Li Peili 李佩俐

Researcher Number	40464292
Other IDs
Affiliation (based on the past Project Information) *help	2013 – 2022: 鳥取大学, 医学(系)研究科(研究院), 助教 2021: 鳥取大学, 医学部, 助教 2020 – 2021: 鳥取大学, 医学部, 特命助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Basic Section 53020:Cardiology-related / General physiology / Regenerative medicine
Keywords	Principal Investigator 心房細動 / inflammasome / monosodium urate / NLRP3 inflammsome / macrophage / gout / Kv1.5 channel / heat shock protein 70 / K efflux / 尿酸結晶 … More / Heat shock protein / atrial fibrillation / Monosodium urate / NLRP3 inflammasome / Kv1.5 / protein quality control / chaperone / histone deacetylase 10 / Histone deacetylase 6 / histine deacetylase / mutant hERG / mutation / histone deacetylase / HDAC阻害剤 / HDAC6 / ユビキチン化 / アセチル化 / 変異hERG / lysine / ubiquitination / acetylation / histone deacetylase 6 / hERG / LQT2 … More Except Principal Investigator MLC2v / HCN4 / 可視化 / iPS細胞 / ペースメーカ細胞 / 蛍光タンパク質 / イオンチャネル / マウス / 血管内皮細胞 / 線維芽細胞 / 心臓常在マクロファージ / 尿酸塩結晶 / 心房細動 / 常在マクロファージ / 心臓 / 高尿酸血症 / バイオテクノロジー / 生理学 / 再生医学 / MiRP1 / 心室筋細胞 / ゲノム編集 / 心筋 / ヒトiPS 細胞 / 洞結節ペースメーカ / MIRP1 / 先天性QT延長症候群 / 心室筋 / QT延長症候群 / 疾患iPS細胞 / HCN4イオンチャネル / 心筋細胞 / CRISPR/Cas9 / 心筋分化誘導 / ペースメーカ細部 / 再生医療 / 心筋分化 / ヒトiPS細胞 / ヒトES細胞 Less

A study of the novel molecular mechanism of atrial fibrillation induced by cardiac resident macrophages in hyperuricemia
- Principal Investigator
  
  TSUNETO Motokazu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tottori University
Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytesPrincipal Investigator
- Principal Investigator
  
  LI Peili
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tottori University
Elucidation of the pathophysiology and etiology of congenital long QT syndrome type 6 by myocardial cell screening and iPS technology
- Principal Investigator
  
  SHIRAYOSHI Yasuaki
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tottori University
Fluorescent reporter lines in human iPS cells offer useful platforms to study cardiac subtype specification, cell-based therapies of cardiac disease and drug development.
- Principal Investigator
  
  Shirayoshi Yasuaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Regenerative medicine
- Research Institution
  Tottori University
The role of Hsp70 in quality control of mutant hERG protein associated LQT2 and its therapeutic application.Principal Investigator
- Principal Investigator
  
  Li Peili
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Tottori University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Other

[Journal Article] α1-Adrenergic receptor mediates adipose-derived stem cell sheet-induced protection against chronic heart failure after myocardial infarction in rats2022
- Author(s)
  Horie H, Hisatome I, Kurata Y, Yamamoto Y, Notsu T, Adachi M, Li P, et al
- Journal Title
  
  Hypertension research
  
  Volume: 45 Issue: 2 Pages: 283-291
- DOI
  10.1038/s41440-021-00802-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08074, KAKENHI-PROJECT-19K08557, KAKENHI-PROJECT-21K08844
[Journal Article] Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes2022
- Author(s)
  Peili Li, Yasutaka Kurata, Fikri Taufiq, et al
- Journal Title
  
  Molecular Biology Reports
  
  Volume: online ahead of print Issue: 7 Pages: 0-0
- DOI
  10.1007/s11033-022-07378-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08074, KAKENHI-PROJECT-20K17168, KAKENHI-PROJECT-19K08557, KAKENHI-PROJECT-22K06979
[Journal Article] Early effects of an adipose-derived stem cell sheet against detrusor underactivity in a rat cryo-injury model2022
- Author(s)
  Shogo Teraoka, Masashi Honda, Karen Makishima, Ryutaro Shimizu , Panagiota Tsounapi, Tetsuya Yumioka, Hideto Iwamoto, Peili Li , et al
- Journal Title
  
