Omata Yasunori 小俣康徳

Researcher Number	40570734
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 特任准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 東京大学, 医学部附属病院, 特任准教授 2019 – 2021: 東京大学, 医学部附属病院, 特任講師
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields Except Principal Investigator Basic Section 56020:Orthopedics-related / Broad Section I / Basic Section 57060:Surgical dentistry-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator 変形性関節症 / 関節リウマチ / 自然免疫 / シングルセル解析 / 破骨細胞 / 細胞治療 / 自然免疫細胞 / 次世代シーケンサー Except Principal Investigator 変形性関節症 / 関節炎 … More / 関節リウマチ / 免疫細胞 / マクロファージ / JAK-STAT pathway / 後根神経節 / 神経障害性疼痛 / 整形外科学 / 運動器恒常性維持 / シングルセル解析 / 骨粗鬆症 / 空間トランスクリプトーム解析 / 空間トランスクリプトーム / parabiosis / 循環マクロファージ / 組織常在性マクロファージ / 滑膜 / 関節滑膜組織 / 顎関節症 / 関節軟骨 / ルブリシン / 自然リンパ球 / 血友病 / 運動器 / 骨免疫 / 炎症性関節疾患 / Hhex / エピジェネティック制御 / ヒストン修飾 / エピジェネティクス / エピジェネティック修飾 / 破骨細胞 / JAK-STAT経路 / アロディニア / 慢性疼痛 / 関節炎モデル / 運動器学 / 統合運動器学 / ヒトゲノム解析 / 運動器科学 Less

血液凝固異常時の炎症に起因する関節症発症メカニズムの解明
- Principal Investigator
  
  森大典
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
関節滑膜の３型自然リンパ球による変形性関節症の制御機構の解明
- Principal Investigator
  
  松本卓巳
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Establishment of novel cell therapies for joint diseases by activating innate immune systemPrincipal Investigator
- Principal Investigator
  
  小俣康徳
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
Establishment of an integrated locomotive science including spatiotemporal dynamics of bone-articular cells
- Principal Investigator
  
  田中栄
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  The University of Tokyo
Elucidation of the mechanism of arthritis and establishment of therapeutic strategy by tissue-specific phenotypingPrincipal Investigator
- Principal Investigator
  
  小俣康徳
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
The mechanism of joint homeostasis in the coupling of articular cartilage and synovium
- Principal Investigator
  
  矢野文子
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Showa University
滑膜の組織常在マクロファージと循環マクロファージが果たす役割
- Principal Investigator
  
  三宅崇文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
後根神経節における神経・免疫連関から紐解く神経障害性疼痛の制御機構
- Principal Investigator
  
  松林嘉孝
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Analysis of the mechanism of chronic pain in joint diseases using comprehensive expression analysis and single cell analysis.
- Principal Investigator
  
  Taketomi Shuji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Transcription factor Hhex regulates bone homeostasis by negatively regulating osteoclast differentiation
- Principal Investigator
  
  Matsumoto Takumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Identification of anti-inflammatory subsets of MSCs and their clinical application
- Principal Investigator
  
  SAITO Taku
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
Osteoimmunology network between innate immunity and osteoclastPrincipal Investigator
- Principal Investigator
  
  Omata Yasunori
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Establishment of an integrated locomotive science including dynamics of bone-articular cells and regulation by immune system
- Principal Investigator
  
  Tanaka Sakae
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  The University of Tokyo
次世代シングルセル解析技術を用いた破骨細胞分化の制御機構の解明Principal Investigator
- Principal Investigator
  
  小俣康徳
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] 骨粗鬆症の病態と治療2023
- Author(s)
  小俣　康徳、田中　栄
- Journal Title
  
  生体の科学
  
  Volume: 74 Pages: 560-564
- Data Source
  KAKENHI-PROJECT-21K09316
[Journal Article] Changes in knee joint destruction patterns among patients with rheumatoid arthritis undergoing total knee arthroplasty in recent decades2023
- Author(s)
  Takeda Ryutaro、Matsumoto Takumi、Omata Yasunori、Inui Hiroshi、Taketomi Shuji、Nagase Yuichi、Nishikawa Takuji、Oka Hiroyuki、Tanaka Sakae
- Journal Title
  
  Clinical Rheumatology
  
  Volume: 42 Issue: 9 Pages: 2341-2352
- DOI
  10.1007/s10067-023-06620-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09316
[Journal Article] Associated correction of forefoot alignment with hindfoot fusion for pes planovalgus deformity2023
- Author(s)
  Matsumoto Takumi、Takeda Ryutaro、Uchio Akihiro、Mizuhara Hiroyasu、Omata Yasunori、Juji Takuo、Tanaka Sakae
- Journal Title
  
