SASAKI Tomoyuki 佐々木知幸

Researcher Number	40739124
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 山梨大学, 大学院総合研究部, 准教授 2017 – 2019: 山梨大学, 大学院総合研究部, 助教 2015 – 2016: 山梨大学, 総合研究部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator 血小板 / CLEC-2 / SARS-CoV-2 / 血栓症 / SARS ~CoV-2 / COVID-19 / 抗体医薬 / NETs / 好中球 / 敗血症 / ロドサイチン … More Except Principal Investigator … More 血小板 / CLEC-2 / 発生 / リンパ節 / リンパ管 / 異所性リンパ組織 / リンパ節発生 / ポドプラニン / 骨髄微小環境 / iPS細胞 / 造血微小環境 / 巨核球 Less

SARS-CoV-2による血小板血栓の形成メカニズムの解析Principal Investigator
- Principal Investigator
  
  佐々木知幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
iPS細胞由来巨核球が産生する血小板を活用したヒトCLEC-2の機能解析
- Principal Investigator
  
  大石沙織
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
Development of antibody drugs targeting platelet activating receptor CLEC-2 and elucidation of the pharmacological actionsPrincipal Investigator
- Principal Investigator
  
  Sasaki Tomoyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
A role of platelets in lymphoid tissue development: platelets as a cargo of bioactive substances
- Principal Investigator
  
  Suzuki-INoue Katsue
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
Development zeno-free/self-feeder culture system for an efficient iPSC derived platelet production
- Principal Investigator
  
  Tamura Shogo
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Nagoya University
Elucidation of the relationship between the platelet receptor CLEC-2 and the pathophysiology of sepsis and its application as a new therapeutic targetPrincipal Investigator
- Principal Investigator
  
  SASAKI Tomoyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Development of molecular-targeted therapeutic agent targeting novel platelet activation receptor CLEC-2Principal Investigator
- Principal Investigator
  
  SASAKI Tomoyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] Cancer-associated fibroblasts promote venous thrombosis through podoplanin/CLEC-2 interaction in podoplanin-negative lung cancer mouse model2023
- Author(s)
  Shirai Toshiaki、Tsukiji Nagaharu、Sasaki Tomoyuki、Oishi Saori、Yokomori Ryohei、Takano Katsuhiro、Suzuki-Inoue Katsue
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 21 Issue: 11 Pages: 3153-3165
- DOI
  10.1016/j.jtha.2023.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08500, KAKENHI-PROJECT-23K07831
[Journal Article] C-type lectin-like receptor-2 (CLEC-2) is a key regulator of kappa-carrageenan-induced tail thrombosis model in mice2023
- Author(s)
  Yokomori Ryohei、Shirai Toshiaki、Tsukiji Nagaharu、Oishi Saori、Sasaki Tomoyuki、Takano Katsuhiro、Suzuki-Inoue Katsue
- Journal Title
  
  Platelets
  
  Volume: 34 Issue: 1 Pages: 1-11
- DOI
  10.1080/09537104.2023.2281941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08500, KAKENHI-PROJECT-23K07831
[Journal Article] High plasma soluble CLEC-2 level predicts oxygen therapy requirement in patients with COVID-192023
- Author(s)
  Oishi Saori、Ueda Makyo、Yamazaki Hirokazu、Tsukiji Nagaharu、Shirai Toshiaki、Naito Yuna、Endo Masumi、Yokomori Ryohei、Sasaki Tomoyuki、Suzuki-Inoue Katsue
- Journal Title
  