  Life sciences
  
  Volume: online ahead of print Pages: 0-0
- DOI
  10.1016/j.lfs.2022.120604
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08074
[Journal Article] Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease　― Japanese Guideline on the Management of Asymptomatic Hyperuricemia ―2021
- Author(s)
  Hisatome Ichiro、Li Peili、Miake Junichiro、Taufiq Fikri、Mahati Endang、Maharani Nani、Utami Sulistiyati Bayu、Kuwabara Masanari、Bahrudin Udin、Ninomiya Haruaki
- Journal Title
  
  Circ J
  
  Volume: 85 Issue: 2 Pages: 130-138
- DOI
  10.1253/circj.CJ-20-0406
- NAID
  130007975319
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2021-01-25
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20662, KAKENHI-PROJECT-18K08074, KAKENHI-PROJECT-20K17168
[Journal Article] Novel inhibitory effects of dotinurad, a selective urate reabsorption inhibitor, on urate crystal-induced activation of NLRP3 inflammasomes in macrophages2020
- Author(s)
  Taufiq F, Li P, Kuwabara M, et al
- Journal Title
  
  Vascular Failure
  
  Volume: 3 Issue: 2 Pages: 59-67
- DOI
  10.30548/vascfail.3.2_59
- NAID
  130007835261
- ISSN
  2432-4477
- Year and Date
  2020-04-24
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08074
[Journal Article] Evidence for Urate Uptake Through Monocarboxylate Transporter 9 Expressed in Mammalian Cells and Its Enhancement by Heat Shock2020
- Author(s)
  Otani Naoyuki、Kurata Yasutaka、Maharani Nani、Kuwabara Masanari、Ikeda Nobuhito、Notsu Tomomi、Li Peili、Miake Junichiro、Yoshida Akio、Sakaguchi Hiromi、Higaki Katsumi、Nakasone Naoe、Tsuneto Motokazu、Shirayoshi Yasuaki、Ouchi Motoshi、Ninomiya Haruaki、Yamamoto Kazuhiro、Anzai Naohiko、Hisatome Ichiro
- Journal Title
  
  Circulation Reports
  
  Volume: 2 Issue: 8 Pages: 425-432
- DOI
  10.1253/circrep.cr-20-0016
- NAID
  130007885744
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08557, KAKENHI-PROJECT-20K20662, KAKENHI-PROJECT-18K08200, KAKENHI-PROJECT-18K08074
[Journal Article] Inhibitory effects of class I antiarrhythmic agents on Na+ and Ca2+ currents of human iPS cell-derived cardiomyocytes.2019
- Author(s)
  Yonemizu S, Masuda K, Kurata Y, Notsu T, Higashi Y, Fukumura K, Li P, Ninomiya H, Miake J, Tsuneto M, Shirayoshi Y, Hisatome I.
- Journal Title
  
  Regen Ther.
  
  Volume: 10 Pages: 104-111
- DOI
  10.1016/j.reth.2018.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08539, KAKENHI-PROJECT-17K09580, KAKENHI-PROJECT-18K08074
[Journal Article] Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes2019
- Author(s)
  Taufiq Fikri、Maharani Nani、Li Peili、Kurata Yasutaka、Ikeda Nobuhito、Kuwabara Masanari、Otani Naoyuki、Miake Junichiro、Hasegawa Akira、Tsuneto Motokazu、Shirayoshi Yasuaki、Ninomiya Haruaki、Saitoh Tatsuya、Nakai Akira、Yamamoto Kazuhiro、Hisatome Ichiro
- Journal Title
  
  Circ J
  
  Volume: 83 Issue: 4 Pages: 718-726
- DOI
  10.1253/circj.CJ-18-1088
- NAID
  130007620506
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2019-03-25
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0229, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06415, KAKENHI-PROJECT-18H02625, KAKENHI-PROJECT-18K08074
[Journal Article] Novel inhibitory effects of dotinurad, a selective urate reabsorption inhibitor, on urate crystal-induced activation of NLRP3 inflammasomes in macrophages2019
- Author(s)
  Fikri Taufiq, Peili Li, Masanari Kuwabara, Yasutaka Kurata, et al
- Journal Title
  
