Kubota Takuo 窪田拓生

Researcher Number	40629135
Other IDs
Affiliation (Current)	2025: 地方独立行政法人大阪府立病院機構大阪母子医療センター(研究所), 腎・代謝科, 主任部長 2025: 大阪大学, 大学院医学系研究科, 招へい教員
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 大学院医学系研究科, 准教授 2018 – 2021: 大阪大学, 医学系研究科, 講師 2017: 大阪大学, 医学系研究科, 助教 2015: 大阪大学, 医学(系)研究科(研究院), 助教 2013 – 2014: 大阪大学, 歯学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 小児内分泌学 / 骨代謝学 / Wntシグナル / 骨石灰化 / 小児科学 / リン / ピロリン酸 / 骨芽細胞分化 / 非古典的Wntシグナル / 間葉系幹細胞 … More / リン酸 / 骨代謝 / 小児骨代謝学 / 小児内分泌学　小児骨代謝学 / 小児科学、小児骨代謝学 / 転写因子 / 骨細胞 / 線維芽細胞 / くる病 / スクレロスチン / 骨粗鬆症 … More Except Principal Investigator くる病 / 骨疾患 / 代謝性骨疾患 / 骨形成 / 骨芽細胞 / FGF23 / リン代謝 / 骨折 / 遺伝子発現 / 骨系統疾患 / 低リン血症性くる病 / 骨形成不全症 / 骨細胞 Less

Wntシグナルをターゲットとした骨形成不全症の病態解析と治療法の開発Principal Investigator
- Principal Investigator
  
  窪田拓生
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka University
Analysis of dysfunction of osteocytes to reveal the targets of treatment in genetical bone diseases
- Principal Investigator
  
  Ozono Keiichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka University
Pyrophosphate regulatory mechanism in bone mineralizationPrincipal Investigator
- Principal Investigator
  
  Kubota Takuo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka University
Local phosphorus production system in bone mineralization: role of alkaline phosphatasePrincipal Investigator
- Principal Investigator
  
  Kubota Takuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
Elucidating mechanisms for coupling bone matrix formation with mineralizationPrincipal Investigator
- Principal Investigator
  
  Kubota Takuo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Association of trabecular bone score and bone mineral apparent density with the severity of bone fragility in children and adolescents with osteogenesis imperfecta: A cross-sectional study2023
- Author(s)
  Ohata Yasuhisa、Kitaoka Taichi、Ishimi Takeshi、Yamada Chieko、Nakano Yukako、Yamamoto Kenichi、Takeyari Shinji、Nakayama Hirofumi、Fujiwara Makoto、Kubota Takuo、Ozono Keiichi
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 8 Pages: e0290812-e0290812
- DOI
  10.1371/journal.pone.0290812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15940, KAKENHI-PROJECT-21H02881
[Journal Article] Self-Administration of Burosumab in Children and Adults with X-Linked Hypophosphataemia in Two Open-Label, Single-Arm Clinical Studies2023
- Author(s)
  Kubota Takuo、Namba Noriyuki、Tanaka Hiroyuki、Muroya Koji、Imanishi Yasuo、Takeuchi Yasuhiro、Kanematsu Masanori、Sun Wei、Seino Yoshiki、Ozono Keiichi
- Journal Title
  
  Advances in Therapy
  
  Volume: 40 Issue: 4 Pages: 1530-1545
- DOI
  10.1007/s12325-022-02412-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07797, KAKENHI-PROJECT-22K08315, KAKENHI-PROJECT-21H02881
[Journal Article] Safety and Efficacy of Burosumab in Pediatric Patients With X-Linked Hypophosphatemia: A Phase 3/4 Open-Label Trial2022
- Author(s)
  Namba Noriyuki、Kubota Takuo、Muroya Koji、Tanaka Hiroyuki、Kanematsu Masanori、Kojima Masahiro、Orihara Shunichiro、Kanda Hironori、Seino Yoshiki、Ozono Keiichi
- Journal Title
  
  Journal of the Endocrine Society
  
  Volume: 6 Issue: 5
- DOI
  10.1210/jendso/bvac021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08256, KAKENHI-PROJECT-21K07797
[Journal Article] Phosphate promotes osteogenic differentiation through non-canonical Wnt signaling pathway in human mesenchymal stem cells2022
- Author(s)
  Rui Shumin、Kubota Takuo、Ohata Yasuhisa、Yamamoto Kenichi、Fujiwara Makoto、Takeyari Shinji、Ozono Keiichi
- Journal Title
  
