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Machiyama Hiroaki  町山 裕亮

ORCIDConnect your ORCID iD *help
Researcher Number 40704606
Other IDs
Affiliation (Current) 2022: 東京医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2017 – 2021: 東京医科大学, 医学部, 講師
2016: 東京医科大学, 医学部, 助教
2015: 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤)
Review Section/Research Field
Principal Investigator
Immunology / Basic Section 43040:Biophysics-related
Except Principal Investigator
Tumor therapeutics / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords
Principal Investigator
T細胞 / 獲得免疫 / 一細胞操作 / カルシウムイメージング / 1細胞操作 / 蛍光イメージング / 抗原特異性 / 単一細胞操作 / ライブセルイメージング / 数理モデル … More / 制御性T細胞 / T細胞シグナル / 抗原認識 / 分子イメージング / シグナル伝達 / 細胞膜ダイナミクス … More
Except Principal Investigator
細胞療法 / 分子イメージング / シグナル伝達 / キメラ抗原受容体 / がん免疫 / T細胞 / キメラ抗原受容体T細胞 / 免疫学 / 免疫チェックポイント Less
  • Research Projects

    (4 results)
  • Research Products

    (41 results)
  • Co-Researchers

    (13 People)
  •  Molecualr imaging for development of chimeric antigen receptors (CARs) resistant to T cell exhaustion

    • Principal Investigator
      横須賀 忠
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Tokyo Medical University
  •  Spatiotemporal mechanism in T cell signaling regulated by cell membrane dynamicsPrincipal Investigator

    • Principal Investigator
      町山 裕亮
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43040:Biophysics-related
    • Research Institution
      Tokyo Medical University
  •  Basic research for the development of a novel CAR-adaptor T cells by an advanced imaging system

    • Principal Investigator
      Yokosuka Tadashi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor therapeutics
    • Research Institution
      Tokyo Medical University
  •  Regulation of antigen-specific immune responses by stoichiometric activated individual CD4 T cellsPrincipal Investigator

    • Principal Investigator
      Machiyama Hiroaki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Medical University
      Osaka University

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

  • [Book] 「膜タンパク質工学ハンドブック」 第7章 第2節 免疫チェックポイント受容体PD-1とCTLA-42020

    • Author(s)
      横須賀忠、若松英、町山裕亮
    • Total Pages
      624
    • Publisher
      株NTS
    • ISBN
      9784860435370
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Book] 実験医学増刊号「新・腫瘍免疫学」免疫チェックポイント分子の分子作用機序2019

    • Author(s)
      横須賀忠、若松英、秦喜久美、竹原朋宏、西航、矢那瀬紀子、町山裕亮
    • Total Pages
      268
    • Publisher
      羊土社
    • ISBN
      9784758103817
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Book] 生物物理2018

    • Author(s)
      横須賀忠、若松英、矢那瀬紀子、秦喜久美、町山裕亮
    • Total Pages
      64
    • Publisher
      日本生物物理学会
    • ISBN
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Book] 実験医学 すべてはここから始まった、CTLA-42018

    • Author(s)
      横須賀忠、若松英、古畑昌枝、豊田博子、秦喜久美、矢那瀬紀子、町山裕亮
    • Total Pages
      138
    • Publisher
      羊土社
    • ISBN
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Book] 東邦医学会雑誌 分子イメージングが拓く免疫チェックポイント受容体のT細胞活性化制御機構2018

    • Author(s)
      横須賀忠、若松英、秦喜久美、矢那瀬紀子、竹原朋宏、町山裕亮
    • Total Pages
      22
    • Publisher
      東邦医学会雑誌編集事務局
    • ISBN
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Book] 臨床免疫・アレルギー科 分子イメージングから考察した免疫チェックポイント分子のT細胞抑制機構2018

    • Author(s)
      横須賀忠、若松英、古畑昌枝、豊田博子、秦喜久美、矢那瀬紀子、町山裕亮
    • Total Pages
      119
    • Publisher
      科学評論社
    • ISBN
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Journal Article] Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance2019

    • Author(s)
      Yamaguchi Tomoyuki、Teraguchi Shunsuke、Furusawa Chikara、Machiyama Hiroaki、Watanabe Tomonobu M、Fujita Hideaki、Sakaguchi Shimon、Yanagida Toshio
    • Journal Title

      International Immunology

      Volume: 31 Pages: 743-753

    • DOI

      10.1093/intimm/dxz043

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06165, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-15H05746
  • [Journal Article] A novel c-Src recruitment pathway from the cytosol to focal adhesions.2017

    • Author(s)
      H. Machiyama, Yamaguchi T, Watanabe TM, Fujita H
    • Journal Title

      FEBS Lett.

