Toshie Kai 甲斐歳恵

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KAI TOSHIE 甲斐歳恵

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Researcher Number	40579786
Other IDs	https://orcid.org/0000-0001-8675-8469
Affiliation (Current)	2025: 大阪大学, 大学院生命機能研究科, 教授 2025: 京都大学, 生命科学研究科, 教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 大阪大学, 大学院生命機能研究科, 教授 2015 – 2021: 大阪大学, 生命機能研究科, 教授 2014: 大阪大学, 生命機能研究科, 招へい教授
Review Section/Research Field	Principal Investigator Basic Section 43010:Molecular biology-related / Transformative Research Areas, Section (III) / Biological Sciences / Developmental biology Except Principal Investigator Transformative Research Areas, Section (III)
Keywords	Principal Investigator piRNA / 生殖細胞 / ヌアージュ / 非膜オルガネラ / 非ドメイン型タンパク質 / 小分子RNA / 染色体高次構造 / 塩基修飾 / 全能性 / 生殖幹細胞 … More / エピジェネティックス / 6mA修飾 / HemK2 / DamID / 転写因子 / キイロショウジョウバエ / ピンポン増幅 / Tudor domain / トランスポゾン / germline / Drosophila meganogaster / 発生・分化 / 非コードRNA … More Except Principal Investigator 天然変性領域 / lncRNA / ゲノム編集 / 超天然変性タンパク質 / 相分離 / 天然変性タンパク質 / ノンコーディングRNA / 非ドメイン型RNA / 非ドメイン型タンパク質 / 非ドメイン型バイオポリマー Less

非膜オルガネラ・ヌアージュとRNAヘリカーゼによる生殖細胞ゲノム保護機構Principal Investigator
- Principal Investigator
  
  甲斐歳恵
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  The University of Osaka
Management of non-domain biopolymer research group
- Principal Investigator
  
  中川真一
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Hokkaido University
Molecular mechanism of piRNA biogenesis and nuage formation involving Tudor domain proteinsPrincipal Investigator
- Principal Investigator
  
  KAI Toshie
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Osaka University
Genetic analysis of nuage formation regulated by non-domain type proteinsPrincipal Investigator
- Principal Investigator
  
  甲斐歳恵
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Osaka
生殖幹細胞の全能性を保障する多階層的な非ゲノム情報の複製機構の解明Principal Investigator
- Principal Investigator
  
  甲斐歳恵
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Elucidation of piRNA biogenesis involving Tudor domain proteinsPrincipal Investigator
- Principal Investigator
  
  Kai Toshie
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Osaka University
Molecular mechanism of germline maintenance and differentiation via long-noncoding RNAsPrincipal Investigator
- Principal Investigator
  
  KAI TOSHIE
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018 2016 2015

All Journal Article Presentation

[Journal Article] piRNA processing within non-membrane structures is governed by constituent proteins and their functional motifs2024
- Author(s)
  Ritsuko Suyama, Toshie Kai
- Journal Title
  
  The FEBS Journal
  
  Volume: - Issue: 11 Pages: 2715-2736
- DOI
  10.1111/febs.17360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21H05275
[Journal Article] HemK2 functions for sufficient protein synthesis and RNA stability through eRF1 methylation during Drosophila oogenesis2024
- Author(s)
  Fengmei Xu, Ritsuko Suyama, Toshifumi Inada, Shinichi Kawaguchi, Toshie Kai
- Journal Title
  
