Watanabe Motoki 渡邉元樹

… Alternative Names

渡邉元樹ワタナベモトキ

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Researcher Number	40723581
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師
Affiliation (based on the past Project Information) *help	2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2022 – 2023: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2017 – 2020: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2014 – 2017: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / Hygiene and public health Except Principal Investigator Hygiene and public health
Keywords	Principal Investigator 分子標的癌予防 / がん予防 / ケミカルバイオロジー / cyclin D1 / 食品成分 / がん腫瘍学 / がん予防学 / 天然化合物 / 分子動力学シミュレーション / ケモプロテオミクス … More / ペリリルアルコール / セサミノール / 大腸癌 / 分子標的予防 / コーヒー酸 / PHB2 / RPS5 / コーヒー含有成分 / ribosomal protein S5 / prohibitin2 / カフェ酸 / コーヒー / 大腸がん / サラゾピリン / メバロン酸代謝経路 / グルタチオン代謝経路 / 癌代謝 / スタチン / sulfasalazine / トリプルネガティブ乳癌 / メバロン酸代謝 / statins / MEK阻害剤 / グルタチオン代謝 / salazosulfapyridine / vorinostat / HDAC阻害剤 / ERα陽性乳癌 / chemical biology / troglitazone / perillyl alcohol / sesaminol / breast cancer / ANT2 … More Except Principal Investigator 分子予防 / 抗酸化能 / 飲料 / 抗炎症 / 抗酸化 / 天然物 / RB再活性化 / 分子標的予防法 / がん予防 Less

分子・細胞から集団レベルまでを包括したPFASの発がん性に対する分野横断的研究Principal Investigator
- Principal Investigator
  
  渡邉元樹
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Kyoto Prefectural University of Medicine
Chemoproteomics and molecular dynamics simulation-based drug discovery platforms for chemopreventionPrincipal Investigator
- Principal Investigator
  
  渡邉元樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Kyoto Prefectural University of Medicine
Reserch into the mechanism how coffee prevents colorectal cancer using chemical biology approachPrincipal Investigator
- Principal Investigator
  
  Watanabe Motoki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Kyoto Prefectural University of Medicine
Development of chemoprevention for familial breast cancer focusing on the cancer metabolismPrincipal Investigator
- Principal Investigator
  
  Watanabe Motoki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hygiene and public health
- Research Institution
  Kyoto Prefectural University of Medicine
Application of molecular-targeting cancer prevention to human intervention study.
- Principal Investigator
  
  SAKAI Toshiyuki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hygiene and public health
- Research Institution
  Kyoto Prefectural University of Medicine
The investigation for the critical cause of ERalpha-positive breast cancer and the establishment of its chemoprevention using chemical biologyPrincipal Investigator
- Principal Investigator
  
  Watanabe Motoki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hygiene and public health
- Research Institution
  Kyoto Prefectural University of Medicine

All 2024 2023 2022 2019 2018 2017

All Journal Article Presentation

[Journal Article] Induction of <i>MYCN</i>-amplified neuroblastoma differentiation through NMYC suppression using PPAR-γ antagonist2023
- Author(s)
  Yukako Nakao-Ise, Takumi Narita, Shingo Miyamoto, Motoki Watanabe, Takuji Tanaka, Yoshihiro Sowa, Yosuke Iizumi, Mitsuharu Masuda, Gen Fujii, Yasuko Hirai, Toshimasa Nakao, Hideki Takakura, Michihiro Mutoh
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 73 Issue: 3 Pages: 191-197
- DOI
  10.3164/jcbn.23-28
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K10489
[Journal Article] コーヒー成分の大腸がん予防のメカニズムについて2023
- Author(s)
  渡邉　元樹
- Journal Title
  
  食と医療
  
  Volume: 27 Pages: 22-31
- Data Source
  KAKENHI-PROJECT-22K10489
[Journal Article] A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS52022
- Author(s)
  Watanabe Motoki、Boku Shogen、Kobayashi Kaito、Kurumida Yoichi、Sukeno Mamiko、Masuda Mitsuharu、Mizushima Katsura、Kato Chikage、Iizumi Yosuke、Hirota Kiichi、Naito Yuji、Mutoh Michihiro、Kameda Tomoshi、Sakai Toshiyuki
- Journal Title
  