      Volume: 591 Pages: 1940-1046

    • DOI

      10.1002/1873-3468.12696

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26291028, KAKENHI-PROJECT-17H03600, KAKENHI-PROJECT-15K19128
  • [Journal Article] The use of a genetically encoded molecular crowding sensor in various biological phenomena2017

    • Author(s)
      Hiroaki Machiyama, Takamitsu J. Morikawa, Kazuko Okamoto, Tomonobu M. Watanabe, Hideaki Fujita
    • Journal Title

      BIOPHYSICS

      Volume: 14 Issue: 0 Pages: 119-125

    • DOI

      10.2142/biophysico.14.0_119

    • NAID

      130005987549

    • ISSN
      2189-4779
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03600, KAKENHI-PROJECT-15K19128
  • [Journal Article] Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells2017

    • Author(s)
      Okada M, Chikuma S et al.
    • Journal Title

      Cell Rep

      Volume: 20 Pages: 1017-1028

    • DOI

      10.1016/j.celrep.2017.07.027

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K15451, KAKENHI-INTERNATIONAL-16K21731, KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06501, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H03600, KAKENHI-PROJECT-17H07088, KAKENHI-PROJECT-15J07566, KAKENHI-PROJECT-15K19128
  • [Journal Article] Non-label immune cell state prediction using Raman spectroscopy2017

    • Author(s)
      Taro Ichimura, Liang-da Chiu, Katsumasa Fujita, Hiroaki Machiyama, Tomoyuki Yamaguchi, Tomonobu M. Watanabe, and Hideaki Fujita
    • Journal Title

      Sci. Rep.

      Volume: 6 Pages: 37562-37562

    • DOI

      10.1038/srep37562

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-16H01439, KAKENHI-PROJECT-26286063, KAKENHI-PROJECT-15K20950, KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-16K14717, KAKENHI-PROJECT-15K19128, KAKENHI-PROJECT-26291028
  • [Presentation] 一分子動態解析法を用いたT細胞活性化におけるシグナルソームの時空間的制御機構の解明 ~簡単・簡便なキメラ抗原受容体CAR-T細胞療法に向けて~2021

    • Author(s)
      町山裕亮
    • Organizer
      第36回日本DDS学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K06165
  • [Presentation] Visualizing of neo-self phenomena in Chimeric antigen receptor (CAR)-T cells.2021

    • Author(s)
      町山裕亮
    • Organizer
      第58回日本生物物理学会年会
    • Data Source
      KAKENHI-PROJECT-18K06165
  • [Presentation] キメラ抗原受容体(CAR)-T細胞活性化と細胞骨格、Role of cytoskeleton in Chimeric antigen receptor (CAR)-T cell therapy2021

    • Author(s)
      町山裕亮
    • Organizer
      第43回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K06165
  • [Presentation] 末梢T細胞ではLckと共受容体CD4/CD8との協調的クラスター形成によって初期のTCRシグナルが惹起される2019

    • Author(s)
      町山裕亮
    • Organizer
      Kyoto T Cell Conference 第29回学術集会
    • Data Source
      KAKENHI-PROJECT-18K06165
  • [Presentation] 末梢T細胞ではLckと共受容体CD4/CD8との協調的クラスター形成よって初期のTCRシグナルが惹起される2019

    • Author(s)
      町山裕亮、若松英、秦喜久美、矢那瀬紀子、古畑昌枝、豊田博子、横須賀忠
    • Organizer
      Kyot T cell Conference 第29回学術集会
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Lckキナーゼの構造・局在・ダイナミクスによるT細胞シグナル制御2019

