watanabe hiroyuki 渡邊裕之

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WATANABE Hiroyuki 渡邊裕之

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Researcher Number	40710786
Other IDs
Affiliation (Current)	2025: 京都大学, 薬学研究科, 講師
Affiliation (based on the past Project Information) *help	2018 – 2024: 京都大学, 薬学研究科, 講師 2017: 京都大学, 薬学研究科(研究院), 助教 2016 – 2017: 京都大学, 薬学研究科, 助教 2016: 京都大学, 大学院薬学研究科, 研究員 2015: 京都大学, ウイルス研究所, 助教 2013 – 2014: 京都大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related / Complex systems / Medium-sized Section 52:General internal medicine and related fields Except Principal Investigator Physical pharmacy / Basic Section 52040:Radiological sciences-related / Tumor diagnostics / Radiation science
Keywords	Principal Investigator イメージング / SPECT / PET / アルツハイマー病 / 分子イメージング / グレリン / オレキシン / オレキシン受容体 / 放射性医薬品 / 受容体 … More / ケミカルラベリング / アミノ酸 / ラジオセラノスティクス / オリゴマー / 神経細胞死 / タウ / オレキシンン受容体 / PETイメージング / PET/SPECT / アルツハイマー / βセクレターゼ … More Except Principal Investigator イメージング / パーキンソン病 / レビー小体病 / αシヌクレイン / がん治療 / 光線照射療法 / 近赤外光 / 光音響法 / 分子イメージング / Liqud biopsy / 再生検 / 獲得耐性 / 獲得耐性機序 / EGFR-TKI / テーラーメード治療 / T790M / liquid biopsy / re-biopsy / βアミロイド / 診断 / 金属錯体 / 脳アミロイドアンギオパチー / 糖尿病 / 膵β細胞 / PET Less

脳-末梢連関の解明に資するグレリン受容体標的核医学イメージング法の開発Principal Investigator
- Principal Investigator
  
  渡邊裕之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kyoto University
Development of PET probes for elucidation of orexin systemsPrincipal Investigator
- Principal Investigator
  
  Watanabe Hiroyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kyoto University
Develoment of Radiometal Complexes for Selective Modification of Specific Amino AcidsPrincipal Investigator
- Principal Investigator
  
  Watanabe Hiroyuki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kyoto University
Development of nuclear medicine imaging method targeting alfa-synuclein aggregates for diagnosis and treatment of Lewy body disease.
- Principal Investigator
  
  Ono Masahiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kyoto University
意志力の解明に資する分子イメージングプローブの開発とその応用Principal Investigator
- Principal Investigator
  
  渡邊裕之
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
Optimization of re-biopsy and liquid biopsy to detect mutations relevant to acquired resistance
- Principal Investigator
  
  Tomomi Nakamura
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Saga University
オレキシン系の解明のための核医学分子イメージングプローブの開発Principal Investigator
- Principal Investigator
  
  渡邊裕之
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
Development of novel SPECT probes for the diagnosis and treatment of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Watanabe Hiroyuki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
Development of PET probes targeting pancreatic b-cells for early diagnosis and preemptive medicine of diabetes.
- Principal Investigator
  
  Saji Hideo
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
Development of novel probes for in vivo imaging of b-secretase activity in the brainPrincipal Investigator
- Principal Investigator
  
  Watanabe Hiroyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
Development of a cancer-targeted diagnosis-therapy workflow system utilizing photoacoustic effect with near-infrared light
- Principal Investigator
  
  Saji Hideo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
Development of nuclear medical imaging probes targeting cerebral amyloid antipathy
- Principal Investigator
  
