Shimura Tsutomu 志村勉

… Alternative Names

Researcher Number	40463799
Other IDs
Affiliation (Current)	2022: 国立保健医療科学院, その他部局等, 上席主任研究官
Affiliation (based on the past Project Information) *help	2016 – 2020: 国立保健医療科学院, その他部局等, 上席主任研究官 2015 – 2017: 国立保健医療科学院, 生活環境研究部, 上席主任研究官 2013 – 2015: 国立保健医療科学院, その他部局等, その他 2012 – 2013: 国立保健医療科学院, 生活環境研究部, 上席主任研究官 2008 – 2010: Tohoku University, 加齢医学研究所, 助教 2009: 東北大, 加齢医学研究所, 助教
Review Section/Research Field	Principal Investigator Risk sciences of radiation/Chemicals / Environmental impact assessment / Health science and related fields / Basic Section 63020:Radiation influence-related Except Principal Investigator Experimental pathology / Risk sciences of radiation and chemicals / Medium-sized Section 63:Environmental analyses and evaluation and related fields
Keywords	Principal Investigator 放射線 / がん / ミトコンドリア / 活性酸素 / 酸化ストレス / 低線量放射線 / 放射線発がん / がんの微小環境 / 微小環境 / 放射線耐性 … More Except Principal Investigator 臨床的放射線耐性 / がん細胞 / ミトコンドリア / ワールブルグ効果 / 活性酸素種(ROS) / X線 / ドセタキセル / カタラーゼ / 電子伝達系 / 活性酸素 / 生物影響 / 低レベル放射線 / 微小循環 / 生体顕微鏡 / 酸化ストレス / 循環器系 / 放射線 / 発がん / 幹細胞 / 細胞競合 Less

発がんにおける組織幹細胞の細胞競合を可視化する解析系の確立とその応用
- Principal Investigator
  
  笹谷めぐみ (豊島めぐみ)
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Hiroshima University
Study of biological effects of ionizing radiation on mitochondriaPrincipal Investigator
- Principal Investigator
  
  志村勉
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  National Institute of Public Health
Role of the tumor microenvironment on radiation-induced carcinogenesisPrincipal Investigator
- Principal Investigator
  
  Shimura Tsutomu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Health science and related fields
- Research Institution
  National Institute of Public Health
The study on the low dose radiation on oxidative stress and cardiovascular systems on maice
- Principal Investigator
  
  USHIYAMA Akira
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  National Institute of Public Health
Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in low-dose irradiated human fibroblastsPrincipal Investigator
- Principal Investigator
  
  Shimura Tsutomu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental impact assessment
- Research Institution
  National Institute of Public Health
Eradication of radioresistant cancer stem cells by inhibiting the AKT survival signaling pathway.Principal Investigator
- Principal Investigator
  
  SHIMURA Tsutomu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  National Institute of Public Health
New developments in mitochondrial study to overcome
- Principal Investigator
  
  FUKUMOTO MANABU
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tohoku University
Analysis of the molecular mechanisms of acquired radioresistance induced by fractionated radiationPrincipal Investigator
- Principal Investigator
  
  SHIMURA Tsutomu
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
G1サイクリンを標的とした長期放射線被ばくマーカーの同定と有効な放射線療法の確立Principal Investigator
- Principal Investigator
  
  志村勉
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] Encyclopedia of Environmental Health, 2nd Edition.2019
- Author(s)
  Shimura T, Yamaguchi I. Kunugita N
- Total Pages
  4884
- Publisher
  ELSEVIER
- ISBN
  9780444639516
- Data Source
  KAKENHI-PROJECT-18H03377
[Book] Encyclopedia of Environmental Health, 2nd Edition.2019
- Author(s)
  Shimura T, Yamaguchi I. Kunugita N.
- Total Pages
  4884
- Publisher
  ELSEVIER
- ISBN
  9780444639516
- Data Source
  KAKENHI-PROJECT-17K19944
[Journal Article] Mechanism of turnover or persistence of radiation-induced myofibroblast in vitro2020
- Author(s)
  Shimura T, Ando T, Narao M, Sasatani M, Kamiya K, Ushiyama A
- Journal Title
  
  Cell Cycle
  
  Volume: 22 Pages: 1-11
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21846
[Journal Article] Fukushima Nuclear Disaster: Emergency Response to the Disaster2019
- Author(s)
  Shimura Tsutomu、Yamaguchi Ichiro、Kunugita Naoki
- Journal Title
  