  Bone
  
  Volume: 164 Pages: 116525-116525
- DOI
  10.1016/j.bone.2022.116525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02881, KAKENHI-PROJECT-20K08256
[Journal Article] Burosumab treatment in adults with X-linked hypophosphataemia: 96-week patient-reported outcomes and ambulatory function from a randomised phase 3 trial and open-label extension2021
- Author(s)
  Briot Karine、Portale Anthony A、Brandi Maria Luisa、et al
- Journal Title
  
  RMD Open
  
  Volume: 7 Issue: 3 Pages: e001714-e001714
- DOI
  10.1136/rmdopen-2021-001714
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08683, KAKENHI-PROJECT-20K08256, KAKENHI-PROJECT-21K09293
[Journal Article] Neonatal cholestasis can be the first symptom of McCune-Albright syndrome: A case report2021
- Author(s)
  Satomura Yoshinori、Bessho Kazuhiko、Kitaoka Taichi、Takeyari Shinji、Ohata Yasuhisa、Kubota Takuo、Ozono Keiichi
- Journal Title
  
  World Journal of Clinical Pediatrics
  
  Volume: 10 Issue: 2 Pages: 7-14
- DOI
  10.5409/wjcp.v10.i2.7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08256, KAKENHI-PROJECT-18K15708
[Journal Article] Genotype-phenotype analysis, and assessment of the importance of the zinc-binding site in PHEX in Japanese patients with X-linked hypophosphatemic rickets using 3D structure modeling2021
- Author(s)
  Ishihara Y, Ohata Y, Takeyari S, Kitaoka T, Fujiwara M, Nakano Y, Yamamoto K, Yamada C, Yamamoto K, Michigami T, Mabe H, Yamaguchi T, Matsui K, Tamada I, Namba N, Yamamoto A, Etoh J, Kawaguchi A, Kosugi R, Ozono K, Kubota T
- Journal Title
  
  Bone
  
  Volume: 153 Pages: 116135-116135
- DOI
  10.1016/j.bone.2021.116135
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08256, KAKENHI-PROJECT-21K07797, KAKENHI-PROJECT-18K15708
[Journal Article] Alkaline phosphatase in pediatric patients with genu varum caused by vitamin D-deficient rickets2021
- Author(s)
  Mukai Masashi、Yamamoto Takehisa、Takeyari Shinji、Ohata Yasuhisa、Kitaoka Taichi、Kubota Takuo、Yamamoto Katsusuke、Kijima Eri、Hasegawa Yasuhiro、Michigami Toshimi、Ozono Keiichi
- Journal Title
  
  Endocr J
  
  Volume: 68 Issue: 7 Pages: 807-815
- DOI
  10.1507/endocrj.EJ20-0622
- NAID
  130008068265
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08256, KAKENHI-PROJECT-18K15708
[Journal Article] 4-Phenylbutyric acid enhances the mineralization of osteogenesis imperfecta iPSC-derived osteoblasts2021
- Author(s)
  Takeyari Shinji、Kubota Takuo、Ohata Yasuhisa、Fujiwara Makoto、Kitaoka Taichi、Taga Yuki、Mizuno Kazunori、Ozono Keiichi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100027-100027
- DOI
  10.1074/jbc.ra120.014709
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08256, KAKENHI-PROJECT-18K15708, KAKENHI-PROJECT-18H02780, KAKENHI-PROJECT-21H02881
[Journal Article] Clinical performance of a novel chemiluminescent enzyme immunoassay for FGF232021
- Author(s)
  Ito Nobuaki、Kubota Takuo、Kitanaka Sachiko、Fujiwara Ikuma、Adachi Masanori、Takeuchi Yasuhiro、Yamagami Hitomi、Kimura Takehide、Shinoda Tatsuya、Minagawa Masanori、Okazaki Ryo、Ozono Keiichi、Seino Yoshiki、Fukumoto Seiji
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: 39 Issue: 6 Pages: 1066-1075
- DOI
  10.1007/s00774-021-01250-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08256, KAKENHI-PROJECT-21K09293
[Journal Article] Clinical Practice Guidelines for Hypophosphatasia*2020
- Author(s)
  Michigami Toshimi、Ohata Yasuhisa、Fujiwara Makoto、Mochizuki Hiroshi、Adachi Masanori、Kitaoka Taichi、Kubota Takuo、Sawai Hideaki、Namba Noriyuki、Hasegawa Kosei、Fujiwara Ikuma、Ozono Keiichi
- Journal Title
  
