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Sekine Hideharu  関根 英治

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SEKINE Hideharu  関根 英治

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Researcher Number 40363759
Affiliation (Current) 2022: 福島県立医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2017 – 2022: 福島県立医科大学, 医学部, 教授
2012 – 2015: 福島県立医科大学, 医学部, 教授
2009 – 2011: Fukushima Medical University, 医学部, 講師
Review Section/Research Field
Principal Investigator
膠原病・アレルギー・感染症内科学 / Basic Section 49070:Immunology-related / Collagenous pathology/Allergology
Except Principal Investigator
Basic Section 56030:Urology-related / Ophthalmology / Basic Section 56060:Ophthalmology-related / Basic Section 49070:Immunology-related
Keywords
Principal Investigator
補体 / レクチン経路 / 第二経路 / 全身性エリテマトーデス / ループス腎炎 / インターフェロン調節因子4 / CD4陽性T細胞 / Th1 / Th17 / CD4性T細胞 … More / IRF4 / IRF1 / 自己免疫 / 肉芽腫 / 国際情報交換 / アメリカ / IRF-4 / IRF-1 / MASP-1/3 / MAp44 / 補体因子 / MASP-3 / 認識分子 / 補体レクチン経路 / レクチン経路の糖鎖認識分子 / 補体活性化 / セリンプロテアーゼ / 補体制御因子 … More
Except Principal Investigator
補体 / 加齢黄斑変性 / 前立腺肥大症 / 滲出型加齢黄斑変性 / アナフィラトキシン / サイトカイン / VEGF / MCP-1 / Pachychoroid / 特発性黄斑上膜 / 特発性黄斑円孔 / 自己免疫疾患 / 細菌 / 微生物 / 細胞増殖 / 自己免疫反応 / オートファジー / レクチン経路 / 古典経路 / 過活動膀胱 / 低活動膀胱 / 自己免疫応答 / 神経ネットワーク / MASP-3 / 補体第二経路 / 共免疫沈降 / ノックアウトマウス Less
  • Research Projects

    (10 results)
  • Research Products

    (80 results)
  • Co-Researchers

    (34 People)
  •  Disease-specific comprehensive pathogenesis of male lower urinary tract dysfunction and development of innovative therapies

    • Principal Investigator
      小島 祥敬
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Fukushima Medical University
  •  Serpinによる補体第二経路D因子の新規な制御機構Principal Investigator

    • Principal Investigator
      関根 英治
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Fukushima Medical University
  •  Identification of the protease in blood that activates complement factor MASP-3

    • Principal Investigator
      町田 豪
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Fukushima Medical University
  •  滲出型加齢黄斑変性の病態形成に補体レクチン経路が関与する

    • Principal Investigator
      大森 智子
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Fukushima Medical University
  •  Elucidation of the activation mechanism of the complement factor MASP-3 of the alternative complement pathwayPrincipal Investigator

    • Principal Investigator
      Sekine Hideharu
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Fukushima Medical University
  •  Mechanisms of Inflammasome Regulation by Autoimmune Responses and Microbial Infection in Benign Prostatic Hyperplasia

    • Principal Investigator
      Kojima Yoshiyuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Fukushima Medical University
  •  The mechanism of age-related macular degeneration by measuring intraocular complement factors and related proteins

    • Principal Investigator
      Tetsuju Sekiryu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Fukushima Medical University
  •  Development of complement component MASP-1/3 inhibitors for treatment of lupus animal models.Principal Investigator

    • Principal Investigator
      SEKINE Hideharu
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Fukushima Medical University
  •  IRF-4 is associated with the development of granulomas in autoimmune diseasePrincipal Investigator

    • Principal Investigator
      SEKINE Hideharu
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Fukushima Medical University
  •  CD4 positive T cells directly associate with development of lupus nephritis.Principal Investigator

    • Principal Investigator
      SEKINE Hideharu
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Fukushima Medical University

All 2022 2021 2020 2019 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

  • [Book] 免疫複合体の可溶化とクリアランス,In補体への招待2011

    • Author(s)
      関根英治(大井洋之,木下タロウ,松下操編)
    • Publisher
      メジカルビュー社
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Book] 補体への招待2011

    • Author(s)
      関根英治
    • Publisher
      メジカルビュー社
    • Data Source
      KAKENHI-PROJECT-21890204
  • [Book] 補体の検査法と意義,In臨床検査増刊号・ここまでわかった自己免疫疾患2011

