BOKU Shuken 朴秀賢

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Boku Shuken 朴秀賢

BOKU Syuken 朴秀賢

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Researcher Number	60455665
Other IDs
Affiliation (Current)	2025: 新潟大学, 医歯学系, 教授
Affiliation (based on the past Project Information) *help	2025: 新潟大学, 医歯学系, 教授 2019 – 2024: 熊本大学, 大学院生命科学研究部(医), 准教授 2016 – 2020: 神戸大学, 医学研究科, 講師 2017: 神戸大学, 大学院医学研究科精神医学分野, 講師 2015: 神戸大学, 医学(系)研究科(研究院), 講師 … More 2013: 北海道大学, 大学院医学研究科, 助教 2011 – 2013: 北海道大学, 大学病院, 助教 2011: 北海道大学, 北海道大学病院, 助教 2010: 北海道大学, 病院, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science Except Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science
Keywords	Principal Investigator 成体海馬神経細胞新生 / うつ病 / 海馬 / miRNA / DNAメチル化 / 幼少期ストレス / 気分障害 / アストロサイト / 電気けいれん療法 / マイクロRNA … More / 母子分離ストレス / DNMT / ROCK / β-catenin / GSK-3β / FGF … More Except Principal Investigator うつ病 / 神経栄養因子 / 自殺 / 発生・分化 / 脳神経疾患 / 神経幹細胞 / 抗うつ薬 / LPA1受容体 / バイアス型アゴニスト / 患者層別化 / リゾリン脂質 / 創薬 / 層別化 / リゾフォスファチジン酸受容体１ / リゾリン脂質代謝 / 全RNA解析 / アセチルコリン / ミクログリア / 成体海馬神経細胞新生 / 間歇型一酸化炭素中毒 / 脳組織 / 血漿 / L体 / D体 / アミノ酸 / うつ病モデルマウス / L体アミノ酸 / 血液 / モデル動物 / D体アミノ酸 / テロメア長 / 若年者 / BDNF / エピジェネティクス / 学習性無力 / 拘束ストレス / 母子分子ストレス / サイトカイン / FKBP5 / 母子分離ストレス / 環境富化 / PTSD / 神経科学 / ストレス / テロメア短縮 / バイオマーカー / DNAメチル化 / ミトコンドリア / テロメア / 精神疾患 / Sox6 / Otx2 / ドーパミン / DTI / 海馬 / 気分障害 / CaMKIV / グリア細胞 / ドパミン / 気分安定薬 / 神経細胞新生 Less

Elucidating the molecular and cellular mechanisms of emotional behavior modulation by LPAR1-biased agonists
- Principal Investigator
  
  梶谷直人
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kumamoto University
Stratification of depression based on lysophospholipid metabolic disorders and innovative development of novel antidepressants
- Principal Investigator
  
  竹林実
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kumamoto University
間歇型一酸化炭素中毒の病態解明及び治療の究明
- Principal Investigator
  
  越智紳一郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Ehime University
海馬アストロサイトに着目した電気けいれん療法の作用機序解明Principal Investigator
- Principal Investigator
  
  朴秀賢
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kumamoto University
Reserach of depression focusing on D-amino acids
- Principal Investigator
  
  NUMATA Shusuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  The University of Tokushima
Investigation of mood disorders focused on early life stress and miRNAPrincipal Investigator
- Principal Investigator
  
  Boku Shuken
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kumamoto University
  Kobe University
Development of suicide risk markers for young people focusing on telomere length
- Principal Investigator
  
  Mouri Kentaro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kobe University
Stress, depression, and suicide - molecular basis of the downward spiral
- Principal Investigator
  
  Hishimoto Akitoyo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Yokohama City University
  Kobe University
Analysis of biological model using iPS cells derived from AD/HD individuals
- Principal Investigator
  
  Sora Ichiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Kobe University
Analysis of mesolimbic dopaminergic neuron (A10) induced from patients of mental disorders
- Principal Investigator
  
  Sora Ichiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Kobe University
Epigenetic effects of early life stress on adult hippocampal neurogenesisPrincipal Investigator
- Principal Investigator
  
  Boku Shuken
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Kobe University
The effect of gene-environmental interactions on PTSD
- Principal Investigator
  
  Toda Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  National Defense Medical College
Neural mechanisms underlying stress vulnerability -involvement of neurogenesis in mood disorder
- Principal Investigator
  
