IMAI JIN 今井仁

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IMAI Jin 今井仁

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Researcher Number	40725363
Other IDs
Affiliation (Current)	2025: 東海大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2023 – 2025: 東海大学, 医学部, 講師 2019 – 2022: 東海大学, 医学部, 助教 2016: 東海大学, 医学部, 助教 2015: 東海大学, 医学部附属病院, 臨床助手
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator 炎症性腸疾患 / クローン病 / 腸内細菌 / IgA / 腸管免疫 / 口腔内細菌 / 線維化 / YB-1 / TGF-β / 腸管線維化 … More Except Principal Investigator … More 大腸がん / ピロリ菌 / 短鎖脂肪酸 / オートファジー / 腸内細菌 / 免疫応答 / 病原性共生菌 Less

Mechanism of gastrointestinal cancer development regulated by gut commensal bacteria-induced specific host cells
- Principal Investigator
  
  津川仁
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tokai University
Analysis of Notch-dependent specific immune response against pathobiont and application to mucosal vaccine
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tokai University
クローン病の腸管内病原性共生菌に特異的なIgAを用いた新しい診断と治療技術の開発Principal Investigator
- Principal Investigator
  
  今井仁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokai University
Identification of inflammation-inducing bacteria from oral microbiota in inflammatory bowel diseasePrincipal Investigator
- Principal Investigator
  
  IMAI Jin
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokai University
Analysis of collagen producing cell and new therapeutic target of TGF-b signal in colorectal fibrosisPrincipal Investigator
- Principal Investigator
  
  IMAI Jin
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokai University

All 2024 2023 2022 2021 2020 2019 2016 2015

All Journal Article Presentation Book Patent

[Book] 医学のあゆみ2020
- Author(s)
  今井仁, 穂積勝人, 鈴木秀和
- Total Pages
  5
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-19K17413
[Journal Article] Cyclic-di-AMP confers an invasive phenotype on Escherichia coli through elongation of flagellin filaments2024
- Author(s)
  Tanaka Rika、Imai Jin、Sugiyama Eiji、Tsubaki Shogo、Hozumi Katsuto、Tsugawa Hitoshi
- Journal Title
  
  Gut Pathogens
  
  Volume: 16 Issue: 1 Pages: 6-6
- DOI
  10.1186/s13099-024-00600-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06585, KAKENHI-PROJECT-22K08042, KAKENHI-PROJECT-23H00554
[Journal Article] Prediction and Validation of Metabolic Dysfunction-Associated Fatty Liver Disease Using Insulin Resistance-Related Indices in the Japanese Population2023
- Author(s)
  Moriyama Kengo、Inoue Nagamu、Imai Jin、Masuda Yumi、Yamada Chizumi、Kishimoto Noriaki、Takashimizu Shinji、Kubo Akira、Nishizaki Yasuhiro
- Journal Title
  
  Metabolic Syndrome and Related Disorders
  
  Volume: 21 Issue: 9 Pages: 489-496
- DOI
  10.1089/met.2023.0116
- Data Source
  KAKENHI-PROJECT-22K08042
[Journal Article] The role of inflammation in homocysteine-related muscle weakness in relatively healthy Japanese men and women2023
- Author(s)
  Yamada Chizumi、Okuno Chiori、Sakai Yurina、Imai Jin、Nagamu Inoue、Moriyama Kengo、Kishimoto Noriaki、Nishizaki Yasuhiro
- Journal Title
  
  Health Evaluation and Promotion
  
  Volume: 50 Issue: 4 Pages: 420-426
- DOI
  10.7143/jhep.2023-11
- ISSN
  1347-0086, 1884-4103
- Language
  English
- Data Source
  KAKENHI-PROJECT-22K08042
[Journal Article] A case of breast cancer with extensive colon metastasis.2023
- Author(s)
  Jin Imai, Toru Hanamura, Aya Kawanishi, Takashi Ueda, Yusuke Mishima, et al.
- Journal Title
  
