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KURONUMA KOJI  黒沼 幸治

… Alternative Names

黒沼 幸治  クロヌマ コウジ

Kuronuma Koji  黒沼 幸治

KURONUMA Koji  黒沼 幸治

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Researcher Number 40563250
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-2743-3266
Affiliation (Current) 2020: 札幌医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2020: 札幌医科大学, 医学部, 准教授
2015 – 2018: 札幌医科大学, 医学部, 講師
2010 – 2013: 札幌医科大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related
Except Principal Investigator
Respiratory organ internal medicine
Keywords
Principal Investigator
非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / 間質性肺炎 / 肺サーファクタント / 非感染性肺障害 / ブレオマイシン肺障害モデル / ブレオマイシン / Toll様受容体 / 肺コレクチン … More / 肺炎球菌 / 感染症 / 肺炎球菌感染症 / 肺サーファクタント蛋白質 / マイクロバイオーム解析 … More
Except Principal Investigator
ブレオマイシン / 肺コレクチン / トル様受容体 / 薬剤性肺障害 / 肺サーファクタントタンパク質A / 肺サーファクタント / 肺傷害 / 肺サーファクタント蛋白質A / SP-A / TLR2 / ノックアウトマウス / 肺線維化 / 急性肺障害 / Toll-like receptor / 急性肺傷害 / アレルギー性気道炎症 / 抗炎症 / 抗線維化 / 間質性肺炎 / 内科 / 免疫学 Less
  • Research Projects

    (7 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (18 People)
  •  肺マイクロバイオーム多様性喪失と肺サーファクタント蛋白質の免疫機構Principal InvestigatorOngoing

    • Principal Investigator
      黒沼 幸治
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Sapporo Medical University
  •  TLR制御分子としての肺サーファクタントおよびHSP47抑制による肺線維化治療Ongoing

    • Principal Investigator
      高橋 弘毅
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Sapporo Medical University
  •  Pulmonary collectin regulates the severity of Streptococcus pneumoniae infectionPrincipal Investigator

    • Principal Investigator
      Kuronuma Koji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Sapporo Medical University
  •  Suppression of pulmonary injury and fibrosis by applying new action of pulmonary surfactant protein

    • Principal Investigator
      TAKAHASHI HIROKI
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Sapporo Medical University
  •  Therapeutic application of lung collectin in acute lung injury

    • Principal Investigator
      TAKAHASHI HIROKI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Sapporo Medical University
  •  Pulmonary surfactant protein A modulates non-infectious lung injury.Principal Investigator

    • Principal Investigator
      KURONUMA Koji
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Sapporo Medical University
  •  Pulmonary collectin regulates drug-induced lung injury.

    • Principal Investigator
      TAKAHASHI Hiroki
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Sapporo Medical University

All 2019 2018 2017 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

  • [Book] 初診時の対応. 特発性間質性肺炎の治療と管理2013

    • Author(s)
      黒沼幸治、高橋弘毅 (杉山幸比古編)
    • Publisher
      東京:克誠堂出版
    • Data Source
      KAKENHI-PROJECT-23591154
  • [Journal Article] Immunogenicity of pneumococcal vaccines in comorbid autoimmune and chronic respiratory diseases.2019

    • Author(s)
      Kuronuma K, Takahashi H.
    • Journal Title

      Hum Vaccin Immunother

      Volume: - Pages: 1-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09662
  • [Journal Article] Response to pneumococcal vaccine in interstitial lung disease patients: Influence of systemic immunosuppressive treatment.2018

    • Author(s)
      Kuronuma Koji、Honda Hiroyuki、Mikami Tessei、Saito Atsushi、Ikeda Kimiyuki、Otsuka Mitsuo、Chiba Hirofumi、Yamada Gen、Sato Toyotaka、Yokota Shin-ichi、Takahashi Hiroki
    • Journal Title

      Vaccine

      Volume: 36 Pages: 4968-4972

    • DOI

      10.1016/j.vaccine.2018.06.062

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662, KAKENHI-PROJECT-18K15956
  • [Journal Article] Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis.2018

    • Author(s)
      Takahashi Y, Saito A, Chiba H, Kuronuma K. Ikeda K. Kobayashi T, Ariki S, Takahashi M, Sasaki Y, Takahashi H.
    • Journal Title

      Respiratory Research

      Volume: 19 Pages: 34-34

    • DOI

      10.1186/s12931-018-0736-9

    • Description
      印刷中
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09181, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-17K07339, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-17K09662, KAKENHI-PROJECT-18K08150
  • [Journal Article] Poorer prognosis of idiopathic pleuroparenchymal fibroelastosis compared with idiopathic pulmonary fibrosis in advanced stage.2018