  Platelets
  
  Volume: 34 Issue: 1 Pages: 1-6
- DOI
  10.1080/09537104.2023.2244594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08500, KAKENHI-PROJECT-23K07831
[Journal Article] Platelets and COVID-192023
- Author(s)
  SUZUKI-INOUE Katsue、SHIRAI Toshiaki、SASAKI Tomoyuki
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 34 Issue: 1 Pages: 53-57
- DOI
  10.2491/jjsth.34.53
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20K08729
[Journal Article] Detection of SARS-CoV-2 RNA Using RT-qPCR in Saliva Samples and Nasopharyngeal, Lingual, and Buccal Mucosal Swabs2022
- Author(s)
  Sasaki Tomoyuki、Inoue Osamu、Ogihara Shinji、Kubokawa Kayo、Oishi Saori、Shirai Toshiaki、Iwabuchi Keisuke、Suzuki-Inoue Katsue
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 75 Issue: 1 Pages: 102-104
- DOI
  10.7883/yoken.JJID.2021.091
- NAID
  130008143955
- ISSN
  1344-6304, 1884-2836
- Year and Date
  2022-01-31
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08729
[Journal Article] Apparent Life-Threatening Event in an Infant with SARS-CoV-2 Infection2021
- Author(s)
  Sano Fumikazu、Yagasaki Hideaki、Kojika Satoru、Toda Takako、Kono Yosuke、Suzuki-Inoue Katsue、Sasaki Tomoyuki、Ogihara Shinji、Matsuno Towa、Inoue Osamu、Moriguchi Takeshi、Harii Norikazu、Goto Junko、Shimizu Tatsuya、Inukai Takeshi
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 74 Issue: 3 Pages: 236-239
- DOI
  10.7883/yoken.JJID.2020.572
- NAID
  130008042007
- ISSN
  1344-6304, 1884-2836
- Year and Date
  2021-05-31
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08729
[Journal Article] Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ2021
- Author(s)
  S. Oishi, N. Tsukiji, S. Otake, N. Oishi, T. Sasaki, T. Shirai, Y. Yoshikawa, K. Takano, H. Shinmori, T. Inukai, T. Kondo, K. Suzuki-Inoue
- Journal Title
  
  blood advances
  
  Volume: 5 Issue: 7 Pages: 2017-2026
- DOI
  10.1182/bloodadvances.2020001698
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K04724, KAKENHI-PROJECT-19K16554, KAKENHI-PROJECT-19K08834, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-20K08729, KAKENHI-PROJECT-21K04674, KAKENHI-PROJECT-21K06883
[Journal Article] CLEC-2 stimulates IGF-1 secretion from podoplanin-positive stromal cells and positively regulates erythropoiesis in mice2021
- Author(s)
  Shimon Otake, Tomoyuki Sasaki, Toshiaki Shirai, Nagaharu Tsukiji, Shogo Tamura, Katsuhiro Takano, Yukio Ozaki, Katsue Suzuki-Inoue
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: - Issue: 6 Pages: 1572-1584
- DOI
  10.1111/jth.15317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05073, KAKENHI-PROJECT-18K16080, KAKENHI-PROJECT-19K08834, KAKENHI-PROJECT-20K08729
[Journal Article] A first case of meningitis/encephalitis associated with SARS-Coronavirus-22020
- Author(s)
  Moriguchi T、Harii N、Goto J、Harada D、Sugawara H、Takamino J、Ueno M、Sakata H、Kondo K、Myose N、Nakao A、Takeda M、Haro H、Inoue O、Suzuki-Inoue K、Kubokawa K、Ogihara S、Sasaki T、Kinouchi H、Kojin H、Ito M、Onishi H、Shimizu T、Sasaki Y、Enomoto N、Ishihara H、Furuya S、Yamamoto T、Shimada S
- Journal Title
  
  International Journal of Infectious Diseases
  
  Volume: 94 Pages: 55-58
- DOI
  10.1016/j.ijid.2020.03.062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08729
[Journal Article] Role of Platelet C-Type Lectin-Like Receptor 2 in Promoting Lung Metastasis in Osteosarcoma2020
- Author(s)
  Jiro Ichikawa, Takashi Ando, Tomonori Kawasaki, Tomoyuki Sasaki, Toshiaki Shirai, Nagaharu Tsukiji, Yujiro Kimura, Kaoru Aoki, Keiko Hayakawa, Katsue Suzuki-Inoue, Masao Saitoh, Hirotaka Haro
- Journal Title
  
