Machiyama Hiroaki 町山裕亮

Researcher Number	40704606
Other IDs
Affiliation (Current)	2021: 東京医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2017 – 2021: 東京医科大学, 医学部, 講師 2016: 東京医科大学, 医学部, 助教 2015: 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤)
Review Section/Research Field	Principal Investigator Immunology / Basic Section 43040:Biophysics-related Except Principal Investigator Tumor therapeutics / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator T細胞 / 獲得免疫 / 一細胞操作 / カルシウムイメージング / 1細胞操作 / 蛍光イメージング / 抗原特異性 / 単一細胞操作 / ライブセルイメージング / 数理モデル … More Except Principal Investigator 細胞療法 / 分子イメージング / シグナル伝達 / キメラ抗原受容体 / がん免疫 / T細胞 / キメラ抗原受容体T細胞 / 免疫学 / 免疫チェックポイント Less

Molecualr imaging for development of chimeric antigen receptors (CARs) resistant to T cell exhaustion
- Principal Investigator
  
  横須賀忠
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
Spatiotemporal mechanism in T cell signaling regulated by cell membrane dynamicsPrincipal Investigator
- Principal Investigator
  
  町山裕亮
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Tokyo Medical University
Basic research for the development of a novel CAR-adaptor T cells by an advanced imaging system
- Principal Investigator
  
  Yokosuka Tadashi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokyo Medical University
Regulation of antigen-specific immune responses by stoichiometric activated individual CD4 T cellsPrincipal Investigator
- Principal Investigator
  
  Machiyama Hiroaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical University
  Osaka University

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] 「膜タンパク質工学ハンドブック」第7章第2節免疫チェックポイント受容体PD-1とCTLA-42020
- Author(s)
  横須賀忠、若松英、町山裕亮
- Total Pages
  624
- Publisher
  株NTS
- ISBN
  9784860435370
- Data Source
  KAKENHI-PROJECT-17H03600
[Book] 実験医学増刊号「新・腫瘍免疫学」免疫チェックポイント分子の分子作用機序2019
- Author(s)
  横須賀忠、若松英、秦喜久美、竹原朋宏、西航、矢那瀬紀子、町山裕亮
- Total Pages
  268
- Publisher
  羊土社
- ISBN
  9784758103817
- Data Source
  KAKENHI-PROJECT-17H03600
[Book] 生物物理2018
- Author(s)
  横須賀忠、若松英、矢那瀬紀子、秦喜久美、町山裕亮
- Total Pages
  64
- Publisher
  日本生物物理学会
- ISBN
- Data Source
  KAKENHI-PROJECT-17H03600
[Book] 実験医学すべてはここから始まった、CTLA-42018
- Author(s)
  横須賀忠、若松英、古畑昌枝、豊田博子、秦喜久美、矢那瀬紀子、町山裕亮
- Total Pages
  138
- Publisher
  羊土社
- ISBN
- Data Source
  KAKENHI-PROJECT-17H03600
[Book] 東邦医学会雑誌分子イメージングが拓く免疫チェックポイント受容体のT細胞活性化制御機構2018
- Author(s)
  横須賀忠、若松英、秦喜久美、矢那瀬紀子、竹原朋宏、町山裕亮
- Total Pages
  22
- Publisher
  東邦医学会雑誌編集事務局
- ISBN
- Data Source
  KAKENHI-PROJECT-17H03600
[Book] 臨床免疫・アレルギー科　分子イメージングから考察した免疫チェックポイント分子のT細胞抑制機構2018
- Author(s)
  横須賀忠、若松英、古畑昌枝、豊田博子、秦喜久美、矢那瀬紀子、町山裕亮
- Total Pages
  119
- Publisher
  科学評論社
- ISBN
- Data Source
  KAKENHI-PROJECT-17H03600
[Journal Article] Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance2019
- Author(s)
  Yamaguchi Tomoyuki、Teraguchi Shunsuke、Furusawa Chikara、Machiyama Hiroaki、Watanabe Tomonobu M、Fujita Hideaki、Sakaguchi Shimon、Yanagida Toshio
- Journal Title
  
  International Immunology
  
  Volume: 31 Pages: 743-753
- DOI
  10.1093/intimm/dxz043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06165, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-15H05746
[Journal Article] A novel c-Src recruitment pathway from the cytosol to focal adhesions.2017
- Author(s)
  H. Machiyama, Yamaguchi T, Watanabe TM, Fujita H
- Journal Title
  
  FEBS Lett.
  
