SASAKI Nobunari 佐々木信成

… Alternative Names

佐々木信成ササキノブナリ

Sasaki Nobunari 佐々木信成

SASAKI Nobuari 佐々木信成

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Researcher Number	40415170
Other IDs
Affiliation (Current)	2025: 公益財団法人がん研究会, がん研究所細胞生物部, 特任研究員
Affiliation (based on the past Project Information) *help	2023: 公益財団法人がん研究会, がん研究所細胞生物部, 特任研究員 2016: 金沢大学, がん進展制御研究所, 研究員 2013 – 2014: 金沢大学, がん進展制御研究所, 博士研究員 2005: 独立行政法人理化学研究所, 神経細胞極性研究チーム, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology Except Principal Investigator Tumor biology / Biological Sciences
Keywords	Principal Investigator 肺がん / 腫瘍免疫 / Sotorasib / MAVS / dsRNA / cancer stem cell / mevalonate pathway / cholesterol / ROS / がん幹細胞 … More / retinoblastoma / コレステロールエステル / 癌幹細胞 / 前立腺がん / RB / 細胞内ROS / 悪性進展 / メバロン酸経路 / コレステロール … More Except Principal Investigator グルタミン / 糖代謝 / コレステロール / がん幹細胞 / 代謝 / がん / がん抑制遺伝子 / PGAM / 脂質代謝 / 解糖系 / RB / がん代謝 / 細胞間シグナル / 顆粒細胞 / プルキンエ細胞 / 樹状突起 / DNER Less

LKB1/KEAP1変異に伴う腫瘍免疫制御を介したソトラシブ耐性機序の解明Principal Investigator
- Principal Investigator
  
  佐々木信成
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Regulation of metabolism by RB tumor suppressor gene
- Principal Investigator
  
  Takahashi Chiaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
The metabolic function of RB in controlling mevalonate (MVA) pathway regulates tumor progressionPrincipal Investigator
- Principal Investigator
  
  SASAKI Nobuari
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
細胞間シグナルによる中枢神経系ニューロン・グリア突起の分岐パターン制御機構
- Principal Investigator
  
  見学美根子
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research

All 2024 2023 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 『代謝変化とエピジェテックス制御』「RBがん抑制遺伝子産物による細胞未分化性制御」2016
- Author(s)
  河野晋、北嶋俊輔、佐々木信成、髙橋智聡.
- Total Pages
  7
- Publisher
  生化学
- Data Source
  KAKENHI-PROJECT-26290037
[Journal Article] <i>TREX1</i> Inactivation Unleashes Cancer Cell STING-Interferon Signaling and Promotes Antitumor Immunity2024
- Author(s)
  Tani Tetsuo、Mathsyaraja Haritha、Campisi Marco、Li Ze-Hua、Haratani Koji、Fahey Caroline G.、Ota Keiichi、Mahadevan Navin R.、Shi Yingxiao、Saito Shin、Mizuno Kei、Thai Tran C.、Sasaki Nobunari、Homme Mizuki、・・・・・・・・Liu David、Uppaluri Ravindra、Kitajima Shunsuke、Cain Jennifer、Barbie David A, et al
- Journal Title
  
  Cancer Discovery
  
  Volume: 14 Issue: 5 Pages: 752-765
- DOI
  10.1158/2159-8290.cd-23-0700
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06684, KAKENHI-PROJECT-23K27444
[Journal Article] Targeting the loss of <scp>cGAS</scp>/<scp>STING</scp> signaling in cancer2023
- Author(s)
  Sasaki Nobunari、Homme Mizuki、Kitajima Shunsuke
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 10 Pages: 3806-3815
- DOI
  10.1111/cas.15913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06684, KAKENHI-PROJECT-22K19467, KAKENHI-PROJECT-23K27444
[Journal Article] The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity.2017
- Author(s)
  Kitajima S, Yoshida A, Susumu K, Li F, Suzuki S, Nagatani N, Nishimoto Y, Sasaki N, Hayato M, Wan Y, Thai T C, Okahashi N, Matsuda F, Shimizu H, Nishiuchi T, Suzuki Y, Tominaga K, Gotoh N, Suzuki M, Ewen M E, Barbie D A, Hirose O, Tanaka T and Takahashi C
- Journal Title
  
