Kojima Takahiro 小島崇宏

… Alternative Names

Researcher Number	40626892
Affiliation (Current)	2021: 愛知県がんセンター(研究所), 腫瘍制御学分野, 研究員
Affiliation (based on the past Project Information) *help	2019 – 2020: 筑波大学, 医学医療系, 准教授 2012 – 2018: 筑波大学, 医学医療系, 講師
Review Section/Research Field	Principal Investigator Urology / Basic Section 56030:Urology-related Except Principal Investigator Basic Section 56030:Urology-related / Urology / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Medium-sized Section 50:Oncology and related fields
Keywords	Principal Investigator 肉腫様腎細胞癌 / 遺伝子異常 / DNAコピー数異常 / マイクロアレイ / 腎細胞癌 / 低分子量Gタンパク / 肉腫様変化 / SNP / cfDNA / 膀胱癌 … More Except Principal Investigator 尿路上皮癌 / 腫瘍免疫 / ミコール酸 / TDM / 癌免疫 / BCG / gankyrin / testicular cancer / 精巣腫瘍 / ガンキリン / 奇形腫 / 悪性転化 / Rb / モルモット膀胱癌 / 脂質免疫 / Mycobacterium bovis BCG / CD1b / Mincle / Trem2 / Mycobacterium bovie BCG / モルモットモデル / ノックアウトマウス / 腫瘍微小環境 / 発癌 / PD-L1 / 遺伝子変異 / 免疫環境 / がん微小環境 / がん免疫応答 / クローン造血 / マウスモデル / メラノーマ / TET2 / 炎症細胞 / 微小環境 / 骨格筋間質由来幹細胞 / 膀胱機能障害病態モデル / 膀胱放射線照射モデル / 幹細胞移植 / 神経因性膀胱 / 感覚受容体 / ASIC / ENaC / 膀胱発癌 / 筋層浸潤膀胱癌 / 排尿障害モデル / AISC / ENac / 閉経モデルマウス / ASIC/ENaC / 癌免疫療法 / 脂質 / リポソーム / リンパ球 / 抗酸菌 / 感染免疫 / 細胞壁成分 / 膀胱癌 / trehalose-6 6’-dimycolate / 抗酸菌表層糖脂質 / mycobacterium bovis BCG / 低活動膀胱 / アデノシン / 骨盤神経損傷モデル / FGFR3 / リピドミクス / 膀胱腫瘍 / 機能性ペプチド / p16 / p14 / p19 / 膀胱移植モデル / 膀胱注入 / anti-tumor peptide / bladder tumor / bladder instillation / 腎癌 / CTC / リキッドバイオプシー / 泌尿器癌 Less

To elucidate the pathophysiological mechanism and explore the therapeutic target of underactive bladder / detrusor underactivity with focusing on the adenosine signaling pathwayOngoing
- Principal Investigator
  
  高岡栄一郎
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  International University of Health and Welfare
膀胱がんにおける脂肪酸の質の意義の解明：脂肪酸伸長酵素ELOVL6に着目してOngoing
- Principal Investigator
  
  松坂賢
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  University of Tsukuba
Efficacy and toxicity of bladder instillation of anti-tumor peptide for inhibition of bladder tumor in miceOngoing
- Principal Investigator
  
  島居徹
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Tsukuba
クラスターCTCに注目した泌尿器癌の分子基盤に基づいたバイオマーカーの開発
- Principal Investigator
  
  松岡妙子
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Tsukuba
Tumor-supporting mechanisms by inflammatory cells with somatic mutations
- Principal Investigator
  
  Sakata-Yanagimoto Mamiko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  University of Tsukuba
Development of novel molecular characterization for urothelial cancer based on genetic and environmental factorsPrincipal InvestigatorOngoing
- Principal Investigator
  
  小島崇宏
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Tsukuba
The establishment of a novel treatment in neurogenic bladder by the transplantation of the stem cells derived from the skeletal muscle stromaOngoing
- Principal Investigator
  
  星昭夫
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Tsukuba
ASIC/ ENaC を介した膀胱癌の発癌と浸潤機序の解明Ongoing
- Principal Investigator
  
