OTSUKA IKUO 大塚郁夫

… Alternative Names

Otsuka Ikuo 大塚郁夫

Less

Researcher Number	40722880
Other IDs
Affiliation (Current)	2025: 神戸大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 神戸大学, 医学研究科, 講師 2023: 神戸大学, 医学部附属病院, 講師 2020 – 2022: 神戸大学, 医学研究科, 医学研究員 2016 – 2022: 神戸大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science Except Principal Investigator Basic Section 52030:Psychiatry-related / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator 体細胞モザイク / ゲノムワイド関連解析 / 自殺 / テロメア / メチル化年齢 / リスクマーカー / バイオマーカー / エピゲノム / ゲノム / 若年自殺 … More / 性差 / DNAメチル化 / X染色体 / 統合失調症 … More Except Principal Investigator 自殺 / ポリジェニックリスクスコア / ゲノムワイド関連解析 / GWAS / テロメア長 / 若年者 / iPS細胞 / アストロサイト / エピジェネティック年齢 / MIF / 統合失調症 / シングルセル解析 / エピゲノム / 若年自殺 / 大学生 / テロメア / 国際自殺遺伝学コンソーシアム / 自殺コンソーシアム / 人種横断的研究 / 国際コンソーシアム Less

若者を自殺に追い込む生物学的異常と可逆性：エピゲノム・シングルセルダイナミクス
- Principal Investigator
  
  菱本明豊
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kobe University
Epigenetic pathomechanisms of accelerated aging in schizophrenia
- Principal Investigator
  
  岡崎賢志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kobe University
Elucidation for genetic suicide risk and suicide-related aberrant somatic mosaicism through GWASPrincipal Investigator
- Principal Investigator
  
  大塚郁夫
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kobe University
Prediction and elucidation for suicide risk using polygenic risk score analysis
- Principal Investigator
  
  Hishimoto Akitoyo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kobe University
  Yokohama City University
Study of biomarker for youth suicide risk through blood telomere length
- Principal Investigator
  
  Mouri Kentaro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kobe University
Study of biomarker for youth suicide risk through genome and epigenome-wide dataPrincipal Investigator
- Principal Investigator
  
  Otsuka Ikuo
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kobe University
A worldwide study of genetic factor for suicide
- Principal Investigator
  
  Hishimoto Akitoyo
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kobe University
  Yokohama City University
Development of suicide risk markers for young people focusing on telomere length
- Principal Investigator
  
  Mouri Kentaro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kobe University
Analysis of aberrant methylation on CpG island of X chromosome in male schizophreniaPrincipal Investigator
- Principal Investigator
  
  Otsuka Ikuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Kobe University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] 不安と自殺・自傷ー特に遺伝学的知見の観点からー（臨床精神医学）2022
- Author(s)
  大塚郁夫、谷藤貴紀
- Total Pages
  1088
- Publisher
  アークメディア
- Data Source
  KAKENHI-PROJECT-21K15712
[Book] 臨床での活用が期待される自殺の生物学的知見（別冊・医学のあゆみ）2022
- Author(s)
  大塚郁夫、菱本明豊
- Total Pages
  101
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-21K15712
[Journal Article] Association study of a single nucleotide polymorphism in the hypoxia response element of the macrophage migration inhibitory factor gene promoter with suicide completers in the Japanese population2024
- Author(s)
  Shirai Toshiyuki、Okazaki Satoshi、Tanifuji Takaki、Otsuka Ikuo、Miyachi Masao、Okada Shohei、Shindo Ryota、Horai Tadasu、Mouri Kentaro、Takahashi Motonori、Kondo Takeshi、Ueno Yasuhiro、Hishimoto Akitoyo
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 44 Issue: 1 Pages: 262-266
- DOI
  10.1002/npr2.12410
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-21K07545, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-21H02852
[Journal Article] Relationship of Major Depressive Disorder and Schizophrenia Polygenic Risk Scores to Suicide: A Comparison Between European and Asian Ancestry Populations2024
- Author(s)
  Otsuka Ikuo、Galfalvy Hanga、Guo Jia、Akiyama Masato、Okazaki Satoshi、Terao Chikashi、Rujescu Dan、Turecki Gustavo、Hishimoto Akitoyo、Mann J. John
- Journal Title
  
