KAWASHIMA SHIGEHIRO 川島茂裕

… Alternative Names

Kawashima Shigehiro 川島茂裕

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Researcher Number	40508115
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院薬学系研究科(薬学部), 准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 東京大学, 大学院薬学系研究科(薬学部), 准教授 2020 – 2021: 東京大学, 大学院薬学系研究科(薬学部), 特任准教授 2016 – 2020: 東京大学, 大学院薬学系研究科(薬学部), 特任講師 2015: 東京大学, 薬学研究科(研究院), 講師 2014: 東京大学, 薬学研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 37030:Chemical biology-related / Medium-sized Section 37:Biomolecular chemistry and related fields / Biological Sciences / Molecular biology Except Principal Investigator Transformative Research Areas, Section (II) / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator ヒストン / 触媒 / クロマチン / アシル化 / アセチル化 / 化学修飾 / オンコヒストン / CPP / エピゲノム / AAA+タンパク質で … More / 阻害剤 / 低分子化合物 / 低分子阻害剤 / ミダシン / リボソーム生合成 / ヌクレオソーム / 人工触媒システム / エピジェネティクス / 人工触媒 / サーチュイン / 人工化学触媒 / 細胞周期 / 染色体分配 / 低グルコース / 分裂酵母 / グルコース / マロニル化 / Bub1キナーゼ / 酵母 / サブテロメア / セントロメア / リン酸化 / シュゴシン / 染色体 … More Except Principal Investigator エクソソーム / 膜動態 / 生体共役反応 / 糖鎖 / 膜タンパク質 / 生体適合化学 / アシル化 / 染色体 / ヒストンアシル化 / エピゲノム修飾 / アシル化触媒 / エピゲノム修復 / DNA損傷 / ヒストン修飾 / エピジェネティク修飾 / エピジェネティクス / DNA修復 / DNA / ヒストン / 触媒 Less

アミロイドLLPSを標的とした化学触媒の開発Principal Investigator
- Principal Investigator
  
  川島茂裕
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  The University of Tokyo
エピコードを操作する化学触媒の開発Principal Investigator
- Principal Investigator
  
  川島茂裕
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
Development of innovative chemical modification techniques to detoxify oncohistonesPrincipal Investigator
- Principal Investigator
  
  川島茂裕
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Chemical glycan modification of membrane proteins for "manipulating" membrane dynamics
- Principal Investigator
  
  Kounosuke Oisaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  National Institute of Advanced Industrial Science and Technology
  The University of Tokyo
Development of chemical catalyst enabling epigenome manipulationPrincipal Investigator
- Principal Investigator
  
  川島茂裕
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  The University of Tokyo
Relationships between histone epigenetic modifications and DNA damage repair
- Principal Investigator
  
  Kanai Motomu
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Discovery and analysis of novel small molecules targeting human Midasin proteinsPrincipal Investigator
- Principal Investigator
  
  Kawashima Shigehiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  The University of Tokyo
人工触媒システムを用いたヒストンアシル化の機能解析Principal Investigator
- Principal Investigator
  
  川島茂裕
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Studying molecular mechanisms of centromeric localization of ShugoshinPrincipal Investigator
- Principal Investigator
  
  Kawashima Shigehiro
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo

All 2022 2021 2020 2019 2018 2017 2016 2014

All Journal Article Presentation Patent

[Journal Article] Live Cell Synthetic Histone Acetylation by Chemical Catalyst2022
- Author(s)
  Kawashima Shigehiro A.、Kanai Motomu
- Journal Title
  
  Chromosome Analysis
  
  Volume: 0000 Pages: 155-161
- DOI
  10.1007/978-1-0716-2433-3_17
- ISBN
  9781071624326, 9781071624333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0179, KAKENHI-PROJECT-20H00489, KAKENHI-PROJECT-23K21157
[Journal Article] Improving Drug Sensitivity of HIV-1 Protease Inhibitors by Restriction of Cellular Efflux System in a Fission Yeast Model2022
- Author(s)
  Zhang Jiantao、Li Qi、Kawashima Shigehiro A.、Nasr Mohamed、Xue Fengtian、Zhao Richard Y.
- Journal Title
  
