Heuser John ＨｅｕｓｅｒＪｏｈｎ

… Alternative Names

HEUSER John ホイザージョン

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Researcher Number	40571815
Other IDs
Affiliation (Current)	2025: 国際医療福祉大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 国際医療福祉大学, 医学部, 客員教授 2016: 京都大学, 物質-細胞統合システム拠点, 特定拠点教授 2011 – 2015: 京都大学, 物質-細胞統合システム拠点, 教授
Review Section/Research Field	Principal Investigator Basic Section 59010:Rehabilitation science-related / Physical pharmacy Except Principal Investigator Biological physics/Chemical physics/Soft matter physics / Nanomaterials/Nanobioscience
Keywords	Principal Investigator エンドサイトーシス / 電子顕微鏡 / 急速凍結 / ディープエッチ法 / 筋 / Aryscan / 合成ナノ粒子 / Airyscan / 膜融合 / 細胞膜 … More / 筋ジストロフィー / ディープエッチング / 急速凍結法 / electron microscopy / transfection / endocytosis / drug delivery / Electron microscopy / トランスフェクション / ドラッグデリバリー … More Except Principal Investigator 細胞骨格 / 細胞接着 / 神経細胞 / 細胞遊走 / 形状と運動 / 生命現象の物理 / 膜骨格 / 電子顕微鏡法 / クラスリン被覆ピット / アクチン膜骨格 / カベオラ / 分化 / 幹細胞 / 細胞 / 細胞膜 Less

'Deep-etch' electron microscopic analysis of intracellular introduction mechanism of new therapeutic compounds for muscular dystrophyPrincipal Investigator
- Principal Investigator
  
  Heuser John
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  International University of Health and Welfare
Non-Equilibrium Dynamics of Cytoskeleton During Cell Migration
- Principal Investigator
  
  Tanaka Motomu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological physics/Chemical physics/Soft matter physics
- Research Institution
  Kyoto University
'Deep-etch' electron microscopic analysis of the actual mechanism of entry of cell-penetrating nanoparticles used for drug and gene-delivery into living cellsPrincipal Investigator
- Principal Investigator
  
  Heuser John
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
Structural Changes by Plasma Membrane Differentiation
- Principal Investigator
  
  MORONE Nobuhiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nanomaterials/Nanobioscience
- Research Institution
  Kyoto University

All 2024 2022 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Defining the EM-signature of successful cell-transfection2024
- Author(s)
  Pemberton Joshua G.、Tenkova Tatyana、Felgner Philip、Zimmerberg Josh、Balla Tamas、Heuser John
- Journal Title
  
  bioRxiv
  
  Volume: 0 Pages: 0-0
- DOI
  10.1101/2024.03.07.583927
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11196
[Journal Article] The structural basis of long-term potentiation in hippocampal synapses, revealed by EM-imaging of lanthanum-induced synaptic vesicle recycling2022
- Author(s)
  Heuser JE
- Journal Title
  
  bioRxiv
  
  Volume: 10.1101 Pages: 489201-489201
- DOI
  10.1101/2022.04.22.489201
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11196
[Journal Article] Morphology and art in the work of Lelio Orci2022
- Author(s)
  Ribatti Domenico、Heuser John
- Journal Title
  
  Tissue and Cell
  
  Volume: 78 Pages: 101902-101902
- DOI
  10.1016/j.tice.2022.101902
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11196
[Journal Article] The Structural Basis of Long-Term Potentiation in Hippocampal Synapses, Revealed by Electron Microscopy Imaging of Lanthanum-Induced Synaptic Vesicle Recycling2022
- Author(s)
  Heuser John E.
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 16 Pages: 920360-920360
- DOI
  10.3389/fncel.2022.920360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11196
[Journal Article] The modeling of Alzheimer's disease by the overexpression of mutant Presenilin 1 in human embryonic stem cells.2016
- Author(s)
  Honda M, Minami I, Tooi N, Morone N, Nishioka H, Uemura K, Kinoshita A, Heuser JE, Nakatsuji N, Aiba K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 469 Issue: 3 Pages: 587-92
- DOI
  10.1016/j.bbrc.2015.12.025
- NAID
  120005980892
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253004, KAKENHI-PROJECT-26286027
[Journal Article] Mitochondrial fission protein Drp1 regulates mitochondrial transport and dendritic arborization in cerebellar Purkinje cells.2016
- Author(s)
  Fukumitsu, K., Hatsukano, T., Yoshimura, A., Heuser, J., Fujishima, K. and Kengaku, M.
- Journal Title
  
  Mol Cell Neurosci.
  