  Archives of Suicide Research
  
  Volume: Online ahead of prin Issue: 1 Pages: 309-316
- DOI
  10.1080/13811118.2024.2332258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0194
[Journal Article] Epigenome‐wide association study on methamphetamine dependence2024
- Author(s)
  Shirai Toshiyuki、Okazaki Satoshi、Tanifuji Takaki、Otsuka Ikuo、Horai Tadasu、Mouri Kentaro、Takemura Yukihiro、Aso Katsuro、Yamamoto Noriya、Hishimoto Akitoyo
- Journal Title
  
  Addiction Biology
  
  Volume: 29 Issue: 3
- DOI
  10.1111/adb.13383
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-21K07545, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-21H02852
[Journal Article] Accelerated epigenetic aging in alcohol dependence2024
- Author(s)
  Shirai T, Okazaki S, Otsuka I, Miyachi M, Tanifuji T, Shindo R, Okada S, Minami H, Horai T, Mouri K, Hishimoto A.
- Journal Title
  
  Journal of Psychiatric Research
  
  Volume: 173 Pages: 175-182
- DOI
  10.1016/j.jpsychires.2024.03.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07545, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-21H02852
[Journal Article] Epigenetic clock analysis reveals increased plasma cystatin C levels based on DNA methylation in major depressive disorder.2023
- Author(s)
  Tanifuji T, Okazaki S, Otsuka I, Mouri K, Horai T, Shindo R, Shirai T, Hishimoto A.
- Journal Title
  
  Psychiatry Research
  
  Volume: Epub ahead of print Pages: 115103-115103
- DOI
  10.1016/j.psychres.2023.115103
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15712, KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-21H02852
[Journal Article] Association of two variable number of tandem repeats in the monoamine oxidase A gene promoter with suicide completion: The present study and meta‐analysis2023
- Author(s)
  Hasegawa Masashi、Tanifuji Takaki、Okazaki Satoshi、Otsuka Ikuo、Shirai Toshiyuki、Shindo Ryota、Horai Tadasu、Mouri Kentaro、Takahashi Motonori、Kondo Takeshi、Ueno Yasuhiro、Hishimoto Akitoyo
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 43 Issue: 3 Pages: 338-345
- DOI
  10.1002/npr2.12344
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-21K07545, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-21H02852
[Journal Article] Ribosomal DNA gene copies are increased in blood and brain of Japanese schizophrenia patients2023
- Author(s)
  Li Sen、Otsuka Ikuo、Tanifuji Takaki、Okazaki Satoshi、Horai Tadasu、Takahashi Motonori、Kondo Takeshi、Ueno Yasuhiro、Hishimoto Akitoyo
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 1 Pages: e0280694-e0280694
- DOI
  10.1371/journal.pone.0280694
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-21K15712, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-21H02852
[Journal Article] Accelerated epigenetic aging and decreased natural killer cells based on DNA methylation in patients with untreated major depressive disorder2023
- Author(s)
  Shindo Ryota、Tanifuji Takaki、Okazaki Satoshi、Otsuka Ikuo、Shirai Toshiyuki、Mouri Kentaro、Horai Tadasu、Hishimoto Akitoyo
- Journal Title
  
  npj Aging
  
  Volume: 9 Issue: 1 Pages: 19-19
- DOI
  10.1038/s41514-023-00117-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-21K07545, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-21H02852
[Journal Article] Subjective assessment of participants in education programs on clinical practice guidelines in the field of psychiatry2022
- Author(s)
  Ogasawara Kazuyoshi, Ikuo Otsuka, Akitoyo Hishimoto et al.
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: Epub Issue: 2 Pages: 221-225
- DOI
  10.1002/npr2.12245
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-20K07945, KAKENHI-PROJECT-21K17261, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-22K10463, KAKENHI-PROJECT-20H03611
[Journal Article] Successful electroconvulsive therapy for 22q11.2 deletion syndrome with Schizophrenia and Parkinson's disease2022
- Author(s)
  Tanifuji Takaki、Otsuka Ikuo、Kimura Atsushi、Horai Tadasu、Okazaki Satoshi、Satake Wataru、Hishimoto Akitoyo
- Journal Title
  
