Machiyama Hiroaki 町山裕亮

Researcher Number	40704606
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2017 – 2024: 東京医科大学, 医学部, 講師 2016: 東京医科大学, 医学部, 助教 2015: 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤)
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 43040:Biophysics-related / Immunology Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics
Keywords	Principal Investigator シグナル伝達 / 分子イメージング / T細胞 / CAR-T細胞 / 細胞膜ダイナミクス / 抗原認識 / T細胞シグナル / 腫瘍免疫 / 制御性Ｔ細胞 / 数理モデル … More / ライブセルイメージング / 単一細胞操作 / 抗原特異性 / 蛍光イメージング / 1細胞操作 / カルシウムイメージング / 一細胞操作 / 獲得免疫 … More Except Principal Investigator キメラ抗原受容体 / シグナル伝達 / 分子イメージング / 細胞療法 / イメージング / 免疫チェックポイント / 免疫シナプス / マイクロクラスター / シグナル伝達分子 / CAR-T細胞 / ICOS / 2B4 / T細胞補助刺激受容体 / T細胞補助シグナル / T細胞疲弊 / 免疫学 / キメラ抗原受容体T細胞 / T細胞 / がん免疫 Less

Functions of TCR and coreceptors as regulating factors for T cell activation in CAR-T cell therapy.Principal Investigator
- Principal Investigator
  
  町山裕亮
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
Development of the basis of the crosstalk between T cell costimulatory receptors and chimeric antigen receptors
- Principal Investigator
  
  横須賀忠
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
Molecualr imaging for development of chimeric antigen receptors (CARs) resistant to T cell exhaustion
- Principal Investigator
  
  Yokosuka Tadashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
Spatiotemporal mechanism in T cell signaling regulated by cell membrane dynamicsPrincipal Investigator
- Principal Investigator
  
  Machiyama Hiroaki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Tokyo Medical University
Basic research for the development of a novel CAR-adaptor T cells by an advanced imaging system
- Principal Investigator
  
  Yokosuka Tadashi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokyo Medical University
Regulation of antigen-specific immune responses by stoichiometric activated individual CD4 T cellsPrincipal Investigator
- Principal Investigator
  
