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Shimura Tsutomu  志村 勉

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SHIMURA Tsutomu  志村 勉

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Researcher Number 40463799
Other IDs
Affiliation (Current) 2019: 国立保健医療科学院, その他部局等, 上席主任研究官
Affiliation (based on the past Project Information) *help 2016 – 2019: 国立保健医療科学院, その他部局等, 上席主任研究官
2015 – 2017: 国立保健医療科学院, 生活環境研究部, 上席主任研究官
2013 – 2015: 国立保健医療科学院, その他部局等, その他
2012 – 2013: 国立保健医療科学院, 生活環境研究部, 上席主任研究官
2008 – 2010: Tohoku University, 加齢医学研究所, 助教
2009: 東北大, 加齢医学研究所, 助教
Review Section/Research Field
Principal Investigator
Risk sciences of radiation/Chemicals / Environmental impact assessment / Basic Section 63020:Radiation influence-related / Health science and related fields
Except Principal Investigator
Experimental pathology / Risk sciences of radiation and chemicals
Keywords
Principal Investigator
放射線 / がん / ミトコンドリア / 酸化ストレス / 低線量放射線 / 放射線発がん / がんの微小環境 / 微小環境 / 放射線耐性 / 活性酸素 … More / サイクリンD1 / AKT / ストレス応答 / 発がん / ROS … More
Except Principal Investigator
臨床的放射線耐性 / がん細胞 / ミトコンドリア / ワールブルグ効果 / 活性酸素種(ROS) / X線 / ドセタキセル / カタラーゼ / 電子伝達系 / 活性酸素 / 生物影響 / 低レベル放射線 / 微小循環 / 生体顕微鏡 / 酸化ストレス / 循環器系 Less
  • Research Projects

    (8 results)
  • Research Products

    (68 results)
  • Co-Researchers

    (34 People)
  •  Study of biological effects of ionizing radiation on mitochondriaPrincipal InvestigatorOngoing

    • Principal Investigator
      志村 勉
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 63020:Radiation influence-related
    • Research Institution
      National Institute of Public Health
  •  放射線によるがん関連線維芽細胞の形成と放射線発がんへの関与Principal InvestigatorOngoing

    • Principal Investigator
      志村 勉
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Challenging Research (Exploratory)
    • Research Field
      Health science and related fields
    • Research Institution
      National Institute of Public Health
  •  The study on the low dose radiation on oxidative stress and cardiovascular systems on maice

    • Principal Investigator
      USHIYAMA Akira
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      National Institute of Public Health
  •  Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in low-dose irradiated human fibroblastsPrincipal Investigator

    • Principal Investigator
      Shimura Tsutomu
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Environmental impact assessment
    • Research Institution
      National Institute of Public Health
  •  Eradication of radioresistant cancer stem cells by inhibiting the AKT survival signaling pathway.Principal Investigator

    • Principal Investigator
      SHIMURA Tsutomu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      National Institute of Public Health
  •  New developments in mitochondrial study to overcome

    • Principal Investigator
      FUKUMOTO MANABU
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Tohoku University
  •  Analysis of the molecular mechanisms of acquired radioresistance induced by fractionated radiationPrincipal Investigator

    • Principal Investigator
      SHIMURA Tsutomu
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Tohoku University
  •  G1サイクリンを標的とした長期放射線被ばくマーカーの同定と有効な放射線療法の確立Principal Investigator

    • Principal Investigator
      志村 勉
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Tohoku University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

  • [Journal Article] Lessons learned from radiation biology: Health effects of low levels of exposure to ionizing radiation on humans regarding the Fukushima accident.2018

    • Author(s)
      Shimura Tsutomu, Yamaguchi Ichiro, Terada Hiroshi, Kunugita Naoki.
    • Journal Title

      Journal of the National Institute of Public Health

      Volume: 67 Pages: 115-122

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19944
  • [Journal Article] Lessons learned from radiation risk communication activities regarding the Fukushima nuclear accident.2018

    • Author(s)
      Yamaguchi Ichiro, Shimura Tsutomu, Terada Hiroshi, Svendsen Erik.R., Kunugita Naoki
    • Journal Title