  Encyclopedia of Environmental Health, 2nd Edition．
  
  Volume: -
- DOI
  10.1016/b978-0-12-409548-9.10974-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03377
[Journal Article] Epicatechin as a promising agent to countermeasure radiation exposure by mitigating mitochondrial damage in human fibroblasts and mouse hematopoietic cells.2019
- Author(s)
  Shimura T, Koyama M, Aono D, Kunugita N.
- Journal Title
  
  The FASEB J
  
  Volume: 33 Pages: 6867-6876
- DOI
  10.1096/fj.201802246rr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03377, KAKENHI-PROJECT-17K19944
[Journal Article] Lessons learned from radiation biology: Health effects of low levels of exposure to ionizing radiation on humans regarding the Fukushima accident.2018
- Author(s)
  Shimura Tsutomu, Yamaguchi Ichiro, Terada Hiroshi, Kunugita Naoki.
- Journal Title
  
  Journal of the National Institute of Public Health
  
  Volume: 67 Pages: 115-122
- NAID
  130006706963
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19944
[Journal Article] Lessons learned from radiation risk communication activities regarding the Fukushima nuclear accident.2018
- Author(s)
  Yamaguchi Ichiro, Shimura Tsutomu, Terada Hiroshi, Svendsen Erik.R., Kunugita Naoki
- Journal Title
  
  Journal of the National Institute of Public Health
  
  Volume: 67 Pages: 93-102
- NAID
  130006706928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19944
[Journal Article] Use of DNA-generated gold nanoparticles to radiosensitize and eradicate radioresistant glioma stem cells2018
- Author(s)
  Kunoh T, Shimura T, Kasai T, Matsumoto S, Mahmud H, Khayrani A, Seno M, Kunoh H, Takada J.
- Journal Title
  
  Nanotechnology
  
  Volume: 30
- DOI
  10.1088/1361-6528/aaedd5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19944, KAKENHI-PROJECT-18H03377
[Journal Article] Regulation values and current situation of radioactive materials in food.2018
- Author(s)
  Terada Hiroshi, Yamaguchi Ichiro, Shimura Tsutomu, Svendsen Erik.R., Kunugita Naoki.
- Journal Title
  
  Journal of the National Institute of Public Health
  
  Volume: 67 Pages: 21-33
- NAID
  130006706913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19944
[Journal Article] Tokyo Electric Power Company Fukushima Dai-ichi Nuclear Power Plant accident and public health.2018
- Author(s)
  Kunugita Naoki, Shimura Tsutomu, Terada Hiroshi, Yamaguchi Ichiro.
- Journal Title
  
  Journal of the National Institute of Public Health
  
  Volume: 67 Pages: 2-10
- NAID
  130006706916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19944
[Journal Article] Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS-Activated TGFbeta Signaling2018
- Author(s)
  Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 16(11) Pages: 1676-1686
- DOI
  10.1158/1541-7786.mcr-18-0321
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00553, KAKENHI-PROJECT-17K19944, KAKENHI-PUBLICLY-18H04978, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-18H03377, KAKENHI-PROJECT-16K00547, KAKENHI-PROJECT-20K20310
[Journal Article] Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level2017
- Author(s)
  Sasatani M, Xi Y, Kajimura J, Kawamura T, Piao J, Masuda Y, Honda H, Kubo K, Mikamoto T, Watanabe H, Xu Y, Kawai H, Shimura T, Noda A, Hamasaki K, Kusunoki Y, Zaharieva EK, Kamiya K.
- Journal Title
  
  Carcinogenesis
  
  Volume: 38(5) Pages: 570-578
- DOI
  10.1093/carcin/bgw208
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00547, KAKENHI-PROJECT-17K00553, KAKENHI-PROJECT-17K19944, KAKENHI-PROJECT-15H02818, KAKENHI-PROJECT-16K12594
[Journal Article] Targeting the AKT/cyclin D1 pathway to overcome intrinsic and acquired radioresistance of tumors for effective radiotherapy2017
- Author(s)
  Shimura T
- Journal Title
  