  西山博之
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  University of Tsukuba
抗酸菌表層糖脂質をリード化合物とする新規癌免疫治療法の開発Ongoing
- Principal Investigator
  
  西山博之
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Tsukuba
Elucidation of BCG resistance mechanism by comprehensive analysis of immune environment and gene mutation in bladder cancer
- Principal Investigator
  
  Joraku Akira
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  University of Tsukuba
Clarification of the tumor microenvironment in the development of urothelial carcinoma using animal model
- Principal Investigator
  
  Nishiyama Hiroyuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  University of Tsukuba
The roles of RAC2-VAV1 signaling in oncogenesis and sarcomatoid differentiation of renal cell carcinomaPrincipal Investigator
- Principal Investigator
  
  Kojima Takahiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  University of Tsukuba
Expression of the oncoprotein gankyrin and phosphorylated retinoblastoma protein in human testis and testicular germ cell tumor
- Principal Investigator
  
  SUETOMI TAKAHIRO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  University of Tsukuba
Identification of characteristic gene expression and molecular target in sarcomatoid renal cell carcinomaPrincipal Investigator
- Principal Investigator
  
  KOJIMA Takahiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  University of Tsukuba

All 2019 2018 2017 2016 2014 2013 2012

All Journal Article Presentation

[Journal Article] Cationized liposomal keto-mycolic acids isolated from Mycobacterium bovis bacillus Calmette-Guerin induce antitumor immunity in a syngeneic murine bladder cancer model.2019
- Author(s)
  Yoshino Takayuki、Miyazaki Jun、Kojima Takahiro、Kandori Shuya、Shiga Masanobu、Kawahara Takashi、Kimura Tomokazu、Naka Takashi、Kiyohara Hideyasu、Watanabe Miyuki、Yamasaki Sho、Akaza Hideyuki、Yano Ikuya、Nishiyama Hiroyuki
- Journal Title
  
  PLoS One.
  
  Volume: 14 Pages: 1-19
- DOI
  10.1371/journal.pone.0209196
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-18H02934, KAKENHI-PROJECT-17K16774, KAKENHI-PROJECT-17K11124, KAKENHI-PROJECT-17H04087
[Journal Article] TP53 codon 72 polymorphism is associated with FGFR3 and RAS mutation in non-muscle-invasive bladder cancer2019
- Author(s)
  Kawahara Takashi、Kojima Takahiro、Kandori Shuya、Kurobe Masahiro、Yoshino Takayuki、Kimura Tomokazu、Nagumo Yoshiyuki、Ishituka Ryutaro、Mitsuzuka Koji、Narita Shintaro、Kobayashi Takashi、Matsui Yoshiyuki、Ogawa Osamu、Sugimoto Mikio、Miyazaki Jun、Nishiyama Hiroyuki
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Pages: 220173-220173
- DOI
  10.1371/journal.pone.0220173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09158, KAKENHI-PROJECT-19K09664
[Journal Article] High prevalence of hypogonadism determined by serum free testosterone level in Japanese testicular cancer survivors2018
- Author(s)
  Kurobe Masahiro、Kawai Koji、Suetomi Takahiro、Iwamoto Teruaki、Waku Natsui、Kawahara Takashi、Kojima Takahiro、Joraku Akira、Miyazaki Jun、Nishiyama Hiroyuki
- Journal Title
  
  International Journal of Urology
  
  Volume: in print
- DOI
  10.1111/iju.13537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293349
[Journal Article] TRPV4-dependent induction of a novel mammalian cold-inducibel protein SRSF5 as well as CIRP and RBM3.2017
- Author(s)
  Fujita Takanori、Higashitsuji Hiroaki、Higashitsuji Hisako、Liu Yu、Itoh Katsuhiko、Sakurai Toshiharu、Kojima Takahiro、Kandori Shuya、Nishiyama Hiroyuki、Fukumoto Motoi、Fukumoto Manabu、Shibasaki Koji、Fujita Jun
- Journal Title
  
