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Omata Yasunori  小俣 康徳

ORCIDConnect your ORCID iD *help
Researcher Number 40570734
Other IDs
Affiliation (Current) 2025: 東京大学, 医学部附属病院, 特任准教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 東京大学, 医学部附属病院, 特任准教授
2019 – 2021: 東京大学, 医学部附属病院, 特任講師
Review Section/Research Field
Principal Investigator
Basic Section 56020:Orthopedics-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Except Principal Investigator
Basic Section 56020:Orthopedics-related / Broad Section I / Basic Section 57060:Surgical dentistry-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords
Principal Investigator
変形性関節症 / 関節リウマチ / 自然免疫 / シングルセル解析 / 破骨細胞 / 細胞治療 / 自然免疫細胞 / 次世代シーケンサー
Except Principal Investigator
変形性関節症 / 関節炎 … More / 関節リウマチ / 免疫細胞 / マクロファージ / JAK-STAT pathway / 後根神経節 / 神経障害性疼痛 / 整形外科学 / 運動器恒常性維持 / シングルセル解析 / 骨粗鬆症 / 空間トランスクリプトーム解析 / 空間トランスクリプトーム / parabiosis / 循環マクロファージ / 組織常在性マクロファージ / 滑膜 / 関節滑膜組織 / 顎関節症 / 関節軟骨 / ルブリシン / 自然リンパ球 / 血友病 / 運動器 / 骨免疫 / 炎症性関節疾患 / Hhex / エピジェネティック制御 / ヒストン修飾 / エピジェネティクス / エピジェネティック修飾 / 破骨細胞 / JAK-STAT経路 / アロディニア / 慢性疼痛 / 関節炎モデル / 運動器学 / 統合運動器学 / ヒトゲノム解析 / 運動器科学 Less
  • Research Projects

    (14 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (26 People)
  •  血液凝固異常時の炎症に起因する関節症発症メカニズムの解明

    • Principal Investigator
      森 大典
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      The University of Tokyo
  •  関節滑膜の3型自然リンパ球による変形性関節症の制御機構の解明

    • Principal Investigator
      松本 卓巳
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      The University of Tokyo
  •  Establishment of novel cell therapies for joint diseases by activating innate immune systemPrincipal Investigator

    • Principal Investigator
      小俣 康徳
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      The University of Tokyo
  •  Establishment of an integrated locomotive science including spatiotemporal dynamics of bone-articular cells

    • Principal Investigator
      田中 栄
    • Project Period (FY)
      2023 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section I
    • Research Institution
      The University of Tokyo
  •  Elucidation of the mechanism of arthritis and establishment of therapeutic strategy by tissue-specific phenotypingPrincipal Investigator

    • Principal Investigator
      小俣 康徳
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      The University of Tokyo
  •  The mechanism of joint homeostasis in the coupling of articular cartilage and synovium

    • Principal Investigator
      矢野 文子
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Showa University
  •  滑膜の組織常在マクロファージと循環マクロファージが果たす役割

    • Principal Investigator
      三宅 崇文
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      The University of Tokyo
  •  後根神経節における神経・免疫連関から紐解く神経障害性疼痛の制御機構

    • Principal Investigator
      松林 嘉孝
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      The University of Tokyo
  •  Analysis of the mechanism of chronic pain in joint diseases using comprehensive expression analysis and single cell analysis.

    • Principal Investigator
      Taketomi Shuji
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      The University of Tokyo
  •  Transcription factor Hhex regulates bone homeostasis by negatively regulating osteoclast differentiation

    • Principal Investigator
      Matsumoto Takumi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      The University of Tokyo
  •  Identification of anti-inflammatory subsets of MSCs and their clinical application

    • Principal Investigator
      SAITO Taku
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      The University of Tokyo
  •  Osteoimmunology network between innate immunity and osteoclastPrincipal Investigator

    • Principal Investigator
      Omata Yasunori
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      The University of Tokyo
  •  Establishment of an integrated locomotive science including dynamics of bone-articular cells and regulation by immune system

    • Principal Investigator
      Tanaka Sakae
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section I
    • Research Institution
      The University of Tokyo
  •  次世代シングルセル解析技術を用いた破骨細胞分化の制御機構の解明Principal Investigator

    • Principal Investigator
      小俣 康徳
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      The University of Tokyo

All 2023 2022 2021

All Journal Article Presentation

  • [Journal Article] 骨粗鬆症の病態と治療2023

    • Author(s)
      小俣 康徳、田中 栄
    • Journal Title

      生体の科学

      Volume: 74 Pages: 560-564

    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Changes in knee joint destruction patterns among patients with rheumatoid arthritis undergoing total knee arthroplasty in recent decades2023

    • Author(s)
      Takeda Ryutaro、Matsumoto Takumi、Omata Yasunori、Inui Hiroshi、Taketomi Shuji、Nagase Yuichi、Nishikawa Takuji、Oka Hiroyuki、Tanaka Sakae
    • Journal Title