  Ono Masahiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
Development of novel 99mTc labeled amyloid imaging probes for diagnosis of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  WATANABE Hiroyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Synthesis and biological evaluation of novel 18F-labeled 2,4-diaminopyrimidine derivatives for detection of ghrelin receptor in the brain2024
- Author(s)
  Saito Haruka、Watanabe Hiroyuki、Ono Masahiro
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 99 Pages: 129625-129625
- DOI
  10.1016/j.bmcl.2024.129625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02869
[Journal Article] Synthesis and Characterization of Novel Radioiodinated Triazole-Pyrolidine Derivative to Detect Orexin 2 Receptor in the Brain2023
- Author(s)
  Watanabe Hiroyuki、Ide Takuji、Ono Masahiro
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 71 Issue: 3 Pages: 234-239
- DOI
  10.1248/cpb.c22-00770
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2023-03-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02869
[Journal Article] Structure-Activity Relationships of Styrylquinoline and Styrylquinoxaline Derivatives as α-Synuclein Imaging Probes2022
- Author(s)
  Nakagawa K, Watanabe H, Kaide S, Ono M.
- Journal Title
  
  ACS Med Chem Lett
  
  Volume: 13 Issue: 10 Pages: 1598-1605
- DOI
  10.1021/acsmedchemlett.2c00279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03622
[Journal Article] Chalcone Analogue as New Candidate for Selective Detection of α-Synuclein Pathology2022
- Author(s)
  Kaide S, Watanabe H, Iikuni S, Hasegawa M, Itoh K, Ono M
- Journal Title
  
  ACS Chem Neurosci
  
  Volume: 13 Issue: 1 Pages: 16-26
- DOI
  10.1021/acschemneuro.1c00441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03622, KAKENHI-PROJECT-20J14694
[Journal Article] Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes2022
- Author(s)
  Akasaka T, Watanabe H, Kaide S, Iikuni S, Hasegawa M, Ono M
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 64 Pages: 128679-128679
- DOI
  10.1016/j.bmcl.2022.128679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03622
[Journal Article] Synthesis and Evaluation of 18F-Labeled Chalcone Analogue for Detection of α-Synuclein Aggregates in the Brain Using the Mouse Model2022
- Author(s)
  Kaide S, Watanabe H, Iikuni S, Hasegawa M, Ono M.
- Journal Title
  
  ACS Chem Neurosci
  
  Volume: 13 Issue: 20 Pages: 2982-2990
- DOI
  10.1021/acschemneuro.2c00473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03622
[Journal Article] Synthesis and biological evaluation of novel 18F-labeled phenylbenzofuran-2-carboxamide derivative for detection of orexin 1 receptor in the brain2021
- Author(s)
  Watanabe Hiroyuki、Idoko Yuki、Iikuni Shimpei、Ide Takuji、Shimizu Yoichi、Nakamoto Yuji、Ono Masahiro
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 43 Pages: 128098-128098
- DOI
  10.1016/j.bmcl.2021.128098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02869
[Journal Article] SPECT用タウイメージングプローブの開発2021
- Author(s)
  渡邊裕之、小野正博
- Journal Title
  
  細胞
  
  Volume: 53 Pages: 41-43
- NAID
  40022468828
- Data Source
  KAKENHI-PROJECT-17H05092
[Journal Article] Characterization and Optimization of Benzimidazopyrimidine and Pyridoimidazopyridine Derivatives as Tau-SPECT Probes2021
- Author(s)
  Hiroyuki Watanabe, Takeaki Kishimoto, Sho Kaide, Yuta Tarumizu, Haruka Tatsumi, Shimpei Iikuni, Masahiro Ono
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: - Issue: 5 Pages: 805-811
- DOI
  10.1021/acsmedchemlett.1c00071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05092
[Journal Article] Structure-Activity and Brain Kinetics Relationships of 18F-Labeled Benzimidazopyridine Derivatives as Tau PET Tracers2021
- Author(s)
  Hiroyuki Watanabe, Yuta Tarumizu, Sho Kaide, Yoichi Shimizu, Shimpei Iikuni, Yuji Nakamoto, Masahiro Ono
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 12 Issue: 2 Pages: 262-266
- DOI
  10.1021/acsmedchemlett.0c00641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05092
[Journal Article] Identification and Evaluation of Bisquinoline Scaffold as a New Candidate for α-Synuclein-PET Imaging2020
- Author(s)
  Kaide S, Watanabe H, Shimizu Y, Iikuni S, Nakamoto Y, Hasegawa M, Itoh K, Ono M.
- Journal Title
  
