Kuwabara Yoshimitsu 桑原慶充

… Alternative Names

KUWABARA Yoshimitsu 桑原慶充

桑原慶充クワバラヨシミツ

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Researcher Number	40373013
Other IDs
Affiliation (Current)	2025: 日本医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 日本医科大学, 医学部, 准教授 2013 – 2016: 日本医科大学, 医学部, 准教授 2012: 日本医科大学, 医学部, 講師 2004: 日本医大, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Obstetrics and gynecology
Keywords	Principal Investigator プロゲステロン / 頸管熟化 / 頸管リモデリング / 早産予防 / 脱落膜化障害 / エピジェネティック変容 / 不飽和脂肪酸 / 脱落膜化 / 慢性子宮内膜炎 / プロゲステロン消退 / 無菌性炎症応答 / 細胞外マトリクス / 子宮頸管 … More Except Principal Investigator … More 自然免疫 / HMGB1 / 早産 / 無菌性炎症 / NKT細胞 / 樹状細胞 / 不育症 / 炎症 / アラーミン / 生殖免疫 / マクロファージ / 流産 / 抗リン脂質抗体症候群 / OHSS / 調節卵巣刺激 / VEGF / オステオポンチン / 生殖補助医療 / MHCクラスⅡ / SN-APS / ネオ・セルフ / 自己免疫疾患 / プロゲステロン / 発症機序 / 内膜症性卵巣囊腫 / 卵巣内膜症性嚢胞 / 子宮内膜症性嚢胞 / 獲得免疫 / 子宮内膜症 / preterm birth / sterile inflammation / 子宮筋層 / 樹状細胞遊走因子 / 子宮形成術 / 着床不全 / RANTES / CD141+ 樹状細胞（DC） / 子宮鏡下中隔切除術 / ケモカインレセプター / ケモカイン / 中隔子宮 / プロテオミクス / 病態責任分子 / 血清学的陰性 / 補体分子C9 / 血清学的陰性APS / 抗リン脂質抗体症候群（APS) Less

Establishment of a new therapeutic strategy for preterm labor focused on anti-inflammation
- Principal Investigator
  
  根岸靖幸
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
新たな視点から調節卵巣刺激への反応性を予測する血中オステオポンチンの測定意義
- Principal Investigator
  
  中尾仁彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
慢性子宮内膜炎におけるエピジェネティック変容とプロゲステロン不応機序の解明Principal Investigator
- Principal Investigator
  
  桑原慶充
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
原因不明不育症おける“ネオセルフ”抗体産生機構による病原性自己抗体－抗原の探索
- Principal Investigator
  
  片山映
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
New therapeutic strategies for miscarriage and preterm birth by regulation of innate immunity
- Principal Investigator
  
  Negishi Yasuyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
Sterile Inflammation - A novel approach to preterm birth -
- Principal Investigator
  
  SHIMA YOSHIO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nippon Medical School
Novel mechanism of endometrial ovarian cyst related to sterile inflammation
- Principal Investigator
  
  Ikeda Mariko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
Elucidation of sterile inflammation in the cervix and its control mechanism to establish the molecular basis for a novel strategy to prevent preterm birthPrincipal Investigator
- Principal Investigator
  
  Kuwabara Yoshimitsu
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
Analysis of possible mechanism of miscarriage in women with septate uterus
- Principal Investigator
  
  Takeshita Toshiyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
A basic and clinical approach to risk factors of recurrent pregnancy loss – Identification of a novel antibody associated with seronegative obstetric antiphospholipid syndrome (SN-APS)
- Principal Investigator
  
  Takesshita Toshiyuki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nippon Medical School
The molecular mechanism of progesterone signaling to modulate cervical remodelingPrincipal Investigator
- Principal Investigator
  
  KUWABARA Yoshimitsu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nippon Medical School
スーパーオキサイド発生に伴う、胎盤組織における蛋白質動態のプロテオーム解析Principal Investigator
- Principal Investigator
  
  桑原慶充
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nippon Medical School

All 2022 2021 2020 2019 2017 2016 2014 Other

All Journal Article Presentation Book

[Book] 早産のすべて2020
- Author(s)
  桑原慶充、杉田洋佑
- Publisher
  MEDICAL VIEW
- Data Source
  KAKENHI-PROJECT-18K09239
[Journal Article] Upregulated serum granulysin levels in women with antiphospholipid antibody‐associated recurrent miscarriage are downregulated by heparin treatment2022
- Author(s)
  Ichikawa Tomoko、Negishi Yasuyuki、Kasano Sayuri、Yokote Ryoko、Yonezawa Mirei、Ouchi Nozomi、Kuwabara Yoshimitsu、Suzuki Shunji、Takeshita Toshiyuki
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 21 Issue: 1 Pages: 1-9
- DOI
  10.1002/rmb2.12460
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16867, KAKENHI-PROJECT-20K09679
[Journal Article] 子宮頸管熟化制御とその破綻による早産誘導メカニズムの解明2021
- Author(s)
  桑原慶充　杉田洋佑
- Journal Title
  