  Pathogens
  
  Volume: 11 Issue: 7 Pages: 804-804
- DOI
  10.3390/pathogens11070804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21157
[Journal Article] Live-Cell Protein Modification by Boronate-Assisted Hydroxamic Acid Catalysis2021
- Author(s)
  Adamson Christopher、Kajino Hidetoshi、Kawashima Shigehiro A.、Yamatsugu Kenzo、Kanai Motomu
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 37 Pages: 14976-14980
- DOI
  10.1021/jacs.1c07060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21472, KAKENHI-PROJECT-19KK0179, KAKENHI-PROJECT-20H00489, KAKENHI-PROJECT-23K21157
[Journal Article] Live-cell epigenome manipulation by synthetic histone acetylation catalyst system2021
- Author(s)
  Fujiwara Yusuke、Yamanashi Yuki、Fujimura Akiko、Sato Yuko、Kujirai Tomoya、Kurumizaka Hitoshi、Kimura Hiroshi、Yamatsugu Kenzo、Kawashima Shigehiro A.、Kanai Motomu
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 4
- DOI
  10.1073/pnas.2019554118
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05527, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-17H01417, KAKENHI-PROJECT-19KK0179, KAKENHI-PROJECT-20H00489, KAKENHI-PROJECT-23K21157
[Journal Article] A Single-Step Asymmetric Phosphodiester Synthesis from Alcohols with Phosphoenolpyruvate Phosphodiester2021
- Author(s)
  Yamatsugu Kenzo、Kanai Motomu、Fujiyoshi Kohei、Kawashima Shigehiro A.
- Journal Title
  
  Synlett
  
  Volume: 32 Issue: 11 Pages: 1135-1140
- DOI
  10.1055/a-1509-9275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00489, KAKENHI-PROJECT-23K21157
[Journal Article] Hydroxamic Acid‐Piperidine Conjugate is an Activated Catalyst for Lysine Acetylation under Physiological Conditions2020
- Author(s)
  Mizumoto Shinsuke、Xi Siqi、Fujiwara Yusuke、Kawashima Shigehiro A.、Yamatsugu Kenzo、Kanai Motomu
- Journal Title
  
  Chemistry - An Asian Journal
  
  Volume: 15 Issue: 6 Pages: 833-839
- DOI
  10.1002/asia.201901737
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04536, KAKENHI-PROJECT-17K19479, KAKENHI-PROJECT-19KK0179, KAKENHI-PROJECT-20H00489
[Journal Article] Synthetic hyperacetylation of nucleosomal histones2020
- Author(s)
  Kajino Hidetoshi、Nagatani Tomomi、Oi Miku、Kujirai Tomoya、Kurumizaka Hitoshi、Nishiyama Atsuya、Nakanishi Makoto、Yamatsugu Kenzo、Kawashima Shigehiro A.、Kanai Motomu
- Journal Title
  
  RSC Chemical Biology
  
  Volume: 1 Issue: 2 Pages: 56-59
- DOI
  10.1039/d0cb00029a
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04536, KAKENHI-PROJECT-20K21497, KAKENHI-PROJECT-19KK0179, KAKENHI-ORGANIZER-19H05739, KAKENHI-PLANNED-19H05740, KAKENHI-PROJECT-20H00489, KAKENHI-PROJECT-18K19138
[Journal Article] Site-Selective Synthetic Acylation of a Target Protein in Living Cells Promoted by a Chemical Catalyst/Donor System.2019
- Author(s)
  Hamajima W, Fujimura A, Fujiwara Y, Yamatsugu K, Kawashima SA, Kanai M.
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 14 Issue: 6 Pages: 1102-1109
- DOI
  10.1021/acschembio.9b00102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19138, KAKENHI-PROJECT-17K19479, KAKENHI-PUBLICLY-18H04536, KAKENHI-PROJECT-17H01522
[Journal Article] Bub1 kinase- and H2A phosphorylation-independent regulation of Shugoshin proteins under glucose-restricted conditions.2019
- Author(s)
  Kobayashi Y, Kawashima SA
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 2826-2826
- DOI
  10.1038/s41598-019-39479-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19138, KAKENHI-PROJECT-26711001
[Journal Article] Leading approaches in synthetic epigenetics for novel therapeutic strategies2018
- Author(s)
  Yamatsugu Kenzo、Kawashima Shigehiro A、Kanai Motomu
- Journal Title
  
