Aoki Koji 青木耕史

… Alternative Names

AOKI Koji 青木耕史

青木耕史アオキコウジ

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Researcher Number	40402862
Other IDs
Affiliation (Current)	2025: 福井大学, 学術研究院医学系部門, 教授
Affiliation (based on the past Project Information) *help	2025: 福井大学, 学術研究院医学系部門, 教授 2018 – 2023: 福井大学, 学術研究院医学系部門, 教授 2016: 福井大学, 学術研究院医学系部門, 教授 2013 – 2015: 福井大学, 医学部, 教授 2012: 京都大学, 大学院・医学研究科, 助教 … More 2012: 福井大学, テニュアトラック推進本部, 助教 2011: 京都大学, 工学研究科, 助教 2010 – 2011: 京都大学, 医学研究科, 助教 2005: 京都大学, 医学研究科, 研究員(COE) Less
Review Section/Research Field	Principal Investigator Tumor biology / Basic Section 50010:Tumor biology-related / Basic Section 49030:Experimental pathology-related / Basic Section 48040:Medical biochemistry-related / Experimental pathology Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 49010:Pathological biochemistry-related / General medical chemistry / Experimental pathology / Pathological medical chemistry
Keywords	Principal Investigator 大腸癌 / CDX2 / ATG7 / オートファジー / 癌幹細胞 / 細胞生存 / 細胞増殖 / PAF1 / 転写機構 / PAF1複合体 … More / β-cateninタンパク質 / がん幹細胞性 / 大腸がん / ホメオボックス蛋白質 / 腸炎 / 腸管粘膜 / 腸管上皮細胞 / クローン病 / 炎症性腸疾患 / 細胞周期 / 細胞死 / 増殖 / 活性酸素 / ROS / CDX1 / 幹細胞性 / 悪性化 / 転写 / 癌抑制遺伝子 … More Except Principal Investigator 大腸癌 / GEF / 化学療法薬 / BET阻害薬 / 転写調節CDK阻害薬 / 癌幹細胞性 / 抗がん薬 / CDK阻害薬 / 転写CDK / がん幹細胞性 / 大腸がん / 腫瘍学 / LGR5 / 癌幹細胞 / CDX2 / CDX1 / ATG7 / オートファジー / Transcriptional regulation / Chromatin immunoprecipitation / Target genes / Gastrointestinal tract / Homeobox / Transcription factors / Cancer / クロマチン免疫沈降法 / シグナル伝達 / 転写調節 / クロマチン免疫沈降 / 標的遺伝子 / 消化管 / ホメオボックス / 転写因子 / 癌 / 消化器癌 / Notch / 未分化骨髄球 / マウスモデル / 消化器がん / 転移 / 分子腫瘍学 Less

大腸癌での高頻度変異p53-R175Hによるがん幹細胞性の誘導メカニズムの解析Principal Investigator
- Principal Investigator
  
  青木耕史
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  University of Fukui
Control of colon cancer stemness by PAF1 complexPrincipal Investigator
- Principal Investigator
  
  青木耕史
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  University of Fukui
Suppression of colorectal cancer stemness by transcription-related CDK inhibitors
- Principal Investigator
  
  Hori Kazuya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  University of Fukui
Intestinal mucosal barrier by homeobox protein CDX2Principal Investigator
- Principal Investigator
  
  Aoki Koji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  University of Fukui
Suppression of colon cancer stemness by caudal-related homeobox transcription factors CDX1 and CDX2
- Principal Investigator
  
  Kazuya Hori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  University of Fukui
Activation control mechanism of autophagy essential enzyme ATG7
- Principal Investigator
  
  NAKAYA MAKO
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  University of Fukui
The role of CDX1 in malignant progression of intestinal tumorigenesisPrincipal Investigator
- Principal Investigator
  
  AOKI Koji
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  University of Fukui
Block of proliferation and survival of colon cancer cells by intestine-specific homeoprotein CDX2Principal Investigator
- Principal Investigator
  
  Aoki Koji
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Tumor biology
- Research Institution
  University of Fukui
Analysis of the molecular mechanisms by which CDX2 supresses colon caner cell proliferationPrincipal Investigator
- Principal Investigator
  
  AOKI Koji
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyoto University
StudiesonMetastasisofDigestiveCancersUsingMouseModels
- Principal Investigator
  
