DENG LIN デンリン

… Alternative Names

Deng Lin デンリン

DENG Lin デンリン

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Researcher Number	40437497
Other IDs	https://orcid.org/0000-0002-5993-6597
Affiliation (Current)	2025: 神戸大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 神戸大学, 医学研究科, 助教 2014: 神戸大学, 大学院医学研究科, 助教 2012 – 2014: 神戸大学, 医学(系)研究科(研究院), 助教 2011: 神戸大学, 医学(系)研究科(研究院), グローバルＣＯＥ研究員 2010: Kobe University, 大学院・医学研究科, グローバルCOE研究員 … More 2009 – 2010: Kobe University, 医学研究科, グローバルCOE研究員 2008: Kobe University, 医学研究科, グロバルCOE研究員 2008: Kobe University, 大学院・医学研究科, グローバルCOE研究員 2007: Kobe University, 医学部, 学術研究員 Less
Review Section/Research Field	Principal Investigator Virology / Basic Section 49060:Virology-related Except Principal Investigator Gastroenterology
Keywords	Principal Investigator C型肝炎ウイルス / ミトコンドリア / アポトーシス / HBx / HBV RNA分解 / 抗酸化応答 / HBV RNA 分解 / HBV / Prdx1 / Nrf2 … More / 抗酸化防御機構 / B型肝炎ウイルス / シグナル / Ｃ型肝炎ウイルス / 癌化 / 感染症 / AGR3 / SMYD3 / NS5A / 発癌 / JNK / Bax … More Except Principal Investigator FoxO1 / Ｃ型肝炎ウイルス / Bim / アポトーシス / MKP3 / 脱リン酸化 / Fox01 / 糖新生 / 感染症 / C型肝炎ウイルス Less

Analysis of the effect of Nrf2-Prdx1 pathway on the degradation of hepatitis B virus RNAPrincipal Investigator
- Principal Investigator
  
  Deng Lin
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Kobe University
Study on molecular mechanisms of glucose metabolic disorders mediated by hepatitis C virus
- Principal Investigator
  
  HOTTA Hak
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kobe University
Study on the mechanisms of HCV-mediated carcinogenesisPrincipal Investigator
- Principal Investigator
  
  DENG Lin
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kobe University
Study on the mechanism of hepatitis C virus infection-induced apoptosisPrincipal Investigator
- Principal Investigator
  
  DENG LIN
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Kobe University
Study on the mechanism of hepatitis C virus infection-induced cytopathic effectPrincipal Investigator
- Principal Investigator
  
  DENG Lin
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Kobe University

All 2023 2022 2021 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Transcription Factor JunB Suppresses Hepatitis C Virus Replication2023
- Author(s)
  Adi Ariffianto, Lin Deng, Saki Harada, Yujiao Liang, Chieko Matsui, Takayuki Abe, Ikuo Shoji
- Journal Title
  
  Kobe Journal of Medical Sciences
  
  Volume: 69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07040
[Journal Article] Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal Pathways2023
- Author(s)
  Deng Lin、Solichin Muchamad Ridotu、Adyaksa Dewa Nyoman Murti、Septianastiti Maria Alethea、Fitri Rhamadianti Aulia、Suwardan Gede Ngurah Rsi、Matsui Chieko、Abe Takayuki、Shoji Ikuo
- Journal Title
  
  Viruses
  
  Volume: 15 Issue: 12 Pages: 2430-2430
- DOI
  10.3390/v15122430
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15470, KAKENHI-PROJECT-21K07040
[Journal Article] Hepatitis C Virus Disrupts Annexin 5-Mediated Occludin Integrity through Downregulation of Protein Kinase Cα (PKCα) and PKCη Expression, Thereby Promoting Viral Propagation2023
- Author(s)
  Abe Takayuki、Marutani Yuki、Deng Lin、Matsui Chieko、Fukasawa Masayoshi、Suzuki Ryosuke、Wakita Takaji、Matsuura Yoshiharu、Shoji Ikuo
- Journal Title
  
  Journal of Virology
  
  Volume: 97 Issue: 6
- DOI
  10.1128/jvi.00655-23
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15470, KAKENHI-PROJECT-21K07040
[Journal Article] Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication2023
- Author(s)
  Ariffianto Adi、Deng Lin、Abe Takayuki、Matsui Chieko、Ito Masahiko、Ryo Akihide、Aly Hussein Hassan、Watashi Koichi、Suzuki Tetsuro、Mizokami Masashi、Matsuura Yoshiharu、Shoji Ikuo
- Journal Title
  
  Journal of Virology
  
  Volume: 97 Issue: 10 Pages: 1-35
- DOI
  10.1128/jvi.01287-23
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15470, KAKENHI-PROJECT-21K07040, KAKENHI-PROJECT-21K07051, KAKENHI-PROJECT-23K27415
[Journal Article] Complete genome analyses of G12P[8] rotavirus strains from hospitalized children in Surabaya, Indonesia, 2017-20182023
- Author(s)
  Laura Navika Yamani, Takako Utsumi, Yen Hai Doan, Yoshiki Fujii, Zayyin Dinana, Rury Mega Wahyuni, Emily Gunawan, Soegeng Soegijanto, Alpha Fardah Athiyyah, Subijanto Marto Sudarmo, Reza Gunadi Ranuh, Andy Darma, Soetjipto, Juniastuti, Rheza Gandi Bawono, Chieko Matsui, Lin Deng, etc.
- Journal Title
  
  Journal of Medical Virology
  
  Volume: 95 Issue: 2
- DOI
  10.1002/jmv.28485
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040, KAKENHI-PROJECT-22K07095, KAKENHI-PROJECT-19H04354, KAKENHI-PROJECT-22K15470
[Journal Article] A household survey of intrafamily norovirus transmission2023
- Author(s)
  Juniastuti、Utsumi Takako、Yamani Laura Navika、Dinana Zayyin、Gunawan Emily、Maharani Aussie Tahta、Fitria Anisa Lailatul、Wahyuni Rury M.、Soetjipto、Doan Yen Hai、Shimizu Hiroyuki、Ishii Koji、Matsui Chieko、Deng Lin、Abe Takayuki、Katayama Kazuhiko、Lusida Maria Inge、Shoji Ikuo
- Journal Title
  