  Current Opinion in Chemical Biology
  
  Volume: 46 Pages: 10-17
- DOI
  10.1016/j.cbpa.2018.03.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19479, KAKENHI-PUBLICLY-16H01300, KAKENHI-PROJECT-17H01522
[Journal Article] Malonylation of histone H2A at lysine 119 inhibits Bub1-dependent H2A phosphorylation and chromosomal localization of shugoshin proteins2018
- Author(s)
  Ishiguro Tadashi、Tanabe Kana、Kobayashi Yuki、Mizumoto Shinsuke、Kanai Motomu、Kawashima Shigehiro A.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 7671-7680
- DOI
  10.1038/s41598-018-26114-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19479, KAKENHI-PROJECT-18K19138, KAKENHI-PROJECT-26711001
[Journal Article] LC-MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes2018
- Author(s)
  Tanabe Kana、Liu Jiaan、Kato Daiki、Kurumizaka Hitoshi、Yamatsugu Kenzo、Kanai Motomu、Kawashima Shigehiro A.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 2656-2656
- DOI
  10.1038/s41598-018-21060-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26711001, KAKENHI-PLANNED-17H06442, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-16J06850, KAKENHI-PROJECT-17K19479, KAKENHI-PUBLICLY-16H01300
[Journal Article] Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis.2018
- Author(s)
  Chen Z, Suzuki H, Kobayashi Y, Wang AC, DiMaio F, Kawashima SA, Walz T, Kapoor TM.
- Journal Title
  
  Cell
  
  Volume: 175 Issue: 3 Pages: 822-834
- DOI
  10.1016/j.cell.2018.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19138, KAKENHI-PROJECT-26711001
[Journal Article] Synthetic Posttranslational Modifications: Chemical Catalyst-Driven Regioselective Histone Acylation of Native Chromatin2017
- Author(s)
  Amamoto Yoshifumi、Aoi Yuki、Nagashima Nozomu、Suto Hiroki、Yoshidome Daisuke、Arimura Yasuhiro、Osakabe Akihisa、Kato Daiki、Kurumizaka Hitoshi、Kawashima Shigehiro A.、Yamatsugu Kenzo、Kanai Motomu
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 139 Issue: 22 Pages: 7568-7576
- DOI
  10.1021/jacs.7b02138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19479, KAKENHI-PROJECT-17K15043, KAKENHI-PROJECT-26711001, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-15J09028, KAKENHI-PROJECT-15J12397, KAKENHI-PROJECT-16J06850, KAKENHI-PROJECT-17J07303, KAKENHI-PUBLICLY-16H01300
[Journal Article] Synthetic Chromatin Acylation by an Artificial Catalyst System2017
- Author(s)
  Ishiguro Tadashi、Amamoto Yoshifumi、Tanabe Kana、Liu Jiaan、Kajino Hidetoshi、Fujimura Akiko、Aoi Yuki、Osakabe Akihisa、Horikoshi Naoki、Kurumizaka Hitoshi、Yamatsugu Kenzo、Kawashima Shigehiro A.、Kanai Motomu
- Journal Title
  
