Arakawa Hiroshi 荒川大

Researcher Number	40709028
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 大学院薬学研究科, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 金沢大学, 薬学系, 准教授 2016 – 2018: 金沢大学, 薬学系, 助教 2017: 金沢大学, 医薬保健研究域薬学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Physical pharmacy Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Transformative Research Areas, Section (II) / Medical pharmacy
Keywords	Principal Investigator トランスポーター / 薬物トランスポーター / グルクロン酸抱合 / 薬物代謝 / 薬物相互作用 / UDP-グルクロン酸転移酵素 / OAT2 / 小胞体 / 肝臓 / トリガータンパク質 … More / 慢性腎毒性 / 慢性腎不全 / インドキシル硫酸 / 尿酸 / 毒性 / 結合タンパク質 / NPT4 / CD38 / 炎症 / 尿中排泄 / 尿毒症物質 / 腎臓 / 薬物脳移行 / sgRNAスクリーニング / ノックアウト / アリピプラゾール / OCTN2 / スクリーニング / 脳移行性 / 血液脳関門 / 薬学 / 簡易毒性試験 / 尿中排泄率 / ペプチドトランスポーター / 画像診断 / 診断 / がん / MRI … More Except Principal Investigator NAD+ / 高尿酸血症 / 痛風 / 尿酸結合タンパク質 / 炎症 / CD38 / 尿酸 / 臓器間相互作用 / トランスポーター / 口腔乾燥症 / よだれ / 流涎 / 副作用 / スコポラミン / 抗コリン薬 / ピロカルピン / コリン作動薬 / 唾液 / 経皮製剤 / 尿酸低下療法 / 薬物動態 / 脂質代謝 / センサー / 受容体 / ドチヌラド / URAT1 / NDFIP1 / 尿酸結晶 / 免疫反応 / 血清尿酸値 / 相互作用 / 灌流共培養 / 臓器チップ / 数理モデル化 / 三次元培養 / 腎臓 / 肝臓 / 小腸 / マイクロフィジオロジカルシステム / radixin / P-糖タンパク / 組織差 / 消化管がん / 腎臓がん / MRP / P-糖たんぱく / MRPs / 多剤耐性 / 排出系トランスポーター / がん組織 / 足場タンパク / 網羅的な阻害 / MRPｓ / BCRP / P-gp Less

Elucidation of endoplasmic reticulum transporters in drug metabolismPrincipal Investigator
- Principal Investigator
  
  荒川大
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kanazawa University
尿酸結合タンパク質CD38を介した尿酸による炎症応答調節
- Principal Investigator
  
  玉井郁巳
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kanazawa University
Development of transdermal system topically targeted salivary gland for control of salivary secretion
- Principal Investigator
  
  石田奈津子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kanazawa University
Identification of nephrotoxic trigger proteins of uremic toxins for advocacy of CKD prevention and treatment methodsPrincipal Investigator
- Principal Investigator
  
  Arakawa Hiroshi
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kanazawa University
Identifivatina and functional analysis of urate binding proteins
- Principal Investigator
  
  Tamai Ikumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kanazawa University
Identification of blood-brain barrier transporters using sgRNA libraryPrincipal Investigator
- Principal Investigator
  
  Arakawa Hiroshi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kanazawa University
Crosstalks between different organs cultured in OrganS on-a-chip
- Principal Investigator
  
  Sakai Yasuyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
Drug discovery for peptide transporter targeting cancer diagnostic probe using magnetic Resonance ImagingPrincipal Investigator
- Principal Investigator
  
  Arakawa Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University
Organ-specific inactivation of cancer multidrug resistance by regulating membrane scaffold proteins
- Principal Investigator
  
  Ogihara Takuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Takasaki University of Health and Welfare

All 2024 2023 2022 2021 2020 2016 2015

All Journal Article Presentation

[Journal Article] Unique binding sites of uricosuric agent dotinurad for selective inhibition of renal uric acid reabsorptive transporter URAT12024
- Author(s)
  Fujita K, Isozumi N, Zhu Q, Matsubayashi M, Taniguchi T, Arakawa H, Shirasaka Y, Mori E, Tamai I.
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics.
  