  Oncogene
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290037
[Journal Article] RB tumor suppressor functions shared by stem cell and cancer cell strategies.2016
- Author(s)
  Kohno S, Kitajima S, Sasaki N and Takahashi C.
- Journal Title
  
  World J Stem Cells
  
  Volume: 8 Issue: 4 Pages: 170-184
- DOI
  10.4252/wjsc.v8.i4.170
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01487, KAKENHI-PROJECT-26290037, KAKENHI-PROJECT-15K18404
[Journal Article] Undifferentiated State Induced by Rb-P53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts2015
- Author(s)
  Kitajima S, Kohno S, Kondoh A, Sasaki N, Nishimoto Y, Li F, Mohammed MS, Muranaka H, Nagatani N, Suzuki M, Kido Y, Takahashi C
- Journal Title
  
  STEM CELLS
  
  Volume: - Issue: 5 Pages: 1657-1669
- DOI
  10.1002/stem.1971
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25830076, KAKENHI-PROJECT-25830077, KAKENHI-PROJECT-26640070, KAKENHI-PROJECT-15K18404, KAKENHI-PUBLICLY-15H01487, KAKENHI-PROJECT-26290037
[Journal Article] ATM mediates pRB function to control DNMT1 protein stability and DNA methylation.2013
- Author(s)
  Shamma A, Suzuki M, Hayashi N, Kobayashi M, Sasaki N, Nishiuchi T, Doki Y, Okamoto T, Kohno S, Muranaka H, Kitajima S, Yamamoto K, Takahashi C
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 33 Issue: 16 Pages: 3113-3124
- DOI
  10.1128/mcb.01597-12
- NAID
  120005312327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25340028, KAKENHI-PROJECT-25830076, KAKENHI-PROJECT-25830077
[Presentation] The metabolic function of RB in controlling mevalonate (MVA) pathway regulates tumor progression2015
- Author(s)
  Sasaki N, Kitajima S, Muranaka H, Shamma A, Kohno S, Takahashi C
- Organizer
  Keystone Symposia
- Place of Presentation
  Vancouver・Canada・Fairmont Hotel
- Year and Date
  2015-01-16
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] The metabolic function of RB in controlling mevalonate (MVA) pathway and tumor progression.2014
- Author(s)
  Sasaki N, Muranaka H, Kitajima S, Kohno S, Shamma A and Takahashi C
- Organizer
  第37回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] RBによるメバロン酸経路を介したがん悪性進展制御機構.2014
- Author(s)
  佐々木信成, 村中勇人, 北嶋俊輔, 河野晋, Shamma A, 髙橋智聡
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] The metabolic function of RB in controlling mevalonate (MVA) pathway and cancer cells2014
- Author(s)
  Nobunari Sasaki, Chiaki Takahashi
- Organizer
  International Symposium on Tumor Biology in Kanazawa & Symposium on Drug Discovery in Academics
- Place of Presentation
  金沢エクセルホテル東急
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] RBの中心代謝制御機能2014
- Author(s)
  河野晋, 北嶋俊輔, 吉田晶代, 鈴木佐和子, 田中知明, 佐々木信成, 村中勇人, 髙橋智聡
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] Role of RB tumor suppressor gene in central carbon metabolism2014
- Author(s)
  Susumu Kohno, Shunsuke Kitajima, Sawako Suzuki, Tomoaki Tanaka, Nobuyuki Okahashi, Fumio Matsuda, Hiroshi Shimizu, Nobunari Sasaki, Hayato Muranaka, Chiaki Takahashi
- Organizer
  International Symposium on Tumor Biology in Kanazawa & Symposium on Drug Discovery in Academics
- Place of Presentation
  金沢エクセルホテル東急
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] がん抑制遺伝子RBによるSREBP-1の制御とがんにおける役割の解析2014
- Author(s)
  村中勇人, 北嶋俊輔, 佐々木信成, 河野晋, 吉田晶代, 丹下正一朗, 鈴木健之, 林昭夫, 多田秀昭, Shamma A, 髙橋智聡
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] RB不活性化によって誘導されるがん幹細胞様未分化状態におけるPgam2の役割2014
- Author(s)
  河野晋, 北嶋俊輔, 佐々木信成, 村中勇人, 鈴木佐和子, 田中知明, 岡橋伸幸, 松田史生, 清水浩, 髙橋智聡
- Organizer
  第2回がんと代謝研究会
- Place of Presentation
  東京都・葛飾区・東京理科大学
- Year and Date
  2014-07-16
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] RB controls lipid metabolism in cancer cells2014
- Author(s)
  Hayato Muranaka, Shunsuke Kitajima, Nobunari Sasaki, Susumu Kohno, Awad Shamma, Chiaki Takahashi
- Organizer
  International Symposium on Tumor Biology in Kanazawa & Symposium on Drug Discovery in Academics
- Place of Presentation
  金沢エクセルホテル東急