    • Author(s)
      Shioya Makoto、Otsuka Mitsuo、Yamada Gen、Umeda Yasuaki、Ikeda Kimiyuki、Nishikiori Hirotaka、Kuronuma Koji、Chiba Hirofumi、Takahashi Hiroki
    • Journal Title

      Can Respir J

      Volume: 2018 Pages: 6043053-6043053

    • DOI

      10.1155/2018/6043053

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662
  • [Journal Article] Whole genome analysis of a multidrug-resistant Streptococcus pneumoniae isolate from a patient with invasive pneumococcal infection developing disseminated intravascular coagulation2018

    • Author(s)
      Ohkoshi Yasuo、Sato Toyotaka、Wada Takayuki、Fukushima Yukari、Murabayashi Hiromi、Takakuwa Yasunari、Nishiyama Kaoru、Honda Hiroyuki、Shiraishi Tsukasa、Kuronuma Koji、Takahashi Hiroki、Nakajima Chie、Suzuki Yasuhiko、Yokota Shin-ichi
    • Journal Title

      J Infect Chemother

      Volume: 印刷中

    • DOI

      10.1016/j.jiac.2018.01.012

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09181
  • [Journal Article] Treatment of pulmonary fibrosis with siRNA against a collagen-specific chaperone HSP47 in vitamin A-coupled liposomes.2017

    • Author(s)
      Otsuka M, Shiratori M, Chiba H, Kuronuma K, Sato Y, Niitsu Y, Takahashi H.
    • Journal Title

      Experimental Lung Research

      Volume: 43 Pages: 271-282

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09662
  • [Journal Article] Surfactant protein A (SP-A) and SP-A-derived peptide attenuate chemotaxis of mast cells induced by human β-defensin 32017

    • Author(s)
      Uehara Y., Takahashi M., Murata M., Saito A., Takamiya R., Hasegawa Y., Kuronuma K., Chiba H., Hashimoto J., Sawada N., Takahashi H., Kuroki Y., Ariki S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 485 Pages: 107-112

    • DOI

      10.1016/j.bbrc.2017.02.028

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26440058, KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-16K19461, KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-17K07339, KAKENHI-PROJECT-15K09181, KAKENHI-PROJECT-16K19460
  • [Journal Article] Serum surfactant protein D predicts the outcome of patients with idiopathic pulmonary fibrosis treated with pirfenidone.2017

    • Author(s)
      Ikeda K, Shiratori M, Chiba H, Nishikiori H, Yokoo K, Saito A, Hasegawa Y, Kuronuma K, Otsuka M, Yamada G, Takahashi H.
    • Journal Title

      Respiratoru Medicine

      Volume: 131 Pages: 184-191

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09662
  • [Journal Article] Epidemiologic survey of Japanese patients with idiopathic pulmonary fibrosis and investigation of ethnic differences.2014

    • Author(s)
      Natsuizaka M, Chiba H, Kuronuma K, Otsuka M, Kudo K, Mori M, Bando M, Sugiyama Y, Takahashi H.
    • Journal Title

      Am J Respir Crit Care Med.

      Volume: 190 Pages: 773-779

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461164
  • [Journal Article] Distinct compartmentalization of SP-A and SP-D in the vasculature and lungs of patients with idiopathic pulmonary fibrosis.2014

    • Author(s)
      Nishikiori H, Chiba H, Ariki S, Kuronuma K, Otsuka M, Shiratori M, Ikeda K, Watanabe A, Kuroki Y, Takahashi H.
    • Journal Title

      BMC Pulm Med.

      Volume: 14 Pages: 196-196

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461164
  • [Journal Article] Pulmonary surfactant protein A protects lung epithelium from cytotoxicity of human β-defensin 3.2012

    • Author(s)
      Saito H, Kuronuma K, et.al.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790915
  • [Journal Article] Pulmonary surfactant protein A protectslung epithelium from cytotoxicity of humanβ-defensin 32012

    • Author(s)
      Saito A, Ariki S, Sohma H, Nishitani C, Inoue K, Ebata N, Takahashi M, Hasegawa Y, Kuronuma K, Takahashi H, Kuroki Y
    • Journal Title

      J Biol Chem

      Volume: 287(18) Pages: 15034-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790915
  • [Journal Article] Pulmonary surfactant protein A protects lung epithelium from cytotoxicity of human β-defensin 32012

    • Author(s)
      Saito A., et al
    • Journal Title

      J. Biol. Chem.

      Volume: (In press) Pages: 15034-15043

    • DOI

      10.1074/jbc.m111.308056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790764, KAKENHI-PROJECT-23591154, KAKENHI-PROJECT-24591686
  • [Journal Article] Anionic pulmonary surfactant phospholipids inhibit inflammatory responses from alveolar macrophages and U937 cells by binding the lipopolysaccharide-interacting proteins CD14 and MD-22009