  Volume: 390 Issue: 1 Pages: 1-9
- DOI
  10.1124/jpet.124.002096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02641
[Journal Article] Functional identification of soluble uric acid as an endogenous inhibitor of CD382024
- Author(s)
  Wen S, Arakawa H, Yokoyama S, Shirasaka Y, Higashida H, Tamai I.
- Journal Title
  
  eLife
  
  Volume: none Pages: 1-1
- DOI
  10.7554/elife.96962.1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18181, KAKENHI-PROJECT-22K19372, KAKENHI-PROJECT-21H02641
[Journal Article] Uric acid in health and disease. From physiological functions to pathological mechanisms.2024
- Author(s)
  Wen S, Arakawa H, Tamai I.
- Journal Title
  
  Pharmacology and Therapeutics
  
  Volume: 256 Pages: 108615-108615
- DOI
  10.1016/j.pharmthera.2024.108615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18181, KAKENHI-PROJECT-21H02641
[Journal Article] Role of Organic Anion Transporter NPT4 in Renal Handling of Uremic Toxin 3-indoxyl Sulfate2024
- Author(s)
  Imamura Rikako、Sugimoto Masahiro、Horike Shin-ichi、Terakawa Jumpei、Fujita Kazuki、Tamai Ikumi、Daikoku Takiko、Kato Yukio、Arakawa Hiroshi
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: -
- DOI
  10.1016/j.xphs.2024.04.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19372, KAKENHI-PROJECT-23K27339
[Journal Article] Enhancement and maintenance of hepatic metabolic functions by controlling 3D aggregation of cryopreserved human iPS cell-derived hepatocyte-like cells.2023
- Author(s)
  Tao F, Hanada S, Matsushima K, Arakawa H, Ishida N, Kato Y, Okimura S, Watanabe T, Kojima N
- Journal Title
  
  J Biosci Bioeng.
  
  Volume: 135 Issue: 2 Pages: 134-142
- DOI
  10.1016/j.jbiosc.2022.10.006
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20H05745, KAKENHI-PROJECT-20H02595
[Journal Article] Evaluation and Clarification of Enterohepatic Interactions in Pharmacokinetics2023
- Author(s)
  Arakawa H
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 143 Issue: 2 Pages: 101-104
- DOI
  10.1248/yakushi.22-00172
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2023-02-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05745
[Journal Article] Application Site of Transdermal Scopolamine Influences Efficacy and Drug Concentration in Salivary Glands in Rats2023
- Author(s)
  Ishida Natsuko、Oshima Yoshitaka、Katsura Ayano、Imamura Rikako、Arakawa Hiroshi、Shimada Tsutomu、Mizuno Satoshi、Sai Yoshimichi、Suga Yukio、Matsushita Ryo
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 12 Pages: 1805-1809
- DOI
  10.1248/bpb.b23-00561
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-12-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06232, KAKENHI-PROJECT-23K06253
[Journal Article] 尿酸の炎症反応を介した慢性腎臓病進展メカニズムと腎臓病態評価モデルの構築2023
- Author(s)
  荒川大
- Journal Title
  
  細胞
  
  Volume: 55 Pages: 43-46
- Data Source
  KAKENHI-PROJECT-22K19372
[Journal Article] Emerging Roles of Uremic Toxins and Inflammatory Cytokines in the Alteration of Hepatic Drug Disposition in Patients with Kidney Dysfunction2023
- Author(s)
  Arakawa H, Kato Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05745
[Journal Article] 尿酸の炎症反応を介した慢性腎臓病進展メカニズムと腎臓病態評価モデルの構築2023
- Author(s)
  荒川大
- Journal Title
  