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  
  Volume: in press Issue: 9 Pages: 1738-1750
- DOI
  10.1002/jbmr.4045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08654, KAKENHI-PROJECT-19K08834, KAKENHI-PROJECT-20K08729, KAKENHI-PROJECT-18K06912, KAKENHI-PROJECT-18K09060, KAKENHI-PROJECT-16H06276
[Journal Article] Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells2019
- Author(s)
  Y. Nakamura, T. Sasaki, C. Mochizuki, K. Ishimaru, S. Koizumi, H. Shinmori, K. Suzuki-Inoue, A. Nakao
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 15958-15958
- DOI
  10.1038/s41598-019-52449-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K04724, KAKENHI-PUBLICLY-18H05121, KAKENHI-PROJECT-17K16185, KAKENHI-PROJECT-16H04669, KAKENHI-PUBLICLY-19H04746
[Journal Article] Soluble CLEC-2 is generated independently of ADAM10 and is increased in plasma in acute coronary syndrome: comparison with soluble GPVI2019
- Author(s)
  Inoue Osamu、Osada Makoto、Nakamura Junya、Kazama Fuminori、Shirai Toshiaki、Tsukiji Nagaharu、Sasaki Tomoyuki、Yokomichi Hiroshi、Dohi Tomotaka、Kaneko Makoto、Kurano Makoto、Oosawa Mitsuru、Tamura Shogo、Satoh Kaneo、Takano Katsuhiro、Miyauchi Katsumi、Daida Hiroyuki、Yatomi Yutaka、Ozaki Yukio、Suzuki-Inoue Katsue
- Journal Title
  
  International Journal of Hematology
  
  Volume: 110 Issue: 3 Pages: 285-294
- DOI
  10.1007/s12185-019-02680-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08834, KAKENHI-PROJECT-18K17376, KAKENHI-PROJECT-17H05073, KAKENHI-PROJECT-18K19910, KAKENHI-PROJECT-17K16185
[Journal Article] Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction2018
- Author(s)
  Tsukiji Nagaharu、Inoue Osamu、Morimoto Mitsuru、Tatsumi Norifumi、Nagatomo Hiroaki、Ueta Koji、Shirai Toshiaki、Sasaki Tomoyuki、Otake Shimon、Tamura Shogo、Tachibana Toshiaki、Okabe Masataka、Hirashima Masanori、Ozaki Yukio、Suzuki-Inoue Katsue
- Journal Title
  
  Blood
  
  Volume: 132 Issue: 11 Pages: 1167-1179
- DOI
  10.1182/blood-2017-12-823369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19910, KAKENHI-PROJECT-17K15359, KAKENHI-PROJECT-17K16185, KAKENHI-PROJECT-17H05073, KAKENHI-PROJECT-16K19572
[Journal Article] Cobalt hematoporphyrin inhibits CLEC-2?podoplanin interaction, tumor metastasis, and arterial/venous thrombosis in mice2018
- Author(s)
  Tsukiji Nagaharu、Osada Makoto、Sasaki Tomoyuki、Shirai Toshiaki、Satoh Kaneo、Inoue Osamu、Umetani Norihiko、Mochizuki Chihiro、Saito Tamio、Kojima Soichi、Shinmori Hideyuki、Ozaki Yukio、Suzuki-Inoue Katsue
- Journal Title
  
  Blood Advances
  
  Volume: 2 Issue: 17 Pages: 2214-2225
- DOI
  10.1182/bloodadvances.2018016261
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K04724, KAKENHI-PROJECT-17K16185, KAKENHI-PROJECT-16K19572
[Journal Article] Functional characterization of recombinant snake venom rhodocytin: rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis2018
- Author(s)
  Sasaki T.、Shirai T.、Tsukiji N.、Otake S.、Tamura S.、Ichikawa J.、Osada M.、Satoh K.、Ozaki Y.、Suzuki-Inoue K.
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 16 Issue: 5 Pages: 960-972
- DOI
  10.1111/jth.13987
- NAID
  130008080766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19910, KAKENHI-PROJECT-17K16185, KAKENHI-PROJECT-17H05073, KAKENHI-PROJECT-16H06276
[Journal Article] CLEC-2 promotes hematogenous tumor metastasis and prothrombotic state in tumor-bearing mice.2016
- Author(s)
  Shirai, Toshiaki Inoue, Osamu Tamura, Shogo Tsukiji, Nagaharu Sasaki, Tomoyuki Endo, Hiroshi Satoh, Kaneo Osada, Makoto Sato-Uchida, Hitomi Fujii, Hideki Ozaki, Yukio Suzuki-Inoue, Katsue
- Journal Title
  