  TAKETO Makoto
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto University
Molecular mechanism of involvement of homeobox transcription factors Cdx2 and Cdxl in intestinal tumors
- Principal Investigator
  
  AOKI Masahiro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyoto University

[Book] Chronic inflammation: Elucidation and Control of the mechanisms2016
- Author(s)
  Aoki K* and Sugai M
- Total Pages
  14
- Publisher
  Springer Press
- Data Source
  KAKENHI-PROJECT-24680091
[Journal Article] Assessing the Safety of Mechanically Fibrillated Cellulose Nanofibers (fib-CNF) via Toxicity Tests on Mice: Single Intratracheal Administration and 28 Days’ Oral Intake2024
- Author(s)
  Yamashita Yoshihiro、Tokunaga Akinori、Aoki Koji、Ishizuka Tamotsu、Uematsu Hideyuki、Sakamoto Hiroaki、Fujita Satoshi、Tanoue Shuichi
- Journal Title
  
  Toxics
  
  Volume: 12 Issue: 2 Pages: 121-121
- DOI
  10.3390/toxics12020121
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06946, KAKENHI-PROJECT-21K07216
[Journal Article] NELF and PAF1C complexes are core transcriptional machineries controlling colon cancer stemness2024
- Author(s)
  Aoki Koji、Nitta Akari、Igarashi Ayumi
- Journal Title
  
  Oncogene
  
  Volume: 43 Issue: 8 Pages: 566-577
- DOI
  10.1038/s41388-023-02930-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06946, KAKENHI-PROJECT-21K07216
[Journal Article] Blocking LC3 lipidation and ATG12 conjugation reactions by ATG7 mutant protein containing C572S2019
- Author(s)
  Nitta A, Hori K, Tanida I, Igarashi A, Deyama Y, Ueno T, Kominami E, Sugai M, Aoki K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 508(2) Issue: 2 Pages: 521-526
- DOI
  10.1016/j.bbrc.2018.11.158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06928, KAKENHI-PROJECT-18K06955, KAKENHI-PROJECT-18K19423, KAKENHI-PROJECT-16H05138, KAKENHI-PROJECT-15K12749, KAKENHI-PROJECT-16K15232
[Journal Article] Mitochondrial function provides instructive signals for activation-induced B cell fates2015
- Author(s)
  Kyoung-Jin Jang, Hiroto Mano, Koji Aoki, Tatsunari Hayashi, Yukiko Nambu, Eri Hara, Katsu Takahashi, Katsuhiko Itoh, Shigeru Taketani, Kazuhiko Igarashi, Akira Shimizu and Manabu Sugai
- Journal Title
  
  Nature Commun
  
  Volume: 6 Issue: 1 Pages: 6750-6750
- DOI
  10.1038/ncomms7750
- NAID
  120005595832
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25463081, KAKENHI-PROJECT-25460352, KAKENHI-PROJECT-25293069, KAKENHI-PROJECT-24680091
[Journal Article] Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation. Carcinogenesis.2015
- Author(s)
  Hatano Y, Semi K, Hashimoto K, Lee MS, Hirata A, Tomita H, Kuno T, Takamatsu M, Aoki K, Taketo MM, Kim YJ, Hara A, Yamada Y.
- Journal Title
  
  Carcinogenesis
  
  Volume: 36 Issue: 7 Pages: 719-29
- DOI
  10.1093/carcin/bgv060
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04721, KAKENHI-PROJECT-26830069, KAKENHI-PROJECT-24680091
[Journal Article] In situ differentiation of CD8ααT cells from CD4 T cells in peripheral lymphoid tissues2012
- Author(s)
  Nambu Y, Hayashi T, Jang KJ, Aoki K, Mano H, Nakano K, Osato M, Takahashi K, Itoh K, Teramukai S, Komori T, Fujita J, Ito Y, Shimizu A, Sugai M
- Journal Title
  
  Scientific Reports
  
  Volume: 2 Pages: 642-642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650619
[Journal Article] In situ differentiation of CD8αα T cells from CD4 T cells in peripheral lymphoid tissues2012
- Author(s)
  Nambu Y., Hayashi T., Jang KJ, Aoki K., Mano H., Nakano K., Osato M., Takabashi K., Itoh K., Teramukai S., Komon T., Fujita J., Ito Y., Shimizu
- Journal Title
  