  NAKAGAWA shin
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Hokkaido University
Exploration of the new therapeutic target molecule for treatmentresistant mood disorders through elucidation of the molecular mec hanism of adult hippocampal neurogenesisPrincipal Investigator
- Principal Investigator
  
  BOKU Syuken
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Hokkaido University

All 2024 2023 2022 2020 2019 2018 2014 2013 2012 2011 2010

All Journal Article Presentation Book

[Book] ラット母子分離ストレスによる成獣後の不安行動への脆弱性の分子メカニズム. 気分障害の薬理・生化学2012
- Author(s)
  戸田裕之、朴　秀賢、中川　伸、小山　司
- Publisher
  医薬ジャーナル誌
- Data Source
  KAKENHI-PROJECT-23591667
[Book] 気分安定薬と成体海馬歯状回神経細胞新生.気分障害の薬理・生化学-総括と新たなる挑戦-2012
- Author(s)
  朴秀賢
- Publisher
  医薬ジャーナル
- Data Source
  KAKENHI-PROJECT-22791102
[Journal Article] TCF7L2: A potential key regulator of antidepressant effects on hippocampal astrocytes in depression model mice2024
- Author(s)
  Koga Yusaku、Kajitani Naoto、Miyako Kotaro、Takizawa Hitoshi、Boku Shuken、Takebayashi Minoru
- Journal Title
  
  Journal of Psychiatric Research
  
  Volume: 170 Pages: 375-386
- DOI
  10.1016/j.jpsychires.2024.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07501, KAKENHI-PROJECT-23K27530
[Journal Article] Identification of the antidepressant effect of electroconvulsive stimulation-related genes in hippocampal astrocyte2024
- Author(s)
  Miyako K, Kajitani N, Koga Y, Takizawa H, Boku S, Takebayashi M
- Journal Title
  
  J Psychiatr Res
  
  Volume: 170 Pages: 318-327
- DOI
  10.1016/j.jpsychires.2024.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07599, KAKENHI-PROJECT-21K07501, KAKENHI-PROJECT-23K27530
[Journal Article] G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression.2024
- Author(s)
  Kajitani, N., Okada-Tsuchioka, M., Inoue, A., Miyano, K., Masuda, T., Boku, S., Iwamoto, K., Ohtsuki, S., Uezono, Y., Aoki, J., Takebayashi, M.
- Journal Title
  
  Neuropsychopharmacology
  
  Volume: 49 Issue: 3 Pages: 561-572
- DOI
  10.1038/s41386-023-01727-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07750, KAKENHI-PROJECT-21K07501, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-23K27530
[Journal Article] Serum levels of high mobility group box‐1 protein (<scp>HMGB1</scp>) and soluble receptors of advanced glycation end‐products (<scp>RAGE</scp>) in depressed patients treated with electroconvulsive therapy2023
- Author(s)
  Abe Hiromi、Okada‐Tsuchioka Mami、Kajitani Naoto、Omori Wataru、Itagaki Kei、Shibasaki Chiyo、Boku Shuken、Matsuhisa Tetsuaki、Takebayashi Minoru
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 43 Issue: 3 Pages: 359-364
- DOI
  10.1002/npr2.12358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07501, KAKENHI-PROJECT-23K27530
[Journal Article] miR-19b is elevated in peripheral blood of schizophrenic patients and attenuates proliferation of hippocampal neural progenitor cells2020
- Author(s)
  Horai T, Boku S, Okazaki S, Otsuka I, Ratta-Apha W, Mouri K, Yamaki N, Hirata T, Hishimoto A.
- Journal Title
  
  J Psychiatr Res .
  
  Volume: 131 Pages: 102-107
- DOI
  10.1016/j.jpsychires.2020.09.006
- NAID
  120006952760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0194, KAKENHI-PROJECT-18K07599, KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-18K15484
[Journal Article] Chemokine Alterations in the Postmortem Brains of Suicide Completers2020
- Author(s)
  Shinko Y, Otsuka I, Okazaki S, Horai T, Boku S, Takahashi M, Ueno Y, Sora I, Hishimoto A.
- Journal Title
  
  J Psychiatr Res .
  
  Volume: 120 Pages: 29-33
- DOI
  10.1016/j.jpsychires.2019.10.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-18K15484, KAKENHI-PROJECT-17H04249
[Journal Article] ATP and Repetitive Electric Stimulation Increases Leukemia Inhibitory Factor Expression in Astrocytes: A Potential Role for Astrocytes in the Action Mechanism of Electroconvulsive Therapy2020
- Author(s)
  Maruyama S, Boku S, Okazaki S, Kikuyama H, Mizoguchi Y, Monji A, Otsuka I, Sora I, Kanazawa T, Hishimoto A, Yoneda H.
- Journal Title
  
  Psychiatry Clin Neurosci .
  