  DEN open
  
  Volume: 3(1) Issue: 1
- DOI
  10.1002/deo2.189
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08042, KAKENHI-PROJECT-20K16972, KAKENHI-PROJECT-20H03667
[Journal Article] Adherent-invasive E. coli - induced specific IgA limits pathobiont localization to the epithelial niche in the gut.2023
- Author(s)
  Rika Tanaka, Jin Imai, Hitoshi Tsugawa, Karl Bil Eap, Masaki Yazawa, Motoki Kaneko, Masashi Ohno, Kohei Sugihara, Sho Kitamoto, Hiroko Nagao-Kitamoto, Nicolas Barnich, Masashi Matsushima, Takayoshi Suzuki, Tatehiro Kagawa, Yasuhiro Nishizaki, Hidekazu Suzuki, Nobuhiko Kamada, Katsuto Hozumi
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 14 Pages: 1031997-1031997
- DOI
  10.3389/fmicb.2023.1031997
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08042, KAKENHI-PROJECT-20K16972, KAKENHI-PROJECT-22K06585
[Journal Article] Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction.2022
- Author(s)
  Kohei Sugihara, Sho Kitamoto, Prakaimuk Saraithong, Hiroko Nagao-Kitamoto, Matthew Hoostal, Caroline McCarthy, Alexandra Rosevelt, Chithra K Muraleedharan, Merritt G Gillilland 3rd, Jin Imai,et al.
- Journal Title
  
  Cell reports
  
  Volume: 40(3) Issue: 3 Pages: 111093-111093
- DOI
  10.1016/j.celrep.2022.111093
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08042
[Journal Article] The pathogenic oral-gut-liver axis: new understandings and clinical implications2021
- Author(s)
  Imai J, Kitamoto S, Kamada N
- Journal Title
  
  Expert Rev Clin Immunol
  
  Volume: 17(7) Issue: 7 Pages: 727-736
- DOI
  10.1080/1744666x.2021.1935877
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17413
[Journal Article] Notch signaling supports the appearance of follicular helper T cells in the Peyer's patches concomitantly with the reduction of regulatory T cells2021
- Author(s)
  Yazawa M, Hosokawa H, Koizumi M, Hirano KI, Imai J, Hozumi K.
- Journal Title
  
  Int Immunol
  
  Volume: 33(9) Issue: 9 Pages: 469-478
- DOI
  10.1093/intimm/dxab032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20K07330
[Journal Article] A potential pathogenic association between periodontal disease and Crohn's disease2021
- Author(s)
  Imai J, Ichikawa H, Kitamoto S, Golob JL, Kaneko M, Nagata J, Takahashi M, Gillilland MG 3rd, Tanaka R, Nagao-Kitamoto H, Hayashi A, Sugihara K, Bishu S, Tsuda S, Ito H, Kojima S, Karakida K, Matsushima M, Suzuki T, Hozumi K, Watanabe N, Giannobile WV, Shirai T, Suzuki H, Kamada N
- Journal Title
  
  JCI insight
  
  Volume: 6(23) Issue: 23
- DOI
  10.1172/jci.insight.148543
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-20H03667, KAKENHI-PROJECT-20K16972
[Journal Article] Primary Sclerosing Cholangitis Complicated with Aphthoid Colitis Difficult to Diagnose from IgG4-Related Sclerosing Cholangitis2021
- Author(s)
  Imai J, Ichikawa H, Kaneko M, Ito H, Takashimizu S, Shirai T, Tajiri T, Watanabe N, Suzuki H
- Journal Title
  
  Case Rep Gastroenterol
  
  Volume: 16(1) Issue: 1 Pages: 23-28
- DOI
  10.1159/000521538
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-20H03667, KAKENHI-PROJECT-22K08042, KAKENHI-PROJECT-20K16972
[Journal Article] Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium2021
- Author(s)
  Hirano KI, Hosokawa H, Yahata T, Ando K, Tanaka M, Imai J, Yazawa M, Ohtsuka M, Negishi N, Habu S, Sato T, Hozumi K.
- Journal Title
  