  Volume: 591 Pages: 1940-1046
- DOI
  10.1002/1873-3468.12696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26291028, KAKENHI-PROJECT-17H03600, KAKENHI-PROJECT-15K19128
[Journal Article] The use of a genetically encoded molecular crowding sensor in various biological phenomena2017
- Author(s)
  Hiroaki Machiyama, Takamitsu J. Morikawa, Kazuko Okamoto, Tomonobu M. Watanabe, Hideaki Fujita
- Journal Title
  
  BIOPHYSICS
  
  Volume: 14 Issue: 0 Pages: 119-125
- DOI
  10.2142/biophysico.14.0_119
- NAID
  130005987549
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03600, KAKENHI-PROJECT-15K19128
[Journal Article] Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells2017
- Author(s)
  Okada M, Chikuma S et al.
- Journal Title
  
  Cell Rep
  
  Volume: 20 Pages: 1017-1028
- DOI
  10.1016/j.celrep.2017.07.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K15451, KAKENHI-INTERNATIONAL-16K21731, KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06501, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H03600, KAKENHI-PROJECT-17H07088, KAKENHI-PROJECT-15J07566, KAKENHI-PROJECT-15K19128
[Journal Article] Non-label immune cell state prediction using Raman spectroscopy2017
- Author(s)
  Taro Ichimura, Liang-da Chiu, Katsumasa Fujita, Hiroaki Machiyama, Tomoyuki Yamaguchi, Tomonobu M. Watanabe, and Hideaki Fujita
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Pages: 37562-37562
- DOI
  10.1038/srep37562
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01439, KAKENHI-PROJECT-26286063, KAKENHI-PROJECT-15K20950, KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-16K14717, KAKENHI-PROJECT-15K19128, KAKENHI-PROJECT-26291028
[Presentation] 一分子動態解析法を用いたT細胞活性化におけるシグナルソームの時空間的制御機構の解明　～簡単・簡便なキメラ抗原受容体CAR-T細胞療法に向けて～2021
- Author(s)
  町山裕亮
- Organizer
  第36回日本DDS学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] Visualizing of neo-self phenomena in Chimeric antigen receptor (CAR)-T cells.2021
- Author(s)
  町山裕亮
- Organizer
  第58回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] キメラ抗原受容体（CAR）-T細胞活性化と細胞骨格、Role of cytoskeleton in Chimeric antigen receptor (CAR)-T cell therapy2021
- Author(s)
  町山裕亮
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] 末梢T細胞ではLckと共受容体CD4/CD8との協調的クラスター形成によって初期のTCRシグナルが惹起される2019
- Author(s)
  町山裕亮
- Organizer
  Kyoto T Cell Conference　第29回学術集会
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] 末梢T細胞ではLckと共受容体CD4/CD8との協調的クラスター形成よって初期のTCRシグナルが惹起される2019
- Author(s)
  町山裕亮、若松英、秦喜久美、矢那瀬紀子、古畑昌枝、豊田博子、横須賀忠
- Organizer
  Kyot T cell Conference 第29回学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Lckキナーゼの構造・局在・ダイナミクスによるT細胞シグナル制御2019
- Author(s)
  町山裕亮
- Organizer
  理研シンポジウム「細胞システムの動態と理論XI」
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Programmed cell death 2 forms coinhibitory microclusters that directly attenuate T cell receptor signaling by recruiting phosphatase SHP22019
- Author(s)
  Takehara T, Wakamatsu E, Machiyama H, Yanase N, Hata K, Toyoda H, Furuhata M, Yasuda H, Soejima K, Yokosuka T
- Organizer
  American Association fro Cancer Reserach
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] 多様なT細胞シグナルソームによる腫瘍およびネオ・セルフ抗原認識の分子機構2019
- Author(s)
  横須賀忠、若松英、矢那瀬紀子、秦喜久美、竹原朋宏、西航、町山裕亮
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Molecular imaging unveils a mechanism of T cell activation regulation by immune checkpoint microclusters.2019
- Author(s)
  Tadashi Yokosuka, Ei Wakamatsu, Tomohiro Takehara, Kikumi Hata, Noriko Yanase,Hiroaki Machiyama
- Organizer
  The 23rd JFCR-ISCC New Antitumor Agents under Development in the US, Europe and Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Different requirement of the coreceptors CD4 and CD8 for initiation of T cell activation.2019
- Author(s)
  Hiroaki Machiyama, Ei Wakamatsu, Kikumi Hata, Noriko Yanase, Masae Furuhata, Hiroko Toyota, Tadashi Yokosuka
- Organizer
  The 48th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] Different requirement of the coreceptors CD4 and CD8 for initiation of T cell activation.2019
- Author(s)
  Machiyama H Wakamatsu E, Hata K, Yanase N, Furuhata M, Toyota H, Yokosuka T
- Organizer
  第48回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] CARマイクロクラスターによる腫瘍抗原の認識とCAR-T細胞活性化の時空間的制御機構2019
- Author(s)
  横須賀忠、若松英、矢那瀬紀子、秦喜久美、竹原朋宏、西航、町山裕亮
- Organizer
  第23回日本がん免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Programmed cell death 2 forms coinhibitory microclusters that directly attenuate T cell receptor signaling by recruiting the phosphatase SHP2.2019