  Journal of Medical Virology
  
  Volume: 95 Issue: 10
- DOI
  10.1002/jmv.29164
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15470, KAKENHI-PROJECT-21K07040
[Journal Article] Hepatitis C virus NS5A protein promotes the lysosomal degradation of diacylglycerol O-acyltransferase 1 (DGAT1) via endosomal microautophagy2022
- Author(s)
  Putu Yuliandari, Chieko Matsui, Lin Deng, Takayuki Abe, Hiroyuki Mori, Shuhei Taguwa, Chikako Ono, Takasuke Fukuhara, Yoshiharu Matsuura, Ikuo Shoji
- Journal Title
  
  Autophagy Reports
  
  Volume: 1 Issue: 1 Pages: 264-285
- DOI
  10.1080/27694127.2022.2095591
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040, KAKENHI-PROJECT-22K15470, KAKENHI-PROJECT-19H04354, KAKENHI-PROJECT-20K07514
[Journal Article] Hepatitis C Virus-Induced ROS/JNK Signaling Pathway Activates the E3 Ubiquitin Ligase Itch to Promote the Release of HCV Particles via Polyubiquitylation of VPS4A2022
- Author(s)
  Deng Lin、Liang Yujiao、Ariffianto Adi、Matsui Chieko、Abe Takayuki、Muramatsu Masamichi、Wakita Takaji、Maki Masatoshi、Shibata Hideki、Shoji Ikuo
- Journal Title
  
  Journal of Virology
  
  Volume: 96 Issue: 6 Pages: 1811-21
- DOI
  10.1128/jvi.01811-21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08369, KAKENHI-PROJECT-21K07040, KAKENHI-PROJECT-22K15470, KAKENHI-PROJECT-19H04354, KAKENHI-PROJECT-20K07514
[Journal Article] HERC5 E3 ligase mediates ISGylation of hepatitis B virus X protein to promote viral replication2021
- Author(s)
  Bawono Rheza Gandi、Abe Takayuki、Qu Mengting、Kuroki Daisuke、Deng Lin、Matsui Chieko、Ryo Akihide、Suzuki Tetsuro、Matsuura Yoshiharu、Sugiyama Masaya、Mizokami Masashi、Shimotohno Kunitada、Shoji Ikuo
- Journal Title
  
  Journal of General Virology
  
  Volume: 102 Issue: 10
- DOI
  10.1099/jgv.0.001668
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07040
[Journal Article] The Role of Chaperone-Mediated Autophagy in Hepatitis C Virus-Induced Pathogenesis2021
- Author(s)
  Matsui Chieko、Yuliandari Putu、Deng Lin、Abe Takayuki、Shoji Ikuo
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 11 Pages: 1-8
- DOI
  10.3389/fcimb.2021.796664
- NAID
  120007184287
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07514, KAKENHI-PROJECT-21K07040
[Journal Article] Molecular epidemiology and genetic diversity of norovirus infection in children hospitalized with acute gastroenteritis in East Java, Indonesia in 2015?20192021
- Author(s)
  Utsumi Takako、Lusida Maria Inge、Dinana Zayyin、Wahyuni Rury Mega、Soegijanto Soegeng、Soetjipto、Athiyyah Alpha Fardah、Sudarmo Subijanto Marto、Ranuh Reza Gunadi、Darma Andy、Juniastuti、Ishii Koji、Shoji Ikuo et al.
- Journal Title
  
  Infection, Genetics and Evolution
  
  Volume: 88 Pages: 104703-104703
- DOI
  10.1016/j.meegid.2020.104703
- NAID
  120006993632
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04354, KAKENHI-PROJECT-21K07040
[Journal Article] NS5A-ISGylation via Lysine 26 Has a Critical Role for Efficient Propagation of Hepatitis C Virus Genotype 2a2021
- Author(s)
  Bawono Rheza Gandi, Abe Takayuki, Shibata Yasuaki, Matsui Chieko, Deng Lin, Shoji Ikuo.
- Journal Title
  
  Kobe Journal of Medical Sciences
  
  Volume: 67
- NAID
  120007169870
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07040
[Journal Article] NS5B induces up-regulation of the BH3-only protein, BIK, essential for the hepatitis C virus RNA replication and viral release.2015
- Author(s)
  Aweya JJ, Sze CW, Bayega A, Mohd-Ismail NK, Deng L, Hotta H, Tan YJ
- Journal Title
  
  Virology
  
  Volume: 474 Pages: 41-51
- DOI
  10.1016/j.virol.2014.10.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590976
[Journal Article] The NS5A protein of hepatitis C virus transcriptionally upregulates the AGR3 gene expression.2015
- Author(s)
  Chen M, Gan X, Deng L, Hotta H
- Journal Title
  
  Kobe J Med Sci
  
  Volume: 61(1)
- NAID
  120005617324
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590976
[Journal Article] A single-amino-acid mutation in hepatitis C virus NS5A disrupts physical and functional interaction with the transcription factor HNF-1α.2015
- Author(s)
  Matsui C, Sianipar I R, Minami N, Deng L, Hotta H, Shoji I
- Journal Title
  
  J Gen Virol
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590976
[Journal Article] Virocidal activity of Egyptian scorpion venoms against hepatitis C virus.2015
- Author(s)
  El-Bitar AM, Sarhan MM, Aoki C, Takahara Y, Komoto M, Deng L, Moustafa MA, Hotta H
- Journal Title
  
  Virol J
  
  Volume: 12(1) Issue: 1 Pages: 47-47
- DOI
  10.1186/s12985-015-0276-6
- NAID
  120005705276
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590976
[Journal Article] Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species2014
- Author(s)
  Adianti M, Aoki C, Komoto M, Deng L, Shoji I, Wahyuni TS, Lusida MI, Soetjipto, Fuchino H, Kawahara N, Hotta H
- Journal Title
  
  Microbiol Immunol
  
  Volume: 58(3) Issue: 3 Pages: 180-7
- DOI
  10.1111/1348-0421.12127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590543, KAKENHI-PROJECT-24590976
[Journal Article] Antiviral activity of extracts from Morinda citrifolia leaves and chlorophyll catabolites, pheophorbide a and pyropheophorbide a, against hepatitis C virus.2014
- Author(s)
  Ratnoglik SL, Aoki C, Sudarmono P, Komoto M, Deng L, Shoji I, Fuchino H, Kawahara N, Hotta H.
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 58 Issue: 3 Pages: 188-194
- DOI
  10.1111/1348-0421.12133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590543, KAKENHI-PROJECT-24590976
[Journal Article] Induction of cell-mediated immune responses in mice by DNA vaccines that express hepatitis C virus NS3 mutants lacking serine protease and NTPase/RNA helicase activities.2014
- Author(s)
  Ratnoglik SL, Jiang DP, Aoki C, Sudarmono P, Shoji I, Deng L, Hotta H
- Journal Title
  