      Journal of the National Institute of Public Health

      Volume: 67 Pages: 93-102

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19944
  • [Journal Article] Regulation values and current situation of radioactive materials in food.2018

    • Author(s)
      Terada Hiroshi, Yamaguchi Ichiro, Shimura Tsutomu, Svendsen Erik.R., Kunugita Naoki.
    • Journal Title

      Journal of the National Institute of Public Health

      Volume: 67 Pages: 21-33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19944
  • [Journal Article] Tokyo Electric Power Company Fukushima Dai-ichi Nuclear Power Plant accident and public health.2018

    • Author(s)
      Kunugita Naoki, Shimura Tsutomu, Terada Hiroshi, Yamaguchi Ichiro.
    • Journal Title

      Journal of the National Institute of Public Health

      Volume: 67 Pages: 2-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19944
  • [Journal Article] Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level.2017

    • Author(s)
      Kamiya K, Sasatani M, Xi Y, Kajimura J, Kawamura T, Piao J, Masuda Y, Honda H, Kubo K, Mikamoto T, Watanabe H, Xu Y, Kawai H, Shimura T, Noda A, Hamasaki K, Kusunoki Y, Zaharieva E.
    • Journal Title

      Carcinogenesis

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K12220
  • [Journal Article] Targeting the AKT/cyclin D1 pathway to overcome intrinsic and acquired radioresistance of tumors for effective radiotherapy2017

    • Author(s)
      Shimura T
    • Journal Title

      International Journal of Radiation Biology

      Volume: 93 Pages: 381-385

    • DOI
      10.1080/09553002.2016.1257832
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-17K19944
  • [Journal Article] A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells.2017

    • Author(s)
      Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N.
    • Journal Title

      Cell Cycle

      Volume: 16 Pages: 565-573

    • DOI
      10.1080/15384101.2017.1284716
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26241013, KAKENHI-PROJECT-15H02819, KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-16K00547
  • [Journal Article] Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level2017

    • Author(s)
      Sasatani M, Xi Y, Kajimura J, Kawamura T, Piao J, Masuda Y, Honda H, Kubo K, Mikamoto T, Watanabe H, Xu Y, Kawai H, Shimura T, Noda A, Hamasaki K, Kusunoki Y, Zaharieva EK, Kamiya K.
    • Journal Title

      Carcinogenesis

      Volume: 38(5) Pages: 570-578

    • DOI
      10.1093/carcin/bgw208
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K00547, KAKENHI-PROJECT-17K00553, KAKENHI-PROJECT-17K19944, KAKENHI-PROJECT-15H02818, KAKENHI-PROJECT-16K12594
  • [Journal Article] ATM-mediated mitochondrial damage response triggered by nuclear DNA damage in normal human lung fibroblasts2017

    • Author(s)
      Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N.
    • Journal Title

      Cell Cycle

      Volume: 16(24) Pages: 2345-2354

    • DOI
      10.1080/15384101.2017.1387697
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K00547, KAKENHI-PROJECT-17K00553, KAKENHI-PROJECT-17K19944, KAKENHI-PROJECT-26241013, KAKENHI-PROJECT-15H02819, KAKENHI-PROJECT-17H06284
  • [Journal Article] ミトコンドリアの放射線応答と放射線発がんへの影響2017

    • Author(s)
      志村勉、欅田尚樹
    • Journal Title

      放射線生物研究

      Volume: 52 Pages: 183-193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19944
  • [Journal Article] Mitochondrial reactive oxygen species-mediated genomic instability in low-dose irradiated human cells through nuclear retention of cyclin D12016

    • Author(s)
      Shimura T and Kunugita N
    • Journal Title

      Cell Cycle

      Volume: 15 Pages: 1410-1414

    • DOI
      10.1080/15384101.2016.1170271
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K12220
  • [Journal Article] Severe mitochondrial damage associated with low-dose radiation sensitivity in ATM- and NBS1-deficient cells.2016

    • Author(s)
      Shimura T, Kobayashi J, Komatsu K, Kunugita N.
    • Journal Title

      Cell Cycle

      Volume: 15 Pages: 1099-1107

    • DOI
      10.1080/15384101.2016.1156276
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-26241013, KAKENHI-PROJECT-15H02819
  • [Journal Article] SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair.2016

    • Author(s)
      Akita M
    • Journal Title

      Sci Rep.

