Fujino Hiromichi 藤野裕道

… Alternative Names

FUJINO Hiromichi 藤野裕道

藤野裕道フジノヒロミチ

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Researcher Number	40401004
Other IDs
Affiliation (Current)	2025: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授 2017: 徳島大学, 大学院医歯薬学研究部(薬学系), 教授 2012 – 2015: 千葉大学, 薬学研究科(研究院), 准教授 2010 – 2012: 千葉大学, 大学院・薬学研究院, 准教授 2007: Chiba University, 大学院・薬学研究院, 准教授 2006: 千葉大学, 大学院薬学研究院, 講師
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Pharmacology in pharmacy / Biological pharmacy
Keywords	Principal Investigator PGE2 / プロスタノイド受容体 / 大腸がん / EP4受容体 / 結腸癌 / LS174T細胞 / EP2受容体 / インドメタシン / NSAID / 大腸癌制御メカニズム解明 … More / 結腸がん / prostanoid receptors / 大腸がん発症メカニズムの解明 / がん発症メカニズムの解明 / 薬学 / 薬理学 / ２型免疫 / 大腸癌 / IL-4 / ヒスタミン / 酪酸 / DPアンタゴニスト / DAF/CD55 / 結腸癌細胞 / β－カテニン / 受容体アミノ酸変異 / 1000ゲノムプロジェクト / DP受容体 / PGD2 / バイアスリガンド / 細胞内情報伝達系 / プロスタノイド / Gタンパク質共役型受容体 / COX阻害非依存的作用 / MMP-9 / 上皮間葉転換(EMT) / PPARγ / FAT/CD36 / COX阻害非依存作用 / 脂肪細胞 / アラキドン酸 / 薬理学・細胞情報伝達学 / LS174T / COX / 結腸ガン / プロスタグランジンE2 Less

プロスタノイドEP4受容体の恒常的活性による細胞増殖速度調整メカニズムの解明Principal Investigator
- Principal Investigator
  
  藤野裕道
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  The University of Tokushima
Explore the irreversible check point from normal to malignant transformation of the cells by changing in the balance of the expression levels of the EP prostanoid receptor subtypes.Principal Investigator
- Principal Investigator
  
  FUJINO Hiromichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  The University of Tokushima
Exploring the mechanism of EP4 prostanoid receptor-evoked colorectal cancer development during the collapse of homeostasis and its ameliorating effects by substances of type 2 innate immune systemPrincipal Investigator
- Principal Investigator
  
  FUJINO Hiromichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  The University of Tokushima
Mechanisms of colon cancer malignancy regulation by two endogenous prostanoid receptorsPrincipal Investigator
- Principal Investigator
  
  FUJINO Hiromichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Chiba University
Exploring the novel cycloocygenase-inhibition-independent effects of indomethacinPrincipal Investigator
- Principal Investigator
  
  FUJINO Hiromichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
プロスタグランジンE2およびそのEP4受容体情報伝達系のガン化への関与の解明Principal Investigator
- Principal Investigator
  
  藤野裕道
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University

[Book] 薬系薬理学書（分担）２章　薬物作用の基本（２．１　薬の作用様式（薬理作用），２．２　細胞情報伝達系と受容体）2018
- Author(s)
  立川　英一、田野中　浩一、弘瀬　雅教　（分担）藤野　裕道
- Total Pages
  742
- Publisher
  南江堂
- ISBN
  9784524403295
- Data Source
  KAKENHI-PROJECT-17K08308
[Book] Assessment of constitutive activity in E-type prostanoid receptors2010
- Author(s)
  Fujino H, Murayama T, Regan JW
- Publisher
  Elsevier Inc. Methods Enzymol
- Data Source
  KAKENHI-PROJECT-22590079
[Book] Methods in Enzymology Voliume 4842010
- Author(s)
  Hiromichi Fujino, et al.
- Publisher
  Elsevier Inc.
- Data Source
  KAKENHI-PROJECT-22590079
[Journal Article] Down-regulation of the expression of cyclooxygenase-2 and prostaglandin E2 by interleukin-4 is mediated via a reduction in the expression of prostanoid EP4 receptors in HCA-7 human colon cancer cells2022
- Author(s)
  Kitagawa Kana、Hamaguchi Ayaka、Fukushima Keijo、Nakano Yuki、Regan John W.、Mashimo Masato、Fujino Hiromichi
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 920 Pages: 174863-174863
- DOI
  10.1016/j.ejphar.2022.174863
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07084, KAKENHI-PROJECT-22K15293
[Journal Article] The Biased Activities of Prostanoids and Their Receptors: Review and Beyond2022
- Author(s)
  Fujino Hiromichi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 6 Pages: 684-690
- DOI
  10.1248/bpb.b21-01052
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-06-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07084
[Journal Article] The Gαs‐protein‐mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors2022
- Author(s)
  Fukushima Keijo、Senoo Kanaho、Kurata Naoki、Regan John W.、Fujino Hiromichi
- Journal Title
  