  Machiyama Hiroaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical University
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] Basic Immunology and Its Clinical Application2024
- Author(s)
  Nishi Wataru, Ei Wakamatsu, Hiroaki Machiyama, Ryohei Matsushima, Yosuke Yoshida, Tetsushi Nishikawa, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Makoto Suzuki, Tadashi Yokosuka
- Total Pages
  258
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23K27466
[Book] Precision Medicine2022
- Author(s)
  横須賀忠、若松英、西嶋仁、竹内新、町山裕亮
- Total Pages
  90
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-20H03536
[Book] 腫瘍内科2022
- Author(s)
  横須賀忠、若松英、西嶋仁、西航、松島遼平、西川哲史、町山裕亮、竹内新
- Total Pages
  139
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-20H03536
[Book] 「膜タンパク質工学ハンドブック」第7章第2節免疫チェックポイント受容体PD-1とCTLA-42020
- Author(s)
  横須賀忠、若松英、町山裕亮
- Total Pages
  624
- Publisher
  株NTS
- ISBN
  9784860435370
- Data Source
  KAKENHI-PROJECT-17H03600
[Book] 実験医学増刊号「新規の創薬モダリティ　細胞医薬」2020
- Author(s)
  横須賀忠, 若松英, 西嶋仁, 竹原朋宏, 西航, 塚本昌子, 町山裕亮
- Total Pages
  241
- Publisher
  羊土社
- ISBN
  9784260042383
- Data Source
  KAKENHI-PROJECT-20H03536
[Book] 実験医学増刊号「新・腫瘍免疫学」免疫チェックポイント分子の分子作用機序2019
- Author(s)
  横須賀忠、若松英、秦喜久美、竹原朋宏、西航、矢那瀬紀子、町山裕亮
- Total Pages
  268
- Publisher
  羊土社
- ISBN
  9784758103817
- Data Source
  KAKENHI-PROJECT-17H03600
[Book] 実験医学すべてはここから始まった、CTLA-42018
- Author(s)
  横須賀忠、若松英、古畑昌枝、豊田博子、秦喜久美、矢那瀬紀子、町山裕亮
- Total Pages
  138
- Publisher
  羊土社
- ISBN
- Data Source
  KAKENHI-PROJECT-17H03600
[Book] 臨床免疫・アレルギー科　分子イメージングから考察した免疫チェックポイント分子のT細胞抑制機構2018
- Author(s)
  横須賀忠、若松英、古畑昌枝、豊田博子、秦喜久美、矢那瀬紀子、町山裕亮
- Total Pages
  119
- Publisher
  科学評論社
- ISBN
- Data Source
  KAKENHI-PROJECT-17H03600
[Book] 東邦医学会雑誌分子イメージングが拓く免疫チェックポイント受容体のT細胞活性化制御機構2018
- Author(s)
  横須賀忠、若松英、秦喜久美、矢那瀬紀子、竹原朋宏、町山裕亮
- Total Pages
  22
- Publisher
  東邦医学会雑誌編集事務局
- ISBN
- Data Source
  KAKENHI-PROJECT-17H03600
[Book] 生物物理2018
- Author(s)
  横須賀忠、若松英、矢那瀬紀子、秦喜久美、町山裕亮
- Total Pages
  64
- Publisher
  日本生物物理学会
- ISBN
- Data Source
  KAKENHI-PROJECT-17H03600
[Journal Article] Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters2023
- Author(s)
  Nishi Wataru、Wakamatsu Ei、Machiyama Hiroaki、Matsushima Ryohei、Saito Kensho、Yoshida Yosuke、Nishikawa Tetsushi、Takehara Tomohiro、Toyota Hiroko、Furuhata Masae、Nishijima Hitoshi、Takeuchi Arata、Azuma Miyuki、Suzuki Makoto、Yokosuka Tadashi
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1-16
- DOI
  10.1038/s41467-023-38512-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07124, KAKENHI-PROJECT-22K07261, KAKENHI-PROJECT-22K08487, KAKENHI-PUBLICLY-23H04790, KAKENHI-PROJECT-23K27466
[Journal Article] PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment2021
- Author(s)
  Tomohiro Takehara, Ei Wakamatsu, Hiroaki Machiyama, Wataru Nishi, Katsura Emoto, Miyuki Azuma, Kenzo Soejima, Koichi Fukunaga, Tadashi Yokosuka
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1-12
- DOI
  10.1038/s42003-021-02111-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22545, KAKENHI-PROJECT-20J10564, KAKENHI-PROJECT-18K06165, KAKENHI-ORGANIZER-16H06495, KAKENHI-WRAPUP-21H00461, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-19K07718, KAKENHI-INTERNATIONAL-16K21731, KAKENHI-PROJECT-20H03536
[Journal Article] Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance2019
- Author(s)
  Yamaguchi Tomoyuki、Teraguchi Shunsuke、Furusawa Chikara、Machiyama Hiroaki、Watanabe Tomonobu M、Fujita Hideaki、Sakaguchi Shimon、Yanagida Toshio
- Journal Title
  
  International Immunology
  
  Volume: 31 Issue: 11 Pages: 743-753
- DOI
  10.1093/intimm/dxz043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06165, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-15H05746
[Journal Article] The use of a genetically encoded molecular crowding sensor in various biological phenomena2017
- Author(s)
  Hiroaki Machiyama, Takamitsu J. Morikawa, Kazuko Okamoto, Tomonobu M. Watanabe, Hideaki Fujita
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 14 Issue: 0 Pages: 119-125
- DOI
  10.2142/biophysico.14.0_119
- NAID
  130005987549
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03600, KAKENHI-PROJECT-15K19128
[Journal Article] Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells.2017
- Author(s)
  Okada M, Chikuma S et al.
- Journal Title
  
  Cell Reports
  
  Volume: 20 Issue: 5 Pages: 1017-1028
- DOI
  10.1016/j.celrep.2017.07.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K15451, KAKENHI-INTERNATIONAL-16K21731, KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06501, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H03600, KAKENHI-PROJECT-17H07088, KAKENHI-PROJECT-15J07566, KAKENHI-PROJECT-15K19128
[Journal Article] A novel c-Src recruitment pathway from the cytosol to focal adhesions2017
- Author(s)
  H. Machiyama, Yamaguchi T, Watanabe TM, Fujita H
- Journal Title
  
  FEBS Lett.
  