  PLoS One
  
  Volume: 9(6) Issue: 6 Pages: 1-9
- DOI
  10.1371/journal.pone.0098877
- NAID
  120005705278
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590976, KAKENHI-PROJECT-26461003
[Journal Article] Antiviral activities of Indonesian medicinal plants in the East Java region against hepatitis C virus.2013
- Author(s)
  Wahyuni TS, Tumewu L, Permanasari AA, Apriani E, Adianti M, Rahman A, Widyawaruyanti A, Lusida MI, Fuad A, Soetjipto D, Nasronudin D, Fuchino H, Kawahara N, Shoji I, Deng L, Aoki C, Hotta H.
- Journal Title
  
  Virology Journal
  
  Volume: 10 Issue: 1 Pages: 259-259
- DOI
  10.1186/1743-422x-10-259
- NAID
  120005705279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590543, KAKENHI-PROJECT-24590976
[Journal Article] Polymorphisms of the core, NS3 and NS5A proteins of hepatitis C virus genotype 1b associate with development of hepatocellular carcinoma.2013
- Author(s)
  El-Shamy A, Shindo M, Shoji I, Deng L, Okuno T, Hotta H.
- Journal Title
  
  Hepatology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590976
[Journal Article] Polymorphisms of hepatitis C virus NS5A and core proteins and clinical outcome of pegylated interferon/ribavirin therapy2012
- Author(s)
  El-Shamy A, Ide Y-H, Kim SR, Sasase N, Imoto S, Deng L, Shoji I, Hotta H
- Journal Title
  
  Inervirology
  
  Volume: 55 Issue: 1 Pages: 1-11
- DOI
  10.1159/000322219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590731, KAKENHI-PROJECT-23590543
[Journal Article] Sequence heterogeneity in NS5A of hepatitis C virus genotype 2a and 2b and clinical outcome of pegylated interferon/ribavirin therapy2012
- Author(s)
  El-Shamy A., Shoji I, Kim SR, Imoto S, Deng L, Yoon S, Fujisawa T, Tani S, Yano Y, Seo Y, Azuma T, Hotta H
- Journal Title
  
  PLoS One
  
  Volume: 55 Issue: 2 Pages: 1-10
- DOI
  10.1371/journal.pone.0030513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590731, KAKENHI-PROJECT-23590543
[Journal Article] Prediction of response to pegylated interferon/ribavirin combination therapy for chronic hepatitis C genotype 1b and high viral load.2012
- Author(s)
  Soo Ryang Kim
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 47 Issue: 10 Pages: 1143-1151
- DOI
  10.1007/s00535-012-0578-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590543, KAKENHI-PROJECT-24590976
[Journal Article] Hepatitis C virus infection suppresses GLUT2 gene expression via downregulation of hepatocyte nuclear factor 1α.2012
- Author(s)
  Matsui C
- Journal Title
  
  J Virol.
  
  Volume: 86 Issue: 23 Pages: 12903-12911
- DOI
  10.1128/jvi.01418-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590731, KAKENHI-PROJECT-23590543, KAKENHI-PROJECT-24590976
[Journal Article] Generation of a recombinant reporter hepatitis C virus useful for the analyses of virus entry, intra-cellular replication and virion production2012
- Author(s)
  Kamada K, Shoji I, Deng L, Aoki C, Ratnoglik SL, Wakita T, Hotta H
- Journal Title
  
  Microbes Infect
  
  Volume: 14(1) Issue: 1 Pages: 69-78
- DOI
  10.1016/j.micinf.2011.08.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590543
[Journal Article] Polymorphisms of the core, NS3 and NS5A proteins of hepatitis C 1 virus genotype 1b associate with development of hepatocellular carcinoma.2012
- Author(s)
  Ahmed EL-Shamy
- Journal Title
  
  Hepatology
  
  Volume: - Issue: 2 Pages: 555-563
- DOI
  10.1002/hep.26205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590543, KAKENHI-PROJECT-24590976
[Journal Article] HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells.2012
- Author(s)
  Nakashima, K.
- Journal Title
  
  PLoS One
  
  Volume: 7(10) Issue: 10 Pages: e46634-e46634
- DOI
  10.1371/journal.pone.0046634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590285, KAKENHI-PROJECT-22590731, KAKENHI-PROJECT-23590543, KAKENHI-PROJECT-24590976
[Journal Article] NS5A sequence heterogeneity of hepatitis C virus genotype 4a predicts clinical outcome of pegylated-interferon-ribavirin therapy in Egyptian patients.2012
- Author(s)
  Ahmed EL-Shamy
- Journal Title
  
  Journal of Clinical Microbiology
  
  Volume: 50 Issue: 12 Pages: 3886-3892
- DOI
  10.1128/jcm.02109-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590543, KAKENHI-PROJECT-24590976
[Journal Article] A point mutation at Asn-534 that disrupts a conserved N-glycosylation motif of the E2 glycoprotein of hepatitis C virus markedly enhances the sensitivity to antibody neutralization2012
- Author(s)
  Sasayama M., Shoji I., Ide Y-H., Deng L., Hotta H
- Journal Title
  
  Journal of Medical Virology
  
  Volume: 84 Issue: 2 Pages: 229-234
- DOI
  10.1002/jmv.22257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590731, KAKENHI-PROJECT-23590543
[Journal Article] Molecular mechanism of hepatitis C virus-induced glucose metabolic disorders2012
- Author(s)
  Shoji I, Deng L, Hotta H
- Journal Title
  
  Front Microbiol
  
  Volume: 2 Pages: 278-278
- DOI
  10.3389/fmicb.2011.00278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590543
[Journal Article] Polymorphisms of Hepatitis C Virus NS5A and Core Protein and Clinical Outcome of Pegylated-Interferon/ /Ribavirin Combination Therapy.2011
- Author(s)
  El-Shamy A, Kim SR, Ide YH, Sasase N, Imoto S, Deng L, Shoji I, Hotta H.
- Journal Title
  
  Intervirology in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790446
[Journal Article] Sequence heterogeneity of NS5A and core proteins of hepatitis C virus and virological responses to pegylated-interferon/ribavirin combination therapy.2011
- Author(s)
  El-Shamy A, Shoji I, Saito T, Watanabe H, Ide YH, Deng L, Kawata S, Hotta H.
- Journal Title
  
  Microbiol.Immunol. in press
- NAID
  10031121486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790446
[Journal Article] Hepatitis C Virus Infection Promotes Hepatic Gluconeogenesis through an NS5A-Mediated, FoxO1-Dependent Pathway2011
- Author(s)
  Deng, L.
- Journal Title
  
  J.Virol.
  