  東京産婦人科医会誌
  
  Volume: 54 Pages: 109-113
- Data Source
  KAKENHI-PROJECT-18K09239
[Journal Article] Inappropriate activation of invariant natural killer T cells and antigen‐presenting cells with the elevation of HMGB1 in preterm births without acute chorioamnionitis2020
- Author(s)
  Kato Masahiko、Negishi Yasuyuki、Shima Yoshio、Kuwabara Yoshimitsu、Morita Rimpei、Takeshita Toshiyuki
- Journal Title
  
  American Journal of Reproductive Immunology
  
  Volume: 85 Issue: 1
- DOI
  10.1111/aji.13330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08331, KAKENHI-PROJECT-20K09679
[Journal Article] Distribution of dendritic cells in the septate uterus: An immunological perspective.2020
- Author(s)
  Negishi Y1,2, Kato M2, Ono S2, Kuwabara Y2, Morita R1, Takahashi H1, Takeshita T2.
- Journal Title
  
  Am J Reprod Immunol.
  
  Volume: e13241 Issue: 6
- DOI
  10.1111/aji.13241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09304, KAKENHI-PROJECT-16H05178
[Journal Article] 黄体ホルモン切迫早産と黄体ホルモン2019
- Author(s)
  中井章人, 桑原慶充
- Journal Title
  
  最新女性医療
  
  Volume: 6 Pages: 18-23
- Data Source
  KAKENHI-PROJECT-18K09239
[Journal Article] Is hysteroscopic metroplasty using the incision method for septate uterus a risk factor for adverse obstetric outcomes?2019
- Author(s)
  Ono Shuichi、Kuwabara Yoshimitsu、Matsuda Shigeru、Yonezawa Mirei、Watanabe Kenichiro、Akira Shigeo、Takeshita Toshiyuki
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 45 Issue: 3 Pages: 634-639
- DOI
  10.1111/jog.13884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09304
[Journal Article] Search for pathology-related molecules in seronegative obstetric antiphospholipid syndrome using two-dimensional immunoblotting.2016
- Author(s)
  Yoshimitsu Kuwabara,Akira Katayama,Sachiko Kurihara,Mirei Yonezawa,Nozomi Ouchi,Toshiyuki Takeshita
- Journal Title
  
  Journal of Reproductive Immunology
  
  Volume: 118 Pages: 116-116
- DOI
  10.1016/j.jri.2016.10.024
- Data Source
  KAKENHI-PROJECT-25462578
[Journal Article] Progesterone transcriptionally inhibits LPS-induced matrix metalloproteinase up-regulation in human cervical fibroblast cells2014
- Author(s)
  Y. Kuwabaracorrespondence, A. Katayama, S. Kurihara, M. Yonezawa, N. Ouchi, R. Sawa, T. Takeshita
- Journal Title
  