  International Journal of Radiation Biology
  
  Volume: 93 Pages: 381-385
- DOI
  10.1080/09553002.2016.1257832
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-17K19944
[Journal Article] Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level.2017
- Author(s)
  Kamiya K, Sasatani M, Xi Y, Kajimura J, Kawamura T, Piao J, Masuda Y, Honda H, Kubo K, Mikamoto T, Watanabe H, Xu Y, Kawai H, Shimura T, Noda A, Hamasaki K, Kusunoki Y, Zaharieva E.
- Journal Title
  
  Carcinogenesis
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K12220
[Journal Article] ミトコンドリアの放射線応答と放射線発がんへの影響2017
- Author(s)
  志村勉、欅田尚樹
- Journal Title
  
  放射線生物研究
  
  Volume: 52 Pages: 183-193
- NAID
  40021257662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19944
[Journal Article] A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells.2017
- Author(s)
  Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N.
- Journal Title
  
  Cell Cycle
  
  Volume: 16 Pages: 565-573
- DOI
  10.1080/15384101.2017.1284716
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26241013, KAKENHI-PROJECT-15H02819, KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-16K00547
[Journal Article] ATM-mediated mitochondrial damage response triggered by nuclear DNA damage in normal human lung fibroblasts2017
- Author(s)
  Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N.
- Journal Title
  
  Cell Cycle
  
  Volume: 16(24) Pages: 2345-2354
- DOI
  10.1080/15384101.2017.1387697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00547, KAKENHI-PROJECT-17K00553, KAKENHI-PROJECT-17K19944, KAKENHI-PROJECT-26241013, KAKENHI-PROJECT-15H02819, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-20K20310
[Journal Article] Severe mitochondrial damage associated with low-dose radiation sensitivity in ATM- and NBS1-deficient cells.2016
- Author(s)
  Shimura T, Kobayashi J, Komatsu K, Kunugita N.
- Journal Title
  
  Cell Cycle
  
  Volume: 15 Pages: 1099-1107
- DOI
  10.1080/15384101.2016.1156276
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-26241013, KAKENHI-PROJECT-15H02819
[Journal Article] Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts.2016
- Author(s)
  Shimura T, Sasatani M, Kamiya K, Kawai H, Inaba Y, Kunugita N.
- Journal Title
  
  Oncotarget
  
  Volume: 7 Pages: 3559-3570
- DOI
  10.18632/oncotarget.6518
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-25340033, KAKENHI-PROJECT-25340032, KAKENHI-PROJECT-25281020
[Journal Article] Mitochondrial reactive oxygen species-mediated genomic instability in low-dose irradiated human cells through nuclear retention of cyclin D12016
- Author(s)
  Shimura T and Kunugita N
- Journal Title
  
  Cell Cycle
  
  Volume: 15 Pages: 1410-1414
- DOI
  10.1080/15384101.2016.1170271
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12220
[Journal Article] SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair.2016
- Author(s)
  Akita M
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Pages: 10984-10984
- DOI
  10.1038/srep10984
- NAID
  120005820899
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K12203, KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-15K14953, KAKENHI-PROJECT-26550042, KAKENHI-ORGANIZER-22131001, KAKENHI-PLANNED-23116008, KAKENHI-PUBLICLY-26116517, KAKENHI-PROJECT-26870356, KAKENHI-PROJECT-26281020, KAKENHI-PROJECT-15H04646
[Journal Article] Systematic protein level regulation via degradation machinery induced by genotoxic drugs.2016
- Author(s)
  Kume K, Ishida K, Ikeda M, Takemoto K, Shimura T, Young L, Nishizuka SS.
- Journal Title
  
  Journal of Proteome Research
  
  Volume: 15 Pages: 205-15
- DOI
  10.1021/acs.jproteome.5b00759
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10114, KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-25462034, KAKENHI-PROJECT-25700030
[Journal Article] Efficiency of Excess Monitoring for Beef after the Fukushima Accident2015
- Author(s)
  Shimura T, Yamaguchi I, Terada H, Yunokawa T, Svendsen E.R., Kunugita N.
- Journal Title
  
  Food Safety
  
  Volume: 3 Issue: 3 Pages: 84-91
- DOI
  10.14252/foodsafetyfscj.2015018
- NAID
  130005102519
- ISSN
  2187-8404
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K12220
[Journal Article] Radiation Occupational Health Interventions Offered to Radiation Workers in Response to the Complex Catastrophic Disaster at the Fukushima Daiichi Nuclear Power Plant.2015
- Author(s)
  Shimura T, Yamaguchi I, Terada H, Okuda K, Svendsen E.R., Kunugita N.
- Journal Title
  