  Scientific Reports
  
  Volume: 2 Issue: 1 Pages: 930-930
- DOI
  10.1038/srep00642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J05804, KAKENHI-PROJECT-21390077, KAKENHI-PROJECT-22592213, KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24390073, KAKENHI-PROJECT-24592446, KAKENHI-PROJECT-24650619, KAKENHI-PROJECT-24659147, KAKENHI-PROJECT-24659148, KAKENHI-PROJECT-24680091
[Journal Article] Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation2011
- Author(s)
  Sugai M, Aoki K, Osato M, Nambu Y, Ito K, Taketo MM, Shimizu A.
- Journal Title
  
  J Immunol
  
  Volume: 186 Pages: 6515-6520
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] JNK signaling promotes intestinal tumorigenesis through mTOR complex1 activation in ApcΔ 716 mice2011
- Author(s)
  Fujishita T, Aoki M, and Taketo MM.
- Journal Title
  
  Gatroenterology
  
  Volume: 140(in press)
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] Suppression of colon cancer metastasis byAes through inhibition of Notch signaling2011
- Author(s)
  Sonoshita M, Aoki M, Fuwa H, Aoki K, Hosogi H, Sakai Y, Hashida H, Takabayashi A, Sasaki M, Robine S, Itoh K, Yoshioka K, Kakizaki F, Kitamura T, Oshima M, andTaketo MM
- Journal Title
  
  Cancer Cell
  
  Volume: Vol.19(1) Pages: 125-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790380
[Journal Article] JNK signaling promotes intestinal tumorigenesis through mTOR compleXlactivation in ApcΔ716 mice2011
- Author(s)
  Fujishita T, Aoki M, Taketo MM
- Journal Title
  
  Gastroenterology
  
  Volume: 140 Issue: 5 Pages: 1566-1563
- DOI
  10.1053/j.gastro.2011.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229005, KAKENHI-PROJECT-23300349
[Journal Article] JNK signaling promotes intestinal tumorigenesis through mTOR complex1 activation in Apc^<716> mice.2011
- Author(s)
  Fujishita T, Aoki M, Taketo MM.
- Journal Title
  
  Gastroenterology
  
  Volume: 140(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip12011
- Author(s)
  Aoki K, Kakizaki F, Sakashita H, Manabe T, Aoki M, and Taketo MM.
- Journal Title
  
  Cancer Res
  
  Volume: 71 Pages: 593-602
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] Suppression of colonic polyposis by homeoprotein CDX2 through its non transcriptional function that stabilizes p27^<Kip1>.2011
- Author(s)
  Aoki K, Kakizaki F, Sakashita H, Manabe T, Aoki M, Taketo MM.
- Journal Title
  
  Cancer Res.
  
  Volume: 71 Pages: 593-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling.2011
- Author(s)
  Sonoshita M, Aoki M, Fuwa H, Aoki K, et al.
- Journal Title
  
  Cancer Cell
  
  Volume: 19(1) Pages: 125-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790380
[Journal Article] Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation.2011
- Author(s)
  Sugai, M., Aoki, K., Osato, T., Nambu, Y., Ito, K., Taketo, M. M., Ito, Y. and Shimizu, A.
- Journal Title
  
  J. Immunol,
  
  Volume: 186 Issue: 11 Pages: 6515-6520
- DOI
  10.4049/jimmunol.1001671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390077, KAKENHI-PROJECT-22790380
[Journal Article] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling2011
- Author(s)
  Sonoshita M, Aoki M, Fuwa H, Aoki K, Hosogi H, Sakai Y, Hashida H, Takabayashi A, Sasaki M, Robine S, Itoh K, Yoshioka K, Kakizaki F, Kitamura K, Oshima M, and Taketo MM.
- Journal Title
  
  Cancer Cell
  
  Volume: 19 Pages: 125-137
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] Suppression of colonic polyposis byhomeoprotein CDX2 through its no transcriptional function that stabilizes p27Kip12011
- Author(s)
  Aoki K, Kakizaki F, Sakashita H, Manabe T, Aoki M, and Taketo MM
- Journal Title
  
  Cancer Research
  
  Volume: Vol.71(2) Pages: 593-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790380
[Journal Article] Runx3 is reuired for full activation of regulatory T cells to preventcolitis-associated tumor formation2011
- Author(s)
  Aoki K, Sugai M, Osato M, Nambu Y, Ito K, Taketo MM and Shimizu A.
- Journal Title
  