  Journal of thrombosis and haemostasis
  
  Volume: 38 Issue: 3 Pages: 42-49
- DOI
  10.1111/jth.13604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460671, KAKENHI-PROJECT-26461399, KAKENHI-PROJECT-15K19549, KAKENHI-PROJECT-26860723, KAKENHI-PROJECT-15K16234
[Journal Article] Podoplanin-positive periarteriolar stromal cells promote megakaryocyte growth and proplatelet formation in mice by CLEC-22016
- Author(s)
  TAMURA Shogo, SUZUKI-INOUE Katsue, TSUKIJI Nagaharu, SHIRAI Toshiaki, SASAKI Tomoyuki, OSADA Makoto, SATOH Kaneo, OZAKI Yukio
- Journal Title
  
  Blood
  
  Volume: 127 Issue: 13 Pages: 1701-1710
- DOI
  10.1182/blood-2015-08-663708
- NAID
  130007432250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460671, KAKENHI-PROJECT-26461399, KAKENHI-PROJECT-15K19549, KAKENHI-PROJECT-26860723, KAKENHI-PROJECT-13J04623
[Patent] CLEC-2拮抗剤，血小板凝集抑制剤，抗血栓薬，及び抗転移薬，並びにポルフィリン骨格を有する化合物，及びその製造方法2017
- Inventor(s)
  井上克枝，佐々木知幸，白井俊光，長田誠，新森英之
- Industrial Property Rights Holder
  国立大学法人山梨大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017-01-04
- Overseas
- Data Source
  KAKENHI-PROJECT-15K19549
[Patent] 機能抑制型の遺伝子組換えロドサイチン変異体2016
- Inventor(s)
  佐々木知幸，白井俊光，井上克枝
- Industrial Property Rights Holder
  国立大学法人山梨大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-094203
- Filing Date
  2016-05-09
- Data Source
  KAKENHI-PROJECT-15K19549
[Patent] CLEC-2拮抗剤，血小板凝集抑制剤，抗血栓薬，及び抗転移薬，並びにポルフィリン骨格を有する化合物，及びその製造方法2016
- Inventor(s)
  井上克枝，佐々木知幸，白井俊光，長田誠，新森英之
- Industrial Property Rights Holder
  国立大学法人山梨大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-000267
- Filing Date
  2016-01-04
- Data Source
  KAKENHI-PROJECT-15K19549
[Presentation] 硫酸化多糖カラギナンによるヒト血小板活性化機構2023
- Author(s)
  横森良平、白井俊光、佐々木知幸、築地長治、大石沙織、髙野勝弘、井上克枝
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07831
[Presentation] The molecular basis of carrageenan-induced thrombosis involves platelet activation via C-type lectin like receptor 2 (CLEC-2)2023
- Author(s)
  Ryohei Yokomori, Toshiaki Shirai, Saori Oishi, Tomoyuki Sasaki, Nagaharu Tsukiji, Katsuhiro Takano, Katsue Suzuki-Inoue
- Organizer
  ISTH 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07831
[Presentation] 硫酸化多糖カラギナンは、血小板受容体C-type lectin-like receptor2依存的に血小板凝集を惹起する2023
- Author(s)
  横森良平、大石沙織、佐々木知幸、髙野勝弘、井上克枝
- Organizer
  第70回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07831
[Presentation] 鉄によるCLEC-2依存性血小板活性化機構とその生理的意義2023
- Author(s)
  築地長治、横森良平、田草川一穂、大石沙織、白井俊光、佐々木知幸、髙野勝弘、井上克枝
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07831
[Presentation] 新型コロナウイルスによる血小板血栓形成メカニズムの解明2023
- Author(s)
  佐々木知幸、白井俊光、築地長治、大石沙織、横森良平、髙野勝弘、森石恆司、井上克枝
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07831
[Presentation] 可溶型CLEC-2はCOVID-19患者の酸素療法の必要性を予測する2023
- Author(s)
  大石沙織、上田眞叶、山﨑浩和、築地長治、白井俊光、内藤悠菜、遠藤真澄、佐々木知幸、井上克枝
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07831
[Presentation] 癌関連線維芽細胞はCLEC-2/PDPNを介して癌関連血栓症を増悪させる2022
- Author(s)
  白井俊光, 佐々木知幸, 築地長治, 大石沙織, 横森良平, 高野勝弘, 井上克枝
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 癌関連線維芽細胞はCLEC-2/PDPNを介して癌関連血栓症を増悪させる2022
- Author(s)
  白井俊光、佐々木知幸、築地長治、大石沙織、横森良平、高野勝弘、井上克枝
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08499
[Presentation] 硫酸化多糖カラギーナンはCLEC-2依存症に血小板を活性化する2022
- Author(s)
  横森良平, 白井俊光, 佐々木知幸, 築地長治, 大石沙織, 高野勝弘, 井上克枝