  FEBS Open Bio
  
  Volume: 12 Issue: 4 Pages: 775-783
- DOI
  10.1002/2211-5463.13378
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16374, KAKENHI-PROJECT-20K07084, KAKENHI-PROJECT-22K15293
[Journal Article] Foreword2022
- Author(s)
  Fujino Hiromichi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 6 Pages: 668-668
- DOI
  10.1248/bpb.b22-ctf4506
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-06-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-20K07084
[Journal Article] PARP14 regulates EP4 receptor expression in human colon cancer HCA-7?cells2022
- Author(s)
  Mashimo Masato、Shimizu Asuka、Mori Aimi、Hamaguchi Ayaka、Fukushima Keijo、Seira Naofumi、Fujii Takeshi、Fujino Hiromichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 623 Pages: 133-139
- DOI
  10.1016/j.bbrc.2022.07.055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06539, KAKENHI-PROJECT-22K15293, KAKENHI-PROJECT-20K07084
[Journal Article] Identification and Characterization of Human Colorectal Cancer Cluster Predominantly Expressing EP3 Prostanoid Receptor Subtype2022
- Author(s)
  Fukushima Keijo、Fujino Hiromichi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 6 Pages: 698-702
- DOI
  10.1248/bpb.b22-00104
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-06-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15293, KAKENHI-PROJECT-20K07084
[Journal Article] The differential functional coupling of phosphodiesterase 4 to human DP and EP2 prostanoid receptors stimulated with PGD2 or PGE22021
- Author(s)
  Okura Iori、Hasuoka Nanae、Senoo Kanaho、Suganami Akiko、Fukushima Keijo、Regan John W.、Mashimo Masato、Murayama Toshihiko、Tamura Yutaka、Fujino Hiromichi
- Journal Title
  
  Pharmacological Reports
  
  Volume: - Issue: 3 Pages: 946-953
- DOI
  10.1007/s43440-021-00247-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16374, KAKENHI-PROJECT-19K07315, KAKENHI-PROJECT-20K07084, KAKENHI-PROJECT-20K21825
[Journal Article] 15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling2020
- Author(s)
  Endo Suzu、Suganami Akiko、Fukushima Keijo、Senoo Kanaho、Araki Yumi、Regan John W.、Mashimo Masato、Tamura Yutaka、Fujino Hiromichi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 38 Pages: 13338-13352
- DOI
  10.1074/jbc.ra120.013988
- NAID
  120007182108
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07315, KAKENHI-PROJECT-20K07084, KAKENHI-PROJECT-20K21825, KAKENHI-PROJECT-19K16374
[Journal Article] Why PGD 2 has different functions from PGE 22020
- Author(s)
  Fujino Hiromichi
- Journal Title
  
  BioEssays
  
  Volume: 43 Issue: 2 Pages: 2000213-2000213
- DOI
  10.1002/bies.202000213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07084
[Journal Article] Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells2019
- Author(s)
  Kurata Naoki、Tokashiki Natsumi、Fukushima Keijo、Misao Takaya、Hasuoka Nanae、Kitagawa Kana、Mashimo Masato、Regan John W.、Murayama Toshihiko、Fujino Hiromichi
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 853 Pages: 308-315
- DOI
  10.1016/j.ejphar.2019.04.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16374, KAKENHI-PROJECT-17K08308
[Journal Article] Cellular density-dependent increases in HIF-1α compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region2018
- Author(s)
  Seira N, Yamagata K, Fukushima K, Araki Y, Kurata N, Yanagisawa N, Mashimo M, Nakamura H, Regan JW, Murayama T, Fujino H
- Journal Title
  
  Pharmacol Res Perspect
  
  Volume: 6 Issue: 6
- DOI
  10.1002/prp2.441
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08303, KAKENHI-PROJECT-17K08308, KAKENHI-PROJECT-16K19206
[Journal Article] Irinotecan-induced neutropenia is reduced by oral alkalization drugs: analysis using retrospective chart reviews and the spontaneous reporting database2018
- Author(s)
  Hamano Hirofumi、Mitsui Marin、Zamami Yoshito、Takechi Kenshi、Nimura Takahiro、Okada Naoto、Fukushima Keijo、Imanishi Masaki、Chuma Masayuki、Horinouchi Yuya、Izawa-Ishizawa Yuki、Kirino Yasushi、Nakamura Toshimi、Teraoka Kazuhiko、Ikeda Yasumasa、Fujino Hiromichi、Yanagawa Hiroaki、Tamaki Toshiaki、Ishizawa Keisuke
- Journal Title
  
  Supportive Care in Cancer
  
  Volume: 27 Issue: 3 Pages: 849-856
- DOI
  10.1007/s00520-018-4367-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08308, KAKENHI-PROJECT-18K06785, KAKENHI-PROJECT-18K08480, KAKENHI-PROJECT-18K14983, KAKENHI-PROJECT-16K08549
[Journal Article] Effect of Royal Jelly and Brazilian Green Propolis on the Signaling for Histamine H<sub>1</sub> Receptor and Interleukin-9 Gene Expressions Responsible for the Pathogenesis of the Allergic Rhinitis2018
- Author(s)
  Shaha Aurpita、Mizuguchi Hiroyuki、Kitamura Yoshiaki、Fujino Hiromichi、Yabumoto Masami、Takeda Noriaki、Fukui Hiroyuki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 9 Pages: 1440-1447
- DOI
  10.1248/bpb.b18-00325
- NAID
  130007480014
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08308
[Journal Article] Renoprotective effects of a factor Xa inhibitor: fusion of basic research and a database analysis2018
- Author(s)
  Horinouchi Yuya、Ikeda Yasumasa、Fukushima Keijo、Imanishi Masaki、Hamano Hirofumi、Izawa-Ishizawa Yuki、Zamami Yoshito、Takechi Kenshi、Miyamoto Licht、Fujino Hiromichi、Ishizawa Keisuke、Tsuchiya Koichiro、Tamaki Toshiaki
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 10858-10858
- DOI
  10.1038/s41598-018-29008-2
- NAID
  120006535061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08308, KAKENHI-PROJECT-18K06686, KAKENHI-PROJECT-18K06785, KAKENHI-PROJECT-18K08480, KAKENHI-PROJECT-18K14983, KAKENHI-PROJECT-16K08549, KAKENHI-PROJECT-18K14920
[Journal Article] Effect of wild grape on the signaling of histamine H<sub>1</sub> receptor gene expression responsible for the pathogenesis of allergic rhinitis2018
- Author(s)
  Islam Rezwanul、Mizuguchi Hiroyuki、Shaha Aurpita、Nishida Kohei、Yabumoto Masami、Ikeda Hisashi、Fujino Hiromichi、Kitamura Yoshiaki、Fukui Hiroyuki、Takeda Noriaki
- Journal Title
  