  Volume: 85 Issue: 17 Pages: 8556-8568
- DOI
  10.1128/jvi.00146-11
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134007, KAKENHI-PROJECT-22590731, KAKENHI-PROJECT-23590543
[Journal Article] Potential therapeutic application of intravenous bone marrow infusion in patients with alcoholic liver cirrhosis2011
- Author(s)
  Saito T, Okumoto K, Haga H, Nishise Y, Ishii R, Sato C, Watanabe H, Okada A, Ikeda M, Togashi H, Ishikawa T, Terai S, Sakaida I, Kawata S
- Journal Title
  
  Stem Cells Dev
  
  Volume: 20 Issue: 6 Pages: 1503-1510
- DOI
  10.1111/j.1348-0421.2011.00331.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590824, KAKENHI-PROJECT-22590731, KAKENHI-PROJECT-23590543
[Journal Article] Secondary structure of the amino-terminal region of HCV NS3 and virological response to pegylated interferon plus ribavirin therapy for chronic hepatitis C.2010
- Author(s)
  Sanjo M, Saito T, Ishii R, Nishise Y, Haga H, Okumoto K, Ito J, Watanabe H, Saito K, Togashi H, Fukuda K, Imai Y, El-Shamy A, Deng L, Shoji I, Hotta H, Kawata S.
- Journal Title
  
  J.Med.Virol. 82(8)
  
  Pages: 1364-1370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790446
[Journal Article] 17β-estradiol inhibits the production of infectious particles of hepatitis C virus.2010
- Author(s)
  Hayashida K, Shoji I, Deng L, Jiang DP, Ide YH, Hotta H.
- Journal Title
  
  Microbiol.Immunol. 54(11)
  
  Pages: 684-689
- NAID
  10029546273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790446
[Journal Article] Analysis of neutralizing antibodies against hepatitis C virus in patients who were treated with pegylated-interferon plus ribavirin.2010
- Author(s)
  Sasayama M, Deng L, Kim SR, Ide YH, Shoji I, Hotta H.
- Journal Title
  
  Kobe J.Med.Sci. 56(2)
- NAID
  110007670723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790446
[Journal Article] Efficient production of infectious hepatitis C virus with adaptive mutations in cultured hepatoma cells2009
- Author(s)
  Bungyoku Y, Shoji I, Makine T, Adachi T, Hayashida K, Nagano-Fujii M, Ide Y, Deng L, Hotta H.
- Journal Title
  
  J. Gen. Virol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790339
[Journal Article] HCV replication suppresses cellular glucose uptake through down-regulation of cell surface expression of glucose transporters2009
- Author(s)
  Kasai D, Adachi T, Deng L, Nagano-Fujii M, Sada K, Ikeda M, Kato N, Ide YH, Shoji I, Hotta H.
- Journal Title
  
  J. Hepatol. 50(5)
  
  Pages: 883-894
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790339
[Journal Article] The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1.2009
- Author(s)
  Mohd-Ismail NK, Deng L, Sukumaran SK, Yu VC, Hotta H, Tan YJ.
- Journal Title
  
  J.Virol. 83(19)
  
  Pages: 9993-10006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790446
[Journal Article] Hepatitis C virus infection induces apoptosis through a Bax-triggered, mitochondrion-mediated. caspase-3-dependent pathway2008
- Author(s)
  Lin Deng
- Journal Title
  
  Journal of Virology 82
  
  Pages: 10375-10385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790339
[Journal Article] Hepatitis C virus infection induces apoptosis through a Bax-triggered, mitochondrion-mediated, caspase-3-dependent pathway2008
- Author(s)
  Deng L, Adachi T, Kitayama K, Bungyoku Y, Kitazawa S, Ishido S, Shoji I, Hotta H.
- Journal Title
  