  Volume: 71 Pages: 56-65
- DOI
  10.1016/j.mcn.2015.12.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14317, KAKENHI-PROJECT-25253004, KAKENHI-PROJECT-26290005
[Journal Article] Synergistic action of dendritic mitochondria and creatine kinase maintains ATP homeostasis and actin dynamics in growing neuronal dendrites.2015
- Author(s)
  Kansai Fukumitsu, Kazuto Fujishima, Azumi Yoshimura, You Kure Wu, John Heuser, and Mineko Kengaku．
- Journal Title
  
  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｎｅｕｒｏｓｃｉｅｎｃｅ
  
  Volume: 35 Issue: 14 Pages: 5707-23
- DOI
  10.1523/jneurosci.4115-14.2015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J02523, KAKENHI-PROJECT-25830011, KAKENHI-PROJECT-26290005, KAKENHI-PROJECT-25253004
[Journal Article] Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.2015
- Author(s)
  Ishikawa Y, Maeda M, Pasham M, Aguet F, Tacheva-Grigorova SK, Masuda T, Yi H, Lee SU, Xu J, Teruya-Feldstein J, Ericsson M, Mullally A, Heuser J, Kirchhausen T, Maeda T.
- Journal Title
  
  Haematologica.
  
  Volume: 100 Issue: 4 Pages: 439-51
- DOI
  10.3324/haematol.2014.119537
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253004
[Journal Article] Eisosome Ultrastructure and Evolution in Fungi, Microalgae, and Lichens.2015
- Author(s)
  Lee JH, Heuser JE, Roth R, Goodenough U.
- Journal Title
  
  Eukaryot Cell.
  
  Volume: 14 Issue: 10 Pages: 1017-42
- DOI
  10.1128/ec.00106-15
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253004
[Journal Article] Some personal and historical notes on the utility of "deep-etch" electron microscopy for making cell structure/function correlations.2014
- Author(s)
  Heuser JE
- Journal Title
  
  Mol Biol Cell
  
  Volume: 25 Issue: 21 Pages: 3273-6
- DOI
  10.1091/mbc.e14-05-1016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253004
[Journal Article] Mesoscopic Metal Nanoparticles Doubly Functionalized with natural and engineered lipidic dispersants for therapeutics2014
- Author(s)
  Murakami, T., Nakatsuji, H., Morone, N., Heuser, J. E., Ishidate, F., Hashida, M., Imahori, H.
- Journal Title
  
  ACS Nano
  
  Volume: 8 Issue: 7 Pages: 7370-7376
- DOI
  10.1021/nn5024818
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24300162, KAKENHI-PROJECT-25253004, KAKENHI-PROJECT-26286027, KAKENHI-PUBLICLY-25104514
[Journal Article] Exclusive Photothermal Heat Generation by a Gadolinium Bis(naphthalocyanine) Complex and Inclusion into Modified High-Density Lipoprotein Nanocarriers for Therapeutic Applications2013
- Author(s)
  Mathew S, Murakami T, Nakatsuji H, Okamoto H, Morone N, Heuser JE, Hashida M, Imahori H.
- Journal Title
  
  ACS Nano.
  
  Volume: 7(10) Issue: 10 Pages: 8908-16
- DOI
  10.1021/nn403384k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310087, KAKENHI-PROJECT-24300162, KAKENHI-PROJECT-24650263, KAKENHI-PUBLICLY-25104514, KAKENHI-PROJECT-25253004
[Journal Article] Escherichia coli biofilms have an organized and complex extracellular matrix structure.2013
- Author(s)
  Hung C, Zhou Y, Pinkner JS, Dodson KW, Crowley JR, Heuser J, Chapman MR, Hadjifrangiskou M, Henderson JP, Hultgren SJ.
- Journal Title
  
  Mbio.
  
  Volume: 4 Issue: 5
- DOI
  10.1128/mbio.00645-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253004
[Journal Article] Nanoscale protein architecture of the kidney glomerular basement membrane.2013
- Author(s)
  Suleiman H, Zhang L, Roth R, Heuser JE, Miner JH, Shaw AS, Dani A.
- Journal Title
  
  Elife.
  
  Volume: 2
- DOI
  10.7554/elife.01149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253004
[Journal Article] Development of a reentrant arrhythmia model in human pluripotent stem cell-derivpd cardiac cell sheets2013
- Author(s)
  Kadota S, et al.
- Journal Title
  
  European Heart Journal
  
  Volume: VOL.34 Issue: 15 Pages: 1147-1156
- DOI
  10.1093/eurheartj/ehs418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J07076, KAKENHI-PROJECT-21340120, KAKENHI-PROJECT-23310087, KAKENHI-PROJECT-23710269
[Journal Article] Reduction of streptolysin O (SLO) pore-forming activity enhances inflammasome activation.2013
- Author(s)
  Keyel PA, Roth R, Yokoyama WM, Heuser JE, Salter RD.
- Journal Title
  
  Toxins (Basel).
  