      Volume: 5 Pages: 10984-10984

    • DOI
      10.1038/srep10984
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K12203, KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-15K14953, KAKENHI-PROJECT-26550042, KAKENHI-ORGANIZER-22131001, KAKENHI-PLANNED-23116008, KAKENHI-PUBLICLY-26116517, KAKENHI-PROJECT-26870356, KAKENHI-PROJECT-26281020, KAKENHI-PROJECT-15H04646
  • [Journal Article] Systematic protein level regulation via degradation machinery induced by genotoxic drugs2016

    • Author(s)
      Kume K, Ishida K, Ikeda M, Takemoto K, Shimura T, Young L, Nishizuka SS.
    • Journal Title

      Journal of Proteome Research

      Volume: 15 Pages: 205-15

    • DOI
      10.1021/acs.jproteome.5b00759
    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10114, KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-25462034, KAKENHI-PROJECT-25700030
  • [Journal Article] Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in low dose irradiated human fibroblasts.2016

    • Author(s)
      Shimura T, Sasatani M, Kamiya K, Kawai H, Inaba Y, Kunugita N.
    • Journal Title

      Oncotarget

      Volume: 7 Pages: 3559-3570

    • DOI
      10.18632/oncotarget.6518
    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-25340033, KAKENHI-PROJECT-25340032, KAKENHI-PROJECT-25281020
  • [Journal Article] Wilms' tumor gene WT1 promotes homologous recombination-mediated DNA damage repair.2015

    • Author(s)
      Oji Y, Kobayashi J, et al.
    • Journal Title

      Mol Carcinog.

      Volume: in press Pages: 1758-1771

    • DOI
      10.1002/mc.22248
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24310041, KAKENHI-PROJECT-24510063, KAKENHI-PROJECT-24591395, KAKENHI-PUBLICLY-25112513, KAKENHI-PROJECT-25460685, KAKENHI-PROJECT-26241013, KAKENHI-PROJECT-26550025, KAKENHI-PROJECT-15K09476
  • [Journal Article] Radiation Occupational Health Interventions Offered to Radiation Workers in Response to the Complex Catastrophic Disaster at the Fukushima Daiichi Nuclear Power Plant.2015

    • Author(s)
      Shimura T, Yamaguchi I, Terada H, Okuda K, Svendsen E.R., Kunugita N.
    • Journal Title

      J Radiat Res

      Volume: 56 Pages: 413-421

    • DOI
      10.1093/jrr/rru110
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Journal Article] Downregulation of miRNA-31 induces taxane resistance in ovarian cancer cells through increase of receptor tyrosine kinase MET.2015

    • Author(s)
      Shimura T, Kobayashi J, Komatsu K, Kunugita N.
    • Journal Title

      Oncogenesis

      Volume: 3

    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24510063, KAKENHI-PROJECT-24590406
  • [Journal Article] Public Health Activities for Mitigation of Radiation Exposures and Risk Communication Challenges after the Fukushima Nuclear Accident Journal of Radiation Research2015

    • Author(s)
      Shimura T, Yamaguchi I, Terada H, Kengo O, Svendsen E.R., Kunugita N.
    • Journal Title

      J Radiat Res

      Volume: 56 Pages: 422-429

    • DOI
      10.1093/jrr/rrv013
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Journal Article] Efficiency of Excess Monitoring for Beef after the Fukushima Accident2015

    • Author(s)
      Shimura T, Yamaguchi I, Terada H, Yunokawa T, Svendsen E.R., Kunugita N.
    • Journal Title

      Food Safety

      Volume: 3 Issue: 3 Pages: 84-91

    • DOI
      10.14252/foodsafetyfscj.2015018
    • ISSN
      2187-8404
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K12220
  • [Journal Article] RAD18 activates the G2/M checkpoint through DNA damage signaling to maintain genome integrity after ionizing radiation exposure2015

    • Author(s)
      Sasatani M, Xu Y, Kawai H, Cao L, Tateishi S, Shimura T, Li J, Iizuka D, Noda A, Hamasaki K, Kusunoki Y, Kamiya K.
    • Journal Title