  J Radiat Res
  
  Volume: 56 Pages: 413-421
- DOI
  10.1093/jrr/rru110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24510063
[Journal Article] DNA damage signaling guards against perturbation of cyclin D1 expression triggered by low-dose long-term fractionated radiation.2015
- Author(s)
  Shimura T, Kobayashi J, Komatsu K, Kunugita N.
- Journal Title
  
  Oncogenesis
  
  Volume: 3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24510063
[Journal Article] RAD18 activates the G2/M checkpoint through DNA damage signaling to maintain genome integrity after ionizing radiation exposure.2015
- Author(s)
  Sasatani M, Xu Y, Kawai H, Cao L, Tateishi S, Shimura T, Li J, Iizuka D, Noda A, Hamasaki K, Kusunoki Y, Kamiya K.
- Journal Title
  
  Plos One
  
  Volume: 10 Pages: 1-16
- DOI
  10.1371/journal.pone.0117845
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24510063, KAKENHI-PUBLICLY-25131715, KAKENHI-PROJECT-25340032, KAKENHI-PROJECT-25550031, KAKENHI-PROJECT-26340024, KAKENHI-PROJECT-25220102, KAKENHI-PROJECT-25281020
[Journal Article] Wilms' tumor gene WT1 promotes homologous recombination- mediated DNA damage repair.2015
- Author(s)
  Oji Y, Kobayashi J, et al.
- Journal Title
  
  Mol Carcinog.
  
  Volume: in press Pages: 1758-1771
- DOI
  10.1002/mc.22248
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24310041, KAKENHI-PROJECT-24510063, KAKENHI-PROJECT-24591395, KAKENHI-PUBLICLY-25112513, KAKENHI-PROJECT-25460685, KAKENHI-PROJECT-26241013, KAKENHI-PROJECT-26550025, KAKENHI-PROJECT-15K09476
[Journal Article] Public Health Activities for Mitigation of Radiation Exposures and Risk Communication Challenges after the Fukushima Nuclear Accident Journal of Radiation Research2015
- Author(s)
  Shimura T, Yamaguchi I, Terada H, Kengo O, Svendsen E.R., Kunugita N.
- Journal Title
  
  J Radiat Res
  
  Volume: 56 Pages: 422-429
- DOI
  10.1093/jrr/rrv013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24510063
[Journal Article] The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage.2015
- Author(s)
  Fu H, Martin M, Regairaz M, Huang L, You Y, Lin C, Ryan M, Kim R, Shimura T, Pommier Y, Aladjem M.
- Journal Title
  
  Nature Communications
  
  Volume: 6
- DOI
  10.1038/ncomms7746
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K12220
[Journal Article] Nuclear accumulation of cyclin D1 following long-term fractionated exposures to low-dose ionizing2014
- Author(s)
  Shimura T, Hamada N, Sasatani M, Kamiya K, Kunugita N
- Journal Title
  
  Cell cycle
  
  Volume: 13 Pages: 1248-1255
- DOI
  10.4161/cc.28139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510063, KAKENHI-PROJECT-25281020, KAKENHI-PROJECT-25340032, KAKENHI-PROJECT-25550031
[Journal Article] AKT-mediated enhanced aerobic glycolysis causes acquired radioresistance by human tumor cells.2014
- Author(s)
  Shimura T, Noma N, Sano Y, Ochiai Y, Oikawa T, Fukumoto M, Kunugita N.
- Journal Title
  
  Radiotherapy and Oncology
  
  Volume: 112 Pages: 302-307
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24510063
[Journal Article] 長期放射線被爆とサイクリンD12014
- Author(s)
  志村勉、欅田尚樹
- Journal Title
  
  生体の科学
  
  Volume: 65 Pages: 176-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510063
[Journal Article] Nuclear accumulation of cyclin D1 following long-term fractionated exposures to low-dose ionizing radiation in normal human diploid cells.2014
- Author(s)
  Shimura T, Hamada N, Sasatani M, Kamiya K, Kunugita N.
- Journal Title
  
  Cell Cycle
  
  Volume: 13 Pages: 1248-55
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24510063
[Journal Article] Distribution of Artificial Radionuclides in the Abandoned Cattle in the Evacuation Zone of the Fukushima Daiichi Nuclear Power Plant2013
- Author(s)
  Fukuda T, Kino Y, Abe Y, Yamashiro H, Kuwahara Y, Nihei H, Sano Y, Irisawa A, Shimura T, Fukumoto M, Shinoda H, Obata Y, Saigusa S, Sekine T, Isogai E, Fukumoto M.
- Journal Title
  
  PLoS One.
  