  ACS Chem Neurosci
  
  Volume: 11 Issue: 24 Pages: 4254-4261
- DOI
  10.1021/acschemneuro.0c00523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03622, KAKENHI-PROJECT-20J14694
[Journal Article] Structure?Activity Relationships of Radioiodinated 6,5,6-Tricyclic Compounds for the Development of Tau Imaging Probes2020
- Author(s)
  Watanabe H，Tatsumi H，Kaide S，Shimizu Y，Iikuni S，Ono M.
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 11 Issue: 2 Pages: 120-126
- DOI
  10.1021/acsmedchemlett.9b00456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05092
[Journal Article] 18F-labeled benzimidazopyridine derivatives for PET imaging of tau pathology in Alzheimer’s disease2019
- Author(s)
  Kaide S，Watanabe H，Shimizu Y，Tatsumi H，Iikuni S，Nakamoto Y，Togashi K，Ihara M，Saji H，Ono M.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 16 Pages: 3587-3594
- DOI
  10.1016/j.bmc.2019.06.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05092
[Journal Article] Synthesis and biological evaluation of F-18 labeled tetrahydroisoquinoline derivatives targeting orexin 1 receptor2019
- Author(s)
  Watanabe H, Fukui K, Shimizu Y, Idoko Y, Nakamoto Y, Togashi K, Saji H, Ono M.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Issue: 13 Pages: 1620-1623
- DOI
  10.1016/j.bmcl.2019.04.044
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H05018
[Journal Article] Synthesis and characterization of a novel 18F-labeled 2,5-diarylnicotinamide derivative targeting orexin 2 receptor2019
- Author(s)
  Watanabe H, Matsushita N, Shimizu Y, Iikuni S, Nakamoto Y, Togashi K, Ono M.
- Journal Title
  
  MedChemComm
  
  Volume: 10 Issue: 12 Pages: 2126-2130
- DOI
  10.1039/c9md00397e
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H05018
[Journal Article] Structure-Activity Relationships of Radioiodinated Benzoimidazopyridine Derivatives for Detection of Tau Pathology2018
- Author(s)
  Kaide S, Ono M, Watanabe H, Kitada A, Yoshimura M, Shimizu Y, Ihara M, Saji H.
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 9 Issue: 5 Pages: 478-483
- DOI
  10.1021/acsmedchemlett.8b00092
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05694, KAKENHI-PROJECT-17H05092
[Journal Article] Novel fluorescence probes based on the chalcone scaffold for in vitro staining of β-amyloid plaques2018
- Author(s)
  Watanabe Hiroyuki, Saji Hideo, Ono Masahiro.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 28 Issue: 19 Pages: 3242-3246
- DOI
  10.1016/j.bmcl.2018.08.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05092
[Journal Article] Conversion of iodine to fluorine-18 based on iodinated chalcone and evaluation for β-amyloid PET imaging2018
- Author(s)
  Kaide Sho, Ono Masahiro, Watanabe Hiroyuki, Shimizu Yoichi, Nakamoto Yuji, Togashi Kaori, Yamaguchi Aiko, Hanaoka Hirofumi, Saji Hideo.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 26 Issue: 12 Pages: 3352-3358
- DOI
  10.1016/j.bmc.2018.05.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05092
[Journal Article] Synthesis and biological evaluation of novel radioiodinated benzimidazole derivatives for imaging α-synuclein aggregates2017
- Author(s)
  Watanabe H, Ariyoshi T, Ozaki A, Ihara M, Ono M, Saji H
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 25 Issue: 24 Pages: 6398-6403
- DOI
  10.1016/j.bmc.2017.10.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04260, KAKENHI-PROJECT-17H05092
[Journal Article] Development of SPECT Probes for <i>In Vivo</i> Imaging of β-Amyloid and Tau Aggregates in the Alzheimer's Disease Brain2017
- Author(s)
  Watanabe H,
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 11 Pages: 1361-1365
- DOI
  10.1248/yakushi.17-00156
- NAID
  130006191239
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2017-11-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05092
[Journal Article] Imaging of Cerebral Amyloid Angiopathy with Bivalent 99mTc-Hydroxamamide Complexes2016
- Author(s)
  Shimpei Iikuni, Masahiro Ono, Hiroyuki Watanabe, Kenji Matsumura, Masashi Yoshimura, Hiroyuki Kimura, Hatsue Ishibashi-Ueda, Yoko Okamoto, Masafumi Ihara, Hideo Saji.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 25990-25990
- DOI
  10.1038/srep25990
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16J05493, KAKENHI-PROJECT-26293274
[Journal Article] Novel Bivalent 99mTc-Complex with N-Methyl-Substituted Hydroxamamide as Probe for Imaging of Cerebral Amyloid Angiopathy2016
- Author(s)
  Shimpei Iikuni, Masahiro Ono, Hiroyuki Watanabe, Masashi Yoshimura, Hatsue Ishibashi-Ueda, Masafumi Ihara, Hideo Saji.
- Journal Title
  