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] The role of RB tumor suppressor gene in central carbon metabolism2013
- Author(s)
  Susumu Kohno, Shunsuke Kitajima, Nobunari Sasaki, Hayato Muranaka, Chiaki Takahashi
- Organizer
  Third International Rb Meeting
- Place of Presentation
  Monterey, CA. USA
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] RBの中心炭素代謝調節機能2013
- Author(s)
  河野晋、北嶋俊輔、佐々木信成、村中勇人、鈴木佐和子、田中知明、岡橋信幸、松田史生、清水浩、高橋智聡
- Organizer
  第1回がんと代謝研究会
- Place of Presentation
  鶴岡慶應義塾大学先端生命科学研究所
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] がん抑制遺伝子RBの代謝調節機能2013
- Author(s)
  河野晋、北嶋俊輔、佐々木信成、村中勇人、高橋智聡
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] The pRB-ATM-DNMT1 nexus is a novel pathway to the epigenetic control of cancer progression2013
- Author(s)
  Awad Shamma, Naoyuki Hayashi, Nobunari Sasaki, Chiaki Takahashi
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] RBによるメバロン酸経路の制御とがん幹細胞における役割2013
- Author(s)
  佐々木信成、高橋智聡
- Organizer
  平成25年度がん若手ワークショップ
- Place of Presentation
  蓼科蓼科グランドホテル滝の湯
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] The metabolic function of RB tumor suppressor gene2013
- Author(s)
  Susumu Kohno, Shunsuke Kitajima, Nobunari Sasaki, Hayato Muranaka, Chiaki Takahashi
- Organizer
  American Association for Cancer Research Annual Meeting 2013
- Place of Presentation
  Washington, DC. USA
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] RBによるメバロン酸経路を介したがん悪性進展制御機構
- Author(s)
  佐々木信成, 村中勇人, 北嶋俊輔, 河野晋, Shamma A, 髙橋智聡
- Organizer
  平成26年度がん若手研究者ワークショップ
- Place of Presentation
  蓼科　蓼科グランドホテル滝の湯
- Year and Date
  2014-09-03 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] RBによるメバロン酸経路を介したがん悪性進展制御機構
- Author(s)
  佐々木信成, 村中勇人, 北嶋俊輔, 河野晋, Shamma A, 髙橋智聡
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜　パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] がん抑制遺伝子RBによるSREBP-1の制御とがんにおける役割の解析
- Author(s)
  村中勇人, 北嶋俊輔, 佐々木信成, 河野晋, 林昭夫, 多田秀明, 丹下正一郎, 鈴木健人, Shamma A, 髙橋智聡
- Organizer
  日本癌学会シンポジウム / 共同利用・共同研究拠点シンポジウム
- Place of Presentation
  石川県立音楽堂交流ホール
- Year and Date
  2015-01-21 – 2015-01-22
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] RBによるメバロン酸経路を介したがん悪性進展制御機構
- Author(s)
  佐々木信成, 村中勇人, 北嶋俊輔, 河野晋, Shamma A, 髙橋智聡
- Organizer
  日本癌学会シンポジウム / 共同利用・共同研究拠点シンポジウム
- Place of Presentation
  石川県立音楽堂交流ホール
- Year and Date
  2015-01-21 – 2015-01-22
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] がん抑制遺伝子RBによるSREBP-1の制御とがんにおける役割の解析
- Author(s)
  村中勇人, 北嶋俊輔, 佐々木信成, 河野晋, Shamma A, 髙橋智聡
- Organizer
  平成26年度がん若手研究者ワークショップ
- Place of Presentation
  蓼科　蓼科グランドホテル滝の湯
- Year and Date
  2014-09-03 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] がん抑制遺伝子RBによるSREBP-1の制御とがんにおける役割の解析
- Author(s)
  村中勇人, 北嶋俊輔, 佐々木信成, 河野晋, 吉田晶代, 丹下正一朗, 鈴木健之, 林昭夫, 多田秀昭, Shamma A, 髙橋智聡
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜　パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] The metabolic function of RB in controlling mevalonate (MVA) pathway and tumor progression
- Author(s)
  Sasaki N, Muranaka H, Kitajima S, Kohno S, Shamma A and Takahashi C
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜　パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] RBの中心代謝制御機能
- Author(s)
  河野晋, 北嶋俊輔, 吉田晶代, 鈴木佐和子, 田中知明, 佐々木信成, 村中勇人, 髙橋智聡
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜　パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] The metabolic function of RB in controlling mevalonate (MVA) pathway regulates tumor progression
- Author(s)
  Sasaki N, Kitajima S, Muranaka H, Shamma A, Kohno S, Takahashi C
- Organizer
  Keyston Symposia
- Place of Presentation
  Fairmont Hotel Vancouver, Vancouver, Canada
- Year and Date
  2015-01-13 – 2015-01-18
- Data Source
  KAKENHI-PROJECT-25830076
[Presentation] RB不活性化によって誘導されるがん幹細胞様未分化状態におけるPgam2の役割
- Author(s)
  河野晋, 北嶋俊輔, 佐々木信成, 村中勇人, 鈴木佐和子, 田中知明, 岡橋伸幸, 松田史生, 清水浩, 髙橋智聡
- Organizer
  第2回がんと代謝研究会
- Place of Presentation
  東京　東京理科大学葛飾キャンパス図書館大ホール
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25830076

