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Maemoto Atsuo  前本 篤男

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前本 篤男  マエモト アツオ

MAEMOTO Atsuo  前本 篤男

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Researcher Number 40400113
Other IDs
External Links
Affiliation (Current) 2025: 医療法人徳洲会札幌東徳洲会病院医学研究所, IBD・免疫研究部, 部門長
2025: 医療法人徳洲会札幌東徳洲会病院医学研究所, IBD研究部, 部門長
Affiliation (based on the past Project Information) *help 2017: 医療法人徳洲会札幌東徳洲会病院医学研究所, IBD研究部, 部門長
2015 – 2016: 医療法人徳洲会札幌東徳洲会病院付属臨床研究センター, IBD研究部, 部門長
2013: 旭川医科大学, 医学部, その他
2013: 旭川医科大学, 医学部, 客員教授
2007 – 2012: Asahikawa Medical College, Internal Medicine, Visiting associate professor
2006 – 2007: 旭川医科大学, 医学部, 特任講師
2006: 旭川医科大学, 医学部, 寄附講座教員
Review Section/Research Field
Except Principal Investigator
Gastroenterology / Applied biochemistry / Biological Sciences
Keywords
Except Principal Investigator
炎症性腸疾患 / 腸内細菌 / 自然免疫 / Heat shock protein / 抗菌ペプチド / Bacillus subtilis / OCTN / 腸内環境 / 悪性化 / 膵癌 … More / 医食同源 / 腸内細菌叢 / 膵がん / 膵腸相関 / Host-bacterial interaction / Cell membrane transporter / Probiotics / Enteric microflora / Oragnic cation transporter / Organic Cation Transporters / 宿主-細菌相互作用 / 細胞膜トランスポーター / プロバイオティクス / Organic cation transporters / Himan defensin 5 / Alpha-defensins / Crohn's disease / Innate immunity / Antibacterial peptides / Inflammatory Bowel Disease / 病原体認識 / ディフェンシン / 粘膜免疫 / デフェンシン / 潰瘍性大腸炎 / 内因性抗菌ペプチド / Human defensin 5 / alpha-defensin / クローン病 / トランスポーター / バイオフィルム / Comnetence and soorulation factor / Competence and Sporulation factor / Cometence and sorulation factor / MDR-1 / 腸内細菌とトランスポーター / 乳酸菌 / バシラス菌 / Competence and sporulation factor / Human defensin / 炎症性腸疾 / 消化器学(食道,胃,小腸,大腸) / Sonic hedgehog / 血管内皮前駆細胞 / 血管新生 / がん Less
  • Research Projects

    (7 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (12 People)
  •  Pancreatic-Intestinal Crosstalk: a novel approach to elucidate the tumorigenic process of PDAC

    • Principal Investigator
      ONO Yusuke
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Applied biochemistry
    • Research Institution
      Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital
  •  Cytoprotective effects of bioactive molecules derived from bacteria in the intestinal biofilm

    • Principal Investigator
      KOHGO Yutaka
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Asahikawa Medical College
  •  Dynamic status of bacterial products transported by OCTNs or MDR-1 in normal and inflamed intestinal epithelia

    • Principal Investigator
      FUJIYA Mikihiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Asahikawa Medical College
  •  Development of a novel treatment for inflammatory bowel disease via the regulation of the bacteria recognition system and effective molecules derived from bacteria

    • Principal Investigator
      KOHGO Yutaka
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Asahikawa Medical College
  •  ヒト血管内皮前駆細胞の可塑性に起因するがん微小環境の異常とその制御

    • Principal Investigator
      水上 裕輔
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Asahikawa Medical College
  •  OCTN regulates intestinal homeostasis through the transport of bacterial products.

    • Principal Investigator
      FUJIYA Mikihiro
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Asahikawa Medical College
  •  The role of innate immunity in inflammatory bowel disease

    • Principal Investigator
      KOHGO Yutaka
    • Project Period (FY)
      2003 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Asahikawa Medical College

All 2012 2010 2008 2007 Other

All Journal Article Presentation

  • [Journal Article] Paneth Cells Regulate Both Chemotaxis of Immature Dendritic Cells and Cytokine Production from Epithelial Cells2012

    • Author(s)
      Ito T, Ayabe T, Ishikawa C, Inaba Y, Tanabe H, Maemoto A, Kono T, Ashida T, Fujiya M, Kohgo Y.
    • Journal Title

      Tohoku J. Exp. Med.

