Ichihara Eiki 市原英基

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ICHIHARA Eiki 市原英基

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Researcher Number	40549705
Other IDs
Affiliation (Current)	2025: 岡山大学, 医療開発領域, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 岡山大学, 大学病院, 講師 2011 – 2012: 岡山大学, 医歯(薬)学総合研究科, 講師 2011 – 2012: 岡山大学, 大学院・医歯薬学総合研究科, 講師
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator 非小細胞肺癌 / CDK4/6 / ROS1 / ALK / EGFR / RB / SHP2 / tolerance / 分子標的治療 / 肺癌 / ALK阻害薬 … More Except Principal Investigator … More (1)含鉄蛋白質 / 体内被曝 / 含鉄蛋白 / ラット / プリミティブマントル正規化微量原素パターン / 発癌 / 鉄 / 生体内被曝 / ラジウム / 悪性中皮腫 / 非閉塞性肺疾患癌 / mTOR阻害薬 / BIBW2552 / JAK1/2阻害薬 / everolimus / ｍTOR阻害薬 / 遺伝子改変マウス / 用量依存性 / gefitinib / AZD1480 / everolims / EGFR / NNK / Ogg1ホモノックアウトマウス / bevacizumab / cetuximab / JAK-1/2 inhibitors / everolimus (mTOR阻害薬), / afatinib / EGFR遺伝子改変マウス Less

Development of lung cancer treatment targeting drug tolerance by SHP2.Principal Investigator
- Principal Investigator
  
  Ichihara Eiki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Okayama University
ＡＬＫ遺伝子変異陽性肺癌に対するＡＬＫ阻害薬と血管新生阻害薬の併用効果の検討Principal Investigator
- Principal Investigator
  
  市原英基
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse
- Principal Investigator
  
  KIURA Katsuyuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
A basic studyon malignant mesothelioma pathogenesis by internal radiation exposure of radium contained in the iron-containing protein
- Principal Investigator
  
  KIURA Katsuyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University

All 2023 2015 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] CDK4/6 signaling attenuates the effect of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer2023
- Author(s)
  Hara Naofumi、Ichihara Eiki、Kano Hirohisa、Ando Chihiro、Morita Ayako、Nishi Tatsuya、Okawa Sachi、Nakasuka Takamasa、Hirabae Atsuko、Abe Masaya、Asada Noboru、Ninomiya Kiichiro、Makimoto Go、Fujii Masanori、Kubo Toshio、Ohashi Kadoaki、Hotta Katsuyuki、Tabata Masahiro、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Translational Lung Cancer Research
  
  Volume: 12 Issue: 10 Pages: 2098-2112
- DOI
  10.21037/tlcr-23-99
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08179, KAKENHI-PROJECT-22K19529, KAKENHI-PROJECT-23K24339
[Journal Article] Src mediates ERK reactivation in gefitinib resistance in non-small cell lung cancer.2014
- Author(s)
  Ochi N, Takigawa N, Harada D, Yasugi M, Ichihara E, Hotta K, Tabata M, Tanimoto M, Kiura K.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 322 Issue: 1 Pages: 168-177
- DOI
  10.1016/j.yexcr.2014.01.007
- NAID
  120005517858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] A new human lung adenocarcinoma cell line harboring the EML4-ALK fusion gene.2014
- Author(s)
  Isozaki H, Yasugi M, Takigawa N, Hotta K, Ichihara E, Taniguchi A, Toyooka S, Hashida S, Sendo T, Tanimoto M, Kiura K.
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 2014 Issue: 10 Pages: 963-968
- DOI
  10.1093/jjco/hyu110
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] Everolimus prolonged survival in transgenic mice with EGFR-driven lung tumors.2014
- Author(s)
  Yasugi M, Takigawa N, Ochi N, Ohashi K, Harada D, Ninomiya T, Murakami T, Honda Y, Ichihara E, Tanimoto M, Kiura K.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 326 Issue: 2 Pages: 201-209
- DOI
  10.1016/j.yexcr.2014.04.012
- NAID
  120005526613
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] Subpopulation of small-cell lung cancer cells expressing CD133 and CD87 show resistance to chemotherapy.2013
- Author(s)
  Kubo T, Takigawa N, Osawa M, Harada D, Ninomiya T, Ochi N, Ichihara E, Yamane H, Tanimoto M, Kiura K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104 Issue: 1 Pages: 78-84
- DOI
  10.1111/cas.12045
- NAID
  120005311967
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.2013
- Author(s)
  Shien K, Toyooka S, Yamamoto H, Soh J, Jida M, Thu KL, Hashida S, Maki Y, Ichihara E, Asano H, Tsukuda K, Takigawa N, Kiura K, Gazdar AF, Lam WL, Miyoshi S.
- Journal Title
  
  Cancer Res.
  