    • Author(s)
      関根英治(宮坂信之)
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] ARMS2 and CFH polymorphism and intraocular complement activation in neovascular age-related macular degeneration2022

    • Author(s)
      Yutaka Kato, Yasuharu Oguchi, Tomoko Omori, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Yumi Ishida, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu
    • Journal Title

      Ophthalmology Science

      Volume: In press

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07083
  • [Journal Article] Polymorphisms of the FCN2 Gene 3'UTR Region and Their Clinical Associations in Preterm Newborns2021

    • Author(s)
      Anna S Swierzko, Dariusz Jarych, Gabriela Gajek, Karolina Chojnacka, Paulina Kobiela, Maja Kufelnicka-Babout, Mateusz Michalski, Katarzyna Sobczuk, Agnieszka Szala-Pozdziej, Misao Matsushita, Jan Mazela, Iwona Domzalska-Popadiuk, David C Kilpatrick, Jaroslaw Kalinka, Hideharu Sekine, Maciej Cedzynski
    • Journal Title

      Front Immunol

      Volume: 12

    • DOI

      10.3389/fimmu.2021.741140

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07610
  • [Journal Article] Changes in complement activation products after anti‐VEGF injection for choroidal neovascularization in age‐related macular degeneration and pachychoroid disease2021

    • Author(s)
      Tanaka Keiichiro、Oguchi Yasuharu、Omori Tomoko、Ishida Yumi、Shintake Hiroaki、Tomita Ryutaro、Kasai Akihito、Ogasawara Masashi、Sugano Yukinori、Itagaki Kanako、Ojima Akira、Machida Takeshi、Sekine Hideharu、Sekiryu Tetsuju
    • Journal Title

      Sci Rep

      Volume: 11 Pages: 8464-8464

    • DOI

      10.1038/s41598-021-87340-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K18882, KAKENHI-PROJECT-19K07610, KAKENHI-PROJECT-20K09776, KAKENHI-PROJECT-21K07083
  • [Journal Article] Association between serum ficolin-1 level and disease progression in primary biliary cholangitis2020

    • Author(s)
      Hayashi Manabu、Abe Kazumichi、Fujita Masashi、Takahashi Atsushi、Sekine Hideharu、Ohira Hiromasa
    • Journal Title

      PLOS ONE

      Volume: 15

    • DOI

      10.1371/journal.pone.0238300

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07610
  • [Journal Article] 感染症と補体・凝固線溶系2020

    • Author(s)
      関根英治
    • Journal Title

      Thrombosis Medicine

      Volume: 10 Pages: 274-280

    • Data Source
      KAKENHI-PROJECT-19K07610
  • [Journal Article] Anaphylatoxin concentration in aqueous and vitreous humor in the eyes with vitreoretinal interface abnormalities2020

    • Author(s)
      Yasuharu Oguchi , Tetsuju Sekiryu , Tomoko Omori , Yutaka Kato , Masashi Ogasawara , Yukinori Sugano , Kanako Itagaki , Akira Ojima , Takeshi Machida , Hideharu Sekine
    • Journal Title

      Experimental Eye Research

      Volume: 195 Pages: 108025-108025

    • DOI

      10.1016/j.exer.2020.108025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K11427, KAKENHI-PROJECT-17K16975, KAKENHI-PROJECT-19K07610, KAKENHI-PROJECT-18K08392
  • [Journal Article] Complement Activation Products and Cytokines in Pachychoroid Neovasculopathy and Neovascular Age-Related Macular Degeneration2020

    • Author(s)
      Kato Yutaka、Oguchi Yasuharu、Omori Tomoko、Shintake Hiroaki、Tomita Ryutaro、Kasai Akihito、Ogasawara Masashi、Sugano Yukinori、Itagaki Kanako、Ojima Akira、Machida Takeshi、Sekine Hideharu、Sekiryu Tetsuju
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 61 Pages: 39-39

    • DOI

      10.1167/iovs.61.13.39

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07610, KAKENHI-PROJECT-20K09776, KAKENHI-PROJECT-19K18882
  • [Journal Article] A novel complement inhibitor sMAP‐FH targeting both the lectin and alternative complement pathways2020

    • Author(s)
      Takasumi M, Omori T, Machida T, Ishida Y, Hayashi M, Suzuki T, Homma Y, Endo Y, Takahashi M, Ohira H, Fujita T, Sekine H
    • Journal Title