      Volume: 227 Issue: 1 Pages: 39-48

    • DOI

      10.1620/tjem.227.39

    • NAID

      130004459980

    • ISSN
      0040-8727, 1349-3329
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390148, KAKENHI-PROJECT-23390193, KAKENHI-PROJECT-23590931
  • [Journal Article] Isoleucine, an essential amino acid, induces the expression of human  defensin 2 through the activation of the G-protein coupled receptor-ERK pathway in the intestinal epithelia.2012

    • Author(s)
      Konno Y, Ashida T, Inaba Y, Ito T, Tanabe H, Maemoto A, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y.
    • Journal Title

      Food and Nutrition Sciences

      Volume: 3 Issue: 04 Pages: 548-555

    • DOI

      10.4236/fns.2012.34077

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390148, KAKENHI-PROJECT-23590931
  • [Journal Article] Isoleucine, an essential amino acid, induces the expression of human ・ defensin 2 through the activation of the G-protein coupled receptor-ERK pathway in the intestinal epithelia2012

    • Author(s)
      Konno Y, Ashida T, Inaba Y, Ito T, Tanabe H, Maemoto A, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y
    • Journal Title

      Food and Nutrition Sciences

      Volume: 3(4) Pages: 548-555

    • Data Source
      KAKENHI-PROJECT-22390148
  • [Journal Article] Paneth cell regulate gut inflammation, thereby inducing chemotaxis of dendritic cells and cytokine production from epithelial cells2012

    • Author(s)
      Ito T, Ayabe T, Ishikawa C, Inaba Y, Tanabe H, Maemoto A, Kono T, Ashida T, Fujiya M, Kohgo Y
    • Journal Title

      Tohoku Journal of ExperimentalMedicine

      Volume: 227(1) Pages: 39-48

    • Data Source
      KAKENHI-PROJECT-22390148
  • [Journal Article] The expression of the anti-microbial peptide α-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10 deficient mice2010

    • Author(s)
      Inaba Y, Ashida T, Ito T, Ishikawa C, Tanabe H, Maemoto A, Watari J, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y
    • Journal Title

      Inflammatory Bowel Diseases

      Volume: 16(9) Pages: 1488-1495

    • Data Source
      KAKENHI-PROJECT-22390148
  • [Journal Article] Precursor Processing of Human Defensin-5 Is Essential to the Multiple Functions in vitro and in vivo.2010

    • Author(s)
      Ishikawa C, Tanabe H, Maemoto A, Ito T, Watari J, Kono T, Fujiya M, Ashida T, Ayabe T, Kohgo Y.
    • Journal Title

      J Innate Immunity 2

      Pages: 66-76

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590734
  • [Journal Article] Precursor Processing of Human Defensin-5 Is Essential to the Multiple Functions in vitro and in vivo.2010

    • Author(s)
      Ishikawa C, Maemoto A, Fujiya M, Ashida T, Kohgo Y
    • Journal Title

      J Innate Immunity 2

      Pages: 66-76

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590734
  • [Journal Article] Precursor Processing of Human Defensin-5 Is Essential to the Multiple Functions in vitro and in vivo.2010

    • Author(s)
      Ishikawa C, Maemoto A, Fujiya M, Ashida T, Kohgo Y
    • Journal Title

      J Innate Immunity 2

      Pages: 66-76

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390194
  • [Journal Article] The expression of the anti-microbial peptide α-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10 deficient mice.2010

    • Author(s)
      Inaba Y, Ashida T, Ito T, Ishikawa C, Tanabe H, Maemoto A, Watari J, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y
    • Journal Title

      Inflammatory Bowel Diseases 16(9)

      Pages: 1488-95

    • Data Source
      KAKENHI-PROJECT-19390194
  • [Journal Article] Precursor Processing of Human Defensin-5 Is Essential to the Multiple Functions in vitro and in vivo.2010

    • Author(s)
      Ishikawa C, Tanabe H, Maemoto A, Ito T, Watari J, Kono T, Fujiya M, Ashida T, Ayabe T, Kohgo Y
    • Journal Title

      J Innate Immunity 2

      Pages: 66-76

    • Data Source
      KAKENHI-PROJECT-19390194
  • [Journal Article] Precursor Processing of Human Defensin-5 Is Essential to the Multiple Functions in vitro and in vivo2010

    • Author(s)
      Ishikawa C, Tanabe H, Maemoto A, Ito T, Watari J, Kono T, Fujiya M, Ashida T, Ayabe T, Kohgo Y.
    • Journal Title

      J Innate Immunity 2

      Pages: 66-76

    • Data Source
      KAKENHI-PROJECT-19390194
  • [Journal Article] Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells2008

    • Author(s)
      Yamazaki M, Nakamura K, Mizukami Y, Ii M, Sasajima J, Sugiyama Y, NishikawaN, Nakano Y, Yanagawa N, Sato K, Maemoto A, Karasaki H, Kono T, Fujiya M, Ashida T, Chung DC, Kohgo Y.
    • Journal Title