  J. Med. Invest.
  
  Volume: 65 Issue: 3.4 Pages: 242-250
- DOI
  10.2152/jmi.65.242
- NAID
  130007495826
- ISSN
  1343-1420, 1349-6867
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08308
[Journal Article] Xanthine oxidase inhibition by febuxostat in macrophages suppresses angiotensin II-induced aortic fibrosis2018
- Author(s)
  Kondo Masateru、Imanishi Masaki、Fukushima Keijo、Ikuto Raiki、Murai Yoichi、Horinouchi Yuya、Izawa-Ishizawa Yuki、Goda Mitsuhiro、Zamami Yoshito、Takechi Kenshi、Chuma Masayuki、Ikeda Yasumasa、Fujino Hiromichi、Tsuchiya Koichiro、Ishizawa Keisuke
- Journal Title
  
  American Journal of Hypertension
  
  Volume: 32 Issue: 3 Pages: 249-256
- DOI
  10.1093/ajh/hpy157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08308, KAKENHI-PROJECT-18K06686, KAKENHI-PROJECT-18K08480, KAKENHI-PROJECT-17K18262, KAKENHI-PROJECT-18K14983, KAKENHI-PROJECT-16K08549, KAKENHI-PROJECT-18K14920
[Journal Article] Nitrosonifedipine, a photodegradation product of nifedipine, suppresses pharmacologically induced aortic aneurysm formation2018
- Author(s)
  Imanishi Masaki、Izawa-Ishizawa Yuki、Sakurada Takumi、Kohara Yusuke、Horinouchi Yuya、Sairyo Eriko、Zamami Yoshito、Takechi Kenshi、Chuma Masayuki、Fukushima Keijo、Ikeda Yasumasa、Fujino Hiromichi、Yoshizumi Masanori、Tsuchiya Koichiro、Tamaki Toshiaki、Ishizawa Keisuke
- Journal Title
  
  Pharmacology
  
  Volume: 102 Issue: 5-6 Pages: 287-299
- DOI
  10.1159/000492577
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08308, KAKENHI-PROJECT-18K06686, KAKENHI-PROJECT-18K06785, KAKENHI-PROJECT-18K08480, KAKENHI-PROJECT-18K14983, KAKENHI-PROJECT-16K08549, KAKENHI-PROJECT-18K14920
[Journal Article] Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest.2017
- Author(s)
  48)Niimura T, Zamami Y, Koyama T, Izawa-Ishizawa Y, Miyake M, Koga T, Harada K, Ohshima A, Imai T, Kondo Y, Imanishi M, Takechi K, Fukushima K, Horinouchi Y, Ikeda Y, Fujino H, Tsuchiya K, Tamaki T, Hinotsu S, Kano MR, Ishizawa K.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 17919-17919
- DOI
  10.1038/s41598-017-17686-3
- NAID
  120006535027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08549, KAKENHI-PROJECT-17K08308, KAKENHI-PROJECT-15K01716, KAKENHI-PROJECT-15K07967, KAKENHI-PROJECT-15K21178, KAKENHI-PROJECT-16K16603
[Journal Article] Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line2017
- Author(s)
  Seira Naofumi、Yanagisawa Naoki、Suganami Akiko、Honda Takuya、Wasai Makiko、Regan John W.、Fukushima Keijo、Yamaguchi Naoto、Tamura Yutaka、Arai Takayoshi、Murayama Toshihiko、Fujino Hiromichi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 10 Pages: 1806-1812
- DOI
  10.1248/bpb.b17-00458
- NAID
  130006110584
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08542, KAKENHI-PROJECT-17K08308, KAKENHI-PROJECT-16J04141, KAKENHI-PROJECT-15K07922
[Journal Article] PGE1 and E3 show lower efficacies than E2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors2017
- Author(s)
  Araki Yumi、Suganami Akiko、Endo Suzu、Masuda Yuta、Fukushima Keijo、Regan John W.、Murayama Toshihiko、Tamura Yutaka、Fujino Hiromichi
- Journal Title
  
  FEBS Lett.
  
  Volume: 591 Issue: 22 Pages: 3771-3780
- DOI
  10.1002/1873-3468.12878
- NAID
  130007900719
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08542, KAKENHI-PROJECT-17K08308, KAKENHI-PROJECT-17H04316
[Journal Article] The Roles of EP4 Prostanoid Receptors in Cancer Malignancy Signaling2016
- Author(s)
  Fujino H.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 2 Pages: 149-155
- DOI
  10.1248/bpb.b15-00840
- NAID
  130005122367
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460091
[Journal Article] Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors.2015
- Author(s)
  Tanimoto J, Fujino H, Takahashi H, Murayama T.
- Journal Title
  
  FEBS Lett.
  
  Volume: 589 Issue: 6 Pages: 766-772
- DOI
  10.1016/j.febslet.2015.02.006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460091
[Journal Article] Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells.2015
- Author(s)
  Fujino H, Seira N, Kurata N, Araki Y, Nakamura H, Regan JW, Murayama T.
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 768 Pages: 149-159
- DOI
  10.1016/j.ejphar.2015.10.044
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460060, KAKENHI-PROJECT-25460091
[Journal Article] L-cysteine/d,L-homocysteine-regulated ileum motility via system L and B°,+ transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments.2015
- Author(s)
  Yamane S, Nomura R, Yanagihara M, Nakamura H, Fujino H, Matsumoto K, Horie S, Murayama T.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 764 Pages: 471-479
- DOI
  10.1016/j.ejphar.2015.07.042
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07968, KAKENHI-PROJECT-26460060, KAKENHI-PROJECT-24590118, KAKENHI-PROJECT-25460091, KAKENHI-PROJECT-25860395
[Journal Article] Cellular density-dependnet down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1α in HCA-7 human colon cancer cells.2015
- Author(s)
  Otake S, Yoshida K, Seira N, Sanchez CM, Regan JW, Fujino H, Murayama T.
- Journal Title
  
  Pharmacol Res Perspect.
  