  Volume: 591 Issue: 13 Pages: 1940-1946
- DOI
  10.1002/1873-3468.12696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26291028, KAKENHI-PROJECT-17H03600, KAKENHI-PROJECT-15K19128
[Journal Article] Non-label immune cell state prediction using Raman spectroscopy2016
- Author(s)
  Taro Ichimura, Liang-da Chiu, Katsumasa Fujita, Hiroaki Machiyama, Tomoyuki Yamaguchi, Tomonobu M. Watanabe, and Hideaki Fujita
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 37562-37562
- DOI
  10.1038/srep37562
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01439, KAKENHI-PROJECT-26286063, KAKENHI-PROJECT-15K20950, KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-16K14717, KAKENHI-PROJECT-15K19128, KAKENHI-PROJECT-26291028
[Presentation] PD-1-mediated suppression of CAR-T cells via CAR signalosomes colocalized by PD-12024
- Author(s)
  Yosuke Yoshida、Hiroaki Machiyama、Ei Wakamatsu、Arata Takeuchi、Hitoshi Nishijima、Tetsushi Nishikawa、Ryohei Matsushima、Masae Furuhata、Hiroko Toyota、Mamonkin Maksim、Brenner Malcolm K、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] 超解像イメージングが解明する免疫チェックポイント阻害療法の分子メカニズム2024
- Author(s)
  横須賀忠、西航、松島遼平、西川哲史、吉田洋輔、竹原朋宏、西嶋仁、町山裕亮、若松英、竹内新
- Organizer
  第51回日本集中治療医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] CD4/CD8 coreceptor binding to MHCs positively regulate CAR-T cell response via translocation of Lck into CAR microclusters2024
- Author(s)
  Hiroaki Machiyama、Ei Wakamatsu、Arata Takeuchi、Hitoshi Nishijima、Tetsushi Nishikawa、Ryohei Matsushima、Yosuke Yoshida、Masae Furuhata、Hiroko Toyota、Mamonkin Maksim、Brenner Malcolm K、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] c-SMAC formation in double positive T cells functions as a checkpoint in thymic selection2024
- Author(s)
  Hitoshi Nishijima、Ei Wakamatsu、Hiroaki Machiyama、Arata Takeuchi、Tetsushi Nishikawa、Yosuke Yoshida、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] Comparison of linear and parallel co-stimulatory signaling via CD28 in the activation of Chimeric Antigen Receptor T Cells2024
- Author(s)
  Tetsushi Nishikawa、Arata Takeuchi、Hiroaki Machiyama、Ei Wakamatsu、Hitoshi Nishijima、Masae Furuhata、Hiroko Toyota、Nishi Wataru、Ryohei Matsushima、Yosuke Yoshida、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] Fine tuning of T cell activation by multistep regulation of CD6 and its ligand CD1662024
- Author(s)
  Arata Takeuchi、Tetsushi Nishikawa、Hiroaki Machiyama、Ei Wakamatsu、Hitoshi Nishijima、Masae Furuhata、Hiroko Toyota、Ryohei Matsushima、Yosuke Yoshida、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] Super-resolution imaging elucidates the molecular mechanism of CAR-T cells and ICI immunotherapy2023
- Author(s)
  横須賀忠、若松英、西嶋仁、竹内新、松島遼平、西航、西川哲史、吉田洋輔、Maksim Mamokin、Malcolm K Brenner、町山裕亮
- Organizer
  第85回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] 分子イメージングシステムを用いた補助刺激受容体2B4のT細胞におけるスイッチング機構の解明とCAR-T細胞への応用2023
- Author(s)
  松島遼平、若松英、齋藤顕昇、吉田洋輔、西川哲史、西航、豊田博子、古畑昌枝、町山裕亮、西嶋仁、竹内新、鈴木実、横須賀忠
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] 免疫チェックポイント阻害剤の効果に影響するヒトPD-1変異の解析2023
- Author(s)
  西航、若松英、町山裕亮、松島遼平、西川哲史、吉田洋輔、豊田博子、古畑昌枝、西嶋仁、竹内新、池田公英、鈴木実、横須賀忠
- Organizer
  第64回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] キメラ抗原受容体CAR-T細胞の初期の活性化と細胞応答におけるLckの分子動態と共受容体の関与2023
- Author(s)
  町山裕亮、若松英、西嶋仁、竹内新、横須賀忠
- Organizer
  第32回京都T細胞カンファレンス
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] ヒトPD-1マイクロクラスターの1分子イメージングを用いた治療用抗PD-1/PD-L1抗体の機能評価の研究2023
- Author(s)
  横須賀忠、西航、若松英、町山裕亮、松島遼平、吉田洋輔、西川哲史、竹原朋宏、西嶋仁、竹内新、東みゆき、鈴木実
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] キメラ抗原受容体CAR-T細胞の初期の活性化と細胞応答性におけるLckの分子動態とCD8-MHC相互作用の寄与2022
- Author(s)
  町山裕亮、若松英、西嶋仁、竹内新、横須賀忠、Maksim Mamonkin, Malcolm K Brenner
- Organizer
  第31回 Kyoto T Cell Conference
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] 超解像イメージングが解明するCAR-T細胞療法とICI療法のシグナル伝達2022
- Author(s)
  横須賀忠、若松英、竹内新、町山裕亮
- Organizer