  Volume: . Issue: 5 Pages: 12986-12986
- DOI
  10.1111/pcn.12986
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-17K10275
[Journal Article] Accelerated Extrinsic Epigenetic Aging and Increased Natural Killer Cells in Blood of Suicide Completers2020
- Author(s)
  Okazaki S, Otsuka I, Horai T, Hirata T, Takahashi M, Ueno Y, Boku S, Sora I, Hishimoto A.
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry .
  
  Volume: 98 Pages: 109805-109805
- DOI
  10.1016/j.pnpbp.2019.109805
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-18K15484, KAKENHI-PROJECT-17H04249
[Journal Article] Epigenetic clock analysis of blood samples from Japanese schizophrenia patients.2019
- Author(s)
  Okazaki S, Otsuka I, Numata S, Horai T, Mouri K, Boku S, Ohmori T, Sora I, Hishimoto A.
- Journal Title
  
  NPJ Schizophrenia
  
  Volume: 5 Issue: 1 Pages: 4-4
- DOI
  10.1038/s41537-019-0072-1
- NAID
  120006629323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07599, KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-18K15484, KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-16K19765, KAKENHI-PROJECT-18H02751
[Journal Article] Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population.2019
- Author(s)
  Otsuka I, Akiyama M, Shirakawa O, Okazaki S, Momozawa Y, Kamatani Y, Izumi T, Numata S, Takahashi M, Boku S, Sora I, Yamamoto K, Ueno Y, Toda T, Kubo M, Hishimoto A
- Journal Title
  
  Neuropsychopharmacology
  
  Volume: 44 Issue: 12 Pages: 2119-2124
- DOI
  10.1038/s41386-019-0506-5
- NAID
  120007027666
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08079, KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-17H04249
[Journal Article] Major depressive disorder-associated SIRT1 locus affects the risk for suicide in women after middle age.2019
- Author(s)
  Hirata T, Otsuka I, Okazaki S, Mouri K, Horai T, Boku S, Takahashi M, Ueno Y, Sora I, Shirakawa O, Hishimoto A.
- Journal Title
  
  Psychiatry Res
  
  Volume: 278 Pages: 141-145
- DOI
  10.1016/j.psychres.2019.06.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07599, KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-18K15484, KAKENHI-PROJECT-17H04249
[Journal Article] Investigation of chromosome Y loss in men with schizophrenia.2018
- Author(s)
  Hirata T, Hishimoto A, Otsuka I, Okazaki S, Boku S, Kimura A, Horai T, Sora I.
- Journal Title
  
  Neuropsychiatr Dis Treat.
  
  Volume: 14 Pages: 2115-2122
- DOI
  10.2147/ndt.s172886
- NAID
  120006510199
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-18K15484, KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-16K19765, KAKENHI-PROJECT-16H06276
[Journal Article] Mitochondrial DNA copy number of peripheral blood in bipolar disorder: The present study and a meta-analysis.2018
- Author(s)
  Yamaki N, Otsuka I, Numata S, Yanagi M, Mouri K, Okazaki S, Boku S, Horai T, Ohmori T, Shirakawa O, Sora I, Hishimoto A.
- Journal Title
  
  Psychiatry Research
  
  Volume: 269 Pages: 115-117
- DOI
  10.1016/j.psychres.2018.08.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07599, KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-18K15484, KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-16K19765
[Journal Article] Loss of chromosome Y in blood, but not in brain, of suicide completers2018
- Author(s)
  Kimura A, Hishimoto A, Otsuka I, Okazaki S, Boku S, Horai T, Izumi T, Takahashi M, Ueno Y, Shirakawa O, Sora I
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 1 Pages: e0190667-e0190667
- DOI
  10.1371/journal.pone.0190667
- NAID
  120006382347
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-15K19727, KAKENHI-PROJECT-16K10183, KAKENHI-PROJECT-16K19765, KAKENHI-PROJECT-16H06276
[Journal Article] Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population.2018
- Author(s)
  Zhang Y, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Yamamori H, Boku S, Horai T, Someya T, Ohmori T, Hashimoto R, Sora I.
- Journal Title
  