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 硫酸化多糖カラギーナンはCLEC-2依存性に血小板を活性化する2022
- Author(s)
  横森良平、白井俊光、佐々木知幸、築地長治、大石沙織、高野勝弘、井上克枝
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08499
[Presentation] Cancer-associated fibroblasts promote venous thrombosis through C-type lectin-like receptor 2/podoplanin in 3LL lung cancer mouse model2022
- Author(s)
  T. Shirai, T. Sasaki, N. Tsukiji, S. Ohishi, R. Yokomori, K. Takano, K. Suzuki-Inoue
- Organizer
  International Society on Thrombosis and Haemostasis 2022 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08499
[Presentation] Cancer-associated fibroblasts promote venous thrombosis through C-type lectin-like receptor 2/podoplanin in 3LL lung cancer mouse model2022
- Author(s)
  Shirai T, Sasaki T, Tsukiji N, Ohishi S, Yokomori R, Takano K, Suzuki-Inoue K.
- Organizer
  ISTH 2022 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] CLEC-2はPDPN発現間質細胞からのIGF-1分泌を促進し、赤血球造血を正に制御する2021
- Author(s)
  大竹志門, 佐々木知幸, 白井俊光, 築地長治, 高野勝弘, 田村彰吾, 尾崎由基男, 井上克枝
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] Functional characterization of recombinant snake verom rhodocytin: rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis.2021
- Author(s)
  Tomoyuki Sasaki
- Organizer
  第43回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 横紋筋融解症に併発する腎障害における血小板CLEC-2及びGPVIの役割2021
- Author(s)
  大石沙織，築地長治、大竹志門、大石直輝、佐々木知幸、白井俊光、吉河佑莉、髙野勝弘、新森英之、犬飼岳史、近藤哲夫、井上克枝
- Organizer
  第43回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 巨核球・血小板上C-type lectin-like receptor 2 (CLEC-2)の赤血球造血における役割2020
- Author(s)
  大竹志門, 白井俊光, 築地長治, 佐々木知幸, 田村彰吾, 高野勝弘, 尾崎由基男, 井上克枝
- Organizer
  第42回日本血栓止血学会学術集会(2020.06.18)
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] Heme Activates Platelets and Exacerbates Rhabdomyolysis-Induced Acute Kidney Injury via CLEC-2 and GPVI/FcRγ2020
- Author(s)
  S. Oishi, N. Tsukiji, S. Otake, N. Oishi, T. Sasaki, T. Shirai, Y. Yoshikawa, K. Takano, T. Kondo, K. Suzuki-Inoue
- Organizer
  ISTH 2020 Congress(2020.07.12)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 横紋筋融解症に併発する腎障害における血小板CLEC-2およびGPVIの役割2020
- Author(s)
  大石沙織, 築地長治, 大竹志門, 大石直輝, 佐々木知幸, 白井俊光, 吉河佑莉, 高野勝弘, 近藤哲夫, 井上克枝
- Organizer
  第42回日本血栓止血学会学術集会(2020.06.18)
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 血小板受容体CLEC-2による関節リウマチの病態形成への関与2020
- Author(s)
  佐々木知幸, 白井俊光, 築地長治, 小山賢介, 田村彰吾, 大竹志門, 高野勝弘, 長田誠, 佐藤金夫, 波呂浩孝, 尾崎由基男, 井上克枝
- Organizer
  第42回日本血栓止血学会学術集会(2020.06.18)
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 血小板・巨核球上のC型レクチン様受容体（CLEC-2）が赤血球造血に及ぼす役割2019
- Author(s)
  大竹志門，白井俊光，築地長治，佐々木知幸，田村彰吾，尾崎由基男，井上克枝
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] ヘム惹起血小板凝集及び横紋筋融解誘導性急性腎障害における血小板CLEC-2の関与2019
- Author(s)
  築地長治，大竹志門，佐々木知幸，吉河佑莉，高野勝弘，井上克枝
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] Heme Induces Platelet Aggregation via Two ITAM Receptors: Implications in Rhabdomyolysis-Induced Acute Kidney Injury.2019
- Author(s)
  Tsukiji N, Oishi S, Otake S, Sasaki T, Takano K, Suzuki-Inoue K
- Organizer
  ISTH 2019 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] Platelet C-type Lectin-Like Receptor 2 (CLEC-2) is Required for Optimal Regulation of Erythropoiesis.2019
- Author(s)
  Otake S, Shirai S, Tsukiji N, Sasaki T, Satoh K, Tamura S, Takano K, Ozaki Y, Suzuki-Inoue K