  Volume: 3 Issue: 1
- DOI
  10.1002/prp2.83
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460091
[Journal Article] Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: roles of L-cysteine, cystathionine β-synthase, and K+ channels.2014
- Author(s)
  Yamane S, Kanno T, Nakamura H, Fujino H, Murayama T.
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 740 Pages: 112-120
- DOI
  10.1016/j.ejphar.2014.06.054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460091, KAKENHI-PROJECT-26460060, KAKENHI-PROJECT-26460093
[Journal Article] TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice2014
- Author(s)
  Hosoya T, Matsumoto K, Tashima K, Nakamura H, Fujino H, Murayama T, Horie S
- Journal Title
  
  Neurogastroenterol Motil
  
  Volume: 印刷中 Issue: 8 Pages: 1112-1121
- DOI
  10.1111/nmo.12368
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590118, KAKENHI-PROJECT-24790536, KAKENHI-PROJECT-25460091, KAKENHI-PROJECT-25860395, KAKENHI-PROJECT-26460060, KAKENHI-PROJECT-26460093
[Journal Article] A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells.2014
- Author(s)
  Oyama S, Fujino H, Yamazaki R, Okura I, Regan JW, Awata A, Arai T, Murayama T.
- Journal Title
  
  Arch. Biochem. Biophys.
  
  Volume: 541 Pages: 21-29
- DOI
  10.1016/j.abb.2013.10.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590106, KAKENHI-PROJECT-25460091, KAKENHI-PROJECT-26460093
[Journal Article] Bee venom phospholipase A2-induced phasic contractions in mouse rectum: Independent roles of eicosanoid and gap junction proteins and their loss in experimental colitis2013
- Author(s)
  Nomura R, Yanagihara M, Sato H, Matsumoto K, Tashima K, Horie S, Chen S, Fujino H, Ueno K, Murayama T
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 718 Issue: 1-3 Pages: 314-322
- DOI
  10.1016/j.ejphar.2013.08.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590118, KAKENHI-PROJECT-24790529, KAKENHI-PROJECT-24790536, KAKENHI-PROJECT-25460091
[Journal Article] Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to Gai and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells.2013
- Author(s)
  Yoshida K, Fujino H, Otake S, Seira N, Regan JW, Murayama T
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 718 Issue: 1-3 Pages: 408-417
- DOI
  10.1016/j.ejphar.2013.08.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460091
[Journal Article] Indomethacin antagonizes EP2 prostanoid receptor activation in LS174T human colon cancer cells2012
- Author(s)
  Ikawa Y, Fujino H, Otake S, Murayama T
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 680 Issue: 1-3 Pages: 16-21
- DOI
  10.1016/j.ejphar.2012.01.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590079, KAKENHI-PROJECT-23590106
[Journal Article] Novel anti-cancer effects of indomethacin: exploring the cyclooxygenase-inhibition-independent effects2011
- Author(s)
  Nakamura H, Yasufuku K, Makiyama T, Matsumoto I, Fujino H, Murayama T
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 137 Issue: 4 Pages: 177-181
- DOI
  10.1254/fpj.137.177
- NAID
  10029417534
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-22590079
[Journal Article] Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: a novel cyclooxygenase-inhibition-independent effect2011
- Author(s)
  Kato T, Fujino H, Oyama S, Kawashima T, Murayama T
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 82 Issue: 11 Pages: 1781-1791
- DOI
  10.1016/j.bcp.2011.07.096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590079
[Journal Article] Prostaglandin E_2 regulates cellular migration via induction of vascular endothelial growth factor receptor-1 in HCA-7 human colon cancer cells2011
- Author(s)
  Hiromichi Fujino, et al.
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 81 Pages: 379-387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590079
[Journal Article] Prostaglanidn E_2 regulates cellular migration via induction of vascular endothelial growth factor receptor-1 in HCA-7 human colon cancer cells2011
- Author(s)
  Fujino H, Toyomura K, Chen XB, Regan JW, Murayama T
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 81 Issue: 3 Pages: 379-387
- DOI
  10.1016/j.bcp.2010.11.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590079
[Journal Article] Decrease in uptake of arachidonic acid by indomethacin in LS174T human colon cancer cells: a novel cyclooxygenase-2-inhibition-independent effect2010
- Author(s)
  Orido T, Fujino H, Kawashima T, Murayama T
- Journal Title
  
  Arch Biochem Biophys
  
  Volume: 494 Issue: 1 Pages: 78-85
- DOI
  10.1016/j.abb.2009.11.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590079
[Journal Article] FP prostanoid receptor mediated induction of the expression of early growth response factor-l by activation of a Ras/Raf/MAPK signaling cascade.2008
- Author(s)
  Xu W, Chou CL, Sun H, Fujino H, Chen QM, Regan JW.
- Journal Title
  
  Mol. Pharmacol. 73
  
  Pages: 111-118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790045
[Journal Article] Indomethacin decreases EP2 prostanoid receptor expression in colon cancer cells.2007
- Author(s)
  Fujino H, Cken XB, Regan JW, Murayama T.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 359
  
  Pages: 568-573
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790045
[Journal Article] Vanadate-induced activation of cytosolic phospholipase A2alpha in L929 cells : Roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.2007
- Author(s)
  Taniguchi T, Shimizu M, Nakamura H, Hirabayashi T, Fujino H, Saito T, Murayama T
- Journal Title
  