  Front Immunol
  
  Volume: 13 Pages: 852427-852427
- DOI
  10.3389/fimmu.2022.852427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20K07330, KAKENHI-PROJECT-22K08042, KAKENHI-PROJECT-23K21386
[Journal Article] The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis2020
- Author(s)
  Sho Kitamoto, Hiroko Nagao-Kitamoto, Yizu Jiao, Merritt G Gillilland, Atsushi Hayashi, Jin Imai, Kohei Sugihara, Mao Miyoshi, Jennifer C Brazil, Peter Kuffa, Brett D Hill, Syed M Rizvi, Fei Wen, Shrinivas Bishu, Naohiro Inohara, Kathryn A Eaton, Asma Nusrat, Yu L Lei, William V Giannobile, Nobuhiko Kamada
- Journal Title
  
  Cell
  
  Volume: 182(2) Issue: 2 Pages: 447-462
- DOI
  10.1016/j.cell.2020.05.048
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17413
[Journal Article] Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice2019
- Author(s)
  Imai J, Yahata T, Ichikawa H, Ibrahim AA, Yazawa M, Sumiyoshi H, Inagaki Y, Matsushima M, Suzuki T, Mine T, Ando K, Miyata T, Hozumi K.
- Journal Title
  
  Intestinal Research
  
  Volume: 18 Issue: 2 Pages: 219-228
- DOI
  10.5217/ir.2019.00037
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08603, KAKENHI-PROJECT-18K14702, KAKENHI-PROJECT-19K22627, KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-17H04166
[Journal Article] Flagellin-mediated activation of IL-33-ST2 signaling by a pathobiont promotes intestinal fibrosis.2019
- Author(s)
  Imai J, Kitamoto S, Sugihara K, Nagao-Kitamoto H, Hayashi A, Morhardt TL, Kuffa P, Higgins PDR, Barnich N, Kamada N
- Journal Title
  
  Mucosal Immunology
  
  Volume: 12 Issue: 3 Pages: 632-643
- DOI
  10.1038/s41385-019-0138-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17413
[Journal Article] Intestinal Fibrosis and Liver Fibrosis: Consequences of Chronic Inflammation or Independent Pathophysiology?2016
- Author(s)
  Rieder F, Bettenworth D, Imai J, Inagaki Y.
- Journal Title
  
