Adachi Yuu 安達悠

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Adachi Yu 安達悠

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Researcher Number	40749016
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所ワクチン開発研究センター, 主任研究員
Affiliation (based on the past Project Information) *help	2021 – 2024: 国立感染症研究所, 治療薬・ワクチン開発研究センター, 主任研究官 2017 – 2020: 国立感染症研究所, 免疫部, 主任研究官 2016: 国立感染症研究所, 免疫部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Immunology Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator ワクチン / 交差防御抗体 / インフルエンザ / インフルエンザウイルス / 免疫学 / インフルエンザワクチン / B細胞 / 交差中和抗体 / SARS-CoV-2 / 抗体 … More / 免疫 / ヒト交差防御抗体 / ユニバーサルワクチン / Ｂ細胞 … More Except Principal Investigator レポーターマウス / niche / 生存 / 骨髄 / 長期生存 / イメージング / 抗体 / 寿命 / プラズマ細胞 Less

変異株対応型COVID-19ワクチン開発に資する交差中和抗体の制御機序の解明Principal Investigator
- Principal Investigator
  
  安達悠
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  National Institute of Infectious Diseases
Characterizing human cross-protective antibodies for a universal influenza vaccinePrincipal Investigator
- Principal Investigator
  
  Adachi Yu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  National Institute of Infectious Diseases
Cross-protective antibody response in the lungs upon influenza virus infectionPrincipal Investigator
- Principal Investigator
  
  ADACHI Yu
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  National Institute of Infectious Diseases
Analysis of cellular dynamics of long-lived plasma cells identified by using a novel reporter mouse system
- Principal Investigator
  
  Ise Wataru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Osaka University
Cross-protective antibody responses against influenza virus infectionPrincipal Investigator
- Principal Investigator
  
  Adachi Yu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  National Institute of Infectious Diseases

All 2023 2022 2021 2020 2019 2017 2016

All Journal Article Presentation Patent

[Journal Article] Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope2023
- Author(s)
  Tonouchi K, Adachi Y, Suzuki T, Kuroda D, Nishiyama A, Yumoto K, Takeyama H, Suzuki T, Hashiguchi T, Takahashi Y.
- Journal Title
  
  PLoS Pathog .
  
  Volume: 19(8) Issue: 8 Pages: e1011554-e1011554
- DOI
  10.1371/journal.ppat.1011554
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-21K08192, KAKENHI-PROJECT-22KJ2889, KAKENHI-PROJECT-23K27422
[Journal Article] Saliva as a useful tool for evaluating upper mucosal antibody response to influenza2022
- Author(s)
  Tsunetsugu-Yokota Yasuko、Ito Sayaka、Adachi Yu、Onodera Taishi、Kageyama Tsutomu、Takahashi Yoshimasa
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 2 Pages: e0263419-e0263419
- DOI
  10.1371/journal.pone.0263419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08192
[Journal Article] Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells2021
- Author(s)
  Miyauchi Kosuke、Adachi Yu、Tonouchi Keisuke、Yajima Taiki、Harada Yasuyo、Fukuyama Hidehiro、Deno Senka、Iwakura Yoichiro、Yoshimura Akihiko、Hasegawa Hideki、Yugi Katsuyuki、Fujii Shin-ichiro、Ohara Osamu、Takahashi Yoshimasa、Kubo Masato
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41467-021-24090-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-21K08192
[Journal Article] Memory B Cells in Local and Systemic Sites2020
- Author(s)
  Moriyama Saya、Adachi Yu、Tonouchi Keisuke、Takahashi Yoshimasa
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 1254 Pages: 55-62
- DOI
  10.1007/978-981-15-3532-1_5
- ISBN
  9789811535314, 9789811535321
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-19K17656
[Journal Article] Stereotyped B-cell response that counteracts antigenic variation of influenza viruses2020
- Author(s)
  Tonouchi Keisuke、Adachi Yu、Moriyama Saya、Sano Kaori、Tabata Koshiro、Ide Keigo、Takeyama Haruko、Suzuki Tadaki、Takahashi Yoshimasa
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 9 Pages: 613-621
- DOI
  10.1093/intimm/dxaa038
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-20H03500, KAKENHI-PROJECT-20J22269, KAKENHI-PROJECT-19K17656
[Journal Article] Bim establishes the B-cell repertoire from early to late in the immune response2020
- Author(s)
  Sugimoto-Ishige Akiko、Harada Michishige、Tanaka Miho、Terooatea Tommy、Adachi Yu、Takahashi Yoshimasa、Tanaka Takashi、Burrows Peter D、Hikida Masaki、Takemori Toshitada
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 2 Pages: 79-90
- DOI
  10.1093/intimm/dxaa060
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07618, KAKENHI-PROJECT-19K17656
[Journal Article] Hide and seek: interplay between influenza viruses and B cells2020
- Author(s)
  Kuraoka Masayuki、Adachi Yu、Takahashi Yoshimasa
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 9 Pages: 605-611
- DOI
  10.1093/intimm/dxaa028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-19K17656
[Journal Article] Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism2019
- Author(s)
  Watanabe A, McCarthy KR, Kuraoka M, Schmidt AG, Adachi Y, Onodera T, Tonouchi K, Caradonna TM, Bajic G, Song S, McGee CE, Sempowski GD, Feng F, Urick P, Kepler TB, Takahashi Y, Harrison SC, Kelsoe G.Influenza
- Journal Title
  