  J Psychiatr Res
  
  Volume: 103 Pages: 161-166
- DOI
  10.1016/j.jpsychires.2018.05.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0022, KAKENHI-PROJECT-18K15484, KAKENHI-PROJECT-16H05375, KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-16K15554, KAKENHI-PROJECT-16K19765, KAKENHI-PROJECT-26293261
[Journal Article] A cross-sectional study exploring useful indicators for low bone mineral density in male alcoholic patients.2018
- Author(s)
  Horai T, Hishimoto A, Otsuka I, So T, Mouri K, Shimmyo N, Boku S, Okishio N, Sora I.
- Journal Title
  
  Neuropsychiatric Disease and Treatment
  
  Volume: 14 Pages: 663-669
- DOI
  10.2147/ndt.s153360
- NAID
  120006425682
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07599, KAKENHI-PROJECT-16H06276
[Journal Article] Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia.2018
- Author(s)
  Okazaki S, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Boku S, Shimmyo N, Kinoshita M, Inoue E, Ohmori T, Someya T, Sora I.
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry.
  
  Volume: 83 Pages: 33-41
- DOI
  10.1016/j.pnpbp.2018.01.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19727, KAKENHI-PROJECT-17K16371, KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-16K19765, KAKENHI-PROJECT-16H06276
[Journal Article] The effect of dopamine on adult hippocampal neurogenesis2014
- Author(s)
  Takamura N, Nakagawa S, Masuda T,Boku S, Kato A, Song N, An Y, Kitaichi Y, Inoue T, Koyama T, Kusumi I
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry
  
  Volume: 50 Pages: 116-124
- DOI
  10.1016/j.pnpbp.2013.12.011
- NAID
  120005411146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591667, KAKENHI-PROJECT-24591673
[Journal Article] Tricyclic antidepressant amitriptyline indirectly increases the proliferation of adult dentate gyrus-derived neural precursors : an involvement of astrocytes.2013
- Author(s)
  Boku S, Hisaoka-Nahashima K, Nakagawa S, Kato A, Kaiitani N, Inoue T, Kusumi I, Takebayashi M
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 11 Pages: 116-124
- DOI
  10.1371/journal.pone.0079371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06852, KAKENHI-PROJECT-23591667, KAKENHI-PROJECT-23591686, KAKENHI-PROJECT-24591673, KAKENHI-PROJECT-25870461
[Journal Article] GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT32013
- Author(s)
  Boku S, Nakagawa S, Takamura N,Kato A, Takebayashi M, Hisaoka-Nakashima K, Omiya Y,Inoue T, Kusumi I
- Journal Title
  
  Biochem. Biophys Res Commun
  
  Volume: 434 Issue: 4 Pages: 779-784
- DOI
  10.1016/j.bbrc.2013.04.011
- NAID
  120005460238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591667, KAKENHI-PROJECT-24591673
[Journal Article] ROCK2 regulates bFGF-induced proliferation of SH-SY5Y cells through GSK-3β and β-catenin pathway.2013
- Author(s)
  Boku S, Nakagawa S, Toda H, Kato A, Takamura N, Omiya Y, Inoue T, Koyama T
- Journal Title
  
  Brain research
  
  Volume: 1492 Pages: 7-17
- DOI
  10.1016/j.brainres.2012.11.034
- NAID
  120005228253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591667, KAKENHI-PROJECT-24591673
[Journal Article] Involvement of CaMKIV in neurogenic effect with chronic fluoxetine treatment2013
- Author(s)
  Song N, Nakagawa S, Izumi T, Toda H, Kato A, Boku S, Inoue T, Sakagami H, Li X, Koyama T
- Journal Title
  
  Int J Neuropsychopharmacol
  
  Volume: 16(4) Issue: 4 Pages: 803-812
- DOI
  10.1017/s1461145712000570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300114, KAKENHI-PROJECT-23591667, KAKENHI-PROJECT-24591673, KAKENHI-PROJECT-25640025
[Journal Article] Valproate recovers the inhibitory effect of dexamethasone on the proliferation of the adult dentate gyrus-derived neural precursor cells via GSK-3β and β-catenin pathway2013
- Author(s)
  Boku S, Nakagawa S, Masuda T, Nishikawa H, Kato A, Takamura N, Omiya Y, Kitaichi Y, Inoue T, Kusuimi I
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 723 Pages: 425-430
- DOI
  10.1016/j.ejphar.2013.10.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591667, KAKENHI-PROJECT-24591673
[Journal Article] Involvement of CaMKIV in neurogenic effect with chronic fluoxetine treatment2012
- Author(s)
  Song N, Nakagawa S, Izumi T, Toda H, Kato A, Boku S, Inoue T, Sakagami H, Li X, Koyama T
- Journal Title
  