  Foot and Ankle Surgery
  
  Volume: 29 Issue: 3 Pages: 280-287
- DOI
  10.1016/j.fas.2023.02.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09316
[Journal Article] Transcription Factor Hematopoietically Expressed Homeobox Protein (Hhex) Negatively Regulates Osteoclast Differentiation by Controlling Cyclin‐Dependent Kinase Inhibitors2022
- Author(s)
  Watanabe Hisato、Okada Hiroyuki、Hirose Jun、Omata Yasunori、Matsumoto Takumi、Matsumoto Morio、Nakamura Masaya、Saito Taku、Miyamoto Takeshi、Tanaka Sakae
- Journal Title
  
  JBMR Plus
  
  Volume: 6 Issue: 4
- DOI
  10.1002/jbm4.10608
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08246, KAKENHI-PROJECT-20K22973, KAKENHI-PROJECT-21K16703, KAKENHI-PROJECT-21K09316, KAKENHI-PROJECT-21H03057
[Journal Article] Inflammatory Arthritis and Bone Metabolism Regulated by Type 2 Innate and Adaptive Immunity2022
- Author(s)
  Omata Yasunori、Frech Michael、Saito Taku、Schett Georg、Zaiss Mario M.、Tanaka Sakae
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 3 Pages: 1104-1104
- DOI
  10.3390/ijms23031104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09568, KAKENHI-PROJECT-20K20473, KAKENHI-PROJECT-20K09495, KAKENHI-PROJECT-21K09316, KAKENHI-PROJECT-21K19552, KAKENHI-PROJECT-20H03799
[Journal Article] Outcomes of Scarf and Akin Osteotomy with Intra-Articular Stepwise Lateral Soft Tissue Release for Correcting Hallux Valgus Deformity in Rheumatoid Arthritis2021
- Author(s)
  Matsumoto Takumi、Maenohara Yuji、Chang Song Ho、Ono Kumiko、Omata Yasunori、Hirose Jun、Tanaka Sakae
- Journal Title
  
  International Journal of Environmental Research and Public Health
  
  Volume: 18 Issue: 20 Pages: 10667-10667
- DOI
  10.3390/ijerph182010667
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09316
[Journal Article] Comparison between suture and staple fixations as internal fixation techniques for Akin osteotomy2021
- Author(s)
  Matsumoto Takumi、Takeda Ryutaro、Maenohara Yuji、Chang Song Ho、Omata Yasunori、Takuo Juji、Tanaka Sakae
- Journal Title
  
  Foot and Ankle Surgery
  
  Volume: - Issue: 1 Pages: 100-106
- DOI
  10.1016/j.fas.2021.02.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23599, KAKENHI-PROJECT-21K09316
[Journal Article] 【自然リンパ球と制御性T細胞の新知見】自然免疫innate lymphoid cell(ILC)による骨代謝・関節炎の制御機構2021
- Author(s)
  小俣康徳、田中栄
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: - Pages: 267-273
- Data Source
  KAKENHI-PROJECT-21K09316
[Journal Article] Systemic inflammatory responses after orthopedic surgery in patients with rheumatoid arthritis treated with tofacitinib2021
- Author(s)
  Uchio Akihiro、Matsumoto Takumi、Maenohara Yuji、Omata Yasunori、Takahashi Hiroshi、Iwasawa Mitsuyasu、Juji Takuo、Nakamura Ichiro、Tanaka Sakae
- Journal Title
  
  Clinical Rheumatology
  
  Volume: 40 Issue: 12 Pages: 5077-5083
- DOI
  10.1007/s10067-021-05914-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09316
[Journal Article] TRPV2 is involved in induction of lubricin and suppression of ectopic endochondral ossification in articular joints2021
- Author(s)
  Nakamoto Hideki、Katanosaka Yuki、Chijimatsu Ryota、Mori Daisuke、Xuan Fengjun、Yano Fumiko、Omata Yasunori、Maenohara Yuji、Murahashi Yasutaka、Kawaguchi Kohei、Yamagami Ryota、Inui Hiroshi、Taketomi Shuji、Taniguchi Yuki、Kanagawa Motoi、Naruse Keiji、Tanaka Sakae、Saito Taku
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: - Issue: 8 Pages: 1441-1450
- DOI
  10.1002/art.41684
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09568, KAKENHI-PROJECT-20K09428, KAKENHI-PROJECT-20K09451, KAKENHI-PROJECT-20K09452, KAKENHI-PROJECT-20K18053, KAKENHI-PROJECT-18K09055, KAKENHI-PROJECT-19K22677, KAKENHI-PROJECT-19K09641, KAKENHI-PROJECT-20K20473, KAKENHI-PROJECT-21H04960, KAKENHI-PROJECT-20H03799, KAKENHI-PROJECT-20K09405, KAKENHI-PROJECT-21K09294, KAKENHI-PROJECT-20K20644, KAKENHI-PROJECT-21K19552, KAKENHI-PROJECT-18K09019
[Journal Article] Symptomatic Medial Bone Excrescence in the Distal Phalanx of the Hallux after the First Metatarsophalangeal Joint Arthrodesis: A Case Report and Radiographic Reviews2021
- Author(s)
  Maenohara Yuji、Takeda Ryutaro、Chang Song Ho、Omata Yasunori、Tanaka Sakae、Matsumoto Takumi
- Journal Title
  