  Development
  
  Volume: 151 Issue: 14
- DOI
  10.1242/dev.202795
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21H05275
[Journal Article] Nondomain biopolymers: Flexible molecular strategies to acquire biological functions2023
- Author(s)
  Arakawa K, Hirose T, Inada T, Ito T, Kai T, Oyama M, Tomari Y, Yoda T, Nakagawa S.
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 8 Pages: 539-552
- DOI
  10.1111/gtc.13050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19246, KAKENHI-ORGANIZER-21H05273, KAKENHI-PLANNED-21H05274, KAKENHI-PLANNED-21H05275, KAKENHI-PLANNED-21H05276, KAKENHI-PLANNED-21H05278, KAKENHI-PLANNED-21H05279, KAKENHI-PLANNED-21H05280, KAKENHI-PLANNED-21H05281, KAKENHI-PLANNED-21H05282, KAKENHI-PROJECT-21H02401, KAKENHI-PROJECT-23H00364
[Journal Article] miRNA/siRNA-directed pathway to produce noncoding piRNAs from endogenous protein-coding regions ensures <i>Drosophila</i> spermatogenesis2023
- Author(s)
  Iki Taichiro、Kawaguchi Shinichi、Kai Toshie
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 29 Pages: 1-15
- DOI
  10.1126/sciadv.adh0397
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06081, KAKENHI-PLANNED-21H05275, KAKENHI-PROJECT-21H02401
[Journal Article] Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis2023
- Author(s)
  Yuxuan Lin, Ritsuko Suyama, Shinichi Kawaguchi, Taichiro Iki, Toshie Kai
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 222(10) Issue: 10
- DOI
  10.1083/jcb.202303125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21H05275, KAKENHI-PROJECT-21H02401
[Journal Article] The Tudor Domain-Containing Protein, Kotsubu (CG9925), Localizes to the Nuage and Functions in piRNA Biogenesis in D. melanogasterr2022
- Author(s)
  Lin-Xenia Lim, Wakana Isshiki, Taichiro Iki, Shinichi Kawaguchi, Toshie Kai
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 9 Pages: 818302-818302
- DOI
  10.3389/fmolb.2022.818302
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06628, KAKENHI-PROJECT-21H02401, KAKENHI-PLANNED-21H05275
[Journal Article] Stem cells orchestrate oogenesis: a lesson from the fruit fly, Drosophila melanogaster2020
- Author(s)
  Niwa R, Kai T
- Journal Title
  
  Curr. Opin. Insect Sci
  
  Volume: 37 Pages: 3-5
- DOI
  10.1016/j.cois.2020.03.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02375
[Journal Article] Modulation of Ago2 Loading by Cyclophilin 40 Endows a Unique Repertoire of Functional miRNAs during Sperm Maturation in Drosophila2020
- Author(s)
  Iki T, Takami M, Kai T
- Journal Title
  
  Cell Reports
  
  Volume: 33 Issue: 6 Pages: 108380-393
- DOI
  10.1016/j.celrep.2020.108380
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02375, KAKENHI-PROJECT-18K06059
[Journal Article] Protecting and Diversifying the Germline2018
- Author(s)
  Gleason Ryan J.、Anand Amit、Kai Toshie、Chen Xin
- Journal Title
  
  Genetics
  
  Volume: 208 Issue: 2 Pages: 435-471
- DOI
  10.1534/genetics.117.300208
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291048
[Journal Article] Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila2018
- Author(s)
  Teo Ryan Yee Wei, Anand Amit, Sridhar Vishweshwaren, Okamura Katsutomo, Kai Toshie
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1735-1735
- DOI
  10.1038/s41467-018-03908-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02375
[Journal Article] Role of Heterochromatin Protein 1a in pericentric and telomeric piRNA biogenesis in the Drosophila germline2018
- Author(s)
  Ryan Yee Wei Teo, Amit Anand, Vishweshwaren Sridhar, Katsutomo Okamura, Toshie Kai
- Journal Title
  
  Nature Communications
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291048
[Journal Article] The piRNA pathway is developmentally regulated during spermatogenesis in Drosophila2016
- Author(s)
  Quenerch’du E, Anand A and Kai T
- Journal Title
  
  RNA
  
  Volume: 22 Issue: 7 Pages: 1044-1054
- DOI
  10.1261/rna.055996.116
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291048
[Journal Article] A piece of the pi(e): the diverse roles of animal piRNAs and their PIWI partners2015
- Author(s)
  Lim RSM and Kai T
- Journal Title
  
  Sem. Cell Dev. Biol.
  