  Biochem. Pharmacol. 73
  
  Pages: 854-862
- Data Source
  KAKENHI-PROJECT-18790045
[Journal Article] Vanadate-induced activation of cytosolic phospholipase A_2a in L929 cells: Roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.2007
- Author(s)
  Taniguchi T, Shimizu M, Nakamura H, Hirabayaski T, Fujino H, Saito T, Murayama T.
- Journal Title
  
  Biochem. Pharmacol. 73
  
  Pages: 854-862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790045
[Journal Article] EP4 prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein.2006
- Author(s)
  Fujino H, Regan JW
- Journal Title
  
  Mol. Pharmacol. 69
  
  Pages: 5-10
- Data Source
  KAKENHI-PROJECT-18790045
[Journal Article] Up-regulation of cytosolic phospholipase A2alpha expression by N, N-diethyldithiocarbamate in PC12 cells; involvement of reactive oxygen species and nitric oxide.2006
- Author(s)
  Akiyama N, Nabemoto M, Hatori Y, Nakamura H, Hirabayashi T, Fujino H, Saito T, Murayama T
- Journal Title
  
  Toxicol. Appl. Pharmacol 215
  
  Pages: 218-227
- Data Source
  KAKENHI-PROJECT-18790045
[Journal Article] Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2alpha.2006
- Author(s)
  Taniguchi T, Shimizu M, Nakamura H, Hirabayashi T, Fujino H, Murayama T
- Journal Title
  