    • Author(s)
      Kuronuma K, et al
    • Journal Title

      J Biol Chem 284

      Pages: 25488-25500

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590930
  • [Presentation] Pneumococcal vaccination in interstitial lung disease patients receiving systemic immunosuppressive treatment.2017

    • Author(s)
      Koji Kuronuma, Hiroyuki Honda, Tessei Mikami, Yuichiro Asai, Youhei Takahashi, Tomofumi Kobayashi, Atsushi Saito, Kimiyuki Ikeda, Hirotaka Nishikiori, Mamoru Takahashi, Mitsuo Otsuka, Hirofumi Chiba, Gen Yamada, Hiroki Takahashi, Toyotaka Sato
    • Organizer
      27th European Respiratory Society Annual Congress 2017.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09181
  • [Presentation] Retrospective analysis of microbiome in idiopathic pulmonary fibrosis.2017

    • Author(s)
      Youhei Takahashi, Astushi Saito, Kimiyuki Ikeda, Koji Kuronuma, Tomofumi Kobayashi, Yuichiro Asai, Hirotaka Nishikiori, Gen Yamada, Hirofumi Chiba, Yasushi Sasaki, Hiroki Takahashi, Mitsuo Otsuka, Mamoru Takahashi
    • Organizer
      27th European Respiratory Society Annual Congress 2017.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09181
  • [Presentation] 北海道における侵襲性細菌感染症サーベイランス構築の取組2015

    • Author(s)
      黒沼幸治
    • Organizer
      第112回日本内科学会講演会
    • Place of Presentation
      みやこめっせ(京都市左京区)
    • Year and Date
      2015-04-10
    • Data Source
      KAKENHI-PROJECT-15K09181
  • [Presentation] 北海道における侵襲性肺炎球菌感染症症例の検討2015

    • Author(s)
      黒沼幸治
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-04-17
    • Data Source
      KAKENHI-PROJECT-15K09181
  • [Presentation] 原発性肺腺癌におけるEGFR遺伝子変異とTTF-1、SP-A、SP-D発現の検討2015

    • Author(s)
      大塚満雄、梅田泰淳、成田欣史、黒沼幸治、山田玄、高橋弘毅
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2015-04-17
    • Data Source
      KAKENHI-PROJECT-26461164
  • [Presentation] HSP47siRNA targeting to myofibroblasts attenuates bleomycin-induced pulmonary fibrosis2013

    • Author(s)
      Otsuka M, Shiratori M, Kuronuma K,Takahashi H
    • Organizer
      22th European Respiratory Society Annual Congress
    • Place of Presentation
      Wien, Austria
    • Data Source
      KAKENHI-PROJECT-23591154
  • [Presentation] The decrease of surfactant protein D in bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia2013

    • Author(s)
      Nishikiori H, Chiba H, Otsuka M, Kuronuma K, Takahashi H
    • Organizer
      22th European Respiratory Society Annual Congress
    • Place of Presentation
      Wien,Austria
    • Data Source
      KAKENHI-PROJECT-23591154
  • [Presentation] ブレオマイシン誘導肺障害に対するSP-Aの自然免疫制御作用2012

    • Author(s)
      黒沼幸治、工藤和実、黒木由夫、高橋弘毅
    • Organizer
      日本呼吸器学会総会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23790915
  • [Presentation] The decrease of surfactant protein D in bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia.2012

    • Author(s)
      Nishikiori H, Chiba H, Otsuka M, Kuronuma K, Takahashi H
    • Organizer
      European Respiratory Society Annual Congress
    • Place of Presentation
      Vienna, Austria
    • Data Source
      KAKENHI-PROJECT-23790915
  • [Presentation] SP-AによるTLR2を介したブレオマイシン誘導肺障害の制御機構2011

    • Author(s)
      黒沼幸治、工藤和実、黒木由夫、高橋 弘毅
    • Organizer
      日本呼吸器学会総会
    • Data Source
      KAKENHI-PROJECT-23790915
  • [Presentation] SP-AによるTLR2を介したブレオマイシン誘導肺障害の制御機構2011

    • Author(s)
      黒沼幸治、高橋弘毅ら
    • Organizer
      日本肺サーファクタント界面医学会総会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-23591154
  • [Presentation] SP-AによるTLR2を介したブレオマイシン誘導肺障害の制御機構2011

    • Author(s)
      黒沼幸治、工藤和実、黒木由夫、高橋弘毅
    • Organizer
      日本肺サーファクタント界面医学会総会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-23790915
  • [Presentation] Surfactant protein A modulate bleomycininduced lung injury in toll-like receptor 2 dependent pathway.2010