  Volume: 47-48 Pages: 17-31
- DOI
  10.1016/j.semcdb.2015.10.025
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291048
[Presentation] 生殖細胞特異的な皮膜オルガネラ・ヌアージュの構造と機能2023
- Author(s)
  甲斐歳恵
- Organizer
  第33回フォーラム・イン・ドージン
- Invited
- Data Source
  KAKENHI-PROJECT-21H02401
[Presentation] 生殖細胞特異的な皮膜オルガネラ・ヌアージュの構造と機能2023
- Author(s)
  甲斐歳恵
- Organizer
  第33回フォーラム・イン・ドージン
- Invited
- Data Source
  KAKENHI-PLANNED-21H05275
[Presentation] 生殖細胞特異的な非膜オルガネラ・ヌアージュの構築原理と機能2023
- Author(s)
  甲斐歳恵
- Organizer
  学術変革領域「非ドメイン生物学」領域班会議
- Data Source
  KAKENHI-PLANNED-21H05275
[Presentation] Identification of PIWI-interactors by BioID in Drosophila ovary2022
- Author(s)
  甲斐歳恵
- Organizer
  学術変革領域「非ドメイン生物学」領域班会議
- Data Source
  KAKENHI-PLANNED-21H05275
[Presentation] Tejas Functions in piRNA Biogenesis via Nuage Assembly in Drosophila2022
- Author(s)
  甲斐歳恵
- Organizer
  2022 EMBO Workshop on PIWI Proteins and piRNAs
- Data Source
  KAKENHI-PLANNED-21H05275
[Presentation] eRF1 methylation ensures proper oogenesis in Drosophila melanogaster2022
- Author(s)
  甲斐歳恵
- Organizer
  学術変革領域「非ドメイン生物学」領域班会議
- Data Source
  KAKENHI-PLANNED-21H05275
[Presentation] Germline cell protection by Stand still (Stil), a female-restricted BED-type zinc finger protein in Drosophila melanogaster2021
- Author(s)
  松井　将也、河口　真一、須山　律子、甲斐　歳惠
- Organizer
  第14回日本ショウジョウバエ研究集会
- Data Source
  KAKENHI-PUBLICLY-20H05390
[Presentation] ショウジョウバエにおけるTejasとSpn-EによるpiRNA生合成のためのヌアージュ構築の分子基盤2021
- Author(s)
  Lin Yuxuan, Kawaguchi Shinichi, Iki Taichiro, Suyama Ritsuko, Kai Toshie
- Organizer
  第44回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02401
[Presentation] ショウジョウバエにおけるTejasとSpn-EによるpiRNA生合成のためのヌアージュ構築の分子基盤2021
- Author(s)
  Lin Yuxuan, Kawaguchi Shinichi, Iki Taichiro, Suyama Ritsuko, Kai Toshie
- Organizer
  第44回分子生物学会年会
- Data Source
  KAKENHI-PLANNED-21H05275
[Presentation] HemK2 is required for Otu-mediated proper chromosome dispersion during oogenesis and egg maturation in Drosophila melanogaster.2021
- Author(s)
  Fengmei, Xu、河口真一、甲斐歳恵
- Organizer
  第44回分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-20H05390
[Presentation] Stand still (Stil)によるショウジョウバエ生殖細胞保護機構2021
- Author(s)
  松井　将也、河口　真一、須山　律子、甲斐　歳惠
- Organizer
  第44回分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-20H05390
[Presentation] dTdrd1 functions in piRNA pathway in Drosophila2020
- Author(s)
  Toshie Kai
- Organizer
  Asia Pacific Drosophila Research Conference 5
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02375
[Presentation] piRNAs safegurd germline genome from transposons2020
- Author(s)
  Toshie Kai
- Organizer
  Asia Pacific Drosophila Research Conference 5
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02375
[Presentation] 微生物が誘導するショウジョウバエ卵形成促進機構の解明2019
- Author(s)
  須山律子、セトラロニコラス、イウジョアンヌ、甲斐歳恵
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02375
[Presentation] Tissue-specific regulation of RISC loading by Hsp90 cochaperone Cyclophilin 402019
- Author(s)
  Taichiro Iki, Moe Takami, Toshie Kai
- Organizer
  RNA 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02375
[Presentation] 腸内微生物による卵形成亢進機構の解明2019
- Author(s)
  Ritsuko Suyama, Nicolas Cetraro, Joanne Y. Yew, Toshie Kai
- Organizer
  第52回日本発生生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02375
[Presentation] Hsp90 コシャペロン Cyclophilin 40 はショウジョウバエにおける精子形成に必須の役割を果たす2019
- Author(s)
  高見萌、井木太一郎、甲斐歳恵
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02375
[Presentation] ショウジョウバエ生殖幹細胞に特異的な発現遺伝子、スプライシング、RNA塩基修飾の探索2019
- Author(s)
  河口真一、アナンドアミット、甲斐歳恵
- Organizer
  RNAフロンティアミーティング2019
- Data Source
  KAKENHI-PROJECT-18H02375
[Presentation] Role of Drosophila Meiosis Arrest Female protein-1 (dMarf1) in oocyte2018
- Author(s)
  河口真一、甲斐歳惠
- Organizer
  The 4th Asia-Pacific Drosophila Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291048
[Presentation] Tudor Domain Proteins and Small Interfering RNAs Protects Germline Cells2018
- Author(s)
  甲斐歳惠
- Organizer
  The International Conference of the Genetics Society of Korea 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291048
[Presentation] 選択的スプライシングによって制御される生殖幹細胞のトランスクリプトーム2018
- Author(s)
  河口真一、Amit Anand、甲斐歳恵
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02375
[Presentation] ショウジョウバエのdMarf1は、NanosのmRNAに結合し、減数分裂の再開を引き起こす2018
- Author(s)
  植木美月、河口真一、甲斐歳惠
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02375
[Presentation] HP1a は進化的に古いトランスポゾンとテロメア領域にあるトランスポゾンを piRNA 経路によって抑制する2016
- Author(s)
  アナンドアミット、イーウェイテオ、岡村勝友、甲斐歳恵
- Organizer
  日本遺伝学会第88回大会
- Place of Presentation
  日本大学（静岡県三島市）
- Invited
- Data Source
  KAKENHI-PROJECT-26291048