  Clinical Pediatric Endocrinology
  
  Volume: 29 Issue: 1 Pages: 9-24
- DOI
  10.1297/cpe.29.9
- NAID
  130007783622
- ISSN
  0918-5739, 1347-7358
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10076, KAKENHI-PROJECT-18K15708
[Journal Article] Hypophosphatasia in Japan: ALPL Mutation Analysis in 98 Unrelated Patients2020
- Author(s)
  Michigami T, Tachikawa K, Yamazaki M, Kawai M, Kubota T, Ozono K
- Journal Title
  
  Calcif Tissue Int
  
  Volume: 106 Issue: 3 Pages: 221-231
- DOI
  10.1007/s00223-019-00626-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10076, KAKENHI-PROJECT-17K10092, KAKENHI-PROJECT-18K07866
[Journal Article] Incidence rate of vitamin D deficiency and FGF23 levels in 12- to 13-year-old adolescents in Japan2020
- Author(s)
  Koyama Satomi、Kubota Takuo、Naganuma Junko、Arisaka Osamu、Ozono Keiichi、Yoshihara Shigemi
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: Online Issue: 3 Pages: 456-462
- DOI
  10.1007/s00774-020-01173-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08256
[Journal Article] Long-term outcomes for Asian patients with X-linked hypophosphataemia: rationale and design of the SUNFLOWER longitudinal, observational cohort study2020
- Author(s)
  Kubota Takuo、Fukumoto Seiji、Cheong Hae Il、Michigami Toshimi、Namba Noriyuki、Ito Nobuaki、Tokunaga Shin、Gibbs Yoshimi、Ozono Keiichi
- Journal Title
  
  BMJ Open
  
  Volume: 10 Issue: 6 Pages: e036367-e036367
- DOI
  10.1136/bmjopen-2019-036367
- NAID
  120006953549
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08256, KAKENHI-PROJECT-18K07838
[Journal Article] Continued Beneficial Effects of Burosumab in Adults with X-Linked Hypophosphatemia: Results from a 24-Week Treatment Continuation Period After a 24-Week Double-Blind Placebo-Controlled Period2019
- Author(s)
  Portale AA, Carpenter TO, Brandi ML, Briot K, Cheong HI, Cohen-Solal M, Crowley R, Jan De Beur S, Eastell R, Imanishi Y, Imel EA, Ing S, Ito N, Javaid M, Kamenicky P, Keen R, Kubota T, et al.
- Journal Title
  
  Calcif Tissue Int
  
  Volume: 105 Issue: 3 Pages: 271-284
- DOI
  10.1007/s00223-019-00568-3
- Data Source
  KAKENHI-PROJECT-17K10076
[Journal Article] Genetic correction of induced pluripotent stem cells mediated by transcription activator-like effector nucleases targeting ALPL recovers enzyme activity and calcification in vitro2019
- Author(s)
  Nakano Chiho、Kitabatake Yasuji、Takeyari Shinji、Ohata Yasuhisa、Kubota Takuo、Taketani Ken、Kogo Mikihiko、Ozono Keiichi
- Journal Title
  
  Molecular Genetics and Metabolism
  
  Volume: 127 Issue: 2 Pages: 158-165
- DOI
  10.1016/j.ymgme.2019.05.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10076
[Journal Article] Japanese nationwide survey of hypophosphatasia reveals prominent differences in genetic and dental findings between odonto and non-odonto types2019
- Author(s)
  Okawa Rena、Kokomoto Kazuma、Kitaoka Taichi、Kubota Takuo、Watanabe Atsushi、Taketani Takeshi、Michigami Toshimi、Ozono Keiichi、Nakano Kazuhiko
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 10 Pages: e0222931-e0222931
- DOI
  10.1371/journal.pone.0222931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09854, KAKENHI-PROJECT-17K10076
[Journal Article] Comprehensive genetic analyses using targeted next-generation sequencing and genotype-phenotype correlations in 53 Japanese patients with osteogenesis imperfecta2019
- Author(s)
  Ohata Y., Takeyari S., Nakano Y., Kitaoka T., Nakayama H., Bizaoui V., Yamamoto K., Miyata K., Yamamoto K., Fujiwara M., Kubota T., Michigami T., Yamamoto K., Yamamoto T., Namba N., Ebina K., Yoshikawa H., Ozono K.
- Journal Title
  