  Int J Neuropsychopharmacology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791102
[Journal Article] Effect of triiodothyronine (T(3)) augmentation of acute milnacipran administration on monoamine levels: an in vivo microdialysis study in rats.2012
- Author(s)
  Kitaichi Y, Inoue T, Nakagawa S, Boku S, Kato A, Kusumi I, Koyama T
- Journal Title
  
  Neuropsychiatric disease and treatment
  
  Volume: 8 Pages: 501-507
- DOI
  10.2147/ndt.s36906
- NAID
  120004979568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591667, KAKENHI-PROJECT-24591673
[Journal Article] Mood stabilizers commonly restore staurosporine-induced increase of p53 expression and following decrease of Bcl-2 expression in SH-SY5Y cells2012
- Author(s)
  Song N, Boku S, Nakagawa S, Kato A, Toda H, Takamura N, Omiya Y, Kitaichi Y, Inoue T, Koyama T
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry, Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791102
[Journal Article] prevents the anxiolytic-like effect of citalopram in rat contextual conditioned fear stress model2012
- Author(s)
  Masuda T, Nishikawa H, Inoue T, Toda H, Nakagawa S, Boku S, Koyama T
- Journal Title
  
  Acta Neuropsychiatr. Accepted manuscript online
  
  Volume: 25 Issue: 2 Pages: 77-84
- DOI
  10.1111/j.1601-5215.2012.00669.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591478, KAKENHI-PROJECT-22791102
[Journal Article] Mood stabilizers commonly restore staurosporine-induced increase of p53 expression and following decrease of Bcl-2 expression in SH-SY5Y cells2012
- Author(s)
  Song N, et al.
- Journal Title
  
  Prog Neuropsychophamacol Biol Psychiatry
  
  Volume: (in press) Issue: 2 Pages: 183-189
- DOI
  10.1016/j.pnpbp.2012.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591478, KAKENHI-PROJECT-22791102, KAKENHI-PROJECT-23591667
[Journal Article] Effects of combined treatment with clorgyline and selegiline on extracellular noradrenaline and serotonin levels. Acta Neuropsychiatr2012
- Author(s)
  Kitaichi Y, Inoue T, Nakagawa S, Boku S and Koyama T
- Journal Title
  
  Accepted manuscript online
  
  Volume: (in press) Issue: 6 Pages: 369-373
- DOI
  10.1111/j.1601-5215.2012.00652.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591478, KAKENHI-PROJECT-22791102
[Journal Article] Noradrenaline increases neural precursor cells derived from adult rat dentate gyrus through beta2 receptor2012
- Author(s)
  Masuda T, et al.
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry
  
  Volume: 36 Issue: 1 Pages: 44-51
- DOI
  10.1016/j.pnpbp.2011.08.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591478, KAKENHI-PROJECT-23591667
[Journal Article] Noradrenaline increases neural precursor cells derived from adult rat dentate gyrus through beta2 receptor2012
- Author(s)
  Masuda T, Nakagawa S, Boku S, Nishikawa H, Takamura N, Kato A, Inoue T, Koyama T
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry
  
  Volume: 36 Pages: 44-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791102
[Journal Article] Sertraline treatment of patients with major depressive disorder who failed initial treatment with paroxetine or fluvoxamine2012
- Author(s)
  Inoue T, Honda M, Kawamura K, Tsuchiya K, Suzuki T, Ito K, Matsubara R, Shinohara K, Ishikane T, Sasaki K, Boku S, Fujisawa D, Ono Y, Koyama T
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry
  
  Pages: 22504727-22504727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791102
[Journal Article] Effects of mood stabilizers on adult dentate gyrus-derived neural precursor cells2011
- Author(s)
  Boku S, Nakagawa S, Masuda T, Nishikawa S, Kato A, Toda H, Song N, Kitaichi Y, Inoue T, Koyama T
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry
  
  Volume: 35 Pages: 111-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791102
[Journal Article] Effects of mood stabilizers on adult dentate gyrus-derived neural precursor cells2011
- Author(s)
  Boku S, Nakagawa S, Masuda T,Nishikawa H, Kato A, Toda H, Song N, Kitaichi Y, Inoue T, Koyama T
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry
  