  Volume: 8(1) Pages: 1-7
- DOI
  10.1371/journal.pone.0054312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710066, KAKENHI-PROJECT-23780278, KAKENHI-PROJECT-24510063, KAKENHI-PROJECT-24659174, KAKENHI-PROJECT-25340026
[Journal Article] 長期放射線被ばくによるサイクリンD1 発現制御の破綻2013
- Author(s)
  志村勉、野間直十、佐野由衣、落合泰史、及川利幸、角田智、福本学、欅田尚樹
- Journal Title
  
  放射線生物研究
  
  Volume: 48 Pages: 323-335
- NAID
  40019928917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510063
[Journal Article] Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells.2013
- Author(s)
  Shimura T, Ochiai Y, Noma N, Oikawa T, Sano Y, Fukumoto M.
- Journal Title
  
  Cell Cycle
  
  Volume: 12 Pages: 773-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510063
[Journal Article] Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells2013
- Author(s)
  Shimura T , Ochiai Y, Noma N, Oikawa T, Sano Y, Fukumoto M.
- Journal Title
  
  Cell Cycle
  
  Volume: 1;12(5) Pages: 773-82
- DOI
  10.4161/cc.23719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659174
[Journal Article] 放射線生物学から見た低線量放射線の生体影響2013
- Author(s)
  志村勉
- Journal Title
  
  保健医療科学
  
  Volume: 62 Pages: 189-195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510063
[Journal Article] The role of cyclin D1 in response to long-term exposure to ionizing radiation2013
- Author(s)
  Shimura T, Fukumoto M, Kunugita N
- Journal Title
  
  Cell Cycle
  
  Volume: 12 Pages: 2738-2743
- DOI
  10.4161/cc.25746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510063, KAKENHI-PROJECT-24659174
[Journal Article] Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells.2012
- Author(s)
  Shimura T, Noma N, Oikawa T, Ochiai Y, Kakuda S, Kuwahara Y, Takai Y, Takahashi A, Fukumoto M.
- Journal Title
  
  Oncogenesis
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510063
[Journal Article] Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells2012
- Author(s)
  Shimura T, Noma N, Oikawa T, Ochiai Y, Kakuda S, Kuwahara Y, Takai Y, Fukumoto M.
- Journal Title
  
  Oncogenesis
  
  Volume: 1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659174
[Journal Article] Interactions of MCP1 with Components of the Replication Machinery in Mammalian Cells2011
- Author(s)
  Bronze-da-Rocha E, Lin CM, Shimura T, Aladjem MI.
- Journal Title
  
  Int J Biol Sci
  
  Volume: 7 Pages: 193-208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710054
[Journal Article] Targeting the AKT/GSK3beta/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radio therapy2011
- Author(s)
  Shimura T, et al.
- Journal Title
  
  International Journal of Radiation Oncology Biology Physics
  
  Volume: (未定印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710054
[Journal Article] Interactions of MCP1 with Components of the Replication Machinery in Mammalian Cells.2011
- Author(s)
  Bronze-da-Rocha E, Lin CM, Shimura T, Aladjem MI.
- Journal Title
  
  Int J Biol Sci 7
  
  Pages: 193-208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710054
[Journal Article] Targeting the AKT/GSK3b/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy2011
- Author(s)
  Shimura T, Kakuda S, Ochiai Y, Kuwahara Y, Takai Y, Fukumoto M.
- Journal Title
  
  International Journal of Radiation Oncology Biology Physics 80
  
  Pages: 540-548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710054
[Journal Article] Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpression.2010
- Author(s)
  Shimura T, Kakuda S, Ochiai Y, Nakagawa H, Kuwahara Y, Takai Y, Kobayashi J, Komatsu K, Fukumoto M.
- Journal Title
  
  Oncogene 29
  
  Pages: 4826-4837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710054
[Journal Article] Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpression.2010
- Author(s)
  Shimura T, et al.
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 4826-4837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710054
[Journal Article] The modified high-density survival assay is the useful tool to predict the effectiveness of fractionated radiation exposure.2010
- Author(s)
  Kuwahara Y, Mori M, Oikawa T, Shimura T, Ohtake Y, Mori S, Ohkubo Y, Fukumoto M.
- Journal Title
  