  Osteoporosis International
  
  Volume: 30 Issue: 11 Pages: 2333-2342
- DOI
  10.1007/s00198-019-05076-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15708, KAKENHI-PROJECT-17K10076, KAKENHI-PROJECT-18H02780
[Journal Article] Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X‐Linked Hypophosphatemia: A Phase 3, Single‐Arm, International Trial2019
- Author(s)
  Insogna Karl L、Rauch Frank、Kamenicky Peter、Ito Nobuaki、Kubota Takuo、Nakamura Akie、Zhang Lin、Mealiffe Matt、San Martin Javier、Portale Anthony A
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: 34 Issue: 12 Pages: 2183-2191
- DOI
  10.1002/jbmr.3843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10076
[Journal Article] Successful induction of sclerostin in human-derived fibroblasts by 4 transcription factors and its regulation by parathyroid hormone, hypoxia, and prostaglandin E2.2016
- Author(s)
  Fujiwara M, Kubota T, Wang W, Ohata Y, Miura K, Kitaoka T, Okuzaki D, Namba N, Michigami T, Kitabatake Y, Ozono K.
- Journal Title
  
  Bone
  
  Volume: 85 Pages: 91-98
- DOI
  10.1016/j.bone.2016.01.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860858
[Journal Article] Two Japanese familial cases of Caffey disease with and without the common COL1A1 mutation and normal bone density, and review of the literature.2014
- Author(s)
  Taichi Kitaoka, Yoko Miyoshi, Noriyuki Namba, Kohji Miura, Takuo Kubota, Yasuhisa Ohata, Makoto Fujiwara, Masaki Takagi, Tomonobu Hasegawa, Harald Jüppner, Keiichi Ozono
- Journal Title
  
  European Journal of Pediatrics
  
  Volume: [Epub ahead of print] Issue: 6 Pages: 1-6
- DOI
  10.1007/s00431-013-2252-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461548, KAKENHI-PROJECT-25860858
[Journal Article] Serum Fibroblast Growth Factor 23 Is a Useful Marker to Distinguish Vitamin D-Deficient Rickets from Hypophosphatemic Rickets.2014
- Author(s)
  Kubota T, Kitaoka T, Miura K, Fujiwara M, Ohata Y, Miyoshi Y, Yamamoto K, Takeyari S, Yamamoto T, Namba N, Ozono K.
- Journal Title
  
  Hormone Research in Paediatrics
  
  Volume: [Epub ahead of print] Issue: 4 Pages: 1-7
- DOI
  10.1159/000357142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461548, KAKENHI-PROJECT-25860858
[Journal Article] Restoration of parathyroid function after change of phosphate binder from calcium carbonate to lanthanum carbonate in hemodialysis patients with suppressed serum parathyroid hormone.2014
- Author(s)
  Inaba M, Okuno S, Nagayama H, Yamada S, Ishimura E, Imanishi Y, Shoji S
- Journal Title
  