  細胞
  
  Volume: 55 Pages: 43-46
- Data Source
  KAKENHI-PLANNED-20H05745
[Journal Article] Influence of CPM-dependent sorting on the multi-omics profile of hepatocyte-like cells matured in microscale biochips2022
- Author(s)
  Mathieu Danoy、Stephane Poulain、Benedikt Scheidecker、Rachid Jellali、Yannick Tauran、Marjorie Leduc、Johanna Bruce、Francoise Gilard、Bertrand Gakiere、Hiroshi Arakawa、Yukio Kato、Soo Hyeon Kim、Taketomo Kido、Atsushi Miyajima、Yasuyuki Sakai、Eric Leclerc
- Journal Title
  
  Biochemical Engineering Journal
  
  Volume: 181 Pages: 108408-108408
- DOI
  10.1016/j.bej.2022.108408
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22491, KAKENHI-PLANNED-20H05745, KAKENHI-PROJECT-21H02710
[Journal Article] Evaluation of Platinum Anticancer Drug-Induced Kidney Injury in Primary Culture of Rat Kidney Tissue Slices by Using Gas-Permeable Plates2022
- Author(s)
  Arakawa H, Nagao Y, Shiho N, Shirasaka Y, Tamai I
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 3 Pages: 316-322
- DOI
  10.1248/bpb.b21-00875
- NAID
  130008165854
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-03-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05745
[Journal Article] Accurate evaluation of hepatocyte metabolisms on a noble oxygen-permeable material with low sorption　characteristics2022
- Author(s)
  Benedikt Scheidecker, Mathieu Danoy, Takumi Kawanishi, Hirohsi Arakawa, Yukio Kato, Katsuhiro Esashika, Hiroshi Miyasako, Yasuyuki Sakai
- Journal Title
  
  Frontiers in Toxicology
  
  Volume: 4 Pages: 810478-810478
- DOI
  10.3389/ftox.2022.810478
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05745
[Journal Article] Cryopreserved human hepatocytes culture optimization on polymethylpentene oxygen permeable membranes for drug screening purposes2022
- Author(s)
  Mathieu Danoy, Benedikt Scheidecker, Hiroshi Arakawa, Katsuhiro Esashika, Naoki Ishida, Hiroyasu Ito, Hisaaki Yanai, Jun Takahashi, Masaki Nishikawa, Yukio Kato, Yasuyuki Sakai
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 9 Issue: 4 Pages: 135-144
- DOI
  10.2131/fts.9.135
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05745
[Journal Article] Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening2022
- Author(s)
  Moeno Kadoguchi, Hiroshi Arakawa, Ryokichi Honda, Kazuki Hotta, Yoshiyuki Shirasaka, Yoshiharu Deguchi, Ikumi Tamai
- Journal Title
  
  Pharmaceutical Research
  
  Volume: - Issue: 7 Pages: 1549-1559
- DOI
  10.1007/s11095-022-03223-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16039, KAKENHI-PROJECT-20K07165, KAKENHI-PLANNED-20H05745
[Journal Article] Multi-omics analysis of hiPSCs-derived HLCs matured on-chip revealed patterns typical of liver regeneration2021
- Author(s)
  Danoy M, Tauran Y, Poulain S, Jellali R, Bruce J, Leduc M, Gall M, Koui Y, Arakawa H, Gilard F, Kato Y, Kido T, Miyajima A, Sakai Y, Leclerc E
- Journal Title
  
