Hasegawa Yoshihiro 長谷川喜弘

… Alternative Names

HASEGAWA YOSHIHIRO 長谷川喜弘

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Researcher Number	90643180
Other IDs
Affiliation (Current)	2025: 札幌医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 札幌医科大学, 医学部, 講師 2014 – 2017: 札幌医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine / 0902:General internal medicine and related fields Except Principal Investigator Respiratory organ internal medicine / Basic Section 43030:Functional biochemistry-related
Keywords	Principal Investigator SP-D / 肺サーファクタント / EGFR / 肺胞マクロファージ / RANKL / 破骨細胞 / 肺がん / 肺サーファクタント蛋白質 / 肺気腫 / MMP … More / 肺炎 / ARDS / 呼吸器感染症 / シリカ / 肺線維症 / 珪肺 / じん肺 / 肺コレクチン / EGFR遺伝子変異 / 肺サーファクタントタンパク質 / レクチン / 糖鎖 / 変異型EGFR / 肺サーファクタント蛋白質D / SP-A … More Except Principal Investigator EGFR / 肺コレクチン / 肺サーファクタント / N-glycan / Glycosylation / 質量分析 / シグナル伝達 / 増殖因子受容体 / ErbB / ErbB4 / 糖鎖 / 肺傷害 / 抗線維化 / 抗炎症 / アレルギー性気道炎症 / トル様受容体 / 肺サーファクタントタンパク質A / ブレオマイシン / 急性肺傷害 / 肺腺がん / EGF / SP-D / 肺癌 / コレクチン / 肥満細胞 / 肺がん / アクロレイン / ディフェンシン / EGFシグナル Less

肺胞マクロファージに発現するEGFRの機能解析ーSP-Dとの相互作用の観点からーPrincipal Investigator
- Principal Investigator
  
  長谷川喜弘
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Sapporo Medical University
The mechanisms of functional regulation of ErbB4 by N-glycans.
- Principal Investigator
  
  Motoko Takahashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Sapporo Medical University
The mechanisms of RANKL-induced severe pneumoniaPrincipal Investigator
- Principal Investigator
  
  HASEGAWA YOSHIHIRO
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Sapporo Medical University
Pulmonary osteoclast-like cells as a novel therapeutic target in pulmonary fibrosisPrincipal Investigator
- Principal Investigator
  
  Hasegawa Yoshihiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Sapporo Medical University
Surfactant protein D inhibits activation of non-small cell lung cancer-associated mutant EGFRPrincipal Investigator
- Principal Investigator
  
  Hasegawa Yoshihiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
The mechanisms of EGF signaling suppression by pulmonary surfactant protein.Principal Investigator
- Principal Investigator
  
  Hasegawa Yoshihiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Suppression of pulmonary injury and fibrosis by applying new action of pulmonary surfactant protein
- Principal Investigator
  
  TAKAHASHI HIROKI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Studies of pulmonary surfactant proteins on new aspects of host defense functions: anti-tumor activity and defensive activity against disease development.
- Principal Investigator
  
  Kuroki Yoshio
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University

All 2024 2023 2022 2021 2020 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] N-glycan on N262 of FGFR3 regulates the intracellular localization and phosphorylation of the receptor.2024
- Author(s)
  Hashimoto, U., Fujitani, N., Uehara, Y., Okamoto, H., Saito, A., Ito, F., Ariki, S., Shiratsuchi, A., Hasegawa, Y., Takahashi, M.
- Journal Title
  
  Biochim. Biophys. Acta Gen. Subj.
  
  Volume: 1868 Issue: 4 Pages: 130565-130565
- DOI
  10.1016/j.bbagen.2024.130565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05698, KAKENHI-PROJECT-21K06083, KAKENHI-PROJECT-21K08207, KAKENHI-PROJECT-24K11372
[Journal Article] Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis.2024
- Author(s)
  Hasegawa Y, Franks JM, Tanaka Y, Uehara Y, Read DF, Williams C, Srivatsan S, Pitstick LB, Nikolaidis NM, Shaver CM, Kropski J, Ware LB, Taylor CJ, Banovich NE, Wu H, Gardner JC, Osterburg AR, Yu JJ, Kopras EJ, Teitelbaum SL, Wikenheiser-Brokamp KA, Trapnell C, McCormack FX.
- Journal Title
  
  Science Advances
  
  Volume: 10 Issue: 28
- DOI
  10.1126/sciadv.adl4913
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K11372
[Journal Article] Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis2023
- Author(s)
  Uehara Yasuaki, Tanaka Yusuke, Zhao Shuyang, et al.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1205-1205
- DOI
  10.1038/s41467-023-36810-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16144, KAKENHI-PROJECT-21K08207
[Journal Article] Site-specific analysis of N-glycans of receptor tyrosine kinases.2023
- Author(s)
  Takahashi M., Fujitani N., Uehara Y., Hasegawa Y.
- Journal Title
  
  Trends Glycosci. Glycotechnol.
  