      The FASEB Journal

      Volume: 34 Pages: 6598-6612

    • DOI

      10.1096/fj.201902475r

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K16975, KAKENHI-PROJECT-19K07610, KAKENHI-PROJECT-18K08392
  • [Journal Article] Complement Activation by Autoantigen Recognition in the Growth Process of Benign Prostatic Hyperplasia2019

    • Author(s)
      Hata Junya、Machida Takeshi、Matsuoka Kanako、Hoshi Seiji、Akaihata Hidenori、Hiraki Hiroyuki、Suzuki Toshiyuki、Ogawa Soichiro、Kataoka Masao、Haga Nobuhiro、Ishibashi Kei、Homma Yoshimi、Sekine Hideharu、Kojima Yoshiyuki
    • Journal Title

      SOCIENTIFIC REPORTS

      Volume: 9 Pages: 00-00

    • DOI

      10.1038/s41598-019-57001-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07610, KAKENHI-PROJECT-19K09733, KAKENHI-PROJECT-17K16802
  • [Journal Article] Response to Comment on “Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway”2019

    • Author(s)
      Takeshi Machida, Manabu Hayashi, Teizo Fujita, and Hideharu Sekine
    • Journal Title

      The Journal of Immunology

      Volume: 203 Pages: 3091-3092

    • DOI

      10.4049/jimmunol.1901087

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08392, KAKENHI-PROJECT-19K07610
  • [Journal Article] Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway2019

    • Author(s)
      Manabu Hayashi, Takeshi Machida, Yumi Ishida, Yusuke Ogata, Tomoko Omori, Mika Takasumi, Yuichi Endo, Toshiyuki Suzuki, Masayuki Sekimata, Yoshimi Homma, Masahito Ikawa, Hiromasa Ohira, Teizo Fujita, and Hideharu Sekine
    • Journal Title

      the J Immunol

      Volume: 203 Pages: 1411-1416

    • DOI

      10.4049/jimmunol.1900605

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08392, KAKENHI-PROJECT-18K08895, KAKENHI-PROJECT-19K07610, KAKENHI-PROJECT-18K15789, KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-17K16975
  • [Journal Article] Granular C3 dermatosis.2016

    • Author(s)
      Hashimoto T, Tsuruta D, Yasukochi A, Imanishi H, Sekine H, Fujita T, Wanibuchi H, Gi M, Kárpáti S, Sitaru C, Zone JJ, Endo D, Abe S, Nishino T, Koji T, Ishii N.
    • Journal Title

      Acta Derm.-Venereol.

      Volume: 00 Pages: 0-0

    • DOI

      10.2340/00015555-2379

    • NAID

      120006987674

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670478, KAKENHI-PROJECT-26861762, KAKENHI-PROJECT-16H05813, KAKENHI-PROJECT-26340042, KAKENHI-PROJECT-16K10180, KAKENHI-PROJECT-16K18979, KAKENHI-PROJECT-16K20585
  • [Journal Article] 膠原病への補体の関与と抗補体療法の可能性2016

    • Author(s)
      関根英治
    • Journal Title

      医学のあゆみ

      Volume: 257 Pages: 00-00

    • Data Source
      KAKENHI-PROJECT-26670478
  • [Journal Article] 補体異常値を示す疾患とそのメカニズム2015

    • Author(s)
      関根英治、大森智子、町田 豪
    • Journal Title

      補体

      Volume: 52 Pages: 14-26

    • NAID

      40020953030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Journal Article] Autoantibody-secreting marginal zone B cells develop significantly in lupus-prone MRL/lpr mice but not associated with expression of IFN-γ-receptor-1 on their surfaces.2014

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Tomoko Omori, and Hideharu Sekine
    • Journal Title

      Proceedings of the Japanese Society for Immunology

      Volume: 43 Pages: 189-189

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Journal Article] A dual role for IFN-γ in development of peripheral B cells in lupus-prone MRL/lpr mice.2014

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Gary S. Gilkeson, and Hideharu Sekine
    • Journal Title

      Arthritis Rheum

      Volume: 66

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Journal Article] Lack of IRF-1 accelerates development of tubulointerstitial nephritis and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice.2013

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Eiji Suzuki, Xian Zhang, Christopher M. Reilly, Gary S. Gilkeson, and Hideharu Sekine
    • Journal Title