    • Author(s)
      町山裕亮
    • Organizer
      理研シンポジウム「細胞システムの動態と理論XI」
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Programmed cell death 2 forms coinhibitory microclusters that directly attenuate T cell receptor signaling by recruiting phosphatase SHP22019

    • Author(s)
      Takehara T, Wakamatsu E, Machiyama H, Yanase N, Hata K, Toyoda H, Furuhata M, Yasuda H, Soejima K, Yokosuka T
    • Organizer
      American Association fro Cancer Reserach
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] 多様なT細胞シグナルソームによる腫瘍およびネオ・セルフ抗原認識の分子機構2019

    • Author(s)
      横須賀忠、若松英、矢那瀬紀子、秦喜久美、竹原朋宏、西航、町山裕亮
    • Organizer
      第92回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Molecular imaging unveils a mechanism of T cell activation regulation by immune checkpoint microclusters.2019

    • Author(s)
      Tadashi Yokosuka, Ei Wakamatsu, Tomohiro Takehara, Kikumi Hata, Noriko Yanase,Hiroaki Machiyama
    • Organizer
      The 23rd JFCR-ISCC New Antitumor Agents under Development in the US, Europe and Japan
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Different requirement of the coreceptors CD4 and CD8 for initiation of T cell activation.2019

    • Author(s)
      Hiroaki Machiyama, Ei Wakamatsu, Kikumi Hata, Noriko Yanase, Masae Furuhata, Hiroko Toyota, Tadashi Yokosuka
    • Organizer
      The 48th Annual Meeting of The Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-18K06165
  • [Presentation] Different requirement of the coreceptors CD4 and CD8 for initiation of T cell activation.2019

    • Author(s)
      Machiyama H Wakamatsu E, Hata K, Yanase N, Furuhata M, Toyota H, Yokosuka T
    • Organizer
      第48回日本免疫学会総会
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] CARマイクロクラスターによる腫瘍抗原の認識とCAR-T細胞活性化の時空間的制御機構2019

    • Author(s)
      横須賀忠、若松英、矢那瀬紀子、秦喜久美、竹原朋宏、西航、町山裕亮
    • Organizer
      第23回日本がん免疫学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Programmed cell death 2 forms coinhibitory microclusters that directly attenuate T cell receptor signaling by recruiting the phosphatase SHP2.2019

    • Author(s)
      Takehara T, Wakamatsu E, Machiyama H, Yanase N, Toyota H, Furuhata M, Koichi F, Soejima K, Yokosuka T
    • Organizer
      第48回日本免疫学会総会
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Indirect suppression of CD4+ T cell activation by LAG3-mediated trogocytosis of MHC Class II.2019

    • Author(s)
      Wakamatsu E, Machiyama H, Toyota H, Furuhata M, Hata K, Yanase N, Yokosuka T
    • Organizer
      第48回日本免疫学会総会
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Extrinsic and intrinsic inhibition of T cell response by co-inhibitory receptors, TIGIT and CD96.2019

    • Author(s)
      Yanase N, Machiyama H, Toyota H, Furuhata M, Hata K, Takehara T, Wakamatsu E, Yokosuka T
    • Organizer
      第48回日本免疫学会総会
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Development of the superresolution imaging in T cell signaling.2018

    • Author(s)
      Hiroaki Machiyama
    • Organizer
      56th Annual Meeting of the Biophysical Society of Japan
    • Data Source
      KAKENHI-PROJECT-18K06165
  • [Presentation] Single molecule imaging reveals a distinct difference in Lck-dynamics between CD4+ and CD8+ T cells.2018

    • Author(s)
      Hiroaki Machiyama
    • Organizer
      47th Annual meeting of the Japanese Society for immunology
    • Data Source
      KAKENHI-PROJECT-18K06165
  • [Presentation] 胸腺ダブルポジティブT細胞におけるc-Cblのシグナルソーム形成と胸腺選択との相関2018

    • Author(s)
      秦喜久美、町山裕亮、若松英、豊田博子、古畑昌枝、矢那瀬紀子、横須賀忠
    • Organizer
      Kyoto T cell Conference 第28回学術集会
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Cell-cell interaction among immune cells regulates T lymphocyte activation2018