    • Author(s)
      Kuronuma K, Kudo K, Kuroki Y, Takahashi H.
    • Organizer
      In : 20^<th> European Respiratory Society Annual Congress
    • Place of Presentation
      Barcelona, Spain
    • Data Source
      KAKENHI-PROJECT-20590930
  • [Presentation] Surfactant protein A modulate bleomycin-induced lung injury in toll-like receptor 2 dependent pathway2010

    • Author(s)
      Kuronuma K, Takahashi H, et al
    • Organizer
      European Respiratory Society
    • Place of Presentation
      スペイン バルセロナ
    • Year and Date
      2010-09-20
    • Data Source
      KAKENHI-PROJECT-20590930
  • [Presentation] Anionic surfactant phospholipids modulate Mycoplasma pneumoniae-induced inflammatory response from alveolar macrophages and U937 cells2009

    • Author(s)
      Kuronuma K
    • Organizer
      European Respiratory Society
    • Place of Presentation
      オーストリア ウィーン
    • Year and Date
      2009-09-16
    • Data Source
      KAKENHI-PROJECT-20590930
  • [Presentation] Anionic surfactant phospholipids modulate Mycoplasma pneumoniae-Induced inflammatory response from alveolar macrophages and U937 Cells.2009

    • Author(s)
      Kuronuma K, Chiba H, Takahshi H, Voelker D.
    • Organizer
      In : The 19^<th> European Respiratory Society Annual Congress
    • Place of Presentation
      Wien, Austria
    • Data Source
      KAKENHI-PROJECT-20590930
  • [Presentation] 特発性肺線維症における血清マーカーとピルフェニドンの治療効果との関連についての検討

    • Author(s)
      池田 貴美之, 白鳥 正典, 横尾 慶紀, 黒沼 幸治, 大塚 満雄, 千葉 弘文, 高橋 弘毅
    • Organizer
      第111回日本内科学会講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-11 – 2014-04-13
    • Data Source
      KAKENHI-PROJECT-26461164
  • [Presentation] EGFR遺伝子変異陽性肺腺癌におけるバイオマーカーとしての血清SP-A, SP-D, KL-6の有用性.

    • Author(s)
      梅田 泰淳, 大塚 満雄, 成田 欣史, 黒沼 幸治, 高橋 弘毅
    • Organizer
      第55回日本肺癌学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-11-14 – 2014-11-16
    • Data Source
      KAKENHI-PROJECT-26461164
  • [Presentation] 肺腺癌EGFR-TKI治療のバイオマーカーとしての血清SP-A、SP-D

    • Author(s)
      梅田 泰淳, 大塚 満雄, 成田 欣史, 黒沼 幸治, 高橋 弘毅
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-04-25 – 2014-04-27
    • Data Source
      KAKENHI-PROJECT-26461164
  • [Presentation] SP-AによるTLR2を介したブレオマイシン誘導肺障害の制御機構

    • Author(s)
      黒沼 幸治
    • Organizer
      日本肺サーファクタント・界面医学会第47回学術研究会
    • Place of Presentation
      徳島大学医学部青藍会館
    • Data Source
      KAKENHI-PROJECT-23790915
  • [Presentation] ブレオマイシン誘導肺障害に対するSP-Aの自然免疫制御作用

    • Author(s)
      黒沼幸治
    • Organizer
      日本呼吸器学会総会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-23790915
  • [Presentation] 特発性肺線維症におけるピルフェニドンの治療効果予測因子としての血清SP-D

    • Author(s)
      池田 貴美之, 白鳥 正典, 横尾 慶紀, 梅田 泰淳, 汐谷 心, 錦織 博貴, 黒沼 幸治, 大塚 満雄, 千葉 弘文, 高橋 弘毅
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-04-25 – 2014-04-27
    • Data Source
      KAKENHI-PROJECT-26461164
  • 1.  TAKAHASHI Hiroki (60231396)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 25 results
  • 2.  CHIBA Hirofumi (40347175)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 11 results
  • 3.  KUROKI Yoshio (70161784)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 4.  SHIRATORI Masanori (40295366)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 5.  KUDO Kazumi (90438002)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  SAITO ATSUSHI (00768939)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 7.  大塚 満雄 (10398323)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 8.  高橋 素子 (00303941)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 9.  HASEGAWA YOSHIHIRO (90643180)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  ARIKI Shigeru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  TAKAMIYA Rina
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  MURATA Masaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  ITOH Takehiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  和田 芳直
    # of Collaborated Projects: 0 results
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  • 15.  長谷川 喜弘
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  • 16.  沢田 典均
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  • 17.  佐々木 泰史
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  • 18.  相馬 仁
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