  PLoS One
  
  Volume: 11(9) Issue: 9 Pages: e0163969-e0163969
- DOI
  10.1371/journal.pone.0163969
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16J05493, KAKENHI-PROJECT-26293274
[Journal Article] Synthesis and Biological Evaluation of 123I-Labeled Pyridyl Benzoxazole Derivatives: Novel β-Amyloid Imaging Probes for Single-Photon Emission Computed Tomography.2015
- Author(s)
  Watanabe H, Ono M, Iikuni S, Okamoto Y, Ihara M, Takahashi R, Saji H.
- Journal Title
  
  RSC Adv.
  
  Volume: 5 Issue: 2 Pages: 1009-1015
- DOI
  10.1039/c4ra10742j
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25893109
[Journal Article] Novel PET/SPECT Probes for Imaging of Tau in Alzheimer’s Disease.2015
- Author(s)
  Watanabe H, Ono M, Saji H.
- Journal Title
  
  ScientificWorldJournal
  
  Volume: 2015 Issue: 1 Pages: 124192-124192
- DOI
  10.1155/2015/124192
- NAID
  120005666203
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25893109
[Journal Article] Enhancement of Binding Affinity for Amyloid Aggregates by Multivalent Interactions of 99mTc-Hydroxamamide Complexes2014
- Author(s)
  Iikuni S, Ono M, Watanabe H, Matsumura K, Yoshimura M, Harada N, Kimura H, Nakayama M, Saji H.
- Journal Title
  
  Mol Pharm
  
  Volume: 11 Issue: 4 Pages: 1132-1139
- DOI
  10.1021/mp400499y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293274
[Journal Article] Novel Radioiodinated 1,3,4-Oxadiazole Derivatives with Improved in Vivo Properties for SPECT Imaging of β-Amyloid Plaques2014
- Author(s)
  Hiroyuki Watanabe, Masahiro Ono, Hiroyuki Kimura, Kenji Matsumura, Masashi Yoshimura, Shimpei Iikuni, Yoko Okamoto, Masafumi Ihara, Ryosuke Takahashi, Hideo Saji
- Journal Title
  