  Journal of Immunology
  
  Volume: Vol.186(11) Pages: 6515-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790380
[Journal Article] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling.2011
- Author(s)
  Sonoshita M, Aoki M, Fuwa H, Aoki K, Hosogi H, Sakai Y, Hashida H, Takabayashi A, Sasaki M, Robine S, Itoh K, Yoshioka K, Kakizaki F, Kitamura K, Oshima M, Taketo MM.
- Journal Title
  
  Cancer Cell
  
  Volume: 19 Pages: 125-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1.2011
- Author(s)
  Aoki K, et al.
- Journal Title
  
  Cancer Research
  
  Volume: 71(2) Pages: 593-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790380
[Journal Article] Inactivation of CCR1 suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model.2010
- Author(s)
  Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka-Kondoh S, Aoki M, Taketo MM.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 107 Pages: 13063-13068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain2010
- Author(s)
  Deguchi A, Miyoshi H, Kojima Y, Okawa K, Aoki M, and Taketo MM.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Pages: 18283-18290
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] Inactivation of CCR1 suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model2010
- Author(s)
  Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka-Kondoh S, Aoki M, and Taketo MM.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 107 Pages: 13063-13068
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain.2010
- Author(s)
  Deguchi A, Miyoshi H, Kojima Y, Okawa K, Aoki M, Taketo MM
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 285 Pages: 18283-18290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] CDX Transcription Factors Positively Regulate Expression of Solute Carrier Family 5, Member 8 in the Colonic Epithelium.2010
- Author(s)
  Kakizaki F, Aoki K, Miyoshi H, Carrasco N, Aoki M and Taketo MM.
- Journal Title
  
  Gastroenterology
  
  Volume: 138 Pages: 627-635
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] CDX transcription factors positivelyregulate expression of solute carrier family 5, member 8 in the colonicepithelium2010
- Author(s)
  Kakizaki F, Aoki K, Miyoshi H, Carrasco N, Aoki M, and Taketo MM
- Journal Title
  
  Gastroenterology
  
  Volume: Vol.138(2) Pages: 627-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790380
[Journal Article] The role of mTORC1 pathway in intestinal tumorigenesis2009
- Author(s)
  Fujishita T, Aoki M, Taketo MM.
- Journal Title
  
  Cell Cycle
  
  Volume: 8 Pages: 3684-3687
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] Reduced Level of Smoothened Suppresses Intestinal Tumorigenesis by Down-Regulation of Wnt Signaling2009
- Author(s)
  Arimura S, Matsunaga A, Kitamura T, Aoki K, Aoki M, Taketo MM.
- Journal Title
  
  Gastroenterology
  
  Volume: 137 Pages: 629-638
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice2009
- Author(s)
  Miyoshi H, Deguchi A, Nakau M, Kojima Y, Mori A, Oshima M, Aoki M, Taketo MM.
- Journal Title
  
  Cancer Sci.
  
  Volume: 100 Pages: 2046-53
- Data Source
  KAKENHI-PROJECT-21229005
[Journal Article] Chromosomal instability by beta-catenin/TCF transcription in Apcor beta-catenin mutant cells.2007
- Author(s)
  Aoki, K, et. al.
- Journal Title
  
  Oncogene 26
  
  Pages: 3511-3520
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390113
[Journal Article] Chromosomal instability by beta-catenin/TCF transcription in Apc or beta-catenin mutant cells.2007
- Author(s)
  Aoki, K, et. al.
- Journal Title
  
  Oncogene 26
  
  Pages: 3511-3520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390113
[Journal Article] Chromosomal instability by beta-catenin/TCF transcription in Ape or beta-catenin mutant cells2007
- Author(s)
  Aoki, K., et. al.
- Journal Title
  
  Oncogene 26
  
  Pages: 3511-3520
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390113
[Journal Article] Chromosomal instability by beta-catenin/TCF transcription in Apcor beta-catenin mutant cells.2006
- Author(s)
  Aoki, K. et al.
- Journal Title
  