  J Radiat Res (Tokyo) 51
  
  Pages: 297-302
- NAID
  10026471144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710054
[Journal Article] X-radiation-induced down-regulation of the EGF receptor in primary cultured rat hepatocytes.2010
- Author(s)
  Maruko A, Ohtake Y, Kawaguchi M, Kobayashi T, Baba T, Kuwahara Y, Nakagawa H, Shimura T, Fukumoto M, Ohkubo Y.
- Journal Title
  
  Radiat Res 173
  
  Pages: 620-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710054
[Journal Article] Clinically relevant radioresistant cells efficiently repair DNA double-strand breaks induced by X-rays.2009
- Author(s)
  Kuwahara Y, Li L, Baba T, Nakagawa H, Shimura T, Yamamoto Y, Ohkubo Y, Fukumoto M.
- Journal Title
  
  Cancer Sci 100
  
  Pages: 747-752
- NAID
  10025144817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710054
[Journal Article] Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress2008
- Author(s)
  Tsutomu Shimura
- Journal Title
  
  Journal of Molecular Biology 375
  
  Pages: 1152-1164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20810003
[Presentation] Epicatechin as a promising agent to countermeasure radiation exposure by mitigating mitochondrial damage in human fibroblasts and mouse hematopoietic cells.2019
- Author(s)
  Shimura T , Koyama M, Aono D, Kunugita N.
- Organizer
  日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-17K19944
[Presentation] Epicatechin as a promising agent to countermeasure radiation exposure by mitigating mitochondrial damage in human fibroblasts and mouse hematopoietic cells.2019
- Author(s)
  Shimura T , Koyama M, Aono D, Kunugita N
- Organizer
  日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-18H03377
[Presentation] Radiation-induced mitochondrial damage in neural progenitor stem cells and differentiated cells.2018
- Author(s)
  Shimura Tsutomu and Kunugita Naoki
- Organizer
  The 8th Annual Meeting of the International Society of Radiation Neurobiology.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19944
[Presentation] 放射線誘発がん関連線維芽細胞は、活性酸素によるTGFbeta;シグナリング経路の活性化を介してがんの増殖を促進する2018
- Author(s)
  志村勉、笹谷めぐみ、河合秀彦、神谷研二、小林純也、小松賢志、欅田尚樹
- Organizer
  第61回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-18H03377
[Presentation] 放射線誘発がん関連線維芽細胞は、活性酸素によるTGFbeta;シグナリング経路の活性化を介してがんの増殖を促進する2018
- Author(s)
  志村勉、笹谷めぐみ、河合秀彦、神谷研二、小林純也、小松賢志、欅田尚樹
- Organizer
  第61回日本放射線影響学会,
- Data Source
  KAKENHI-PROJECT-17K19944
[Presentation] A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells.2017
- Author(s)
  Shimura T, Sasatani M, Kawai H, Kamiya K and Kunugita N.
- Organizer
  The 1st international symposium of the network-type joint usage/research center for radiation disaster medical science
- Place of Presentation
  広島
- Year and Date
  2017-02-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12220
[Presentation] A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells.2017
- Author(s)
  Shimura Tsutomu, Sasatani Megumi, Kawai Hidehiko, Kamiya Kenji, Kunugita Naoki.
- Organizer
  The 1st international symposium of the network-type joint usage/research center for radiation disaster medical science.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19944
[Presentation] ATMが制御する核とミトコンドリアの放射線応答2017
- Author(s)
  志村勉、笹谷めぐみ、河合秀彦、神谷研二、小林純也、小松賢志、欅田尚樹
- Organizer
  第60回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-17K19944
[Presentation] 低線量長期放射線照射におけるミトコンドリア由来活性酸素の蓄積と酸化ストレスによる細胞周期制御機構への影響2016
- Author(s)
  志村勉、笹谷めぐみ、河合秀彦、神谷研二、欅田尚樹.
- Organizer
  第59回日本放射線影響学会
- Place of Presentation
  広島
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15K12220
[Presentation] Mitochondrial DNA damage responses in ATM- and NBS1-deficient cells.2016
- Author(s)
  Shimura T, Kobayashi J, Komatsu K, Kunugita N.
- Organizer
  第59回日本放射線影響学会
- Place of Presentation
  広島
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15K12220
[Presentation] DNA damage signaling guards against perturbation of cyclin D1 expression by low-dose long-term fractionated radiation.2015
- Author(s)
  Tsutomu Shimura, Junya Kobayashi, Kenshi Komatsu, Naoki Kunugita.
- Organizer
  15th International congress of radiation research
- Place of Presentation
  京都
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12220
[Presentation] Cyclin D1 as a molecular marker and possible molecular radioprotection target for long-term exposure to low-dose ionizing radiation2014
- Author(s)
  Tsutomu Shimura, Megumi Sasatani, Kenji Kamiya, Nobuyuki Hamada, Naoki Kunugita