      Clinical Rheumatology

      Volume: 42 Issue: 9 Pages: 2341-2352

    • DOI

      10.1007/s10067-023-06620-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Associated correction of forefoot alignment with hindfoot fusion for pes planovalgus deformity2023

    • Author(s)
      Matsumoto Takumi、Takeda Ryutaro、Uchio Akihiro、Mizuhara Hiroyasu、Omata Yasunori、Juji Takuo、Tanaka Sakae
    • Journal Title

      Foot and Ankle Surgery

      Volume: 29 Issue: 3 Pages: 280-287

    • DOI

      10.1016/j.fas.2023.02.012

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Transcription Factor Hematopoietically Expressed Homeobox Protein (Hhex) Negatively Regulates Osteoclast Differentiation by Controlling Cyclin‐Dependent Kinase Inhibitors2022

    • Author(s)
      Watanabe Hisato、Okada Hiroyuki、Hirose Jun、Omata Yasunori、Matsumoto Takumi、Matsumoto Morio、Nakamura Masaya、Saito Taku、Miyamoto Takeshi、Tanaka Sakae
    • Journal Title

      JBMR Plus

      Volume: 6 Issue: 4

    • DOI

      10.1002/jbm4.10608

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08246, KAKENHI-PROJECT-20K22973, KAKENHI-PROJECT-21K16703, KAKENHI-PROJECT-21K09316, KAKENHI-PROJECT-21H03057
  • [Journal Article] Inflammatory Arthritis and Bone Metabolism Regulated by Type 2 Innate and Adaptive Immunity2022

    • Author(s)
      Omata Yasunori、Frech Michael、Saito Taku、Schett Georg、Zaiss Mario M.、Tanaka Sakae
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 3 Pages: 1104-1104

    • DOI

      10.3390/ijms23031104

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09568, KAKENHI-PROJECT-20K20473, KAKENHI-PROJECT-20K09495, KAKENHI-PROJECT-21K09316, KAKENHI-PROJECT-21K19552, KAKENHI-PROJECT-20H03799
  • [Journal Article] Outcomes of Scarf and Akin Osteotomy with Intra-Articular Stepwise Lateral Soft Tissue Release for Correcting Hallux Valgus Deformity in Rheumatoid Arthritis2021

    • Author(s)
      Matsumoto Takumi、Maenohara Yuji、Chang Song Ho、Ono Kumiko、Omata Yasunori、Hirose Jun、Tanaka Sakae
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 20 Pages: 10667-10667

    • DOI

      10.3390/ijerph182010667

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Comparison between suture and staple fixations as internal fixation techniques for Akin osteotomy2021

    • Author(s)
      Matsumoto Takumi、Takeda Ryutaro、Maenohara Yuji、Chang Song Ho、Omata Yasunori、Takuo Juji、Tanaka Sakae
    • Journal Title

      Foot and Ankle Surgery

      Volume: - Issue: 1 Pages: 100-106

    • DOI

      10.1016/j.fas.2021.02.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23599, KAKENHI-PROJECT-21K09316
  • [Journal Article] 【自然リンパ球と制御性T細胞の新知見】自然免疫innate lymphoid cell(ILC)による骨代謝・関節炎の制御機構2021

    • Author(s)
      小俣康徳、田中栄
    • Journal Title

      臨床免疫・アレルギー科

      Volume: - Pages: 267-273

    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Systemic inflammatory responses after orthopedic surgery in patients with rheumatoid arthritis treated with tofacitinib2021

    • Author(s)
      Uchio Akihiro、Matsumoto Takumi、Maenohara Yuji、Omata Yasunori、Takahashi Hiroshi、Iwasawa Mitsuyasu、Juji Takuo、Nakamura Ichiro、Tanaka Sakae
    • Journal Title

      Clinical Rheumatology

      Volume: 40 Issue: 12 Pages: 5077-5083

    • DOI

      10.1007/s10067-021-05914-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] TRPV2 is involved in induction of lubricin and suppression of ectopic endochondral ossification in articular joints2021

    • Author(s)
      Nakamoto Hideki、Katanosaka Yuki、Chijimatsu Ryota、Mori Daisuke、Xuan Fengjun、Yano Fumiko、Omata Yasunori、Maenohara Yuji、Murahashi Yasutaka、Kawaguchi Kohei、Yamagami Ryota、Inui Hiroshi、Taketomi Shuji、Taniguchi Yuki、Kanagawa Motoi、Naruse Keiji、Tanaka Sakae、Saito Taku
    • Journal Title

      Arthritis & Rheumatology

      Volume: - Issue: 8 Pages: 1441-1450

    • DOI

      10.1002/art.41684

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09568, KAKENHI-PROJECT-20K09428, KAKENHI-PROJECT-20K09451, KAKENHI-PROJECT-20K09452, KAKENHI-PROJECT-20K18053, KAKENHI-PROJECT-18K09055, KAKENHI-PROJECT-19K22677, KAKENHI-PROJECT-19K09641, KAKENHI-PROJECT-20K20473, KAKENHI-PROJECT-21H04960, KAKENHI-PROJECT-20H03799, KAKENHI-PROJECT-20K09405, KAKENHI-PROJECT-21K09294, KAKENHI-PROJECT-20K20644, KAKENHI-PROJECT-21K19552, KAKENHI-PROJECT-18K09019
  • [Journal Article] Symptomatic Medial Bone Excrescence in the Distal Phalanx of the Hallux after the First Metatarsophalangeal Joint Arthrodesis: A Case Report and Radiographic Reviews2021