  Volume: 35
- Data Source
  KAKENHI-PROJECT-21K06083
[Journal Article] Site-specific analysis of N-glycans of receptor tyrosine kinases2023
- Author(s)
  Takahashi Motoko, Fujitani Naoki, Uehara Yasuaki, Hasegawa Yoshihiro
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 35
- Data Source
  KAKENHI-PROJECT-21K06083
[Journal Article] Site-specific glycosylation analysis of epidermal growth factor receptor 2 (ErbB2): exploring structure and function toward therapeutic targeting2023
- Author(s)
  Fujitani Naoki、Uehara Yasuaki、Ariki Shigeru、Hashimoto Ukichiro、Mukai Jo、Hasegawa Yoshihiro、Takahashi Motoko
- Journal Title
  
  Glycobiology
  
  Volume: 34 Issue: 3 Pages: 130565-130565
- DOI
  10.1093/glycob/cwad100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06083, KAKENHI-PROJECT-21K08207, KAKENHI-PROJECT-24K11372
[Journal Article] Site-specific analysis of N-glycans of receptor tyrosine kinases.2023
- Author(s)
  Takahashi M., Fujitani N., Uehara Y., Hasegawa Y.
- Journal Title
  
  Trends in Glycoscience and Glycotechnology,
  
  Volume: 35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08207
[Journal Article] Role of glycosyltransferases in carcinogenesis; growth factor signaling and EMT/MET programs2022
- Author(s)
  Takahashi M, Hasegawa Y, Maeda K, Kitano M, Taniguchi N.
- Journal Title
  
  Glycoconjugate Journal
  
  Volume: 39 Issue: 2 Pages: 167-176
- DOI
  10.1007/s10719-022-10041-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22880, KAKENHI-PROJECT-21K08207, KAKENHI-PROJECT-21K06083
[Journal Article] N-glycosylation regulates MET processing and signaling2022
- Author(s)
  Atsushi Saitou, Yoshihiro Hasegawa, Naoki Fujitani, Shigeru Ariki, Yasuaki Uehara, Ukichiro Hashimoto, Atsushi Saito, Koji Kuronuma, Kunio Matsumoto, Hirofumi Chiba, Motoko Takahashi
- Journal Title
  
  Cancer Science
  
  Volume: ー Issue: 4 Pages: 1292-1304
- DOI
  10.1111/cas.15278
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17218, KAKENHI-PROJECT-20K22880, KAKENHI-PROJECT-19H03499, KAKENHI-PROJECT-20K08521, KAKENHI-PROJECT-20K08570, KAKENHI-PROJECT-21K08207, KAKENHI-PROJECT-21K18250, KAKENHI-PROJECT-21K06083
[Journal Article] Integrated Structual Analysis of N-glycans and Free Oligosaccharides Allows for a Quantitative Evalution of ER Stress2021
- Author(s)
  Fujitani N, Ariki S, Hasegawa Y, Uehara Y, Takahashi M.
- Journal Title
  
  Biochemistry
  
  Volume: 60 Issue: 21 Pages: 1708-1721
- DOI
  10.1021/acs.biochem.0c00969
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22880, KAKENHI-PROJECT-20K08521, KAKENHI-PROJECT-21K06083, KAKENHI-PROJECT-21K08207
[Journal Article] Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke2017
- Author(s)
  Takamiya Rina、Uchida Koji、Shibata Takahiro、Maeno Toshitaka、Kato Masaki、Yamaguchi Yoshiki、Ariki Shigeru、Hasegawa Yoshihiro、Saito Atsushi、Miwa Soichi、Takahashi Hiroki、Akaike Takaaki、Kuroki Yoshio、Takahashi Motoko
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 8304-8304
- DOI
  10.1038/s41598-017-08588-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-17K07339, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461, KAKENHI-PROJECT-16H04758
[Journal Article] Surfactant protein A inhibits growth and adherence of uropathogenic Escherichia coli to protect the bladder from infection.2017
- Author(s)
  Hashimoto J., Takahashi M., Satio A., Murata M., Kurimura Y., Nishitani C., Takamiya R., Uehara Y., Hasegawa Y., Hiyama Y., Sawada N., Takahashi S., Masumori N., Kuroki Y., Ariki S.
- Journal Title
  