      Cancer Science 99(6)

      Pages: 1131-8

    • NAID

      10024007112

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390194
  • [Journal Article] Clinicopathological implications in genetic instability in intestinal type gastric cancer and intestinal metaplasia as a precancerous lesion : Proof of field cancerization in the stomach2008

    • Author(s)
      Zaky A, Watari J, Tanabe H, Sato R, Moriichi K, Tanaka A, Maemoto A, Fujiya M, Ashida T, Kohgo Y.
    • Journal Title

      Am J Clin Pathol 129(4)

      Pages: 613-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390194
  • [Journal Article] Functional Role of Metaplastic Paneth Cell Defensins in Helicobacter pylori-Infected Stomach2008

    • Author(s)
      Hiroki Tanabe, Tomonobu Sato, Jiro Watari, Atsuo Maemoto, Mikihiko Fijiya, Toru Kono, Toshifumi Ashida, Tokiyoshi Ayabe and Yutaka Kohgo.
    • Journal Title

      Helicobactor 13

      Pages: 370-379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590734
  • [Journal Article] Clinicopathological implications in genetic instability in intestinal type gastric cancer andi intestinal metaplasia as a precancerous lesion:Proof of field cancerization in the stomach.2008

    • Author(s)
      Zaky A, Watari J, Tanabe H, Sato R, Moriichi K, Tanaka A, Maemoto A, Fujiya M, et. al.
    • Journal Title

      Am J Clin Pathol 129(4)

      Pages: 613-21

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590667
  • [Journal Article] Functional role of metaplastic paneth cell defensins in Helicobacter pylori-infected stomach.2008

    • Author(s)
      Tanabe H, Maemoto A, Fijiya M, Ashida T, Kohgo Y
    • Journal Title

      Helicobacter. 13(5)

      Pages: 70-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390194
  • [Journal Article] Transnasal ultrathin endoscopy for placement of a long intestinal tube in patients with intestinal obstruction2008

    • Author(s)
      Sato R, Watari J, Tanabe H, Fujiya M, Ueno N, Konno Y, Ishikawa C, Ito T, Moriichi K, Okamoto K, Maemoto A, Chisaka K, Kitano Y, Matsumoto K, Ashida T, Kono T, Kohgo Y.
    • Journal Title

      Gastrointest Endosc 67(6)

      Pages: 953-957

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590734
  • [Journal Article] Transnasal ultrathin endoscopy for placement of a long intestinal tube in patients with intestinal obstruction.2008

    • Author(s)
      Sato R, Watari J, Tanabe H, Fujiya M, Ueno N, Konno Y, Ishikawa C, Ito T, Moriichi K, Okamoto K, Maemoto A, Chisaka K, Kitano Y, Matsumoto K, Ashida T, Kono T, Kohgo Y
    • Journal Title

      Gastrointest Endosc 67(6)

      Pages: 953-957

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590734
  • [Journal Article] Functional Role of Metaplastic Paneth Cell Defensins in Helicobacter pylori-Infected Stomach2008

    • Author(s)
      Hiroki Tanabe, Tomonobu Sato,Jiro Watari, Atsuo Maemoto, Mikihiko Fijiya, Toru Kono, Toshifumi Ashida, Tokiyoshi Ayabe and Yutaka Kohgo
    • Journal Title

      Helicobactor 13

      Pages: 370-379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390194
  • [Journal Article] Functional role of metaplastic paneth cell defensins in Helicobacter pylori-infected stomach.2008

    • Author(s)
      Tanabe H, Maemoto A, Fijiya M, Ashida T, Kohgo Y
    • Journal Title

      Helicobacter. 13(5)

      Pages: 370-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590734
  • [Journal Article] Clinicopathological implications in genetic instability in intestinal type gastric cancer and intestinal metaplasia as a precancerous lesion: Proof of field cancerization in the stomach.2008

    • Author(s)
      Zaky A. Watari J, Tanabe H, Sato R, Moriichi K, Tanaka A, Maemoto A, Fujiya M, et. al.
    • Journal Title

      Am J Clin Pathol 129(4)

      Pages: 613-621

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590667
  • [Journal Article] Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion2007

    • Author(s)
      Tanabe H, Ayabe T, Maemoto A, Ishikawa C, Inaba Y, Sato R, Moriichi K, Okamoto K, Watari J, Kono T, Ashida T, Kohgo Y.
    • Journal Title

      Biochem Biophys Res Commun 358

      Pages: 349-355

    • Data Source
      KAKENHI-PROJECT-19390194
  • [Journal Article] Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion.2007