  第45回日本造血・免疫細胞療法学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Dynamics of the PI3K signaling pathway through the cytosolic domain of ICOS2022
- Author(s)
  Ei Wakamatsu, Hiroaki Machiyama, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Tadashi Yokosuka
- Organizer
  第51回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Extrinsic and intrinsic inhibition of T cell response by co-inhibitory receptors, TIGIT and CD962022
- Author(s)
  Ann Hattori, Ei Wakamatsu, Hiroaki Machiyama, Ryuji Hashimoto, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Tadashi Yokosuka
- Organizer
  第51回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Evaluation of therapeutic PD-1 antibodies by a newly established imaging system for human PD-1 microclusters2022
- Author(s)
  Wataru Nishi，Ei Wakamatsu、Ryohei Matsushima、Tetsushi Nishikawa, Tomohiro Takehara, Hiroaki Machiyama, Hitoshi Nishijima, Arata Takeuchi, Miyuki Azuma, Makoto Suzuki, and Tadashi Yokosuka
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] CAR-T細胞活性化における共受容体CD8の役割2022
- Author(s)
  町山裕亮, 若松英, Mamonkin Maksim, Brenner K. Malcom, 横須賀忠
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Binding of the CD4/CD8 coreceptor to an MHC molecule positively modulates CAR-T cell response2022
- Author(s)
  Hiroaki Machiyama, Ei Wakamatsu, Arata Takeuchi, Hitoshi Nishijima, Masae Furuhata, Hiroko Toyota, Maksim Mamonkin, Malcolm K Brenner, Tadashi Yokosuka
- Organizer
  第51回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] リンパ節の皮髄境界面は新規の間質細胞サブセットで構成され、リンパ球に抗原認識の場を提供する2022
- Author(s)
  竹内新、神田泰洋、小澤まどか、町山裕亮、横須賀忠、片貝智哉
- Organizer
  第31回 Kyoto T Cell Conference
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Human T cells illustrate TCR microclusters by triggering with bispecific antibodies, blinatumomab2021
- Author(s)
  Hitoshi Nishijima, Arata Takeuchi, Ei Wakamatsu, Wataru Nishi, Hiroaki Machiyama, Tadashi Yokosuka
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] LAG-3発現CD4+ T細胞はMHC class IIのトロゴサイトーシスを介して間接的にCD4+ T細胞の活性化を抑制する2021
- Author(s)
  若松英、町山裕亮、豊田博子、古畑昌枝、西嶋仁、竹内新、横須賀忠
- Organizer
  第30回 Kyoto T Cell Conference
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] The kinase Lck activate CAR-T cells independently upon co-receptor association.2021
- Author(s)
  Hiroaki Machiyama, Ei Wakamatsu, Masae Furuhata, Hiroko Toyota, Mamonkin Maksim, Brenner Malcolm K, Tadashi Yokosuka
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] Establishment of a molecular imaging system to evaluate the T cell exhaustion releasing function of human PD-1/PD-L1 antibodies.2021
- Author(s)
  Nishi Wataru, Ei Wakamatsu, Nishiakwa Tetsuji, Takehara Tomohiro, Toyoda Hiroko, Furuhata Masae, Hiroaki Machiyama, Nishijima Hitoshi, Azuma Miyuki, Suzuki Makoto, Tadashi Yokosuka
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] The kinase Lck activate CAR-T cells independently upon co-receptor association.2021
- Author(s)
  Hiroaki Machiyama, Ei Wakamatsu, Masae Furuhata, Hiroko Toyota, Mamonkin Maksim, Brenner Malcolm K, Tadashi Yokosuka
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] 一分子動態解析法を用いたT細胞活性化におけるシグナルソームの時空間的制御機構の解明　～簡単・簡便なキメラ抗原受容体CAR-T細胞療法に向けて～2021
- Author(s)
  町山裕亮
- Organizer
  第36回日本DDS学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] CAR-T細胞の抗原認識と活性化を担うCARマイクロクラスターの分子イメージング解析2021
- Author(s)
  横須賀忠、若松英、西嶋仁、竹内新、竹原朋宏、西航、西川哲史、Maksim Mamokin、Malcolm K. Brenner、町山裕亮
- Organizer
  第25回日本がん免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] CAR-T 細胞の抗原認識と活性化を担う CAR マイクロクラスターの分子イメージング解析2021
- Author(s)
  横須賀忠、若松英、西嶋仁、竹内新、竹原朋宏、西航、西川哲史、モマキンマクシム、ブレンナーマルコム、町山裕亮
- Organizer
  第25回日本がん免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] キメラ抗原受容体（CAR）-T細胞活性化と細胞骨格、Role of cytoskeleton in Chimeric antigen receptor (CAR)-T cell therapy2021
- Author(s)
  町山裕亮
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] LAG-3-mediated trogocytosis of MHC class II indirectly regulates CD4+ T cell activation2021
- Author(s)