  Inflamm Intest Dis
  
  Volume: 印刷中 Issue: 1 Pages: 41-49
- DOI
  10.1159/000445135
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19353, KAKENHI-PROJECT-25293179, KAKENHI-PROJECT-15K15299
[Journal Article] Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis.2015
- Author(s)
  Imai J, Hozumi K, Sumiyoshi H, Yazawa M, Hirano K, Abe J, Higashi K, Inagaki Y, Mine T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 468(4) Pages: 554-560
- DOI
  10.1155/2016/2964581
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19353
[Patent] 接着性侵入性大腸菌に対するモノクローナルIgA抗体とその使用2023
- Inventor(s)
  今井　仁, 穂積　勝人
- Industrial Property Rights Holder
  学校法人東海大学
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K08042
[Presentation] クローン病に関連する病原性共生細菌に対する特異的IgA抗体の機能解析とその臨床応用2023
- Author(s)
  今井　仁, 穂積　勝人
- Organizer
  第144回日本薬学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08042
[Presentation] 炎症性腸疾患における病原性共生菌へのIgA応答と臨床応用2023
- Author(s)
  今井　仁,　穂積　勝人
- Organizer
  第56回日本無菌生物ノートバイオロジー学会
- Data Source
  KAKENHI-PROJECT-22K08042
[Presentation] 接着性侵入性大腸菌(AIEC)に対するIgA応答の解明2023
- Author(s)
  今井　仁,田中里佳, 津川仁, 西崎　泰弘, 鈴木　秀和, 穂積　勝人
- Organizer
  第50回日本潰瘍学会
- Data Source
  KAKENHI-PROJECT-22K08042
[Presentation] クローン病の腸管線維化に影響を与える病原性共生菌の同定とそのメカニズム2023
- Author(s)
  今井　仁, 鈴木　秀和，西崎　泰弘, 鎌田　信彦
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-22K08042
[Presentation] 歯周病合併クローン病における口腔内・腸内細菌叢解析と臨床経過2020
- Author(s)
  今井仁, 鎌田信彦, 北本祥, 市川仁志, 高橋美穂, 白井孝之, 穂積勝人, 鈴木秀和
- Organizer
  GI WEEK 2021
- Data Source
  KAKENHI-PROJECT-19K17413
[Presentation] クローン病における接着性侵入性大腸菌（AIEC）による腸管線維化誘導の検討2020
- Author(s)
  今井仁, 鈴木秀和
- Organizer
  第39回サイトプロテクション研究会
- Data Source
  KAKENHI-PROJECT-19K17413
[Presentation] 接着性侵入性大腸菌(AIEC)はIL-33/ST2シグナルを介し腸管線維化を誘導する2019
- Author(s)
  今井仁, 鈴木孝良, 鎌田信彦
- Organizer
  第27回日本消化器関連学会週間 JDDW
- Data Source
  KAKENHI-PROJECT-19K17413
[Presentation] 炎症性腸疾患と口腔内環境との関連性について2019
- Author(s)
  市川仁志, 今井仁, 金子元基, 津田真吾, 永田順子, 白井孝之, 高橋美穂, 唐木田一成, 高山哲朗, 伊藤裕幸, 小嶋清一郎, 坂本春生, 渡辺勲史
- Organizer
  第27回日本消化器関連学会週間 JDDW
- Data Source
  KAKENHI-PROJECT-19K17413
[Presentation] Adherent-invasive Escherichia coli colonization promotes intestinal fibrosis via activation of IL-33-ST2 signaling2019
- Author(s)
  Jin Imai, Sho Kitamoto, Hiroko Nagao-Kitamoto, Atsushi Hayashi, Kohei Sugihara, Tina L. Morhardt, Peter Kuffa, Peter D. R. Higgins, Nicolas Barnich, Nobuhiko Kamada
- Organizer
  DDW (Digestive Disease Week) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17413
[Presentation] Anti-fibrotic effects of a novel small compound that promotes the nuclear translocation of YB-1 in a mouse model of colorectal fibrosis.2016
- Author(s)
  Imai J, Hozumi K, Inagaki Y, Mine T.
- Organizer
  European Crohn's and Colitis Organisation 2016
- Place of Presentation
  ＲＡＩ Amsterdam (Netherlands)
- Year and Date
  2016-03-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19353
[Presentation] YB-1の核内移行を促進させる小化合物を用いたクローン病腸管線維化モデルに対する抗線維化治療の検討2016
- Author(s)
  今井　仁、峯　徹哉、稲垣　豊、穂積　勝人
- Organizer
  第102回に本消化器病学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K19353

1. 津川仁 (30468483)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. HOZUMI Katsuto (30246079)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. INAGAKI Yutaka (80193548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. MINE Tetsuya (20157572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 杉山栄二 (90806332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 住吉秀明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IMAI JIN 今井 仁

IMAI Jin 今井 仁

Research Projects

Research Products

Co-Researchers

Mechanism of gastrointestinal cancer development regulated by gut commensal bacteria-induced specific host cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of Notch-dependent specific immune response against pathobiont and application to mucosal vaccine

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

クローン病の腸管内病原性共生菌に特異的なIgAを用いた新しい診断と治療技術の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of inflammation-inducing bacteria from oral microbiota in inflammatory bowel diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of collagen producing cell and new therapeutic target of TGF-b signal in colorectal fibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 医学のあゆみ2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Cyclic-di-AMP confers an invasive phenotype on Escherichia coli through elongation of flagellin filaments2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prediction and Validation of Metabolic Dysfunction-Associated Fatty Liver Disease Using Insulin Resistance-Related Indices in the Japanese Population2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of inflammation in homocysteine-related muscle weakness in relatively healthy Japanese men and women2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] A case of breast cancer with extensive colon metastasis.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adherent-invasive E. coli - induced specific IgA limits pathobiont localization to the epithelial niche in the gut.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The pathogenic oral-gut-liver axis: new understandings and clinical implications2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Notch signaling supports the appearance of follicular helper T cells in the Peyer's patches concomitantly with the reduction of regulatory T cells2021

Author(s)

Journal Title

IMAI JIN 今井仁

IMAI Jin 今井仁