  Journal of Reproductive Immunology
  
  Volume: 106 Pages: 16-17
- DOI
  10.1016/j.jri.2014.09.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592488
[Presentation] シンポジウム：「頸管縫縮、一歩前へ！」経腹的頸管縫縮術の適応と実際2022
- Author(s)
  桑原慶充
- Organizer
  日本早産学会
- Data Source
  KAKENHI-PROJECT-18K09239
[Presentation] Progesterone responsiveness change associated with cervical ripening observed in cultured human cervical fibroblasts.2021
- Author(s)
  Sugita Yosuke, Kuwabara Yoshimitsu, Oishi Yumiko, Takeshita Toshiyuki.
- Organizer
  The 73rd Annual Congress of the Japan Society of Obstetrics and Gynecology.
- Data Source
  KAKENHI-PROJECT-18K09239
[Presentation] Progesterone withdrawal induces eosinophilic inflammation in the process of mouse cervical ripening.2021
- Author(s)
  Sugita Yosuke, Kuwabara Yoshimitsu, Oishi Yumiko, Takeshita Toshiyuki.
- Organizer
  68th Annual Meeting of the Society for Reproductive Investigation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09239
[Presentation] Progesterone responsiveness change associated with cervical ripening using a human cervical fibroblast culture system2020
- Author(s)
  Yosuke Sugita, Yoshimitsu Kuwabara, Yumiko Oishi, Toshiyuki Takeshita
- Organizer
  第73回日本産科婦人科学会・学術講演会
- Data Source
  KAKENHI-PROJECT-18K09239
[Presentation] プロゲステロンによるα-GC誘導性マウス流産の予防効果-新たな治療作用点を探る2020
- Author(s)
  根岸靖幸、桑原慶充、竹下俊行、森田林平
- Organizer
  第28回日本胎盤学会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] ヒト子宮頸部線維芽細胞を用いた頸管熟化に伴うプロゲステロン応答性および潜在的な炎症性変化の検証2020
- Author(s)
  杉田　洋佑、桑原　慶充、大石　由美子、竹下　俊行
- Organizer
  第35回本生殖免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K09239
[Presentation] A proteomic approach to identify pathology-related molecules in patients with seronegative obstetric antiphospholipid syndrome2017
- Author(s)
  Yoshimitsu Kuwabara, Marie Ito, Mirei Yonezawa, Nozomi Ouchi, Ryuhei Kurashina, Tomoko Ichikawa, Misao Satomi, Rintaro Sawa, Toshiyuki Takeshita
- Organizer
  第69回日本産科婦人科学会総会・学術集会
- Place of Presentation
  広島グリーンアリーナ
- Year and Date
  2017-04-16
- Data Source
  KAKENHI-PROJECT-25462578
[Presentation] 二次元免疫ブロッティングを用いた、Seronegative obstetrical antiphospholipid syndromeにおける病態関連分子の探索2016
- Author(s)
  桑原慶充,片山映,栗原佐知子,米澤美令,大内望,竹下俊行
- Organizer
  第31回日本生殖免疫学会総会・学術集会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-25462578
[Presentation] プロゲステロンは、ヒト子宮頚部線維芽細胞培養系においてTLR4誘導性のMMP群の発現を転写レベルで抑制する2014
- Author(s)
  桑原慶充, 米澤美令, 渡邉建一郎, 小野修一, 大内望, 澤倫太郎, 中井章人, 竹下俊行
- Organizer
  第50回日本周産期・新生児医学会学術集会2014
- Place of Presentation
  舞浜
- Data Source
  KAKENHI-PROJECT-24592488
[Presentation] 培養ヒト子宮頸部線維芽細胞におけるLPS誘導性分子動態に対するプロゲステロンの効果
- Author(s)
  桑原慶充, 杉田洋佑, 内山美穂子, 白井有香, 中尾仁彦, 　米澤美令, 大内望, 澤倫太郎, 中井章人, 竹下俊行
- Organizer
  日本産科婦人科学会　学術集会
- Place of Presentation
  横浜
- Year and Date
  2015-04-09 – 2015-04-12
- Data Source
  KAKENHI-PROJECT-24592488
[Presentation] The effects of progesterone on the gene expression profile of LPS- stimulated cultured human cervical fibroblasts
- Author(s)
  Yoshimitsu Kuwabara, Akira Katayama, Sachiko Kurihara, Yosuke Sugita, Yuka Shirai, Kimihiko Nakao, Mirei Yonezawa, Nozomi Ouch1, Rintaro Sawa, Toshiyuki Takeshita
- Organizer
  Society for Reproductive Investigation
- Place of Presentation
  サンフランシスコ
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24592488
[Presentation] プロゲステロンはヒト子宮頸部線維芽細胞培養系において、LPS誘導性MMP群の発現を転写レベルで抑制する
- Author(s)
  桑原慶充, 片山映, 米澤美令, 大内望, 澤倫太郎, 中井章人, 竹下俊行
- Organizer
  日本生殖免疫学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2014-12-12 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-24592488

1. KATAYAMA Akira (10333113)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. Negishi Yasuyuki (50644580)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
3. TAKESHITA Toshiyuki (60188175)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
4. 杉田洋佑 (60774354)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAKAI Akihito (20227721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. KAWABATA Ikuno (20328793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SHIMA YOSHIO (70714765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. Ikeda Mariko (10740988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 峯克也 (60409216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 小野修一 (80465301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 明樂重夫 (40231849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中尾仁彦 (20591267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 加藤雅彦 (90614751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 市川智子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuwabara Yoshimitsu 桑原 慶充

KUWABARA Yoshimitsu 桑原 慶充

桑原 慶充 クワバラ ヨシミツ

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慢性子宮内膜炎におけるエピジェネティック変容とプロゲステロン不応機序の解明Principal Investigator

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Elucidation of sterile inflammation in the cervix and its control mechanism to establish the molecular basis for a novel strategy to prevent preterm birthPrincipal Investigator

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The molecular mechanism of progesterone signaling to modulate cervical remodelingPrincipal Investigator

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スーパーオキサイド発生に伴う、胎盤組織における蛋白質動態のプロテオーム解析Principal Investigator

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[Book] 早産のすべて2020

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[Journal Article] Upregulated serum granulysin levels in women with antiphospholipid antibody‐associated recurrent miscarriage are downregulated by heparin treatment2022

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[Journal Article] 子宮頸管熟化制御とその破綻による早産誘導メカニズムの解明2021

Kuwabara Yoshimitsu 桑原慶充

KUWABARA Yoshimitsu 桑原慶充

桑原慶充クワバラヨシミツ

[Journal Article] 黄体ホルモン切迫早産と黄体ホルモン2019

[Presentation] シンポジウム：「頸管縫縮、一歩前へ！」経腹的頸管縫縮術の適応と実際2022