Hara Hideyuki 原英之

… Alternative Names

HARA Hideyuki 原英之

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Researcher Number	40469953
Other IDs
Affiliation (Current)	2025: 大阪大学, 感染症総合教育研究拠点, 特任准教授(常勤)
Affiliation (based on the past Project Information) *help	2023 – 2024: 大阪大学, 感染症総合教育研究拠点, 特任准教授(常勤) 2023: 大阪大学, 感染症総合教育研究拠点, 特任准教授 2021 – 2022: 徳島大学, 先端酵素学研究所, 助教 2017 – 2020: 徳島大学, 先端酵素学研究所(次世代), 助教 2016: 徳島大学, 先端酵素学研究所, 助教 2014 – 2016: 徳島大学, 疾患酵素学研究センター, 助教 2013: 徳島大学, 疾患酵素学研究センター, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Veterinary medical science Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Neurology / General internal medicine and related fields
Keywords	Principal Investigator 神経変性 / プリオン / ネクロトーシス / 異常型 / プリオン病 / 構造変換 / ウイルス感染 / ウイルス / スクレイピー / 狂牛病 … More / クロイツフェルト・ヤコブ病 / 銅 / リピート部位 / OR / オクタペプチドリピート / 銅イオン … More Except Principal Investigator プリオン病 / プリオン / 神経変性 / ソーチリン / インフルエンザウイルス / ポストゴルジ輸送 / ポストゴルジ小胞輸送 / アトラクチン / トランスジェニックマウス / プリオン蛋白質 / プリオンタンパク質 / 神経細胞死 / エタノールアミン / スーパーオキシドジスムターゼ / 銅 / A型インフルエンザウイルス / マクロファージ / Srcファミリーキナーゼ / 銅イオン / 活性酸素種 / Src / スーパーオキサイドジスムターゼ / 抗体 / インフルエンザ / Tgマウス / 細胞膜蛋白質 / 小胞輸送 / インスリン受容体 / 神経変性疾患 / ノックアウトマウス / 蛋白質分解 / 蛋白質輸送 / 狂牛病 / クロイツフェルト・ヤコブ病 / 受容体 / 構造変換 / 感受性 Less

ネクロトーシスに着目したプリオン病の病態解明と治療法創出Principal Investigator
- Principal Investigator
  
  原英之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Studies of prion pathogenesis and non-prion pathogens for preventative and therapeutic development against prion diseases
- Principal Investigator
  
  坂口末廣
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  The University of Tokushima
Elucidation of the mechanism of abnormal prion protein production triggered by necroptosisPrincipal Investigator
- Principal Investigator
  
  HARA Hideyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
  The University of Tokushima
Elucidation of the pathogenic mechanism and screening of therapeutic compounds in prion disease
- Principal Investigator
  
  SAKAGUCHI Suehiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  The University of Tokushima
Construction of prion disease model using neuroblastoma cells and elucidation of the production mechanism of abnormal prion proteinPrincipal Investigator
- Principal Investigator
  
  HARA Hideyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  The University of Tokushima
Prion protein is a target molecule for a novel anti-influenza therapeutic
- Principal Investigator
  
  SAKAGUCHI Suehiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  General internal medicine and related fields
- Research Institution
  The University of Tokushima
Elucidation of the vesicular trafficking mechanism for prion propagation on the basis of our previous findings of the disturbed vesicular trafficking in prion disease
- Principal Investigator
  
  SAKAGUCHI Suehiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokushima
Identification of a host molecule inportant for prion infection
- Principal Investigator
  
  SAKAGUCHI Suehiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  The University of Tokushima
Elucidation of the prion pathogenic decision mechanism through a copper ion binding site of a prion proteinPrincipal Investigator
- Principal Investigator
  
  HARA Hideyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  The University of Tokushima

All 2024 2023 2022 2021 2020 2019 2018 2017 2014 2013 Other

All Journal Article Presentation Book

[Book] ブレインサイエンス・レビュー20212021
- Author(s)
  廣川　信隆、板東　武彦／編、原　英之／9章を分担執筆
- Total Pages
  240
- Publisher
  アドスリー
- ISBN
  9784904419991
- Data Source
  KAKENHI-PROJECT-18K07499
[Book] ブレインサイエンス・レビュー20212021
- Author(s)
  廣川　信隆、板東　武彦／編著、原　英之／分担執筆
- Total Pages
  240
- Publisher
  アドスリー
- ISBN
  9784904419991
- Data Source
  KAKENHI-PROJECT-21K07462
[Journal Article] プリオン病発症のトリガーとしてのウイルス感染2024
- Author(s)
  原英之、坂口末廣
- Journal Title
  
  ファルマシア
  
  Volume: 60 Pages: 36-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27489
[Journal Article] プリオン病発症のトリガーとしてのウイルス感染2024
- Author(s)
  原英之、坂口末廣
- Journal Title
  