  Psychiatry and Clinical Neurosciences
  
  Volume: 76 Issue: 11 Pages: 603-604
- DOI
  10.1111/pcn.13467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-21K15712
[Journal Article] Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides?Baraitser syndrome2022
- Author(s)
  Shinko Yutaka、Okazaki Satoshi、Otsuka Ikuo、Horai Tadasu、Kim Saehyeon、Tanifuji Takaki、Hishimoto Akitoyo
- Journal Title
  
  Molecular Genetics & Genomic Medicine
  
  Volume: 10 Issue: 3
- DOI
  10.1002/mgg3.1876
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-21K15712, KAKENHI-PROJECT-20KK0194
[Journal Article] Epigenetic aging in Williams syndrome2022
- Author(s)
  Okazaki Satoshi、Kimura Ryo、Otsuka Ikuo、Tomiwa Kiyotaka、Funabiki Yasuko、Hagiwara Masatoshi、Murai Toshiya、Hishimoto Akitoyo
- Journal Title
  
  Journal of Child Psychology and Psychiatry
  
  Volume: 63 Issue: 12 Pages: 1553-1562
- DOI
  10.1111/jcpp.13613
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-19K08251, KAKENHI-PROJECT-21K15712, KAKENHI-PUBLICLY-21H05326, KAKENHI-PROJECT-23K22257
[Journal Article] Novel missense SETD1A variants in Japanese patients with schizophrenia: Resequencing and association analysis2022
- Author(s)
  Morikawa Ryo、Watanabe Yuichiro、Igeta Hirofumi、Arta Reza K.、Ikeda Masashi、Okazaki Satoshi、Hoya Satoshi、Saito Takeo、Otsuka Ikuo、Egawa Jun、Tanifuji Takaki、Iwata Nakao、Someya Toshiyuki
- Journal Title
  
  Psychiatry Research
  
  Volume: 310 Pages: 114481-114481
- DOI
  10.1016/j.psychres.2022.114481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07590, KAKENHI-PROJECT-21K15712, KAKENHI-PROJECT-21K07495, KAKENHI-PROJECT-21K07496, KAKENHI-PROJECT-20H03597
[Journal Article] The characteristics of patients receiving psychotropic pro re nata medication at discharge for the treatment of schizophrenia and major depressive disorder: A nationwide survey from the EGUIDE project2022
- Author(s)
  Ichihashi Kayo、Kyou Yoshitaka、Hasegawa Naomi、Yasui-Furukori Norio、（37人中32番目）Matsumoto Junya、et al
- Journal Title
  
  Asian Journal of Psychiatry
  
  Volume: 69 Pages: 103007-103007
- DOI
  10.1016/j.ajp.2022.103007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15522, KAKENHI-PROJECT-20H03611, KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-21K07486, KAKENHI-PROJECT-21K17261, KAKENHI-PROJECT-20KK0194
[Journal Article] Epigenetic clock analysis in methamphetamine dependence2022
- Author(s)
  Takemura Yukihiro、Tanifuji Takaki、Okazaki Satoshi、Shinko Yutaka、Otsuka Ikuo、Horai Tadasu、Shirai Toshiyuki、Aso Katsuro、Yamamoto Noriya、Hishimoto Akitoyo
- Journal Title
  
  Psychiatry Research
  
  Volume: 317 Pages: 114901-114901
- DOI
  10.1016/j.psychres.2022.114901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-21K15712
[Journal Article] Polymorphisms in the hypoxia inducible factor binding site of the macrophage migration inhibitory factor gene promoter in schizophrenia2022
- Author(s)
  Okazaki Satoshi、Boku Shuken、Watanabe Yuichiro、Otsuka Ikuo、Horai Tadasu、Morikawa Ryo、Kimura Atsushi、Shimmyo Naofumi、Tanifuji Takaki、Someya Toshiyuki、Hishimoto Akitoyo
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 3 Pages: e0265738-e0265738
- DOI
  10.1371/journal.pone.0265738
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-21K15712, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-20H03597
[Journal Article] Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors2022
- Author(s)
  Mullins N, Ikuo Otsuka, Akitoyo Hishimoto et al.
- Journal Title
  