- Organizer
  ISTH 2019 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] Essential role of platelet-expressed C-type lectin-like receptor 2 (CLEC-2) in erythropoiesis．2019
- Author(s)
  Shimon Otake, Toshiaki Shirai, Nagaharu Tsukiji, Tomoyuki Sasaki, Kaneo Satoh, Shogo Tamura, Yukio Ozaki, Katsue Suzuki-Inoue
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] 血小板・巨核球上の C 型レクチン様受容体(CLEC-2)が，赤血球造血に及ぼす役割2019
- Author(s)
  大竹志門，白井俊光，築地長治，佐々木知幸，田村彰吾，尾崎由基男，井上克枝
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19910
[Presentation] GPVI依存性血小板凝集を惹起する蛇毒コンバルキシンの遺伝子組換え体の作製と機能解析2018
- Author(s)
  佐々木知幸, 白井俊光, 築地長治, 大竹志門, 田村彰吾, 長田誠, 佐藤金夫, 尾崎由基男, 井上克枝
- Organizer
  第91回日本生化学会大会，京都(2018.9.24-26)
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] 血小板・巨核球上のC型レクチン様受容体（CLEC-2）が赤血球造血に及ぼす役割2018
- Author(s)
  大竹志門, 白井俊光, 築地長治, 佐々木知幸, 佐藤金夫, 田村彰吾, 尾崎由基男, 井上克枝
- Organizer
  第80回日本血液学会学術集会，大阪(2018.10.12-14)
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] Platelets as a novel key player in organogenesis: Clec-2/podoplanin interaction regulates fetal lung development2018
- Author(s)
  築地長治，井上修，辰巳徳史，岡部正隆，森本充，植田康司，平島正則，佐々木知幸，白井俊光，田村彰吾，大竹志門，佐藤金夫，尾崎由基男，井上克枝
- Organizer
  第40回日本血栓止血学会学術集会，札幌(2018.6.28-30)
- Invited
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] 血小板受容体GPVIアゴニスト蛇毒コンバルキシンの遺伝組換体の作製とその機能解析2018
- Author(s)
  佐々木知幸，白井俊光，築地長治，大竹志門，田村彰吾，長田誠，佐藤金夫，尾崎由基男，井上克枝
- Organizer
  第40回日本血栓止血学会学術集会，札幌(2018.6.28-30)
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] 脳梗塞の増悪因子であるアクロレインの抗血小板作用2018
- Author(s)
  梅谷徳彦，白井俊光，築地長治，佐々木知幸，田村彰吾，佐藤金夫，大竹志門，高野勝弘，横道洋司，尾崎由基男，井上克枝
- Organizer
  第40回日本血栓止血学会学術集会，札幌(2018.6.28-30)
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] 血小板・巨核球上のC型レクチン様受容体（CLEC-2）が、赤芽球の分化、成熟に及ぼす役割2018
- Author(s)
  大竹志門，白井俊光，築地長治，佐々木知幸，田村彰吾，佐藤金夫，尾崎由基男，井上克枝
- Organizer
  第40回日本血栓止血学会学術集会，札幌(2018.6.28-30)
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] 血小板受容体GPVIアゴニスト蛇毒コンバルキシンの遺伝子組換体の作製とその機能解析2018
- Author(s)
  佐々木知幸，白井俊光，築地長治，大竹志門，田村彰吾，長田誠，佐藤金夫，尾崎由基男，井上克枝
- Organizer
  第40回日本血栓止血学会学術集会，札幌(2018.6.28-30)
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] 関節リウマチにおける血小板CLEC-2の役割2017
- Author(s)
  佐々木知幸，白井俊光，築地長治，小山賢介，田村彰吾，大竹志門，長田誠，佐藤金夫，波呂浩孝，尾崎由基男，井上克枝
- Organizer
  第39回日本血栓止血学会学術集会，名古屋(2017.6.8-10)
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] 血小板活性化により生成される可溶性CLEC-2の測定法に関する有用性2017
- Author(s)
  長田誠，大澤満，佐々木知幸，井上修，井上克枝，藤田清貴
- Organizer
  日本臨床化学会　第57回年次学術集会，札幌(2017.10.6-8)
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] 血小板によるCLEC-2-Podoplaninシグナルを介した新たな肺胞形成メカニズム2017
- Author(s)
  築地長治，井上修，辰巳徳史，岡部正隆，森本充，植田康司，平島正則，佐々木知幸，白井俊光，田村彰吾，大竹志門，佐藤金夫，尾崎由基男，井上克枝
- Organizer
  第39回日本血栓止血学会学術集会，名古屋(2017.6.8-10)
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] 関節リウマチにおける血小板活性化受容体CLEC-2の役割の解明2017
- Author(s)
  佐々木知幸，白井俊光，築地長治，小山賢介，田村彰吾，大竹志門，長田誠，佐藤金夫，波呂浩孝，尾崎由基男，井上克枝
- Organizer
  2017年度　生命科学系学会合同年次大会（ConBio2017），神戸(2017.12.6-9)
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] An inhibitory mutant of snake venom rhodocytin blocks CLEC-2/Podoplanin interaction dependent platelet aggregation and experimental lung metastasis.2017
- Author(s)
  Sasaki T, Shirai T, Tsukiji N, Otake S, Tamura S, Osada M, Satoh K, Ozaki Y, Suzuki-Inoue K
- Organizer