1. 中川真一 (50324679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 荒川和晴 (40453550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 廣瀬哲郎 (30273220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 尾山大明 (30422398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 稲田利文 (40242812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 依田隆夫 (50367900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 伊藤拓宏 (70401164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 泊幸秀 (90447368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 河口真一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 井木太一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Toshie Kai 甲斐 歳恵

KAI TOSHIE 甲斐 歳恵

Research Projects

Research Products

Co-Researchers

非膜オルガネラ・ヌアージュとRNAヘリカーゼによる生殖細胞ゲノム保護機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Management of non-domain biopolymer research group

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of piRNA biogenesis and nuage formation involving Tudor domain proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genetic analysis of nuage formation regulated by non-domain type proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生殖幹細胞の全能性を保障する多階層的な非ゲノム情報の複製機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of piRNA biogenesis involving Tudor domain proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of germline maintenance and differentiation via long-noncoding RNAsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] piRNA processing within non-membrane structures is governed by constituent proteins and their functional motifs2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HemK2 functions for sufficient protein synthesis and RNA stability through eRF1 methylation during Drosophila oogenesis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nondomain biopolymers: Flexible molecular strategies to acquire biological functions2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miRNA/siRNA-directed pathway to produce noncoding piRNAs from endogenous protein-coding regions ensures <i>Drosophila</i> spermatogenesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Tudor Domain-Containing Protein, Kotsubu (CG9925), Localizes to the Nuage and Functions in piRNA Biogenesis in D. melanogasterr2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stem cells orchestrate oogenesis: a lesson from the fruit fly, Drosophila melanogaster2020

Author(s)

Journal Title

Toshie Kai 甲斐歳恵

KAI TOSHIE 甲斐歳恵