  Vascular Failure
  
  Volume: 3 Pages: 59-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08074
[Journal Article] Hyperuricemia as a Risk Factor for Atrial Fibrillation Due to Soluble and Crystalized Uric Acid2019
- Author(s)
  Fikri Taufiq, Peili Li*; Junichiro Miake, Ichiro Hisatome,
- Journal Title
  
  Circulation Reports
  
  Volume: 1 Issue: 11 Pages: 469-473
- DOI
  10.1253/circrep.CR-19-0088
- NAID
  130007742752
- ISSN
  2434-0790
- Year and Date
  2019-11-08
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08074
[Journal Article] Restoration of mutant hERG stability by inhibition of HDAC62018
- Author(s)
  Li Peili、Kurata Yasutaka、Endang Mahati、Ninomiya Haruaki、Higaki Katsumi、Taufiq Fikri、Morikawa Kumi、Shirayoshi Yasuaki、Horie Minoru、Hisatome Ichiro
- Journal Title
  
  J mol Cell cardiol
  
  Volume: 115 Pages: 158-169
- DOI
  10.1016/j.yjmcc.2018.01.009
- NAID
  120007170666
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08539, KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-15K08277, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-18K08074
[Journal Article] Isolation and characterization of ventricular-like cells derived from NKX2-5 eGFP/w and MLC2v mCherry/w double knock-in human pluripotent stem cells2018
- Author(s)
  Yamauchi Kaori、Li Junjun、Morikawa Kumi、Liu Li、Shirayoshi Yasuaki、Nakatsuji Norio、Elliott David A.、Hisatome Ichiro、Suemori Hirofumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 1 Pages: 1278-1284
- DOI
  10.1016/j.bbrc.2017.11.133
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08539, KAKENHI-PROJECT-17K09580
[Journal Article] Molecular mechanisms underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells2017
- Author(s)
  Onohara, Takeshi; Hisatome, Ichiro; Kurata, Yasutaka; Li, Peili; Notsu, Tomomi; Morikawa, Kumi; Otani, Naoyuki; Yoshida, Akio; Iitsuka, Kazuhiko; Kato, Masaru; Miake, Junichiro; Ninomiya, Haruaki; Higaki, Katsumi; Shirayoshi, Yasuaki; Nishihara, Takashi; Itoh, Toshiyuki; Nakamura, Yoshinobu; Nishimura, Motonobu
- Journal Title
  
  J. Arrhythmia,
  
  Volume: 32 Issue: 3 Pages: 226-233
- DOI
  10.1016/j.joa.2016.09.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26241030, KAKENHI-PROJECT-26501003, KAKENHI-PROJECT-15K21170, KAKENHI-PROJECT-17K08539, KAKENHI-PROJECT-15K08277
[Journal Article] Electrophysiological properties of iPS cell-derived cardiomyocytes from a patient with long QT syndrome type 1 harboring the novel mutation M437V of KCNQ12016
- Author(s)
  Sogo T, Morikawa K, Kurata Y, Li P, Ichinose T, Yuasa S, Nozaki D, Miake J, Ninomiya H, Shimizu W, Fukuda K, Yamamoto K, Shirayoshi Y, Hisatome I
- Journal Title
  
  Regenerative Therapy
  
  Volume: 4 Pages: 9-17
- DOI
  10.1016/j.reth.2015.12.001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460303, KAKENHI-PROJECT-25461109
[Journal Article] Electrophysiological Properties of iPS Cell-Derived Cardiomyocytes from a Patient with Long QT Syndrome Type 1 Harboring the Novel Mutation M437V of KCNQ12016
- Author(s)
  Tatsufumi Sogo; Kumi Morikawa; Yasutaka Kurata; Peili Li; Takafumi Ichinose; Shinsuke Yuasa; Daizou Nozaki; Junichiro Miake, Haruaki Ninomiya, Wataru Shimizu, Keiichi Fukuda, Kazuhiro Yamamoto, Yasuaki Shirayoshi and Ichiro Hisatome.
- Journal Title
  
