TAKAI YOSHIKI 高井良樹

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Takai Yoshiki 高井良樹

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Researcher Number	40725743
Other IDs	https://orcid.org/0000-0003-1071-2186
Affiliation (Current)	2025: 東北大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 東北大学, 大学病院, 助教 2015 – 2019: 東北大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator General pharmacology
Keywords	Principal Investigator 炎症性脱髄疾患 / 多発性硬化症 / 視神経脊髄炎 / 腫瘍様炎症性脱髄疾患 / 虚血性組織障害 / MOG / T細胞 / AQP4 / MOGAD / ADEM … More / 補体 / 中枢性炎症性脱髄疾患 / MOG抗体関連疾患 / Balo病 / HMGB-1 / DAMPs / NMO / Balo / TDD / 虚血 / Tenascin-C / HIF-1 / 脳虚血 / Tenascin / TRL / 自然免疫 / 二次性脱髄機序の解明 / NMOモデルの確立 / 炎症性サイトカイン / アクアポリン４ / 脱髄 / アストロサイト … More Except Principal Investigator アストロサイト / 抗体製剤 / 免疫学 / 脳神経疾患 / 動物 / 薬理学 / 医療・福祉 / 自己免疫疾患 / 内在化／エンドサイトーシス / 抗体医薬 / 動物モデル / モノクローナル抗体 / 視神経脊髄炎 / アクアポリン４ Less

腫瘍様炎症性脱髄病変の分子病理学的分類と新規病態の解明Principal Investigator
- Principal Investigator
  
  高井良樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Tohoku University
Molecular immunopathological analysis of clinical phenotype and severity of MOG antibody-associated diseasesPrincipal Investigator
- Principal Investigator
  
  TAKAI YOSHIKI
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Tohoku University
Involvement of ischemic tissue injury in inflammatory demyelinating disease and its therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  Takai Yoshiki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Development of new therapy for neuromyelitis optica using its animal models and anti-AQP4 antibodies.
- Principal Investigator
  
  Abe Yoichiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Keio University
Elucidation of demyelination mechanism caused by astrocyte injuryPrincipal Investigator
- Principal Investigator
  
  Takai Yoshiki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Diagnostic implications of MOG-IgG detection in sera and cerebrospinal fluids2023
- Author(s)
  Matsumoto Yuki、Kaneko Kimihiko、Takahashi Toshiyuki、Takai Yoshiki、Namatame Chihiro、Kuroda Hiroshi、Misu Tatsuro、Fujihara Kazuo、Aoki Masashi
- Journal Title
  
  Brain
  
  Volume: － Issue: 9 Pages: 3938-3948
- DOI
  10.1093/brain/awad122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07453, KAKENHI-PROJECT-23K06959
[Journal Article] Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease With False-Positive Results in SARS-CoV-2 Antigen Tests: A Case Report2022
- Author(s)
  Yamamoto Naoki、Ikenouchi Hajime、Takai Yoshiki、Endo Kaoru、Aoki Masashi
- Journal Title
  
  Cureus
  
  Volume: 14
- DOI
  10.7759/cureus.31514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07453
[Journal Article] A tumefactive anti-MOG antibody associated disorder heralding central nervous system B-cell lymphoma: Case report on diagnostic challenge2022
- Author(s)
  Uzura Yasunori、Takeuchi Hayato、Ashida Shinji、Fujii Chihiro、Shishido-Hara Yukiko、Inaba Tohru、Takai Yoshiki、Akazawa Kentaro、Mizuno Toshiki、Hashimoto Naoya
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 365 Pages: 577823-577823
- DOI
  10.1016/j.jneuroim.2022.577823
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07397, KAKENHI-PROJECT-19K08233, KAKENHI-PROJECT-21K07453
[Journal Article] Staging of astrocytopathy and complement activation in neuromyelitis optica spectrum disorders2021
- Author(s)
  nji Okita, Shunichi Sasou, Mika Watanabe, Chihiro Namatame, Yuki MatYoshiki Takai, Tatsuro Misu, Hiroyoshi Suzuki, Toshiyuki Takahashi, Hiromi Okada, Shinya Tanaka, Kesumoto, Hirohiko Ono, Kimihiko Kaneko, Shuhei Nishiyama, Hiroshi Kuroda, Ichiro Nakashima, Hans Lassmann, Kazuo Fujihara, Yasuto Itoyama, Masashi Aoki
- Journal Title
  