  Volume: 73 Issue: 10 Pages: 3051-3061
- DOI
  10.1158/0008-5472.can-12-4136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-23592061
[Journal Article] Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in epidermal growth factor receptor-mutated lung cancer model.2013
- Author(s)
  Hayakawa H, Ichihara E, Ohashi K, Ninomiya T, Yasugi M, Takata S, Sakai K, Matsumoto K, Takigawa N, Tanimoto M, Kiura K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104 Issue: 11 Pages: 1440-1446
- DOI
  10.1111/cas.12284
- NAID
  120005468272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24300329
[Journal Article] Afatinib prolongs survival compared with gefitinib in an epidermal growth factor receptor-driven lung cancer model.2013
- Author(s)
  Ninomiya T, Takigawa N, Ichihara E, Ochi N, Murakami T, Honda Y, Kubo T, Minami D, Kudo K, Tanimoto M, Kiura K.
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: 12 Issue: 5 Pages: 589-597
- DOI
  10.1158/1535-7163.mct-12-0885
- NAID
  120005359109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency.2013
- Author(s)
  Takeda H, Takigawa N, Ohashi K, Minami D, Kataoka I, Ichihara E, Ochi N, Tanimoto M, Kiura K.
- Journal Title
  
  Mol Cancer Res
  
  Volume: 319 Issue: 2 Pages: 417-423
- DOI
  10.1158/1541-7786.mcr-12-0401
- NAID
  120005359097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-23651046, KAKENHI-PROJECT-24310042, KAKENHI-PLANNED-23114010
[Journal Article] Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency.2013
- Author(s)
  Takeda H, Takigawa N, Ohashi K, Minami D, Kataoka I, Ichihara E, Ochi N, Tanimoto M, Kiura K.
- Journal Title
  
  Exp Cell Res
  
  Volume: 319 Issue: 4 Pages: 417-427
- DOI
  10.1016/j.yexcr.2012.12.018
- NAID
  120005359097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] Impact of physical size on gefitinib efficacy in patients with non-small cell lung cancer harboring EGFR mutations.2013
- Author(s)
  Ichihara E, Hotta K, Takigawa N, Kudo K, Kato Y, Honda Y, Hayakawa H, Minami D, Sato A, Tabata M, Tanimoto M, Kiura K.
- Journal Title
  
  Lung Cancer.
  
  Volume: 81 Issue: 3 Pages: 435-439
- DOI
  10.1016/j.lungcan.2013.05.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] Antitumor Impact of p14ARF on Gefitinib-Resistant Non-Small Cell Lung Cancers.2013
- Author(s)
  Saito K, Takigawa N, Ohtani N, Iioka H, Tomita Y, Ueda R, Fukuoka J, Kuwahara K, Ichihara E, Kiura K, Kondo E.
- Journal Title
  
  Molecule Cancer Therapeutics
  
  Volume: 12 Issue: 8 Pages: 1616-1628
- DOI
  10.1158/1535-7163.mct-12-1239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300343, KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24590388, KAKENHI-PUBLICLY-25112716, KAKENHI-PROJECT-25290062, KAKENHI-PROJECT-25670263
[Journal Article] JAK2-related pathway induces acquired erlotinib resistance in lung cancer cells harboring an epidermal growth factor receptor-activating mutation2012
- Author(s)
  Harada D, Takigawa N, Ochi N, Ninomiya T, Yasugi M, Kubo T, Takeda H, Ichihara E, Ohashi K, Takata S, Tanimoto M, Kiura K
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Issue: 10 Pages: 1795-1802
- DOI
  10.1111/j.1349-7006.2012.02363.x
- NAID
  120005311974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182
[Journal Article] Liposomal delivery of microRNA-7-expressing plasmid overcomes epidermal growth factor receptor tyrosine kinase inhibitor-resistance in lung cancer cells2011
- Author(s)
  Rai K, Takigawa N, Ito S, Kashihara H, Ichihara E, Yasuda T, Shimizu K, Tanimoto M, Kiura K
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 10 Pages: 1720-1727
- NAID
  130004903196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] Establishment of pemetrexed-resistant non-small cell lung cancer cell lines2011
- Author(s)
  Zhang D, Ochi N, Takigawa N, Tanimoto I, Ichihara E, Hotta K, Tabata M, Tanimoto M, Kiura K
- Journal Title
  