  Medicinal Chemistry Communications
  
  Volume: 5 Issue: 1 Pages: 82-85
- DOI
  10.1039/c3md00189j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893109
[Journal Article] A 68Ga complex based on benzofuran scaffold for the detection of β-amyloid plaques.2014
- Author(s)
  Watanabe H, Ono M, Iikuni S, Yoshimura M, Matsumura K, Kimura H, Saji H.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Issue: 20 Pages: 4834-4837
- DOI
  10.1016/j.bmcl.2014.08.058
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25893109
[Presentation] 中枢グレリン受容体のPETイメージングを目的とした新規18F標識ジアミノピリミジン誘導体の合成と評価2023
- Author(s)
  齋藤晴香、渡邊裕之、小野正博
- Organizer
  第20回次世代を担う若手のためのフィジカル・ファーマフォーラム
- Data Source
  KAKENHI-PROJECT-21H02869
[Presentation] 病態機能分析のための新規放射性プローブの開発研究2022
- Author(s)
  渡邊裕之, 小野正博
- Organizer
  第16回日本分子イメージング学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02869
[Presentation] オレキシン2受容体を標的としたトリアゾール-ピロリジン類縁体の合成と評価2022
- Author(s)
  渡邊裕之, 井出卓志, 小野正博
- Organizer
  第62回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02869
[Presentation] オレキシン1受容体イメージングを目的とした新規18F標識ベンゾフラン誘導体の合成と評価2022
- Author(s)
  石坂優衣, 渡邊裕之, 小野正博
- Organizer
  第19回次世代を担う若手のためのフィジカル・ファーマフォーラム
- Data Source
  KAKENHI-PROJECT-21H02869
[Presentation] αシヌクレインイメージングプローブの開発を目的とした新規18F標識スチリルキノリン/キノキサリン誘導体の合成と評価2021
- Author(s)
  中川航平, 渡邊裕之, 貝出翔, 飯國慎平, 志水陽一, 小野正博
- Organizer
  第4回日本核医学会分科会放射性薬品科学研究会/第19回放射性医薬品・画像診断薬研究会（仙台)
- Data Source
  KAKENHI-PROJECT-20H03622
[Presentation] 神経変性疾患における脳タンパク質凝集体を標的とした核医学イメージング法の開発2021
- Author(s)
  貝出翔, 渡邊裕之, 飯國慎平, 小野正博
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20H03622
[Presentation] 含窒素縮合3環系構造を基盤とした新規SPECT用タウイメージングプローブの開発2021
- Author(s)
  渡邊裕之、岸本峻明、貝出翔、垂水勇太、飯國慎平、小野正博
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-17H05092
[Presentation] カルコン類縁体を基盤としたαシヌクレイン標的PETイメージングプローブの開発2021
- Author(s)
  貝出翔, 渡邊裕之, 飯國慎平, 志水陽一, 長谷川成人, 伊東恭子, 小野正博
- Organizer
  第61回日本核医学会学術総会（名古屋）
- Data Source
  KAKENHI-PROJECT-20H03622
[Presentation] αシヌクレインイメージングプローブの開発を目的とした放射性ヨウ素標識オーロン誘導体の合成と評価2021
- Author(s)
  赤坂貴浩, 渡邊裕之, 貝出翔, 飯國慎平, 小野正博
- Organizer
  第18回次世代を担う若手のためのフィジカル・ファーマフォーラム (仙台)
- Data Source
  KAKENHI-PROJECT-20H03622
[Presentation] αシヌクレインの生体イメージングを目的とした放射性ヨウ素標識スチリルキノキサリン誘導体の合成および評価2021
- Author(s)
  中川航平, 渡邊裕之, 貝出翔, 飯國慎平, 長谷川成人, 伊東恭子, 小野正博
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20H03622
[Presentation] Development of PET probes targeting orexin receptors in the brain2021
- Author(s)
  渡邊裕之
- Organizer
  第61回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02869
[Presentation] アルツハイマー病脳内タウを標的とするSPECT用プローブの開発を目的とした125I標識ベンゾイミダゾピリミジン誘導体の構造活性動態相関研究2020
- Author(s)
  岸本峻明，渡邊裕之，辰巳悠華，貝出翔，垂水勇太，飯國慎平，志水陽一，小野正博
- Organizer
  第140年会日本薬学会
- Data Source
  KAKENHI-PROJECT-17H05092
[Presentation] オレキシン1受容体のPETイメージングを目的とした新規18F標識ベンゾフランおよびキノリン誘導体の合成と評価2020
- Author(s)
  井床有希，渡邊裕之，志水陽一，飯國慎平，小野正博
- Organizer
  第140年会日本薬学会
- Data Source
  KAKENHI-PUBLICLY-19H05018