  ISTH 2017 Congress, Berlin, Germany. (July 8-13 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16185
[Presentation] 遺伝子組換えロドサイチンを用いたCLEC-2依存性血小板凝集の制御解析2016
- Author(s)
  佐々木知幸，白井俊光，築地長治，田村彰吾，長田誠，佐藤金夫，尾崎由基男，井上克枝
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良春日野国際フォーラム（奈良・奈良）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K19549
[Presentation] 血小板CLEC-2は肺中皮細胞分化を介して呼吸機能獲得に寄与する2016
- Author(s)
  築地長治，井上修，田村彰吾，白井俊光，佐々木知幸，佐藤金夫，尾崎由基男，井上克枝
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良春日野国際フォーラム（奈良・奈良）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K19549
[Presentation] ポドプラニン結合阻害能を持つCLEC-2結合低分子化合物リガンド2016
- Author(s)
  井上克枝，新森英之，長田誠，白井俊光，望月ちひろ，小嶋聡一，斎藤臣雄，佐々木知幸，井上修，尾崎由基男
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良春日野国際フォーラム（奈良・奈良）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K19549
[Presentation] 変異型ロドサイチンによるポドプラニン依存性の癌細胞血行性転移の抑制2016
- Author(s)
  佐々木知幸, 白井俊光, 築地長治, 田村彰吾, 長田誠, 佐藤金夫, 尾崎由基男, 井上克枝
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城・仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K19549
[Presentation] 血小板は肺発生に必須である：血小板CLEC-2の機能解析2015
- Author(s)
  築地長治，井上修，田村彰吾，白井俊光，佐々木知幸，佐藤金夫，井上克枝，尾崎
- Organizer
  第37回日本血栓止血学会学術集会
- Place of Presentation
  甲府市総合市民会館（山梨・甲府）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K19549
[Presentation] Construction of expression system for biologically functional recombinant rhodocytin.2015
- Author(s)
  Tomoyuki Sasaki, Shogo Tamura, Toshiaki Shirai, Nagaharu Tsukiji, Kaneo Satoh, Katsue Suzuki-Inoue, Yukio Ozaki
- Organizer
  ISTH 2015 第25回国際血栓止血学会議
- Place of Presentation
  トロント（カナダ）
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19549
[Presentation] A novel function of CLEC-2 in megakaryopoiesis: CLEC-2/PDPN microenvironment facilitates expansion and maturation of magakaryocytes.2015
- Author(s)
  Shogo Tamura, Katsue Suzuki-Inoue, Nagaharu Tsukiji, Toshiaki Shirai, Tomoyuki Sasaki, Makoto Osada, Kaneo Satoh, Yukio Ozaki
- Organizer
  ISTH 2015 第25回国際血栓止血学会議
- Place of Presentation
  トロント（カナダ）
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19549
[Presentation] 血小板活性化受容体CLEC-2結合蛇毒ロドサイチンの機能を保持したリコンビナント体発現系の構築2015
- Author(s)
  佐々木知幸，田村彰吾，白井俊光，築地長治，佐藤金夫，井上克枝，尾崎由基男
- Organizer
  第37回日本血栓止血学会学術集会
- Place of Presentation
  甲府市総合市民会館（山梨・甲府）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K19549
[Presentation] CLEC-2依存性血小板凝集を惹起する蛇毒ロドサイチンの遺伝子組換え体の作製と機能解析2015
- Author(s)
  佐々木知幸, 田村彰吾, 白井俊光, 築地長治, 佐藤金夫, 井上克枝, 尾崎由基男
- Organizer
  BMB2015(第38回日本分子生物学会年会／第88回日本生化学会大会合同大会)
- Place of Presentation
  神戸ポートアイランド（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K19549
[Presentation] CLEC-2/PDPN axisによる骨髄内微小環境の可能性：CLEC-2は巨核球造血を促進させる2015
- Author(s)
  田村彰吾，井上克枝，白井俊光，築地長治，佐々木知幸，佐藤金夫，尾崎由基男
- Organizer
  第37回日本血栓止血学会学術集会
- Place of Presentation
  甲府市総合市民会館（山梨・甲府）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K19549
[Presentation] Unexpected role of platelets in lung development depending on a platelet activation receptor, CLEC-2.2015
- Author(s)
  Nagaharu Tsukiji, Osamu Inoue, Shogo Tamura, Toshiaki Shirai, Tomoyuki Sasaki, Kaneo Satoh, Katsue Suzuki-Inoue, Yukio Ozaki
- Organizer
  ISTH 2015 第25回国際血栓止血学会議
- Place of Presentation
  トロント（カナダ）
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19549