  Chem
  
  Volume: 2 Issue: 6 Pages: 840-859
- DOI
  10.1016/j.chempr.2017.04.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19479, KAKENHI-PROJECT-26711001, KAKENHI-PROJECT-15J09028, KAKENHI-PROJECT-15J12397, KAKENHI-PUBLICLY-16H01300
[Journal Article] Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis2016
- Author(s)
  Shigehiro A. Kawashima, Zhen Chen, Yuki Aoi, Anupam Patgiri, Yuki Kobayashi, Paul Nurse and Tarun M. Kapoor
- Journal Title
  
  Cell
  
  Volume: 167 Issue: 2 Pages: 512-524
- DOI
  10.1016/j.cell.2016.08.070
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J09028, KAKENHI-PUBLICLY-16H01300, KAKENHI-PROJECT-26711001
[Journal Article] Optimization of the analogue-sensitive Cdc2/Cdk1 mutant by in vivo selection eliminates physiological limitations to its use in cell cycle analysis2014
- Author(s)
  Yuki Aoi, Shigehiro A. Kawashima, Viesturs Simanis, Masayuki Yamamoto, *Masamitsu Sato
- Journal Title
  
  Open Biology
  
  Volume: 4 Issue: 7 Pages: 140063-140063
- DOI
  10.1098/rsob.140063
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25291041, KAKENHI-PROJECT-26711001
[Patent] 選択的な染色体タンパク質のアシル化を行うための人工触媒システム2016
- Inventor(s)
  金井求、川島茂裕、(他７名）
- Industrial Property Rights Holder
  金井求、川島茂裕、(他７名）
- Industrial Property Rights Type
  特許
- Filing Date
  2016
- Overseas
- Data Source
  KAKENHI-PUBLICLY-16H01300
[Presentation] Bub1 および H2A リン酸化に依存しないシュゴシンの染色体局在化2019
- Author(s)
  川島茂裕、小林由紀
- Organizer
  第36回染色体ワークショップ第17 回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-26711001
[Presentation] Bub1 および H2A リン酸化に依存しないシュゴシンの染色体局在化2019
- Author(s)
  川島茂裕、小林由紀
- Organizer
  第 36 回染色体ワークショップ第 17 回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-18K19138
[Presentation] Bub1およびH2Aリン酸化に依存しないシュゴシンの染色体局在化機構2018
- Author(s)
  川島茂裕、小林由紀
- Organizer
  酵母遺伝学フォーラム第51回研究報告会
- Data Source
  KAKENHI-PROJECT-26711001
[Presentation] ヒストンH2Aリジン119番のマロニル化は Bub1によるH2Aリン酸化及びシュゴシンタンパク質の染色体局在化を阻害する2018
- Author(s)
  川島茂裕、石黒;伸茂、田辺佳奈、小林由紀、水本真介、金井求
- Organizer
  第12回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-26711001
[Presentation] ヒストンH2Aリジン119番のマロニル化はBub1によるH2Aリン酸化及びシュゴシンタンパク質の染色体局在化を阻害する2018
- Author(s)
  川島茂裕、石黒伸茂、田辺佳奈、小林由紀、水本真介、金井求
- Organizer
  第12回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-18K19138
[Presentation] 薬剤感受性分裂酵母を用いた化学遺伝学スクリーニングによるリボソーム生合成を標的にした新規低分子阻害剤の同定2017
- Author(s)
  川島茂裕、青井勇樹、Zhen Chen、Tarun M. Kapoor
- Organizer
  日本ケミカルバイオロジー学会第12回年会
- Data Source
  KAKENHI-PUBLICLY-16H01300
[Presentation] Histone H2A-K119 Malonylation Inhibits Bub1-Dependent H2A Phosphorylation and Chromosomal Shugoshin Localization2017
- Author(s)
  Tadashi Ishiguro, Yuki Kobayashi, Kana Tanabe, Kenzo Yamatsugu, Motomu Kanai, Shigehiro Kawashima
- Organizer
  The 9th International Fission Yeast Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26711001
[Presentation] 触媒医療の実現に向けて：人工触媒システムによるヒストンの合成的アシル化（１）2017
- Author(s)
  川島茂裕、山次健三
- Organizer
  日本薬学会第１３７年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01300
[Presentation] ヒストン翻訳後修飾を導入する人工触媒システムの開発2017
- Author(s)
  川島茂裕
- Organizer
  第11回日本エピジェネティクス研究会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01300
[Presentation] リボソーム生合成に必須なAAA+タンパク質Midasinの低分子阻害剤の同定と機能解析2017
- Author(s)
  川島茂裕, Zhen Chen, 青井勇樹, 小林由紀, Tarun M. Kapoor
- Organizer
  2017年酵母遺伝学フォーラム
- Data Source
  KAKENHI-PROJECT-26711001
[Presentation] 生細胞内ヒストン残基選択的アセチル化を目指した人工触媒リガンドの開発2017
- Author(s)
  藤村亜紀子、嵯峨裕、青井勇樹、川島茂裕、山次健三、金井求