  Biological Psychiatry
  
  Volume: 91 Issue: 3 Pages: 313-327
- DOI
  10.1016/j.biopsych.2021.05.029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-21K15712
[Journal Article] Preventive effects of preoperative ramelteon on postoperative delirium in Asian elderly population: A randomized, double-blind, placebo-controlled trial, and a systematic review and meta-analysis2022
- Author(s)
  Tanifuji Takaki、Otsuka Ikuo、Okazaki Satoshi、Horai Tadasu、So Ryuhei、Shiroiwa Kyoichi、Mouri Kentaro、Tanaka Motofumi、Ohmoto Nobuko、Sora Ichiro、Hirai Midori、Fukumoto Takumi、Ku Yonson、Hishimoto Akitoyo
- Journal Title
  
  Asian Journal of Psychiatry
  
  Volume: 78 Pages: 103282-103282
- DOI
  10.1016/j.ajp.2022.103282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-21K07545, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-21K15712
[Journal Article] Epigenetic clock analysis and increased plasminogen activator inhibitor-1 in high-functioning autism spectrum disorder2022
- Author(s)
  Okazaki Satoshi、Kimura Ryo、Otsuka Ikuo、Funabiki Yasuko、Murai Toshiya、Hishimoto Akitoyo
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 2 Pages: e0263478-e0263478
- DOI
  10.1371/journal.pone.0263478
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-19K08251, KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-21K18554, KAKENHI-PROJECT-21K15712, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-21KK0041, KAKENHI-PUBLICLY-21H05326
[Journal Article] 自殺の神経生物学的異常2021
- Author(s)
  大塚郁夫, 菱本明豊.
- Journal Title
  
  臨床精神医学
  
  Volume: 50(6) Pages: 577-583
- Data Source
  KAKENHI-PROJECT-21K15712
[Journal Article] 自殺の神経生物学的異常2021
- Author(s)
  大塚郁夫, 菱本明豊.
- Journal Title
  
  臨床精神医学
  
  Volume: 50(6) Pages: 577-583
- Data Source
  KAKENHI-PROJECT-21H02852
[Journal Article] Clozapine increases macrophage migration inhibitory factor (MIF) expression via increasing histone acetylation of MIF promoter in astrocytes.2021
- Author(s)
  Okazaki S, Boku S, Otsuka I, Horai T, Kimura A, Shimmyo N, Yamaki N, Hishimoto A.
- Journal Title
  
  J Psychiatr Res.
  
  Volume: 135 Pages: 237-242
- DOI
  10.1016/j.jpsychires.2021.01.033
- NAID
  120006996932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-18K15483
[Journal Article] Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits2021
- Author(s)
  Otsuka Ikuo、Galfalvy Hanga、Guo Jia、Akiyama Masato、Rujescu Dan、Turecki Gustavo、Hishimoto Akitoyo、Mann J. John
- Journal Title
  
  Psychological Medicine
  
  Volume: Epub Issue: 6 Pages: 1-9
- DOI
  10.1017/s0033291721004700
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15712, KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-21H02852
[Journal Article] 臨床での活用が期待される自殺の生物学的知見2021
- Author(s)
  大塚郁夫, 菱本明豊.
- Journal Title
  
  医学のあゆみ
  
  Volume: 279(1) Pages: 29-34
- Data Source
  KAKENHI-PROJECT-20KK0194
[Journal Article] Association of Two Variable Number of Tandem Repeats in the Monoamine Oxidase A Gene Promoter with Schizophrenia2021
- Author(s)
  Tanifuji Takaki、Okazaki Satoshi、Otsuka Ikuo、Horai Tadasu、Shinko Yutaka、Kim Saehyeon、Sora Ichiro、Hishimoto Akitoyo
- Journal Title
  