      Plos One

      Volume: 10 Pages: 1-16

    • DOI
      10.1371/journal.pone.0117845
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24510063, KAKENHI-PUBLICLY-25131715, KAKENHI-PROJECT-25340032, KAKENHI-PROJECT-25550031, KAKENHI-PROJECT-26340024, KAKENHI-PROJECT-25220102, KAKENHI-PROJECT-25281020
  • [Journal Article] The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage.2015

    • Author(s)
      Fu H, Martin M, Regairaz M, Huang L, You Y, Lin C, Ryan M, Kim R, Shimura T, Pommier Y, Aladjem M.
    • Journal Title

      Nature Communications

      Volume: 6

    • DOI
      10.1038/ncomms7746
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K12220
  • [Journal Article] 長期放射線被爆とサイクリンD12014

    • Author(s)
      志村勉、欅田尚樹
    • Journal Title

      生体の科学

      Volume: 65 Pages: 176-181

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Journal Article] Nuclear accumulation of cyclin D1 following long-term fractionated exposures to low-dose ionizing radiation in normal human diploid cells2014

    • Author(s)
      Shimura T, Hamada N, Sasatani M, Kamiya K, Kunugita N
    • Journal Title

      Cell cycle

      Volume: 13 Pages: 1248-1255

    • DOI
      10.4161/cc.28139
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510063, KAKENHI-PROJECT-25281020, KAKENHI-PROJECT-25340032, KAKENHI-PROJECT-25550031
  • [Journal Article] Nuclear accumulation of cyclin D1 following long-term fractionated exposures to low-dose ionizing radiation in normal human diploid cells.2014

    • Author(s)
      Shimura T, Hamada N, Sasatani M, Kamiya K, Kunugita N.
    • Journal Title

      Cell Cycle

      Volume: 13 Pages: 1248-55

    • Acknowledgement Compliant / Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Journal Article] AKT-mediated enhanced aerobic glycolysis causes acquired radioresistance by human tumor cells.2014

    • Author(s)
      Shimura T, Noma N, Sano Y, Ochiai Y, Oikawa T, Fukumoto M, Kunugita N.
    • Journal Title

      Radiotherapy and Oncology

      Volume: 112 Pages: 302-307

    • Acknowledgement Compliant / Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Journal Article] 長期放射線被ばくによるサイクリンD1 発現制御の破綻2013

    • Author(s)
      志村勉、野間直十、佐野由衣、落合泰史、及川利幸、角田智、福本学、欅田尚樹
    • Journal Title

      放射線生物研究

      Volume: 48 Pages: 323-335

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Journal Article] Distribution of artificial radionuclides in abandoned cattle in the evacuation zone of the Fukushima Daiichi Nuclear Power Plant.2013

    • Author(s)
      Fukuda T, Kino Y, Abe Y, Yamashiro H, Kuwahara Y, Nihei H, Sano Y, Irisawa A, Shimura T, Fukumoto M, Shinoda H, Obata Y, Saigusa S, Sekine T, Isogai E, Fukumoto M.
    • Journal Title

      PLoS One.

      Volume: 8(1) Pages: 1-7

    • DOI
      10.1371/journal.pone.0054312
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23710066, KAKENHI-PROJECT-23780278, KAKENHI-PROJECT-24510063, KAKENHI-PROJECT-24659174, KAKENHI-PROJECT-25340026
  • [Journal Article] 放射線生物学から見た低線量放射線の生体影響2013

    • Author(s)
      志村勉
    • Journal Title

      保健医療科学

      Volume: 62 Pages: 189-195

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Journal Article] The role of cyclin D1 in response to long-term exposure to ionizing radiation2013

    • Author(s)
      Shimura T, Fukumoto M, Kunugita N
    • Journal Title

      Cell Cycle

      Volume: 12 Pages: 2738-2743

    • DOI
      10.4161/cc.25746
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510063, KAKENHI-PROJECT-24659174
  • [Journal Article] Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells.2013

    • Author(s)
      Shimura T, Ochiai Y, Noma N, Oikawa T, Sano Y, Fukumoto M.
    • Journal Title