- Organizer
  日本ケミカルバイオロジー学会第12回年会
- Data Source
  KAKENHI-PUBLICLY-16H01300
[Presentation] 薬剤感受性分裂酵母を用いた化学遺伝学的スクリーニング系の構築と新規低分子阻害剤の同定2017
- Author(s)
  川島茂裕
- Organizer
  第193回酵母細胞研究会例会
- Invited
- Data Source
  KAKENHI-PROJECT-26711001
[Presentation] Discovery of Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis using Drug-hypersensitive Fission Yeast2017
- Author(s)
  Shigehiro Kawashima、Zhen Chen、Yuki Aoi、Yuki Kobayashi、Paul Nurse、Tarun M. Kapoor
- Organizer
  9th International Fission Yeast Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01300
[Presentation] 薬剤感受性分裂酵母を用いた化学遺伝学的スクリーニング系の構築と新規低分子阻害剤の同定2017
- Author(s)
  川島茂裕
- Organizer
  酵母研究若手の会第３回研究会
- Data Source
  KAKENHI-PROJECT-26711001
[Presentation] リボソーム生合成に必須なAAA+タンパク質Midasinの生化学的解析及び低分子阻害剤の同定2017
- Author(s)
  川島茂裕, Zhen Chen, 青井勇樹, 小林由紀, Tarun M. Kapoor
- Organizer
  第19 回日本RNA 学会年会
- Data Source
  KAKENHI-PROJECT-26711001
[Presentation] ヒストン選択的アセチル化触媒系の生細胞応用2017
- Author(s)
  梶野英俊、藤村亜紀子、石黒伸茂、田辺佳奈、天本義史、加藤大貴、越坂部晃永、胡桃坂仁志、山次健三、川島茂裕、金井求
- Organizer
  日本ケミカルバイオロジー学会第12回年会
- Data Source
  KAKENHI-PUBLICLY-16H01300
[Presentation] Bub1キナーゼによるヒストンH2Aのリン酸化はグルコース制限下におけるシュゴシンの染色体局在には必要ない2017
- Author(s)
  川島茂裕、小林由紀
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-26711001
[Presentation] 薬剤感受性分裂酵母を用いた化学遺伝学スクリーニングによるリボソーム生合成を標的にした新規低分子阻害剤の同定2017
- Author(s)
  川島茂裕、青井勇樹、Zhen Chen、Tarun M. Kapoor
- Organizer
  日本ケミカルバイオロジー学会第12回年会
- Data Source
  KAKENHI-PROJECT-26711001
[Presentation] 人工触媒系SynCAcシステムを用いたヒストンへの多様なアシル化の導入と生化学的特性変化の評価2017
- Author(s)
  藤原侑亮、石黒伸茂、劉家安、田辺佳奈、加藤大貴、胡桃坂仁志、山次健三、川島茂裕、金井求
- Organizer
  日本ケミカルバイオロジー学会第12回年会
- Data Source
  KAKENHI-PUBLICLY-16H01300
[Presentation] Potent, reversible and specific chemical inhibitors of eukaryotic ribosome biogenesis2017
- Author(s)
  Shigehiro A. Kawashima
- Organizer
  THE 43rd NAITO CONFERENCE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26711001
[Presentation] Developing artificial catalyst systems for synthetic histone acylation2016
- Author(s)
  Shigehiro Kawashima、Yoshifumi Amamoto、Tadashi Ishiguro、Kana Tanabe、 Nozomu Nagashima、Yuki Aoi、Jiaan Liu、Hitoshi Kurumizaka、Kenzo Yamatsugu,、Motomu Kanai
- Organizer
  Cold Spring harber laboratory meeting: EPIGENETICS & CHROMATIN
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01300
[Presentation] 人工触媒システムを用いたクロマチン修飾2016
- Author(s)
  川島茂裕
- Organizer
  第16回日本蛋白質科学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01300
[Presentation] Developing fission yeast for chemical biology2016
- Author(s)
  川島茂裕
- Organizer
  2016酵母ルネッサンス
- Invited
- Data Source
  KAKENHI-PROJECT-26711001
[Presentation] リボソーム生合成に必須なAAA+タンパク質ミダシンの特異的かつ可逆的低分子阻害剤の発見2016
- Author(s)
  川島茂裕, Zhen Chen, 青井勇樹, 小林由紀, Paul Nurse, Tarun M. Kapoor
- Organizer
  第39回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-26711001
[Presentation] Developing artificial catalyst systems for synthetic epigenetics2016
- Author(s)
  Shigehiro Kawashima
- Organizer
  The 21st iCeMS International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01300
[Presentation] Developing fission yeast for chemical biology2016
- Author(s)
  川島茂裕
- Organizer
  2016酵母ルネッサンス
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01300
[Presentation] ヒストンH2Aマロニル化はBub1によるH2Aのリン酸化を抑制する2016
- Author(s)
  石黒伸茂、小林由紀、田辺佳奈、山次健三、川島茂裕、金井求
- Organizer
  第33回染色体ワークショップ・第14回核ダイナミクス研究会
- Place of Presentation
  松島一の坊（宮城県宮城郡）
- Year and Date
  2016-01-12
- Data Source
  KAKENHI-PROJECT-26711001