  Brain
  
  Volume: 144(8) Issue: 8 Pages: 2401-2415
- DOI
  10.1093/brain/awab102
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07453
[Journal Article] Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study2020
- Author(s)
  Takai Y, Misu M, Kaneko K, Chihara N, Narikawa K, Tsuchida S, Nishida H, Komori T, Seki M, Komatsu T, Nakamagoe K, Ikeda T, Yoshida M, Takahashi T, Ono H, Nishiyama S, Kuroda H, Nakashima I, Suzuki H, Bradl M, Lassmann H, Fujihara K, Aoki M
- Journal Title
  
  Brain
  
  Volume: In press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16108
[Journal Article] Hypoxia-like tissue injury and glial response contribute to Balo concentric lesion development.2016
- Author(s)
  Takai Y, Misu T, Nishiyama S, Ono H, Kuroda H, Nakashima I, Saito R, Kanamori M, Sonoda Y, Kumabe T, Mugikura S, Watanabe M, Aoki M, Fujihara K.
- Journal Title
  
  Neurology.
  
  Volume: Nov 8;87(19) Pages: 2000-2005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19473
[Journal Article] The binding property of a monoclonal antibody against the extracellular domains of aquaporin-4 directs aquaporin-4 toward endocytosis.2016
- Author(s)
  Huang P*, Takai Y*, Kusano AO, Ramadhanti J, Iwanari H, Miyauchi T, Sakihama T, YanHan J, Aoki M, Hamakubo T, Fujihara K, Yasui M, Abe Y. *authors with same contribution.
- Journal Title
  
  Biochemistry and Biophysics Reports.
  
  Volume: 7 Pages: 77-83
- DOI
  10.1016/j.bbrep.2016.05.017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19473, KAKENHI-PROJECT-15K14513
[Journal Article] Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody.2015
- Author(s)
  Kurosawa K, Misu T, Takai Y, Sato DK, Takahashi T, Abe Y, Iwanari H, Ogawa R, Nakashima I, Fujihara K, Hamakubo T, Yasui M, Aoki M.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 4 Issue: 1 Pages: 783-783
- DOI
  10.1186/s40478-015-0259-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09332, KAKENHI-PROJECT-15K19473, KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-26293205
[Journal Article] High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with the neuromyelitis optica autoantibody, NMO-IgG.2015
- Author(s)
  Miyazaki-Komine K, Takai Y, Huang P, Kusano-Arai O, Iwanari H, Misu T, Koda K, Mitomo K, Sakihama T, Toyama Y, Fujihara K, Hamakubo T, Yasui M, Abe Y.
- Journal Title
  