  Ei Wakamatsu, Hiroaki Machiyama, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Tadashi Yokosuka
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] 分子イメージングによるT細胞活性化機構の解明とがん免疫2021
- Author(s)
  横須賀忠、若松英、西嶋仁、竹内新、竹原朋宏、西航、西川哲史、Maksim Mamokin、Malcolm K. Brenner、町山裕亮
- Organizer
  第61回日本リンパ網内系学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Visualizing of neo-self phenomena in Chimeric antigen receptor (CAR)-T cells.2021
- Author(s)
  町山裕亮
- Organizer
  第58回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] Role of cytoskeleton in Chimeric antigen receptor (CAR)-T cell therapy.2020
- Author(s)
  Machiyama H, Wakamatsu E, Yokosuka T
- Organizer
  The 43rd Annual Meeting of Molecular Biology Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] 一分子動態解析法を用いたT細胞活性化におけるシグナルソームの時空間的制御機構の解明～簡単・簡便なキメラ抗原受容体CAR-T細胞療法に向けて～2020
- Author(s)
  町山裕亮, 若松英, 矢那瀬紀子, 横須賀忠
- Organizer
  第36回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Visualizing of neo-self phenomena in chimeric antigen receptor (CAR)-T cells.2020
- Author(s)
  町山裕亮, 若松英, 秦喜久美, 矢那瀬紀子, 竹原朋宏, 西航, Mamonkin M, Brenner MK, 横須賀忠
- Organizer
  第58回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] 分子イメージングによるPD-1ーPD-L2を介するT細胞抑制機構の解明2020
- Author(s)
  竹原朋宏, 若松英, 町山裕亮, 副島研造, 福永興壱, 横須賀忠
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Different requirement of the coreceptors CD4 and CD8 for initiation of T cell activation.2019
- Author(s)
  Hiroaki Machiyama, Ei Wakamatsu, Kikumi Hata, Noriko Yanase, Masae Furuhata, Hiroko Toyota, Tadashi Yokosuka
- Organizer
  The 48th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] Different requirement of the coreceptors CD4 and CD8 for initiation of T cell activation.2019
- Author(s)
  Machiyama H Wakamatsu E, Hata K, Yanase N, Furuhata M, Toyota H, Yokosuka T
- Organizer
  第48回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] CARマイクロクラスターによる腫瘍抗原の認識とCAR-T細胞活性化の時空間的制御機構2019
- Author(s)
  横須賀忠、若松英、矢那瀬紀子、秦喜久美、竹原朋宏、西航、町山裕亮
- Organizer
  第23回日本がん免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Indirect suppression of CD4+ T cell activation by LAG3-mediated trogocytosis of MHC Class II.2019
- Author(s)
  Wakamatsu E, Machiyama H, Toyota H, Furuhata M, Hata K, Yanase N, Yokosuka T
- Organizer
  第48回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] 末梢T細胞ではLckと共受容体CD4/CD8との協調的クラスター形成によって初期のTCRシグナルが惹起される2019
- Author(s)
  町山裕亮
- Organizer
  Kyoto T Cell Conference　第29回学術集会
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] Extrinsic and intrinsic inhibition of T cell response by co-inhibitory receptors, TIGIT and CD96.2019
- Author(s)
  Yanase N, Machiyama H, Toyota H, Furuhata M, Hata K, Takehara T, Wakamatsu E, Yokosuka T
- Organizer
  第48回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Molecular imaging unveils a mechanism of T cell activation regulation by immune checkpoint microclusters.2019
- Author(s)
  Tadashi Yokosuka, Ei Wakamatsu, Tomohiro Takehara, Kikumi Hata, Noriko Yanase,Hiroaki Machiyama
- Organizer
  The 23rd JFCR-ISCC New Antitumor Agents under Development in the US, Europe and Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] 末梢T細胞ではLckと共受容体CD4/CD8との協調的クラスター形成よって初期のTCRシグナルが惹起される2019
- Author(s)
  町山裕亮、若松英、秦喜久美、矢那瀬紀子、古畑昌枝、豊田博子、横須賀忠
- Organizer
  Kyot T cell Conference 第29回学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Lckキナーゼの構造・局在・ダイナミクスによるT細胞シグナル制御2019
- Author(s)
  町山裕亮
- Organizer
  理研シンポジウム「細胞システムの動態と理論XI」
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] 多様なT細胞シグナルソームによる腫瘍およびネオ・セルフ抗原認識の分子機構2019
- Author(s)
  横須賀忠、若松英、矢那瀬紀子、秦喜久美、竹原朋宏、西航、町山裕亮
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Programmed cell death 2 forms coinhibitory microclusters that directly attenuate T cell receptor signaling by recruiting the phosphatase SHP2.2019
- Author(s)
  Takehara T, Wakamatsu E, Machiyama H, Yanase N, Toyota H, Furuhata M, Koichi F, Soejima K, Yokosuka T
- Organizer