  Regenerative Therapy
  
  Volume: 4 Pages: 9-17
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26501003
[Journal Article] M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells2016
- Author(s)
  Mahati E., Li P., Kurata Y., Maharani N., Nobuhito I., Sakata S., Ogura K., Miake J., Aiba T., Shimizu W., Nakasone N., Ninomiya H., Higaki K., Yamamoto K., Nakai A., Shirayoshi Y., Hisatome I.
- Journal Title
  
  Circ J
  
  Volume: 80 Issue: 12 Pages: 2443-2452
- DOI
  10.1253/circj.CJ-16-0712
- NAID
  130005284978
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04706, KAKENHI-PROJECT-26501003
[Journal Article] Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1.2016
- Author(s)
  Kondo T., Hisatome I., Yoshimura S., Mahati E., Notsu T., Li P., Iitsuka K., Kato M., Ogura K., Miake J., Aiba T., Shimizu W., Kurata Y., Sakata S., Nakasone N., Ninomiya H., Nakai A., Higaki K., Kawata Y., Shirayoshi Y., Yoshida A., Yamamoto K.
- Journal Title
  
  Journal of Arrhythmia
  
  Volume: 32 Issue: 5 Pages: 433-440
- DOI
  10.1016/j.joa.2015.10.005
- NAID
  120007146982
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04706, KAKENHI-PROJECT-26501003
[Journal Article] Molecular Mechanisms Underlying Urate-Induced Enhancement of Kv1.5 Channel Expression in HL-1 Atrial Myocytes2015
- Author(s)
  Maharani N, Ting YK, Cheng J, Hasegawa A, Kurata Y, Li P, Nakayama Y, Ninomiya H, Ikeda N, Morikawa K, Yamamoto K, Makita N, Yamashita T, Shirayoshi Y, Hisatome I.
- Journal Title
  
  Circ J
  
  Volume: 79 Issue: 12 Pages: 2659-2668
- DOI
  10.1253/circj.CJ-15-0416
- NAID
  130005110934
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26501003, KAKENHI-PROJECT-15K15311, KAKENHI-PROJECT-15K21170, KAKENHI-PROJECT-15H04823, KAKENHI-PROJECT-25461109, KAKENHI-PROJECT-24390199
[Journal Article] Stabilization of Kv1.5 channel protein by the inotropic agent olprinone.2015
- Author(s)
  Endo R, Kurata Y, Notsu T, Li P, Morikawa K, Kondo T, Ogura K, Miake J, Yoshida A, Shirayoshi Y, Ninomiya H, Higaki K, Kuwabara M, Yamamoto K, Inagaki Y, Hisatome I.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 765 Pages: 488-494
- DOI
  10.1016/j.ejphar.2015.09.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26501003, KAKENHI-PROJECT-15K21170, KAKENHI-PROJECT-25461109
[Journal Article] E3 ligase CHIP and Hsc70 regulate Kv1.5 protein expression and function in mammalian cells.2015
- Author(s)
  Li P, Kurata Y, Maharani N, Mahati E, Higaki K, Hasegawa A, Shirayoshi Y, Yoshida A, Kondo T, Kurozawa Y, Yamamoto K, Ninomiya H, Hisatome I.
- Journal Title
  
  J Mol Cell Cardiol.
  
  Volume: 86 Pages: 138-146
- DOI
  10.1016/j.yjmcc.2015.07.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26501003, KAKENHI-PROJECT-25461109
[Journal Article] Apoptosis induced by an uromodulin mutant C112Y and its suppression by topiroxostat.2014
- Author(s)
  Utami SB, Mahati E, Li P,
- Journal Title
  
  Clin Exp Nephrol.
  