  J. Virol. 82(21)
  
  Pages: 10375-10385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790339
[Presentation] HCV promotes the selective lysosomal degradation pathways, Chaperone-mediated autophagy and endosomal microautophagy, for viral proliferation2023
- Author(s)
  Matsui C, Septianastiti MA, Xu Z, Deng L, Abe T, Shoji I
- Organizer
  The 29th International Symposium on Hepatitis C Virus, Flaviviruses, and Related Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] 1.Oxidative stress sensor Keap1 recognizes HBx protein to activate Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication.2023
- Author(s)
  Deng L, Ariffianto A, Matsui C, Abe T, Ito M, Suzuki T, Matsuura Y, Shoji I.
- Organizer
  The 9th Japan-Taiwan-Korea HBV Research Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Oxidative stress sensor Keap1 recognizes HBx protein to activate Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication2023
- Author(s)
  Lin Deng, Adi Ariffianto, Takayuki Abe, Chieko Matsui, Masahiko Ito, Akihide Ryo, Hussein Hassan Aly, Koichi Watashi, Tetsuro Suzuki, Masashi Mizogami, Yoshiharu Matsuura and Ikuo Shoji
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Identification of DNA repair factors involved in HBV replication using a novel HBV reporter system.2023
- Author(s)
  Abe T, Nishitsuji H, Ito M, Aly H, Deng L, Matsui C, Shimotohno K, Shoji I.
- Organizer
  2023 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] A novel bile acid derivative inhibits hepatitis B virus infection by disrupting internalization of NTCP and PreS1 complexes at the entry step2023
- Author(s)
  GN Rsi Suwardana, Takayuki Abe, Daisuke Kuroki, Lin Deng, Chieko Matsui, Masafumi Ueda, Takashi Okitsu, Manabu Hatano, Kunitada Shimotohno, Ikuo Shoji
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] A novel bile acid derivative inhibits Hepatitis B Virus infection by disrupting internalization of NTCP and PreS1 complexes at the entry step.2023
- Author(s)
  Suwardana GR, Abe T, Kuroki D, Deng L, Matsui C, Ueda M, Okitsu T, Hatano M, Shimotohno K, Shoji I.
- Organizer
  2023 International HBV Meeting, 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication2023
- Author(s)
  Deng L, Ariffianto A, Abe T, Matsui C, Ito M, Ryo A, Aly HH, Watashi K, Suzuki T, Mizokami M, Matsuura Y, Shoji I.
- Organizer
  2023 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] 2.HERC5 E3 ligase mediates ISGylation of hepatitis B virus X protein (HBx) to promote viral replication.2023
- Author(s)
  Abe T, Bawono RG, Qu M, Kuroki D, Deng L, Matsui C, Ryo A, Suzuki T, Matsuura Y, Sugiyama M, Mizokami M, Shimotohno K, Shoji I.
- Organizer
  The 9th Japan-Taiwan-Korea HBV Research Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Oxidative stress sensor Keap1 recognizes HBx protein to activate Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication2022
- Author(s)
  Adi Ariffianto, Lin Deng, Chieko Matsui, Takayuki Abe, Masahiko Ito, Tetsuro Suzuki, Yoshiharu Matsuura, and Ikuo Shoji
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Oxidative Stress Sensor Keap1 Recognizes HBx protein to Activate Nrf2/ARE Signaling Pathway, thereby Inhibiting Hepatitis B Virus Replication2022
- Author(s)
  Lin Deng, Adi Ariffianto, Chieko Matsui, Takayuki Abe, Masahiko Ito, Tetsuro Suzuki, Yoshiharu Matsuura, and Ikuo Shoji
- Organizer
  2022 APASL Single Topic Conference on Hepatocellular Carcinoma (2022 APASL STC on HCC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Oxidative stress sensor Keap1 recognizes HBx protein to activate Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication2022
- Author(s)
  Lin Deng, Adi Ariffianto, Chieko Matsui, Takayuki Abe, Masahiko Ito, Tetsuro Suzuki, Yoshiharu Matsuura, and Ikuo Shoji
- Organizer
  2022 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] A novel bile acid derivative inhibits HBV infection via sodium taurocholate cotransporting polypeptide2022
- Author(s)
  GN Rsi Suwardana, Takayuki Abe, Kuroki Daisuke, Lin Deng, Chieko Matsui, Masafumi Ueda, Takahashi Okitsu, Manabu Hatano, Kunitada Shimotohno, Ikuo Shoji
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Annexin 5 is involved in the formation of tight junction integrity and negatively regulate HCV propagation.2021
- Author(s)
  Abe T, Matsui C, Deng L, Matsuura Y, Shoji I.
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] HCV-induced ROS/JNK signaling pathway activates the E3 ubiquitin ligase Itch to promote the release of HCV particles via polyubiquitylation of VPS4A.2021
- Author(s)
  Deng L, Liang Y, Ariffianto A, Matsui C, Abe T, Muramatsu M, Wakita T, Shibata H, Maki M, Shoji I.
- Organizer
  27th International Symposium on Hepatitis C Virus and Related Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Hepatitis C Virus Infection Promotes the Lysosomal Degradation of Diacylglycerol O-acyltransferase 1 (DGAT1).2021
- Author(s)
  Yuliandari P, Matsui C, Deng L, Abe T, Shoji I
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] 1.HCV-induced ROS/JNK signaling pathway activates the E3 ubiquitin ligase Itch to promote the release of HCV particles via polyubiquitylation of VPS4A.2021
- Author(s)
  Deng L, Liang Y, Ariffianto A, Matsui C, Abe T, Muramatsu M, Wakita T, Maki M, Shibata H, and Shoji I.
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Screening for anti-hepatitis B virus activities using heterocyclic compounds and HBV-NanoLuc reporter gene.2021
- Author(s)
  Abe T, Kuroki D, Matsui C, Deng L, Takeda N, Yasui M, Ueda M, Okitsu T, Yamano Y, Hatano M, Shimotohno K, Shoji I.
- Organizer
  2021 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] HCV NS3/4A protease cleaves SPG20 for formation of large lipid droplets.2021
- Author(s)
  Matsui C, Yuliandari P, Deng L, Abe T, Shoji I
- Organizer
  27th International Symposium on Hepatitis C Virus and Related Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Hepatitis B virus X protein activates Nrf2/ARE signaling pathway to suppress viral replication.2021
- Author(s)
  Deng L, Ariffianto A, Liang Y, Matsui C, Abe T, Matsuura Y, Shoji I
- Organizer
  17th ISVHLD GHS (Global Hepatitis Summit)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] HCV NS3/4A protease cleaves SPG20 for formation of large lipid droplets.2021
- Author(s)
  Matsui C, Yuliandari P, Deng L, Abe T, Shoji I.
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Activation of Nrf2/ARE signaling pathway upon hepatitis B virus infection inhibits viral replication.2021
- Author(s)
  Ariffianto A, Deng L, Liang Y, Matsui C, Abe T, Matsuura Y, and Shoji I.
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Hepatitis C Virus Infection Promotes the Lysosomal Degradation of Diacylglycerol O-acyltransferase 1 (DGAT1).2021
- Author(s)
  Yuliandari P, Matsui C, Deng L, Abe T, Shoji I
- Organizer
  27th International Symposium on Hepatitis C Virus and Related Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Screening for anti-hepatitis B virus activities using heterocyclic compounds and HBV-NanoLuc reporter gene.2021
- Author(s)
  Abe T, Kuroki D, Matsui C, Deng L, Takeda N, Yasui M, Ueda M, Okitsu T, Yamano Y, Hatano M, Shimotohno K, Shoji I.
- Organizer
  17th ISVHLD GHS (Global Hepatitis Summit)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Activation of Nrf2/ARE signaling pathway upon hepatitis B virus infection exerts an inhibitory effect on viral replication2021
- Author(s)
  Ariffianto A, Deng L, Liang Y, Matsui C, Abe T, Matsuura Y, and Shoji I.
- Organizer
  2021 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] Annexin 5 is involved in the formation of tight junction integrity and negatively regulate HCV propagation.2021
- Author(s)
  Abe T, Matsui C, Deng L, Matsuura Y, Shoji I
- Organizer
  27th International Symposium on Hepatitis C Virus and Related Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07040