      Front Immunol

      Volume: N/A

    • DOI

      10.3389/conf.fimmu.2013.02.00862

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] 補体の異常値と疾患2013

    • Author(s)
      関根英治,町田豪,坂本夏美,高橋実
    • Journal Title

      福島医学雑誌

      Volume: 63 Pages: 93-107

    • NAID

      40019766693

    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] Role of complement in a murine model of peanut-induced anaphylaxis2013

    • Author(s)
      Kodama T, Sekine H, Takahashi M, Iwaki D, Machida T, Kanno K, Ishida Y, Endo Y, and Fujita T
    • Journal Title

      Immunobiology

      Volume: 218 Pages: 844-850

    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] Comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function".2013

    • Author(s)
      Takahashi M, Sekine H, Endo Y, Fujita T.
    • Journal Title

      J Immunol

      Volume: 190 Pages: 2477-2477

    • DOI

      10.4049/jimmunol.1390002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590342, KAKENHI-PROJECT-23591442, KAKENHI-PROJECT-25460596
  • [Journal Article] Involvement of both the lectin and classical pathways in peanut-induced complement activation and anaphylaxis.2013

    • Author(s)
      Kodama T1, Sekine H, Takahashi M, Iwaki D, Machida T, Kanno K, Ishida Y, Endo Y, Fujita T.
    • Journal Title

      Immunobiology

      Volume: 218 Pages: 844-850

    • DOI

      10.1016/j.imbio.2012.10.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590342, KAKENHI-PROJECT-23591442, KAKENHI-PROJECT-23790542
  • [Journal Article] The role of MASP-1/3 in complement activation.2013

    • Author(s)
      Hideharu Sekine, Minoru Takahashi, Daisuke Iwaki, and Teizo Fujita
    • Journal Title

      Adv Exp Med Biol.

      Volume: 735 Pages: 41-53

    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-γ levels and increased expression of IFN-γ-receptor-1 on B cells.2013

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Kiri Honma, Toshifumi Matsuyama, Katsuyuki Yui, and Hideharu Sekine
    • Journal Title

      Front Immunol

      Volume: N/A

    • DOI

      10.3389/conf.fimmu.2013.02.00861

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] The Role of MASP-1/3 in Complement Activation.2013

    • Author(s)
      Sekine H, Takahashi M, Iwaki D, Fujita T.
    • Journal Title

      Adv Exp Med Biol

      Volume: 735 Pages: 41-53

    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] The role of MASP-1/3 in complement activation2013

    • Author(s)
      Sekine H, Takahashi M, Iwaki D, and Fujita T
    • Journal Title

      Adv Exp Med Biol

      Volume: 735 Pages: 41-53

    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] Comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function"2013

    • Author(s)
      Takahashi M, Sekine H, Endo Y, and Fujita T
    • Journal Title

      J Immunol

      Volume: 190 Pages: 2477-2477

    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] 補体の異常値と疾患.2013

    • Author(s)
      関根英治, 町田豪, 坂本夏美, 高橋実
    • Journal Title

      福島医学雑誌

      Volume: 63 Pages: 93-107

    • NAID

      40019766693

    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] Association of the toll-like receptor 9 gene polymorphisms with Behcet's disease in a Japanese population.2012

    • Author(s)
      Sakamoto N, Sekine H, Kobayashi H, Sato Y, Ohira H.
    • Journal Title

      Fukushima J Med Sci

      Volume: 58 Pages: 127-135

    • NAID

      130002566785

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] Association of the toll-like receptor 9 gene polymorphisms with Behcet's disease in a Japanese population2012

    • Author(s)
      Sakamoto N, Sekine H, Kobayashi H, Sato Y, Ohira H
    • Journal Title

      Fukushima J Med Sci

      Volume: 58 Pages: 127-135

    • NAID

      130002566785

    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] The dual role of complement in the progression of renal disease in NZB/W F1 mice and alternative pathway inhibition2011

    • Author(s)
      Sekine H, Ruiz P, Gilkeson GS, and Tomlinson S
    • Journal Title

      Mol Immunol

      Volume: 49 Pages: 317-323

    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice2011

    • Author(s)
      Sekine H, Kinser TT, Qiao F, Martinez E, Paulling E, Ruiz P, Gilkeson GS, and Tomlinson S
    • Journal Title