  Volume: 5 Issue: 6 Pages: 1105-18
- DOI
  10.3390/toxins5061105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253004
[Journal Article] Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery2012
- Author(s)
  Tanaka T., Takahashi K., Yamane M., Tomida S., Nakamura S., Oshima K., Niwa A., Nishikomori R., Kambe N., Hara H., Mitsuyama M., Morone N., Heuse J.E., Yamamoto T., Watanabe A., Sato-Otsubo A., Ozawa S., Asaka I., Heike T., Yamanaka S., Nak
- Journal Title
  
  Blood
  
  Volume: 120(6) Issue: 6 Pages: 1299-308
- DOI
  10.1182/blood-2012-03-417881
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-22790283, KAKENHI-PROJECT-23310087, KAKENHI-PROJECT-23390280, KAKENHI-PROJECT-23657147, KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-24590524, KAKENHI-PROJECT-24659496
[Journal Article] A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions2012
- Author(s)
  Minami I, Yamada K, Otsuji TG, Yamamoto T, Shen Y, Otsuka S, Kadota S, Morone N, Barve M, Asai Y, Tenkova-Heuser T, Heuser JE, Uesugi M, Aiba K, Nakatsuji N
- Journal Title
  
  Cell Rep
  
  Volume: 2(5) Issue: 5 Pages: 1448-60
- DOI
  10.1016/j.celrep.2012.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310087, KAKENHI-PROJECT-23500446, KAKENHI-PROJECT-23710269, KAKENHI-PROJECT-24790755
[Presentation] Discovering the cause of adult-onset muscular dystrophy by electron microscopy of mouse genetic models.2016
- Author(s)
  John Heuser
- Organizer
  第１２１回日本解剖学会総会・学術集会
- Place of Presentation
  福島、日本
- Year and Date
  2016-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-25253004
[Presentation] Profound plasma membrane changes caused by acute cholesterol elevation2015
- Author(s)
  Azumi Yoshimura, Silvia Pujals, Nobuhiro Morone, Tanya Tenkova and John Heuser
- Organizer
  Biochemistry and Molecular Biology 2015
- Place of Presentation
  Kobe, Japan
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-25253004
[Presentation] The future of electron microscopy: Challenges that remain2014
- Author(s)
  John Heuser
- Organizer
  認定NPO法人綜合画像研究支援　創立十周年記念学術講演会
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2014-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-25253004
[Presentation] キャビンとカベオラ分子構築に関する構造解析的検証2013
- Author(s)
  諸根信弘、ロブ・パートン、ジョン・ホイザー
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  ウィンクあいち
- Data Source
  KAKENHI-PROJECT-23310087
[Presentation] Dendra融合タンパク質によるカベオラの急速凍結・ディープエッチ電子顕微鏡法2013
- Author(s)
  諸根信弘、吉村安寿弥、ホイザー・ジョン
- Organizer
  日本顕微鏡学会第69回学術講演会
- Place of Presentation
  大阪
- Year and Date
  2013-05-20
- Data Source
  KAKENHI-PROJECT-23310087
[Presentation] チュートリアル：凍結割断の像の読み方2013
- Author(s)
  諸根信弘、ホイザー・ジョン
- Organizer
  日本顕微鏡学会第69回学術講演会
- Place of Presentation
  ホテル阪急エキスポパーク、大阪
- Invited
- Data Source
  KAKENHI-PROJECT-23310087
[Presentation] Dendra融合タンパク質によるカベオラの急速凍結・ディープエッチ電子顕微鏡法2013
- Author(s)
  諸根信弘、吉村安寿弥、ホイザー・ジョン
- Organizer
  日本顕微鏡学会第69回学術講演会
- Place of Presentation
  ホテル阪急エキスポパーク、大阪
- Data Source
  KAKENHI-PROJECT-23310087
[Presentation] チュートリアル：フリーズエッチングの基礎と実践2013
- Author(s)
  諸根信弘、ホイザー・ジョン
- Organizer
  日本顕微鏡学会第69回学術講演会
- Place of Presentation
  ホテル阪急エキスポパーク、大阪
- Invited
- Data Source
  KAKENHI-PROJECT-23310087
[Presentation] Plasma Membrane Architecture Reconstructed By Small Convergence-Angle HAADF-STEM Freeze-etch Tomography : Improvement of the Quality in Tomogram2011
- Author(s)
  Morone N, Heuser J, Aoyama K
- Organizer
  EMBL Conference : Sixth International Congress on Electron Tomography
- Place of Presentation
  ハイデルベルグ(ドイツ)
- Year and Date
  2011-05-06
- Data Source
  KAKENHI-PROJECT-23310087
[Presentation] How can we image cells best in the electron microscope?
- Author(s)
  John Heuser
- Organizer
  大阪市立大学理学部生物学科セミナーシリーズ
- Place of Presentation
  大阪市立大学
- Invited
- Data Source
  KAKENHI-PROJECT-25253004
[Presentation] The application of "deep-etch" electron microscpy to modern cell biology research
- Author(s)
  John Heuser
- Organizer
  John Hopkins University, Department of Biology: Departmental Seminar
- Place of Presentation
  John Hopkins University
- Invited
- Data Source
  KAKENHI-PROJECT-25253004
[Presentation] E.B. Wilson Medal Presentation: A personal history of EM-visualization of the cytoskeleton
- Author(s)
  John Heuser
- Organizer
  The 2014 ASCB/ ifcb meeting
- Place of Presentation
  philadelphia, USA
- Year and Date
  2014-12-06 – 2014-12-10
- Invited
- Data Source
  KAKENHI-PROJECT-25253004
[Presentation] The Future of microscopy: Challenges left to overcome
- Author(s)
  John Heuser
- Organizer
  綜合画像研究支援１０周年記念講演会
- Place of Presentation
  東京大学
- Invited
- Data Source
  KAKENHI-PROJECT-25253004
[Presentation] Future challenges and opportunities in biological electron microscopy
- Author(s)
  John Heuser
- Organizer
  Opening International Symposium, Next-Generation Microscopic Science, Japanese Society of Microscopy
- Place of Presentation
  Awaji, Japan
- Year and Date
  2014-11-03 – 2014-11-04
- Invited
- Data Source
  KAKENHI-PROJECT-25253004
[Presentation] Synaptic vesicle recycling revisited
- Author(s)
  John Heuser
- Organizer
  Howard Hughes Medical Institute Conference on Synaptic Vesicle Biogenesis
- Place of Presentation
  Howard Hughes Medical Institute
- Invited
- Data Source
  KAKENHI-PROJECT-25253004