  Oncogene (e-pub)
- Data Source
  KAKENHI-PROJECT-17390113
[Patent] ATG7変異体を用いたオートファジーの抑制方法2012
- Inventor(s)
  青木耕史、谷田似誠
- Industrial Property Rights Holder
  青木耕史、谷田似誠
- Industrial Property Rights Type
  特許
- Filing Date
  2012-12-21
- Acquisition Date
  2016-12-09
- Data Source
  KAKENHI-PROJECT-24680091
[Patent] ATG7変異体を用いたオートファジーの抑制方法2012
- Inventor(s)
  青木耕史、谷田以誠
- Industrial Property Rights Holder
  青木耕史、谷田以誠
- Filing Date
  2012-12-21
- Data Source
  KAKENHI-PROJECT-24650619
[Patent] ＡＴＧ７変異株を用いたオートファジーの制御方法2012
- Inventor(s)
  青木耕史、谷田以誠
- Industrial Property Rights Holder
  福井大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-12-21
- Data Source
  KAKENHI-PROJECT-24650619
[Patent] ATG7変異株を用いたオートファジーの制御方法2012
- Inventor(s)
  青木耕史、谷田以誠
- Industrial Property Rights Holder
  福井大学
- Industrial Property Number
  2012-280082
- Filing Date
  2012-12-21
- Data Source
  KAKENHI-PROJECT-24680091
[Presentation] A Transcriptional Mechanism that Controls Colon Cancer Stemness2022
- Author(s)
  青木耕史
- Organizer
  第81回日本学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06946
[Presentation] Mechanism that controls colon cancer stemness, via PAF1 complex through a competition between b-catenin and CDX22020
- Author(s)
  Aoki K
- Organizer
  第79回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06928
[Presentation] Mechanism that controls colon cancer stemness, via PAF1 complex through a competition between β-catenin and CDX1/22020
- Author(s)
  Koji Aoki
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06955
[Presentation] Suppression of intestinal cancer stemness and malignant progression by intestine-specific homeoproteins CDX1 and CDX22018
- Author(s)
  Kazuya Hori, Mako Nakaya, Takanori Goi, Akio Yamaguchi, Shunichiro Iemura, Tohru Natsume, Makoto M. Taketo, Manabu Sugai, Koji Aoki
- Organizer
  Looking to the future of Developmental Cell Biology Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-18K06955
[Presentation] Suppression of intestinal cancer stemness and malignant progression by intestine-specific homeoproteins CDX1 and CDX22016
- Author(s)
  Aoki K
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-24680091
[Presentation] nhanced intestinal mucosal barrier function by homeoprotein CDX2 through autophagy activation2016
- Author(s)
  Nakaya M and Aoki K
- Organizer
  第45回日本免疫学会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-24680091
[Presentation] Enhanced intestinal mucosal barrier function by homeoprotein CDX2 through autophagy activation2016
- Author(s)
  Aoki K., (1/12) et al.
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-06
- Data Source
  KAKENHI-PROJECT-24680091
[Presentation] Blocking intestinal cancer stemness and malignant progression by intestine-specific homeoproteins CDX1 and CDX22016
- Author(s)
  Aoki K and Hori K
- Organizer
  第3回北陸エピジェネティクス
- Place of Presentation
  AOSSA（福井県福井市）
- Year and Date
  2016-11-21
- Data Source
  KAKENHI-PROJECT-24680091
[Presentation] Suppression of intestinal cancer stemness and malignant progression by intestine-specific homeoproteins CDX1 and CDX22016
- Author(s)
  Hori K and Aoki K (9/9) et al.
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-24680091
[Presentation] Roles of intestine-specific homeoprotein CDX2 in the intestinal epithelial barrier2013
- Author(s)
  Aoki K, Iemura S, Okawa K, Tanida I, Kobayashi T, Mimuro H, Takahito S, Sasakawa C, Natume T, Sugai M, Taketo MM
- Organizer
  ST-CREST International Symposium, Frontiers in Immunology and Inflammation : From Molecules to Disease
- Place of Presentation
  Tokyo
- Year and Date
  2013-02-13
- Data Source
  KAKENHI-PROJECT-24650619
[Presentation] INK signaling promotes intestinal tumorigenesis through mTORC1 pathway activation in ApeΔ716 mice2012
- Author(s)
  藤下晃章, 青木正博, 武藤誠
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都国際会館
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-21229005
[Presentation] JNKシグナル伝達経路はmTORC1の活性化を介してApe変異マウスの腸管腫瘍形成を促進する2011
- Author(s)
  青木正博, 藤下晃章、武藤誠
- Organizer
  第15回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテル日航東京
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-21229005
[Presentation] JNK promotes intestinal tumor formation in mutant mice through activation of mTOR couplex 12011
- Author(s)
  青木正博, 藤下晃章、武藤誠
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋コングレスセンター
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21229005
[Presentation] The roles of mTORC1 in the intestinal adenocarcinoma2011
- Author(s)
  藤下晃章、青木正博, 武藤誠
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋コングレスセンター
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21229005
[Presentation] 消化管腫瘍形成におけるSmoothened及びmTORC1の役割2009
- Author(s)
  青木正博
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜、日本
- Data Source
  KAKENHI-PROJECT-21229005
[Presentation] Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells.2006
- Author(s)
  Aoki, K, et. al.
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390113
[Presentation] Chromosomal instability by beta-catenin/TCF transcription in Apc or beta-catenin mutant cells2006
- Author(s)
  Aoki, K., et. al.
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390113
[Presentation] Roles of intestine-specific homeoprotein CDX2 in the intestinal epithelial barrier
- Author(s)
  Koji Aoki, Shun-ichiro Iemura, Katsuya Okawa, Isei Tanida, Taira Kobayashi, Hitomi Mimuro, Sanada Takahito, Chihiro Sasakawa, Tohru Natume, Makoto M Taketo and Manabu Sugai
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24680091
[Presentation] Roles of intestine-specific homeoprotein CDX2 in the intestinal epithelial barrier
- Author(s)
  Koji Aoki and Mako Nakaya
- Organizer
  日本免疫学会
- Place of Presentation
  石川県立音楽堂交流ホール
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24680091
[Presentation] Suppression of intestinal cancer stemness and malignant progression by intestine-specific homeoproteins CDX1 and CDX2
- Author(s)
  Koji Aoki, Kazuya Hori, Takanori Goi, Akio Yamaguchi, Makoto M. Taketo and Manabu Sugai
- Organizer
  日本癌学会シンポジウム　がん幹細胞・微小環境・分子標的
- Place of Presentation
  国立京都国際会館
- Year and Date
  2015-01-21 – 2015-01-22
- Data Source
  KAKENHI-PROJECT-24680091