      Arthritis Rheum

      Volume: 63 Pages: 1076-1085

    • Data Source
      KAKENHI-PROJECT-23591442
  • [Journal Article] Comment on "Reassessment of the role of mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching".2009

    • Author(s)
      Sekine H, Ferreira RC, Pan-Hammarstrom Q, Hammarstrom L, Gilkeson GS, Behrens TW.
    • Journal Title

      J Immunol 182

      Pages: 496-497

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21890204
  • [Presentation] The significance of complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway in the long-term retention of MASP-3 in the circulation2021

    • Author(s)
      Takeshi Machida, Kohei Kusakari, Yumi Ishida, Tomoko Omori, Toshiyuki Suzuki, Masayuki Sekimata, Teizo Fujita, and Hideharu Sekine
    • Organizer
      28th International Complement Virtual Workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07610
  • [Presentation] The significance of complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway in the long-term retention of MASP-3 in the circulation2021

    • Author(s)
      Takeshi Machida, Kohei Kusakari, Yumi Ishida, Tomoko Omori, Toshiyuki Suzuki, Masayuki Sekimata, Teizo Fujita, Hideharu Sekine
    • Organizer
      2021 Virtual Workshop of the International ComplementSociety
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09776
  • [Presentation] MASP-3 の活性化におけるレクチン経路の認識分子の役割2021

    • Author(s)
      草刈浩平、石田由美、大森智子、鈴木俊幸、関亦正幸、町田豪、関根英治
    • Organizer
      第57回日本補体学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07083
  • [Presentation] MASP-3の活性化におけるレクチン経路の認識分子の役割2021

    • Author(s)
      草刈浩平、石田由美、大森智子、鈴木俊幸、関亦正幸、町田豪、関根英治
    • Organizer
      第57回日本補体学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K09776
  • [Presentation] MASP-3の活性化におけるレクチン経路の認識分子の役割2021

    • Author(s)
      草刈 浩平、石田 由美、大森 智子、鈴木 俊幸、関亦 正幸、町田 豪、関根 英治
    • Organizer
      日本補体学会
    • Data Source
      KAKENHI-PROJECT-19K07610
  • [Presentation] The significance of complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway in the long-term retention of MASP-3 in the circulation2021

    • Author(s)
      Takeshi Machida, Kohei Kusakari, Yumi Ishida, Tomoko Omori, Toshiyuki Suzuki, Masayuki Sekimata, Teizo Fujita, and Hideharu Sekine
    • Organizer
      28th International Complement Virtual Workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07083
  • [Presentation] A FUSION PROTEIN OF SMAP AND FACTOR H INHIBITS BOTH THE LECTIN AND ALTERNATIVE COMPLEMENT PATHWAYS IN VIVO2019

    • Author(s)
      Hideharu Sekine, Mika Takasumi, Tomoko Omori, Takeshi Machida, Yumi Ishida, and Teizo Fujita
    • Organizer
      The 17th European Meeting on Complement in Human Disease (EMCHD 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07610
  • [Presentation] Current topics in Immunology2016

    • Author(s)
      Hideharu Sekine
    • Organizer
      Whuhan University International Program
    • Place of Presentation
      中華人民共和国武漢市
    • Year and Date
      2016-02-23
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Presentation] T細胞の抗原認識における免疫チェックポイント分子の役割について2016

    • Author(s)
      関根英治
    • Organizer
      Academy of Clinical Immunology, one step further
    • Place of Presentation
      福島県福島市
    • Year and Date
      2016-03-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Presentation] 補体制御因子を応用した抗補体薬の開発と今後の展開2016

    • Author(s)
      関根英治
    • Organizer
      第27回免疫細胞療法研究会
    • Place of Presentation
      福島県福島市
    • Year and Date
      2016-05-09
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Presentation] Upregulation of Complement C3 and Alpha-2-Macroglobulin in Cerebrospinal Fluid of Neuropsychiatric Systemic Lupus Erythematosus2015

    • Author(s)
      Tomoyuki Asano, Shuzo Sato, Hiroko Kobayashi, Yoshinobu Kariya, Hiromi Ito, Kyoka Hoshi, Akioh Yoshihara, Yoshikazu Ugawa, Minoru Takahashi, Hideharu Sekine, Shunsei Hirohata, Hiroshi Watanabe, Hiromasa Ohira and Yasuhiro Hashimoto
    • Organizer
      2015-Annual Scientific Meeting of the American College of Rheumatology
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2015-11-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Presentation] 補体因子MASP-1/3欠損のMRL/lprマウスでは補体第二経路の活性化が抑制され、糸球体腎炎が改善される2015