  Biotechnology & Bioengineering
  
  Volume: 118 Issue: 10 Pages: 3716-3732
- DOI
  10.1002/bit.27667
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05745, KAKENHI-PROJECT-16H06328, KAKENHI-PROJECT-21H02710
[Journal Article] CD38 activation by monosodium urate crystals contributes to inflammatory responses in human and murine macrophages2021
- Author(s)
  Wen S, Arakawa H, Tamai I
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 581 Pages: 6-11
- DOI
  10.1016/j.bbrc.2021.10.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05745, KAKENHI-PROJECT-21H02641
[Journal Article] Drug Transcellular Transport Assay Using a High Porosity Honeycomb Film2021
- Author(s)
  Nakazono Y‡, Arakawa H‡, Nishino M, Yamaki I, Oba T, Tomotoshi K, Kakinuma C, Ogihara T, Tamai I
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 5 Pages: 635-641
- DOI
  10.1248/bpb.b20-00925
- NAID
  130008033244
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05745
[Journal Article] Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system2021
- Author(s)
  Shinohara Marie、Arakawa Hiroshi、Oda Yuuichi、Shiraki Nobuaki、Sugiura Shinji、Nishiuchi Takumi、Satoh Taku、Iino Keita、Leo Sylvia、Kato Yusuke、Araya Karin、Kawanishi Takumi、Nakatsuji Tomoki、Mitsuta Manami、Inamura Kosuke、Goto Tomomi、Shinha Kenta、Nihei Wataru、Komori Kikuo、Sakai Yasuyuki、Kimura Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 5437-5437
- DOI
  10.1038/s41598-021-84861-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H01849, KAKENHI-PLANNED-20H05745, KAKENHI-PROJECT-18H02154
[Journal Article] A Kinetic Pump Integrated Microfluidic Plate (KIM-Plate) with High Usability for Cell Culture-Based Multiorgan Microphysiological Systems2021
- Author(s)
  Shinha Kenta、Nihei Wataru、Nakamura Hiroko、Goto Tomomi、Kawanishi Takumi、Ishida Naoki、Yamazaki Nao、Imakura Yuki、Mima Shinji、Inamura Kosuke、Arakawa Hiroshi、Nishikawa Masaki、Kato Yukio、Sakai Yasuyuki、Kimura Hiroshi
- Journal Title
  
  Micromachines
  
  Volume: 12 Issue: 9 Pages: 1007-1007
- DOI
  10.3390/mi12091007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05744, KAKENHI-PROJECT-18H01849, KAKENHI-PLANNED-20H05745
[Journal Article] Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs.2016
- Author(s)
  Arakawa H, Kamioka H, Kanagawa M, Hatano Y, Idota Y, Yano K, Morimoto K, Ogihara T.
- Journal Title
  
  Biopharm Drug Dispos.
  
  Volume: 37 Issue: 1 Pages: 39-45
- DOI
  10.1002/bdd.1999
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078
[Journal Article] Different Regulation of P-Glycoprotein Function between Caco-2 and Caki-1 cells by ERM proteins2016
- Author(s)
  Yano K, Otsuka K, Kato Y, Kawabata H, Ohmori S, Arakawa H, Ogihara T.
- Journal Title
  
  J Pharm Pharmacol.
  