  PNAS Nexus
  
  Volume: 1 Issue: 2
- DOI
  10.1093/pnasnexus/pgac059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10489, KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-19H01079
[Journal Article] Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol2022
- Author(s)
  Iizumi Yosuke, Sowa Yoshihiro, Goi Wakana, Aono Yuichi, Watanabe Motoki, Kurumida Yoichi, Kameda Tomoshi, Akaji Kenichi, Kitagawa Masatoshi, Sakai Toshiyuki.
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 564-564
- DOI
  10.1038/s42003-022-03522-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07378, KAKENHI-PROJECT-22K10489, KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-19H01079
[Journal Article] Citrus limon L.-Derived Nanovesicles Show an Inhibitory Effect on Cell Growth in p53-Inactivated Colorectal Cancer Cells via the Macropinocytosis Pathway2022
- Author(s)
  Takakura Hideki、Nakao Toshimasa、Narita Takumi、Horinaka Mano、Nakao-Ise Yukako、Yamamoto Tetsushi、Iizumi Yosuke、Watanabe Motoki、Sowa Yoshihiro、Oda Keisuke、Mori Nobuhiro、Sakai Toshiyuki、Mutoh Michihiro
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 6 Pages: 1352-1352
- DOI
  10.3390/biomedicines10061352
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10489, KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H03889
[Journal Article] Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells.2018
- Author(s)
  Iizuka-Ohashi M1,2, Watanabe M1, Sukeno M1, Morita M1, Hoang NTH3, Kuchimaru T, Kizaka-Kondoh S, Sowa Y1 Sakaguchi K, Taguchi T, Sakai T.
- Journal Title
  
  Oncotarget.
  