1. Takahashi Chiaki (50283619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. Hayashi Naoyuki (50253456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. Kitajima Syunsuke (90566465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. Shamma Awad (50402839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. Kohno Susumu (30625463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. 見学美根子 (10303801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 金清華 (50415189)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 永樂元次 (40415097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小林昌彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SASAKI Nobunari 佐々木 信成

佐々木 信成 ササキ ノブナリ

Sasaki Nobunari 佐々木 信成

SASAKI Nobuari 佐々木 信成

Research Projects

Research Products

Co-Researchers

LKB1/KEAP1変異に伴う腫瘍免疫制御を介したソトラシブ耐性機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of metabolism by RB tumor suppressor gene

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The metabolic function of RB in controlling mevalonate (MVA) pathway regulates tumor progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞間シグナルによる中枢神経系ニューロン・グリア突起の分岐パターン制御機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 『代謝変化とエピジェテックス制御』「RBがん抑制遺伝子産物による細胞未分化性制御」2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] <i>TREX1</i> Inactivation Unleashes Cancer Cell STING-Interferon Signaling and Promotes Antitumor Immunity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting the loss of <scp>cGAS</scp>/<scp>STING</scp> signaling in cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity.2017

Author(s)

Journal Title

Data Source

[Journal Article] RB tumor suppressor functions shared by stem cell and cancer cell strategies.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Undifferentiated State Induced by Rb-P53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ATM mediates pRB function to control DNMT1 protein stability and DNA methylation.2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] The metabolic function of RB in controlling mevalonate (MVA) pathway regulates tumor progression2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] The metabolic function of RB in controlling mevalonate (MVA) pathway and tumor progression.2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] RBによるメバロン酸経路を介したがん悪性進展制御機構.2014

Author(s)

SASAKI Nobunari 佐々木信成

佐々木信成ササキノブナリ

Sasaki Nobunari 佐々木信成

SASAKI Nobuari 佐々木信成