  Volume: Epub ahead of print
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461109
[Journal Article] Instability of KCNE1-D85N that Causes Long QT Syndrome: Stabilization by Verapamil2014
- Author(s)
  Sakata S, Kurata Y, Li P, Notsu T, Morikawa K, Miake J, Higaki K, Yamamoto Y, Yoshida A, Shirayoshi Y, Yamamoto K, Horie M, Ninomiya H, Kanzaki S, Hisatome I.
- Journal Title
  
  Pacing Clinical Electrophysiology
  
  Volume: Epub ahead of print Issue: 7 Pages: 1-11
- DOI
  10.1111/pace.12360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591512, KAKENHI-PROJECT-25461109, KAKENHI-PROJECT-25461387, KAKENHI-PROJECT-25670110, KAKENHI-PROJECT-25893134, KAKENHI-PROJECT-26501003
[Journal Article] AMP deaminase 3 plays a critical role in remote reperfusion lung injury2013
- Author(s)
  Li P, Ogino K, Morikawa K, Shirayoshi Y, Hisatome I, et al.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 431(2) Issue: 1 Pages: 131-6
- DOI
  10.1016/j.bbrc.2013.03.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00001, KAKENHI-PROJECT-25461109, KAKENHI-PROJECT-25893134
[Journal Article] Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins2013
- Author(s)
  Iwai C, P Li,
- Journal Title
  
  Cardiovasc Res
  
  Volume: ３ Issue: 3 Pages: 520-528
- DOI
  10.1093/cvr/cvt200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461109, KAKENHI-PROJECT-25461387, KAKENHI-PROJECT-25670110, KAKENHI-PROJECT-25893134
[Journal Article] Simultaneous Treatment with Azelnidipine and Olmesartan Inhibits Apoptosis of Hl-1 Cardiac Myocytes Expressing E334k cMyBPC2013
- Author(s)
  Bahrudin U, Ikeda N, Utami SB, Maharani N, Morikawa K, Li P
- Journal Title
  
  Drug Res (Stuttg).
  
  Volume: １０ Issue: 10 Pages: 515-520
- DOI
  10.1055/s-0033-1347188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461109, KAKENHI-PROJECT-25670110, KAKENHI-PROJECT-25893134
[Journal Article] Bepridil Suppresses Apoptosis in HL-1 Cardiac Atrial Myocytes Expressing Mutant E334K cMyBPC.2013
- Author(s)
  Endo R, Notsu T, Mishima M, Morikawa K, Li P
- Journal Title
  