  Neuropsychiatric Disease and Treatment
  
  Volume: Volume 17 Pages: 3315-3323
- DOI
  10.2147/ndt.s338854
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-21K15712, KAKENHI-PROJECT-20KK0194
[Journal Article] Serum levels of glial cell line-derived neurotrophic factor as a biomarker for mood disorders and lithium response2021
- Author(s)
  Keita Idemoto, Tamaki Ishima, Tomihisa Niitsu, Tatsuki Hata, Sumiko Yoshida, Kotaro Hattori, Tadasu Horai, Ikuo Otsuka, Hidenaga Yamamori, Shigenobu Toda etc
- Journal Title
  
  Psychiatric Res
  
  Volume: 301 Pages: 113967-113967
- DOI
  10.1016/j.psychres.2021.113967
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10270, KAKENHI-PROJECT-19K08066, KAKENHI-PROJECT-20H03611, KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-20K07928, KAKENHI-PROJECT-21K15712, KAKENHI-PROJECT-20KK0194
[Journal Article] 臨床での活用が期待される自殺の生物学的知見2021
- Author(s)
  大塚郁夫, 菱本明豊.
- Journal Title
  
  医学のあゆみ
  
  Volume: 279(1) Pages: 29-34
- Data Source
  KAKENHI-PROJECT-21H02852
[Journal Article] A preliminary genetic association study of GAD1 and GABAB receptor genes in patients with treatment-resistant schizophrenia2021
- Author(s)
  Miyazawa Atsuhiro、Kanahara Nobuhisa、Kogure Masanobu、Otsuka Ikuo、Okazaki Satoshi、Watanabe Yoshinori、Yamasaki Fumiaki、Nakata Yusuke、Oda Yasunori、Hishimoto Akitoyo、Iyo Masaomi
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 49 Issue: 3 Pages: 2015-2024
- DOI
  10.1007/s11033-021-07019-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-21K07476, KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-21K15712, KAKENHI-PROJECT-21K15724, KAKENHI-PROJECT-20KK0194
[Journal Article] Searching for biomarkers in schizophrenia and psychosis: Case‐control study using capillary electrophoresis and liquid chromatography time‐of‐flight mass spectrometry and systematic review for biofluid metabolites2021
- Author(s)
  Kim Saehyeon、Okazaki Satoshi、Otsuka Ikuo、Shinko Yutaka、Horai Tadasu、Shimmyo Naofumi、Hirata Takashi、Yamaki Naruhisa、Tanifuji Takaki、Boku Shuken、Sora Ichiro、Hishimoto Akitoyo
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 42 Issue: 1 Pages: 42-51
- DOI
  10.1002/npr2.12223
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02852, KAKENHI-PROJECT-21K07520, KAKENHI-PROJECT-21K15712, KAKENHI-PROJECT-20KK0194
[Journal Article] 自殺の神経生物学的異常2021
- Author(s)
  大塚郁夫, 菱本明豊.
- Journal Title
  
  臨床精神医学
  
  Volume: 50(6) Pages: 577-583
- Data Source
  KAKENHI-PROJECT-20KK0194
[Journal Article] 臨床での活用が期待される自殺の生物学的知見2021
- Author(s)
  大塚郁夫, 菱本明豊.
- Journal Title
  
  医学のあゆみ
  
  Volume: 279(1) Pages: 29-34
- Data Source
  KAKENHI-PROJECT-21K15712
[Journal Article] Platelet-derived growth factor BB: A potential diagnostic blood biomarker for differentiating bipolar disorder from major depressive disorder.2021
- Author(s)
  Idemoto K, Ishima T, Niitsu T, Hata T, Yoshida S, Hattori K, Horai T, Otsuka I, Yamamori H, Toda S, Kameno Y, Ota K, Oda Y, Kimura A, Hashimoto T, Mori N, Kikuchi M, Minabe Y, Hashimoto R, Hishimoto A, Nakagome K, Iyo M, Hashimoto K.
- Journal Title
  