  Sci Rep
  
  Volume: 7 Pages: 2295-2295
- DOI
  10.1038/s41598-017-02473-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16774, KAKENHI-PROJECT-26293349, KAKENHI-PUBLICLY-16H01387, KAKENHI-PROJECT-15H03000, KAKENHI-PROJECT-16K15571
[Journal Article] Possible risk of overestimation of renal function using cystatin C-based eGFR in testicular cancer survivors treated with cisplatin-based chemotherapy2017
- Author(s)
  Ichioka Daishi、Kawai Koji、Tanaka Ken、Ishitsuka Ryutaro、Yoshino Takayuki、Kimura Tomokazu、Kandori Shuya、Kawahara Takashi、Kojima Takahiro、Usui Joichi、Yamagata Kunihiro、Miyazaki Jun、Nishiyama Hiroyuki
- Journal Title
  
  Clinical and Experimental Nephrology
  
  Volume: in print
- DOI
  10.1007/s10157-017-1474-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16774, KAKENHI-PROJECT-26293349
[Journal Article] Development of RNA-FISH Assay for Detection of Oncogenic FGFR3-TACC3 Fusion Genes in FFPE Samples.2016
- Author(s)
  7)Kurobe M, Kojima T, Nishimura K, Kandori S, Kawahara T, Yoshino T, Ueno S, Iizumi Y, Mitsuzuka K, Arai Y, Tsuruta H, Habuchi T, Kobayashi T, Matsui Y, Ogawa O, Sugimoto M, Kakehi Y, Nagumo Y, Tsutsumi M, Oikawa T, Kikuchi K, Nishiyama H.
- Journal Title
  
  PLoS One.
  
  Volume: 11
- DOI
  10.1371/journal.pone.0165109
- NAID
  120005941365
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H02679, KAKENHI-PROJECT-26293349
[Journal Article] Expression of the oncoprotein gankyrin and phosphorylated retinoblastoma protein in human testis and testicular germ cell tumor.2014
- Author(s)
  Satoshi Ando, Taeko Matsuoka, Koji Kawai, Shintaro Sugita, Akira Joraku, Takahiro Kojima, Takahiro Suetomi, Jun Miyazaki, Jun Fujita and Hiroyuki Nishiyama
- Journal Title
  
  Int J Urol.
  
  Volume: 21 Pages: 992-998
- DOI
  10.1111/iju.12484
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592376, KAKENHI-PROJECT-24592446
[Journal Article] Systemic transduction of p16INK4A antitumor peptide2013
- Author(s)
  Shimazui T, Uchida K, et al
- Journal Title
  
  Int J Oncol.
  
  Volume: 42 Pages: 8-543
- DOI
  10.3892/ijo.2012.1752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590282, KAKENHI-PROJECT-23592330, KAKENHI-PROJECT-24592375, KAKENHI-PROJECT-24592415, KAKENHI-PROJECT-24791634
[Journal Article] Case of metastatic malignant melanoma of the urinary bladder2013
- Author(s)
  Ikeda A, Miyagawa T, Kurobe M, Uchida M, Kojima T, Tsutsumi M, Ito S, Sugita S, Nishiyama H
- Journal Title
  
  Hinyokika Kiyo
  
  Volume: 59(9) Pages: 579-82
- NAID
  120005333767
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791634
[Journal Article] Oncological outcomes of metastatic testicular cancers under centralized management through regional medical network2013
- Author(s)
  Inai H, Kawai K, Kojima T, Joraku A, Shimazui T, Yamauchi A, Miyagawa T, Endo T, Fukuhara Y, Miyazaki J, Uchida K, Nishiyama H
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 43(12) Pages: 1249-54
- DOI
  10.1093/jjco/hyt152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791634
[Journal Article] Management of ureteral obstruction in advanced testicular tumor with lymph node metastasis2012
- Author(s)
  Ikeda A, Kawai K, Miyazaki J, Nishiyama H.
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 42(8) Pages: 748-52
- DOI
  10.1093/jjco/hys094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592330, KAKENHI-PROJECT-24791634
[Journal Article] A case of acute adrenal insufficiency unmasked during sunitinib treatment for metastatic renal cell carcinoma2012
- Author(s)
  Yoshino T, Kawai K, Miyazaki J, Kimura T, Ikeda A, Takaoka E, Suetomi T, Oikawa T, Kojima T, Iwasaki H, Shimano H, Nishiyama H
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 42(8) Pages: 764-6
- DOI
  10.1093/jjco/hys070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791634
[Journal Article] Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice2012
- Author(s)
  Oishi H et al.
- Journal Title
  