      Cell Cycle

      Volume: 12 Pages: 773-82

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Journal Article] Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells2013

    • Author(s)
      Shimura T , Ochiai Y, Noma N, Oikawa T, Sano Y, Fukumoto M.
    • Journal Title

      Cell Cycle

      Volume: 1;12(5) Pages: 773-82

    • DOI
      10.4161/cc.23719
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659174
  • [Journal Article] Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells.2012

    • Author(s)
      Shimura T, Noma N, Oikawa T, Ochiai Y, Kakuda S, Kuwahara Y, Takai Y, Takahashi A, Fukumoto M.
    • Journal Title

      Oncogenesis

      Volume: 8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Journal Article] Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells2012

    • Author(s)
      Shimura T, Noma N, Oikawa T, Ochiai Y, Kakuda S, Kuwahara Y, Takai Y, Fukumoto M.
    • Journal Title

      Oncogenesis

      Volume: 1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659174
  • [Journal Article] Interactions of MCP1 with Components of the Replication Machinery in Mammalian Cells2011

    • Author(s)
      Bronze-da-Rocha E, Lin CM, Shimura T, Aladjem MI.
    • Journal Title

      Int J Biol Sci

      Volume: 7 Pages: 193-208

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Journal Article] Targeting the AKT/GSK3beta/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radio therapy2011

    • Author(s)
      Shimura T, et al.
    • Journal Title

      International Journal of Radiation Oncology Biology Physics

      Volume: (未定 印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Journal Article] Interactions of MCP1 with Components of the Replication Machinery in Mammalian Cells.2011

    • Author(s)
      Bronze-da-Rocha E, Lin CM, Shimura T, Aladjem MI.
    • Journal Title

      Int J Biol Sci 7

      Pages: 193-208

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Journal Article] Targeting the AKT/GSK3b/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy2011

    • Author(s)
      Shimura T, Kakuda S, Ochiai Y, Kuwahara Y, Takai Y, Fukumoto M.
    • Journal Title

      International Journal of Radiation Oncology Biology Physics 80

      Pages: 540-548

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Journal Article] Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpression.2010

    • Author(s)
      Shimura T, et al.
    • Journal Title

      Oncogene

      Volume: 29 Pages: 4826-4837

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Journal Article] The modified high-density survival assay is the useful tool to predict the effectiveness of fractionated radiation exposure.2010

    • Author(s)
      Kuwahara Y, Mori M, Oikawa T, Shimura T, Ohtake Y, Mori S, Ohkubo Y, Fukumoto M.
    • Journal Title

      J Radiat Res (Tokyo) 51

      Pages: 297-302

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Journal Article] Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpression.2010

    • Author(s)
      Shimura T, Kakuda S, Ochiai Y, Nakagawa H, Kuwahara Y, Takai Y, Kobayashi J, Komatsu K, Fukumoto M.
    • Journal Title

      Oncogene 29

      Pages: 4826-4837

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Journal Article] X-radiation-induced down-regulation of the EGF receptor in primary cultured rat hepatocytes.2010

    • Author(s)
      Maruko A, Ohtake Y, Kawaguchi M, Kobayashi T, Baba T, Kuwahara Y, Nakagawa H, Shimura T, Fukumoto M, Ohkubo Y.
    • Journal Title

      Radiat Res 173

      Pages: 620-628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Journal Article] Clinically relevant radioresistant cells efficiently repair DNA double-strand breaks induced by X-rays.2009

    • Author(s)
      Kuwahara Y, Li L, Baba T, Nakagawa H, Shimura T, Yamamoto Y, Ohkubo Y, Fukumoto M.
    • Journal Title

      Cancer Sci 100

      Pages: 747-752

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Journal Article] Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress2008

    • Author(s)
      Tsutomu Shimura
    • Journal Title

      Journal of Molecular Biology 375

      Pages: 1152-1164

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20810003
  • [Presentation] Radiation-induced mitochondrial damage in neural progenitor stem cells and differentiated cells.2018

    • Author(s)
      Shimura Tsutomu and Kunugita Naoki
    • Organizer
      The 8th Annual Meeting of the International Society of Radiation Neurobiology.
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-17K19944
  • [Presentation] A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells.2017