[Presentation] 新規PET用タウイメージングプローブの開発を目的とした18F標識ベンゾイミダゾピリジン誘導体の合成と評価2019
- Author(s)
  垂水勇太，渡邊裕之，貝出翔，飯國慎平，志水陽一，小野正博
- Organizer
  第59回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17H05092
[Presentation] ヒト剖検脳切片を用いたBIP-NMe2に関する生化学評価2019
- Author(s)
  貝出翔，渡邊裕之，志水陽一，飯國慎平，伊東恭子，小野正博
- Organizer
  第59回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17H05092
[Presentation] Development of PET/SPECT Imaging Probes Based on Benzimidazopyridine Scaffold for Detection of Tau Pathology in Alzheimer's Disease2019
- Author(s)
  Sho Kaide, Hiroyuki Watanabe, Yoichi Shimizu, Shimpei Iikuni, Hideo Saji, Masahiro Ono
- Organizer
  The 11th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05092
[Presentation] アルツハイマー病脳内タウのPETイメージングを目的とした18F標識ベンゾイミダゾピリジン誘導体の構造活性動態相関2019
- Author(s)
  垂水勇太, 渡邊裕之, 貝出翔, 飯國慎平, 志水陽一, 小野正博
- Organizer
  日本薬学会　第138年会
- Data Source
  KAKENHI-PROJECT-17H05092
[Presentation] アルツハイマー病脳内タウのPETイメージングを目的とした18F標識ベンゾイミダゾピリジン誘導体の開発2019
- Author(s)
  貝出翔，渡邊裕之，志水陽一，辰巳悠華，飯國慎平，小野正博
- Organizer
  第17回次世代を担う若手のためのフィジカル・ファーマフォーラム
- Data Source
  KAKENHI-PROJECT-17H05092
[Presentation] Synthesis and evaluation of 18F-labeled benzimidazopyridine derivatives as novel PET tracers for tau imaging2019
- Author(s)
  Hiroyuki Watanabe, Sho Kaide, Yuta Tarumizu, Yoichi Shimizu, Simpei Iikuni, Masahiro Ono
- Organizer
  23rd International Symposium on Radiopharmaceutical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05092
[Presentation] オレキシン2受容体を標的とした18F標識ジアリールニコチンアミド誘導体の合成と評価2019
- Author(s)
  渡邊裕之，松下直樹，志水陽一，飯國慎平，小野正博
- Organizer
  第59回核医学会学術総会
- Data Source
  KAKENHI-PUBLICLY-19H05018
[Presentation] アルツハイマー病脳内タウを標的とした放射性ヨウ素標識ベンゾイミダゾピリジン誘導体に関する構造活性相関研究2018
- Author(s)
  貝出翔, 小野正博, 渡邊裕之, 志水陽一, 佐治英郎
- Organizer
  第138年会日本薬学会
- Data Source
  KAKENHI-PROJECT-17H05092
[Presentation] ベンゾイミダゾピリジン骨格を基盤とする新規PET用タウイメージングプローブの開発2018
- Author(s)
  貝出翔, 渡邊裕之, 辰巳悠華, 志水陽一, 佐治英郎, 小野正博
- Organizer
  第58回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17H05092
[Presentation] オレキシン1受容体選択的なPETイメージングを目的とした新規18F標識テトラヒドロイソキノリン誘導体の合成と評価2018
- Author(s)
  福井謙吾，渡邊裕之，志水陽一，小野正博，佐治英郎
- Organizer
  第138年会日本薬学会
- Data Source
  KAKENHI-PUBLICLY-17H06055
[Presentation] オレキシン2受容体の生体イメージングを目的とした18F標識ジアリルニコチンアミド誘導体の合成と評価2018
- Author(s)
  松下直樹、渡邊裕之、志水陽一、小野正博、佐治英郎
- Organizer
  第13回日本分子イメージング学会総会・学術総会
- Data Source
  KAKENHI-PUBLICLY-17H06055
[Presentation] Synthesis and evaluation of 18F-labeled tetrahydroisoquinoline derivatives as novel PET probes for imaging orexin 1 receptors2018
- Author(s)
  Hiroyuki Watanabe, Kengo Fukui, Yoichi Shimizu, Hideo Saji, Masahiro Ono
- Organizer
  The 7th Annual IIIS Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H06055
[Presentation] アルツハイマー病脳のβアミロイド、タウの生体イメージングに資する放射性プローブの開発2017
- Author(s)
  渡邊裕之
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17H05092
[Presentation] αシヌクレインイメージングプローブの開発を目的とした新規ベンゾイミダゾール誘導体の合成と評価2017
- Author(s)
  有吉泰亮、渡邊裕之、小野正博、佐治英郎
- Organizer
  第12回日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-17H05092