1. Suzuki-INoue Katsue (10324211)

# of Collaborated Projects: 5 results

# of Collaborated Products: 34 results
2. 築地長治 (20710362)

# of Collaborated Projects: 5 results

# of Collaborated Products: 31 results
3. 白井俊光 (50710381)

# of Collaborated Projects: 5 results

# of Collaborated Products: 28 results
4. 大石沙織 (50894094)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
5. Tamura Shogo (60722626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. 小嶋哲人 (40161913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 大竹志門 (50813060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. 平島正則 (40383757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHINMORI Hedeyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. OZAKI Yukio

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
11. KAWASAKI Tomonori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 佐藤金夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 佐藤晋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 佐藤篤靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SASAKI Tomoyuki 佐々木 知幸

Research Projects

Research Products

Co-Researchers

SARS-CoV-2による血小板血栓の形成メカニズムの解析Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

iPS細胞由来巨核球が産生する血小板を活用したヒトCLEC-2の機能解析

Principal Investigator

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Research Institution

Development of antibody drugs targeting platelet activating receptor CLEC-2 and elucidation of the pharmacological actionsPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

A role of platelets in lymphoid tissue development: platelets as a cargo of bioactive substances

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Development zeno-free/self-feeder culture system for an efficient iPSC derived platelet production

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Elucidation of the relationship between the platelet receptor CLEC-2 and the pathophysiology of sepsis and its application as a new therapeutic targetPrincipal Investigator

Principal Investigator

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Research Institution

Development of molecular-targeted therapeutic agent targeting novel platelet activation receptor CLEC-2Principal Investigator

Principal Investigator

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Research Institution

[Journal Article] Cancer-associated fibroblasts promote venous thrombosis through podoplanin/CLEC-2 interaction in podoplanin-negative lung cancer mouse model2023

Author(s)

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[Journal Article] C-type lectin-like receptor-2 (CLEC-2) is a key regulator of kappa-carrageenan-induced tail thrombosis model in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High plasma soluble CLEC-2 level predicts oxygen therapy requirement in patients with COVID-192023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Platelets and COVID-192023

Author(s)

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[Journal Article] Detection of SARS-CoV-2 RNA Using RT-qPCR in Saliva Samples and Nasopharyngeal, Lingual, and Buccal Mucosal Swabs2022

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[Journal Article] Apparent Life-Threatening Event in an Infant with SARS-CoV-2 Infection2021

Author(s)

Journal Title

SASAKI Tomoyuki 佐々木知幸