  Volume: 68 Issue: 3 Pages: 361-367
- DOI
  10.1111/jphp.12525
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078, KAKENHI-PROJECT-15K19014
[Journal Article] Interaction of Peptide Transporter 1 With d-Glucose and l-Glutamic Acid; Possible Involvement of Taste Receptors.2016
- Author(s)
  Arakawa H, Ohmachi T, Ichiba K, Kamioka H, Tomono T, Kanagawa M, Idota Y, Hatano Y, Yano K, Morimoto K, Ogihara T.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 105 Issue: 1 Pages: 339-342
- DOI
  10.1016/j.xphs.2015.11.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078, KAKENHI-PROJECT-25560062
[Journal Article] Recommended Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of P-Glycoprotein Substrates in Rats2015
- Author(s)
  Tomono T, Otsuka K, Yano K, Kanagawa M, Arakawa H, Ogihara T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 12 Pages: 1960-1963
- DOI
  10.1248/bpb.b15-00392
- NAID
  130005112643
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Specific binding of uric acid to NDFIP1 associates with hyperuricemia-induced ferroptosis2024
- Author(s)
  Zhu Q, Arakawa H, Shirasaka Y, Tamai I
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21H02641
[Presentation] 薬物トランスポーターを考慮した薬物誘発腎毒性の評価系構築2023
- Author(s)
  荒川大、樋口大智、玉井郁巳
- Organizer
  日本薬学会第143回
- Invited
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] CD38 mediates the distinct roles of soluble uric acid and MSU crystals in gouty inflammation2023
- Author(s)
  Shijie Wen, Hiroshi Arakawa, Kazuki Himi, Yoshiyuki Shirasaka, Ikumi Tamai
- Organizer
  第56回日本痛風・尿酸核酸学会総会
- Data Source
  KAKENHI-PROJECT-21H02641
[Presentation] Specific binding of uric acid to to NDFIP1 associates with hyperuricemia-induced ferroptosis2023
- Author(s)
  Zhu Q, Arakawa H, Isozumi N, Shirasaka Y, Mori E, Tamai I
- Organizer
  2023 American College of Rheumatology Covergence
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18181
[Presentation] Potentiation of Uricosuric Effect of Dotinurad by Trans-Inhibition of Uric Acid Reabsorptive Transporter URAT12023
- Author(s)
  Fujita K, Zhu Q, Arakawa H, Shirasaka Y, Tamai I
- Organizer
  第38回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-21H02641
[Presentation] Endoplasmic reticulum membrane transporter OAT2 regulates hepatic drug metabolism2023
- Author(s)
  Hiroshi Arakawa
- Organizer
  2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27339
[Presentation] Molecular identification of specific binding site of dotinurad to uric acid transporter URAT1 responsible for its selective uric acid reuptake inhibition2023
- Author(s)
  Fujita K, Isozumi N, Zhu Q, Matsubayashi M, Taniguchi T, Arakawa H, Shirasaka Y, Mori E, Tamai I
- Organizer
  第38回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-21H02641
[Presentation] Soluble uric acid is an endogenous inhibitor of CD382023
- Author(s)
  Wen S, Arakawa H, Ypkoyama S, Shirasaka Y, Higashida H, Tamai I
- Organizer
  2023 American College of Rheumatology Covergence
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02641
[Presentation] Specific binding of uric acid to NDFIP1 associates with hyperuricemia-induced ferroptosis2023
- Author(s)
  Zhu Q, Arakawa H, Isozumi N, Shirasaka Y, Mori E, Tamai I
- Organizer
  2023 American College of Rheumatology Covergence
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02641
[Presentation] Functional analysis of the organic anion transporter NPT4 by metabolomics approach2023
- Author(s)
  Rikako Imamura, Yumi Aizawa, Kazuki Fujita, Ikumi Tamai, Masahiro Sugimoto, Yukio Kato, Hiroshi Arakawa
- Organizer
  日本薬物動態学会第38回年会第23回シトクロムP450国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19372
[Presentation] 院内製剤スコポラミン軟膏の塗布部位が薬効に及ぼす影響　―流涎モデルラットを用いた基礎的検討―2023
- Author(s)
  桂あやの，大嶋祥高，石田奈津子，嶋田努，水野智詞，荒川大，崔吉道，菅幸生，石﨑純子，松下良
- Organizer
  第33回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-23K06232
[Presentation] Soluble uric acid is an endogenous inhibitor of CD2382023
- Author(s)
  Wen S, Arakawa H, Ypkoyama S, Shirasaka Y, Higashida H, Tamai I
- Organizer
  2023 American College of Rheumatology Covergence
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18181
[Presentation] Specific binding of uric acid to NDFIP1 associates with hyperuricemia-induced liver fat accumulation2022
- Author(s)
  Qiunan ZHU, Hiroshi ARAKAWA, Aimi TANIGUCHI, Yurika NAGAO, Yoshiyuki SHIRASAKA, Ikumi TAMAI
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21H02641
[Presentation] 樋口大智、根立志帆，玉井郁巳. トランスポーターが関わる薬物腎毒性を見逃さない2022
- Author(s)
  荒川大，樋口大智、根立志帆、玉井郁巳
- Organizer
  第 49 回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] CD38 activation contributes to gouty inflammation in vitro2022
- Author(s)
  Wen S, Arakawa S, Tamai I.
- Organizer
  日本痛風・尿酸核酸学会総会
- Data Source
  KAKENHI-PROJECT-21H02641