- Author(s)
  Takehara T, Wakamatsu E, Machiyama H, Yanase N, Toyota H, Furuhata M, Koichi F, Soejima K, Yokosuka T
- Organizer
  第48回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Indirect suppression of CD4+ T cell activation by LAG3-mediated trogocytosis of MHC Class II.2019
- Author(s)
  Wakamatsu E, Machiyama H, Toyota H, Furuhata M, Hata K, Yanase N, Yokosuka T
- Organizer
  第48回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Extrinsic and intrinsic inhibition of T cell response by co-inhibitory receptors, TIGIT and CD96.2019
- Author(s)
  Yanase N, Machiyama H, Toyota H, Furuhata M, Hata K, Takehara T, Wakamatsu E, Yokosuka T
- Organizer
  第48回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Development of the superresolution imaging in T cell signaling.2018
- Author(s)
  Hiroaki Machiyama
- Organizer
  56th Annual Meeting of the Biophysical Society of Japan
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] Single molecule imaging reveals a distinct difference in Lck-dynamics between CD4+ and CD8+ T cells.2018
- Author(s)
  Hiroaki Machiyama
- Organizer
  47th Annual meeting of the Japanese Society for immunology
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] 胸腺ダブルポジティブT細胞におけるc-Cblのシグナルソーム形成と胸腺選択との相関2018
- Author(s)
  秦喜久美、町山裕亮、若松英、豊田博子、古畑昌枝、矢那瀬紀子、横須賀忠
- Organizer
  Kyoto T cell Conference 第28回学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Cell-cell interaction among immune cells regulates T lymphocyte activation2018
- Author(s)
  Hiroaki Machiyama
- Organizer
  56th Annual Meeting of the Biophysical Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-18K06165
[Presentation] 分子イメージングによる免疫チェックポイント療法によるT細胞の疲弊解除とその分子メカニズムの解明2018
- Author(s)
  横須賀忠、若松英、矢那瀬紀子、竹原朋宏、秦喜久美、町山裕亮
- Organizer
  第22回日本がん免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Dynamics of the PI3K signaling pathway induced by a T cell costimulator, ICOS.2018
- Author(s)
  Yokosuka Tadashi, Wakamatsu Ei, Yanase Noriko, Toyota Hiroko, Furuhata Masae, Hata Kikumi, Machiyama Hiroaki
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Molecular imaging of the hCD19 CAR signalosomes, “CAR microclusters”.2018
- Author(s)
  Yanase Noriko, Machiyama Hiroaki, Wakamatsu Ei, Toyota Hiroko, Furuhata Masae, Hata Kikumi, Mamonkin Maksim, Brenner Malcolm K, Yokosuka Tadashi
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Single molecule imaging unveils a distinct difference in Lck-dynamics between CD4+ and CD8+ T cells.2018
- Author(s)
  Hiroaki Machiyama, Ei Wakamatsu, Noriko Yanase, Kikumi Hata, Masae Furuhata, Hiroko Toyota, Tadashi Yokosuka
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] T細胞シグナルの一分子・超解像イメージング法の開発2018
- Author(s)
  町山裕亮
- Organizer
  新学術領域「ネオ・セルフの生成・機能・構造」　第1回若手の会（第2回領域班会議）
- Data Source
  KAKENHI-PROJECT-15K19128
[Presentation] Cooperative regulation of thymic selection by receptor endocytosis and signal strength through TCR and E3 ubiquitin ligase c-Cbl microcluster formation.2018
- Author(s)
  Kikumi Hata, Hiroaki Machiyama, Noriko Yanase, Masae Furuhata, Hiroko Toyota, Ei Wakamatsu, Tadashi Yokosuka
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Microclusters as a functional unit for endocytosis of TCRs2017
- Author(s)
  Yokosuka T, Machiyama H, Hata K, Yanase N, Hashimoto-Tane A, Siato T
- Organizer
  第46回日本免疫学会総会学術集会
- Data Source
  KAKENHI-PROJECT-17H03600
[Presentation] Molecular mechanism of T cell signaling termination2017
- Author(s)
  Hiroaki Machiyama, Tadashi Yokosuka
- Organizer
  第５５回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-15K19128
[Presentation] ナイーブＴ細胞の抗原応答性は相互作用する細胞組成により調節される2017
- Author(s)
  町山　裕亮
- Organizer
  第６回日本生物物理学会関東支部会
- Place of Presentation
  早稲田大学先端生命医科学センター
- Year and Date
  2017-03-13
- Data Source
  KAKENHI-PROJECT-15K19128
[Presentation] 獲得免疫応答におけるTリンパ球の単一細胞測定系の開発2016
- Author(s)
  町山裕亮, 山口智之, 渡邉朋信, 藤田英明
- Organizer
  第54回日本生物物理学会大会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-15K19128
[Presentation] Single-molecule fluorescence microscopy reveals the role of Src SH3-domain in the mobility of c-Src at the cell membrane2015
- Author(s)
  Machiyama Hiroaki
- Organizer
  2015 ASCB annual meeting
- Place of Presentation
  San Diego Convention Center(米国)
- Year and Date
  2015-12-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19128