1. Kanai Motomu (20243264)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. Kounosuke Oisaki (00583999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 山次健三 (30646807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 藤村亜紀子 (80793091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 山梨祐輝 (40979150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ITO YUMA

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. SATO Masamitsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 木村宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWASHIMA SHIGEHIRO 川島 茂裕

Kawashima Shigehiro 川島 茂裕

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アミロイドLLPSを標的とした化学触媒の開発Principal Investigator

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エピコードを操作する化学触媒の開発Principal Investigator

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Development of innovative chemical modification techniques to detoxify oncohistonesPrincipal Investigator

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Chemical glycan modification of membrane proteins for "manipulating" membrane dynamics

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Development of chemical catalyst enabling epigenome manipulationPrincipal Investigator

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Relationships between histone epigenetic modifications and DNA damage repair

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Discovery and analysis of novel small molecules targeting human Midasin proteinsPrincipal Investigator

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人工触媒システムを用いたヒストンアシル化の機能解析Principal Investigator

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Studying molecular mechanisms of centromeric localization of ShugoshinPrincipal Investigator

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[Journal Article] Live Cell Synthetic Histone Acetylation by Chemical Catalyst2022

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[Journal Article] Improving Drug Sensitivity of HIV-1 Protease Inhibitors by Restriction of Cellular Efflux System in a Fission Yeast Model2022

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[Journal Article] Live-Cell Protein Modification by Boronate-Assisted Hydroxamic Acid Catalysis2021

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[Journal Article] Live-cell epigenome manipulation by synthetic histone acetylation catalyst system2021

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KAWASHIMA SHIGEHIRO 川島茂裕

Kawashima Shigehiro 川島茂裕