[Presentation] HCV感染による糖代謝障害の分子機序2013
- Author(s)
  勝二郁夫、松井千絵子、DENG Lin、堀田博
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸、日本
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] HCV NS5A interacts with SMYD3 and upregulates SMYD3-mediated expression of AGR3 mRNA2013
- Author(s)
  Ming Chen, Xiang Gan, Lin Deng, Ikuo Shoji, Hak Hotta
- Organizer
  20th International Symposium on Hepatitis C Virus and Related Virus
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2013-10-07
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] Ｃ型肝炎ウイルス感染によるBax活性化の分子機序の解析2013
- Author(s)
  DENG Lin、陳明、勝二郁夫、堀田博
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸、日本
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] HCV NS5A interacts with SMYD3 and upregulates SMYD3-mediated expression of AGR3 mRNA2013
- Author(s)
  Ming Chen, Xiang Gan, Lin Deng, Ikuo Shoji, Hak Hotta
- Organizer
  20th Interantional Symposium on Hepatitis C Virus and Related Virus
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] Ｃ型肝炎ウイルス感染によるBax活性化の分子機序の解析2013
- Author(s)
  Lin Deng、陳　明、勝二郁夫、堀田博
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] Development of a prophylactic and therapeutic vaccine against Hepatitis C virus2013
- Author(s)
  Suratno Lulut Ratnoglik, Dapeng Jiang, Chie Aoki, Pratiwi Sudarmono, Lin Deng, Ikuo Shoji, Hak Hotta
- Organizer
  20th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] Regulation of hepatocyte nuclear factor 1α by hepatitis C virus NS5A protein2013
- Author(s)
  Chieko Matsui, Ikuo Shoji, Nanae Minami, Imelda Rosalyn Sianipar, Lin Deng, Hak Hotta
- Organizer
  20th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] HCV NS5AとHepatocyte nuclear factor (HNF) -1αの相互作用と病態生理2013
- Author(s)
  松井千絵子、勝二郁夫、南奈苗、Sianipar Imelda Rosalyn、 DENG Lin、堀田博
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸、日本
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] HCV upregulates Bim through ROS/JNK signaling pathway leading to Bax-mediated apoptosis2013
- Author(s)
  Lin Deng, Ming Chen, Ikuo Shoji, Hak Hotta
- Organizer
  20th International Symposium on Hepatitis C Virus and Related Virus
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2013-10-09
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] HCV upregulates Bim through ROS/JNK signaling pathway leading to Bax-mediated apoptosis2013
- Author(s)
  Lin Deng, Ming Chen, Ikuo Shoji, Hak Hotta
- Organizer
  20th Interantional Symposium on Hepatitis C Virus and Related Virus
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] C型肝炎ウイルス感染によるSmad1/Smad5経路の脱制御とその分子機序について2013
- Author(s)
  松岡陽子、朝日朱美、Deng Lin、勝二郁夫、堀田博
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸、日本
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] HCV NS5A interacts with SMYD3 and upregulates SMYD3-mediated expression of AGR3 mRNA2013
- Author(s)
  Ming Chen, Xiang Gan, Lin Deng, Ikuo Shoji, Hak Hotta
- Organizer
  20th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] HCV upregulates Bim through ROS/JNK signaling pathway leading to Bax-mediated apoptosis2013
- Author(s)
  Lin Deng, Ming Chen, Ikuo Shoji, Hak Hotta
- Organizer
  20th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] Antiviral activity of chlorophyll derivatives, pheophorbide a, chlorin e6 and mono-L-aspartyl chlorin e6 (NPe6), against hepatitis C virus2013
- Author(s)
  Hak Hotta, Chie Aoki, Suratno Lulut Ratnoglik, Pratiwi Sudarmono, Mari Komoto, Lin Deng, Ikuo Shoji, Hiroyuki Fuchino, Nobuo Kawahara
- Organizer
  20th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] C型肝炎ウイルス感染によるBax活性化の分子機序の解析2013
- Author(s)
  DENG Lin,陳明、勝二郁夫、堀田博
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2013-11-12
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] Development of therapeutic and preventive vaccines against Hepatitis C virus.2012
- Author(s)
  Jiang DP, Ratnoglik S L, Aoki C, Deng L, Shoji I, Hotta H.
- Organizer
  19th International Symposium on Hepatitis C Virus and Related Viruses.
- Place of Presentation
  Venice, Italy
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] Up-regulation of MAPK phosphatase 3 is involved in HCV-induced suppression of FoxO1 phosphorylation.2012
- Author(s)
  Deng L, Chen M, Jiang DP, Shoji I, Hotta H.
- Organizer
  19th International Symposium on Hepatitis C Virus and Related Viruses.
- Place of Presentation
  Venice, Italy
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] Ｃ型肝炎ウイルス感染によるBax活性化の分子機序の解析2012
- Author(s)
  DENG Lin、勝二郁夫、堀田博
- Organizer
  第65回日本細菌学会関西支部総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] Ｃ型肝炎ウイルス感染による転写因子FoxO1脱リン酸化の分子機序の解析2012
- Author(s)
  Lin Deng, 金子　昌裕、河本　真理、姜　大鵬、勝二　郁夫、堀田　博
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] C 型肝炎ウイルスNS5A 蛋白質のSrc homology 2/3 ドメイン結合能とB 細胞での発現によるSrc ファミリーキナーゼFyn の活性化2012
- Author(s)
  中島謙治,竹内健司,千原一泰,堀口朋子,孫雪東, Deng Lin,勝二郁夫,堀田博,定清直
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] C型肝炎ウイルスNS5A蛋白質の新規結合因子ヒストンメチル基転移酵素SMYD3の同定と機能解析2012
- Author(s)
  陳　明、甘　翔、DENG Lin、勝二　郁夫、堀田　博
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] Identification and characterization of a novel NS5A-interacting protein, SMYD3.2012
- Author(s)
  Chen M, Gan X, Deng L, Shoji I, Hotta H.
- Organizer
  19th International Symposium on Hepatitis C Virus and Related Viruses.
- Place of Presentation
  Venice, Italy
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] C 型肝炎ウイルス感染はHNF-1 αの発現を負に制御しGLUT2 遺伝子発現を抑制する2012
- Author(s)
  勝二郁夫, 松井千絵子, 兼田祟作, Imelda Rosalyn Sianipar, Deng Lin, 堀田博
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] C型肝炎ウイルス感染による転写因子FoxO1脱リン酸化の分子機序の解析2012
- Author(s)
  DENG Lin、金子昌裕、河本真理、姜大鵬、勝二郁夫、堀田博
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-11-13
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] Ｃ型肝炎ウイルス感染による転写因子FoxO1脱リン酸化の分子機序の解析2012
- Author(s)
  DENG Lin、金子　昌裕、河本　真理、姜　大鵬、勝二　郁夫、堀田　博
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] C型肝炎ウイルスNS5A蛋白質の新規結合因子ヒストンメチル基転移酵素SMYD3の同定と機能解析2012
- Author(s)
  陳明、甘翔、DENG Lin、勝二郁夫、堀田博
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-11-13
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] C型肝炎ウイルスに対する予防および治療ワクチン開発に関する研究2012
- Author(s)
  姜大鵬、Ratnoglik Lulut Suratno1、青木千恵、Deng Lin、勝二郁夫、堀田博
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] Up-regulation of MAPK phosphatase 3 is involved in HCV-induced suppression of FoxO1 phosphorylation2012
- Author(s)
  Lin Deng, Ming Chen, Dapeng Jiang, Ikuo Shoji, Hak Hotta
- Organizer
  19th International Symposium on Hepatitis C Virus and Related Virus
- Place of Presentation
  Venice, Italy
- Year and Date
  2012-10-06
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] C型肝炎ウイルス感染によるBax活性化の分子機序の解析2012
- Author(s)
  DENG Lin、勝二郁夫、堀田博
- Organizer
  第65回日本細菌学会関西支部総会
- Place of Presentation
  神戸
- Year and Date
  2012-11-17
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] Identification and characterization of a novel NS5A-interacting protein, SMYD32012
- Author(s)
  Ming Chen, Xiang Gan, Lin Deng, Ikuo Shoji, Hak Hotta
- Organizer
  19th International Symposium on Hepatitis C Virus and Related Virus
- Place of Presentation
  Venice, Italy
- Year and Date
  2012-10-07
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] C型肝炎ウイルスによるGLUT2遺伝子発現抑制の分子機構2012
- Author(s)
  松井千絵子、勝二郁夫、DENG Lin、堀田博
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] HCV infection induces lysosomal degradation of hepatocyte nuclear factor 1α via interaction with HCV NS5A protein.2012
- Author(s)
  Matsui C, Shoji I, Deng L, Hotta H.
- Organizer
  19th International Symposium on Hepatitis C Virus and Related Viruses.
- Place of Presentation
  Venice, Italy
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] Hepatitis C Virus Infection Promotes Hepatic Gluconeogenesis through an NS5A-Mediated, FoxO1-Dependent Pathway2011
- Author(s)
