• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

CHIHARA Yoshitomo  千原 良友

ORCIDConnect your ORCID iD *help
… Alternative Names

千原 良友  チハラ ヨシトモ

Less
Researcher Number 40405395
Affiliation (based on the past Project Information) *help 2017 – 2019: 奈良県立医科大学, 医学部附属病院, 研究員
2014 – 2016: 奈良県立医科大学, 医学部, 研究員
2010 – 2015: 奈良県立医科大学, 医学部, 講師
2007: 奈良県立医大, 医学部附属病院, 研究員
2006: 奈良県立医科大学, 医学部, 博士研究員
Review Section/Research Field
Principal Investigator
Urology
Except Principal Investigator
Human pathology / Urology
Keywords
Principal Investigator
エピジェネティクス / 尿中剥離細胞 / DNAメチル化 / エピジェネテイクス / がん幹細胞 / メチル化 / 癌幹細胞 / 診断マーカー / 膀胱癌 / エピゲネティクス … More / 診断 / 膀胱がん / 腫瘍学 / DNAチップ / ホモ欠失 / 染色体欠失 / マッピング解析 / 表在性膀胱癌 … More
Except Principal Investigator
がん微小環境 / ミトコンドリア / DNAメチル化 / がん幹細胞 / ピロリ菌感染 / 胃癌 / 抗クローディン4抗体 / 抗がん剤増感 / tight junction / 抗体療法 / claudin / ヘテロスフェア / 癌転移 / 細胞間相互作用 / 間葉系幹細胞 / 副作用 / Claudinシグナル / 化学療法増感 / 抗Claudin抗体 / 薬剤耐性 / ナノチューブ / タンネリング / 抗がん剤副作用 / 抗がん剤耐性 / 抗がん剤併用療法 / clostridium perfringens / CPE / Hippo / YAP / クローディン4 / 幹細胞性 / 上皮間葉移行 / 細菌 / 分子標的薬 / 抗癌剤 / タイトジャンクション / クローディン / 免疫応答 / 血管新生因子 / 上皮間葉転換 / 膀胱上皮内癌 / 腫瘍微小環境 / 鉄 / コラーゲン / BCG / アミノレブリン酸 / 免疫細胞 / 膀胱がん / 制御性T細胞 / CD56 / Collagen / CXCL1 / CLDN / 膀胱内注入療法 / 上皮内癌 / 膀胱癌 / 幹細胞可塑性 / 分化がん細胞 / 増殖性がん幹細胞 / 冬眠性がん幹細胞 / 多光子励起蛍光顕微鏡 / がん細胞分化・脱分化 / キネティクス / 幹細胞分化 / ベンゾイソフラノン化合物 / DNAメチル化 / 細胞外マトリクス / ラットPCK / ベンゾイソフラノン誘導体 / 細胞マトリックス / PCKラット / 多発性嚢胞腎 / アセチル化ヒストン / リジン残基 / H4ヒストン / p16 / エピジェネティクス / カルボキシメチル化 / ヒストン・リジン修飾 / トリメチル化 / H3ヒストンK27 / リジンカルボキシメチル化 / 遺伝子発現 / ヒストン / 糖化最終産物 / 糖化 / ヒストン・アセチル化 / リジン・カルボキシメチル化 / 糖尿病 / エライジン酸 / リノール酸 / HMGB1 / TGFβ / カロリー制限 / 癌幹細胞 / 脂肪酸 / 肝転移 / 大腸癌 / 骨髄間葉系幹細胞 Less
  • Research Projects

    (9 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (15 People)
  •  Application of anti-claudin-4 antibody to anti-cancer therapy

    • Principal Investigator
      Kuniyasu Hiroki
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Nara Medical University
  •  Molecular biological profile of carcinoma in situ of urinary bladder as predictive and prognostic markers

    • Principal Investigator
      FUJIMOTO KIYOHIDE
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Nara Medical University
  •  Aberrant DNA methylation of cancer stem cell genes correlate with bladder carcinogenesisPrincipal Investigator

    • Principal Investigator
      Chihara Yoshitomo
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Nara Medical University
  •  In vivo observation of stemness acquisition in differentiated cancer cells

    • Principal Investigator
      KUNIYASU Hiroki
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Human pathology
    • Research Institution
      Nara Medical University
  •  Novel epigenetic change by histone lysine carboxymethylation

    • Principal Investigator
      Fujii Kiyomu
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Nara Medical University
  •  Basic studies of therapeutic modality for polycystic kidney disease explored by epigenetic modification of cellular matrix-adhesion proteins

    • Principal Investigator
      ISHIBASHI MIchio
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Nara Medical University
  •  Targeting of mesenchymal stem cell associated with colorectal cancer liver metastasis

