KOBAYASHI Tsuyoshi 小林剛

Researcher Number	40402052
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 特任講師
Affiliation (based on the past Project Information) *help	2007 – 2009: 山梨大学, 医学部附属病院, 医員
Review Section/Research Field	Except Principal Investigator Circulatory organs internal medicine
Keywords	Except Principal Investigator 好中球 / 脂質メディエーター / 炎症 / 分泌型ホスホリパーゼA / ノックアウトマウス / 心血管病 / 心筋梗塞

A study of role of phospholipase A2 in pathogenosis of cardiovascular diseases and development of new drug for cardiovascular diseases
- Principal Investigator
  
  KUGIYAMA Kiyotaka
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Yamanashi

All 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Mice lacking the glutamate-cysteine ligase modifier subunit are susceptible to myocardial ischaemia-reperfusion injury.2010
- Author(s)
  Kobayashi T, Watanabe Y, Saito Y, Fujioka D, Nakamura T, Obata JE, Kitta Y, Yano T, Kawabata K, Watanabe K, Mishina H, Ito S, Kugiyama K.
- Journal Title
  
  Cardiovasc Res. 85,4
  
  Pages: 785-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390209
[Journal Article] Inhibition of secretory hospholipase A2 activity attenuates lipopolysaccharide-induced acute lung injury in a mouse model.2010
- Author(s)
  Sato R, Yamaga S, Watanabe K, Hishiyama S, Kawabata K, Kobayashi T, Fujioka D, Saito Y, Yano T, Watanabe K, Watanabe Y, Ishihara H, Kugiyama K.
- Journal Title
  
  Exp Lung Res. 36,4
  
  Pages: 191-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390209
[Journal Article] Mice lacking the glutamate-cysteine ligase modifier subunit are susceptible to myocardial ischaemia-reperfusion injury.2010
- Author(s)
  Kobayashi T.
- Journal Title
  
  Cardiovasc Res 35
  
  Pages: 785-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390209
[Journal Article] High serum levels of remnant lipoproteins predict ischemic stroke in patients with metabolic syndrome and mild carotid atherosclerosis.2009
- Author(s)
  Nakamura T, Obata JE, Takano H, Kawabata K, Sano K, Kobayashi T, Fujioka D, Saito Y, Yano T, Kugiyama K.
- Journal Title
  
  Atherosclerosis. 202,1
  
  Pages: 234-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390209
[Journal Article] Rapid improvement of carotid plaque echogenicity within 1 month of pioglitazone treatment in patients with acute coronary syndrome.2009
- Author(s)
  Hirano M, Nakamura T, Kitta Y, Yano T, Kobayashi T, Sano K, Fujioka D, Saito Y, Kodama Y, Kawabata K, Nakamura K, Obata JE, Kugiyama K.
- Journal Title
  
  Atherosclerosis. 203,2
  
  Pages: 483-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390209
[Journal Article] Persistent impairment of endothelial vasomotor function has a negative impact on outcome in patients with coronary artery disease.2009
- Author(s)
  Kitta Y, Obata JE, Nakamura T, Hirano M, Kodama Y, Fujioka D, Saito Y, Kawabata K, Sano K, Kobayashi T, Yano T, Nakamura K, Kugiyama K.
- Journal Title
  
  J Am Coll Cardiol. 53,4
  
  Pages: 323-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390209
[Journal Article] Reduction in myocardial ischemia/reperfusion injury in group X secretory phospholipase A2-deficient mice.2008
- Author(s)
  Fujioka D, Saito Y, Kobayashi T, Yano T, Tezuka H, Ishimoto Y, Suzuki N, Yokota Y, Nakamura T, Obata JE, Kanazawa M, Kawabata K, Hanasaki K, Kugiyama K.
- Journal Title
  
  Circulation. 117,23
  
  Pages: 2977-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390209
[Journal Article] Sirolimus-eluting stent implantation aggravates endothelial vasomotor dysfunction in the infarct-related coronary artery in patients with acute myocardial infarction.2007
- Author(s)
  Obata JE, Kitta Y, Takano H, Kodama Y, Nakamura T, Mende A, Kawabata K, Saitoh Y, Fujioka D, Kobayashi T, Yano T, Kugiyama K.
- Journal Title
  