  Lin Deng, Ikuo Shoji, Wataru Ogawa, Shusaku Kaneda, Tomoyoshi Soga, Da-peng Jiang, Yoshi-Hiro Ide, Hak Hotta
- Organizer
  18th International Symposium on Hepatitis C Virus and Related Virus
- Place of Presentation
  Seattle, USA
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] C型肝炎ウイルスNS5Aの新規結合タンパク質であるヒストンメチル基転移酵素SMYD3の同定2011
- Author(s)
  甘翔、DENG Lin、陳明、井出良浩、勝二郁夫、堀田博
- Organizer
  第64回日本細菌学会関西支部総会
- Place of Presentation
  大阪府堺市
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] C型肝炎ウイルスは酸化ストレスを介して糖新生を亢進し糖尿病発症に関与する2011
- Author(s)
  DENG Lin、勝二郁夫、堀田博
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] C型肝炎ウイルスNS5Aの新規結合タンパク質であるヒストンメチル基転移酵素SMYD3の同定2011
- Author(s)
  Lin Deng
- Organizer
  第64回日本細菌学会関西支部総会
- Place of Presentation
  大阪府　堺市
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] Molecular mechanisms involved in HCV infection-induced hepatic gluconeogenesis2011
- Author(s)
  Lin Deng, Ikuo Shoji, Wataru Ogawa, Shusaku Kaneda, Tomoyoshi Soga, Da-peng Jiang, Yoshi-Hiro Ide, Hak Hotta
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  札幌
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] HCV-induced generation of reactive oxygen species leads to Bax-mediated apoptosis through activation of the c-Jun NH_2-terminal kinase signaling pathway2010
- Author(s)
  Lin Deng
- Organizer
  17^<th> international symposium on hepatitis c virus & related virus
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-21790446
[Presentation] 糖代謝に及ぼすC型肝炎ウイルスの影響及びその分子機序の解析2010
- Author(s)
  Lin Deng
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島県郷土文化会館(徳島県)
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21790446
[Presentation] 糖代謝に及ぼすC型肝炎ウイルスの影響及びその分子機序の解析2010
- Author(s)
  Deng Lin、兼田崇作、井出良浩、勝二郁夫、堀田博
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21790446
[Presentation] HCV-induced generation of reactive oxygen species leads to Bax-mediated apoptosis through activation of the c-Jun NH_2-terminal kinase signaling pathway.2010
- Author(s)
  Deng L, Ide YH, Shoji I, Hotta H.
- Organizer
  17^<th> international symposium on hepatitis c virus & related virus
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-21790446
[Presentation] C型肝炎ウイルス感染は転写因子FoxO1を介した糖新生を誘導する2010
- Author(s)
  Deng Lin、兼田崇作、井出良浩、勝二郁夫、堀田博
- Organizer
  第63回日本細菌学会関西支部総会
- Place of Presentation
  枚方
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21790446
[Presentation] C型肝炎ウイルス感染によるBax活性化の分子機序の解析2009
- Author(s)
  Deng Lin、井出良浩、勝二郁夫、堀田博
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  東京
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-21790446
[Presentation] Activation of JNK, but not p38 MAPK, is involved in HCV-induced, Bax-mediated apoptosis2009
- Author(s)
  Lin Deng
- Organizer
  16^<th> international symposium on hepatitis c virus & related virus
- Place of Presentation
  Nice, France
- Year and Date
  2009-10-04
- Data Source
  KAKENHI-PROJECT-21790446
[Presentation] Activation of JNK, but not p38 MAPK, is involved in HCV-induced, Bax-mediated apoptosis.2009
- Author(s)
  Deng L, Ide YH, Shoji I, Hotta H.
- Organizer
  16^<th> international symposium on hepatitis c virus & related virus
- Place of Presentation
  Nice, France
- Year and Date
  2009-10-04
- Data Source
  KAKENHI-PROJECT-21790446
[Presentation] C型肝炎ウイルス感染によるBax活性化の分子機序の解析2009
- Author(s)
  Lin Deng
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  都市センターホテル(東京都)
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-21790446
[Presentation] HCV infection induces Bax-triggered, mitochondria-mediated, caspase-3-dependent apoptosis2008
- Author(s)
  Deng L, Adachi T, Kitayama K, Bungyoku Y, Kitazawa S, Ishido S, Shoji I, Hotta H.
- Organizer
  15^<th> international symposium on hepatitis c virus & related virus
- Place of Presentation
  San Antonio, USA
- Year and Date
  2008-10-07
- Data Source
  KAKENHI-PROJECT-19790339
[Presentation] C型肝炎ウイルス感染によるアポトーシスの分子機序の解析2008
- Author(s)
  Deng Lin, 足達哲也, 北山喜九美, 分玉泰彰, 北澤荘平, 石戸総, 勝二郁夫, 堀田博
- Organizer
  第56回日本ウイルス学会学術集会
- Place of Presentation
  岡山
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-19790339
[Presentation] C型肝炎ウイルス感染による細胞変性効果の分子機序の解析2007
- Author(s)
  Deng Lin, 長野基子, 北山喜九美, 安春英, 分玉泰彰, 堀田博
- Organizer
  第55回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2007-10-22
- Data Source
  KAKENHI-PROJECT-19790339
[Presentation] Hepatitis C virus infection induces apoptosis via a mitochondrial-related caspase pathway2007
- Author(s)
  Deng L, Nagano-Fujii M, Kitayama K, An C, Bungyoku Y, Hotta H.
- Organizer
  14^<th> international symposium on hepatitis c virus & related virus
- Place of Presentation
  Glasgow, United Kingdom
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-19790339
[Presentation] Hepatitis C virus infection induces apoptosis via a mitochondrial-related caspase pathway2007
- Author(s)
  DENG LIN
- Organizer
  I4^th international symposium on hepatitis c viras & related virus
- Place of Presentation
  Glasgow, United Kingdom
- Year and Date
  2007-11-09
- Data Source
  KAKENHI-PROJECT-19790339
[Presentation] Ｃ型肝炎ウイルスによるミトコンドリア介在性アポトーシス誘導機構の解明.
- Author(s)
  甘翔, DENG Lin, 陳明, 勝二郁夫, 堀田博
- Organizer
  第62回日本ウイルス学会学術集会.
- Place of Presentation
  横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] HCV dysregulates Smad2/3- and Smad1/5-signaling pathways of the TGF-β superfamily.
- Author(s)
  Matsuoka Y, Deng L, Asahi A, Aoki C, Shoji I, Hotta H
- Organizer
  21st International Symposium on Hepatitis C Virus and Related Viruses.
- Place of Presentation
  Banff, Canada
- Year and Date
  2014-09-07 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] C型肝炎ウイルス感染によるTGF-βスーパーファミリーにおけるSmad2/3とSmad1/5/9経路の脱制御とその分子機序の解明.
- Author(s)
  松岡陽子, DENG Lin, 朝日朱美, 青木千恵, 勝二郁夫, 堀田博
- Organizer
  第62回日本ウイルス学会学術集会.
- Place of Presentation
  横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] hysical and functional interaction between an OTU deubiquitinase and HCV NS5A protein.
- Author(s)
  Sianipar I R, Shoji I, Matsui C, Minami N, Deng L, Hotta H
- Organizer
  The 21st International Symposium on Hepatitis C Virus and Related Viruses.
- Place of Presentation
  Banff, Canada
- Year and Date
  2014-09-07 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] HCV NS5A interacts with lysine methyltransferase SMYD3 and transcriptionally activates the protein disulfide isomerase gene AGR3.
- Author(s)
  Chen M, Gan X, Deng L, Shoji I, Hotta H
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] HCV induces Bim/Bax-mediated apoptosis through the ROS/JNK signaling pathway.
- Author(s)
  Deng L, Chen M, Shoji I, Hotta H
- Organizer
  The 21st International Symposium on Hepatitis C Virus and Related Viruses.
- Place of Presentation
  Banff, Canada
- Year and Date
  2014-09-07 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] Determinants of specific interaction between hepatitis C virus NS5A and HNF-1α protein.
- Author(s)
  Matsui C, Shoji I, Sianipar I R, Minami N, Deng L, Hotta H
- Organizer
  The 21st International Symposium on Hepatitis C Virus and Related Viruses.
- Place of Presentation
  Banff, Canada
- Year and Date
  2014-09-07 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] Ｃ型肝炎ウイルス感染によるBax活性化の分子機序の解析
- Author(s)
  Lin Deng, 勝二郁夫、堀田博
- Organizer
  第65回日本細菌学会関西支部総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590543
[Presentation] HCV NS5A protein physically and functionally interacts with an OTU deubiquitinase.
- Author(s)
  Sianipar IR, Shoji I, Matsui C, Minami N, Deng L, Hotta H
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] C型肝炎ウイルス感染によるHepatocyte nuclear factor (HNF) -1α蛋白質の選択的分解機構
- Author(s)
  松井千絵子, 勝二郁夫, Sianipar I R, 南奈苗, DENG Lin, 堀田博
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24590976
[Presentation] C型肝炎ウイルスによるHNF-1α蛋白質の選択的分解機構の解析.
- Author(s)
  勝二郁夫, 松井千絵子, Imelda Rosalyn Sianipar, 南奈苗, Lin Deng, 堀田博
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24590976