  J Psychiatr Res
  
  Volume: 134 Pages: 48-56
- DOI
  10.1016/j.jpsychires.2020.12.051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-20H03611, KAKENHI-PROJECT-18K15484, KAKENHI-PROJECT-17K10270, KAKENHI-PROJECT-19K08066, KAKENHI-PROJECT-18KT0022, KAKENHI-PROJECT-20K07928
[Journal Article] Epigenetic Clock Analysis in Children With Fetal Alcohol Spectrum Disorder2021
- Author(s)
  Okazaki Satoshi、Otsuka Ikuo、Shinko Yutaka、Horai Tadasu、Hirata Takashi、Yamaki Naruhisa、Sora Ichiro、Hishimoto Akitoyo
- Journal Title
  
  Alcoholism: Clinical and Experimental Research
  
  Volume: 45 Issue: 2 Pages: 329-337
- DOI
  10.1111/acer.14532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-18K15483
[Journal Article] miR-19b is elevated in peripheral blood of schizophrenic patients and attenuates proliferation of hippocampal neural progenitor cells2020
- Author(s)
  Horai T, Boku S, Okazaki S, Otsuka I, Ratta-Apha W, Mouri K, Yamaki N, Hirata T, Hishimoto A.
- Journal Title
  
  J Psychiatr Res .
  
  Volume: 131 Pages: 102-107
- DOI
  10.1016/j.jpsychires.2020.09.006
- NAID
  120006952760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-18K07599, KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-18K15484
[Journal Article] Epigenetic clock analysis of blood samples from Japanese schizophrenia patients.2019
- Author(s)
  Okazaki S, Otsuka I, Numata S, Horai T, Mouri K, Boku S, Ohmori T, Sora I, Hishimoto A.
- Journal Title
  
  NPJ Schizophrenia
  
  Volume: 5 Issue: 1 Pages: 4-4
- DOI
  10.1038/s41537-019-0072-1
- NAID
  120006629323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07599, KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-18K15484, KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-16K19765, KAKENHI-PROJECT-18H02751
[Journal Article] Mitochondrial DNA copy number raises the potential of left frontopolar hemodynamic response as a diagnostic marker for distinguishing bipolar disorder from major depressive disorder.2019
- Author(s)
  Tsujii N, Otsuka I, Okazaki S, Yanagi M, Numata S, Yamaki N, Kawakubo Y, Shirakawa O, Hishimoto A.
- Journal Title
  
  Frontiers in Psychiatry
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19765
[Journal Article] Major depressive disorder-associated SIRT1 locus affects the risk for suicide in women after middle age.2019
- Author(s)
  Hirata T, Otsuka I, Okazaki S, Mouri K, Horai T, Boku S, Takahashi M, Ueno Y, Sora I, Shirakawa O, Hishimoto A.
- Journal Title
  
  Psychiatry Res
  
  Volume: 278 Pages: 141-145
- DOI
  10.1016/j.psychres.2019.06.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07599, KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-18K15484, KAKENHI-PROJECT-17H04249
[Journal Article] Investigation of chromosome Y loss in men with schizophrenia.2018
- Author(s)
  Hirata T, Hishimoto A, Otsuka I, Okazaki S, Boku S, Kimura A, Horai T, Sora I.
- Journal Title
  
  Neuropsychiatr Dis Treat.
  
  Volume: 14 Pages: 2115-2122
- DOI
  10.2147/ndt.s172886
- NAID
  120006510199
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-18K15484, KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-16K19765, KAKENHI-PROJECT-16H06276
[Journal Article] Mitochondrial DNA copy number of peripheral blood in bipolar disorder: The present study and a meta-analysis.2018
- Author(s)
  Yamaki N, Otsuka I, Numata S, Yanagi M, Mouri K, Okazaki S, Boku S, Horai T, Ohmori T, Shirakawa O, Sora I, Hishimoto A.
- Journal Title
  