    • Principal Investigator
      OHMORI Hitoshi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Nara Medical University
  •  Diagnostic markers of urothelial cancer based on DNA methylation analysisPrincipal Investigator

    • Principal Investigator
      CHIHARA Yoshitomo
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Urology
    • Research Institution
      Nara Medical University
  •  表在性膀胱癌における全Genome領域のAllelotypingとホモ欠失の解析Principal Investigator

    • Principal Investigator
      千原 良友
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Urology
    • Research Institution
      Nara Medical University

All 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

  • [Journal Article] Diagnostic and prognostic role of urinary collagens in primary human bladder cancer.2017

    • Author(s)
      Miyake M, Morizawa Y, Hori S, Tatsumi Y, Onishi S, Owari T, Iida K, Onishi K, Gotoh D, Nakai Y, Anai S, Chihara Y, Torimoto K, Aoki K, Tanaka N, Shimada K, Konishi N, Fujimoto K.
    • Journal Title

      Cancer Sci.

      Volume: 108 Issue: 11 Pages: 2221-2228

    • DOI

      10.1111/cas.13384

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10605, KAKENHI-PROJECT-16K20159
  • [Journal Article] Expression of ferrochelatase has a strong correlation in protoporphyrin IX accumulation with photodynamic detection of bladder cancer2016

    • Author(s)
      Yasushi Nakai, Yoshihiro Tatsumi, Makito Miyake, Satoshi Anai, Masaomi Kuwada, Sayuri Onishi, Yoshitomo Chihara, Nobumichi Tanaka, Yoshihiko Hirao, Kiyohide Fujimoto
    • Journal Title

      Photodiagnosis and Photodynamic Therapy

      Volume: 13 Pages: 225-232

    • DOI

      10.1016/j.pdpdt.2015.07.174

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10605
  • [Journal Article] Pro-chemotherapeutic effects of antibody against extracellular domain of claudin-4 in bladder cancer2015

    • Author(s)
      Masaomi Kuwada, Yoshitomo Chihara, Yi Luo, Xiangru Li, Yukiko Nishiguchi, Rina Fujiwara, Takamistu Sasaki, Kiyomu Fujii, Hitoshi Ohmori, Kiyohide Fujimoto, Masuo Kondoh, Hiroki Kuniyasu
    • Journal Title

      Cancer Letters

      Volume: 369 Issue: 1 Pages: 212-221

    • DOI

      10.1016/j.canlet.2015.08.019

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10605, KAKENHI-PROJECT-26460424, KAKENHI-PROJECT-24590450
  • [Journal Article] Expression of MAS1 in breast cancer.2015

    • Author(s)
      Luo Y, Tanabe E, Kitayoshi M, Nishiguchi Y, Fujiwara R, Matsushima S, Sasaki T, Sasahira T, Chihara Y, Fujii K, Ohmori H, Kuniyasu H
    • Journal Title

      Cancer Sci

      Volume: 106 Issue: 9 Pages: 1240-1248

    • DOI

      10.1111/cas.12719

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26460424, KAKENHI-PROJECT-24590450
  • [Journal Article] Cancer usurps skeletal muscle as an energy repository2014

    • Author(s)
      Luo Y, Ohmori H, et al
    • Journal Title

      Cancer Res

      Volume: 74 Issue: 1 Pages: 330-340

    • DOI

      10.1158/0008-5472.can-13-1052

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23590430, KAKENHI-PROJECT-25670177, KAKENHI-PROJECT-26460424
  • [Journal Article] Novel missense mutation in the FH gene in familial renal cell cancer patients lacking cutaneous leiomyomas2014

    • Author(s)
      Kuwada M, Kuniyasu H, et al
    • Journal Title

      BMC Res Note

      Volume: 7 Issue: 1 Pages: 203-203

    • DOI

      10.1186/1756-0500-7-203

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670177
  • [Journal Article] High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy.2013

    • Author(s)
      Luo Y, Chihara Y, Fujimoto K, Sasahira T, Kuwada M, Fujiwara R, Fujii K, Ohmori H, Kuniyasu H
    • Journal Title

      Eur J Cancer

      Volume: 49 Issue: 3 Pages: 741-751

    • DOI

      10.1016/j.ejca.2012.09.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590430, KAKENHI-PROJECT-23659188, KAKENHI-PROJECT-24590450, KAKENHI-PROJECT-25670177
  • [Journal Article] Diagnostic markers of urothelial cancer based on DNA methylation analysis.2013