  J Ren Nutr
  
  Volume: 25 Pages: 242-246
- DOI
  10.1016/j.bone.2014.06.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591353, KAKENHI-PROJECT-25461548, KAKENHI-PROJECT-25860858
[Presentation] Clinical Features of FGF23-Related Hypophosphatemic Rickets/Osteomalacia: A Multicenter National Survey in Japan2023
- Author(s)
  Makoto Fujiwara, Taichi Kitaoka, Yasuhisa Ohata, Hirofumi Nakayama, Yukako Nakano, Kenichi Yamamoto, Hiroyuki Saito, Chieko Yamada, Takeshi Ishimi, Ikumi Ueda, Tatsuya Nakamichi, Rieko Takatani, Masanori Minagawa, Inoue Daisuke, Yasuhiro Takeuchi, Seiji Fukumoto, Takashi Akamizu, Keiichi Ozono, and Takuo Kubota
- Organizer
  ASBMR 2023 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] 当科XLH患者に対するブロスマブ治療長期効果の検討2023
- Author(s)
  大幡泰久, 山田知絵子, 中野由佳子, 山本賢一, 武鑓真司, 藤原誠, 北岡太一, 窪田拓生, 大薗恵一
- Organizer
  第96回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] 本邦における FGF23 関連低リン血症性くる病・骨軟化症患者の臨床像の解析2023
- Author(s)
  藤原誠, 石見壮史, 山田知絵子, 武鑓真司, 山本賢一, 中野由佳子, 中山尋文, 大幡泰久, 北岡太一, 窪田拓生, 大薗恵一
- Organizer
  第41回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] 骨形成不全症の新規モデルマウス2022
- Author(s)
  武鑓真司, 大幡泰久, 藤原誠, 北岡太一, 窪田拓生, 大薗恵一
- Organizer
  第55回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] 小児骨形成不全症におけるビスホスホネート治療および体重は血清スクレロスチン値に影響する2022
- Author(s)
  藤原誠, 北岡太一, 石見壮史, 山田知絵子, 武鑓真司, 山本賢一, 中野由佳子, 中山尋文, 大幡泰久, 窪田拓生, 大薗恵一
- Organizer
  第95回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] Col1a1G643S/+ mouse model of osteogenesis imperfecta2022
- Author(s)
  Shinji Takeyari, Yasuhisa Ohata, Makoto Fujiwara, Taichi Kitaoka, Takuo Kubota, Keiichi Ozono
- Organizer
  ASBMR 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] Genotype-phenotype analysis, and assessment of the importance of the zinc-binding site in PHEX in Japanese patients with X-linked hypophosphatemic rickets using 3D structure modeling.2021
- Author(s)
  Ohata Y, Ishihara Y, Takeyari S, Kubota T, Ozono K
- Organizer
  American Society for Bone and Mineral Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] ビタミンD 抵抗性くる病・骨軟化症のレジストリ2021
- Author(s)
  窪田拓生
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] くる病診断と線維芽細胞増殖因子23（FGF23）測定の意義2021
- Author(s)
  窪田拓生
- Organizer
  第31回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] 小児疾患の疾患モデルと新規治療法2021
- Author(s)
  窪田拓生
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] Genotype-phenotype analysis, and assessment of the importance of the zinc-binding site in PHEX in Japanese patients with X-linked hypophosphatemic rickets using 3D structure modeling.2021
- Author(s)
  Ishihara Y, Ohata Y, Takeyari S, Kitaoka T, Fujiwara M, Nakano Y, Yamamoto K, Yamada C, Yamamoto K, Michigami T, Mabe H, Yamaguchi T, Matsui K, Tamada I, Namba N, Yamamoto A, Etoh J, Kawaguchi A, Kosugi R, Ozono K, Kubota T
- Organizer
  2021 Annual Meeting of the American Society for Bone and Mineral Research
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] 低リン血症性ビタミンD抵抗性くる病／骨軟化症の多施設研究と疾患レジストリ2021
- Author(s)
  窪田拓生, 中山尋文, 高谷里依子, 皆川真規, 井上大輔, 竹内靖博, 福本誠二, 大薗恵一
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] FGF23関連低リン血症性くる病・骨軟化症の治療薬の進歩2021
- Author(s)
  窪田拓生
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] Clinical, Biochemical and Genetic Study in Patients with Odontohypophosphatasia in Japan2020
- Author(s)
  Kubota T, Ohata Y, Ishihara Y, Fujiwara M, Takeyari S, Yamamoto K, Nakano Y, Kitaoka T, Nakayama H, Yamada C, Ishimi T, Okawa R, Nakano K, Akiyama T, Kakimoto H, Araki S, Sano S, Ogata T, Ozono K.
- Organizer
  ASBMR　2020　Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] 小児とビタミンD2020
- Author(s)
  窪田拓生
- Organizer
  第93回　日本内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] 家族歴を有し遺伝子診断されたX連鎖性低リン血症性骨軟化症の1例2020
- Author(s)
  山田知絵子、窪田拓生、大幡泰久、北岡太一、大薗恵一
- Organizer
  臨床内分泌代謝UPDATE2020
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] ビタミンD代謝と疾患2020
- Author(s)
  窪田拓生
- Organizer
  2020年　日本小児内分泌学会特別学術集会
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] パミドロン酸からゾレドロン酸に投与変更した小児骨疾患の検討2020
- Author(s)
  中山尋文, 山田知絵子, 宮田京, 中野由佳子, 山本賢一, 武鑓真司, 大幡泰久, 藤原誠北岡太一, 窪田拓生, 大薗恵一
- Organizer
  第93回　日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] 低リン血症性ビタミンD 抵抗性くる病／骨軟化症のアンケート調査と患者レジストリ2020
- Author(s)