  Case Reports in Orthopedics
  
  Volume: 2021 Pages: 1-6
- DOI
  10.1155/2021/6035784
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09316
[Journal Article] Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage2021
- Author(s)
  Kaneko Taizo、Horiuchi Keisuke、Chijimatsu Ryota、Mori Daisuke、Nagata Kosei、Omata Yasunori、Yano Fumiko、Inui Hiroshi、Moro Toru、Tanaka Sakae、Saito Taku
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: 40 Issue: 2 Pages: 196-207
- DOI
  10.1007/s00774-021-01278-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08246, KAKENHI-PROJECT-19K09568, KAKENHI-PROJECT-20K20473, KAKENHI-PROJECT-20H03799, KAKENHI-PROJECT-19K09641, KAKENHI-PROJECT-20K09405, KAKENHI-PROJECT-20K09452, KAKENHI-PROJECT-20K09495, KAKENHI-PROJECT-21K19552, KAKENHI-PROJECT-20K18053, KAKENHI-PROJECT-21K20942
[Presentation] Baricitinibは後根神経節細胞におけるIL-6 AmpとCSF-1の発現を抑制することによって関節炎モデルマウスの神経障害性疼痛を改善する.2023
- Author(s)
  真壁健太, 小俣康徳, 岡田寛之, 千々松良太, 寺島明日香, 矢野文子, 田中栄, 齋藤琢.
- Organizer
  第10回 JCRベーシックリサーチカンファレンス
- Data Source
  KAKENHI-PROJECT-21K09294
[Presentation] メカニカルストレス応答性の関節滑膜の細胞変容と恒常性機構2023
- Author(s)
  小俣　康徳
- Organizer
  第8回日本骨免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09316
[Presentation] ホメオボックスファミリー転写因子 Hhexは破骨細胞分化のネガティブレギュレーターである2021
- Author(s)
  渡邉寿人、岡田寛之、小俣康徳、齋藤琢、宮本健史、田中栄
- Organizer
  第6回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-21K09316
[Presentation] 半拘束型人工肘関節Discoveryの使用成績2021
- Author(s)
  小俣康徳、松本卓巳、田中栄
- Organizer
  第50回日本リウマチの外科学会
- Data Source
  KAKENHI-PROJECT-21K09316
[Presentation] 変形性膝関節症様の特徴をもつ関節リウマチ・膝関節症患者の増加～AIによる検証～2021
- Author(s)
  武田龍太郎、松本卓巳、前之原悠司、小俣康徳、永瀬雄一、西川卓治、田中栄
- Organizer
  第50回日本リウマチの外科学会
- Data Source
  KAKENHI-PROJECT-21K09316
[Presentation] 抗コラーゲン抗体関節炎マウスを用いたBaricitinibの疼痛抑制作用の解析2021
- Author(s)
  真壁健太、小俣康徳、淺香明子、柳原大、千々松良太、矢野文子、田中栄、齋藤琢
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-21K09294
[Presentation] KOACADシステムをも用いた生物学的製剤治療の有無による関節リウマチの膝関節単純X線画像的特徴についての検討2021
- Author(s)
  小俣康徳、岡敬之、小泉泰彦、門野夕峰、大橋暁、安井哲郎、大野久美子、廣瀬旬、松本卓巳、田中栄
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K09316

1. SAITO Taku (30456107)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
2. Tanaka Sakae (50282661)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. Matsumoto Takumi (70436468)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
4. 寺島明日香 (30596937)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. Taketomi Shuji (70570018)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 藤尾圭志 (70401114)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 矢野文子 (80529040)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 北條宏徳 (80788422)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 石倉久年 (80772904)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 橋爪洋 (10326382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小松紀子 (20553358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 吉村典子 (60240355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 岡田随象 (70727411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 岡田慶太 (50759173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 乾洋 (60583119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 高柳広 (20334229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 鈴木穣 (40323646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 森大典 (60835354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 大野久美子 (30444251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 土屋遥香 (50868560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 小笠原徹 (20359623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 細沼雅弘 (20836457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 三宅崇文 (10971997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 松林嘉孝 (50747962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 加藤壯 (50822061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 田中伸弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Omata Yasunori 小俣 康徳

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Establishment of novel cell therapies for joint diseases by activating innate immune systemPrincipal Investigator

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Elucidation of the mechanism of arthritis and establishment of therapeutic strategy by tissue-specific phenotypingPrincipal Investigator

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Osteoimmunology network between innate immunity and osteoclastPrincipal Investigator

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次世代シングルセル解析技術を用いた破骨細胞分化の制御機構の解明Principal Investigator

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[Journal Article] 骨粗鬆症の病態と治療2023

Author(s)

Omata Yasunori 小俣康徳