  J. Immunol.
  
  Volume: 198 Issue: 7 Pages: 2898-2905
- DOI
  10.4049/jimmunol.1502626
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440058, KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461, KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-17K07339
[Journal Article] Surfactant protein A down-regulates epidermal growth factor receptor by mechanisms different from those of surfactant protein D2017
- Author(s)
  Yoshihiro Hasegawa, Motoko Takahashi, Shigeru Ariki, Atsushi Saito, Yasuaki Uehara, Rina Takamiya, Koji Kuronuma, Hirofumi Chiba, Yuji Sakuma, Hiroki Takahashi, Yoshio Kuroki
- Journal Title
  
  J Bill Chem
  
  Volume: 292 Issue: 45 Pages: 18565-18576
- DOI
  10.1074/jbc.m117.800771
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-17K07339, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461
[Journal Article] SP-Dによる変異型EGFR肺がんの制御機構2017
- Author(s)
  長谷川喜弘, 梅田泰淳, 大塚満雄, 有木茂, 高宮里奈, 齋藤充史, 黒沼幸治, 千葉弘文, 高橋弘毅, 黒木由夫, 高橋素子
- Journal Title
  
  分子呼吸器病
  
  Volume: 21 Pages: 80-83
- Data Source
  KAKENHI-PROJECT-16K19461
[Journal Article] Surfactant Protein A (SP-A) and SP-A-derived Peptide Attenuate Chemotaxis of Mast Cells Induced by Human β-defensin 3.2017
- Author(s)
  Uehara Y., Takahashi M., Murata M., Saito A., Takamiya R., Hasegawa Y., Kuronuma K., Chiba H., Hashimoto J., Sawada N., Takahashi H., Kuroki Y., Ariki S.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 485 Issue: 1 Pages: 107-112
- DOI
  10.1016/j.bbrc.2017.02.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440058, KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461, KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-17K07339, KAKENHI-PROJECT-15K09181
[Journal Article] Surfactant protein D inhibits activation of non-small cell lung cancer-associated mutant EGFR and affects clinical outcomes of patients2017
- Author(s)
  Umeda Y、Hasegawa Y、Otsuka M、Ariki S、Takamiya R、Saito A、Uehara Y、Saijo H、Kuronuma K、Chiba H、Ohnishi H、Sakuma Y、Takahashi H、Kuroki Y、Takahashi M
- Journal Title
  
  Oncogene
  
  Volume: 36 Issue: 46 Pages: 6432-6445
- DOI
  10.1038/onc.2017.253
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-17K07339, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461
[Journal Article] Serum surfactant protein D predicts the outcome of patients with idiopathic pulmonary fibrosis treated with pirfenidone2017
- Author(s)
  Ikeda Kimiyuki、Shiratori Masanori、Chiba Hirofumi、Nishikiori Hirotaka、Yokoo Keiki、Saito Atsushi、Hasegawa Yoshihiro、Kuronuma Koji、Otsuka Mitsuo、Yamada Gen、Takahashi Hiroki
- Journal Title
  
  Respir Med.
  
  Volume: 131 Pages: 184-191
- DOI
  10.1016/j.rmed.2017.08.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461
[Journal Article] SP-DによるEGFR制御機構2017
- Author(s)
  長谷川喜弘、高橋素子、高橋弘毅
- Journal Title
  
  BIO Clinica
  
  Volume: 14 Pages: 130-134
- Data Source
  KAKENHI-PROJECT-16K19461
[Journal Article] SP-A及びSP-A由来ペプチドはヒトβ-ディフェンシン3による肥満細胞の遊走を抑制する2016
- Author(s)
  (1)有木茂, 上原康昭, 村田雅樹, 高宮里奈, 長谷川喜弘, 齋藤充史, 千葉弘文, 黒沼幸治, 高橋素子, 高橋弘毅, 黒木由夫
- Journal Title
  
  分子呼吸器病
  
  Volume: 20 Pages: 123-123
- Data Source
  KAKENHI-PROJECT-26860611
[Journal Article] 肺サーファクタント蛋白質SP-Dの肺がんに対する新たな役割2016
- Author(s)
  長谷川喜弘、高橋素子、高橋弘毅
- Journal Title
  
  Medical Science Digest
  
  Volume: 42 Pages: 398-402
- Data Source
  KAKENHI-PROJECT-16K19461
[Journal Article] SP-AおよびSP-A由来ペプチドはヒトβ-ディフェンシン3による肥満細胞の遊走を抑制する2016
- Author(s)
  有木茂, 上原康昭, 村田雅樹, 高宮里奈, 長谷川喜弘, 齋藤充史, 千葉弘文, 黒沼幸治, 高橋素子, 高橋弘毅, 黒木由夫
- Journal Title
  
  分子呼吸器病
  
  Volume: 20 Pages: 120-123
- Data Source
  KAKENHI-PROJECT-25461194
[Journal Article] SP-A及びSP-A由来ペプチドはヒトβ-ディフェンシン3による肥満細胞の遊走を抑制する2016
- Author(s)
  有木茂, 上原康昭, 村田雅樹, 高宮里奈, 長谷川喜弘, 齋藤充史, 千葉弘文, 黒沼幸治, 高橋素子, 高橋弘毅, 黒木由夫
- Journal Title
  
  分子呼吸器病
  
  Volume: 20 Pages: 120-123
- Data Source
  KAKENHI-PROJECT-16K19461
[Journal Article] N-glycans of growth factor receptors: their role in receptor function and disease implications.2016
- Author(s)
  Takahashi M, Hasegawa Y, Gao C, Kuroki Y, Taniguchi N.
- Journal Title
  
  Clinical Science
  
  Volume: 130 Issue: 20 Pages: 1781-1792
- DOI
  10.1042/cs20160273
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-16K01849, KAKENHI-PROJECT-26440058, KAKENHI-PROJECT-16K19461
[Journal Article] 肺サーファクタント蛋白質のEGFシグナル制御を介した抗腫瘍作用2015
- Author(s)
  長谷川喜弘, 高橋素子, 有木茂, 高宮里奈, 上原康昭, 橋本次朗, 和田芳直, 高橋弘毅, 黒木由夫
- Journal Title
  
  分子呼吸器病
  
  Volume: 19 Pages: 107-111
- Data Source
  KAKENHI-PROJECT-25461194
[Journal Article] Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signaling.2015
- Author(s)
  Hasegawa Y, Takahashi M, Ariki S, Asakawa D, Tajiri M, Wada Y, Yamaguchi Y, Nishitani C, Takamiya R, Saito A, Uehara Y, Hashimoto J, Kurimura Y, Takahashi H, Kuroki Y
- Journal Title
  
  Oncogene
  
  Volume: 34 Pages: 838-845
- Data Source
  KAKENHI-PROJECT-26461164
[Journal Article] Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signaling2015
- Author(s)
  Hasegawa Y, Takahashi M, Ariki S, Asakawa D, Tajiri M, Wada Y, Yamaguchi Y, Nishitani C, Takamiya R, Saito A, Uehara Y, Hashimoto J, Kurimura Y, Takahashi H, Kuroki Y
- Journal Title
  
  Oncogene
  
  Volume: 34 Issue: 7 Pages: 838-845
- DOI
  10.1038/onc.2014.20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591154, KAKENHI-PROJECT-26860611, KAKENHI-PROJECT-25461194
[Journal Article] 肺サーファクタント蛋白質のEGFシグナル制御を介した抗腫瘍作用2015
- Author(s)
  長谷川喜弘, 高橋素子, 有木茂, 高宮里奈, 上原康昭, 橋本次郎, 和田芳直, 高橋弘毅, 黒木由夫
- Journal Title
  
  分子呼吸器病
  
  Volume: 19 Pages: 107-111
- Data Source
  KAKENHI-PROJECT-26860611
[Journal Article] 肺サーファクタントタンパク質SP-Dによる肺癌の進展の抑制2015
- Author(s)
  高橋素子, 長谷川喜弘, 黒木由夫
- Journal Title
  
  THE LUNG-perspectives
  
  Volume: 23 Pages: 65-69
- Data Source
  KAKENHI-PROJECT-26860611
[Journal Article] The Mechanisms of Epidermal Growth Factor Signaling Suppression by Pulmonary Surfactant Protein D2014
- Author(s)
  Hasegawa Y
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 26 Issue: 152 Pages: 159-165
- DOI
  10.4052/tigg.26.159
- NAID
  130004841394
- ISSN
  0915-7352, 1883-2113
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860611
[Journal Article] The single N-glycan deletion mutant of soluble ErbB3 protein attenuates heregulinβ1-induced tumor progression by blocking of the HIF-1 and Nrf2 pathway.2014
- Author(s)
  Takamiya R, Takahashi M, Uehara Y, Ariki S, Hashimoto J, Hasegawa Y, Kuroki Y
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 454 Issue: 3 Pages: 364-368
- DOI
  10.1016/j.bbrc.2014.10.086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591173, KAKENHI-PROJECT-25461194, KAKENHI-PROJECT-26440058, KAKENHI-PROJECT-26860611
[Journal Article] Suppression of heregulin beta signaling by single N-glycan deletion mutant of soluble ErbB32013
- Author(s)
  Takahashi M, Hasegawa Y, Ikeda Y, Wada Y, Tajiri M, Ariki S, Takamiya R, Nishitani C, Araki M, Yamaguchi Y, Taniguchi N, Kuroki Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Issue: 46 Pages: 32910-32921
- DOI
  10.1074/jbc.m113.491902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390081, KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24591173, KAKENHI-PROJECT-25430123, KAKENHI-PROJECT-25461194
[Presentation] アデノシンデアミナーゼ2(ADA2)のN結合型糖鎖の部位特異的な構造と機能の解明2024
- Author(s)
  藤谷直樹, 伊藤萌子, 有木茂, 長谷川喜弘, 伊藤史恵, 江川（岩城）祥子
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-24K11372
[Presentation] 珪肺モデルマウスにおけるRANKL依存性の肺線維症の発症機構2024
- Author(s)
  長谷川喜弘、田中悠祐, 上原康昭, 高橋素子, Francis X McCormack
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-24K11372
[Presentation] RANK C175R変異はERストレスを誘導し大理石病を引き起こす2023
- Author(s)
  上原康昭, 藤谷直樹, 長谷川喜弘, 有木茂, 橋本宇吉郎, 高橋素子
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K08207
[Presentation] 線維芽細胞増殖因子受容体FGFR1の糖鎖の構造と機能2023
- Author(s)
  高橋素子、岡本弘美、藤谷直樹、上原康昭、橋本宇吉郎、長谷川喜弘
- Organizer
  第4２回日本糖質学会
- Data Source
  KAKENHI-PROJECT-21K06083
[Presentation] FGFR1のN型糖鎖はレセプターの細胞内輸送と自己リン酸化を制御する2023
- Author(s)
  岡本弘美, 藤谷直樹, 上原康昭, 長谷川喜弘, 橋本宇吉郎, 有木茂, 白土明子, 高橋素子
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K08207
[Presentation] FGFR1のN型糖鎖はレセプターの細胞内輸送と自己リン酸化を制御する2023
- Author(s)
  岡本弘美、藤谷直樹、上原康昭、長谷川喜弘、橋本宇吉郎、有木茂、白土明子、高橋素子
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06083
[Presentation] ErbB2 (HER2) の分子安定性に関与するN-glycansの機能の評価2023
- Author(s)
  藤谷直樹, 上原康昭, 長谷川喜弘, 橋本宇吉郎, 有木茂, 高橋素子
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K08207
[Presentation] FGFR3のN型糖鎖は細胞膜への発現と活性を制御する2023
- Author(s)
  橋本宇吉郎, 藤谷直樹, 上原康昭, 長谷川喜弘, 有木茂, 高橋素子
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K08207
[Presentation] 線維芽細胞増殖因子受容体FGFR1の糖鎖の構造と機能2023
- Author(s)
  高橋素子, 岡本弘美, 藤谷直樹, 上原康昭, 橋本宇吉郎, 長谷川喜弘
- Organizer
  第42回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-21K08207
[Presentation] 肺サーファクタント蛋白質Dと受容体型チロシンキナーゼの糖鎖の相互作用2023
- Author(s)
  長谷川喜弘
- Organizer
  日本肺サーファクタント・界面医学会第59回学術研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K08207
[Presentation] ヒトErbB2(HER2)の部位特的糖鎖構造解析2022
- Author(s)
  藤谷直樹, 上原康昭, 長谷川喜弘, 橋本宇吉郎, 有木茂, 高橋素子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K08207
[Presentation] ヒトErbB2(HER2)の部位特異的糖鎖構造解析2022
- Author(s)
  藤谷直樹, 上原康昭, 長谷川喜弘, 橋本宇吉郎, 有木茂, 高橋素子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06083
[Presentation] ヒトRANKの糖鎖による機能制御メカニズムの解析2022
- Author(s)
  上原康昭, 藤谷直樹, 長谷川喜弘, 有木茂, 橋本宇吉郎, 岡本弘美, 高橋素子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06083
[Presentation] FGFR1の糖鎖の部位特異的構造解析と機能解析2022
- Author(s)
  岡本弘美, 藤谷直樹, 上原康昭, 長谷川喜弘, 橋本宇吉郎, 有木茂, 白土明子, 高橋素子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K08207
[Presentation] ヒトRANKの糖鎖による機能制御メカニズムの解析2022
- Author(s)
  上原康昭, 藤谷直樹, 長谷川喜弘, 有木茂, 橋本宇吉郎, 岡本弘美, 高橋素子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K08207
[Presentation] A Novel Pleurodesis Method Using Hydroxyapatite Microspheres2022
- Author(s)
  Yusuke Tanaka, Yoshihiro Hasegawa, Lori B. Pitstick, Huixing Wu, Elizabeth J. Kopras, Francis X. McCormack
- Organizer
  American Thoracic Society International Conference (ATS 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08207
[Presentation] 肝細胞増殖因子受容体METの糖鎖の構造と機能2022
- Author(s)
  高橋素子、齋藤淳、長谷川喜弘、藤谷直樹、有木茂、上原康昭、松本邦夫
- Organizer
  第41回日本糖質学会
- Data Source
  KAKENHI-PROJECT-21K06083
[Presentation] FGFR1の糖鎖の部位特異的構造解析と機能解析2022
- Author(s)
  岡本弘美、藤谷直樹、上原康昭、長谷川喜弘、橋本宇吉郎、有木茂、白土明子、○高橋素子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06083
[Presentation] 肺胞微石症における肺破骨細胞様細胞の機能解析2022
- Author(s)
  上原康昭, 長谷川喜弘, 高橋素子, McCormack Francis X.
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K08207
[Presentation] RANKL-dependent pulmonary fibrosis in the silicosis model mouse2021
- Author(s)
  Yoshihiro Hasegawa, Yasuaki Uehara, Yusuke Tanaka, Lori B. Pitstick, Huixing Wu, Elizabeth J. Kopras, Francis X. McCormack
- Organizer
  The 25th Congress of the Asian Pacific Society of Respirology (APSR 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08207
[Presentation] Upregulation of circulating RANKL induces osteoporosis in the silicosis model mouse2021
- Author(s)
  Yoshihiro Hasegawa, Yusuke Tanaka, Lori B. Pitstick, Huixing Wu, Elizabeth J. Kopras, Francis X. McCormack
- Organizer
  American Thoracic Society International Conference (ATS 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22880
[Presentation] RANKL-dependent pulmonary fibrosis in the silicosis model mouse2021
- Author(s)
  Yoshihiro Hasegawa, Yasuaki Uehara, Yusuke Tanaka, Lori B. Pitstick, Huixing Wu, Elizabeth J. Kopras, Francis X. McCormack
- Organizer
  The 25th Congress of the Asian Pacific Society of Respirology (APSR 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22880
[Presentation] Upregulation of circulating RANKL induces osteoporosis in the silicosis model mouse2021
- Author(s)
  Yoshihiro Hasegawa, Yusuke Tanaka, Ciara M. Shaver, Kevin K. Brown, Charles Perkins, Lori B. Pitstick, Christopher G. McKnight, Huixing Wu, Elizabeth J. Kopras, Francis X. McCormack
- Organizer
  American Thoracic Society International Conference (ATS 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08207
[Presentation] METの糖鎖による機能制御メカニズムの解析2021
- Author(s)
  齋藤淳、長谷川喜弘、藤谷直樹、有木茂、上原康昭、松本邦夫、高橋素子
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06083
[Presentation] The interaction of pulmonary collectins with N-glycans of epidermal growth factor receptor regulates lung adenocarcinoma progression2020
- Author(s)
  Yoshihiro Hasegawa
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K22880
[Presentation] RANKL Dependent Differentiation Of Pulmonary Osteoclast-like Cells In Silica-induced Pulmonary Fibrosis2020
- Author(s)
  Yoshihiro Hasegawa, Yusuke Tanaka, Ciara M. Shaver, Kevin K. Brown, Charles Perkins, Lori B. Pitstick, Christopher G. McKnight, Huixing Wu, Elizabeth J. Kopras, Francis X. McCormack
- Organizer
  American Thoracic Society International Conference (ATS 2020 Virtual)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22880
[Presentation] 肺サーファクタントタンパク質Dは変異型EGFRの活性化を阻害し、肺腺がんの進展を抑制する2017
- Author(s)
  長谷川喜弘、梅田泰淳、大塚満雄、有木茂、高宮里奈、齋藤充史、高橋弘毅、黒木由夫、高橋素子
- Organizer
  第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K19461
[Presentation] 肺サーファクタント蛋白質DによるEGFR遺伝子変異陽性肺がんの制御機構2016
- Author(s)
  長谷川喜弘, 高橋素子, 有木茂, 高宮里奈，齋藤充史, 高橋弘毅
- Organizer
  第114回北海道癌談話会例会
- Place of Presentation
  札幌医科大学（札幌市）
- Data Source
  KAKENHI-PROJECT-16K19461
[Presentation] SP-Dによる変異型EGFR肺がんの制御機構2016
- Author(s)
  長谷川喜弘, 梅田泰淳, 高橋素子, 大塚満雄, 有木茂, 高宮里奈，齋藤充史, 高橋弘毅, 黒木由夫
- Organizer
  第15回肺サーファクタント分子病態研究会
- Place of Presentation
  札幌医科大学（札幌市）
- Data Source
  KAKENHI-PROJECT-16K19461
[Presentation] 肺サーファクタント蛋白質Dによる変異型EGFRの制御機構2016
- Author(s)
  長谷川喜弘, 佐久間裕司, 高橋素子
- Organizer
  第75回日本癌学会学術総会, 2016年10月6日～8日
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K19461
[Presentation] 肺サーファクタント蛋白質AおよびDによるEGFRの機能制御メカニズム2015
- Author(s)
  長谷川喜弘, 高橋素子
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] 肺サーファクタント蛋白質AおよびDによるEGFRの機能制御メカニズム2015
- Author(s)
  長谷川喜弘, 高橋素子
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26860611
[Presentation] 肺コレクチンSP-Aによる肺胞マクロファージの分化調節機構の解明2015
- Author(s)
  高宮里奈, 有木茂,　村田雅樹,　長谷川喜弘,　高橋素子,　澤田典均,　黒木由夫
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] EGFRのドメインIIIの糖鎖による機能制御 Regulation of EGFR by site-specific glycosylation2015
- Author(s)
  高橋素子, 長谷川喜弘, 高宮里奈, 和田芳直, 田尻道子, 浅川大樹, 有木茂, 黒木由夫
- Organizer
  第３４回　日本糖質学会
- Place of Presentation
  東京大学安田講堂（東京都文京区）
- Year and Date
  2015-07-31
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] SP-AとSP-DによるEGFシグナル制御を介した抗腫瘍作用2015
- Author(s)
  長谷川喜弘, 高橋素子, 有木茂, 高宮里奈，上原康昭, 橋本次郎, 和田芳直, 高橋弘毅, 黒木由夫
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-26860611
[Presentation] 糖鎖改変・可溶型ErbB3による抗腫瘍作用の分子メカニズム2015
- Author(s)
  高橋素子, 加藤公児, 姚閔, 和田芳直, 田尻道子, 長谷川喜弘, 高宮里奈, 有木茂, 黒木由夫
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸市ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] 肺サーファクタントタンパク質SP-Dの機能2015
- Author(s)
  高橋素子, 長谷川喜弘, 高宮里奈, 有木茂, 高橋弘毅, 黒木由夫
- Organizer
  第３４回気道分泌研究会
- Place of Presentation
  札幌プリンスホテル国際館パミール（北海道札幌市）
- Year and Date
  2015-07-11
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] 肺サーファクタント蛋白質DによるEGFシグナル制御機構2014
- Author(s)
  長谷川喜弘
- Organizer
  第2回札幌呼吸器フロンティアセミナー
- Place of Presentation
  札幌
- Year and Date
  2014-07-03
- Data Source
  KAKENHI-PROJECT-26860611
[Presentation] 肺サーファクタント蛋白質のEGFシグナル制御を介した抗腫瘍作用2014
- Author(s)
  長谷川喜弘, 高橋素子, 有木茂, 高宮里奈, 上原康昭橋本次郎, 高橋弘毅, 黒木由夫
- Organizer
  第13回肺サーファクタント分子病態研究会
- Place of Presentation
  札幌
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-26860611
[Presentation] 可溶型ErbB3糖鎖欠損変異体とラパチニブのヘレグリンシグナル抑制作用における相乗効果2013
- Author(s)
  高橋素子、長谷川喜弘、有木茂、高宮里奈、和田芳直、田尻道子、黒木由夫
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] 肺コレクチンによるEGFシグナルの制御機構2013
- Author(s)
  長谷川喜弘, 高橋素子, 有木茂, 高宮里奈，上原康昭, 橋本次郎, 高橋弘毅, 黒木由夫
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] Surfactant proteins A and D suppress epidermal growth factor signaling through interactions with N-glycans of receptors.2013
- Author(s)
  Hasegawa Y, Takahashi M, Ariki S, Asakawa D, Tajiri M, Wada Y, Takamiya R, Uehara Y, Hashimoto J, Takahashi H, Kuroki Y.
- Organizer
  18th Congress of Asian Pacific Society of Respirology
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] Surfactant protein A-derived peptide protects lung epithelial cells from cytotoxix activity of human beta-defensin 3.2013
- Author(s)
  Uehara Y, Ariki S, Takahashi M, Takamiya R, Hasegawa Y, Takahashi H, Kuroki Y.
- Organizer
  18th Congress of Asian Pacific Society of Respirology
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] Surfactant proteins A and D suppress lung cancer progression by downregulation of EGF signaling
- Author(s)
  Hasegawa Y, Takahashi M, Ariki S, Takamiya R, Uehara Y, Hashimoto J, Takahashi H, Kuroki Y
- Organizer
  American Thoracic Society 2014 International Conference（ATS2014）
- Place of Presentation
  San Diego (USA)
- Year and Date
  2014-05-16 – 2014-05-21
- Data Source
  KAKENHI-PROJECT-26860611
[Presentation] Surfactant protein A-derived peptide decreases cytotoxicity of human β-defensin 3 without attenuationg antimicrobial activity.
- Author(s)
  Uehara Y, Ariki S, Saito A, Takahashi M, Hasegawa Y, Kuroki Y
- Organizer
  American Thoracic Society International Conference 2014
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-04-16 – 2014-04-21
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] Surfactant proteins A and D suppress lung cancer progression by downregulation of EGF signaling.
- Author(s)
  Hasegawa Y, Takahashi M, Ariki S, Uehara Y, Kuroki Y
- Organizer
  American Thoracic Society International Conference 2014
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-04-16 – 2014-04-21
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] 膀胱におけるサーファクタント蛋白質Aの発現と尿路病原性大腸菌に対する感染防御機構
- Author(s)
  橋本次朗、高橋聡、舛森直哉、有木茂、高宮里奈、高橋素子、黒木由夫、上原康昭、長谷川喜弘
- Organizer
  第６１回日本化学療法学会東日本支部総会
- Place of Presentation
  東京
- Year and Date
  2014-10-29 – 2014-10-31
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] 肺サーファクタント蛋白質AとDによるEGFシグナルの抑制作用
- Author(s)
  長谷川喜弘, 高橋素子, 有木茂, 高宮里奈, 上原康昭, 橋本次郎, 浅川大樹, 田尻道子, 和田芳直, 高橋弘毅, 黒木由夫
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26860611
[Presentation] Regulation of tumor microenvironment by tumor associated sialyl-tn antigen on integrin.
- Author(s)
  Takamiya R, Takahashi M, Ariki S, Hasegawa Y, Kuroki Y
- Organizer
  American Thoracic Society International Conference 2014
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-04-16 – 2014-04-21
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] 肺コレクチンの単球機能への影響
- Author(s)
  高宮里奈、村田雅樹、上原康昭、有木茂、長谷川喜弘、橋本次朗、高橋素子、澤田典均、黒木由夫
- Organizer
  第８７回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] 肺サーファクタント蛋白質AとDによるEGFシグナル制御作用
- Author(s)
  長谷川喜弘、高橋素子、有木茂、高宮里奈、上原康昭、橋本次朗、浅川大樹、田尻道子、和田芳直、高橋弘毅、黒木由夫
- Organizer
  第８７回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25461194
[Presentation] Surfactant protein A prevents UPEC adhesion to urothelial surface and inhibits growth of UPEC in urine.
- Author(s)
  Hashimoto J, Ariki S, Uehara Y, Hasegawa Y, Takamiya R, Hiyama Y, Kurimura Y, Takahashi S, Takahashi M, Masumori N, Kuroki Y.
- Organizer
  34th Congress of the Societe Internationale d’Urologie
- Place of Presentation
  Glasgaw, UK
- Year and Date
  2014-10-12 – 2014-10-15
- Data Source
  KAKENHI-PROJECT-25461194

1. MOTOKO TAKAHASHI (00303941)

# of Collaborated Projects: 5 results

# of Collaborated Products: 47 results
2. TAKAHASHI HIROKI (60231396)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
3. SAITO ATSUSHI (00768939)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 上原康昭 (40882907)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
5. Kuroki Yoshio (70161784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
6. ARIKI SHIGERU (80464478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
7. SAKUMA YUJI (10364514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 千葉弘文 (40347175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 大塚満雄 (10398323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 黒沼幸治 (40563250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 藤谷直樹 (10374191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
12. TAKAMIYA RINA

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
13. TAJIRI Michiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 和田芳直

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
15. 平山明子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 谷口直之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 齋藤淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hasegawa Yoshihiro 長谷川 喜弘

HASEGAWA YOSHIHIRO 長谷川 喜弘

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肺胞マクロファージに発現するEGFRの機能解析ーSP-Dとの相互作用の観点からーPrincipal Investigator

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The mechanisms of functional regulation of ErbB4 by N-glycans.

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The mechanisms of RANKL-induced severe pneumoniaPrincipal Investigator

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Pulmonary osteoclast-like cells as a novel therapeutic target in pulmonary fibrosisPrincipal Investigator

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Surfactant protein D inhibits activation of non-small cell lung cancer-associated mutant EGFRPrincipal Investigator

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The mechanisms of EGF signaling suppression by pulmonary surfactant protein.Principal Investigator

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Suppression of pulmonary injury and fibrosis by applying new action of pulmonary surfactant protein

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Studies of pulmonary surfactant proteins on new aspects of host defense functions: anti-tumor activity and defensive activity against disease development.

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[Journal Article] N-glycan on N262 of FGFR3 regulates the intracellular localization and phosphorylation of the receptor.2024

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[Journal Article] Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis.2024

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[Journal Article] Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis2023

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[Journal Article] Site-specific analysis of N-glycans of receptor tyrosine kinases.2023

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[Journal Article] Site-specific analysis of N-glycans of receptor tyrosine kinases2023

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[Journal Article] Site-specific glycosylation analysis of epidermal growth factor receptor 2 (ErbB2): exploring structure and function toward therapeutic targeting2023

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Hasegawa Yoshihiro 長谷川喜弘

HASEGAWA YOSHIHIRO 長谷川喜弘