  Volume: 35 Issue: 1 Pages: 111-117
- DOI
  10.1016/j.pnpbp.2010.09.019
- NAID
  120004856983
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591667
[Journal Article] Retrieval of conditioned fear activates the basolateral and intercalated nucleus of amygdala2011
- Author(s)
  Izumi T, Boku S, Shinmin W, Inoue T, Konno K, Yamaguchi T, Yoshida T, Matsumoto M, Watanabe M, Koyama T, Yoshioka M
- Journal Title
  
  J Neurosci Res
  
  Volume: 89(5) Pages: 773-790
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791102
[Journal Article] Effects of mood stabilizers on adult dentate gyrus-derived neural precursor cells2011
- Author(s)
  Boku S, Nakagawa S, Masuda T, et al
- Journal Title
  
  Progress in Neuro-Psychopharmacology and Biological Psychiatry
  
  Volume: 35 Pages: 111-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791102
[Journal Article] Olanzapine augmentation of milnacipran for stage 2 treatment-resistant major depression an open study2011
- Author(s)
  Boku S, Inoue T, Honma H, Matsubara S, Nakagawa S, Koyama T
- Journal Title
  
  Hum Psychopharmacol
  
  Volume: 26 Pages: 237-241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791102
[Journal Article] Olanzapine augmentation of milnacipran for stage 2 treatment-resistant major depression2011
- Author(s)
  Boku S, Inoue T, Honma H, et al
- Journal Title
  
  Hum Psychopharmacol
  
  Volume: 26 Issue: 3 Pages: 237-241
- DOI
  10.1002/hup.1197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791102
[Journal Article] Long-term naturalistic follow-up of lithium augmentation : Relevance to bipolarity2011
- Author(s)
  Inoue T, Abekawa T, Nakagawa S, Suzuki K, Tanaka T, Kitaichi Y, Boku S, Nakato Y, Toda H, Koyama T
- Journal Title
  
  J Affect Disord
  
  Volume: 129 Issue: 1-3 Pages: 64-67
- DOI
  10.1016/j.jad.2010.08.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791102, KAKENHI-PROJECT-23591667
[Journal Article] Glucocorticoids and Lithium in Adult Hippocampal Neurogenesis2010
- Author(s)
  Boku S, Nakagawa S, Koyama T
- Journal Title
  
