Kina Shinichiro 喜名振一郎

… Alternative Names

KINA Shinichiro 喜名振一郎

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Researcher Number	40422422
Other IDs
Affiliation (Current)	2025: 琉球大学, 医学(系)研究科(研究院), 准教授 2025: 群馬大学, 大学院医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2018 – 2024: 群馬大学, 大学院医学系研究科, 講師 2017: 琉球大学, 医学(系)研究科(研究院), 助教 2011 – 2014: 琉球大学, 医学(系)研究科(研究院), 助教 2013: 琉球大学, 大学院医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry / Pathobiological dentistry/Dental radiology Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Basic Section 53050:Dermatology-related / Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Keywords	Principal Investigator 術前メトロノーム化学療法 / 抗癌剤耐性 / 頭頸部癌 / メトロノーム化学療法 / 術前化学療法 / 口腔癌 / 抗がん剤 / チロシンリン酸化 / 高分化型 / EphA4 … More / 高分化型腫瘍 / 癌治療 / 舌癌 / Met / 分子標的薬 / 抗癌剤 / PDGF 受容体 … More Except Principal Investigator HPV / 臨床応用 / 予後 / PARP活性 / 中咽頭癌 / 免疫細胞活性化 / KSHV K1遺伝子 / 細胞外ドメイン / K1 / 形質転換能 / K1遺伝子 / 自然消退 / 古典型 / KSHV / カポジ肉腫 / 分子生学的メカニズム / 抗癌剤耐性 / 高分化型口腔癌 / EphA4 / 口腔癌 / 高分化型腫瘍 / メトロノーム化学療法 / Met / シスプラチン / PDGFR / 分子標的薬 Less

PARP activity in HPV-positive oropharyngeal carcinoma: the mechanism of favorable prognosis and development of effective therapy
- Principal Investigator
  
  金城貴夫
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  University of the Ryukyus
Wnt 経路を介した組織学的分化度依存的に生じる腫瘍血管形成機構の解明Principal Investigator
- Principal Investigator
  
  喜名振一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Gunma University
Investigation of the mechanism for metronomic chemotherapy resistance in well-differentiated oral cancer driven by EphA4 activationPrincipal Investigator
- Principal Investigator
  
  Kina Shinichiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Gunma University
Spontaneous regression of classic type Kaposi's sarcoma and therapeutic application for cancer
- Principal Investigator
  
  Kinjo Takao
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  University of the Ryukyus
Clarification of molecular biological mechanism targeting EphA4 against the anticancer drug resistance well-differentiated oral squamous cell carcinoma
- Principal Investigator
  
  Nakasone Toshiyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  University of the Ryukyus
Construction of new therapy method that targets EphA4 which is activated by chemotherapeutic reagentsPrincipal Investigator
- Principal Investigator
  
  Kina Shinichiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Gunma University
  University of the Ryukyus
The analysis of developing metastasis induced by cancer treatmentPrincipal Investigator
- Principal Investigator
  
  KINA Shinichiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  University of the Ryukyus
Investigation of effective use of molecular targeting on HPV related tumors
- Principal Investigator
  
  SUNAKAWA Hajime
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  University of the Ryukyus

All 2024 2023 2022 2021 2020 2019 2018 2017 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Higher overall survival rates of oral squamous cell carcinoma treated with metronomic neoadjuvant chemotherapy2024
- Author(s)
  Shinichiro Kina , Sho Miyamoto , Reika Kawabata-Iwakawa , Mika Kina-Tanada , Masaru Ogawa , Satoshi Yokoo
- Journal Title
  
  American Journal of Cancer Research
  
  Volume: 14 Issue: 3 Pages: 1033-1051
- DOI
  10.62347/eynt8387
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K16141, KAKENHI-PROJECT-21K10084
[Journal Article] EphA4 signaling is involved in the phenotype of well-differentiated oral squamous cell arcinoma with decreased tumor immunity2023
- Author(s)
  Kina Shinichiro、Kawabata-Iwakawa Reika、Miyamoto Sho、Kato Tomoki、Kina-Tanada Mika、Arasaki Akira
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 945 Pages: 175611-175611
- DOI
  10.1016/j.ejphar.2023.175611
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10084, KAKENHI-PROJECT-19K19171
[Journal Article] Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy2023
- Author(s)
  Miyamoto Sho、Hirohashi Yoshihiko、Morita Rena、Miyazaki Akihiro、Ogi Kazuhiro、Kanaseki Takayuki、Ide Kentaro、Shirakawa Jumpei、Tsukahara Tomohide、Murai Aiko、Sasaya Takashi、Koike Kazushige、Kina Shinichiro、Kawano Toshihiro、Goto Takahiro、Ntege Edward Hosea、Shimizu Yusuke、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 9 Pages: 3496-3508
- DOI
  10.1111/cas.15873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10084, KAKENHI-PROJECT-23K27794
[Journal Article] Cytological characteristics of premalignant cervical epithelial lesions in postmenopausal women based on endocrine indices and parakeratosis2022
- Author(s)
  Sugisawa Akiyuki、Toyoda Zensei、Tanabe Yasuka、Uehara Karina、Oshiro Aya、Yamazato Reo、Sakamoto Chiharu、Yogi Shohei、Kurima Kiyoto、Kina Shinichiro、Sakiyama Michiyo、Kinjo Takao
- Journal Title
  