  Eur. J. Pharmacol. 546
  
  Pages: 1-10
- Data Source
  KAKENHI-PROJECT-18790045
[Patent] インドール化合物、DPプロスタノイド受容体アンタゴニスト、それを用いた薬剤、及びDPプロスタノイド受容体アンタゴニストの使用2013
- Inventor(s)
  荒井孝義、藤野裕道、村山俊彦、大山聡美、阿波田篤子
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-192422
- Filing Date
  2013-09-17
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] Protein kinase Aが制御するEP4受容体シグナル伝達メカニズムの解明2024
- Author(s)
  柳川瞬矢、大西朗人、東山晃子、John W. Regan、福島圭穣、藤野裕道
- Organizer
  第144回　日本薬理学会近畿部会（高槻）
- Data Source
  KAKENHI-PROJECT-23K06149
[Presentation] EP4受容体の細胞内第３ループ領域に相互作用する因子の探索2024
- Author(s)
  東山晃子、大西朗人、柳川瞬矢、清良尚史、John W. Regan、大川内健人、傳田将也、福島圭穣、西野耕平、大髙章、小迫英尊、藤野裕道
- Organizer
  日本薬学会第144年会（横浜）
- Data Source
  KAKENHI-PROJECT-23K06149
[Presentation] プロスタグランジンD2代謝物のCRTH2受容体を介した機能的差異の解明2023
- Author(s)
  縣　美穂、蓮岡　奈苗、間下　雅士、福島　圭穣、藤野　裕道
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07084
[Presentation] P4プロスタノイド受容体シグナルの代謝機構への影響2023
- Author(s)
  中野　佑基、松本　聖加、大木元綾夏、染谷　早紀、福島　圭穣、藤野　裕道
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07084
[Presentation] PGJ2のヒトEP2プロスタノイド受容体を介したcAMP産生に対する影響2023
- Author(s)
  山下　真由、山本　瞳、篠原　万侑、福島　圭穣、菅波　晃子、田村　裕、藤野　裕道
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07084
[Presentation] EP4プロスタノイド受容体の１アミノ酸変異によるシグナル伝達変化2023
- Author(s)
  柳川瞬矢、大西朗人、東山晃子、John W. Regan、福島圭穣、藤野裕道
- Organizer
  生体機能と創薬シンポジウム2023（徳島）
- Data Source
  KAKENHI-PROJECT-23K06149
[Presentation] プロスタグランジンD2の代謝物はDPプロスタノイド受容体に対してバイアスアゴニストとして働く2022
- Author(s)
  妹尾　香奈穂、山本　瞳、遠藤　すず、Regan John W、福島　圭穣、藤野　裕道
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07084
[Presentation] プロスタノイドEP4受容体の１アミノ酸変異によるシグナル伝達プロファイル変化2022
- Author(s)
  大西　朗人、東山　晃子、柳川　瞬矢、清良　尚史、 Regan John W、大川内　健人、傳田　将也、福島　圭穣、大高　章、藤野　裕道
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07084
[Presentation] EP3プロスタノイド受容体サブタイプを高発現するヒト大腸がんクラスターの同定と性質評価2022
- Author(s)
  福島　圭穣、藤野　裕道
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07084
[Presentation] EP4プロスタノイド受容体とEP2プロスタノイド受容体2022
- Author(s)
  藤野　裕道
- Organizer
  第19回　生命科学研究会
- Data Source
  KAKENHI-PROJECT-20K07084
[Presentation] プロスタノイドEP2受容体とEP4受容体2022
- Author(s)
  福島　圭穣、藤野　裕道
- Organizer
  生体機能と創薬シンポジウム2022
- Data Source
  KAKENHI-PROJECT-20K07084
[Presentation] PGE2による結腸がん細胞内代謝変化の解析2021
- Author(s)
  松本　聖加、中野　佑基、高橋　弘喜、楠屋　陽子、村山　俊彦、福島　圭穣、藤野　裕道
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K07084
[Presentation] ヒト結腸がんHCA-7細胞においてインターロイキン4はEP4プロスタノイド受容体発現を抑制する2020
- Author(s)
  北川加奈, 濱口綾花, 間下雅士, Regan John W., 福島圭穣, 藤野裕道
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07084
[Presentation] PGE2代謝物 15-keto-PGE2はバイアスアゴニストとしてEP2およびEP4プロスタノイド受容体に作用する2020
- Author(s)
  遠藤すず, 妹尾香奈穂, 鷹野晴美, 荒木祐美, Regan John W., 福島圭穣, 藤野裕道
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] アラキドン酸による神経毒性作用を緩和する有効な生理活性脂質としてのプラズマローゲン種の同定2020
- Author(s)
  山際菜月, 小林春花, 福島圭穣, 岡林春花, 川村純, 琴浦聡, 藤野裕道
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] PGE2代謝物 15-keto-PGE2はバイアスアゴニストとしてEP2およびEP4プロスタノイド受容体に作用する2020
- Author(s)
  遠藤すず, 妹尾香奈穂, 鷹野晴美, 荒木祐美, Regan John W., 福島圭穣, 藤野裕道
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07084
[Presentation] inteinシステムを用いたプロスタノイドEP4受容体の局在解析を目指して2020
- Author(s)
  杉山学, 大西朗人, 森崎巧也, 重永章, 福島圭穣, 大高章, 藤野裕道
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] ヒト結腸がんHCA-7細胞においてインターロイキン4はEP4プロスタノイド受容体発現を抑制する2020
- Author(s)
  北川加奈, 濱口綾花, 間下雅士, Regan John W., 福島圭穣, 藤野裕道
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] 大腸の恒常性維持および癌発症とEP4受容体発現調節機構2019
- Author(s)
  藤野　裕道
- Organizer
  第18回生命科学研究会
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] 抗ヒスタミン薬による大腸がん誘発への有害事象の検討2019
- Author(s)
  増田雄大, 松本聖加, 松本礼, 福島圭穣, 藤野裕道
- Organizer
  第26回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] HIF-1α and c-Myc oppositely regulate human EP4 receptor promoter activity in human colon cancer HCA-7 cells.2019
- Author(s)
  山形一行, 清良尚史, 福島圭穣, 荒木裕美, 倉田直希, 柳澤直樹, 間下雅士, 中村浩之, REGAN W. John, 村山俊彦, 藤野裕道．
- Organizer
  第92会日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] 関節リウマチ治療薬を対象とした有害事象自発報告データベースFAERSを用いた感染症リスクの比較2018
- Author(s)
  福島　圭穣，市川　和哉，上野　崇宏，稲垣　孝行，宮川　泰宏，千﨑　康司，藤野　裕道，山田　清文
- Organizer
  第256回徳島医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] ヒト結腸がんHCA-7 細胞における酪酸によるEP4 受容体発現系への影響2018
- Author(s)
  渡嘉敷夏海, 倉田直希, 三竿顕也, 荒木祐美, 清良尚史, 山際菜月, 杉山学, 福島圭穣, REGAN John W, 村山俊彦, 藤野裕道
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] Hypoxia inducible factor-1alpha regulates human EP4 receptor expression by binding to specificity protein-1.2018
- Author(s)
  Naofumi Seira, Kazuyuki Yamagata, Keijo Fukushima, Yumi Araki, Naoki Kurata, Naoki Yanagisawa, Masato Mashimo, Hiroyuki Nakamura, John W. Regan, Toshihiko Murayama, Hiromichi Fujino.
- Organizer
  The 3rd Chiba University-Mahidol University Joint Symposium on Pharmaceutical Sciences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] ドラッグリポジショニング手法を用いた心肺蘇生後脳症治療薬の探索2018
- Author(s)
  新村貴博, 座間味義人, 石澤有紀, 今西正樹, 武智研志, 福島圭穣, 堀ノ内裕也, 池田康将, 藤野裕道, 土屋浩一郎, 玉置俊晃, 石澤啓介
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] Search for drugs that attenuate the anti tumor effect of bevacizumab using adverse event database.2018
- Author(s)
  Yoshito Zamami, Yuki Izawa-Ishizawa, Kenshi Takechi, Masaki Imanishi, Keijo Fukushima, Yuya Horinouchi, Yasumasa Ikeda, Hiromichi Fujino, Toshiaki Tamaki, Keisuke Ishizawa.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] PGE1 and E3 show lower efficacies than E2 to beta-catenin-mediated activity as biased ligands of EP4 prostanoid receptors.2018
- Author(s)
  Hiromichi Fujino, Yumi Araki, Akiko Suganami, Suzu Endo, Harumi Takano, Yuta Masuda, Keijo Fukushima, John W. Regan, Toshihiko Murayama, Yutaka Tamura.
- Organizer
  8th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] Renoprotective effects of edoxaban, a factor Xa inhibitor．2018
- Author(s)
  Yuya Horinouchi, Yasumasa Ikeda, Keijo Fukushima, Masaki Imanishi, Yuki Izawa-Ishizawa, Yoshito Zamami, Hiromichi Fujino, Keisuke Ishizawa, Koichiro Tsuchiya, Toshiaki Tamaki.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] EP4 prostanoid receptor expression by HIF-1a in human colon cancer HCA-7 cell line2017
- Author(s)
  Naofumi Seira, Hiromichi Fujino, Sho Otake, John W. Regan, Hiroki Takahashi, Toshihiko Murayama
- Organizer
  2nd World Congress of Cancer Research & Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] PGE1とPGE3のバイアス性と癌抑制機構の解明2017
- Author(s)