    • Author(s)
      Hiroaki Machiyama
    • Organizer
      56th Annual Meeting of the Biophysical Society of Japan
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K06165
  • [Presentation] 分子イメージングによる免疫チェックポイント療法によるT細胞の疲弊解除とその分子メカニズムの解明2018

    • Author(s)
      横須賀忠、若松英、矢那瀬紀子、竹原朋宏、秦喜久美、町山裕亮
    • Organizer
      第22回日本がん免疫学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Dynamics of the PI3K signaling pathway induced by a T cell costimulator, ICOS.2018

    • Author(s)
      Yokosuka Tadashi, Wakamatsu Ei, Yanase Noriko, Toyota Hiroko, Furuhata Masae, Hata Kikumi, Machiyama Hiroaki
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Molecular imaging of the hCD19 CAR signalosomes, “CAR microclusters”.2018

    • Author(s)
      Yanase Noriko, Machiyama Hiroaki, Wakamatsu Ei, Toyota Hiroko, Furuhata Masae, Hata Kikumi, Mamonkin Maksim, Brenner Malcolm K, Yokosuka Tadashi
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Single molecule imaging unveils a distinct difference in Lck-dynamics between CD4+ and CD8+ T cells.2018

    • Author(s)
      Hiroaki Machiyama, Ei Wakamatsu, Noriko Yanase, Kikumi Hata, Masae Furuhata, Hiroko Toyota, Tadashi Yokosuka
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] T細胞シグナルの一分子・超解像イメージング法の開発2018

    • Author(s)
      町山裕亮
    • Organizer
      新学術領域「ネオ・セルフの生成・機能・構造」 第1回若手の会(第2回領域班会議)
    • Data Source
      KAKENHI-PROJECT-15K19128
  • [Presentation] Cooperative regulation of thymic selection by receptor endocytosis and signal strength through TCR and E3 ubiquitin ligase c-Cbl microcluster formation.2018

    • Author(s)
      Kikumi Hata, Hiroaki Machiyama, Noriko Yanase, Masae Furuhata, Hiroko Toyota, Ei Wakamatsu, Tadashi Yokosuka
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Microclusters as a functional unit for endocytosis of TCRs2017

    • Author(s)
      Yokosuka T, Machiyama H, Hata K, Yanase N, Hashimoto-Tane A, Siato T
    • Organizer
      第46回日本免疫学会総会学術集会
    • Data Source
      KAKENHI-PROJECT-17H03600
  • [Presentation] Molecular mechanism of T cell signaling termination2017

    • Author(s)
      Hiroaki Machiyama, Tadashi Yokosuka
    • Organizer
      第55回日本生物物理学会年会
    • Data Source
      KAKENHI-PROJECT-15K19128
  • [Presentation] ナイーブT細胞の抗原応答性は相互作用する細胞組成により調節される2017

    • Author(s)
      町山 裕亮
    • Organizer
      第6回日本生物物理学会関東支部会
    • Place of Presentation
      早稲田大学先端生命医科学センター
    • Year and Date
      2017-03-13
    • Data Source
      KAKENHI-PROJECT-15K19128
  • [Presentation] 獲得免疫応答におけるTリンパ球の単一細胞測定系の開発2016

    • Author(s)
      町山 裕亮, 山口 智之, 渡邉 朋信, 藤田 英明
    • Organizer
      第54回日本生物物理学会大会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2016-11-25
    • Data Source
      KAKENHI-PROJECT-15K19128
  • [Presentation] Single-molecule fluorescence microscopy reveals the role of Src SH3-domain in the mobility of c-Src at the cell membrane2015

    • Author(s)
      Machiyama Hiroaki
    • Organizer
      2015 ASCB annual meeting
    • Place of Presentation
      San Diego Convention Center(米国)
    • Year and Date
      2015-12-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19128
  • 1.  Yokosuka Tadashi (10359599)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 23 results
  • 2.  矢那瀬 紀子 (10210303)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 21 results
  • 3.  若松 英 (40632617)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  FUJITA Katsumasa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  YAMAGUCHI Tomoyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  渡邉 朋信
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 7.  竹馬 俊介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  岡田 匡央
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  近藤 泰介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  坂口 志文
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  古澤 力
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  市村 垂生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  邱 亮達
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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