  Yonago Acta Med
  
  Volume: Epub
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] キサンチンオキシダーゼ阻害剤の有効性2022
- Author(s)
  桑原政成　浜田紀宏　李佩俐
- Organizer
  第５５回日本痛風　尿酸核酸代謝学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08074
[Presentation] Role of Kv1.5 in monosodium urate crystal-induced activation of NLRP3 inflammasome in mouse cardiomyocyte HL-12022
- Author(s)
  Peili Li
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08074
[Presentation] Activation of NLRP3 inflammasome in mouse cardiomyocyte HL-1 by monosodium urate crystal-stimulated macrophages2022
- Author(s)
  李佩俐
- Organizer
  第５５回日本痛風　尿酸核酸代謝学会総会
- Data Source
  KAKENHI-PROJECT-18K08074
[Presentation] Inhibition of Kv1.5 channels attenuates Monosodium Urate induced NLRP3 inflammasome activation in human macrophages2021
- Author(s)
  Peili Li
- Organizer
  第67回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-18K08074
[Presentation] Monosodium urate crystal-induced NLRP3 inflammasome activation is regulated by Kv1.5 channel2020
- Author(s)
  Li P, Taufiq F, 桑原政成, et al
- Organizer
  第53回日本痛風尿酸核酸学会総会
- Data Source
  KAKENHI-PROJECT-18K08074
[Presentation] Effects of FYU981 on the urate crystal-induced activation of NLRP3 inflammasome in macrophage2020
- Author(s)
  Taufiq F, Li P, 水田栄之助, et al
- Organizer
  第53回日本痛風尿酸核酸学会総会
- Data Source
  KAKENHI-PROJECT-18K08074
[Presentation] Monosodium urate crystal-induced NLRP3 inflammasome activation is regulated by Kv1.5 channel2020
- Author(s)
  Peili Li, Fikri Taufiq
- Organizer
  第53回日本痛風尿酸核酸学会総会
- Data Source
  KAKENHI-PROJECT-18K08074
[Presentation] HDAC6 regulates electrophysiological properties of HL-1 cells via ERG channel2019
- Author(s)
  Peili Li, Yasutaka Kurata, Fikri Taufiq, Yasuaki Shirayoshi, Ichiro Hisatome
- Organizer
  第８３回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08074
[Presentation] Kv1.5 Channels regulate the NLRP3 Inflammasome activation in macrophages induced by monosodium Urate2019
- Author(s)
  Peili Li, Yasutaka Kurata, Fikri Taufiq , Yasuaki Shirayoshi, Ichiro Hisatome
- Organizer
  第66回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-18K08074
[Presentation] Uric Acid-induced Increases of protein and Channel Activity of Atrial Kv1.5 via Akt-HSF1-Hsp70 Axis2019
- Author(s)
  Fikri Taufiq, Nani Maharani, Peili Li
- Organizer
  第８３回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08074
[Presentation] Inhibition of HDAC 6 manipulates electrophysiological properties of HL-1 cells2018
- Author(s)
  Peili Li, et al
- Organizer
  第二回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-18K08074
[Presentation] Inhibition of HDAC 6 manipulates electrophysiological properties of HL-1 cells via regulation of ERG channel2018
- Author(s)
  Peili Li, et al
- Organizer
  第65回不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-18K08074
[Presentation] Effects of class Ⅰantiarrhythmic agents on ionic currents of human iPS cell-derived ventricular myocytes2018
- Author(s)
  Sayaka Yonemizu, Peili Li, et al
- Organizer
  第65回不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-18K08074
[Presentation] Epigenetic and post-translational modification of hERG to control the channel protein expression and function2016
- Author(s)
  Peili Li, et al
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  宮城県仙台市仙台国際センター
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] Hyperuricemia-induced Stabilization of Kv1.52016
- Author(s)
  Maharani Nani, Li Peili, et al.
- Organizer
  第49回日本痛風・核酸代謝学会
- Place of Presentation
  大阪府大阪市大阪千里ライフサイエンスセンター
- Year and Date
  2016-02-18
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] Heat shock factor-1 は変異型A78THERGチャネル蛋白の成熟化に関与する2015
- Author(s)
  近藤健人、李　　佩俐、et al
- Organizer
  第１０７回日本循環器学会中国地方会
- Place of Presentation
  広島県広島市広島アステールプラザ
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] Stabilization of Kv1.5 channel protein by Olprinone2015
- Author(s)
  Ryo Endo, Peili Li, et al.
- Organizer
  第30回日本不整脈学会学術大会　第32回日本心電学会学術集会
- Place of Presentation
  京都府京都市国立京都国際会館
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] Electrophysiological properties of iPS cell-derived cardiomyocytes from a patient with long QT syndrome type 1 harboring a novel mutation of KCNQ12015
- Author(s)
  Yasutaka Kurata, peili Li, et al
- Organizer
  第30回日本不整脈学会学術大会　第32回日本心電学会学術集会
- Place of Presentation
  京都府京都市国立京都国際会館
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] ビルジカイニドの慢性投与によるHERGチャネル増加作用に関する検討2015
- Author(s)
  大野原岳史、久留一郎、李　　佩俐、et al.
- Organizer
  第１０７回日本循環器学会中国地方会
- Place of Presentation
  広島県広島市広島アステールプラザ
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] Electrophysiological properties of iPS cell-derived cardiomyocytes from patients with long QT syndrome type 1 harvoring a novel mutation KCNQ1.2015
- Author(s)
  Yasutaka Kurata, Peili Li, Kumi Morikawa, Junichiro Miake, Kazuhiro Yamamoto, Yasuaki Shirayoshi, Ichiro Hisatome
- Organizer
  第３０回日本不整脈学会学術集会・第３２回日本心電学会学術集会合同学術大会
- Place of Presentation
  国立京都国際会館、京都
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26501003
[Presentation] A novel Double Mutation of hERG protein in LQT2 syndrome: Identification and rescue.2015
- Author(s)
  Endang Mahati, Peili Li, et al
- Organizer
  第30回日本不整脈学会学術大会　第32回日本心電学会学術集会
- Place of Presentation
  京都府京都市国立京都国際会館
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] Histone deacetylase plays a pivotal role in expression and function of wild-type and mutant hERGs2015
- Author(s)
  Peili Li, et al.
- Organizer
  第30回日本不整脈学会学術大会　第32回日本心電学会学術集会
- Place of Presentation
  京都府京都市国立京都国際会館
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] Hsp90 Prevents Interaction between CHIP and HERG Proteins to Facilitate Maturation of Wild-type and Mutant HERG Proteins2014
- Author(s)
  Peili Li, Chisato Iwai
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] Topiroxiostat improved the apoptpsis of cells expressing Uromodulin Mutation C112Y Causing Familial Juvenile Hyperuricemic Nephropathy (FJHN)2014
- Author(s)
  Peili Li , Sulistiyati Bayu Utami,
- Organizer
  第47回日本痛風・核酸代謝学会総会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] ユビキチンリガーゼCHIPに介してHsp90は変異hERG蛋白発現とチャネル活性を改善する2013
- Author(s)
  李佩俐、岩井ちさと
- Organizer
  第103日本循環器学会中国地方会
- Place of Presentation
  米子コンベンションセンター
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] E3 ligase CHIP interacts with Hsc70 to regulate Kv1.5 expression and repolarization in HL-1 cells2013
- Author(s)
  Peili Li, Masaru Kato
- Organizer
  第30回日本心電学会学術集会
- Place of Presentation
  青森市文化会館　ホテル青森
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] The Activity of Urate to Increases Kv1.5 Channel Expression in Atrial Myocytes Depends on Uric acid Transporters, Xanthine Oxidase and ERKs
- Author(s)
  Nani Maharani, Peili li,
- Organizer
  第29回日本不整脈学会・第31回日本心電学会合同学術大会
- Place of Presentation
  東京都港区ザ・プリンスパークタワー東京,プリンスホテル
- Year and Date
  2014-07-22 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25461109
[Presentation] Hsp90 Promotes Maturation of Wild-type and Mutant HERG Proteins
- Author(s)
  Peili Li
- Organizer
  第29回日本不整脈学会・第31回日本心電学会合同学術大会
- Place of Presentation
  東京都港区ザ・プリンスパークタワー東京,プリンスホテル
- Year and Date
  2014-07-22 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25461109
[]