  Farumashia
  
  Volume: 60 Issue: 1 Pages: 36-40
- DOI
  10.14894/faruawpsj.60.1_36
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07462
[Journal Article] Strain‐dependent role of copper in prion disease through binding to histidine residues in the N‐terminal domain of prion protein2023
- Author(s)
  Hara Hideyuki、Miyata Hironori、Chida Junji、Sakaguchi Suehiro
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 167 Issue: 3 Pages: 394-409
- DOI
  10.1111/jnc.15971
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08600, KAKENHI-PROJECT-21K07462, KAKENHI-PROJECT-23K27489
[Journal Article] The first non-prion pathogen identified: neurotropic influenza virus2022
- Author(s)
  Sakaguchi Suehiro、Hara Hideyuki
- Journal Title
  
  Prion
  
  Volume: 16 Issue: 1 Pages: 1-6
- DOI
  10.1080/19336896.2021.2015224
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03548, KAKENHI-PROJECT-21K07462
[Journal Article] Central residues in prion protein PrPC are crucial for its conversion into the pathogenic isoform2022
- Author(s)
  Pasiana Agriani Dini、Miyata Hironori、Chida Junji、Hara Hideyuki、Imamura Morikazu、Atarashi Ryuichiro、Sakaguchi Suehiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 9 Pages: 102381-102381
- DOI
  10.1016/j.jbc.2022.102381
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07462, KAKENHI-PROJECT-22K08600
[Journal Article] Vaporized Hydrogen Peroxide and Ozone Gas Synergistically Reduce Prion Infectivity on Stainless Steel Wire2021
- Author(s)
  Hara Hideyuki、Chida Junji、Pasiana Agriani Dini、Uchiyama Keiji、Kikuchi Yutaka、Naito Tomoko、Takahashi Yuichi、Yamamura Junji、Kuromatsu Hisashi、Sakaguchi Suehiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 6 Pages: 3268-3268
- DOI
  10.3390/ijms22063268
- NAID
  120007164927
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07499, KAKENHI-PROJECT-19K08930, KAKENHI-PROJECT-19H03548
[Journal Article] Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells2021
- Author(s)
  Hara Hideyuki、Chida Junji、Uchiyama Keiji、Pasiana Agriani Dini、Takahashi Etsuhisa、Kido Hiroshi、Sakaguchi Suehiro
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 10109-10109
- DOI
  10.1038/s41598-021-89586-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08930, KAKENHI-PROJECT-19H03548, KAKENHI-PROJECT-21K07462
[Journal Article] Virus Infection, Genetic Mutations, and Prion Infection in Prion Protein Conversion2021
- Author(s)
  Hara Hideyuki、Sakaguchi Suehiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 22 Pages: 12439-12439
- DOI
  10.3390/ijms222212439
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03548, KAKENHI-PROJECT-21K07462
[Journal Article] Ethanolamine Is a New Anti-Prion Compound2021
- Author(s)
  Uchiyama Keiji、Hara Hideyuki、Chida Junji、Pasiana Agriani Dini、Imamura Morikazu、Mori Tsuyoshi、Takatsuki Hanae、Atarashi Ryuichiro、Sakaguchi Suehiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 21 Pages: 11742-11742
- DOI
  10.3390/ijms222111742
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08930, KAKENHI-PROJECT-19H03548, KAKENHI-PROJECT-20K07807, KAKENHI-PROJECT-21K07462
[Journal Article] The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region.2020
- Author(s)
  Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Junji Chida, Keiji Uchiyama, Kentaro Masujin, Hitomi Watanabe, Gen Kondoh, Suehiro Sakaguchi
- Journal Title
  
  Molecular Neurobiology
  
  Volume: 57 Pages: 1203-1216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03548
[Journal Article] Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice2020
- Author(s)
  Chida Junji、Hara Hideyuki、Uchiyama Keiji、Takahashi Etsuhisa、Miyata Hironori、Kosako Hidetaka、Tomioka Yukiko、Ito Toshihiro、Horiuchi Hiroyuki、Matsuda Haruo、Kido Hiroshi、Sakaguchi Suehiro
- Journal Title
  
  PLOS Pathogens
  
  Volume: 16 Issue: 8 Pages: e1008823-e1008823
- DOI
  10.1371/journal.ppat.1008823
- NAID
  120006956844
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08930, KAKENHI-PROJECT-19H03548, KAKENHI-PROJECT-18K07499
[Journal Article] N-Terminal Regions of Prion Protein: Functions and Roles in Prion Diseases2020
- Author(s)
  Hara Hideyuki、Sakaguchi Suehiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 17 Pages: 6233-6233
- DOI
  10.3390/ijms21176233
- NAID
  120006959719
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03548, KAKENHI-PROJECT-18K07499
[Journal Article] The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region2020
- Author(s)
  †Das Rani Nandita, †Miyata Hironori, †Hara Hideyuki, Chida Junji, Uchiyama Keiji, Masujin Kentaro, Watanabe Hitomi, Kondoh Gen, Sakaguchi Suehiro, †equally contribution
- Journal Title
  
  Mol Neurobiol.
  