  Br J Pharmacol
  
  Volume: 173 Issue: 1 Pages: 103-103
- DOI
  10.1111/bph.13340
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09332, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-26293205, KAKENHI-PROJECT-15K19473
[Presentation] シンポジウム２　MOG関連疾患とAQP4抗体陽性視神経脊髄炎の相違2022
- Author(s)
  高井良樹
- Organizer
  第34回神経免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07453
[Presentation] シンポジウム19　MOGADの病理と病態2022
- Author(s)
  高井良樹
- Organizer
  第40回神経治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07453
[Presentation] Perivascular macrophage infiltration and the myelin phagocytos is in MOG antibody-associated diseases2021
- Author(s)
  Y Takai, T Misu, C Namatame, Y Mastumoto, H Ono, K Kaneko, T Takahashi, K Fujihara, M Aoki
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07453
[Presentation] Cutting-edge advances in NMOSD and MOG-related disorders2021
- Author(s)
  Y Takai
- Organizer
  第62回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07453
[Presentation] Pathophysiology of MOGAD2021
- Author(s)
  Y Takai, T Misu, K Fujihara, Masashi Aoki
- Organizer
  29th Annual Meeting of the European Charcot Foundation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07453
[Presentation] Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study2019
- Author(s)
  Y Takai,T Misu, K Kaneko, N Chihara, K Narikawa, S Tsuchida, H Nishida, T Komori, M Seki, T Komatsu T, K Nakamagoe, T Ikeda, M Yoshida, T Takahashi, H Ono, S Nishiyama, H Kuroda, I Nakashima, H Suzuki, M Bradl, H Lassmann, K Fujihara, M Aoki.
- Organizer
  第60回日本神経学会学術大会（大阪）
- Data Source
  KAKENHI-PROJECT-17K16108
[Presentation] The Expression of IL-6 in The Central Nervous Tissue of Neuromyelitis Optica Spectrum Disorders2019
- Author(s)
  Y Takai, T Misu, C Namatame, Y Mastumoto, H Ono, K Kaneko, T Takahashi, S Nishiyama, H Kuroda, M Aoki, K Fujihara
- Organizer
  12th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (Singapore)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16108
[Presentation] 視神経脊髄炎中枢組織障害に対するIL-6の影響に関する病理学的検討2019
- Author(s)
  高井良樹, 三須建郎, 松本勇貴, 生田目千尋, 小野紘彦, 西山修平, 黒田宙, 藤原一男, 青木正志
- Organizer
  第31回日本神経免疫学会学術集会（千葉）
- Data Source
  KAKENHI-PROJECT-17K16108
[Presentation] Perivenous inflammatory demyelination with MOG-dominant myelin loss is a characteristic feature of MOG antibody-associated disease.2019
- Author(s)
  Y Takai,T Misu, K Kaneko, N Chihara, K Narikawa, S Tsuchida, H Nishida, T Komori, M Seki, T Komatsu T, K Nakamagoe, T Ikeda, M Yoshida, T Takahashi, H Ono, S Nishiyama, H Kuroda, I Nakashima, H Suzuki, M Bradl, H Lassmann, K Fujihara, M Aoki.
- Organizer
  35th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (Stockholm, Sweden)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16108
[Presentation] Perivenous inflammatory demyelination is the prominent pathology in myelin oligodendrocyte glycoprotein antibody-associated disease.2018
- Author(s)
  Takai Y, Misu T, Kaneko K, Chihara N, Narikawa K, Tsuchida S, Nishida H, Takahashi T, Aoki M, Fujihara K
- Organizer
  19th International Congress of Neuropathology (Tokyo, Japan)
- Data Source
  KAKENHI-PROJECT-17K16108
[Presentation] Perivenous inflammatory demyelination with myelin oligodendrocyte glycoprotein (MOG)-dominant myelin loss and CD4-dominant T cell infiltration is prominent in MOG antibody-associated disease.2018
- Author(s)
  Takai Y, Misu T, Kaneko K, Chihara N, Narikawa K, Tsuchida S, Nishida H, Takahashi T, Aoki M, Fujihara K
- Organizer
  11th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (Sydney, Australia)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16108
[Presentation] Perivenous inflammatory demyelination with CD4-dominat T cell infiltration is prominent in myelin oligodendrocyte glycoprotein antibody-associated disease.2018
- Author(s)
  Takai Y, Misu T, Kaneko K, Chihara N, Narikawa K, Tsuchida S, Nishida H, Takahashi T, Aoki M, Fujihara K
- Organizer
  34th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (Berlin, Germany)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16108
[Presentation] The staging of astrocytopathy in neuromyelitis optica spectrum disorders with aquaporin 4-IgG2017
- Author(s)
  Y. Takai, T. Misu, S. Nishiyama, H. Kuroda, R. Ogawa, K. Kaneko, T. Takahashi, I. Nakashima, Suzuki H, K. Fujihara, M. Aoki
- Organizer
  33rd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (London, United Kingdom)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16108
[Presentation] Balo病における同心円状脱髄病巣形成に対する虚血性組織障害とグリア細胞の関与2016
- Author(s)
  高井良樹、三須建郎、西山修平、黒田宙、中島一郎、渡辺　みか、齋藤竜太、金森政之、藤原一男、青木正志
- Organizer
  第28回日本神経免疫学会学術集会
- Place of Presentation
  長崎（長崎ブリックホール）
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15K19473
[Presentation] Temporal changes of pathological features in NMO Spectrum Disorders with aquaporin4 antibody.2016
- Author(s)
  Takai Y, Misu T, Nakashima I, Kuroda H, Takahashi T, Nishiyama S, Kaneko K, Akaishi T, Ogawa K, Fujihara K, Aoki M.
- Organizer
  32nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis
- Place of Presentation
  London, United Kingdom
- Year and Date
  2016-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19473
[Presentation] Chronological change is the main cause of histopathological diversity in neuromyelitis optica with anti-AQP4 antibody.2016
- Author(s)
  Takai Y, Misu T, Nakashima I, Kuroda H, Takahashi T, Nishiyama S, Kaneko K, Akaishi T, Ogawa K, Fujihara K, Aoki M.
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸（神戸コンベンションセンター）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K19473
[Presentation] Hypoxia-like tissue injury and glial response contribute to the development of Balo’s concentric demyelination2016
- Author(s)
  Takai Y, Misu T, Nishiyama S, Ono H, Kuroda H, Nakashima I, Saito R, Kanamori M, Mugikura S, Watanabe M, Aoki M, Fujihara K.
- Organizer
  9th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2016-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19473
[Presentation] Astrocyte injury and secondary demyelination in intracranial injection mouse model of NMO.2015
- Author(s)
  高井　良樹、阿部　陽一郎、三須　建郎、ジュリア　ラマダンティ、黒沢　和大、高橋　利幸、黒田　宙、中島　一郎、西山　修平、佐藤　ダグラス、安井　正人、藤原　一男、青木　正志
- Organizer
  第56回神経学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K19473
[Presentation] Astrocyte injury and secondary demyelination induced by intracerebral injection of AQP4-IgG and complement in mouse brain.2015
- Author(s)
  Yoshiki Takai, Yoichiro Abe, Tasturo Misu, Kazuhiro Kurosawa, Toshiyuki Takahashi, Hiroshi Kuroda, Ichiro Nakashima, Shuhei Nishiyama, Masato Yasui, Masashi Aoki, Kazuo Fujihara
- Organizer
  31st Congress of the european committee for treatment and research in multiplesclerosis
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-10-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19473
[Presentation] Astrocyte injury and secondary demyelination induced by intracerebral injection of AQP4-IgG and complement in mouse brain.2015
- Author(s)
  Yoshiki Takai, Yoichiro Abe, Tasturo Misu, Kazuhiro Kurosawa, Toshiyuki Takahashi, Hiroshi Kuroda, Ichiro Nakashima, Shuhei Nishiyama, Masato Yasui, Masashi Aoki, Kazuo Fujihara
- Organizer
  8th Congress of the Pan-Asian committee for research and treatment of multiple sclerosis
- Place of Presentation
  ソウル（韓国）
- Year and Date
  2015-11-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19473
[Presentation] NMOモデルマウスにおけるアストロサイト障害に伴う二次性脱髄機序の解明2015
- Author(s)
  高井良樹、三須建郎、黒沢和大、高橋利幸、中島一郎、黒田宙、西山修平、藤原一男、青木正志
- Organizer
  第27回日本神経免疫学会学術集会
- Place of Presentation
  岐阜
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-15K19473