  第48回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Programmed cell death 2 forms coinhibitory microclusters that directly attenuate T cell receptor signaling by recruiting phosphatase SHP22019
- Author(s)
  Takehara T, Wakamatsu E, Machiyama H, Yanase N, Hata K, Toyoda H, Furuhata M, Yasuda H, Soejima K, Yokosuka T
- Organizer
  American Association fro Cancer Reserach
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Single molecule imaging reveals a distinct difference in Lck-dynamics between CD4+ and CD8+ T cells.2018
- Author(s)
  Hiroaki Machiyama
- Organizer
  47th Annual meeting of the Japanese Society for immunology
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] Dynamics of the PI3K signaling pathway induced by a T cell costimulator, ICOS.2018
- Author(s)
  Yokosuka Tadashi, Wakamatsu Ei, Yanase Noriko, Toyota Hiroko, Furuhata Masae, Hata Kikumi, Machiyama Hiroaki
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] T細胞シグナルの一分子・超解像イメージング法の開発2018
- Author(s)
  町山裕亮
- Organizer
  新学術領域「ネオ・セルフの生成・機能・構造」　第1回若手の会（第2回領域班会議）
- Data Source
  KAKENHI-PROJECT-15K19128
[Presentation] Cell-cell interaction among immune cells regulates T lymphocyte activation2018
- Author(s)
  Hiroaki Machiyama
- Organizer
  56th Annual Meeting of the Biophysical Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] 分子イメージングによる免疫チェックポイント療法によるT細胞の疲弊解除とその分子メカニズムの解明2018
- Author(s)
  横須賀忠、若松英、矢那瀬紀子、竹原朋宏、秦喜久美、町山裕亮
- Organizer
  第22回日本がん免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Cooperative regulation of thymic selection by receptor endocytosis and signal strength through TCR and E3 ubiquitin ligase c-Cbl microcluster formation.2018
- Author(s)
  Kikumi Hata, Hiroaki Machiyama, Noriko Yanase, Masae Furuhata, Hiroko Toyota, Ei Wakamatsu, Tadashi Yokosuka
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Development of the superresolution imaging in T cell signaling.2018
- Author(s)
  Hiroaki Machiyama
- Organizer
  56th Annual Meeting of the Biophysical Society of Japan
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] 胸腺ダブルポジティブT細胞におけるc-Cblのシグナルソーム形成と胸腺選択との相関2018
- Author(s)
  秦喜久美、町山裕亮、若松英、豊田博子、古畑昌枝、矢那瀬紀子、横須賀忠
- Organizer
  Kyoto T cell Conference 第28回学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Molecular imaging of the hCD19 CAR signalosomes, “CAR microclusters”.2018
- Author(s)
  Yanase Noriko, Machiyama Hiroaki, Wakamatsu Ei, Toyota Hiroko, Furuhata Masae, Hata Kikumi, Mamonkin Maksim, Brenner Malcolm K, Yokosuka Tadashi
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Single molecule imaging unveils a distinct difference in Lck-dynamics between CD4+ and CD8+ T cells.2018
- Author(s)
  Hiroaki Machiyama, Ei Wakamatsu, Noriko Yanase, Kikumi Hata, Masae Furuhata, Hiroko Toyota, Tadashi Yokosuka
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Microclusters as a functional unit for endocytosis of TCRs2017
- Author(s)
  Yokosuka T, Machiyama H, Hata K, Yanase N, Hashimoto-Tane A, Siato T
- Organizer
  第46回日本免疫学会総会学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Molecular mechanism of T cell signaling termination2017
- Author(s)
  Hiroaki Machiyama, Tadashi Yokosuka
- Organizer
  第５５回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-15K19128
[Presentation] ナイーブＴ細胞の抗原応答性は相互作用する細胞組成により調節される2017
- Author(s)
  町山　裕亮
- Organizer
  第６回日本生物物理学会関東支部会
- Place of Presentation
  早稲田大学先端生命医科学センター
- Year and Date
  2017-03-13
- Data Source
  KAKENHI-PROJECT-15K19128
[Presentation] 獲得免疫応答におけるTリンパ球の単一細胞測定系の開発2016
- Author(s)
  町山裕亮, 山口智之, 渡邉朋信, 藤田英明
- Organizer
  第54回日本生物物理学会大会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-15K19128
[Presentation] Single-molecule fluorescence microscopy reveals the role of Src SH3-domain in the mobility of c-Src at the cell membrane2015
- Author(s)
  Machiyama Hiroaki
- Organizer
  2015 ASCB annual meeting
- Place of Presentation
  San Diego Convention Center(米国)
- Year and Date
  2015-12-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19128

