozono T, Ikenaka K, Mochizuki H.
- Organizer
  Pan-Asian Consortium for Treatment and Research in ALS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] ALSの遺伝子治療2022
- Author(s)
  長野清一、佐々木勉、望月秀樹
- Organizer
  第45回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] 神経変性疾患におけるバイオメタルの役割2022
- Author(s)
  長野清一
- Organizer
  メタルバイオサイエンス研究会2022
- Invited
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] ALSにおける最近の研究動向2022
- Author(s)
  長野清一
- Organizer
  ALS市民公開講座from大阪
- Invited
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] 筋萎縮性側索硬化症（ALS）における局所翻訳機能障害2022
- Author(s)
  長野清一
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] TDP-43 controls ribosomal RNA maturation by regulating the function of ribosomal proteins.2019
- Author(s)
  Nagano S, Jinno J, Mochizuki H, Araki T.
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] Identification of target mRNA transported to axons by TDP-43.2019
- Author(s)
  Nagano S, Ueyama M, Nagai Y, Mochizuki H, Araki T.
- Organizer
  第15回成体脳ニューロン新生懇談会
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] TDP-43により軸索輸送される標的mRNAの探索．2019
- Author(s)
  長野清一．
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] 鉄と神経変性疾患―筋萎縮性側索硬化症（ALS）を中心に―．2019
- Author(s)
  長野清一．
- Organizer
  第43回日本鉄バイオサイエンス学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] リボソームの機能促進による筋萎縮性側索硬化症の新規治療戦略.2019
- Author(s)
  長野清一、望月秀樹．
- Organizer
  大阪大学先導的学際研究機構シンポジウム「未来医療を推進する革新的技術のフロンティア」
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] Regulation of TDP-43-mediated neurotoxicity by ribosome-related factors.2018
- Author(s)
  Nagano S, Mochizuki H, Araki T.
- Organizer
  5th RNA Metabolism in Neurological Disease Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] ALSにおけるHGF治験．2018
- Author(s)
  長野清一、割田　仁、望月秀樹、青木正志．
- Organizer
  第36回日本神経治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] Gene therapy for ALS.2018
- Author(s)
  Nagano S.
- Organizer
  第24回日本遺伝子細胞治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] Identification of target mRNA transported to axons by TDP-43.2018
- Author(s)
  Nagano S, Ueyama M, Nagai Y, Mochizuki H, Araki T.
- Organizer
  143rd Annual Meeting of the American Neurological Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] Regulation of TDP-43-mediated neurotoxicity by ribosome-related factors.2018
- Author(s)
  Nagano S, Mochizuki H, Araki T.
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] 筋萎縮性側索硬化症（ALS）の病態解明と治療薬開発に向けて-Review　メタルバイオの視点から－2017
- Author(s)
  長野清一
- Organizer
  メタルバイオサイエンス研究会2017
- Invited
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] Identification of target mRNA transported to axons by TDP-432017
- Author(s)
  S. Nagano, M. Ueyama, Y. Nagai, H. Mochizuki, T. Araki
- Organizer
  28th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] Identification of target mRNA transported to axons by TDP-432017
- Author(s)
  S. Nagano, M. Ueyama, Y. Nagai, H. Mochizuki, T. Araki
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] リボソーム関連因子によるTDP-43神経毒性の制御2017
- Author(s)
  長野清一、望月秀樹、荒木敏之
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] Neurotoxicity of TDP-43 is linked to axonal dysfunction of ribosomal proteins2016
- Author(s)
  Nagano S, Ueyama M, Wada K, Nagai Y, Araki T.
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] Neuronal toxicity of TDP-43 is associated with the dysfunction of ribosomal proteins in axons2016
- Author(s)
  Nagano S, Ueyama M, Wada K, Nagai Y, Saito Y, Araki T.
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター、神戸ポートピアホテル
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] Identification of target mRNA transported to axons by TDP-432016
- Author(s)
  Nagano S, Ueyama M, Wada K, Nagai Y, Araki T.
- Organizer
  11th Brain Research Conference
- Place of Presentation
  Paradise Point, San Diego, USA
- Year and Date
  2016-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] TDP-43によるリボソーム蛋白質mRNAの神経軸索への輸送2016
- Author(s)
  長野清一，荒木敏之．
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16K09690
[Presentation] TDP-43 transports mRNA of ribosomal proteins2015
- Author(s)
  Nagano S, Hirokawa S, Nishizawa M, Sakimura K, Onodera O, Araki T.
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟コンベンションセンター、新潟
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-25461302
[Presentation] Role of cysteine residue of mutant SOD1 in the pathogenesis of ALS2015
- Author(s)
  Nagano S, Takahashi Y, Yamamoto K, Masutani H, Fujiwara N, Urushitani M, Araki T.
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場・神戸国際展示場、神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25461302
[Presentation] TDP-43 transports mRNA of ribosomal proteins2015
- Author(s)