    • Author(s)
      Tanabe H, Maemoto A, Ashida T, Kohgo Y
    • Journal Title

      Biochem Biophys Res Commun. 358(1)

      Pages: 349-55

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390194
  • [Journal Article] Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion.2007

    • Author(s)
      Tanabe H, Ayabe T, Maemoto A, Ishikawa C, Inaba Y, Sato R, Moriichi K, Okamoto K, Watari J, Kono T, Ashida T, Kohgo Y.
    • Journal Title

      Biochem Biophys Res Commun. 358(1)

      Pages: 349-55

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390194
  • [Journal Article] Clinicopathological implications in genetic instability in intestinal type gastric cancer and intestinal metaplasia as a preccancerous lesion: Proof of field cancerization in the stomach.

    • Author(s)
      Zaky A, Watari J, Tanabe H, Sato R, Moriichi K, Tanaka A, Maemoto A, Fujiya M, et. al.
    • Journal Title

      Am J Clin Pathol (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590667
  • [Journal Article] The expression of the anti-microbial peptide α-defensin/cryptdins inintestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10 deficient mice

    • Author(s)
      Inaba Y, Ashida T, Ito T, Ishikawa C, Tanabe H, Maemoto A, Watari J, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y.
    • Journal Title

      Inflammatory Bowel Diseases (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590734
  • [Journal Article] The expression of the anti-microbial peptide α-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10 deficient mice

    • Author(s)
      Inaba Y, Ashida T, Ito T, Ishikawa C, Tanabe H, Maemoto A, Watari J, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y.
    • Journal Title

      Inflammatory Bowel Diseases (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390194
  • [Presentation] Effects of Helicobacter pylori Infection On Genetic Instability, Aberrant CpG Island Methylation Status and Cellular Phenotype in Intestinal M etaplasia of Barrett's Esophagus in Japanese Population: A Prospective Follow-Up Study After Eradication2008

    • Author(s)
      Moriichi K, Tanabe H, Maemoto A, Fujiya M, Ashida T, Kohgo Y, et.al.
    • Organizer
      DDW 2008 (AGA)
    • Place of Presentation
      San Diego(米国)
    • Year and Date
      2008-05-19
    • Data Source
      KAKENHI-PROJECT-20590734
  • [Presentation] Endoscopic auto fluorescence imaging is useful for detecting colonic small lesions, of lymphoma resembling lymphoid hyperplasia2008

    • Author(s)
      Ueno N, Tanabe H, Maemoto A, Fujiya M, Ashida T, Kohgo Y, et.al.
    • Organizer
      DDW 2008 (ASGE)
    • Place of Presentation
      San Diego(米国)
    • Year and Date
      2008-05-18
    • Data Source
      KAKENHI-PROJECT-20590734
  • [Presentation] Effects of Helicobacter pylori Infection On Genetic Instability, Aberrant CpG Island Methylation Status and Cellular Phenotype in Intestinal Metaplasia of Barrett's Esophagus in Japanese Population : A Prospective Follow-Up Study After Eradication2008

    • Author(s)
      Moriichi K, Tanabe H, Maemoto A, Fujiya M, Ashida T, Kohgo Y, et.al.
    • Organizer
      DDW 2008 (AGA)
    • Place of Presentation
      San Piego(米国)
    • Year and Date
      2008-05-19
    • Data Source
      KAKENHI-PROJECT-19390194
  • [Presentation] Human enteric defensin induces acquired immunity through activation processing2007

    • Author(s)
      Hiroki Tanabe, Atsuo Maemoto, Tokiyoshi Ayabe, Toru Kono, Jiro Watari, Toshifumi Ashida, Yutaka Kogo
    • Organizer
      13th International Congress of Mucosal Immunology 2007
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-19390194
  • [Presentation] Disruption of innate immunity in Crohn's disease2007

    • Author(s)
      Atsuo Maemoto, Hiroki Tanabe, Yuhei Inaba, Takahiro Ito, Toshifumi Ashida, Tokiyoshi Ayabe, Yutaka Kohgo
    • Organizer
      13th International Congress of Micosal Immunology 2007
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-19390194
  • 1.  FUJIYA Mikihiro (80322915)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 22 results
  • 2.  OHTAKE Takaaki (10359490)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  KOHGO Yutaka (10133183)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 19 results
  • 4.  ASHIDA Toshifumi (50261409)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 19 results
  • 5.  水上 裕輔 (30400089)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  UENO Nobuhiro (30436000)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  AYABE Tokiyosi (90301019)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  ONO Yusuke (40742648)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  佐藤 一也 (50360988)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  伊井 正明 (10442922)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  田邊 裕貴 (50396363)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 13 results
  • 12.  中村 公則 (80381276)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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