  Volume: 9 Issue: 28 Pages: 19597-19612
- DOI
  10.18632/oncotarget.24696
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10512, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-16K15378
[Journal Article] Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2.2018
- Author(s)
  Aono Y, Horinaka M, Iizumi Y, Watanabe M, Taniguchi T, Yasuda S, Sakai T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 505 Pages: 1203-1210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02529
[Presentation] 植物由来エクソソーム様ナノ小胞の新規大腸癌予防食品としての応用へ向けた検討2024
- Author(s)
  髙倉英樹, 小田啓祐, 中尾俊雅, 成田匠, 堀中真野, 中尾-伊勢由佳子, 山本哲志, 飯泉陽介, 渡邉元樹, 曽和義広, 酒井敏行, 武藤倫弘, 森信博
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] OH基を有する抗がん物質の標的タンパク質同定法の開発2023
- Author(s)
  飯泉陽介, 曽和義広, 青野裕一, 渡邉元樹, 酒井敏行
- Organizer
  第27回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS52023
- Author(s)
  Shogen Boku, Motoki Watanabe, Kaito Kobayashi, Yoichi Kurumida, Mamiko Sukeno, Mitsuharu Masuda, Katsura Mizushima, Chikage Kato, Yosuke Iizumi, Kiichi Hirota, Yuji Naito, Michihiro Mutoh, Tomoshi Kameda, Toshiyuki Sakai
- Organizer
  第20回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] OH基を有する天然物質の標的タンパク質同定法の開発と抗がんメカニズムの解明2023
- Author(s)
  飯泉陽介, 曽和義広, 後居和佳奈, 青野裕一, 渡邉元樹, 来見田遥一, 亀田倫史, 赤路健一, 北川雅敏, 酒井敏行
- Organizer
  第８２回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] OH基を有する化合物の標的タンパク質同定法の開発と抗がん作用の機序解明2023
- Author(s)
  飯泉陽介, 曽和義広, 後居和佳奈, 青野裕一, 渡邉元樹, 来見田遥一, 亀田倫史, 赤路健一, 北川雅敏, 酒井敏行
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] ケモプロテオミクスによるMEK阻害剤の細胞死誘導抵抗性機構の解明と新規標的分子RPS5の発見2023
- Author(s)
  渡邉元樹, 朴将源, 加藤千翔, 飯泉陽介, 酒井敏行
- Organizer
  第27回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] OH基を有する化合物全般に使える標的タンパク質同定法の開発2023
- Author(s)
  飯泉陽介, 曽和義広, 後居和佳奈, 青野裕一, 渡邉元樹, 来見田遥一, 亀田倫史, 赤路健一, 北川雅敏, 酒井敏行
- Organizer
  第２８回日本フードファクター学会学術集会
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] OH基が一つあれば、化合物の標的タンパク質を同定できる手法の開発2023
- Author(s)
  飯泉陽介, 曽和義広, 後居和佳奈, 青野裕一, 渡邉元樹, 来見田遥一, 亀田倫史, 赤路健一, 北川雅敏, 酒井敏行
- Organizer
  日本ケミカルバイオロジー学会第17回年会
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS52023
- Author(s)
  Shogen Boku, Motoki Watanabe, Tomoshi Kameda
- Organizer
  The 6th International Cancer Research Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] OH基を有する化合物の標的タンパク質同定法の開発と作用機序解明2023
- Author(s)
  飯泉陽介, 曽和義広, 後居和佳奈, 青野裕一, 渡邉元樹, 来見田遥一, 亀田倫史, 赤路健一, 北川雅敏, 酒井敏行
- Organizer
  第22回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] ポストゲノム時代のケモプロテオインフォマティクス創薬戦略2022
- Author(s)
  渡邉元樹, 朴将源, 亀田倫史
- Organizer
  がん予防学術大会2022
- Invited
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] 脾腫が腸ポリープ生成に与える影響（第二報）2022
- Author(s)
  成田匠, 中尾俊雅, 増田光治, 曽和義広, 渡邉元樹, 飯泉陽介, 宮本慎吾, 武藤倫弘
- Organizer
  がん予防学術大会2022
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] Prevention of intestinal polyps by Brassicaceae2022
- Author(s)
  NARITA Takumi, FUJII Gen, MASUDA Mitsuharu, SOWA Yoshihiro, MIYAMOTO Singo, WATANABE Motoki, IIZUMI Yosuke, MUTOH Michihiro
- Organizer
  第45回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] 植物由来エクソソーム様ナノ粒子による大腸がん予防効果の検討2022
- Author(s)
  高倉英樹, 小田啓祐, 中尾俊雅, 成田匠, 堀中真野, 中尾・伊勢由佳子, 山本哲志, 飯泉陽介, 渡邉元樹, 曽和義広, 酒井敏行, 武藤倫弘, 森信博
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] Rabdosianone I, a bitter diterpene from an oriental herb Isodon japonicus Hara -Identification of its direct targets in cancer cells and elucidation of anticancer mechanisms of action2022
- Author(s)
  Motoki Watanabe, Yasumasa Yamada
- Organizer
  8th International Conference on Food Chemistry & Technology (FCT-2022)
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] ポストゲノム時代のケモプロテオインフォマティクス創薬戦略－天然化合物から化学予防剤へ―2022
- Author(s)
  渡邉元樹, 朴将源, 亀田倫史
- Organizer
  第81回日本癌学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K10489
[Presentation] 新規スリンダクスルホン結合タンパク質VDACによる細胞周期制御のメカニズムの解析2019
- Author(s)
  青野裕一，堀中真野，飯泉陽介，渡邉元樹，谷口知行，安田周祐，酒井敏行
- Organizer
  第18回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-15H02529
[Presentation] スリンダク代謝体の大腸腺腫形成抑制作用における新規標的分子の探索と作用機序の解析2019
- Author(s)
  青野裕一，堀中真野，飯泉陽介，渡邉元樹，谷口知行，安田周祐，酒井敏行
- Organizer
  第89回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-15H02529
[Presentation] セサミノール結合タンパク質ANT2の発見がもたらすcyclin D1の多面的制御機構の解明2018
- Author(s)
  渡邉元樹
- Organizer
  第17回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-26670337
[Presentation] Combined effects of MEK inhibitors and statins on cancer cells2018
- Author(s)
  Iizuka-Ohashi Mahiro、Watanabe Motoki、Taguchi Tetsuya、Sakai Toshiyuki
- Organizer
  TAT2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15378
[Presentation] 新規セサミノール結合蛋白質ANT2によるcyclin D1の多面的制御機構の解明2018
- Author(s)
  渡邉元樹、飯泉陽介、曽和義広、酒井敏行
- Organizer
  第２２回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02529
[Presentation] セサミノール結合タンパク質ANT2の発見がもたらすcyclin D1の多面的制御機構の解明2018
- Author(s)
  渡邉元樹、飯泉陽介、助野真由美、曽和義広、酒井敏行
- Organizer
  第１７回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-15H02529
[Presentation] 新規セサミノール結合蛋白質ANT2によるcyclin D1の多面的制御機構の解明2018
- Author(s)
  渡邉元樹
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-26670337
[Presentation] セサミノール結合タンパク質ANT2の発見がもたらす新たな細胞周期調節機構の解明2018
- Author(s)
  渡邉元樹
- Organizer
  第88回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-26670337
[Presentation] メバロン酸経路の阻害はAkt経路の活性化を抑制しMEK阻害剤によるアポトーシスを惹起する2018
- Author(s)
  渡邉元樹、飯塚まひろ、曽和義広、酒井敏行
- Organizer
  がん予防学術大会2018
- Data Source
  KAKENHI-PROJECT-16K15378
[Presentation] セサミノール結合タンパク質ANT2の発見がもたらす新たな細胞周期調節機構の解明2018
- Author(s)
  渡邉元樹、飯泉陽介、助野真由美、曽和義広、酒井敏行
- Organizer
  第８８回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-15H02529
[Presentation] プロテオーム解析により新規に同定されたセサミノール結合蛋白質ANT2によるcyclin D1の多面的制御2017
- Author(s)
  渡邉元樹
- Organizer
  がん予防学術大会2017
- Data Source
  KAKENHI-PROJECT-26670337
[Presentation] The strategy of molecular-targeting cancer prevention (がんの分子標的予防戦略)2017
- Author(s)
  堀中真野, 飯泉陽介, 渡邉元樹, 増田光治, 曽和義広, 酒井敏行
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Invited
- Data Source
  KAKENHI-PROJECT-15H02529
[Presentation] プロテオーム解析により新規に同定されたセサミノール結合蛋白質ANT2はcyclin D1を多面的に制御する2017
- Author(s)
  渡邉元樹
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-26670337