    • Author(s)
      Chihara Y, Kuniyasu H, et al.
    • Journal Title

      BMC Cancer

      Volume: 13 Issue: 1 Pages: 275-275

    • DOI

      10.1186/1471-2407-13-275

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670177
  • [Journal Article] High matrix metalloproteinase-to-E-cadherin ratio measured by bicolor fluorescent in situ hybridization is associated with lymphangiogenesis and lymph node metastasis in prostate cancer2012

    • Author(s)
      Luo Y, Ohmori H, Fujii K, Chihara Y, Maruyama S, Kuniyasu H
    • Journal Title

      Urol Oncol-Semin Ori

      Volume: 30 Issue: 3 Pages: 306-313

    • DOI

      10.1016/j.urolonc.2010.05.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590430, KAKENHI-PROJECT-23659188, KAKENHI-PROJECT-24590450
  • [Journal Article] Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet2012

    • Author(s)
      Shimomoto T, Luo Y, Ohmori H, Chihara Y, Sasahira T, Fujii K, Kuniyasu H
    • Journal Title

      J Gastroenterol

      Volume: 47 Issue: 10 Pages: 1073-83

    • DOI

      10.1007/s00535-012-0572-5

    • NAID

      10031122095

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590430, KAKENHI-PROJECT-23659188, KAKENHI-PROJECT-24590450
  • [Journal Article] Diabetes-associated angiotensin activation enhances liver metastasis of colon cancer.2012

    • Author(s)
      Shimomoto T, Ohmori H, Luo Y, Chihara Y, Denda A, Sasahira T, Tatsumoto N, Fujii K, Kuniyasu H
    • Journal Title

      Clin Exp Metast

      Volume: 29 Issue: 8 Pages: 915-925

    • DOI

      10.1007/s10585-012-9480-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590430, KAKENHI-PROJECT-23659188, KAKENHI-PROJECT-24590450
  • [Presentation] 抗claudin-4抗体の併用による抗体分子治療薬の効果促進2016

    • Author(s)
      國安弘基、羅 奕、桑田真臣、佐々木隆光、千原良友、藤井 澄、大森 斉
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2016-05-12
    • Data Source
      KAKENHI-PROJECT-16H05164
  • [Presentation] Enhancement of antitumoral effect of molecular-targeting antibody by anti-claudin-4 antibody.2016

    • Author(s)
      Kuniyasu H, Luo Y, Sasaki T, Chihara Y, Fujiwara R, Nishiguchi Y, Hashimoto Y, Kondo M
    • Organizer
      76th Annual Meeting of Japanese Association for Cancer
    • Place of Presentation
      横浜市
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16H05164
  • [Presentation] Pro-chemotherapeutic effects of antibody against extracellular domain of claudin-4 in bladder cancer.2016

    • Author(s)
      Kuwada M, Chihara Y, Luo Y, Sasaki T, Fujimoto K, Kondoh M, Kuniyasu H
    • Organizer
      Annual Meeting of American Association for Cancer Research 2016
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-04-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05164
  • [Presentation] Cancer stem-like cells and epithelial mesenchymal transition is responsible for failure in bacillus Calmette-Guérin therapy for primary carcinoma in situ.2015

    • Author(s)
      Kuwada M, Chihara Y, Miyake M, Anai S, Tanaka N, Kuniyasu H, Fujimoto K
    • Organizer
      Annual Meeting of American Urology Association 2015
    • Place of Presentation
      New Orleans
    • Year and Date
      2015-05-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24590450
  • [Presentation] Claudine-4 細胞外ドメインを認識するモノクロナル抗体による膀胱癌の分子標的療法の検討2015

    • Author(s)
      桑田真臣、羅 奕、李 相儒、西口由希子、藤原里奈、佐々木隆光、千原良友、藤本清秀、近藤昌夫、國安弘基
    • Organizer
      第24回日本がん転移学会学術集会・総会
    • Place of Presentation
      シティプラザ大阪
    • Year and Date
      2015-07-23
    • Data Source
      KAKENHI-PROJECT-15K10605
  • [Presentation] アンギオテンシン系および血糖調節を標的とする大腸癌肝転移の抑制2012

    • Author(s)
      大森 斉、羅 奕、川田元清、千原良友、國安弘基
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590430
  • [Presentation] トランス脂肪酸によるEGFR活性化2012

    • Author(s)
      羅 奕、藤井 澄、森若優希子、千原良友、國安弘基
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      大津
    • Data Source
      KAKENHI-PROJECT-24590450
  • [Presentation] 大腸がんにおける宿主代謝への影響2012