- Organizer
  The 4th International Symposium Hiroshima-Nagasaki collaborative research on radiation disaster medicine
- Place of Presentation
  hirosima
- Data Source
  KAKENHI-PROJECT-24510063
[Presentation] 低線量長期放射線によるサイクリンD1発現制御の破綻2013
- Author(s)
  志村　勉、笹谷めぐみ、神谷研二、浜田信行、欅田尚樹
- Organizer
  第56回日本放射線影響学会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-24510063
[Presentation] Eradication of radioresistant tumors by inhibiting the AKT survival signaling pathway2013
- Author(s)
  Tsutomu Shimura, Naoto Noma, Toshiyuki Oikawa, Yasushi Ochiai, Yui Sano, Satoshi Kakuda, Manabu Fukumoto
- Organizer
  3rd International symposium Biological effects of low dose radiation
- Place of Presentation
  Hiroshima
- Data Source
  KAKENHI-PROJECT-24510063
[Presentation] Eradication of radioresistant tumors by inhibiting the AKT survival signaling pathway.2012
- Author(s)
  Tsutomu Shimura, Naoto Noma, Toshiyuki Oikawa, Yasushi Ochiai, Satoshi Kakuda, Yoshikazu Kuwahara, Yoshihiro Takai and Manabu Fukumoto
- Organizer
  The joint symposium of the 7th international symposium network of the institute network and the 45th IDAC symposium, the 2nd symposium for joint usage/research center of aging
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-24510063
[Presentation] 低線量放射線に対するサイクリンD1の応答の解析2012
- Author(s)
  志村勉、桑原　義和、福本　学、寺田　宙、欅田尚樹
- Organizer
  第55回日本放射線影響学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24510063
[Presentation] DNA-PK/ATK/GSK3β/Cyclin D1経路を標的としたヒトがん細胞の獲得放射線耐性の克服2010
- Author(s)
  志村勉、桑原義和、高井良尋、福本学
- Organizer
  日本癌学会
- Place of Presentation
  都
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21710054
[Presentation] AKT阻害剤とCdk4阻害剤によるヒトがん細胞の放射線耐性の抑制2010
- Author(s)
  志村勉
- Organizer
  日本放射線影響学会
- Place of Presentation
  京都
- Year and Date
  2010-10-21
- Data Source
  KAKENHI-PROJECT-21710054
[Presentation] DNA-PK/ATK/GSK3beta/Cyclin D1経路を標的としたヒトがん細胞の獲得放射線耐性の克服2010
- Author(s)
  志村勉
- Organizer
  日本癌学会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21710054
[Presentation] AKT阻害剤とCdk4阻害剤によるヒトがん細胞の放射線耐性の抑制2010
- Author(s)
  志村勉、角田智、落合泰史、桑原義和、高井良尋、福本学
- Organizer
  日本放射線影響学会
- Place of Presentation
  京
- Year and Date
  2010-10-21
- Data Source
  KAKENHI-PROJECT-21710054
[Presentation] 長期分割放射線被ばくによるがん細胞の放射線耐性の獲得2009
- Author(s)
  志村勉
- Organizer
  第52回日本放射線影響学会
- Place of Presentation
  広島
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-21710054
[Presentation] DNA-PK/AKT/GSK3b/cyclinD1経路を標的としたヒトがん細胞における放射線耐性の克服2009
- Author(s)
  志村勉、角田智、高井良尋、桑原義和、福本学
- Organizer
  日本放射線影響学会
- Place of Presentation
  広島
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-21710054
[Presentation] DNA-PK/AKT/GSK3b/cyclin D1経路を標的としたヒトがん細胞における放射線耐性の克服2009
- Author(s)
  志村勉
- Organizer
  第52回日本放射線影響学会
- Place of Presentation
  広島
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-21710054
[Presentation] 長期分割放射線被ばくによるがん細胞の放射線耐性の獲得2009
- Author(s)
  志村勉、落合泰史、桑原義和、福本学
- Organizer
  日本放射線影響学会
- Place of Presentation
  広島
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-21710054
[Presentation] 複製フォーク進行阻害により誘導されるDNA2重鎖切断の生成機構とその修復2008
- Author(s)
  志村勉
- Organizer
  放射線影響学会
- Place of Presentation
  福岡県北九州国際会議場
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-20810003
[Presentation] X線長期被ばくの生物影響 : サイクリンD1の過剰発現によるG1/Sチェックポイント機構の損失2008
- Author(s)
  志村勉
- Organizer
  放射線影響学会
- Place of Presentation
  福岡県北九州国際会議場
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-20810003
[Presentation] AKT経路を標的としたがん細胞の放射線耐性の抑制
- Author(s)
  志村　勉
- Organizer
  第４３回放射線による制癌シンポジウム
- Place of Presentation
  京都
- Year and Date
  2014-07-11 – 2014-07-12
- Invited
- Data Source
  KAKENHI-PROJECT-24510063
[Presentation] Perturbation of AKT/cyclin D1 signaling pathway by oxidative stresses following low dose long-term fractionated radiation in normal human fibroblasts.
- Author(s)
  Tsutomu Shimura, Megumi Sasatani, Kenji Kamiya, Hidehiko Kawai, Naoki Kunugita.
- Organizer
  The 5th International Symposium Biological Effects of Low Dose Radiation
- Place of Presentation
  Hiroshima
- Year and Date
  2015-03-02 – 2015-03-03
- Data Source
  KAKENHI-PROJECT-24510063
[Presentation] AKT経路を標的としたがん細胞の放射線耐性の抑制
- Author(s)
  志村　勉、桑原　義和、福本　学
- Organizer
  第57回日本放射線影響学会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-24510063
[Presentation] 放射線高感受性細胞を用いた低線量放射線応答の解析
- Author(s)
  志村　勉、小林　純也、小松　賢志、欅田　尚樹
- Organizer
  第57回日本放射線影響学会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-24510063