  J Biochem
  
  Volume: 152 Pages: 549-549
- DOI
  10.1093/jb/mvs100
- NAID
  10031166173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390115, KAKENHI-PROJECT-22590282, KAKENHI-PROJECT-23590325, KAKENHI-PROJECT-24791634
[Journal Article] Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.2012
- Author(s)
  Takase H, Matsumoto H, Yamadera R, Kubota Y, Otsu A, Suzuki R, Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S, Ema M
- Journal Title
  
  Blood
  
  Volume: 120 Pages: 914-23
- DOI
  10.1182/blood-2011-12-398156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220009, KAKENHI-PROJECT-22590282, KAKENHI-PROJECT-23500488, KAKENHI-PROJECT-24791634, KAKENHI-PUBLICLY-23122503
[Presentation] Antitumor effect of cationic liposome incorporating keto-mycolic acid from Mycobacterium bovis bacillus Calmette-Guerin in mouse model.2018
- Author(s)
  Takayuki Yoshino, Jun Miyazaki, Takahiro Kojima, Shuya Kandori, Hideyuki Akaza, Ikuya Yano, Hiroyuki Nishiyama
- Organizer
  ASCO-GU
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02934
[Presentation] Germline TP53 codon72 is associated with FGFR3 and RAS mutation and FGF signals in bladder cancer2018
- Author(s)
  河原貴史、小島崇宏、木村友和、河合弘二、西山博之
- Organizer
  第77回日本癌学会
- Data Source
  KAKENHI-PROJECT-18K09158

1. Nishiyama Hiroyuki (20324642)

# of Collaborated Projects: 8 results

# of Collaborated Products: 11 results
2. 宮崎淳 (10550246)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
3. 河合弘二 (90272195)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
4. 高岡栄一郎 (50625340)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 神鳥周也 (50707825)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
6. SUETOMI TAKAHIRO (10574650)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. Joraku Akira (60436277)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 島居徹 (80235613)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 木村友和 (10633191)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. Sakata-Yanagimoto Mamiko (80451805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 野口雅之 (00198582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 日下部学 (40804381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 河原貴史 (50758919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 星昭夫 (90453711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 根来宏光 (80708595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 松坂賢 (70400679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 吉川和宏 (60109759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 松岡妙子 (90781617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 松阪諭 (00372665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YANO Ikuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 内田和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
22. 山崎晶

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 大石久史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 高橋智

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
25. 依馬正次

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 藤田潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
27. 羽渕友則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 柴崎貢志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 福本学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kojima Takahiro 小島 崇宏

KOJIMA Takahiro 小島 崇宏

Research Projects

Research Products

Co-Researchers

To elucidate the pathophysiological mechanism and explore the therapeutic target of underactive bladder / detrusor underactivity with focusing on the adenosine signaling pathwayOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膀胱がんにおける脂肪酸の質の意義の解明：脂肪酸伸長酵素ELOVL6に着目してOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Efficacy and toxicity of bladder instillation of anti-tumor peptide for inhibition of bladder tumor in miceOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

クラスターCTCに注目した泌尿器癌の分子基盤に基づいたバイオマーカーの開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Tumor-supporting mechanisms by inflammatory cells with somatic mutations

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel molecular characterization for urothelial cancer based on genetic and environmental factorsPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The establishment of a novel treatment in neurogenic bladder by the transplantation of the stem cells derived from the skeletal muscle stromaOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ASIC/ ENaC を介した膀胱癌の発癌と浸潤機序の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

抗酸菌表層糖脂質をリード化合物とする新規癌免疫治療法の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of BCG resistance mechanism by comprehensive analysis of immune environment and gene mutation in bladder cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of the tumor microenvironment in the development of urothelial carcinoma using animal model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The roles of RAC2-VAV1 signaling in oncogenesis and sarcomatoid differentiation of renal cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression of the oncoprotein gankyrin and phosphorylated retinoblastoma protein in human testis and testicular germ cell tumor

Principal Investigator

Project Period (FY)

Kojima Takahiro 小島崇宏

KOJIMA Takahiro 小島崇宏