    • Author(s)
      國安弘基、羅 奕、栗原 都、笹平智則、千原良友、藤井 澄、大森 斉
    • Organizer
      第27 回発癌病理研究会、シンポジウム5
    • Place of Presentation
      修善寺
    • Data Source
      KAKENHI-PROJECT-24590450
  • [Presentation] Angiotensin in colorectal cancer metastasis2012

    • Author(s)
      Luo Y, Chihara Y, Ohmori H, Fujii K, Yoshikawa M, Kuwata M, Fujimoto K, Hirao Y, Kitadai Y, Kuniyasu H
    • Organizer
      103rd Annual Meeting of American Association for Cancer Research
    • Place of Presentation
      Chicago
    • Data Source
      KAKENHI-PROJECT-24590450
  • [Presentation] Role of myxomatous stroma to mesenchymal stem cells in colorectal cancer2012

    • Author(s)
      Kuniyasu H, Fujimoto R, Luo Y, Fujii K, Ohmori H, Maruyama H, Sasahira T, Chihara Y
    • Organizer
      71st Annual Meeting of Japanese Cancer Association
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23590430
  • [Presentation] 大腸がんにおける宿主代謝への影響2012

    • Author(s)
      國安弘基、羅 奕、栗原 都、笹平智則、千原良友、藤井 澄、大森 斉
    • Organizer
      第27 回発癌病理研究会、シンポジウム5
    • Place of Presentation
      修善寺
    • Data Source
      KAKENHI-PROJECT-23590430
  • [Presentation] トランス脂肪酸によるEGFRのトランス活性化2012

    • Author(s)
      藤井 澄、羅 奕、桑田真臣、森若優希子、千原良友、藤本清秀、國安弘基
    • Organizer
      第21回日本がん転移学会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-24590450
  • [Presentation] Effect of fatty acids oral intake on tumor stem cells2012

    • Author(s)
      Ohmori H, Katada N, Shima K, Luo Y, Kurihara M, Chihara Y, Kuniyasu H
    • Organizer
      71st Annual Meeting of Japanese Cancer Association
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23590430
  • [Presentation] 尿中DNAメチル化異常を指標とした尿路上皮がん診断2011

    • Author(s)
      千原良友、金井弥栄、藤本博行
    • Organizer
      日本泌尿器科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-04-21
    • Data Source
      KAKENHI-PROJECT-22791508
  • [Presentation] Diagnostic indicator of urothelial cancer based on DNA methylation analysis2011

    • Author(s)
      Chihara Y, Kuniyasu H, Liang G, et al.
    • Organizer
      American Urological Association Annual meeting
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2011-05-15
    • Data Source
      KAKENHI-PROJECT-22791508
  • [Presentation] Diagnostic indicator of urothelial cancer based on DNA methylation analysis2011

    • Author(s)
      Chihara Yoshitomo
    • Organizer
      American Urological Assosiation Annual Meeting
    • Place of Presentation
      Washington DC
    • Year and Date
      2011-05-15
    • Data Source
      KAKENHI-PROJECT-22791508
  • [Presentation] 高血糖の大腸癌肝転移に及ぼす影響2011

    • Author(s)
      大森 斉、羅 奕、藤井 澄、下元貴澄、千原良友、國安弘基
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-23590430
  • [Presentation] Two molecular pathways to bladder cancer involve opposing roles of DNA methylation2010

    • Author(s)
      千原良友
    • Organizer
      日本癌学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-22791508
  • [Presentation] Two molecular pathways to bladder cancer involve opposing roles of DNA methylation2010

    • Author(s)
      千原良友
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-22791508
  • [Presentation] Claudin-4を標的とする治療の可能性

    • Author(s)
      國安弘基、羅 奕、千原良友、桑田真臣、北吉美沙穂、田邊絵里子、佐々木隆光、大森 斉、近藤昌夫
    • Organizer
      第29回発癌病理研究会
    • Place of Presentation
      いわき市
    • Year and Date
      2014-09-01 – 2014-09-03
    • Data Source
      KAKENHI-PROJECT-25670177
  • 1.  KUNIYASU Hiroki (00253055)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  KITADAI Yasuhiko (10304437)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  OHMORI Hitoshi (80213875)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 12 results
  • 4.  FUJII Kiyomu (60284189)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 5.  SASSAKI Takamitsu (00382284)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 6.  FUJIMOTO KIYOHIDE (50264867)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 7.  SASAHIRA Tomonori (90405374)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 8.  ISHIBASHI MIchio (40107032)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  HIGASHIHARA Eiji (00092312)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  NAGAO Shizuko (20183527)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KOJIMA Naoto (90420413)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  FUJIMOTO Yoshio (90192731)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TAKAKI Miyako (00033358)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  三宅 牧人 (80601400)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 15.  国安 弘基
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 21 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi