Oda Tetsuro 小田哲郎

… Alternative Names

ODA Tetsuro 小田哲郎

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Researcher Number	40569290
Other IDs
Affiliation (Current)	2025: 山口大学, 医学部附属病院, 非常勤医師
Affiliation (based on the past Project Information) *help	2021 – 2024: 山口大学, 医学部附属病院, 講師 2023: 山口大学, 医学部, 特別医学研究員 2014 – 2021: 山口大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine
Keywords	Principal Investigator カルモジュリン / リアノジン受容体 / ダントロレン / カルシウムハンドリング / GRK5 / 心収縮力の保たれた心不全 / HFpEF / NFｋB / RyR2 / 動脈硬化 … More / 形質転換 / 小胞体ストレス / シグナル伝達 / 心肥大 / HDAC / 病的心肥大 / HDAC5 / アンレキサノクス / ドメイン連関障害 / 酸化ストレス / 分子心臓学 … More Except Principal Investigator カルモジュリン / リアノジン受容体 / 心不全 / 心肥大 / 不整脈 / 致死的不整脈 / 筋小胞体 / 小胞体Ca制御 / スキャホールド / 光干渉断層法 / 不安定プラーク / 心筋梗塞 / 小胞体ストレス / 拡張不全 / HFpEF / ERストレス / 心筋細胞 / Herpud1 / NFAT / herpud1 / calmodulin / ryanodine receptor / ダントロレン / EC coupling / E-C coupling / リアニジン受容体 / CPVT / Ca2+ハンドリング / Caハンドリング Less

Development of a new treatment method for HFpEF by correcting endoplasmic reticulum function
- Principal Investigator
  
  矢野雅文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
心筋梗塞ハイリスク病変に対する血管小胞体Ca制御による新規プラーク安定化療法の開発
- Principal Investigator
  
  岡村誉之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
リアノジン受容体の安定化に注目した左室収縮能の保たれた心不全に対する治療法の探査Principal Investigator
- Principal Investigator
  
  小田哲郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
A new treatment for heart failure and cardiac hypertrophy by controlling calmodulin translocation into the nucleus
- Principal Investigator
  
  Yamamoto Takeshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
Treatment of heart failure, cardiac hypertrophy, and fatal arrhythmia by ryanodine receptor-bound calmodulin regulation
- Principal Investigator
  
  YANO MASAFUMI
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
Exploration of treatments common to heart failure and atherosclerosis focusing on ryanodine receptor bound calmodulinPrincipal Investigator
- Principal Investigator
  
  Oda Tetsuro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
Novel treatment of arrhythmia and heart failure by controlling the domain of ryanodine receptors
- Principal Investigator
  
  Yamamoto Takeshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
Comprehensive treatment of heart failure, cardiac hypertrophy, and arrhythmia by controlling ryanodine receptor bound calmodulin
- Principal Investigator
  
  YANO Masafumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Explore the new heart failure therapy focus on calmodulin translocation in cardiac myocytesPrincipal Investigator
- Principal Investigator
  
  ODA Tetsuro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Novel therapy of arrhythmia targeting key domain in ryanodine receptor
- Principal Investigator
  
  YAMAMOTO Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Comprehensive strategy of heart failure, cardiac hypertrophy and lethal arrhythmia via stabilizing the stricture of ryanodine receptor
- Principal Investigator
  
  YANO Masafumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Oxidation of Ryanodine Receptor (RyR) and Calmodulin enhance Ca release and pathologically alter RyR structure and Calmodulin affinityPrincipal Investigator
- Principal Investigator
  
  ODA Tetsuro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure2023
- Author(s)
  Fujii Shohei、Kobayashi Shigeki、Chang Yaowei、Nawata Junya、Yoshitomi Ryosuke、Tanaka Shinji、Kohno Michiaki、Nakamura Yoshihide、Ishiguchi Hironori、Suetomi Takeshi、Uchinoumi Hitoshi、Oda Tetsuro、Okuda Shinichi、Okamura Takayuki、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 178 Pages: 36-50
- DOI
  10.1016/j.yjmcc.2023.03.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-22K15686
[Journal Article] Stabilizing cardiac ryanodine receptor with dantrolene treatment prevents left ventricular remodeling in pressure-overloaded heart failure mice2023
- Author(s)
  Yano Yasutake、Kobayashi Shigeki、Uchida Tomoyuki、Chang Yaowei、Nawata Junya、Fujii Shohei、Nakamura Yoshihide、Suetomi Takeshi、Uchinoumi Hitoshi、Oda Tetsuro、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 642 Pages: 175-184
- DOI
  10.1016/j.bbrc.2022.12.063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119
[Journal Article] Herpud1 modulates hypertrophic signals independently of calmodulin nuclear translocation in rat myocardium-derived H9C2 cells2023
- Author(s)
  Fujioka Riko、Yamamoto Takeshi、Maruta Akihiro、Nakamura Yoshihide、Tominaga Naoomi、Inamitsu Masako、Oda Tetsuro、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 652 Pages: 61-67
- DOI
  10.1016/j.bbrc.2023.02.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-21K08128
[Journal Article] Dantrolene improves left ventricular diastolic property in mineralcorticoid-salt-induced hypertensive rats2023
- Author(s)
  Nawata Junya、Yamamoto Takeshi、Tanaka Shinji、Yano Yasutake、Uchida Tomoyuki、Fujii Shohei、Nakamura Yoshihide、Suetomi Takeshi、Uchinoumi Hitoshi、Oda Tetsuro、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 34 Pages: 101449-101449
- DOI
  10.1016/j.bbrep.2023.101449
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119, KAKENHI-PROJECT-21K08128
[Journal Article] Dantrolene reduces platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice2022
- Author(s)
  Sakai Chihiro、Mikawa Mei、Yamamoto Takeshi、Uchida Tomoyuki、Nakamura Yoshihide、Akase Hideaki、Suetomi Takeshi、Tominaga Naoomi、Inamitsu Masako、Oda Tetsuro、Okamura Takayuki、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 623 Pages: 51-58
- DOI
  10.1016/j.bbrc.2022.07.038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20K17119
[Journal Article] Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.2022
- Author(s)
  Tanaka S, Yamamoto T, Mikawa M, Nawata J, Fujii S, Nakamura Y, Kato T, Fukuda M, Suetomi T, Uchinoumi H, Oda T, Okuda S, Okamura T, Kobayashi S, Yano M.
- Journal Title
  
  Heart Rhythm.
  
  Volume: S1547 Issue: 6 Pages: 00119-00119
- DOI
  10.1016/j.hrthm.2022.02.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-20K17119
[Journal Article] Herpud1 suppress angiotensin II induced hypertrophy in cardiomyocytes.2022
- Author(s)
  Mikawa M, Sakai C, Yamamoto T, Nakamura Y, Tanaka S, Tominaga N, Inamitsu M, Oda T, Kobayashi S, Yano M.
- Journal Title
  
  Biochem Biophys Rep.
  
  Volume: 30 Pages: 101248-101248
- DOI
  10.1016/j.bbrep.2022.101248
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128
[Journal Article] Endoplasmic reticulum stress promotes nuclear translocation of calmodulin, which activates phenotypic switching of vascular smooth muscle cells2022
- Author(s)
  Uchida Tomoyuki、Oda Tetsuro、Yamamoto Takeshi、Inamitsu Masako、Sakai Chihiro、Uchinoumi Hitoshi、Suetomi Takeshi、Nakamura Yoshihide、Okamoto Yoko、Tateda Satomi、Fujii Shohei、Tanaka Shinji、Nawata Junya、Okamura Takayuki、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 628 Pages: 155-162
- DOI
  10.1016/j.bbrc.2022.08.069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119
[Journal Article] Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca 2+ level and ER stress2020
- Author(s)
  Tamitani M, Yamamoto T, Yamamoto N, Fujisawa K, Tanaka S, Nakamura Y, Uchinoumi H, Oda T, Okuda S, Takami T, Kobayashi S, Sakaida I, Yano M.
- Journal Title
  
  Biochem Biophys Rep.
  
  Volume: 23:100787. Pages: 100787-100793
- DOI
  10.1016/j.bbrep.2020.100787
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08005, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20H03663
[Journal Article] G790del mutation in DSC2 alone is insufficient to develop the pathogenesis of ARVC in a mouse model2020
- Author(s)
  Hamada Yoriomi、Yamamoto Takeshi、Nakamura Yoshihide、Sufu-Shimizu Yoko、Nanno Takuma、Fukuda Masakazu、Ono Makoto、Oda Tesuro、Okuda Shinichi、Ueyama Takeshi、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 21 Pages: 100711-100711
- DOI
  10.1016/j.bbrep.2019.100711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-18K15890
[Journal Article] Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca2+/calmodulin-dependent protein kinase IIδc transgenic mice2020
- Author(s)
  Sufu-Shimizu Yoko、Okuda Shinichi、Kato Takayoshi、Nishimura Shigehiko、Uchinoumi Hitoshi、Oda Tetsuro、Kobayashi Shigeki、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 2 Pages: 431-438
- DOI
  10.1016/j.bbrc.2020.01.107
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-18K08039
[Journal Article] Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts2020
- Author(s)
  Kajii Toshiro、Kobayashi Shigeki、Shiba Sho、Fujii Shohei、Tamitani Masaki、Kohno Michiaki、Nakamura Yoshihide、Nanno Takuma、Kato Takayoshi、Okuda Shinichi、Uchinoumi Hitoshi、Oda Tetsuro、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 521 Issue: 1 Pages: 57-63
- DOI
  10.1016/j.bbrc.2019.10.071
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178
[Journal Article] Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling2020
- Author(s)
  Kohno Michiaki、Kobayashi Shigeki、Yamamoto Takeshi、Yoshitomi Ryosuke、Kajii Toshiro、Fujii Shohei、Nakamura Yoshihide、Kato Takayoshi、Uchinoumi Hitoshi、Oda Tetsuro、Okuda Shinichi、Watanabe Kenji、Mizukami Yoichi、Yano Masafumi
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 714-714
- DOI
  10.1038/s42003-020-01443-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11128, KAKENHI-PROJECT-18K16255, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-18K08572, KAKENHI-PROJECT-20H03677
[Journal Article] Ryanodine receptor-bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia2019
- Author(s)
  Nakamura Yoshihide、Yamamoto Takeshi、Kobayashi Shigeki、Tamitani Masaki、Hamada Yoriomi、Fukui Go、Xu Xiaojuan、Nishimura Shigehiko、Kato Takayoshi、Uchinoumi Hitoshi、Oda Tetsuro、Okuda Shinichi、Yano Masafumi
- Journal Title
  
  JCI Insight
  
  Volume: 4 Issue: 11 Pages: 1-18
- DOI
  10.1172/jci.insight.126112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178
[Journal Article] CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca 2+ release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy2018
- Author(s)
  Okuda Shinichi、Sufu-Shimizu Yoko、Kato Takayoshi、Fukuda Masakazu、Nishimura Shigehiko、Oda Tetsuro、Kobayashi Shigeki、Yamamoto Takeshi、Morimoto Sachio、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 496 Issue: 4 Pages: 1250-1256
- DOI
  10.1016/j.bbrc.2018.01.181
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08540, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-16K08514, KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-16K15443
[Journal Article] Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin2018
- Author(s)
  Oda Tetsuro、Yamamoto Takeshi、Kato Takayoshi、Uchinoumi Hitoshi、Fukui Go、Hamada Yoriomi、Nanno Takuma、Ishiguchi Hironori、Nakamura Yoshihide、Okamoto Yoko、Kono Michiaki、Okuda Shinichi、Kobayashi Shigeki、Bers Donald M.、Yano Masafumi
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 125 Pages: 87-97
- DOI
  10.1016/j.yjmcc.2018.10.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-16K09502, KAKENHI-PROJECT-17H04178
[Journal Article] Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.2018
- Author(s)
  Nishimura S, Yamamoto T, Nakamura Y, Kohno M, Hamada Y, Sufu Y, Fukui G, Nanno T, Ishiguchi H, Kato T, Xu X, Ono M, Oda T, Okuda S, Kobayashi S, Yano M.
- Journal Title
  
  Heart Rhythm
  
  Volume: 印刷中 Issue: 6 Pages: 905-914
- DOI
  10.1016/j.hrthm.2018.02.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-16K19409, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-16K15443
[Journal Article] Urinary 8-Hydroxy-2′-Deoxyguanosine as a Myocardial Oxidative Stress Marker Is Associated With Ventricular Tachycardia in Patients With Active Cardiac Sarcoidosis2017
- Author(s)
  Ishiguchi H, Kobayashi S, Myoren T, Kohno M, Nanno T, Murakami W, Oda S, Oishi K, Okuda S, Okada M, Suga K, Yano M.
- Journal Title
  
  Cardiovascular Imaging,
  
  Volume: 10 Issue: 12
- DOI
  10.1161/circimaging.117.006764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02110, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-16K15443
[Journal Article] Serial changes in the side-branch ostial area after main-vessel stenting with kissing balloon inflation for coronary bifurcation lesions, assessed by 3D optical coherence tomography.2017
- Author(s)
  Fujimura T, Okamura T, Tateishi H, Nakamura T, Yamada J, Oda T, Mochizuki M, Nishimura S, Nishimura T, Yano M.
- Journal Title
  
  Eur Heart J Cardiovasc Imaging
  
  Volume: - Issue: 10 Pages: 1-9
- DOI
  10.1093/ehjci/jex213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09504, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-16K15443
[Journal Article] Correction of impaired calmodulin binding to RyR2 as a novel therapy for lethal arrhythmia in the pressure-overloaded heart failure.2017
- Author(s)
  Kato T, Yamamoto T, Nakamura Y, Nanno T, Fukui G, Sufu Y, Hamada Y, Maeda T, Nishimura S, Ishiguchi H, Murakami W, Fukuda M, Xu X, Hino A, Ono M, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M.
- Journal Title
  
  Heart Rhythm
  
  Volume: 14 Issue: 1 Pages: 120-127
- DOI
  10.1016/j.hrthm.2016.10.019
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-16K15443, KAKENHI-PROJECT-16K19409, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-26293189
[Journal Article] An oxidative stress biomarker, urinary 8-hydroxy-2'-deoxyguanosine, predicts cardiovascular-related death after steroid therapy for patients with active cardiac sarcoidosis.2016
- Author(s)
  Myoren T, Kobayashi S, Oda S, Nanno T, Ishiguchi H, Murakami W, Okuda S, Okada M, Takemura G, Suga K, Matsuzaki M, Yano M.
- Journal Title
  
  Int J Cardiol
  
  Volume: 17 Pages: 206-213
- DOI
  10.1016/j.ijcard.2016.03.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670404, KAKENHI-PROJECT-26293189, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-16K09509, KAKENHI-PROJECT-26463081, KAKENHI-PROJECT-16K15443
[Journal Article] Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca2+ Leakage through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Isoproterenol in Failing Cardiomyocytes.2016
- Author(s)
  Murakami W, Kobayashi S, Susa T, Nanno T, Ishiguchi H, Myoren T, Nishimura S, Kato T, Hino A, Oda T, Okuda S, Yamamoto T, Yano M.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 9 Pages: e0163250-e0163250
- DOI
  10.1371/journal.pone.0163250
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-16K15443, KAKENHI-PROJECT-26293189
[Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine as a novel biomarker of inflammatory activity in patients with cardiac sarcoidosis2015
- Author(s)
  Kobayashi S, Myoren T, Oda S, Inari M, Ishiguchi H, Murakami W, Fukuda M, Tanaka T, Okuda S, Nao T, Doi M, Yamada J, Okamura T, Hoshii Y, Suga K, Matsuzaki M, Yano M.
- Journal Title
  
  Int J Cardiol.
  
  Volume: 190 Pages: 319-328
- DOI
  10.1016/j.ijcard.2015.04.144
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-26670404, KAKENHI-PROJECT-26293189
[Journal Article] Comparison of neointimal coverage and extra-stent lumen between sirolimus and everolimus-eluting stent using optical coherence tomography.2015
- Author(s)
  Oda T, Okamura T, Yamada J, Miyagi N, Uehara H, Nao T, Tateishi H, Maeda T, Nakamura T, Shiraishi K, Nakashima T, Nishimura S, Miura T, Matsuzaki M, Yano M
- Journal Title
  
  Heart Vessels
  
  Volume: 印刷中 Issue: 4 Pages: 449-456
- DOI
  10.1007/s00380-015-0630-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293189
[Journal Article] Oxidation of Ryanodine Receptor (RyR) and Calmodulin enhance Ca release and pathologically alter RyR structure and Calmodulin affinity2015
- Author(s)
  Tetsuro Oda, Yi Yang, Hitoshi Uchinoumi, David D. Thomas, Ye Chen-Izu, Takayoshi Kato, Takeshi Yamamoto, Masafumi Yano, Razvan L. Cornea, Donald M. Bers
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 85 Pages: 240-248
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670403
[Journal Article] A low-dose β1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulum.2015
- Author(s)
  Kobayashi S, Susa T, Ishiguchi H, Myoren T, Murakami W, Kato T, Fukuda M, Hino A, Suetomi T, Ono M, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Okuda S, Doi M, Yamamoto T, Yano M
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 1 Pages: e0114314-e0114314
- DOI
  10.1371/journal.pone.0114314
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293189, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-26670404
[Journal Article] Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.2015
- Author(s)
  Oda T, Yang Y, Uchinoumi H, Thomas DD, Chen-Izu Y, Kato T, Yamamoto T, Yano M, Cornea RL, Bers DM.
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 85 Pages: 240-248
- DOI
  10.1016/j.yjmcc.2015.06.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-26293189
[Journal Article] Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes2014
- Author(s)
  Fukuda M, Yamamoto T, Nishimura S, Kato T, Murakami W, Hino A, Ono M, Tateishi H, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 448(1) Issue: 1 Pages: 1-7
- DOI
  10.1016/j.bbrc.2014.03.152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-23591082, KAKENHI-PROJECT-23592256, KAKENHI-PROJECT-26293189, KAKENHI-PROJECT-26670404
[Presentation] Impaired Calmodulin binding affinity to Ryanodine receptor drives heart failure with preserved ejection fraction progression2023
- Author(s)
  内田　智之, 小田　哲郎
- Organizer
  第87回日本循環器学会総会
- Data Source
  KAKENHI-PROJECT-22K08156
[Presentation] リアノジン受容体安定化治療が心筋梗塞後の左室リモデリングや心室頻拍を抑制する2023
- Author(s)
  藤井翔平、小林茂樹、矢野泰健、内田智之、常　耀偉、縄田純也、中村吉秀、末冨　建、内海仁志、小田哲郎、岡村誉之、山本　健、矢野雅文
- Organizer
  第9回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-21K08054
[Presentation] 心筋型リアノジン受容体 4 量体構造の安定化は心筋梗塞後の予後を改善する2023
- Author(s)
  藤井翔平、小林茂樹、矢野泰健、内田智之、常　耀偉、中村吉秀、末冨　建、内海仁志、小田哲郎、岡村誉之、山本　健、矢野雅文
- Organizer
  第122回日本循環器学会中国四国合同地方会
- Data Source
  KAKENHI-PROJECT-21K08054
[Presentation] Restoring calmodulin binding affinity to ryanodine receptor type2 is protective in heart failure with preserved ejection fraction progression2022
- Author(s)
  内田　智之, 小田　哲郎
- Organizer
  2022 The 39th Annual Meeting of the Japanese Section
- Data Source
  KAKENHI-PROJECT-22K08156
[Presentation] Stabilization of RyR2 maintains right ventricular function, and improves prognosis in pulmonary hypertension2021
- Author(s)
  Shinji Tanaka，Takeshi Yamamoto，Jyunya Nawata，Shohei Fujii，Yoshihide Nakamura，Hitoshi Uchinoumi，Tetsuro Oda，Shigeki Kobayashi，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] Improving Ca2+ handling prevent doxorubicin induced cardiomyopathy in mice2021
- Author(s)
  Yoshihide Nakamura，Takeshi Yamamoto， Shinji Tanaka，Hitoshi Uchinoumi，Tetsuro Oda，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] Sterile inflammation through Ca2+/ Calmodulin-dependent protein kinase II (CaMKII) signaling is essential for adverse cardiac remodeling2021
- Author(s)
  Takeshi Suetomi，Shinichi Okuda，Satomi Tateda，Yoko Okamoto，Hitoshi Uchinoumi，Tetsuro Oda，Shigeki Kobayashi，Takeshi Yamamoto，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] Stabilization of RyR2 maintains right ventricular function, and improves prognosis in pulmonary hypertension2021
- Author(s)
  Shinji Tanaka, Takeshi Yamamoto, Junya Nawata, Shohei Fujii, Yoshihide Nakamura, Michiaki Kohno, Hitoshi Uchinoumi, Tetsuro Oda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-21K08054
[Presentation] Enhancing calmodulin binding affinity to ryanodine receptor type2 can be a therapeutic target for heart failure with preserved ejection fraction2021
- Author(s)
  Tomoyuki Uchida，Tetsuro Oda，Takeshi Suetomi，Takeshi Yamamoto，Shigeki Kobayashi，Yoshihide Nakamura，Shohei Fujii，Hitoshi Uchinoumi，Shinji Tanaka，Jyunya Nawata，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] RyR2-targeting therapy improves left ventricular remodeling after myocardial infarction2021
- Author(s)
  Shohei Fujii，Shigeki Kobayashi，Yaowei Chang，Jyunya Nawata，Shinji Tanaka，Yoshihide Nakamura，Takeshi Suetomi，Hitoshi Uchinoumi，Tetsuro Oda，Takeshi Yamamoto，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] Critical Role of Ryanodine Receptor Bound Calmodulin to Prevent Catecholaminergic Polymorphic Ventricular Tachycardia2019
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Shigeki Kobayashi, Masaki Tamitani, Yoriomi Hamada, Go Fukui, Xiaojuan Xu, Shigehiko Nishimura, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Masafumi Yano
- Organizer
  AHA BCVS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Stabilization of CaMKII-phosphorylated RyR2 By Dantrolene Prevents the Development of Age-related Cardiomyopathy in CaMKIIδc Transgenic Mice2019
- Author(s)
  Yoko Sufu-Shimizu, Shinichi Okuda, Yoko Okamoto, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08108
[Presentation] Critical Role of Ryanodine Receptor Bound Calmodulin to Prevent Catecholaminergic Polymorphic Ventricular Tachycardia2019
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Shigeki Kobayashi, Masaki Tamitani, Yoriomi Hamada, Go Fukui, Xiaojuan Xu, Shigehiko Nishimura, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Masafumi Yano
- Organizer
  AHA BCVS 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08108
[Presentation] Stabilization of CaMKII-phosphorylated RyR2 By Dantrolene Prevents the Development of Age-related Cardiomyopathy in CaMKIIδc Transgenic Mice2019
- Author(s)
  Yoko Sufu-Shimizu, Shinichi Okuda, Yoko Okamoto, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Stabilization of CaMKII-phosphorylated RyR2Prevents the Development of Age-related Car-diomyopathy Caused by Transgenic CaMKII δ cOverexpression2018
- Author(s)
  Yoko Sufu, Shinichi Okuda, Yoko Okamoto, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dissociation of calmodulin from cardiac ryanodine receptor plays a pivotal role in driving pathological cardiac hypertrophy2018
- Author(s)
  小田　哲郎
- Organizer
  第1回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-16K09502
[Presentation] Dissociation of calmodulin from cardiac ryanodine receptor plays a pivotal role in driving pathological cardiac hypertrophy2018
- Author(s)
  小田　哲郎
- Organizer
  Biophysical Society 62nd Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09502
[Presentation] Ryanodine Receptor Targeting Therapy InhibitsCardiomyocyte Hypertrophy and RelaxationImpairment in the Compensated Pressure-Overloaded Heart2018
- Author(s)
  Michiaki Kono, Shigeki Kobayashi, Toshiro Kajii, Takuma Nanno, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Stabilization of CaMKII-phosphorylated RyR2Prevents the Development of Age-related Car-diomyopathy Caused by Transgenic CaMKIIδc Overexpression2018
- Author(s)
  Yoko Sufu, Shinichi Okuda, Yoko Okamoto, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Dantrolene Prevents Right Ventricular Hypertro-phy without Reducing Pulmonary Arterial Pres-sure in Monocrotaline-Induced PAH in Mice2018
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Go Fukui, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Ryanodine Receptor Targeting Therapy InhibitsCardiomyocyte Hypertrophy and RelaxationImpairment in the Compensated Pressure- Overloaded Heart2018
- Author(s)
  Michiaki Kono, Shigeki Kobayashi, Toshiro Kajii, Takuma Nanno, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Dantrolene Prevents Right Ventricular Hypertro-phy without Reducing Pulmonary Arterial Pres-sure in Monocrotaline-Induced PAH in Mice2018
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Go Fukui, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Dantrolene Prevents Right Ventricular Hypertrophy Without Reducing Pulmonary Arterial Pressure In Monocrotaline-induced PAH In Mice2017
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Michiaki kono, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Hironori Ishiguchi, Shigehiko Nishimura, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Effect of Site Dependent RyR Stabilizers; a Clue to Trace a Signal Transmission Pathway Inside the RyR Molecule2017
- Author(s)
  Go Fukui, Takeshi Yamamoto, Michiaki Kono, Yoshihide Nakamura, Takuma Nanno, Yoriomi Hamada, Yoko Sufu, Hironori Ishiguchi, Shigehiko Nishimura, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Effect of Site Dependent RyR Stabilizers; a Clue to Trace a Signal Transmission Pathway Inside the RyR Molecule2017
- Author(s)
  Go Fukui, Takeshi Yamamoto, Michiaki Kono, Yoshihide Nakamura, Takuma Nanno, Yoriomi Hamada, Yoko Sufu, Hironori Ishiguchi, Shigehiko Nishimura, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Calmodulin, which dissociated from cardiac ryanodine receptor and translocation to the nucleus, plays a pivotal role in driving pathological cardiac hypertrophy2017
- Author(s)
  小田　哲郎
- Organizer
  第21回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09502
[Presentation] Stabilization of Camkii-Phosphorylated Ryr2 by Dantrolene Prevents the Development of Age-Related Cardiomyopathy Caused by CamkiiδC Overexpression2017
- Author(s)
  Yoko S Shimizu, Shinichi Okuda, Yoko Okamoto, Shigehiko Nishimura, Takayoshi Kato, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Stabilization of Camkii-Phosphorylated Ryr2 by Dantrolene Prevents the Development of Age-Related Cardiomyopathy Caused by CamkiiδC Overexpression2017
- Author(s)
  Yoko S Shimizu, Shinichi Okuda, Yoko Okamoto, Shigehiko Nishimura, Takayoshi Kato, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Dantrolene Prevents Right Ventricular Hypertrophy Without Reducing Pulmonary Arterial Pressure In Monocrotaline-induced PAH In Mice2017
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Michiaki kono, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Hironori Ishiguchi, Shigehiko Nishimura, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Correction of the Defective Channel Gating of Cardiac Ryanodine Receptor Improves Cardiac Function and Suppresses Ventricular Arrhythmia in Post Myocardial Infarction Heart Failure2016
- Author(s)
  Hironori Ishiguchi, Shigeki Kobayashi, Michiaki Kohno, Takuma Nanno, Gou Fukui, Yoko Sufu-Shimizu, Yoriomi Hamada, Takako Maeda, Shigehiko Nishimura, Tetsuro Oda, Shinnichi Okuda, Takeshi Ueyama, Takeshi Yamamoto and Masafumi Yano
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] Nuclear Translocation of Calmodulin, Which Dissociated From Cardiac Ryanodine Receptor, Promotes the Pathological Cardiac Hypertrophy2016
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Takayoshi Kato, Shigehiko Nishimura, Go Fukui, Shinichi Okuda, Shigeki Kobayashi, Donald Bers and Masafumi Yano
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] Correction Of Impaired Calmodulin Binding To Ryr2 As A Novel Therapy Of Lethal Arrhythmia In The Pressure-overloaded Heart Failure2016
- Author(s)
  Yoshihide Nakamura,Takeshi Yamamoto, Yamaguchi Univ Graduate Sch of Med, Une, Japan; Takayoshi Kato, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Shigehiko Nishimura, Hironori Ishiguchi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  89th Scientific Session of American Heart Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Nuclear translocation of calmodulin, which dissociated from cardiac ryanodine receptor (RyR2), promotes the pathological cardiac hypertrophy2016
- Author(s)
  小田　哲郎
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  Ernest N. Morial Convention Center, New Orleans, Louisiana, United States Of America
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09502
[Presentation] Nuclear translocation of both calmodulin, which bind to RyR2, and G protein-coupled receptor kinase 5 promote the pathological cardiac hypertrophy2016
- Author(s)
  小田　哲郎
- Organizer
  第20回日本心不全学会学術集会
- Place of Presentation
  ロイトン札幌・ホテルさっぽろ芸文館 (北海道　札幌市)
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-16K09502
[Presentation] Improvement of Defective Channel Function on RyR2 Mediated by CaMKII Activation Suppresses Arrhythmogenesis in TnT-related Hypertrophic Cardiomyopathy2016
- Author(s)
  Shinichi Okuda, Yoko Sufu-Shimizu, Takayoshi Kato, Yoko Okamoto, Shigehiko Nishimura, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto and Masafumi Yano
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] Correction of Impaired Calmodulin Binding to Ryr2 as a Novel Therapy of Lethal Arrhythmia in the Pressure-Overloaded Heart Failure2016
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Takayoshi Kato, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Shigehiko Nishimura, Hironori Ishiguchi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi and Masafumi Yano
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] High Affinity CaM, but Not Normal Affinity CaM Can Prevent Arrhythmias in CPVT Which Mutation Is Located at CaM-like Domain of RyR22015
- Author(s)
  Shigehiko Nishimura, Takeshi Yamamoto, Go Fukui, Takako Maeda, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dantrolene Cannot Inhibit Aberrant Ca2+ Release and Arrhythmias Without Calmodulin in Pressure Overload Heart Failure.2015
- Author(s)
  Go Fukui, Takeshi Yamamoto, Takayoshi Kato, Takako Maeda, Shigehiko Nishimura, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] High Affinity CaM, but Not Normal Affinity CaM Can Prevent Arrhythmias in CPVT Which Mutation Is Located at CaM-like Domain of RyR22015
- Author(s)
  Shigehiko Nishimura, Takeshi Yamamoto, Go Fukui, Takako Maeda, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] Dantrolene Enhances Binding of Calmodulin to RyR2 in CPVT Which Mutation Located at Central Domain but Does Not Enhance That in CPVT with Mutation at CaM-like Domain2015
- Author(s)
  Shigehiko Nishimura, Takeshi Yamamoto, Go Fukui, Takako Maeda, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] Dantrolene Enhances Binding of Calmodulin to RyR2 in CPVT Which Mutation Located at Central Domain but Does Not Enhance That in CPVT with Mutation at CaM-like Domain2015
- Author(s)
  Shigehiko Nishimura, Takeshi Yamamoto, Go Fukui, Takako Maeda, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dantrolene Cannot Inhibit Aberrant Ca2+ Release and Arrhythmias Without Calmodulin in Pressure Overload Heart Failure.2015
- Author(s)
  Go Fukui, Takeshi Yamamoto, Takayoshi Kato, Takako Maeda, Shigehiko Nishimura, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] In cardiomyocytes, dantrolene can correct defective domain interaction caused by oxidation, and restore calmodulin binding affinity in RyR2
- Author(s)
  小田　哲郎
- Organizer
  日本循環器学会
- Place of Presentation
  大阪 (大阪国際会議場）
- Year and Date
  2015-04-24 – 2015-04-26
- Data Source
  KAKENHI-PROJECT-26670403

1. YAMAMOTO Takeshi (50363122)

# of Collaborated Projects: 9 results

# of Collaborated Products: 45 results
2. 小林茂樹 (90397993)

# of Collaborated Projects: 6 results

# of Collaborated Products: 44 results
3. YANO Masafumi (90294628)

# of Collaborated Projects: 5 results

# of Collaborated Products: 33 results
4. 岡村誉之 (70380011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 南和幸 (00229759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 末冨建 (40749842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAMOTO Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. TANI Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. FUJISAWA Koichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. OKUDA Shinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. OKADA Munemasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 高見太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 森本幸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 水上洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oda Tetsuro 小田 哲郎

ODA Tetsuro 小田 哲郎

Research Projects

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Principal Investigator

Project Period (FY)

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Review Section

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Principal Investigator

Project Period (FY)

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リアノジン受容体の安定化に注目した左室収縮能の保たれた心不全に対する治療法の探査Principal Investigator

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Exploration of treatments common to heart failure and atherosclerosis focusing on ryanodine receptor bound calmodulinPrincipal Investigator

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Explore the new heart failure therapy focus on calmodulin translocation in cardiac myocytesPrincipal Investigator

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Oxidation of Ryanodine Receptor (RyR) and Calmodulin enhance Ca release and pathologically alter RyR structure and Calmodulin affinityPrincipal Investigator

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[Journal Article] RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure2023

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[Journal Article] Stabilizing cardiac ryanodine receptor with dantrolene treatment prevents left ventricular remodeling in pressure-overloaded heart failure mice2023

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[Journal Article] Herpud1 modulates hypertrophic signals independently of calmodulin nuclear translocation in rat myocardium-derived H9C2 cells2023

Oda Tetsuro 小田哲郎

ODA Tetsuro 小田哲郎