    • Author(s)
      坂本夏美、町田豪、高橋実、関根英治
    • Organizer
      Rheumatology Conference 2015
    • Place of Presentation
      東京都中央区
    • Year and Date
      2015-06-06
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Presentation] 臨床医学と免疫学の接点:最近の免疫学の話題2015

    • Author(s)
      関根英治
    • Organizer
      福島県立医科大学光が丘協議会ステップアップセミナー
    • Place of Presentation
      福島県国見町
    • Year and Date
      2015-11-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Presentation] マウス型リコンビナントタンパクrmMAp44-PA, rmMAp44-Igの作製と補体レクチン経路の阻害作用2015

    • Author(s)
      高住美佳、高橋実、大森智子、町田豪、坂本夏美、石田由美、関根英治
    • Organizer
      日本補体学会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2015-08-21
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Presentation] 炎症性疾患に自然免疫はどう関与すのか~補体の役割を中心に~2014

    • Author(s)
      関根英治
    • Organizer
      第23回日本集中治療医学会東北地方会
    • Place of Presentation
      山形県山形市
    • Year and Date
      2014-06-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Presentation] 免疫学と臨床医学の接点 ~自然免疫(補体)を中心に~2014

    • Author(s)
      関根英治
    • Organizer
      福島県立医科大学光が丘協議会ステップアップセミナー
    • Place of Presentation
      福島県国見町
    • Year and Date
      2014-11-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Presentation] Masp-1/3 deficient MRL/lpr mice lack the alternative complement pathway activation and are protected from development of lupus-like glomerulonephritis.2013

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Teizo Fujita, Minoru Takahashi, and Hideharu Sekine
    • Organizer
      2013-Annual Scientific Meeting of the American College of Rheumatology (ACR)
    • Place of Presentation
      San Diego, CA, USA
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] Lack of IRF-1 accelerates development of tubulointerstitial nephritis and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice.2013

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Eiji Suzuki, Xiang Zhang, Christopher Reilly, Gary Gilkeson, and Hideharu Sekine
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] Aged IRF-4- deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-γlevels and increased expression of IFN-γ-receptor-1 on B cells2013

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Kiri Honma, Toshifumi Matsuyama, Katsuyuki Yui, and Hideharu Sekine
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2013-08-27
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] Lack of IRF-1 accelerates development of tubulointerstitial nephritis and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice2013

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Eiji Suzuki, Xian Zhang, Christopher M. Reilly, Gary S. Gilkeson, and Hideharu Sekine
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2013-08-27
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] Lupus-prone MRL/lpr mice express IFN-γ-receptor-1 abundantly on peripheral B cells that is responsible for peripheral B-cell survival/maintenance and autoantibody production.2013

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Kiri Honma, Toshifumi Matsuyama, Katsuyuki Yui, and Hideharu Sekine
    • Organizer
      5th International Conference on “B cells and Autoimmunity”
    • Place of Presentation
      Como Lake, Italy
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-γ levels and increased expression of IFN-γ-receptor-1 on B cells.2013

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Kiri Honma, Toshifumi Matsuyama, Katsuyuki Yui, and Hideharu Sekine
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] IFN-γ-receptor-1 is expressed abundantly on splenic B cells of MRL/lpr mice and is involved in peripheral B-cell survival/maintenance and autoantibody production.2013

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Kiri Honma, Toshifumi Matsuyama, Katsuyuki Yui, and Hideharu Sekine
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉, 幕張メッセ
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] Lack of interferon regulatory factor-1 accelerates development of interstitial nephritis, renal vasculitis, and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice2012

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Eiji Suzuki, Xian Zhang, Christopher Reilly, Gary S. Gilkeson, and Hideharu Sekine
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-12-07
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] IRF-1 deficient lupus-prone MRL/lpr mice show reduced glomerulonephritis but develop severe interstitial nephritis, renal vasculitis and pulmonary granulomas with propensity for Th2 polarity2012