1. Shirayoshi Yasuaki (90249946)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. Ikeda Nobuhito (50620316)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. 久留一郎 (60211504)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. TSUNETO Motokazu (60730207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 森川久未 (90707217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 伊藤敏幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 神崎晋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 倉田康孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 中井彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Li Peili 李 佩俐

Research Projects

Research Products

Co-Researchers

A study of the novel molecular mechanism of atrial fibrillation induced by cardiac resident macrophages in hyperuricemia

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Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytesPrincipal Investigator

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Elucidation of the pathophysiology and etiology of congenital long QT syndrome type 6 by myocardial cell screening and iPS technology

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Fluorescent reporter lines in human iPS cells offer useful platforms to study cardiac subtype specification, cell-based therapies of cardiac disease and drug development.

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The role of Hsp70 in quality control of mutant hERG protein associated LQT2 and its therapeutic application.Principal Investigator

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[Journal Article] α1-Adrenergic receptor mediates adipose-derived stem cell sheet-induced protection against chronic heart failure after myocardial infarction in rats2022

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[Journal Article] Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes2022

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[Journal Article] Early effects of an adipose-derived stem cell sheet against detrusor underactivity in a rat cryo-injury model2022

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[Journal Article] Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease ― Japanese Guideline on the Management of Asymptomatic Hyperuricemia ―2021

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[Journal Article] Novel inhibitory effects of dotinurad, a selective urate reabsorption inhibitor, on urate crystal-induced activation of NLRP3 inflammasomes in macrophages2020

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[Journal Article] Evidence for Urate Uptake Through Monocarboxylate Transporter 9 Expressed in Mammalian Cells and Its Enhancement by Heat Shock2020

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[Journal Article] Inhibitory effects of class I antiarrhythmic agents on Na+ and Ca2+ currents of human iPS cell-derived cardiomyocytes.2019

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[Journal Article] Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes2019

Author(s)

Li Peili 李佩俐

[Journal Article] Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease　― Japanese Guideline on the Management of Asymptomatic Hyperuricemia ―2021