1. SAKAI Toshiyuki (20186993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. 増田光治 (10305568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 友杉真野 (80512037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 曽和義広 (70315935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 飯泉陽介 (20533178)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. 石川秀樹 (30351795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 亀田倫史 (40415774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
8. HORINAKA Mano

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
9. 阪口晃一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 北川雅敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Watanabe Motoki 渡邉 元樹

渡邉 元樹 ワタナベ モトキ

Research Projects

Research Products

Co-Researchers

分子・細胞から集団レベルまでを包括したPFASの発がん性に対する分野横断的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Chemoproteomics and molecular dynamics simulation-based drug discovery platforms for chemopreventionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Reserch into the mechanism how coffee prevents colorectal cancer using chemical biology approachPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of chemoprevention for familial breast cancer focusing on the cancer metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Application of molecular-targeting cancer prevention to human intervention study.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The investigation for the critical cause of ERalpha-positive breast cancer and the establishment of its chemoprevention using chemical biologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Induction of <i>MYCN</i>-amplified neuro­blastoma differentiation through NMYC suppression using PPAR-γ antagonist2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] コーヒー成分の大腸がん予防のメカニズムについて2023

Author(s)

Journal Title

Data Source

[Journal Article] A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS52022

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[Journal Article] Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol2022

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[Journal Article] Citrus limon L.-Derived Nanovesicles Show an Inhibitory Effect on Cell Growth in p53-Inactivated Colorectal Cancer Cells via the Macropinocytosis Pathway2022

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[Journal Article] Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells.2018

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[Journal Article] Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2.2018

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[Presentation] 植物由来エクソソーム様ナノ小胞の新規大腸癌予防食品としての応用へ向けた検討2024

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Watanabe Motoki 渡邉元樹

渡邉元樹ワタナベモトキ

[Journal Article] Induction of <i>MYCN</i>-amplified neuroblastoma differentiation through NMYC suppression using PPAR-γ antagonist2023

[Presentation] ポストゲノム時代のケモプロテオインフォマティクス創薬戦略－天然化合物から化学予防剤へ―2022