1. Yokosuka Tadashi (10359599)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
2. 矢那瀬紀子 (10210303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
3. 若松英 (40632617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. FUJITA Katsumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. YAMAGUCHI Tomoyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 渡邉朋信

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 竹馬俊介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 岡田匡央

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 近藤泰介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 坂口志文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 古澤力

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 市村垂生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 邱亮達

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Machiyama Hiroaki 町山 裕亮

Research Projects

Research Products

Co-Researchers

Molecualr imaging for development of chimeric antigen receptors (CARs) resistant to T cell exhaustion

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Spatiotemporal mechanism in T cell signaling regulated by cell membrane dynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic research for the development of a novel CAR-adaptor T cells by an advanced imaging system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of antigen-specific immune responses by stoichiometric activated individual CD4 T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 「膜タンパク質工学ハンドブック」 第7章 第2節 免疫チェックポイント受容体PD-1とCTLA-42020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 実験医学増刊号「新・腫瘍免疫学」免疫チェックポイント分子の分子作用機序2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 生物物理2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 実験医学 すべてはここから始まった、CTLA-42018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 東邦医学会雑誌 分子イメージングが拓く免疫チェックポイント受容体のT細胞活性化制御機構2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 臨床免疫・アレルギー科 分子イメージングから考察した免疫チェックポイント分子のT細胞抑制機構2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel c-Src recruitment pathway from the cytosol to focal adhesions.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The use of a genetically encoded molecular crowding sensor in various biological phenomena2017

Author(s)

Journal Title

DOI

NAID

ISSN

Machiyama Hiroaki 町山裕亮

[Book] 「膜タンパク質工学ハンドブック」第7章第2節免疫チェックポイント受容体PD-1とCTLA-42020

[Book] 実験医学すべてはここから始まった、CTLA-42018

[Book] 東邦医学会雑誌分子イメージングが拓く免疫チェックポイント受容体のT細胞活性化制御機構2018

[Book] 臨床免疫・アレルギー科　分子イメージングから考察した免疫チェックポイント分子のT細胞抑制機構2018

[Presentation] 一分子動態解析法を用いたT細胞活性化におけるシグナルソームの時空間的制御機構の解明　～簡単・簡便なキメラ抗原受容体CAR-T細胞療法に向けて～2021