    • Author(s)
      Hideharu Sekine, Takeshi Machida, Natsumi Sakamoto, Eiji Suzuki, Xian Zhang, Christopher Reilly, and Gary S. Gilkeson
    • Organizer
      The 76th Annual Meeting of the American College of Rheumatology
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2012-11-12
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] Lack of interferon regulatory factor-1 accelerates development of interstitial nephritis, renal vasculitis, and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice.2012

    • Author(s)
      Machida T, Sakamoto N, Suzuki E, Zhang X, Reilly C, Gilkeson GS, Sekine H
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] IRF-1 Deficient Lupus-Prone MRL/Lpr Mice Show Reduced Glomerulonephritis but Develop Severe Interstitial Nephritis, Renal Vasculitis and Pulmonary Granulomas with Propensity for Th2 Polarity.2012

    • Author(s)
      Sekine H, Machida T, Sakamoto N, Suzuki E, Zhang X, Reilly C, Gilkeson GS
    • Organizer
      American College of Rheumatology (ACR) Scientific Meeting, 2012
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] Role of complement in a murine model of peanut-induced anaphylaxis.2012

    • Author(s)
      Kodama T, Endo Y, Takahashi M, Iwaki D, Machida T, Fujita T, and Sekine H
    • Organizer
      XXIV International Complement Workshop
    • Place of Presentation
      Hania, Greece
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] IRF-4欠損MRL/lprマウスはTh1過剰応答を起こし複数の組織に肉芽腫生病変を発症する2011

    • Author(s)
      町田豪,本間季里,松山俊文,由井克之, Ruiz Phil,藤田禎三,Gilkeson Gary,関根英治
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張,千葉
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] IRF-4はMRL/lprマウスのB細胞分化・成熟に必須である2011

    • Author(s)
      町田豪,山内直人,関根英治
    • Organizer
      基礎合同セミナーポスター発表会2011
    • Place of Presentation
      福島
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in murine models of systemic lupus erythematosus2011

    • Author(s)
      Hideharu Sekine, Phil Ruiz, Gary S. Gilkeson, and Stephen Tomlinson
    • Organizer
      The 5th Complement Workshop
    • Place of Presentation
      Ixia, Rhodes, Greece
    • Year and Date
      2011-06-23
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] Interferon regulatory factor-4 deficient lupus-prone MRL/Lpr mice show strong propensity for Th1 polarity and develop granulomatous lesions in multiple organs2011

    • Author(s)
      Sekine H, Machida T, Suzuki E, Reilly C, Zhang X, Ruiz P, Gilkeson GS
    • Organizer
      American College of Rheumatology (ACR) Scientific Meeting
    • Place of Presentation
      Chicago, USA
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] Interferon regulatory factor-4 deficient lupus-prone MRL/lpr mice show strong propensity for Th1 polarity and develop granulomatous lesions in multiple organs2011

    • Author(s)
      Hideharu Sekine, Takeshi Machida, Eiji Suzuki, Christopher Reilly, Xian Zhang, Phil Ruiz and Gary S. Gilkeson
    • Organizer
      The 75th Annual Meeting of the American College of Rheumatology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-11-06
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in murine models of systemic lupus erythematosus2011

    • Author(s)
      Sekine H, Ruiz P, Gilkeson GS, Tomlinson S
    • Organizer
      5th International Complement Therapeutics Conference
    • Place of Presentation
      Rhodes, Greece
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] IRF-4 deficient lupus-prone MRL/lpr mice develop granulomatous lesions in multiple organs with strong propensity for Th1 polarity2011

    • Author(s)
      Takeshi Machida, Kiri Honma, Toshifumi Matsuyama, Katsuyuki Yui, Phil Ruiz, Teizo Fujita, Gary Gilkeson, and Hideharu Sekine
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉 幕張メッセ
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] Targeted inhibition of the alternative pathway ameliorates progression of renal disease in murine models of systemic lupus erythematosus2010

    • Author(s)
      関根英治
    • Organizer
      XXIII International Complement Workshop
    • Place of Presentation
      New York, USA
    • Year and Date
      2010-08-03
    • Data Source
      KAKENHI-PROJECT-21890204
  • [Presentation] 転写因子IRF4欠損SLEモデルマウスが示唆するループス腎炎の新たなメカニズム2010

    • Author(s)
      関根英治
    • Organizer
      Rheumatology Conference 2010
    • Place of Presentation
      東京
    • Year and Date
      2010-06-26
    • Data Source
      KAKENHI-PROJECT-21890204
  • [Presentation] IRF4-deficient lupus-prone MRL/lpr mice lack serum immunoglobulin and glomerular immune complex/C3 deposits but develop diffuse proliferative glomerulonephritis and dermatitis/ear necrosis2010