  Volume: 57 Issue: 2 Pages: 1203-1216
- DOI
  10.1007/s12035-019-01804-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07499
[Journal Article] Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91?1062020
- Author(s)
  Uchiyama Keiji、Miyata Hironori、Yamaguchi Yoshitaka、Imamura Morikazu、Okazaki Mariya、Pasiana Agriani Dini、Chida Junji、Hara Hideyuki、Atarashi Ryuichiro、Watanabe Hitomi、Kondoh Gen、Sakaguchi Suehiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 19 Pages: 7260-7260
- DOI
  10.3390/ijms21197260
- NAID
  120006959718
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08930, KAKENHI-PROJECT-19H03548, KAKENHI-PROJECT-18K07499
[Journal Article] Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys2019
- Author(s)
  Hagiwara Ken’ichi、Sato Yuko、Yamakawa Yoshio、Hara Hideyuki、Tobiume Minoru、Okemoto-Nakamura Yuko、Sata Tetsutaro、Horiuchi Motohiro、Shibata Hiroaki、Ono Fumiko
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 5 Pages: e0216807-e0216807
- DOI
  10.1371/journal.pone.0216807
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06621, KAKENHI-PROJECT-18K07499
[Journal Article] Prion protein protects mice from lethal infection with influenza A viruses2018
- Author(s)
  Chida Junji、Hara Hideyuki、Yano Masashi、Uchiyama Keiji、Das Nandita Rani、Takahashi Etsuhisa、Miyata Hironori、Tomioka Yukiko、Ito Toshihiro、Kido Hiroshi、Sakaguchi Suehiro
- Journal Title
  
  PLOS Pathogens
  
  Volume: 14 Issue: 5 Pages: e1007049-e1007049
- DOI
  10.1371/journal.ppat.1007049
- NAID
  120006524496
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07499, KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-16H05348, KAKENHI-PROJECT-16K10029, KAKENHI-PROJECT-17K19661
[Journal Article] Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice.2017
- Author(s)
  Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Keiji Uchiyama, Junji Chida, Masashi Yano, Hitomi Watanabe, Gen Kondoh, Suehiro Sakaguchi
- Journal Title
  
  Archives of Virology
  
  Volume: 印刷中 Issue: 7 Pages: 1867-1876
- DOI
  10.1007/s00705-017-3295-3
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01560, KAKENHI-PROJECT-26293212, KAKENHI-PROJECT-15K15380, KAKENHI-PROJECT-15K21098, KAKENHI-PROJECT-16K10029, KAKENHI-PROJECT-17K08859
[Journal Article] Melanin or melanin-like substance interacts with the N-terminal portion of prion protein and inhibits abnormal prion protein formation in prion-infected cells.2017
- Author(s)
  Taichi Hamanaka, Keiko Nishizawa, Yuji Sakasegawa, Ayumi Oguma, Kenta Teruya, Hiroshi Kurahashi, Hideyuki Hara, Suehiro Sakaguchi, Katsumi Doh-ura
- Journal Title
  
  Journal of Virology
  
  Volume: 印刷中 Issue: 6
- DOI
  10.1128/jvi.01862-16
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01560, KAKENHI-PROJECT-16H05317, KAKENHI-PROJECT-26293212, KAKENHI-PROJECT-15K15380, KAKENHI-PROJECT-15K01804
[Journal Article] Mouse-hamster chimeric prion protein (PrP) devoid of N-terminal residues 23-88 restores susceptibility to 22L prions, but not to RML prions in PrP-knockout mice.2014
- Author(s)
  Uchiyama K, Miyata H, Yano M, Yamaguchi Y, Imamura M, Muramatsu N, Das NR, Chida J, Hara H, Sakaguchi S.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 10 Pages: e109737-e109737
- DOI
  10.1371/journal.pone.0109737
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25870474, KAKENHI-PROJECT-25870479, KAKENHI-PROJECT-26460557
[Journal Article] Species-barrier phenomenon in prion transmissibility from a viewpoint of protein science2013
- Author(s)
  Hagiwara, K., Hara, H., and Hanada, K.
- Journal Title
  
  J. Biochem.
  
  Volume: 153 Issue: 2 Pages: 139-145
- DOI
  10.1093/jb/mvs148
- NAID
  40019566388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870479
[Journal Article] 「プリオン仮説」の最終証明に挑戦しませんか？2013
- Author(s)
  原　英之
- Journal Title
  