  Menopause
  
  Volume: 30 Issue: 2 Pages: 193-200
- DOI
  10.1097/gme.0000000000002125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10084, KAKENHI-PROJECT-20K08655
[Journal Article] Co-expression of low-risk HPV E6/E7 and EBV LMP-1 leads to precancerous lesions by DNA damage2021
- Author(s)
  Uehara K, Tanabe Y, Hirota S, Higa S, Toyoda Z, Kurima K, Kina S, Nakasone T, Arasaki A, Kinjo T.
- Journal Title
  
  BMC Cancer.
  
  Volume: 21 Issue: 1 Pages: 688-688
- DOI
  10.1186/s12885-021-08397-0
- NAID
  120007168809
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08655, KAKENHI-PROJECT-21K10084
[Journal Article] A molecular signature of well-differentiated oral squamous cell carcinoma reveals a resistance mechanism to metronomic chemotherapy and novel therapeutic candidates2021
- Author(s)
  Kina S, Kawabata-Iwakawa R, Miyamoto S, Arasaki A, Sunakawa H, Kinjo T.
- Journal Title
  
  J Drug Target.
  
  Volume: 29 Issue: 10 Pages: 1118-1127
- DOI
  10.1080/1061186x.2021.1929256
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08655, KAKENHI-PROJECT-21K10084
[Journal Article] Fyn‐mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin‐releasing hormone receptor2020
- Author(s)
  Higa‐Nakamine Sayomi、Okitsu‐Sakurayama Shiho、Kina Shinichiro、Yamamoto Hideyuki
- Journal Title
  
  The FEBS Journal
  
  Volume: - Issue: 16 Pages: 1-12
- DOI
  10.1111/febs.15231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07112, KAKENHI-PROJECT-17K11881
[Journal Article] K1 gene transformation activities in AIDS-related and classic type Kaposi’s sarcoma: Correlation with clinical presentation2019
- Author(s)
  Tamanaha-Nakasone Ayumi、Uehara Karina、Tanabe Yasuka、Ishikawa Haruna、Yamakawa Natsuko、Toyoda Zensei、Kurima Kiyoto、Kina Shinichiro、Tsuneki Masayuki、Okubo Yuko、Yamaguchi Sayaka、Utsumi Daisuke、Takahashi Kenzo、Arakawa Hirofumi、Arasaki Akira、Kinjo Takao
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41598-019-42763-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17030, KAKENHI-PROJECT-16K10167, KAKENHI-PROJECT-16K10436, KAKENHI-PROJECT-18K08303, KAKENHI-PROJECT-18K09773, KAKENHI-PROJECT-19K08778, KAKENHI-PROJECT-17K11881, KAKENHI-PROJECT-19K21277, KAKENHI-PROJECT-20K20305
[Journal Article] Outcomes after up-front surgery and metronomic neoadjuvant chemotherapy with S-1 or UFT for early tongue squamous cell carcinoma2018
- Author(s)
  Kina Shinichiro、Nakasone Toshiyuki、Kinjo Takao、Nimura Fumikazu、Sunagawa Nao、Arasaki Akira
- Journal Title
  
  Clinical Oral Investigations
  
  Volume: - Issue: 6 Pages: 1-6
- DOI
  10.1007/s00784-018-2689-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11881, KAKENHI-PROJECT-18K09729
[Journal Article] Targeting EphA4 abrogates intrinsic resistance to chemotherapy in well-differentiated cervical cancer cell line.2018
- Author(s)
  Kina S, Kinjo T, Liang F, Nakasone T, Yamamoto H, Arasaki A.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 840 Pages: 70-78
- DOI
  10.1016/j.ejphar.2018.09.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11881, KAKENHI-PROJECT-18K09729
[Journal Article] PDGFαreceptor is a mediator for Cisplatin-induced Met expression2013
- Author(s)
  Kina S, Phonaphonh T, Liang F, Kuang H, Arasaki A, Arakaki K, Nakasone T, Sunakawa H.
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 699(1-3) Pages: 227-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592930
[Journal Article] PDGF α receptor is a mediator for Cisplatin-induced Met expression.2012
- Author(s)
  Kina S, Phonaphonh T, Liang F, Kuang H, Arasaki A, Arakaki K, Nakasone T, Sunakawa H.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 699 Pages: 227-232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792004
[Journal Article] PDGF α receptor is a mediator for Cisplatin-induced Met expression2012
- Author(s)
  Shinichiro Kina, Thongsavanh Phonaphonh, Feixin Liang, Hai Kuang, Akira Arasaki, Keiichi Arakaki, Toshiyuki Nakasone, Hajime Sunakawa
- Journal Title
  