  Vitamins and Hormones
  
  Volume: 82 Pages: 421-431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791102
[Journal Article] Sertraline increases extracellular levels not only of serotonin, but also of dopamine in the nucleus accumbens and striatum of rats2010
- Author(s)
  Kitaichi Y, Inoue T, Nakagawa S, Boku S, Kakuta A, Izumi T, Koyama T
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 647 Pages: 90-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791102
[Presentation] 三環系抗うつ薬はGタンパク質バイアス型LPA1受容体作動薬として抗うつ効果に関与する2023
- Author(s)
  梶谷直人，岡田麻美，朴秀賢，竹林実
- Organizer
  第45回日本生物学的精神医学会年会
- Data Source
  KAKENHI-PROJECT-23K27530
[Presentation] Identification of anti-depressive effects of electroconvulsive stimulation-related genes in hippocampal astrocytes2023
- Author(s)
  Boku S, Miyako K, Kajitani N, Koga Y, Takebayashi M
- Organizer
  American Congress of Neuropsychopharmacology annual meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07599
[Presentation] Establishment of a clinical setting-associated behavioral model of ECT and investigation of the mechanism of action of ECT with focus on astrocytes2022
- Author(s)
  Kotaro Miyako, Naoto Kajitani, Yusaku Koga, Shuken Boku, Minoru Takebayashi
- Organizer
  Society of Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07599
[Presentation] Mir-19b is increased in peripheral blood of schizophenic patients and a!ects proliferation and survival of hippocampal neural progenitor cells2019
- Author(s)
  S. BOKU, T. HORAI, S. OKAZAKI, I. OTSUKA, K. MOURI, A. HISHIMOTO;
- Organizer
  NEUROSCIENCE2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07599
[Presentation] Mitochondrial DNA copy number of peripheral blood in bipolar disorder:the present study and a meta-analysis2018
- Author(s)
  Naruhisa Yamaki, Ikuo Otsuka, Kentaro Mouri, Shuken Boku, Shunsuke Numata, Masaya Yanagi, Tetsuro Ohmori, Osamu Shirakawa, Ichiro Sora, Akitoyo Hishimoto
- Organizer
  WFSBP Asia Pacific Regional Congress of Biological Psychiatry 2018 KOBE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07599
[Presentation] The cell cycle-related genes as biomarkers for schizophrenia.2018
- Author(s)
  Okazaki S, Boku S, Otsuka I, Eguchi N, Sora I, Akitoyo Hishimoto A.
- Organizer
  Neuroscience 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04249
[Presentation] Mitochondrial DNA copy number of peripheral blood in bipolar disorder:the present study and a meta-analysis.2018
- Author(s)
  Yamaki N, Otsuka I, Mouri K, Boku S, Numata S, Yanagi M, Ohmori T, Shirakawa O, Sora I, Hishimoto A.
- Organizer
  WFSBP Asia Pacific Regional Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04249
[Presentation] Mosaic loss of chromosome Y in peripheral blood and its risk variants in men with schizophrenia.2018
- Author(s)
  Hirata T, Okazaki S, Otsuka I, Boku S, Aoyama S, Eguchi N, Kimura A, Horai T, Sora I, Hishimoto A.
- Organizer
  WFSBP Asia Pacific Regional Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04249
[Presentation] Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia.2018
- Author(s)
  Okazaki S, Otsuka I, Watanabe Y, Numata S, Boku S, Shimmyo N, Ohmori T, Someya T, Sora I, Hishimoto A.
- Organizer
  WFSBP Asia Pacific Regional Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04249
[Presentation] Effect of dopamine on adulthippocampal neurogenesis2013
- Author(s)
  Nakagawa. S, Takamura. N, Boku. S,Song. N, Kato. A, Inoue. T, Kusumi. I
- Organizer
  第11回世界生物学的精神医学会国際会議
- Place of Presentation
  国立京都国際会館(京都市)
- Data Source
  KAKENHI-PROJECT-23591667
[Presentation] Effect of dopamine on adult hippocampal neurogenesis.2013
- Author(s)
  Nakagawa S, Takamura N, Boku S, Song N, Inoue T, Kusumi I
- Organizer
  第11回世界生物学的精神医学会国際会議
- Place of Presentation
  国立京都国際会議場（京都）
- Data Source
  KAKENHI-PROJECT-23591667
[Presentation] Effect of dopamine on adult hippocampal neurogenesis.2012
- Author(s)
  Nakagawa S, Takamura N, Boku S, Song N, Kato A, Inoue T
- Organizer
  42th Annual Meeting Society for Neuroscience
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-23591667
[Presentation] Effect of dopamine on adult hippocampal neurogenesis2012
- Author(s)
  Nakagawa. S, Takamura. N, Boku. S,Song. N, Kato. A, Inoue. T
- Organizer
  42th Annual Meeting Society for Neuroscience
- Place of Presentation
  New Orleans Convention Center (New Orleans,USA)
- Data Source
  KAKENHI-PROJECT-23591667
[Presentation] 抗うつ薬未服用のうつ病患者における脳拡散テンソル画像2011
- Author(s)
  中川　伸、Khin Khin Tha、井上　猛、仲唐安哉、北川信樹、賀古勇輝、戸田裕之、朴秀賢、亀山梨絵、寺江　聡、小山　司
- Organizer
  第30回躁うつ病の薬理・生化学的研究懇話会
- Place of Presentation
  京都ガーデンパレス(京都府）
- Data Source
  KAKENHI-PROJECT-23591667
[Presentation] Involvement of CaM kinase IV in the action of antidepressant treatment2011
- Author(s)
  Shin Nakagawa, Ning Song, Takeshi Izumi, Shuken Boku, Hiroyuki Toda, Akiko Kato, Xiaobai Li, Takeshi Inoue, Hiroyuki Sakagami, Tsukasa Koyama
- Organizer
  41th Annual Meeting Society for Neuroscience
- Place of Presentation
  Washington Convention Center (Washington DC, USA)
- Data Source
  KAKENHI-PROJECT-23591667
[Presentation] Involvement of CaM kinase IV in the action of antidepressant treatment2011
- Author(s)
  Shin Nakagawa, Ning Song, Takeshi Izumi, Shuken Boku, Hiroyuki Toda, Akiko Kato, Xiaobai Li, Takeshi Inoue, Hiroyuki Sakagami, Tsukasa Koyama
- Organizer
  Society for Neuroscience 41th annual meeting
- Place of Presentation
  Walter E.Washington Convention Center (USA)
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-22791102
[Presentation] Involvement of CaM kinase IV in the action of antidepressant treatment2011
- Author(s)
  Nakagawa. S, Song. N, Izumi. T,Boku. S, Toda. H, Kato. A, Li. X, Inoue.T, Sakagami. H, Koyama. T
- Organizer
  41th Annual Meeting Society for Neuroscience
- Place of Presentation
  Washington DCConvention Center (Washington DC,USA)
- Data Source
  KAKENHI-PROJECT-23591667
[Presentation] 抗うつ薬未服用のうつ病患者における脳拡散テンソル画像2011
- Author(s)
  中川伸、Khin Khin Tha、井上猛、仲唐安哉、北川信樹、賀古勇輝、戸田裕之、朴秀賢、亀山梨絵、寺江聡、小山司
- Organizer
  第30回躁うつ病の薬理・生化学的研究懇話会
- Place of Presentation
  京都ガーデンパレス(京都)
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-22791102
[Presentation] Rho-associated coiled-coil kinase (ROCK2) regulates bFGF-induced proliferation of SH-SY5Y cells through GSK-3β and β-catenin pathway2011
- Author(s)
  Boku S, et al.
- Organizer
  Society for Neuroscience 41th annual meeting
- Place of Presentation
  Walter E.Washington Convention Center (USA)
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-22791102
[Presentation] Rho-associated coiled-coil kinase(ROCK2) regulates bFGF-induced proliferation of SH-SY5Y cells through GSK-3βandβ-catenin pathway2011
- Author(s)
  Boku S, Nakagawa S, Toda H, et al
- Organizer
  Society for Neuroscience 41^<th> annual meeting
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-22791102
[Presentation] 気分安定薬はSH-SY5Y細胞においてstaurosporineによるp53の発現増加およびBcl-2の発現減少を抑制させる2011
- Author(s)
  朴秀賢、宋寧、中川伸、加藤亜紀子、高村直樹、戸田裕之、井上猛、小山司
- Organizer
  第30回躁うつ病懇話会
- Place of Presentation
  京都(ガーデンホテル京都)
- Data Source
  KAKENHI-PROJECT-22791102
[Presentation] Effects of mood stabilizers on adult dentate gyrus-derived neural precursor cells2010
- Author(s)
  Shuken Boku
- Organizer
  第25回韓国生物学的精神医学会
- Place of Presentation
  ソウル・リッツカールトンホテル(韓国)(招待講演)
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-22791102