1. Abe Yoichiro (10317331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. HARA Yukiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 青木正志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 三須建郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

TAKAI YOSHIKI 高井 良樹

Takai Yoshiki 高井 良樹

Research Projects

Research Products

Co-Researchers

腫瘍様炎症性脱髄病変の分子病理学的分類と新規病態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular immunopathological analysis of clinical phenotype and severity of MOG antibody-associated diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Involvement of ischemic tissue injury in inflammatory demyelinating disease and its therapeutic applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new therapy for neuromyelitis optica using its animal models and anti-AQP4 antibodies.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of demyelination mechanism caused by astrocyte injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Diagnostic implications of MOG-IgG detection in sera and cerebrospinal fluids2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease With False-Positive Results in SARS-CoV-2 Antigen Tests: A Case Report2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A tumefactive anti-MOG antibody associated disorder heralding central nervous system B-cell lymphoma: Case report on diagnostic challenge2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Staging of astrocytopathy and complement activation in neuromyelitis optica spectrum disorders2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study2020

Author(s)

Journal Title

Data Source

[Journal Article] Hypoxia-like tissue injury and glial response contribute to Balo concentric lesion development.2016

Author(s)

Journal Title

Data Source

[Journal Article] The binding property of a monoclonal antibody against the extracellular domains of aquaporin-4 directs aquaporin-4 toward endocytosis.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with the neuromyelitis optica autoantibody, NMO-IgG.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] シンポジウム２ MOG関連疾患とAQP4抗体陽性視神経脊髄炎の相違2022

Author(s)

TAKAI YOSHIKI 高井良樹

Takai Yoshiki 高井良樹

[Presentation] シンポジウム２　MOG関連疾患とAQP4抗体陽性視神経脊髄炎の相違2022

[Presentation] シンポジウム19　MOGADの病理と病態2022