  生物工学会誌
  
  Volume: 91 Pages: 471-471
- Data Source
  KAKENHI-PROJECT-25870479
[Presentation] 非アルコール性脂肪肝炎モデルマウスへの抗プリオン抗体投与で肝炎と線維化が軽減する2023
- Author(s)
  千田淳司, 原英之, 清水真祐子, Betzaya Bathuluun, 常山幸一, 坂口末廣
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K27489
[Presentation] ネクロトーシスをトリガーとした異常型プリオン蛋白質産生の分子機構2022
- Author(s)
  原　英之、千田　淳司、坂口　末廣
- Organizer
  第45回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07462
[Presentation] インフルエンザウイルス感染は神経細胞において感染性プリオンの産生を引き起こす2021
- Author(s)
  原　英之、千田　淳司、坂口　末廣
- Organizer
  第 44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03548
[Presentation] インフルエンザウイルス感染は神経細胞において感染性プリオンの産生を引き起こす2021
- Author(s)
  原　英之、千田　淳司、坂口　末廣
- Organizer
  第44回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07462
[Presentation] プリオン蛋白質はインフルエンザAウイルス感染による重症化を軽減する2019
- Author(s)
  千田　淳司、原　英之、坂口　末廣
- Organizer
  第 42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03548
[Presentation] ウイルス感染を用いたプリオン病発症機構の解明2019
- Author(s)
  原　英之、千田　淳司、坂口　末廣
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K07499
[Presentation] ウイルス感染を用いたプリオン病発症機構の解明2019
- Author(s)
  原　英之、千田　淳司、坂口　末廣
- Organizer
  第 42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03548
[Presentation] インフルエンザウイルス感染は神経細胞において異常型プリオン産生のトリガーとなる2018
- Author(s)
  原　英之、千田　淳司、坂口　末廣
- Organizer
  第 40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K19661
[Presentation] インフルエンザウイルス感染は神経細胞において異常型プリオン産生のトリガーとなる2018
- Author(s)
  原英之、千田淳司、坂口末廣
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K07499
[Presentation] プリオン蛋白質はインフルエンザAウイルス感染に防御的に機能する2018
- Author(s)
  千田　淳司、原　英之、坂口　末廣
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19661
[Presentation] プリオン蛋白質はインフルエンザAウイルスの感染を制御する2017
- Author(s)
  千田淳司、原英之、坂口末廣
- Organizer
  2017年度生命科学系学会合同年次大会 (ConBio2017)
- Data Source
  KAKENHI-PROJECT-17K19661
[Presentation] 肺で発現する正常プリオン蛋白質の機能解析2017
- Author(s)
  千田淳司、原英之、坂口末廣
- Organizer
  第３２回中国四国ウイルス研究会
- Data Source
  KAKENHI-PROJECT-17K19661
[Presentation] 超好熱菌由来プロテアーゼによるプリオンタンパク質分解の評価
- Author(s)
  古賀雄一、清水七海、作道章一、原英之、坂口末廣、金谷茂則
- Organizer
  第66回日本生物工学会大会,
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2014-09-09 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-25870479
[Presentation] 超好熱菌由来プロテアーゼによるプリオンタンパク質分解の評価
- Author(s)
  清水七海、古賀雄一、作道章一、原英之、坂口末廣、金谷茂則
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都国際会館（京都府・京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25870479

1. SAKAGUCHI Suehiro (60274635)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
2. 千田淳司 (20437651)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
3. 矢野雅司 (10531858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 萩原健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Hideyuki 原 英之

HARA Hideyuki 原 英之

Research Projects

Research Products

Co-Researchers

ネクロトーシスに着目したプリオン病の病態解明と治療法創出Principal Investigator

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Studies of prion pathogenesis and non-prion pathogens for preventative and therapeutic development against prion diseases

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Elucidation of the mechanism of abnormal prion protein production triggered by necroptosisPrincipal Investigator

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Elucidation of the pathogenic mechanism and screening of therapeutic compounds in prion disease

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Construction of prion disease model using neuroblastoma cells and elucidation of the production mechanism of abnormal prion proteinPrincipal Investigator

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Prion protein is a target molecule for a novel anti-influenza therapeutic

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Elucidation of the vesicular trafficking mechanism for prion propagation on the basis of our previous findings of the disturbed vesicular trafficking in prion disease

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Identification of a host molecule inportant for prion infection

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Elucidation of the prion pathogenic decision mechanism through a copper ion binding site of a prion proteinPrincipal Investigator

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[Book] ブレインサイエンス・レビュー20212021

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[Book] ブレインサイエンス・レビュー20212021

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[Journal Article] プリオン病発症のトリガーとしてのウイルス感染2024

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[Journal Article] プリオン病発症のトリガーとしてのウイルス感染2024

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Hara Hideyuki 原英之

HARA Hideyuki 原英之