1. Kazuya Hori (50749059)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. AOKI Masahiro (60362464)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
3. TAKETO Makoto (70281714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
4. KITAMURA Takanori (10378622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. SONOSHITA Masahiro (80511857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. FUJISHITA Teruaki (50511870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
7. NAKAYA MAKO (60538552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HASHIMOTO Syuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 菅井学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 高橋克

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 清水章

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 青木一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山田泰広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 井本正哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Aoki Koji 青木 耕史

AOKI Koji 青木 耕史

青木 耕史 アオキ コウジ

Research Projects

Research Products

Co-Researchers

大腸癌での高頻度変異p53-R175Hによるがん幹細胞性の誘導メカニズムの解析Principal Investigator

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Control of colon cancer stemness by PAF1 complexPrincipal Investigator

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Suppression of colorectal cancer stemness by transcription-related CDK inhibitors

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Intestinal mucosal barrier by homeobox protein CDX2Principal Investigator

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Suppression of colon cancer stemness by caudal-related homeobox transcription factors CDX1 and CDX2

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Activation control mechanism of autophagy essential enzyme ATG7

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The role of CDX1 in malignant progression of intestinal tumorigenesisPrincipal Investigator

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Block of proliferation and survival of colon cancer cells by intestine-specific homeoprotein CDX2Principal Investigator

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Analysis of the molecular mechanisms by which CDX2 supresses colon caner cell proliferationPrincipal Investigator

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StudiesonMetastasisofDigestiveCancersUsingMouseModels

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Molecular mechanism of involvement of homeobox transcription factors Cdx2 and Cdxl in intestinal tumors

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[Book] Chronic inflammation: Elucidation and Control of the mechanisms2016

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[Journal Article] Assessing the Safety of Mechanically Fibrillated Cellulose Nanofibers (fib-CNF) via Toxicity Tests on Mice: Single Intratracheal Administration and 28 Days’ Oral Intake2024

Author(s)

Journal Title

Aoki Koji 青木耕史

AOKI Koji 青木耕史

青木耕史アオキコウジ