[Presentation] Functional enhancements and crosstalk of liver-small intestine in a 　micro-stirrer-based on-chip perfusion MPS with direct oxygenation2022
- Author(s)
  Dhimas Agung Kurniawan, Kousuke Inamura, Danoy Mathieu, Sohei Funaoka, 　Daichi Aihara, Takeshi Sakura, Takumi Kawanishi, Hiroshi Arakawa, Yukio Kato, Masaki Nishikawa, Hiroshi Kimura and Yasuyuki Sakai
- Organizer
  MPS World Summit 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] Enhanced metabolic functions of hepatocytes with aerobic respiration enabled by a new oxygen-permeable plate2022
- Author(s)
  Yasuyuki Sakai, Hiroyasu Ito, Fumiya Tokito, Mathieu Danoy, Takumi Kawanishi, Hiroshi Arakawa, Yukio Kato, Tomoaki Matsugi, Katsuhiro Esashika, Hiroshi Miyasako, Toru Sumita, Masaki Nishikawa
- Organizer
  The 2022 European Congress on Alternatives to Animal Testing (EUSAAT 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] Effect of direct oxygenation and coculture on primary hepatocytes & intestine 　epithelial cells cultured in stirrer-based microphysiological system (MPS) device2022
- Author(s)
  Dhimas Kurniawan, Kousuke Inamura, Mathieu Danoy, Sylvia Leo, 　Mutsumi Inamatsu, Sohei Funaoka, Daichi Aihara, Takeshi Sakura, Takumi Kawanishi, Hiroshi Arakawa, Yukio Kato, Masaki Nishikawa, Nobuaki Shiraki, Shoen Kume, Hiroshi Kimura, Yasuyuki Sakai
- Organizer
  Tissue Engineering and Regenerative Medicine International Society; Asia-Pacific Conference 2022 (TERMIS AP 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] 胆汁うっ滞時における腎毒性誘発薬物の腎動態変動. 第21回日本再生医療学会総会2022
- Author(s)
  荒川大
- Organizer
  第21回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] Trans-inhibitory effect of dotinurad, a uricosuric agent on uric acid reabsorptive transporter URAT12022
- Author(s)
  藤田一輝、朱秋楠、荒川大、玉井郁巳
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21H02641
[Presentation] 尿酸の生理作用解明を目指した尿酸結合タンパク質の探索2022
- Author(s)
  荒川大
- Organizer
  第６回北陸尿酸セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] オンチップ灌流・直接酸素供給マイクロフィジオロジカルシステムを用いた in vitro における肝－小腸薬物代謝関連クロストークの解明2022
- Author(s)
  Dhimas Kurniawan, 稲村恒亮, Mathieu Danoy, Sylvia Leo, 稲松睦, 舩岡創平, 相原大知, 佐倉武司, 荒川大, 加藤将夫, 松木智昭, 江刺家勝弘, 西川昌輝, 白木伸明, 粂昭苑, 木村啓志, 酒井康行
- Organizer
  第34回日本動物実験代替法学会
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] siRNAスクリーニング法を用いたpyrilamineの血液脳関門薬物輸送体の探索2021
- Author(s)
  角口萌乃、荒川大、玉井郁巳
- Organizer
  日本薬学会北陸支部第133回例会
- Data Source
  KAKENHI-PROJECT-20K16039
[Presentation] 肝障害に伴う腎薬物動態変化に関わる臓器間相互作用2021
- Author(s)
  荒川大、河西巧、加藤将夫
- Organizer
  第１５回メタボロームシンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] 腸肝臓器間相互作用による薬物動態変動の観測と分子メカニズムの解明2021
- Author(s)
  荒川大
- Organizer
  日本薬学会北陸支部133回例会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] 腸肝連結型MPSを用いた薬物代謝と臓器間相互作用の解析2021
- Author(s)
  荒川大、河西巧、加藤将夫
- Organizer
  CBI学会2020プログラム
- Invited
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] Challenge to clarify the role of endoplasmic reticulum membrane transporters in drug metabolism.2021
- Author(s)
  Arakawa H.
- Organizer
  日本薬物動態学会第36年会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] 肝小腸連結型MPSで見えてきた薬物代謝における臓器間相互作用2020
- Author(s)
  荒川大、河西巧、加藤将夫
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] 腸肝連結型microphysiological systemを用いた薬物動態の臓器連関研究2020
- Author(s)
  荒川大、河西巧、加藤将夫
- Organizer
  第20回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] ヒト腎臓がん細胞のP-gp およびMRPs 輸送機能における足場タンパクの関与2016
- Author(s)
  加藤木綿子、矢野健太郎、井戸田陽子、荒川大、荻原琢男
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 日米EU3局の薬物相互作用ガイドラインの概要まとめと比較2015
- Author(s)
  山田　浩行、荒川　大、楠本　久美子、小島　肇、荻原　琢男
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  船橋
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] がん組織におけるERMタンパクによるP-gp輸送機能の調節機構2015
- Author(s)
  加藤木綿子、矢野健太郎、大塚杏磨、荒川大、荻原琢男
- Organizer
  第8回トランスポーター研究会
- Place of Presentation
  慶応義塾大学薬学部
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 基質薬物とキノロン系抗菌薬との消化管吸収過程における相互作用2015
- Author(s)
  荻原　琢男、上岡　宏紀、金川　雅彦、井戸田　陽子、矢野　健太郎、森本　かおり、荒川　大
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Transcriptional factor Snail activates P-glycoprotein function in lung adenocarcinoma cells2015
- Author(s)
  伴野　拓巳、矢野　健太郎、荒川　大、荻原　琢男
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  東京　タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Utility of three-dimensional culture of human hepatocyte as a tool of drug metabolizing enzyme induction2015
- Author(s)
  荒川　大、上岡　宏紀、井戸田　陽子、矢野　健太郎、荻原　琢男
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  東京　タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Tissue-selective regulation of P-gp function in cancers by ERM proteins2015
- Author(s)
  矢野　健太郎、大塚　杏磨、加藤　木綿子、井戸田　陽子、荒川　大、荻原　琢男
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  東京　タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08078