[Presentation] βセクレターゼの酵素活性を標的とした新規放射性ヨウ素標識プローブの開発2016
- Author(s)
  渡邊裕之、川崎梓、小野正博、佐治英郎
- Organizer
  第11回日本分子イメージング学会学術集会
- Place of Presentation
  神戸市
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-15K19785
[Presentation] アルツハイマー病の早期診断および治療薬開発のための分子イメージングプローブの開発2016
- Author(s)
  渡邊裕之
- Organizer
  第136年会日本薬学会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K19785
[Presentation] 脳βセクレターゼの酵素活性の核医学イメージングを目的とした新規SPECT用プローブの開発2016
- Author(s)
  川崎梓, 渡邊裕之, 小野正博, 佐治英郎
- Organizer
  第56回日本核医学会
- Place of Presentation
  名古屋
- Year and Date
  2016-11-03
- Data Source
  KAKENHI-PROJECT-15K19785
[Presentation] 脳アミロイドアンギオパチーイメージングを目的とした新規2価99mTc錯体の合成と評価2015
- Author(s)
  飯國慎平, 小野正博, 渡邊裕之, 木村寛之, 佐治英郎
- Organizer
  第55回日本核医学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-26293274
[Presentation] Development of polyethylene glycol conjugated with indocyanine green as a photoacoustic tumor imaging probe2015
- Author(s)
  Kohei Sano, Kengo Kanazaki, Akira Makino, Atsushi Takahashi, Fumio Yamauchi, Tsutomu Homma, Hiroyuki Watanabe, Takashi Temma, Masahiro Ono, Hideo Saji
- Organizer
  World Molecular Imaging Congress 2015
- Place of Presentation
  Honolulu
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04637
[Presentation] アルツハイマー病の診断・治療のための核医学分子イメージングプローブの開発2015
- Author(s)
  渡邊裕之
- Organizer
  第28回バイオメディカル分析化学シンポジウム
- Place of Presentation
  長崎市
- Year and Date
  2015-08-21
- Invited
- Data Source
  KAKENHI-PROJECT-15K19785
[Presentation] ピリジルベンゾオキサゾールを母核としたSPECT用βアミロイドイメージングプローブの開発2013
- Author(s)
  渡邊裕之、小野正博、飯國慎平、木村寛之、佐治英郎
- Organizer
  第53回日本核医学会学術総会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-25893109
[Presentation] 脳アミロイドアンギオパチーの核医学分子イメージングを目的とした99mTc 標識ベンゾチアゾール誘導体の開発
- Author(s)
  飯國慎平, 小野正博, 渡邊裕之, 木村寛之, 佐治英郎
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293274
[Presentation] Molecular imaging of β-amyloid plaques in Alzheimer’s disease with single photon emission computed tomography
- Author(s)
  Hiroyuki Watanabe, Masahiro Ono, Hiroyuki Kimura, Hideo Saji.
- Organizer
  The 37th NAITO CONFERENCE
- Place of Presentation
  ヒルトンニセコビレッジ
- Year and Date
  2014-07-15 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25893109
[Presentation] β-アミロイドおよびタウの生体イメージングを目的としたSPECTプローブの開発
- Author(s)
  渡邊裕之, 小野正博, 木村寛之, 佐治英郎
- Organizer
  第54回日本核医学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-11-06 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-25893109
[Presentation] 脳アミロイドアンギオパチーの核医学イメージングを目的とした2価99mTc錯体の開発
- Author(s)
  飯國慎平、小野正博、渡邊裕之、木村寛之、佐治英郎
- Organizer
  第54回日本核医学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2014-11-06 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-26293274
[Presentation] 2 価 99mTc 錯体を用いた脳アミロイドアンギオパチーの生体イメージング
- Author(s)
  飯國慎平、小野正博、渡邊裕之、木村寛之、佐治英郎
- Organizer
  第12回次世代を担う若手のためのフィジカル・ファーマフォーラム
- Place of Presentation
  箱根
- Year and Date
  2014-07-14 – 2014-07-15
- Data Source
  KAKENHI-PROJECT-26293274