  J Am Coll Cardiol. 50,14
  
  Pages: 1305-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390209
[Presentation] Reduction in Myocardial Ischemia-reperfusion Injury in Group V Secretory Phospholipase A2-deficient Mice.2009
- Author(s)
  Toshiaki Yano; Keni-chi Kawabata; Yukio Saito; Tsuyoshi Kobayashi; Ryota Sato; Kazuhiro Watanabe; Yosuke Watanabe; Hideto Mishina; Jun-ei Obata; Kiyotaka Kugiyama
- Organizer
  American Heart Association Scientific Sessions.
- Place of Presentation
  Orlando.
- Data Source
  KAKENHI-PROJECT-19390209
[Presentation] Reduction in Myocardial Ischemia-reperfusion Injury in Group IV Cytosolic Phospholipase A2-deficient Mice Partly Due to Inhibition of TNFα-mediated Pathway to Cell Injury.2009
- Author(s)
  Yukio Saito; Yousuke Watanabe; Hideto Mishina; Kazuhiro Watanabe; Toshiaki Yano; Tsuyoshi Kobayashi; Jun-ei Obata; Ken-ichi Kawabata; Takao Shimizu; Kiyotaka Kugiyama
- Organizer
  American Heart Association Scientific Sessions.
- Place of Presentation
  Orlando.
- Data Source
  KAKENHI-PROJECT-19390209
[Presentation] Inhibition of Secretory Phospholipase A2 Activity Attenuates Acute Cardiogenic Pulmonary Congestion Induced by Isoproterenol Infusion in Mice with Post-Myocardial Infarction.2008
- Author(s)
  Kenichi Kawabata, Tsuyoshi Kobayashi, Yousuke Watanabe, Kazuhiro Watanabe, Toshiaki Yano, Ryota Sato, Yukio Saito, Kazuto Nakamura, Kiyotaka Kugiyama
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-19390209
[Presentation] Group X Secretory Phospholipase A2 has a Critical Role in Neutrophils Activation and Myocardial Ischemia-reperfusion Injury in Mice.2007
- Author(s)
  Daisuke Fujioka, Kenichi Kawabata, Yoshikazu Ishimoto, Noriko Suzuki, Kohji Hansaki, Ryota Sato, Toshiaki Yano, Tsuyoshi Kobayashi, Yukio Saito, Masaki Kanazawa, Kiyotaka Kugiyama
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  Orlando
- Data Source
  KAKENHI-PROJECT-19390209

1. KUGIYAMA Kiyotaka (00225129)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. KAWABATA Kenichi (30345706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
3. SAITO Yukio (50377511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
4. TEZUKA Hideo (70155456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. FUJIOKA Daisuke (70377513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results

KOBAYASHI Tsuyoshi 小林 剛

Research Projects

Research Products

Co-Researchers

A study of role of phospholipase A2 in pathogenosis of cardiovascular diseases and development of new drug for cardiovascular diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mice lacking the glutamate-cysteine ligase modifier subunit are susceptible to myocardial ischaemia-reperfusion injury.2010

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of secretory hospholipase A2 activity attenuates lipopolysaccharide-induced acute lung injury in a mouse model.2010

Author(s)

Journal Title

Data Source

[Journal Article] Mice lacking the glutamate-cysteine ligase modifier subunit are susceptible to myocardial ischaemia-reperfusion injury.2010

Author(s)

Journal Title

Data Source

[Journal Article] High serum levels of remnant lipoproteins predict ischemic stroke in patients with metabolic syndrome and mild carotid atherosclerosis.2009

Author(s)

Journal Title

Data Source

[Journal Article] Rapid improvement of carotid plaque echogenicity within 1 month of pioglitazone treatment in patients with acute coronary syndrome.2009

Author(s)

Journal Title

Data Source

[Journal Article] Persistent impairment of endothelial vasomotor function has a negative impact on outcome in patients with coronary artery disease.2009

Author(s)

Journal Title

Data Source

[Journal Article] Reduction in myocardial ischemia/reperfusion injury in group X secretory phospholipase A2-deficient mice.2008

Author(s)

Journal Title

Data Source

[Journal Article] Sirolimus-eluting stent implantation aggravates endothelial vasomotor dysfunction in the infarct-related coronary artery in patients with acute myocardial infarction.2007

Author(s)

Journal Title

Data Source

[Presentation] Reduction in Myocardial Ischemia-reperfusion Injury in Group V Secretory Phospholipase A2-deficient Mice.2009

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Reduction in Myocardial Ischemia-reperfusion Injury in Group IV Cytosolic Phospholipase A2-deficient Mice Partly Due to Inhibition of TNFα-mediated Pathway to Cell Injury.2009

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Inhibition of Secretory Phospholipase A2 Activity Attenuates Acute Cardiogenic Pulmonary Congestion Induced by Isoproterenol Infusion in Mice with Post-Myocardial Infarction.2008

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Group X Secretory Phospholipase A2 has a Critical Role in Neutrophils Activation and Myocardial Ischemia-reperfusion Injury in Mice.2007

Author(s)

Organizer

Place of Presentation

Data Source

KOBAYASHI Tsuyoshi 小林剛