1. Ogihara Takuo (80448886)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. Tamai Ikumi (20155237)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
3. 藤田光 (40782850)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Idota Yoko (90629594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. Sakai Yasuyuki (00235128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. 矢野健太郎 (40644290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
7. 杉浦慎治 (10399496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 若山友彦 (70305100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 白坂善之 (60453833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 中島美紀 (70266162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 石田奈津子 (70794220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 中村博幸 (30542253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 嶋田努 (90409384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. KOMORI Kikuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. DANOY MATHIEU

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 木村啓志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 西川昌輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Arakawa Hiroshi 荒川 大

Research Projects

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Co-Researchers

Elucidation of endoplasmic reticulum transporters in drug metabolismPrincipal Investigator

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尿酸結合タンパク質CD38を介した尿酸による炎症応答調節

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Development of transdermal system topically targeted salivary gland for control of salivary secretion

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Identification of nephrotoxic trigger proteins of uremic toxins for advocacy of CKD prevention and treatment methodsPrincipal Investigator

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Identifivatina and functional analysis of urate binding proteins

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Identification of blood-brain barrier transporters using sgRNA libraryPrincipal Investigator

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Crosstalks between different organs cultured in OrganS on-a-chip

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Drug discovery for peptide transporter targeting cancer diagnostic probe using magnetic Resonance ImagingPrincipal Investigator

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Organ-specific inactivation of cancer multidrug resistance by regulating membrane scaffold proteins

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[Journal Article] Unique binding sites of uricosuric agent dotinurad for selective inhibition of renal uric acid reabsorptive transporter URAT12024

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[Journal Article] Functional identification of soluble uric acid as an endogenous inhibitor of CD382024

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[Journal Article] Uric acid in health and disease. From physiological functions to pathological mechanisms.2024

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[Journal Article] Role of Organic Anion Transporter NPT4 in Renal Handling of Uremic Toxin 3-indoxyl Sulfate2024

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[Journal Article] Enhancement and maintenance of hepatic metabolic functions by controlling 3D aggregation of cryopreserved human iPS cell-derived hepatocyte-like cells.2023

Author(s)

Arakawa Hiroshi 荒川大

[Journal Article] Accurate evaluation of hepatocyte metabolisms on a noble oxygen-permeable material with low sorption　characteristics2022