    • Author(s)
      Shimura T, Sasatani M, Kawai H, Kamiya K and Kunugita N.
    • Organizer
      The 1st international symposium of the network-type joint usage/research center for radiation disaster medical science
    • Place of Presentation
      広島
    • Year and Date
      2017-02-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K12220
  • [Presentation] A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells.2017

    • Author(s)
      Shimura Tsutomu, Sasatani Megumi, Kawai Hidehiko, Kamiya Kenji, Kunugita Naoki.
    • Organizer
      The 1st international symposium of the network-type joint usage/research center for radiation disaster medical science.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19944
  • [Presentation] ATMが制御する核とミトコンドリアの放射線応答2017

    • Author(s)
      志村勉、笹谷めぐみ、河合秀彦、神谷研二、小林純也、小松賢志、欅田尚樹
    • Organizer
      第60回日本放射線影響学会
    • Data Source
      KAKENHI-PROJECT-17K19944
  • [Presentation] 低線量長期放射線照射におけるミトコンドリア由来活性酸素の蓄積と酸化ストレスによる細胞周期制御機構への影響2016

    • Author(s)
      志村勉、笹谷めぐみ、河合秀彦、神谷研二、欅田 尚樹.
    • Organizer
      第59回日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-15K12220
  • [Presentation] Mitochondrial DNA damage responses in ATM- and NBS1-deficient cells.2016

    • Author(s)
      Shimura T, Kobayashi J, Komatsu K, Kunugita N.
    • Organizer
      第59回日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-15K12220
  • [Presentation] DNA damage signaling guards against perturbation of cyclin D1 expression by low-dose long-term fractionated radiation.2015

    • Author(s)
      Tsutomu Shimura, Junya Kobayashi, Kenshi Komatsu, Naoki Kunugita.
    • Organizer
      15th International congress of radiation research
    • Place of Presentation
      京都
    • Year and Date
      2015-05-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K12220
  • [Presentation] Cyclin D1 as a molecular marker and possible molecular radioprotection target for long-term exposure to low-dose ionizing radiation2014

    • Author(s)
      Tsutomu Shimura, Megumi Sasatani, Kenji Kamiya, Nobuyuki Hamada, Naoki Kunugita
    • Organizer
      The 4th International Symposium Hiroshima-Nagasaki collaborative research on radiation disaster medicine
    • Place of Presentation
      hirosima
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Presentation] 低線量長期放射線によるサイクリンD1発現制御の破綻2013

    • Author(s)
      志村 勉、笹谷めぐみ、神谷研二、浜田信行、欅田 尚樹
    • Organizer
      第56回日本放射線影響学会
    • Place of Presentation
      青森
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Presentation] Eradication of radioresistant tumors by inhibiting the AKT survival signaling pathway2013

    • Author(s)
      Tsutomu Shimura, Naoto Noma, Toshiyuki Oikawa, Yasushi Ochiai, Yui Sano, Satoshi Kakuda, Manabu Fukumoto
    • Organizer
      3rd International symposium Biological effects of low dose radiation
    • Place of Presentation
      Hiroshima
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Presentation] 低線量放射線に対するサイクリンD1の応答の解析2012

    • Author(s)
      志村勉、桑原 義和、福本 学、寺田 宙、欅田 尚樹
    • Organizer
      第55回日本放射線影響学会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Presentation] Eradication of radioresistant tumors by inhibiting the AKT survival signaling pathway.2012

    • Author(s)
      Tsutomu Shimura, Naoto Noma, Toshiyuki Oikawa, Yasushi Ochiai, Satoshi Kakuda, Yoshikazu Kuwahara, Yoshihiro Takai and Manabu Fukumoto
    • Organizer
      The joint symposium of the 7th international symposium network of the institute network and the 45th IDAC symposium, the 2nd symposium for joint usage/research center of aging
    • Place of Presentation
      Sendai
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Presentation] AKT阻害剤とCdk4阻害剤によるヒトがん細胞の放射線耐性の抑制2010