  荒木　祐美，菅波　晃子，遠藤すず，水口　博之，福島　圭穣，REGAN John W，村山　俊彦，田村　裕，藤野　裕道
- Organizer
  第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-17K08308
[Presentation] 新規インドール化合物のヒト結腸がんLS174T細胞への抗がん作用の探索2016
- Author(s)
  柳澤直樹、藤野裕道、和才真希子、荒井孝義、村山俊彦
- Organizer
  第８９回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] ヒト結腸癌HCA-7細胞において、HIF-1αはEP4受容体プロモーターHRE配列に結合し、受容体発現を制御する2016
- Author(s)
  清良尚史、藤野裕道、大竹翔、John W. Regan、村山俊彦
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] シクロスポリンAはヒト肺線維芽細胞および肺線維症モデルマウスにおいて線維化抑制作用を示す2016
- Author(s)
  山崎璃沙、藤田哲雄、柳原まどか、中村浩之、藤野裕道、粕谷善俊、村山俊彦
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] ヒト結腸癌HCA-7細胞を用いたヒトEP4プロスタノイド受容体による持続的な新規プロスタグランジンE2産生機構の解明2016
- Author(s)
  藤野裕道、清良尚史、倉田直希、荒木祐美、中村浩之、John W. Regan、村山俊彦
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] ヒトDPおよびEP2プロスタノイド受容体のcDNA配列変異の解析2016
- Author(s)
  谷本淳、藤野裕道、樋坂章博、高橋弘喜、村山俊彦
- Organizer
  第８９回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] Gi型Gタンパク質共役機構を中心としたヒトEP4プロスタノイド受容体細胞内C末端領域の役割の解明2015
- Author(s)
  倉田直希、藤野裕道、清良尚史、村山俊彦
- Organizer
  第133回日本薬理学会関東部会
- Place of Presentation
  柏の葉カンファレンスセンター（千葉県柏市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] ヒトEP4プロスタノイド受容体細胞内ループ3のシグナル伝達系への影響2015
- Author(s)
  清良尚史、藤野裕道、倉田直希、荒木祐美、村山俊彦
- Organizer
  第133回日本薬理学会関東部会
- Place of Presentation
  柏の葉カンファレンスセンター（千葉県柏市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] ニーマン・ピック病C型におけるセラミド代謝と細胞内コレステロール輸送との関わり2015
- Author(s)
  中村浩之、藤野裕道、村山俊彦
- Organizer
  第14回生命科学研究会
- Place of Presentation
  三浦市民ホール（神奈川県三浦市）
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] ヒト結腸癌HCA-7細胞におけるEP4受容体発現とhypoxia inducible factor-1α発現との関連性の解明2014
- Author(s)
  清良尚史、藤野裕道、大竹翔、吉田憲司、Regan JW、村山俊彦
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] 肺線維化への免疫抑制剤の影響2014
- Author(s)
  山崎璃沙、松澤康雄、川島辰男、柳原まどか、中村浩之、藤野裕道、村山俊彦
- Organizer
  第８７回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] ヒトEP4プロスタノイド受容体C末端領域機能の解明2014
- Author(s)
  清良尚史、藤野裕道、谷本淳、Regan JW、村山俊彦
- Organizer
  第１３１回日本薬理学会関東部会
- Place of Presentation
  横浜
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] 新規インドール化合物AWT-489はプロスタノイド受容体にアンタゴニストとして作用しCD55発現を抑制する2014
- Author(s)
  藤野裕道、大山聡美、山崎璃沙、大藏伊織、Regan JW、阿波田篤子、荒井孝義、村山俊彦
- Organizer
  第８７回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] ヒト結腸癌細胞HCA-7細胞においてEP4受容体はGiαタンパク質／上皮成長因子受容体を介してシクロオキシゲナーゼ－２発現を亢進する2013
- Author(s)
  藤野裕道、吉田憲司、中村浩之、Regan JW、村山俊彦
- Organizer
  第１２回生命科学研究会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] ヒト結腸癌HCA-7細胞においてEP4受容体はGαiタンパク質を介してcyclooxygenase-2発現を亢進する2013
- Author(s)
  藤野　裕道
- Organizer
  薬学会第１３３年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-22590079
[Presentation] 細胞内コレステロール輸送に関するスフィンゴミエリンの関与2013
- Author(s)
  鰐川雅裕、中村浩之、藤野裕道、村山俊彦
- Organizer
  第５７回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] ヒト結腸癌HCA-7細胞においてEP4受容体はGαiタンパク質を介してcyclooxygenase-2発現を亢進する2013
- Author(s)
  藤野裕道、吉田憲司、大竹翔、清良尚史、ReganJW、村山俊彦
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜(横浜)
- Data Source
  KAKENHI-PROJECT-22590079
[Presentation] TGF-β１による肺線維化への免疫抑制剤への影響2013
- Author(s)
  山崎璃沙、松澤康雄、川島辰男、柳原まどか、中村浩之、藤野裕道、村山俊彦
- Organizer
  第１２８回日本薬理学会関東支部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] 村より得られた知見を、今後さらに発展させ、例山俊彦ヒト結腸癌HCA-7細胞における低酸素えばインドメタシンをリードドラッグとするCOX阻害作用以外の作用を主作用としたドラッグデザインの開発に繋げて行けるのではないかと考えている。誘導因子-1αの役割の検討2013
- Author(s)
  大竹翔、藤野裕道、吉田憲司、ReganJW
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場(福岡)
- Data Source
  KAKENHI-PROJECT-22590079
[Presentation] 新規インドール化合物AWT-489のDPプロスタノイド受容体アンタゴニスト作用2013
- Author(s)
  大山聡美、藤野裕道、阿波田篤子、荒井孝義、村山俊彦
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場(福岡)
- Data Source
  KAKENHI-PROJECT-22590079
[Presentation] インドメタシンによるシクロオキシゲナーゼ阻害非依存的なプロスタグランジンE2刺激由来cAMP産生抑制作用メカニズムの解明2012
- Author(s)
  井川裕太、藤野裕道、村山俊彦
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-22590079
[Presentation] ヒト肺癌A549細胞株においてインドメタシンは上皮間葉転換を誘導し細胞形態変化および細胞移動を引き起こす2012
- Author(s)
  藤野裕道、加藤知子、大山聡美、川島辰男、村山俊彦
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-22590079
[Presentation] ヒト結腸癌HCA-7細胞においてプロスタグランジンE_2は1型血管内皮細胞増殖因子受容体発現を亢進することで細胞遊走を引き起こす2011
- Author(s)
  藤野裕道
- Organizer
  日本薬学会第131年会
- Place of Presentation
  ツインメッセ静岡(静岡)
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22590079
[Presentation] ヒト結腸癌HCA-7細胞においてプロスタグランジンE2はI型血管内皮細胞増殖因子受容体発現を亢進することで細胞遊走を引き起こす2011
- Author(s)
  藤野裕道、豊村香織、ChenX、ReganJW、村山俊彦
- Organizer
  日本薬学会第131会年会
- Place of Presentation
  ツインメッセ静岡(静岡)
- Data Source
  KAKENHI-PROJECT-22590079
[Presentation] インドメタシンの新たな抗癌機構の解明:シクロオキシゲナーゼ阻害非依存的作用の探究2010
- Author(s)
  藤野裕道、織戸貴史、中村浩之、川島辰男、村山俊彦
- Organizer
  第9回生命科学研究会
- Place of Presentation
  オークラホテルフロンティアつくば(筑波)
- Data Source
  KAKENHI-PROJECT-22590079
[Presentation] ヒト結腸癌細胞株のインドメタシン処理によるEP2受容体発現の減少2008
- Author(s)
  藤野裕道、Chen, Xiao-bo、Regan, John W.、村山俊彦
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-03-19
- Data Source
  KAKENHI-PROJECT-18790045
[Presentation] ヒトEP4プロスタノイド受容体細胞内ループ３のT cell Factor転写活性への影響
- Author(s)
  清良尚史、藤野裕道、倉田直希、Regan JW、村山俊彦
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] TGF-β1による肺線維化への免疫抑制剤の影響
- Author(s)
  山崎璃沙、松澤康雄、川島辰男、柳原まどか、中村浩之、藤野裕道、村山俊彦
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] がん増悪化情報伝達系へのプロスタノイド受容体の役割
- Author(s)
  藤野裕道
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] ヒト結腸癌HCA-7細胞の細胞密度依存的なEP4プロスタノイド受容体発現量の減少
- Author(s)
  藤野裕道、大竹翔、吉田憲司、清良尚史、Chistopher MS、Regan JW、村山俊彦
- Organizer
  第８８回日本薬理学会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] ラクトシルセラミドによる細胞質型ホスホリパーゼA2α活性化機構の解明
- Author(s)
  中村浩之、森山友太、藤野裕道、村山俊彦
- Organizer
  第１３回　生命科学研究会
- Place of Presentation
  札幌
- Year and Date
  2014-06-20 – 2014-06-21
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts.
- Author(s)
  Yamazaki R, Kawashima T, Matsuzawa Y, Otake S, Yamaura E, Nakamura H, Fujino H, Murayama T.
- Organizer
  54th International Conference on the Bioscience of Lipids 2014
- Place of Presentation
  Aberdeen, Scotland, UK
- Year and Date
  2014-06-23 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] プロスタグランジンD2はEP2プロスタノイド受容体を介してcAMP非依存的にT cell factorシグナルを活性化する
- Author(s)
  大蔵伊織、藤野裕道、清良尚史、Christopher MS、Regan JW、村山俊彦
- Organizer
  第８８回日本薬理学会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-25460091
[Presentation] Evans Blue処置による摘出腸管標本への影響：giant contractionsの発生
- Author(s)
  菅野敏生、陳爍楠、藤野裕道、村山俊彦
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25460091