1. 笹谷めぐみ (80423052)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. FUKUMOTO MANABU (60156809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. KUWAHARA Yoshikazu (00392225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. USHIYAMA Akira (60291118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 服部研之 (90306663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 稲葉洋平 (80446583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 神谷研二 (60116564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. TOYOSHIMA Megumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
9. IIZUKA Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. TATSUMI Naoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. SAKAI Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. MATSUMOTO Syota

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 阿部靖之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 河合秀彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
15. 増田雄司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 小松賢志

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
17. 小林純也

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
18. 立石智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 野田朝男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 濱崎幹也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 尾路祐介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 花岡文雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 森俊雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 青田聖恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 井倉毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 岩井成憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 菅澤薫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 斉藤寿仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 西塚哲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 久米浩平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 竹本和広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimura Tsutomu 志村 勉

SHIMURA Tsutomu 志村 勉

Research Projects

Research Products

Co-Researchers

発がんにおける組織幹細胞の細胞競合を可視化する解析系の確立とその応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of biological effects of ionizing radiation on mitochondriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of the tumor microenvironment on radiation-induced carcinogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study on the low dose radiation on oxidative stress and cardiovascular systems on maice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in low-dose irradiated human fibroblastsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Eradication of radioresistant cancer stem cells by inhibiting the AKT survival signaling pathway.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New developments in mitochondrial study to overcome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the molecular mechanisms of acquired radioresistance induced by fractionated radiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

G1サイクリンを標的とした長期放射線被ばくマーカーの同定と有効な放射線療法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Encyclopedia of Environmental Health, 2nd Edition.2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Encyclopedia of Environmental Health, 2nd Edition.2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Mechanism of turnover or persistence of radiation-induced myofibroblast in vitro2020

Author(s)

Journal Title

Data Source

[Journal Article] Fukushima Nuclear Disaster: Emergency Response to the Disaster2019

Author(s)

Journal Title

DOI

Data Source

Shimura Tsutomu 志村勉

SHIMURA Tsutomu 志村勉