    • Author(s)
      志村勉
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-21
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Presentation] DNA-PK/ATK/GSK3β/Cyclin D1経路を標的としたヒトがん細胞の獲得放射線耐性の克服2010

    • Author(s)
      志村勉、桑原義和、高井良尋、福本学
    • Organizer
      日本癌学会
    • Place of Presentation
      都
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Presentation] DNA-PK/ATK/GSK3beta/Cyclin D1経路を標的としたヒトがん細胞の獲得放射線耐性の克服2010

    • Author(s)
      志村勉
    • Organizer
      日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Presentation] AKT阻害剤とCdk4阻害剤によるヒトがん細胞の放射線耐性の抑制2010

    • Author(s)
      志村勉、角田智、落合泰史、桑原義和、高井良尋、福本学
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      京
    • Year and Date
      2010-10-21
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Presentation] 長期分割放射線被ばくによるがん細胞の放射線耐性の獲得2009

    • Author(s)
      志村勉
    • Organizer
      第52回日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-11
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Presentation] 長期分割放射線被ばくによるがん細胞の放射線耐性の獲得2009

    • Author(s)
      志村勉、落合泰史、桑原義和、福本学
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-11
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Presentation] DNA-PK/AKT/GSK3b/cyclinD1経路を標的としたヒトがん細胞における放射線耐性の克服2009

    • Author(s)
      志村勉、角田智、高井良尋、桑原義和、福本学
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-11
    • Data Source
      KAKENHI-PROJECT-21710054
  • [Presentation] X線長期被ばくの生物影響 : サイクリンD1の過剰発現によるG1/Sチェックポイント機構の損失2008

    • Author(s)
      志村勉
    • Organizer
      放射線影響学会
    • Place of Presentation
      福岡県北九州国際会議場
    • Year and Date
      2008-11-19
    • Data Source
      KAKENHI-PROJECT-20810003
  • [Presentation] Perturbation of AKT/cyclin D1 signaling pathway by oxidative stresses following low dose long-term fractionated radiation in normal human fibroblasts.

    • Author(s)
      Tsutomu Shimura, Megumi Sasatani, Kenji Kamiya, Hidehiko Kawai, Naoki Kunugita.
    • Organizer
      The 5th International Symposium Biological Effects of Low Dose Radiation
    • Place of Presentation
      Hiroshima
    • Year and Date
      2015-03-02 – 2015-03-03
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Presentation] AKT経路を標的としたがん細胞の放射線耐性の抑制

    • Author(s)
      志村 勉
    • Organizer
      第43回放射線による制癌シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2014-07-11 – 2014-07-12
    • Invited
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Presentation] AKT経路を標的としたがん細胞の放射線耐性の抑制

    • Author(s)
      志村 勉、桑原 義和、福本 学
    • Organizer
      第57回日本放射線影響学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-01 – 2014-10-03
    • Data Source
      KAKENHI-PROJECT-24510063
  • [Presentation] 放射線高感受性細胞を用いた低線量放射線応答の解析

    • Author(s)
      志村 勉、小林 純也、小松 賢志、欅田 尚樹
    • Organizer
      第57回日本放射線影響学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-01 – 2014-10-03
    • Data Source
      KAKENHI-PROJECT-24510063
  • 1.  FUKUMOTO MANABU (60156809)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 2.  KUWAHARA Yoshikazu (00392225)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  USHIYAMA Akira (60291118)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  服部 研之 (90306663)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  笹谷 めぐみ (80423052)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  稲葉 洋平 (80446583)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  TATSUMI Naoya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  TOYOSHIMA Megumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 9.  SAKAI Wataru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  MATSUMOTO Syota
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  TANINO Mishie
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  IIZUKA Daisuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  小松 賢志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 14.  小林 純也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 15.  河合 秀彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 16.  尾路 祐介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  神谷 研二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 18.  阿部 靖之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  増田 雄司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  花岡 文雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  森 俊雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  青田 聖恵
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  井倉 毅
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  岩井 成憲
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  菅澤 薫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  斉藤 寿仁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  西塚 哲
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  久米 浩平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  竹本 和広
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  田中 伸哉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  渡利 英道
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  立石 智
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  野田 朝男
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  濱崎 幹也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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