1. Ono Masahiro (80336180)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
2. KIMURA Hiroyuki (50437240)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
3. SANO Kohei (00546476)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. Saji Hideo (40115853)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 飯國慎平 (70837731)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
6. TEMMA Takashi (90378787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IHARA Masafumi (00372590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Tomomi Nakamura (90457490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 荒金尚子 (20321846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 佐藤明美 (20568357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 志水陽一 (90634212)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. MATSUMURA Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. YOSHIMURA Masashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

watanabe hiroyuki 渡邊 裕之

WATANABE Hiroyuki 渡邊 裕之

Research Projects

Research Products

Co-Researchers

脳-末梢連関の解明に資するグレリン受容体標的核医学イメージング法の開発Principal Investigator

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Development of PET probes for elucidation of orexin systemsPrincipal Investigator

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Develoment of Radiometal Complexes for Selective Modification of Specific Amino AcidsPrincipal Investigator

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Development of nuclear medicine imaging method targeting alfa-synuclein aggregates for diagnosis and treatment of Lewy body disease.

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意志力の解明に資する分子イメージングプローブの開発とその応用Principal Investigator

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Optimization of re-biopsy and liquid biopsy to detect mutations relevant to acquired resistance

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オレキシン系の解明のための核医学分子イメージングプローブの開発Principal Investigator

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Review Section

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Development of novel SPECT probes for the diagnosis and treatment of Alzheimer's diseasePrincipal Investigator

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Development of PET probes targeting pancreatic b-cells for early diagnosis and preemptive medicine of diabetes.

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Development of novel probes for in vivo imaging of b-secretase activity in the brainPrincipal Investigator

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Development of a cancer-targeted diagnosis-therapy workflow system utilizing photoacoustic effect with near-infrared light

Principal Investigator

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Development of nuclear medical imaging probes targeting cerebral amyloid antipathy

Principal Investigator

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Research Institution

Development of novel 99mTc labeled amyloid imaging probes for diagnosis of Alzheimer's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

watanabe hiroyuki 渡邊裕之

WATANABE Hiroyuki 渡邊裕之