  Cell
  
  Volume: 177(5) Issue: 5 Pages: 1124-1135
- DOI
  10.1016/j.cell.2019.03.048
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08895, KAKENHI-PROJECT-19K17656
[Journal Article] Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope2019
- Author(s)
  Bajic G, Maron MJ, Adachi Y, Onodera T, McCarthy KR, McGee CE, Sempowski GD, Takahashi Y, Kelsoe G, Kuraoka M, Schmidt AG.Influenza
- Journal Title
  
  Cell Host and Microbe
  
  Volume: 25(6) Issue: 6 Pages: 827-835
- DOI
  10.1016/j.chom.2019.04.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08895, KAKENHI-PROJECT-19K17656
[Journal Article] 【インフルエンザウイルスと防御】隠れたインフルエンザヘマグルチニンエピトープに対する交差防御抗体2019
- Author(s)
  安達悠, 登内奎介, 高橋宜聖
- Journal Title
  
  ウイルス
  
  Volume: 69 Pages: 161-168
- Data Source
  KAKENHI-PROJECT-19K17656
[Journal Article] Requirement for memory B-cell activation in protection from heterologous influenza virus reinfection2019
- Author(s)
  Leach Sarah、Shinnakasu Ryo、Adachi Yu、Momota Masatoshi、Makino-Okamura Chieko、Yamamoto Takuya、Ishii Ken J、Fukuyama Hidehiro、Takahashi Yoshimasa、Kurosaki Tomohiro
- Journal Title
  
  International Immunology
  
  Volume: 31 Issue: 12 Pages: 771-779
- DOI
  10.1093/intimm/dxz049
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21601, KAKENHI-PROJECT-19K17656, KAKENHI-PROJECT-19H01028, KAKENHI-PROJECT-17K08856, KAKENHI-PROJECT-18K19447
[Journal Article] Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies2019
- Author(s)
  Adachi Yu、Tonouchi Keisuke、Nithichanon Arnone、Kuraoka Masayuki、Watanabe Akiko、Shinnakasu Ryo、Asanuma Hideki、Ainai Akira、Ohmi Yusuke、Yamamoto Takuya、Ishii Ken J.、Hasegawa Hideki、Takeyama Haruko、Lertmemongkolchai Ganjana、Kurosaki Tomohiro、Ato Manabu、Kelsoe Garnett、Takahashi Yoshimasa
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41467-019-11821-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21601, KAKENHI-PROJECT-19K17656, KAKENHI-PROJECT-19H01028, KAKENHI-PROJECT-17K08856, KAKENHI-PROJECT-18K19447
[Journal Article] インフルエンザウイルスに対するヒト交差防御抗体による感染防御機構2017
- Author(s)
  小野寺大志、安達悠、高橋宜聖
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 68 Pages: 146-153
- Data Source
  KAKENHI-PROJECT-16K19167
[Journal Article] Adaptive B cell responses to influenza virus infection in the lung.2017
- Author(s)
  Takahashi, Y., Onodera, T., Adachi, Y., Ato, M
- Journal Title
  
  Viral Immunology
  
  Volume: 30 Issue: 6 Pages: 431-437
- DOI
  10.1089/vim.2017.0025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08895, KAKENHI-PROJECT-16K19167
[Patent] インフルエンザＨＡスプリットワクチンの製造方法2017
- Inventor(s)
  高橋宜聖、安達悠、阿戸学
- Industrial Property Rights Holder
  高橋宜聖、安達悠、阿戸学
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K19167
[Presentation] Regulation of antibody breadth to mutating viruses through distinct germinal center selection.2017
- Author(s)
  Takahashi, Y., Ato, M., Adachi, Y.
- Organizer
  Awaji International Forum on Infection and Immunity
- Invited
- Data Source
  KAKENHI-PROJECT-16K19167
[Presentation] Influenza hemagglutinin epitopes emerging at viral replication sites promote the clonal selection and plasma cell development of broadly protective B cells2017
- Author(s)
  Yu Adachi, Arnone Nithichannon, Masayuki Kuraoka, Garnett Kelsoe, Manabu Ato, Yoshimasa Takahashi.
- Organizer
  Keystone symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19167
[Presentation] Different accessibility of strain-specific versus cross-reactive BCRs to virus particles regulates site-specific germinal center selection.2016
- Author(s)
  Adachi, Y., Onodera, T., Ato, M., Takahashi, Y.
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄県宜野湾市　沖縄コンベンションセンター
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K19167

1. Ise Wataru (70323483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 黒崎知博 (50178125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 小野寺大志

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 高橋宜聖

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
5. 山本拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 疋田正喜

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 岩倉洋一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Adachi Yuu 安達 悠

Adachi Yu 安達 悠

Research Projects

Research Products

Co-Researchers

変異株対応型COVID-19ワクチン開発に資する交差中和抗体の制御機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterizing human cross-protective antibodies for a universal influenza vaccinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cross-protective antibody response in the lungs upon influenza virus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of cellular dynamics of long-lived plasma cells identified by using a novel reporter mouse system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cross-protective antibody responses against influenza virus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Saliva as a useful tool for evaluating upper mucosal antibody response to influenza2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Memory B Cells in Local and Systemic Sites2020

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Stereotyped B-cell response that counteracts antigenic variation of influenza viruses2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bim establishes the B-cell repertoire from early to late in the immune response2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hide and seek: interplay between influenza viruses and B cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope2019

Author(s)

Journal Title

DOI

Adachi Yuu 安達悠

Adachi Yu 安達悠