  Nagano S, Hirokawa S, Nishizawa M, Sakimura K, Onodera O, Araki T.
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド、神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25461302
[Presentation] 銅を介した変異SOD1の運動神経毒性はシステイン残基に依存する2015
- Author(s)
  長野清一、高橋陽子、山本和弘、増谷　弘、藤原範子、漆谷　真、荒木敏之．
- Organizer
  メタルバイオサイエンス研究会2015
- Place of Presentation
  名古屋国際センター、名古屋
- Year and Date
  2015-08-27
- Invited
- Data Source
  KAKENHI-PROJECT-25461302
[Presentation] TDP-43による翻訳関連遺伝子mRNAの神経突起への輸送2013
- Author(s)
  長野清一、荒木敏之
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム、東京
- Data Source
  KAKENHI-PROJECT-25461302
[Presentation] Identification of mRNA targeted to axons by TDP-432013
- Author(s)
  S. Nagano
- Organizer
  新潟脳神経研究会特別例会
- Place of Presentation
  新潟大学脳研究所、新潟
- Invited
- Data Source
  KAKENHI-PROJECT-25461302
[Presentation] Identification of mRNA transported to axons by TDP-432013
- Author(s)
  S. Nagano, T. Araki
- Organizer
  第4回新潟大学脳研究所共同研究拠点国際シンポジウム
- Place of Presentation
  新潟大学脳研究所、新潟
- Data Source
  KAKENHI-PROJECT-25461302
[Presentation] TDP-43による翻訳関連遺伝子mRNAの神経突起への輸送2013
- Author(s)
  長野清一、荒木敏之
- Organizer
  第32回日本認知症学会学術集会
- Place of Presentation
  キッセイ文化ホール、松本
- Data Source
  KAKENHI-PROJECT-25461302
[Presentation] TDP-43により神経突起へ輸送される標的mRNAの同定2012
- Author(s)
  長野清一
- Organizer
  日本分子生物学会年会
- Place of Presentation
  福岡、福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-22590932
[Presentation] TDP-43により神経突起へ輸送される標的mRNAの探索2012
- Author(s)
  長野清一
- Organizer
  日本神経学会学術大会
- Place of Presentation
  東京、東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-22590932
[Presentation] TDP-43により神経突起へ輸送される標的mRNAの同定2012
- Author(s)
  長野清一
- Organizer
  日本分子生物学会年会
- Place of Presentation
  福岡, 福岡国際会議場・マリンメッセ福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-22590932
[Presentation] TDP-43により神経突起へ輸送される標的mRNAの探索2012
- Author(s)
  長野清一
- Organizer
  日本神経学会学術大会
- Place of Presentation
  東京, 東京国際フォーラム
- Year and Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-22590932
[Presentation] 筋萎縮性側索硬化症における銅の役割2012
- Author(s)
  長野清一
- Organizer
  日本微量元素学会学術集会
- Place of Presentation
  東京, シェーンバッハ・サボー
- Year and Date
  2012-07-06
- Data Source
  KAKENHI-PROJECT-22590932
[Presentation] 筋萎縮性側索硬化症における銅の役割2012
- Author(s)
  長野清一
- Organizer
  日本微量元素学会学術集会
- Place of Presentation
  東京、シェーンバッハ・サボー
- Invited
- Data Source
  KAKENHI-PROJECT-22590932
[Presentation] メタロチオネイン、亜鉛、銅と神経変性疾患2011
- Author(s)
  長野清一
- Organizer
  メタロチオネインおよびメタルバイオサイエンス研究会
- Place of Presentation
  名古屋, 中電ホール
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-22590932
[Presentation] FALS患者検体から示唆される変異型SOD1毒性:シナプス構造緻密化の可能性2011
- Author(s)
  長野清一
- Organizer
  日本人類遺伝学会
- Place of Presentation
  千葉、幕張メッセ
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22590932
[Presentation] FALS患者検体から示唆される変異型SOD1毒性:シナプス構造緻密化の可能性2011
- Author(s)
  長野清一
- Organizer
  日本人類遺伝学会
- Place of Presentation
  千葉, 幕張メッセ
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22590932
[Presentation] メタロチオネイン、亜鉛、銅と神経変性疾患2011
- Author(s)
  長野清一
- Organizer
  メタロチオネインおよびメタルバイオサイエンス研究会
- Place of Presentation
  名古屋、中電ホール(招待講演)
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-22590932
[Presentation] なぜ銅キレート剤はALSモデルマウスに効果があるのか?-翻訳後修飾とモノマー化-2010
- Author(s)
  長野清一
- Organizer
  日本神経学会総会
- Place of Presentation
  東京, 東京国際フォーラム.
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-22590932
[Presentation] なぜ銅キレート剤はALSモデルマウスに効果があるのか?-翻訳後修飾とモノマー化-2010
- Author(s)
  長野清一、岸上仁、佐古田三郎
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京国際フォーラム(東京都)
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-22590932
[Presentation] 変異型SOD1の運動神経毒性におけるシステイン残基の役割
- Author(s)
  長野清一、山本和弘、漆谷　真、荒木敏之
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場・福岡サンパレス・福岡国際センター、福岡
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461302
[Presentation] Identification of target mRNA transported to axons by TDP-43
- Author(s)
  Seiichi Nagano, Sachiko Hirokawa, Masatoyo Nishizawa, Kenji Sakimura, Osamu Onodera, Toshiyuki Araki
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25461302
[Presentation] Role of cysteine residue of mutant SOD1 in the pathogenesis of ALS
- Author(s)
  Nagano S, Yamamoto K, Urushitani M, Fujiwara N, Araki T
- Organizer
  25th International Symposium on ALS/MND
- Place of Presentation
  Square Brussels Meeting Centre, Brussels, Belgium
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-25461302
[Presentation] Identification of target mRNA transported to axons by TDP-43
- Author(s)
  Seiichi Nagano, Toshiyuki Araki
- Organizer
  国立精神・神経医療研究センター―マックスプランク合同シンポジウム
- Place of Presentation
  ザ・プリンス箱根、箱根
- Year and Date
  2014-11-05 – 2014-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-25461302