  European Journal of Pharmcology
  
  Volume: 699 Pages: 227-232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592930
[Journal Article] HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells2011
- Author(s)
  Feixin Liang, Shinichiro Kina, Hiroyuki Takemoto, Akira Matayoshi, Thongsavanh Phonaphonh, Nao Sunagawa, Keiichi Arakaki, Akira Arasaki, Hai Kuang, and Hajime Sunakawa
- Journal Title
  
  Mediators Inflamm.
  
  Volume: 2011 Pages: 1-7
- DOI
  10.1155/2011/263216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592930
[Journal Article] HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells2011
- Author(s)
  Feixin Liang, Shinichiro Kina, Hiroyuki Takemoto, Akira Matayoshi, Thongsavanh Phonaphonh, Nao Sunagawa, Keiichi Arakaki, Akira Arasaki, Hai Kuang, and Hajime Sunakawa
- Journal Title
  
  Mediators of Inflammation
  
  Volume: Volume 2011(Article ID 263216) Pages: 7-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592930
[Presentation] 高分化型口腔扁平上皮癌が有するメトロノーム化学療法耐性機構の解明2022
- Author(s)
  喜名振一郎、宮本昇、加藤大貴
- Organizer
  第４０回口腔腫瘍学会
- Data Source
  KAKENHI-PROJECT-21K10084
[Presentation] 口腔癌細胞株におけるPARP活性とシスプラチン感受性について2020
- Author(s)
  山川奈津子、上原佳里奈、喜名振一郎、新崎章、金城貴夫
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-20K08655
[Presentation] 受容体型チロシンキナーゼEphA4 の高分化型腫瘍における抗癌剤耐性能について2017
- Author(s)
  喜名振一郎、山本秀幸、仲嶺三代美、鳥原英嗣、金城貴夫、新崎章
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K11881
[Presentation] PDGFR はシスプラチン依存的なMet の発現上昇を制御する2013
- Author(s)
  喜名　振一郎
- Organizer
  第37回頭頸部癌学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24792004
[Presentation] 最新の臨床研究[HPV感染細胞の活性酸素感受性について]2011
- Author(s)
  喜名振一郎
- Organizer
  第56回社団法人日本口腔外科学会総会・学術大会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-23592930
[Presentation] 舌癌に対する術前化学療法
- Author(s)
  喜名　振一郎
- Organizer
  日本口腔外科学会
- Place of Presentation
  千葉県　幕張メッセ
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-24792004

1. Kinjo Takao (30284962)

# of Collaborated Projects: 6 results

# of Collaborated Products: 7 results
2. 喜名美香 (80578914)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. Nakasone Toshiyuki (40381214)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 宮本昇 (80749565)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. SUNAKAWA Hajime (30112452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. NIMURA Humikazu (50457678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 田中勇悦 (30163588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 上原佳里奈 (30782594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 荒川博文 (70313088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 高橋健造 (80291425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 川端麗香 (90721928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 与儀翔平 (60973716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 比嘉三代美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 山本秀幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kina Shinichiro 喜名 振一郎

KINA Shinichiro 喜名 振一郎

Research Projects

Research Products

Co-Researchers

PARP activity in HPV-positive oropharyngeal carcinoma: the mechanism of favorable prognosis and development of effective therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Wnt 経路を介した組織学的分化度依存的に生じる腫瘍血管形成機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the mechanism for metronomic chemotherapy resistance in well-differentiated oral cancer driven by EphA4 activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Spontaneous regression of classic type Kaposi's sarcoma and therapeutic application for cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of molecular biological mechanism targeting EphA4 against the anticancer drug resistance well-differentiated oral squamous cell carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of new therapy method that targets EphA4 which is activated by chemotherapeutic reagentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of developing metastasis induced by cancer treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of effective use of molecular targeting on HPV related tumors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Higher overall survival rates of oral squamous cell carcinoma treated with metronomic neoadjuvant chemotherapy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EphA4 signaling is involved in the phenotype of well-differentiated oral squamous cell arcinoma with decreased tumor immunity2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytological characteristics of premalignant cervical epithelial lesions in postmenopausal women based on endocrine indices and parakeratosis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Co-expression of low-risk HPV E6/E7 and EBV LMP-1 leads to precancerous lesions by DNA damage2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A molecular signature of well-differentiated oral squamous cell carcinoma reveals a resistance mechanism to metronomic chemotherapy and novel therapeutic candidates2021

Kina Shinichiro 喜名振一郎

KINA Shinichiro 喜名振一郎