  窪田拓生, 中山尋文, 高谷里依子, 皆川真規, 井上大輔, 竹内靖博，福本誠二, 大薗恵一
- Organizer
  第38回　日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] 成長曲線から見た骨疾患2020
- Author(s)
  窪田拓生
- Organizer
  第123回　日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] 骨系統疾患の診療＜小児科の立場から＞2020
- Author(s)
  窪田拓生
- Organizer
  第6回　日本産科婦人科遺伝診療学会
- Data Source
  KAKENHI-PROJECT-20K08256
[Presentation] 歯限局型低ホスファターゼ症の生化学的・遺伝学的検討2019
- Author(s)
  窪田拓生, 大幡泰久, 石原康貴, 藤原　誠, 武鑓真司, 山本賢一, 中野由佳子, 中山尋文, 北岡太一, 大薗恵一
- Organizer
  第37回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10076
[Presentation] Biochemical and genetic analysis in patients with odontohypophosphatasia in Japan2019
- Author(s)
  Kubota T, Ohata Y, Ishihara Y, Fujiwara M, Takeyari S, Yamamoto K, Nakano Y, Miyata K, Nakayama H, Kitaoka T, Okawa R, Nakano K, Akiyama T, Ozono K
- Organizer
  9th International Conference on Children's Bone Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10076
[Presentation] くる病2019
- Author(s)
  窪田拓生
- Organizer
  第92回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10076
[Presentation] 日本人低ホスファターゼ症患者52例のベースラインの検討　―ALP酵素補充療法特定使用成績調査より―2019
- Author(s)
  窪田拓生, 藤原幾磨, 道上敏美, 渡邉　淳, 難波範行, 鬼頭浩史, 室月　淳, 杉山裕一朗, 仲野和彦, 笹谷晴恵, 長谷川航, 別所友子, 澤井英明, 大薗恵一
- Organizer
  第53回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10076
[Presentation] Mutation analysis of the PHEX gene and genotype-phenotype correlation in 37Japanese patients X-linked hypophosphatemic rickets2019
- Author(s)
  Ohata Y, Kubota T, Takeyari S, Kitaoaka T, Nakano Y, Miyata K, Yamada C, Ozono K, Ishihara Y, Nakayama H, Yamamoto K, Fujiwara M, Yamamoto K, Michigami T, Mabe H, Yamaguchi T, Matsui K, Tamada I, Namba N, Yamamoto A, Etoh J, Kawaguchi A
- Organizer
  2019 Annual Meeting of American Society for Bone and Mineral Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10076
[Presentation] 低リン血症性疾患の病態と診断～FGF23測定の有用性～2019
- Author(s)
  窪田拓生
- Organizer
  第37回日本骨代謝学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10076
[Presentation] 低ホスファターゼ症患者由来iPS細胞におけるTALENを用いた遺伝子変異修復2018
- Author(s)
  中野知帆、北畠康司、武鑓真司、大幡泰久、窪田拓生、竹谷健、古郷幹彦、大薗恵一
- Organizer
  第52回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10076
[Presentation] X連鎖性低リン血症性くる病に併存するhypovitaminosis Dの検討2018
- Author(s)
  中山尋文・宮田京・中野由佳子・山本賢一・武鑓真司・大幡泰久・北岡太一・窪田拓生・大薗恵一・道上敏美・山本勝輔
- Organizer
  第91回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K10076
[Presentation] X連鎖性低リン血症性くる病患者における血清FGF23濃度と関連するパラメータの検討2017
- Author(s)
  5.窪田拓生、山本景子、宮田京、武鑓真司、山本賢一、中山尋文、藤原誠、北岡太一、高桑聖、大薗恵一
- Organizer
  第90回日本内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10076
[Presentation] スクレロスチンの発現は転写因子ATF3, KLF4, PAX4, SP7の導入によりヒト線維芽細胞で誘導され、 PTH及び低酸素培養による制御を受ける2015
- Author(s)
  藤原　誠, 大幡泰久, 北岡太一，窪田拓生, 北畠康司, 難波範行, 道上敏, 大薗　恵一
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-25860858
[Presentation] Defined Sets of Transcription Factors Induce the Expression of Functional Sclerostin in Human Dermal Fibroblasts and Its Expression Responds to Parathyroid Hormone, Hypoxia and Prostaglandin E2.2015
- Author(s)
  Makoto Fujiwara, Wei Wang, Taichi Kitaoka，Takuo Kubota, Yasuji Kitabatake, Noriyuki Namba，Toshimi Michigami, Keiichi Ozono
- Organizer
  Annual Meeting of American Society for Bone and Mineral Research 2015
- Place of Presentation
  Seattle, WA, USA
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860858
[Presentation] ヒト線維芽細胞にスクレロスチンを発現させるために必要な転写因子の同定
- Author(s)
  藤原誠，大幡泰久，三浦弘司，北岡太一，窪田拓生，北畠康司，難波範行，道上敏美，大薗恵一
- Organizer
  第32回　日本骨代謝学会学術集会
- Place of Presentation
  大阪市
- Year and Date
  2014-07-24 – 2014-07-26
- Data Source
  KAKENHI-PROJECT-25860858
[Presentation] FAM20C遺伝子変異による低リン血症性骨軟化症の１例
- Author(s)
  武鑓真司，山本威久，木下祐加，福本誠二，道上敏美，長谷川高誠，北岡太一，窪田拓生，今西康雄，下辻常介，大薗恵一
- Organizer
  第87回　日本内分泌学会学術総会
- Place of Presentation
  福岡市
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25860858
[Presentation] Sclerostin Expression can be Induced by Enforced Expression of Defined Transcription Factors in Human Fibroblasts
- Author(s)
  Fujiwara M，Wang W，Ohata Y，Miura K，Kitaoka T，Kubota T，Kitabatake Y，Namba N，Michigami T，Ozono K
- Organizer
  Annual Meeting of American Society for Bone and Mineral Research 2014
- Place of Presentation
  Houston, TX, USA
- Year and Date
  2014-09-12 – 2014-09-15
- Data Source
  KAKENHI-PROJECT-25860858