1. NAGAI Yoshitaka (60335354)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
2. SUMI Hisae (30403059)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SATO Naoyuki (70372612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 竹屋泰 (70590339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 池中建介 (70774058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 小河浩太郎 (80870500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 関壮樹 (60755081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田中晋 (00367541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山本徹 (20707335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 内橋俊大 (60757839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 平岡慎一郎 (70615616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 内山進 (90335381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKEYA Miyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MUKOUZONO Masahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAKAHASHI Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. SASAKI Tsutomu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. MATSUMURA Shigenobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 山口圭一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 望月秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 角田渓太

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 別宮豪一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 増谷弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 熱田直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
24. 祖父江元

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
25. 馬場孝輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 道勇学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 津田浩史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGANO SEIICHI 長野 清一

NAGANO Seiichi 長野 清一

長野 清一 ナガノ セイイチ

Research Projects

Research Products

Co-Researchers

患者組織由来RNA-seqの統合的解析によるALS病態関連因子の同定Principal Investigator

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Development of a Novel ALS Therapeutic Strategy Targeting Primary Sensory Neurons

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細胞種特異的スプライシング変化を介したALS発症機序の解明Principal Investigator

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神経細胞内鉄代謝障害に基づく筋萎縮性側索硬化症の病態解明Principal Investigator

Principal Investigator

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Elucidation of the pathogenesis and development of the treatment strategy of ALS/FTLD focusing on the local translation in neuronal axonsPrincipal Investigator

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Investigation of ALS/FTLD pathogenesis based on translational deterioration due to ribosome dysfunction in axonsPrincipal Investigator

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Investigation of key molecules involved in bidirectional interactions between diabetes and dementia

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Pathogenesis of TDP-43 proteinopathy based on the transport defect of target mRNAPrincipal Investigator

Principal Investigator

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Elucidation of the neuronal toxicity mechanism by TDP-43 based on dysfunction of the nucleocytoplasmic shuttlingPrincipal Investigator

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家族性筋萎縮性側索硬化症における変異SOD1特異的銅親和性の解析Principal Investigator

Principal Investigator

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家族性筋萎縮性側索硬化症における変異SOD1特異的銅親和性の解析Principal Investigator

Principal Investigator

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[Book] 今日の治療指針2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Annual Review 神経 20182018

Author(s)

NAGANO SEIICHI 長野清一

NAGANO Seiichi 長野清一

長野清一ナガノセイイチ