    • Author(s)
      関根英治
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-08-23
    • Data Source
      KAKENHI-PROJECT-21890204
  • [Presentation] IRF4-Deficient lupus-prone MRL/lpr Mice lack serum Ig/auto-Abs and Th17 cells but develop non-immune complex-mediated diffuse proliferative glomerulonephritis and dermatitis/ear necrosis, American College of Rheumatology2010

    • Author(s)
      関根英治
    • Organizer
      74^<th> Annual Scientific Meeting
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2010-11-08
    • Data Source
      KAKENHI-PROJECT-21890204
  • [Presentation] IRF4-Deficient lupus-prone MRL/lpr Mice lack serum Ig/auto-Abs and Th17 Cells but develop non-immune complex-mediated diffuse proliferative glomerulonephritis and dermatitis/ear necrosis2010

    • Author(s)
      Hideharu Sekine
    • Organizer
      American College of Rheumatology 74^<th> Annual Scientific Meeting
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2010-11-08
    • Data Source
      KAKENHI-PROJECT-21890204
  • [Presentation] ループス腎炎と補体・補体第2経路を特異的に標的とする治療戦略2010

    • Author(s)
      関根英治
    • Organizer
      第47回 補体シンポジウム
    • Place of Presentation
      福島
    • Year and Date
      2010-09-10
    • Data Source
      KAKENHI-PROJECT-21890204
  • [Presentation] IRF4-deficient lupus-prone MRL/lpr mice lack serum immunoglobulin and glomerular immune complex/C3 deposits but develop diffuse proliferative glomerulonephritis and dermatitis/ear necrosis.2009

    • Author(s)
      関根英治
    • Organizer
      Immunodeficiencies and Autoimmune Diseases Scientific Colloquium
    • Place of Presentation
      The InterContinental Harbor Court, Baltimore, USA
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-21890204
  • [Presentation] Autoantibody-secreting marginal zone B cells develop significantly in lupus-prone MRL/lpr mice but not associated with expression of IFN-γ-receptor-1 on their surfaces.

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Tomoko Omori, and Hideharu Sekine
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Presentation] 転写因子IRF-4欠損SLEモデルマウスにおける CD4陽性T細胞の動態と、疾患表現型の変化

    • Author(s)
      関根 英治
    • Organizer
      第七回自己免疫疾患研究会
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591442
  • [Presentation] Takeshi Machida, Natsumi Sakamoto, Gary S. Gilkeson, and Hideharu Sekine, A dual role for IFN-γ in development of peripheral B cells in lupus-prone MRL/lpr mice.

    • Author(s)
      Takeshi Machida, Natsumi Sakamoto, Gary S. Gilkeson, and Hideharu Sekine
    • Organizer
      2014-Annual Scientific Meeting of the American College of Rheumatology
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2014-11-13 – 2014-11-18
    • Data Source
      KAKENHI-PROJECT-26670478
  • 1.  MACHIDA TAKESHI (80583632)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 20 results
  • 2.  Tetsuju Sekiryu (00216540)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 3.  Kojima Yoshiyuki (60305539)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  秦 淳也 (00769606)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 5.  錫谷 達夫 (40196895)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  赤井畑 秀則 (70644178)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 7.  YUI Katsuyuki (90274638)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 8.  HONMA Kiri (70307940)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 9.  TAKAHASHI MINORU (00285024)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 10.  大口 泰治 (90595331)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  小島 彰 (30528237)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  菅野 幸紀 (40644828)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  林 学 (80745787)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 14.  羽賀 宣博 (50586617)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  石橋 啓 (90347211)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 16.  大森 智子 (50754222)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 17.  佐藤 雄一 (00706848)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  胡口 智之 (40791950)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  星 誠二 (70813137)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  松岡 香菜子 (70838193)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  本田 瑠璃子 (80813138)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  小林 和人 (90211903)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  片岡 政雄 (90554204)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  GARY GILKESON
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  ENDO Yuichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  GI Min
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  安河内 篤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  小路 武彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  鰐渕 英機
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  石井 文人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  笠井 暁仁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 32.  村上 明子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  関亦 正幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  伊川 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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※ この処理は、研究者本人だけが実行できます。

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