1. Yokosuka Tadashi (10359599)

# of Collaborated Projects: 3 results

# of Collaborated Products: 57 results
2. 若松英 (40632617)

# of Collaborated Projects: 2 results

# of Collaborated Products: 33 results
3. 矢那瀬紀子 (10210303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
4. 竹内新 (00360579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
5. 西嶋仁 (60425410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
6. 竹馬俊介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 市村垂生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 渡邉朋信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Machiyama Hiroaki 町山 裕亮

Research Projects

Research Products

Co-Researchers

Functions of TCR and coreceptors as regulating factors for T cell activation in CAR-T cell therapy.Principal Investigator

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Development of the basis of the crosstalk between T cell costimulatory receptors and chimeric antigen receptors

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Molecualr imaging for development of chimeric antigen receptors (CARs) resistant to T cell exhaustion

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Spatiotemporal mechanism in T cell signaling regulated by cell membrane dynamicsPrincipal Investigator

Principal Investigator

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Basic research for the development of a novel CAR-adaptor T cells by an advanced imaging system

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Regulation of antigen-specific immune responses by stoichiometric activated individual CD4 T cellsPrincipal Investigator

Principal Investigator

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[Book] Basic Immunology and Its Clinical Application2024

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[Book] Precision Medicine2022

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[Book] 腫瘍内科2022

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[Book] 「膜タンパク質工学ハンドブック」 第7章 第2節 免疫チェックポイント受容体PD-1とCTLA-42020

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[Book] 実験医学増刊号「新規の創薬モダリティ 細胞医薬」2020

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[Book] 実験医学増刊号「新・腫瘍免疫学」免疫チェックポイント分子の分子作用機序2019

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[Book] 実験医学 すべてはここから始まった、CTLA-42018

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[Book] 臨床免疫・アレルギー科 分子イメージングから考察した免疫チェックポイント分子のT細胞抑制機構2018

Machiyama Hiroaki 町山裕亮

[Book] 「膜タンパク質工学ハンドブック」第7章第2節免疫チェックポイント受容体PD-1とCTLA-42020

[Book] 実験医学増刊号「新規の創薬モダリティ　細胞医薬」2020

[Book] 実験医学すべてはここから始まった、CTLA-42018

[Book] 臨床免疫・アレルギー科　分子イメージングから考察した免疫チェックポイント分子のT細胞抑制機構2018

[Book] 東邦医学会雑誌分子イメージングが拓く免疫チェックポイント受容体のT細胞活性化制御機構2018