  Cancer Lett
  
  Volume: 309 Issue: 2 Pages: 228-235
- DOI
  10.1016/j.canlet.2011.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] The impact of bevacizumab on combination low-dose afatinib and cetuximab therapy in lung cancer cells harboring activated EGFR mutations2015
- Author(s)
  Kenichiro Kudo, Sr., Kadoaki Ohashi, Eiki Ichihara, Daisuke Minami, Hisao Kubo, Akiko Sato, Yuka Kato, Hideko Isozaki, Hiroe Kayatani, Tomoki Tamura, Mitsune Tanimoto, Katsuyuki Kiura.
- Organizer
  The 106th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Philadelphia, PA, USA
- Year and Date
  2015-04-20
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] ALK inactivation induced acquired resistance to alectinib in lung cancer harboring EML4-ALK fusion gene.2014
- Author(s)
  Hideko Isozaki, Eiki Ichihara, Masayuki Yasugi, Ocihi Nobuaki, Katsuyuki Hotta, Nagio Takigawa, Toshiaki Sendo, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  The 105th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  San Diego, CA. USA
- Year and Date
  2014-04-08
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Afatinib prolonged survival in EGFR-driven lung cancer model compared to gefitinib2012
- Author(s)
  Takashi Ninomiya, Eiki Ichihara, Akiko Hisamoto, Katsuyuki Hotta, Mitsune Tanimoto, Katsuyuki Kiura, Nagio Takigawa, Nobuaki Ochi, Masayuki Yasugi, Daijiro Harada.
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  McCormick Place in Chicago, Illinois
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Effect of AZD1480 on lung tumor in transgenic mice carrying activating EGFR mutation2012
- Author(s)
  Toshi Murakami, Nagio Takigawa, Takashi Ninomiya, Nobuhiro Honda, Hideko Isozaki, Eiki Ichihara, Akiko Hisamoto, Katsuyuki Hotta, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  McCormick Place in Chicago, Illinois
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Role of ERK reactivation mediated by Src in acquired resistance to gefitinib in non-small cell lung cancer with EGFR mutation2011
- Author(s)
  Ochi N, Takigawa N, Ohashi K, Takeda H, Fujii M, Kubo T, Ichihara E, Hotta K, Tanimoto M, Kiura K
- Organizer
  AACR Annual Meeting 2011
- Place of Presentation
  Orange County Convention Center, Orlando, FL, USA
- Year and Date
  2011-04-03
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Vascular endothelial growth factor receptor tyrosine kinase inhibitor inhibited mutated epidermal growth factor receptor-driven tumors ex vivo and in vivo2011
- Author(s)
  Kubo T, Ohashi K, Osawa M, Takeda H, Ichihara E, Ninomiya T, Takigawa N, Harita S, Nakata Y, Tanimoto M, Kiura K
- Organizer
  AACR Annual Meeting 2011
- Place of Presentation
  Orange County Convention Center, Orlando, FL, USA
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Effect of afatinib on lung cancer burden induced by an exon 19 EGFR mutation in transgenic mice2011
- Author(s)
  Ninomiya T, Takigawa N, Kubo T, Yasugi M, Honda Y, Minami D, Murakami T, Ichihara E, Tanimoto M, Kiura K
- Organizer
  AACR Annual Meeting 2011
- Place of Presentation
  Orange County Convention Center, Orlando, FL, USA
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-23390221

1. TKIGAWA Nagio (60325107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
2. KIURA Katsuyuki (10243502)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
3. TAKATA Minoru (30281728)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. YOSHINO Tadashi (70183704)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. HOTTA Katsuyuki (70379816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. NAKABEPPU Yusaku (30180350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAMURA Eizo (80201672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 久保寿夫 (90726928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 藤田直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ichihara Eiki 市原 英基

ICHIHARA Eiki 市原 英基

Research Projects

Research Products

Co-Researchers

Development of lung cancer treatment targeting drug tolerance by SHP2.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ＡＬＫ遺伝子変異陽性肺癌に対するＡＬＫ阻害薬と血管新生阻害薬の併用効果の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A basic studyon malignant mesothelioma pathogenesis by internal radiation exposure of radium contained in the iron-containing protein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CDK4/6 signaling attenuates the effect of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Src mediates ERK reactivation in gefitinib resistance in non-small cell lung cancer.2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A new human lung adenocarcinoma cell line harboring the EML4-ALK fusion gene.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Everolimus prolonged survival in transgenic mice with EGFR-driven lung tumors.2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Subpopulation of small-cell lung cancer cells expressing CD133 and CD87 show resistance to chemotherapy.2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in epidermal growth factor receptor-mutated lung cancer model.2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Afatinib prolongs survival compared with gefitinib in an epidermal growth factor receptor-driven lung cancer model.2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency.2013

Author(s)

Journal Title

DOI

NAID

Data Source

Ichihara Eiki 市原英基

ICHIHARA Eiki 市原英基