1. MORONE Nobuhiro (50399680)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. Murakami Tatsuya (90410737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. Tanaka Motomu (00706814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TSURUYAMA Tatsuaki (00303842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YOSHIKAWA Hiroshi (50551173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YOSHIKAWA Kenichi (80110823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 見学美根子 (10303801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 三宅克也 (30219745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山田晋之介 (30772123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OSHIMA Koichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. NIWA Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Heuser John Ｈｅｕｓｅｒ Ｊｏｈｎ

HEUSER John ホイザー ジョン

Research Projects

Research Products

Co-Researchers

'Deep-etch' electron microscopic analysis of intracellular introduction mechanism of new therapeutic compounds for muscular dystrophyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Non-Equilibrium Dynamics of Cytoskeleton During Cell Migration

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

'Deep-etch' electron microscopic analysis of the actual mechanism of entry of cell-penetrating nanoparticles used for drug and gene-delivery into living cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural Changes by Plasma Membrane Differentiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Defining the EM-signature of successful cell-transfection2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The structural basis of long-term potentiation in hippocampal synapses, revealed by EM-imaging of lanthanum-induced synaptic vesicle recycling2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Morphology and art in the work of Lelio Orci2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Structural Basis of Long-Term Potentiation in Hippocampal Synapses, Revealed by Electron Microscopy Imaging of Lanthanum-Induced Synaptic Vesicle Recycling2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The modeling of Alzheimer's disease by the overexpression of mutant Presenilin 1 in human embryonic stem cells.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Mitochondrial fission protein Drp1 regulates mitochondrial transport and dendritic arborization in cerebellar Purkinje cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synergistic action of dendritic mitochondria and creatine kinase maintains ATP homeostasis and actin dynamics in growing neuronal dendrites.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Eisosome Ultrastructure and Evolution in Fungi, Microalgae, and Lichens.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Some personal and historical notes on the utility of "deep-etch" electron microscopy for making cell structure/function correlations.2014

Author(s)

Journal Title

DOI

Data Source

Heuser John ＨｅｕｓｅｒＪｏｈｎ

HEUSER John ホイザージョン