  Psychiatry Research
  
  Volume: 269 Pages: 115-117
- DOI
  10.1016/j.psychres.2018.08.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07599, KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-18K15484, KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-16K19765
[Journal Article] Loss of chromosome Y in blood, but not in brain, of suicide completers2018
- Author(s)
  Kimura A, Hishimoto A, Otsuka I, Okazaki S, Boku S, Horai T, Izumi T, Takahashi M, Ueno Y, Shirakawa O, Sora I
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 1 Pages: e0190667-e0190667
- DOI
  10.1371/journal.pone.0190667
- NAID
  120006382347
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-15K19727, KAKENHI-PROJECT-16K10183, KAKENHI-PROJECT-16K19765, KAKENHI-PROJECT-16H06276
[Journal Article] Association of CYP2D6 polymorphisms and extrapyramidal symptoms in schizophrenia patients receiving risperidone: a retrospective study.2018
- Author(s)
  Ito T, Yamamoto K, Ohsawa F, Otsuka I, Hishimoto A, Sora I, Hirai M, Yano I.
- Journal Title
  
  Journal of Pharmaceutical Health Care and Sciences
  
  Volume: 4 Issue: 1 Pages: 28-28
- DOI
  10.1186/s40780-018-0126-y
- NAID
  120006543322
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-16K08400, KAKENHI-PROJECT-16K08401, KAKENHI-PROJECT-16K19765
[Journal Article] Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population.2018
- Author(s)
  Zhang Y, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Yamamori H, Boku S, Horai T, Someya T, Ohmori T, Hashimoto R, Sora I.
- Journal Title
  
  J Psychiatr Res
  
  Volume: 103 Pages: 161-166
- DOI
  10.1016/j.jpsychires.2018.05.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0022, KAKENHI-PROJECT-18K15484, KAKENHI-PROJECT-16H05375, KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-16K15554, KAKENHI-PROJECT-16K19765, KAKENHI-PROJECT-26293261
[Journal Article] A cross-sectional study exploring useful indicators for low bone mineral density in male alcoholic patients.2018
- Author(s)
  Horai T, Hishimoto A, Otsuka I, So T, Mouri K, Shimmyo N, Boku S, Okishio N, Sora I.
- Journal Title
  
  Neuropsychiatric Disease and Treatment
  
  Volume: 14 Pages: 663-669
- DOI
  10.2147/ndt.s153360
- NAID
  120006425682
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07599, KAKENHI-PROJECT-16H06276
[Journal Article] Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia.2018
- Author(s)
  Okazaki S, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Boku S, Shimmyo N, Kinoshita M, Inoue E, Ohmori T, Someya T, Sora I.
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry.
  
  Volume: 83 Pages: 33-41
- DOI
  10.1016/j.pnpbp.2018.01.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19727, KAKENHI-PROJECT-17K16371, KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-16K19765, KAKENHI-PROJECT-16H06276
[Presentation] 自殺既遂者におけるMAOA遺伝子プロモーター領域のミニサテライト多型の関連解析とメタアナリシス2023
- Author(s)
  谷藤貴紀, 長谷川雅史, 岡崎賢志, 大塚郁夫 ,白井寿行, 蓬莱政, 高橋玄倫，上野易弘，毛利健太郎，菱本明豊
- Organizer
  日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-21K07545
[Presentation] 日本人統合失調症患者由来の血液試料を用いたエピジェネティクス的年齢の解析2022
- Author(s)
  岡﨑賢志、大塚郁夫、沼田周助、蓬莱政、毛利健太朗、朴秀賢、大森哲郎、曽良一郎、菱本明豊
- Organizer
  第44回日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-21K07545
[Presentation] ゲノム/エピゲノム解析からみた自殺と細胞老化2022
- Author(s)
  大塚郁夫
- Organizer
  BPCNPNPPP4学会合同年会（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-21K15712
[Presentation] ゲノム/エピゲノム解析からみた自殺と細胞老化2022
- Author(s)
  大塚郁夫
- Organizer
  BPCNPNPPP4学会合同年会(東京)
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0194
[Presentation] 日本人自殺者のゲノムワイド関連解析2021
- Author(s)
  大塚郁夫
- Organizer
  第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-21K15712
[Presentation] 日本人自殺者のゲノムワイド関連解析2021
- Author(s)
  大塚郁夫, 菱本明豊.
- Organizer
  第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-21H02852
[Presentation] 日本人自殺者のゲノムワイド関連解析2021
- Author(s)
  大塚郁夫, 菱本明豊.
- Organizer
  第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-20KK0194
[Presentation] Mir-19b is increased in peripheral blood of schizophenic patients and a!ects proliferation and survival of hippocampal neural progenitor cells2019
- Author(s)
  S. BOKU, T. HORAI, S. OKAZAKI, I. OTSUKA, K. MOURI, A. HISHIMOTO;
- Organizer
  NEUROSCIENCE2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07599
[Presentation] Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia.2018
- Author(s)
  Okazaki S, Otsuka I, Watanabe Y, Numata S, Boku S, Shimmyo N, Ohmori T, Someya T, Sora I, Hishimoto A.
- Organizer
  WFSBP Asia Pacific Regional Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19765
[Presentation] Mitochondrial DNA copy number of peripheral blood in bipolar disorder:the present study and a meta-analysis2018
- Author(s)
  Naruhisa Yamaki, Ikuo Otsuka, Kentaro Mouri, Shuken Boku, Shunsuke Numata, Masaya Yanagi, Tetsuro Ohmori, Osamu Shirakawa, Ichiro Sora, Akitoyo Hishimoto
- Organizer
  WFSBP Asia Pacific Regional Congress of Biological Psychiatry 2018 KOBE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07599
[Presentation] Mosaic loss of chromosome Y in peripheral blood and its risk variants in men with schizophrenia.2018
- Author(s)
  Hirata T, Okazaki S, Otsuka I, Boku S, Aoyama S, Eguchi N, Kimura A, Horai T, Sora I, Hishimoto A.
- Organizer
  WFSBP Asia Pacific Regional Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19765
[Presentation] The cell cycle-related genes as biomarkers for schizophrenia.2018
- Author(s)
  Okazaki S, Boku S, Otsuka I, Eguchi N, Sora I, Hishimoto A.
- Organizer
  Neuroscience 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19765