1. 道上敏美 (00301804)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. Fujiwara Makoto (50625697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. Ozono Keiichi (20270770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. 大幡泰久 (20805460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. 岡田随象 (70727411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAMBA Noriyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. INABA Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 北岡太一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 大川玲奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 古々本一馬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 今西康雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kubota Takuo 窪田 拓生

Research Projects

Research Products

Co-Researchers

Wntシグナルをターゲットとした骨形成不全症の病態解析と治療法の開発Principal Investigator

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Analysis of dysfunction of osteocytes to reveal the targets of treatment in genetical bone diseases

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Pyrophosphate regulatory mechanism in bone mineralizationPrincipal Investigator

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Local phosphorus production system in bone mineralization: role of alkaline phosphatasePrincipal Investigator

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Elucidating mechanisms for coupling bone matrix formation with mineralizationPrincipal Investigator

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[Journal Article] Association of trabecular bone score and bone mineral apparent density with the severity of bone fragility in children and adolescents with osteogenesis imperfecta: A cross-sectional study2023

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[Journal Article] Self-Administration of Burosumab in Children and Adults with X-Linked Hypophosphataemia in Two Open-Label, Single-Arm Clinical Studies2023

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[Journal Article] Safety and Efficacy of Burosumab in Pediatric Patients With X-Linked Hypophosphatemia: A Phase 3/4 Open-Label Trial2022

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[Journal Article] Phosphate promotes osteogenic differentiation through non-canonical Wnt signaling pathway in human mesenchymal stem cells2022

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[Journal Article] Burosumab treatment in adults with X-linked hypophosphataemia: 96-week patient-reported outcomes and ambulatory function from a randomised phase 3 trial and open-label extension2021

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[Journal Article] Neonatal cholestasis can be the first symptom of McCune-Albright syndrome: A case report2021

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[Journal Article] Genotype-phenotype analysis, and assessment of the importance of the zinc-binding site in PHEX in Japanese patients with X-linked hypophosphatemic rickets using 3D structure modeling2021

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[Journal Article] Alkaline phosphatase in pediatric patients with genu varum caused by vitamin D-deficient rickets2021

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[Journal Article] 4-Phenylbutyric acid enhances the mineralization of osteogenesis imperfecta iPSC-derived osteoblasts2021

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Kubota Takuo 窪田拓生