1. HOTTA Hak (40116249)

# of Collaborated Projects: 2 results

# of Collaborated Products: 58 results
2. SHOJI Ikuo (40356241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 38 results
3. 井出良浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 松井千絵子

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
5. 脇田隆字

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 斎藤貴史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

DENG LIN デン リン

Deng Lin デン リン

DENG Lin デン リン

Research Projects

Research Products

Co-Researchers

Analysis of the effect of Nrf2-Prdx1 pathway on the degradation of hepatitis B virus RNAPrincipal Investigator

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Review Section

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Study on molecular mechanisms of glucose metabolic disorders mediated by hepatitis C virus

Principal Investigator

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Study on the mechanisms of HCV-mediated carcinogenesisPrincipal Investigator

Principal Investigator

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Research Institution

Study on the mechanism of hepatitis C virus infection-induced apoptosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the mechanism of hepatitis C virus infection-induced cytopathic effectPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Transcription Factor JunB Suppresses Hepatitis C Virus Replication2023

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[Journal Article] Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal Pathways2023

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[Journal Article] Hepatitis C Virus Disrupts Annexin 5-Mediated Occludin Integrity through Downregulation of Protein Kinase Cα (PKCα) and PKCη Expression, Thereby Promoting Viral Propagation2023

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[Journal Article] Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication2023

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DOI

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[Journal Article] Complete genome analyses of G12P[8] rotavirus strains from hospitalized children in Surabaya, Indonesia, 2017-20182023

Author(s)

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[Journal Article] A household survey of intrafamily norovirus transmission2023

Author(s)

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[Journal Article] Hepatitis C virus NS5A protein promotes the lysosomal degradation of diacylglycerol O-acyltransferase 1 (DGAT1) via endosomal microautophagy2022

Author(s)

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DOI

Data Source

[Journal Article] Hepatitis C Virus-Induced ROS/JNK Signaling Pathway Activates the E3 Ubiquitin Ligase Itch to Promote the Release of HCV Particles via Polyubiquitylation of VPS4A2022

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[Journal Article] HERC5 E3 ligase mediates ISGylation of hepatitis B virus X protein to promote viral replication2021

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DENG LIN デンリン

Deng Lin デンリン

DENG Lin デンリン