    • Author(s)
      Maenohara Yuji、Takeda Ryutaro、Chang Song Ho、Omata Yasunori、Tanaka Sakae、Matsumoto Takumi
    • Journal Title

      Case Reports in Orthopedics

      Volume: 2021 Pages: 1-6

    • DOI

      10.1155/2021/6035784

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage2021

    • Author(s)
      Kaneko Taizo、Horiuchi Keisuke、Chijimatsu Ryota、Mori Daisuke、Nagata Kosei、Omata Yasunori、Yano Fumiko、Inui Hiroshi、Moro Toru、Tanaka Sakae、Saito Taku
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: 40 Issue: 2 Pages: 196-207

    • DOI

      10.1007/s00774-021-01278-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08246, KAKENHI-PROJECT-19K09568, KAKENHI-PROJECT-20K20473, KAKENHI-PROJECT-20H03799, KAKENHI-PROJECT-19K09641, KAKENHI-PROJECT-20K09405, KAKENHI-PROJECT-20K09452, KAKENHI-PROJECT-20K09495, KAKENHI-PROJECT-21K19552, KAKENHI-PROJECT-20K18053, KAKENHI-PROJECT-21K20942
  • [Presentation] Baricitinibは後根神経節細胞におけるIL-6 AmpとCSF-1の発現を抑制することによって関節炎モデルマウスの神経障害性疼痛を改善する.2023

    • Author(s)
      真壁健太, 小俣康徳, 岡田寛之, 千々松良太, 寺島明日香, 矢野文子, 田中栄, 齋藤琢.
    • Organizer
      第10回 JCRベーシックリサーチカンファレンス
    • Data Source
      KAKENHI-PROJECT-21K09294
  • [Presentation] メカニカルストレス応答性の関節滑膜の細胞変容と恒常性機構2023

    • Author(s)
      小俣 康徳
    • Organizer
      第8回日本骨免疫学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Presentation] ホメオボックスファミリー転写因子 Hhexは破骨細胞分化のネガティブレギュレーターである2021

    • Author(s)
      渡邉寿人、岡田寛之、小俣康徳、齋藤琢、宮本健史、田中栄
    • Organizer
      第6回日本骨免疫学会
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Presentation] 半拘束型人工肘関節Discoveryの使用成績2021

    • Author(s)
      小俣康徳、松本卓巳、田中栄
    • Organizer
      第50回日本リウマチの外科学会
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Presentation] 変形性膝関節症様の特徴をもつ関節リウマチ・膝関節症患者の増加~AIによる検証~2021

    • Author(s)
      武田龍太郎、松本卓巳、前之原悠司、小俣康徳、永瀬雄一、西川卓治、田中栄
    • Organizer
      第50回日本リウマチの外科学会
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Presentation] 抗コラーゲン抗体関節炎マウスを用いたBaricitinibの疼痛抑制作用の解析2021

    • Author(s)
      真壁健太、小俣康徳、淺香明子、柳原大、千々松良太、矢野文子、田中栄、齋藤琢
    • Organizer
      第36回日本整形外科学会基礎学術集会
    • Data Source
      KAKENHI-PROJECT-21K09294
  • [Presentation] KOACADシステムをも用いた生物学的製剤治療の有無による関節リウマチの膝関節単純X線画像的特徴についての検討2021

    • Author(s)
      小俣康徳、岡敬之、小泉泰彦、門野夕峰、大橋暁、安井哲郎、大野久美子、廣瀬旬、松本卓巳、田中栄
    • Organizer
      第65回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-21K09316
  • 1.  SAITO Taku (30456107)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 2.  Tanaka Sakae (50282661)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 11 results
  • 3.  Matsumoto Takumi (70436468)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 4.  寺島 明日香 (30596937)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  Taketomi Shuji (70570018)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  藤尾 圭志 (70401114)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  矢野 文子 (80529040)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  北條 宏徳 (80788422)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  石倉 久年 (80772904)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  橋爪 洋 (10326382)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  小松 紀子 (20553358)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  吉村 典子 (60240355)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  岡田 随象 (70727411)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  岡田 慶太 (50759173)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  乾 洋 (60583119)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  高柳 広 (20334229)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  鈴木 穣 (40323646)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  森 大典 (60835354)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  大野 久美子 (30444251)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  土屋 遥香 (50868560)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  小笠原 徹 (20359623)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  細沼 雅弘 (20836457)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  三宅 崇文 (10971997)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  松林 嘉孝 (50747962)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  加藤 壯 (50822061)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  田中 伸弥
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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