1. MURAYAMA Toshihiko (90174317)

# of Collaborated Projects: 2 results

# of Collaborated Products: 38 results
2. 大高章 (20201973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. IKEDA Yasumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. NAKAMURA Hiroyukii

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. TAMURA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. SUGANAMI Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 石澤有紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 今西正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 堀江俊治

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 福島圭穣

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 間下雅士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujino Hiromichi 藤野 裕道

FUJINO Hiromichi 藤野 裕道

藤野 裕道 フジノ ヒロミチ

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プロスタノイドEP4受容体の恒常的活性による細胞増殖速度調整メカニズムの解明Principal Investigator

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Explore the irreversible check point from normal to malignant transformation of the cells by changing in the balance of the expression levels of the EP prostanoid receptor subtypes.Principal Investigator

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Exploring the mechanism of EP4 prostanoid receptor-evoked colorectal cancer development during the collapse of homeostasis and its ameliorating effects by substances of type 2 innate immune systemPrincipal Investigator

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Mechanisms of colon cancer malignancy regulation by two endogenous prostanoid receptorsPrincipal Investigator

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Exploring the novel cycloocygenase-inhibition-independent effects of indomethacinPrincipal Investigator

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プロスタグランジンE2およびそのEP4受容体情報伝達系のガン化への関与の解明Principal Investigator

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[Book] 薬系薬理学書 （分担）２章 薬物作用の基本（２．１ 薬の作用様式（薬理作用），２．２ 細胞情報伝達系と受容体）2018

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[Book] Assessment of constitutive activity in E-type prostanoid receptors2010

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[Book] Methods in Enzymology Voliume 4842010

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[Journal Article] Down-regulation of the expression of cyclooxygenase-2 and prostaglandin E2 by interleukin-4 is mediated via a reduction in the expression of prostanoid EP4 receptors in HCA-7 human colon cancer cells2022

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[Journal Article] The Biased Activities of Prostanoids and Their Receptors: Review and Beyond2022

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[Journal Article] The Gαs‐protein‐mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors2022

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[Journal Article] Foreword2022

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Fujino Hiromichi 藤野裕道

FUJINO Hiromichi 藤野裕道

藤野裕道フジノヒロミチ

[Book] 薬系薬理学書（分担）２章　薬物作用の基本（２．１　薬の作用様式（薬理作用），２．２　細胞情報伝達系と受容体）2018