1. Hishimoto Akitoyo (50529526)

# of Collaborated Projects: 5 results

# of Collaborated Products: 28 results
2. Mouri Kentaro (00642125)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. 高橋健太郎 (30379367)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 秋山雅人 (10757686)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 寺尾知可史 (60610459)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 朴秀賢 (60455665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. LIU XIAOXI (20709216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 曳野圭子 (10789580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山本泰司 (00324921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 足立祥 (30827001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 古屋敷智之 (20362478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 岡崎賢志 (70722867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
13. 蓬莱政 (90817826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
14. IZUMI Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. TODA Shigenobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 江川純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 曽良一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 白河治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 松本純弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 橋本亮太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OTSUKA IKUO 大塚 郁夫

Otsuka Ikuo 大塚 郁夫

Research Projects

Research Products

Co-Researchers

若者を自殺に追い込む生物学的異常と可逆性：エピゲノム・シングルセルダイナミクス

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetic pathomechanisms of accelerated aging in schizophrenia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation for genetic suicide risk and suicide-related aberrant somatic mosaicism through GWASPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prediction and elucidation for suicide risk using polygenic risk score analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of biomarker for youth suicide risk through blood telomere length

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of biomarker for youth suicide risk through genome and epigenome-wide dataPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A worldwide study of genetic factor for suicide

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of suicide risk markers for young people focusing on telomere length

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of aberrant methylation on CpG island of X chromosome in male schizophreniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 不安と自殺・自傷 ー特に遺伝学的知見の観点からー（臨床精神医学）2022

Author(s)

Total Pages

Publisher

Data Source

[Book] 臨床での活用が期待される自殺の生物学的知見（別冊・医学のあゆみ）2022

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Association study of a single nucleotide polymorphism in the hypoxia response element of the macrophage migration inhibitory factor gene promoter with suicide completers in the Japanese population2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relationship of Major Depressive Disorder and Schizophrenia Polygenic Risk Scores to Suicide: A Comparison Between European and Asian Ancestry Populations2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenome‐wide association study on methamphetamine dependence2024

OTSUKA IKUO 大塚郁夫

Otsuka Ikuo 大塚郁夫

[Book] 不安と自殺・自傷ー特に遺伝学的知見の観点からー（臨床精神医学）2022