1. Hishimoto Akitoyo (50529526)

# of Collaborated Projects: 6 results

# of Collaborated Products: 12 results
2. Toda Hiroyuki (00610677)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. Sora Ichiro (40322713)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. Mouri Kentaro (00642125)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
5. 竹林実 (60304440)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
6. 梶谷直人 (60755742)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
7. Izumi Takeshi (60312360)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. NAKAGAWA shin (60360905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
9. INOUE Takshi (70250438)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
10. Murai Toshiya (30335286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Furuyashiki Tomoyuki (20362478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SUZUKI Go (50649035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NUMATA Shusuke (10403726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 青井貴之 (00546997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 白川治 (40243307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 辻井農亜 (90460914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 丹生谷正史 (00228256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 清水邦夫 (00531641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 大塚郁夫 (40722880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
20. 高橋健太郎 (30379367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 古賀農人 (70744936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 越智紳一郎 (40568911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 西原佑 (50568912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 青木淳賢 (20250219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 岩本和也 (40342753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 服部功太郎 (50415569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 可野邦行 (50636404)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. Hiroi Noboru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. TANICHI Masaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. SAITO Taku

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 岡崎賢志

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
32. 白河治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. 宮野加奈子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 上園保仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 橋本亮太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 阪上洋行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

BOKU Shuken 朴 秀賢

Boku Shuken 朴 秀賢

BOKU Syuken 朴 秀賢

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海馬アストロサイトに着目した電気けいれん療法の作用機序解明Principal Investigator

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Investigation of mood disorders focused on early life stress and miRNAPrincipal Investigator

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Epigenetic effects of early life stress on adult hippocampal neurogenesisPrincipal Investigator

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Exploration of the new therapeutic target molecule for treatmentresistant mood disorders through elucidation of the molecular mec hanism of adult hippocampal neurogenesisPrincipal Investigator

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BOKU Shuken 朴秀賢

Boku Shuken 朴秀賢

BOKU Syuken 朴秀賢